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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WBSCR22-LIMK1 (FusionGDB2 ID:98815)

Fusion Gene Summary for WBSCR22-LIMK1

check button Fusion gene summary
Fusion gene informationFusion gene name: WBSCR22-LIMK1
Fusion gene ID: 98815
HgeneTgene
Gene symbol

WBSCR22

LIMK1

Gene ID

114049

3984

Gene nameBUD23 rRNA methyltransferase and ribosome maturation factorLIM domain kinase 1
SynonymsHASJ4442|HUSSY-3|MERM1|PP3381|WBMT|WBSCR22LIMK|LIMK-1
Cytomap

7q11.23

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionprobable 18S rRNA (guanine-N(7))-methyltransferaseWilliams-Beuren candidate region putative methyltransferaseWilliams-Beuren syndrome chromosomal region 22 proteinWilliams-Beuren syndrome chromosome region 22bud site selection protein 23 homologmetasLIM domain kinase 1LIM motif-containing protein kinase
Modification date2020032720200313
UniProtAcc.

P53667

Ensembl transtripts involved in fusion geneENST00000423166, ENST00000265758, 
ENST00000423497, ENST00000464615, 
ENST00000336180, ENST00000418310, 
ENST00000538333, ENST00000491052, 
Fusion gene scores* DoF score4 X 4 X 2=324 X 5 X 4=80
# samples 45
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WBSCR22 [Title/Abstract] AND LIMK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWBSCR22(73112024)-LIMK1(73520205), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLIMK1

GO:0006468

protein phosphorylation

17512523|22328514

TgeneLIMK1

GO:0032233

positive regulation of actin filament bundle assembly

17512523

TgeneLIMK1

GO:0051444

negative regulation of ubiquitin-protein transferase activity

17512523


check buttonFusion gene breakpoints across WBSCR22 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LIMK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-CM-6675-01AWBSCR22chr7

73112024

+LIMK1chr7

73520205

+


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Fusion Gene ORF analysis for WBSCR22-LIMK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000423166ENST00000336180WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
3UTR-3CDSENST00000423166ENST00000418310WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
3UTR-3CDSENST00000423166ENST00000538333WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
3UTR-3UTRENST00000423166ENST00000491052WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
5CDS-3UTRENST00000265758ENST00000491052WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
5CDS-3UTRENST00000423497ENST00000491052WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
In-frameENST00000265758ENST00000336180WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
In-frameENST00000265758ENST00000418310WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
In-frameENST00000265758ENST00000538333WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
In-frameENST00000423497ENST00000336180WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
In-frameENST00000423497ENST00000418310WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
In-frameENST00000423497ENST00000538333WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
intron-3CDSENST00000464615ENST00000336180WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
intron-3CDSENST00000464615ENST00000418310WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
intron-3CDSENST00000464615ENST00000538333WBSCR22chr7

73112024

+LIMK1chr7

73520205

+
intron-3UTRENST00000464615ENST00000491052WBSCR22chr7

73112024

+LIMK1chr7

73520205

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265758WBSCR22chr773112024+ENST00000418310LIMK1chr773520205+3409849582184708
ENST00000265758WBSCR22chr773112024+ENST00000336180LIMK1chr773520205+3409849582184708
ENST00000265758WBSCR22chr773112024+ENST00000538333LIMK1chr773520205+2342849582184708
ENST00000423497WBSCR22chr773112024+ENST00000418310LIMK1chr773520205+340284202177725
ENST00000423497WBSCR22chr773112024+ENST00000336180LIMK1chr773520205+340284202177725
ENST00000423497WBSCR22chr773112024+ENST00000538333LIMK1chr773520205+233584202177725

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265758ENST00000418310WBSCR22chr773112024+LIMK1chr773520205+0.0044391360.9955609
ENST00000265758ENST00000336180WBSCR22chr773112024+LIMK1chr773520205+0.0044391360.9955609
ENST00000265758ENST00000538333WBSCR22chr773112024+LIMK1chr773520205+0.0083297860.99167025
ENST00000423497ENST00000418310WBSCR22chr773112024+LIMK1chr773520205+0.0059281510.9940718
ENST00000423497ENST00000336180WBSCR22chr773112024+LIMK1chr773520205+0.0059281510.9940718
ENST00000423497ENST00000538333WBSCR22chr773112024+LIMK1chr773520205+0.0109426210.98905736

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Fusion Genomic Features for WBSCR22-LIMK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WBSCR22chr773112024+LIMK1chr773520204+1.06E-060.9999989
WBSCR22chr773112024+LIMK1chr773520204+1.06E-060.9999989

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for WBSCR22-LIMK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:73112024/chr7:73520205)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LIMK1

P53667

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:16230460, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23633677}.; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269|PubMed:10196227}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLIMK1chr7:73112024chr7:73520205ENST00000336180416339_604202648.0DomainProtein kinase
TgeneLIMK1chr7:73112024chr7:73520205ENST00000538333315339_604168614.0DomainProtein kinase
TgeneLIMK1chr7:73112024chr7:73520205ENST00000336180416345_353202648.0Nucleotide bindingATP
TgeneLIMK1chr7:73112024chr7:73520205ENST00000538333315345_353168614.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLIMK1chr7:73112024chr7:73520205ENST00000336180416165_258202648.0DomainPDZ
TgeneLIMK1chr7:73112024chr7:73520205ENST0000033618041625_75202648.0DomainLIM zinc-binding 1
TgeneLIMK1chr7:73112024chr7:73520205ENST0000033618041684_137202648.0DomainLIM zinc-binding 2
TgeneLIMK1chr7:73112024chr7:73520205ENST00000538333315165_258168614.0DomainPDZ
TgeneLIMK1chr7:73112024chr7:73520205ENST0000053833331525_75168614.0DomainLIM zinc-binding 1
TgeneLIMK1chr7:73112024chr7:73520205ENST0000053833331584_137168614.0DomainLIM zinc-binding 2


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Fusion Gene Sequence for WBSCR22-LIMK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98815_98815_1_WBSCR22-LIMK1_WBSCR22_chr7_73112024_ENST00000265758_LIMK1_chr7_73520205_ENST00000336180_length(transcript)=3409nt_BP=849nt
GACATAAAAACCGGGTGCCGGCAGGCGCCAGTCGCAGGTGTGCTGCTGAGGCGTGAGAATGGCGTCCCGCGGCCGGCGTCCGGAGCATGG
CGGACCCCCAGAGCTGTTTTATGACGAGACAGAAGCCCGGAAATACGTTCGCAACTCACGGATGATTGATATCCAGACCAGGATGGCTGG
GCGAGCATTGGAGCTTCTTTATCTGCCAGAGAATAAGCCCTGTTACCTGCTGGATATTGGCTGTGGCACTGGGCTGAGTGGAAGTTATCT
GTCAGATGAAGGGCACTATTGGGTGGGCCTGGATATCAGCCCTGCCATGCTGGATGAGGCTGTGGACCGAGAGATAGAGGGAGACCTGCT
GCTGGGGGATATGGGCCAGGGCATCCCATTCAAGCCAGGCACATTTGATGGTTGCATCAGCATTTCTGCTGTGCAGTGGCTCTGTAATGC
TAACAAGAAGTCTGAAAACCCTGCCAAGCGCCTGTACTGCTTTTTTGCTTCTCTTTTTTCTGTTCTCGTCCGGGGATCCCGAGCTGTCCT
GCAGCTGTACCCTGAGAACTCAGAGCAGTTGGAGCTGATCACAACCCAGGCCACAAAGGCAGGCTTCTCCGGTGGCATGGTGGTAGACTA
CCCTAACAGTGCCAAAGCAAAGAAATTCTACCTCTGCTTGTTTTCTGGGCCTTCGACCTTTATACCAGAGGGGCTGAGTGAAAATCAGGA
TGAAGTTGAACCCAGGGAGTCTGTGTTCACCAATGAGAGGTTCCCATTAAGGATGTCGAGGCGGGGAATGGTGAGGAAGAGTCGGGCATG
GGTGCTGGAGAAGAAGGAGCGGCACAGGCGCCAGGGCAGAGTGGATCCGGGCTGCATGAGCCCAGATGTGAAGAATTCCATCCACGTCGG
AGACCGGATCTTGGAAATCAATGGCACGCCCATCCGAAATGTGCCCCTGGACGAGATTGACCTGCTGATTCAGGAAACCAGCCGCCTGCT
CCAGCTGACCCTCGAGCATGACCCTCACGATACACTGGGCCACGGGCTGGGGCCTGAGACCAGCCCCCTGAGCTCTCCGGCTTATACTCC
CAGCGGGGAGGCGGGCAGCTCTGCCCGGCAGAAACCTGTCTTGAGGAGCTGCAGCATCGACAGGTCTCCGGGCGCTGGCTCACTGGGCTC
CCCGGCCTCCCAGCGCAAGGACCTGGGTCGCTCTGAGTCCCTCCGCGTAGTCTGCCGGCCACACCGCATCTTCCGGCCGTCGGACCTCAT
CCACGGGGAGGTGCTGGGCAAGGGCTGCTTCGGCCAGGCTATCAAGGTGACACACCGTGAGACAGGTGAGGTGATGGTGATGAAGGAGCT
GATCCGGTTCGACGAGGAGACCCAGAGGACGTTCCTCAAGGAGGTGAAGGTCATGCGATGCCTGGAACACCCCAACGTGCTCAAGTTCAT
CGGGGTGCTCTACAAGGACAAGAGGCTCAACTTCATCACTGAGTACATCAAGGGCGGCACGCTCCGGGGCATCATCAAGAGCATGGACAG
CCAGTACCCATGGAGCCAGAGAGTGAGCTTTGCCAAGGACATCGCATCAGGGATGGCCTACCTCCACTCCATGAACATCATCCACCGAGA
CCTCAACTCCCACAACTGCCTGGTCCGCGAGAACAAGAATGTGGTGGTGGCTGACTTCGGGCTGGCGCGTCTCATGGTGGACGAGAAGAC
TCAGCCTGAGGGCCTGCGGAGCCTCAAGAAGCCAGACCGCAAGAAGCGCTACACCGTGGTGGGCAACCCCTACTGGATGGCACCTGAGAT
GATCAACGGCCGCAGCTATGATGAGAAGGTGGATGTGTTCTCCTTTGGGATCGTCCTGTGCGAGATCATCGGGCGGGTGAACGCAGACCC
TGACTACCTGCCCCGCACCATGGACTTTGGCCTCAACGTGCGAGGATTCCTGGACCGCTACTGCCCCCCAAACTGCCCCCCGAGCTTCTT
CCCCATCACCGTGCGCTGTTGCGATCTGGACCCCGAGAAGAGGCCATCCTTTGTGAAGCTGGAACACTGGCTGGAGACCCTCCGCATGCA
CCTGGCCGGCCACCTGCCACTGGGCCCACAGCTGGAGCAGCTGGACAGAGGTTTCTGGGAGACCTACCGGCGCGGCGAGAGCGGACTGCC
TGCCCACCCTGAGGTCCCCGACTGAGCCAGGGCCACTCAGCTGCCCCTGTCCCCACCTCTGGAGAATCCACCCCCACCAGATTCCTCCGC
GGGAGGTGGCCCTCAGCTGGGACAGTGGGGACCCAGGCTTCTCCTCAGAGCCAGGCCCTGACTTGCCTTCTCCCACCCCGTGGACCGCTT
CCCCTGCCTTCTCTCTGCCGTGGCCCAGAGCCGGCCCAGCTGCACACACACACCATGCTCTCGCCCTGCTGTAACCTCTGTCTTGGCAGG
GCTGTCCCCTCTTGCTTCTCCTTGCATGAGCTGGAGGGCCTGTGTGAGTTACGCCCCTTTCCACACGCCGCTGCCCCAGCAACCCTGTTC
ACGCTCCACCTGTCTGGTCCATAGCTCCCTGGAGGCTGGGCCAGGAGGCAGCCTCCGAACCATGCCCCATATAACGCTTGGGTGCGTGGG
AGGGCGCACATCAGGGCAGAGGCCAAGTTCCAGGTGTCTGTGTTCCCAGGAACCAAATGGGGAGTCTGGGGCCCGTTTTCCCCCCAGGGG
GTGTCTAGGTAGCAACAGGTATCGAGGACTCTCCAAACCCCCAAAGCAGAGAGAGGGCTGATCCCATGGGGCGGAGGTCCCCAGTGGCTG
AGCAAACAGCCCCTTCTCTCGCTTTGGGTCTTTTTTTTGTTTCTTTCTTAAAGCCACTTTAGTGAGAAGCAGGTACCAAGCCTCAGGGTG
AAGGGGGTCCCTTGAGGGAGCGTGGAGCTGCGGTGCCCTGGCCGGCGATGGGGAGGAGCCGGCTCCGGCAGTGAGAGGATAGGCACAGTG
GACCGGGCAGGTGTCCACCAGCAGCTCAGCCCCTGCAGTCATCTCAGAGCCCCTTCCCGGGCCTCTCCCCCAAGGCTCCCTGCCCCTCCT
CATGCCCCTCTGTCCTCTGCGTTTTTTCTGTGTAATCTATTTTTTAAGAAGAGTTTGTATTATTTTTTCATACGGCTGCAGCAGCAGCTG
CCAGGGGCTTGGGATTTTATTTTTGTGGCGGGCGGGGGTGGGAGGGCCATTTTGTCACTTTGCCTCAGTTGAGCATCTAGGAAGTATTAA
AACTGTGAAGCTTTCTCAGTGCACTTTGAACCTGGAAAACAATCCCAACAGGCCCGTGGGACCATGACTTAGGGAGGTGGGACCCACCCA

>98815_98815_1_WBSCR22-LIMK1_WBSCR22_chr7_73112024_ENST00000265758_LIMK1_chr7_73520205_ENST00000336180_length(amino acids)=708AA_BP=0
MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDE
AVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATK
AGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNERFPLRMSRRGMVRKSRAWVLEKKERHRRQGRVDPGCM
SPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSI
DRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMR
CLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADF
GLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDR

--------------------------------------------------------------
>98815_98815_2_WBSCR22-LIMK1_WBSCR22_chr7_73112024_ENST00000265758_LIMK1_chr7_73520205_ENST00000418310_length(transcript)=3409nt_BP=849nt
GACATAAAAACCGGGTGCCGGCAGGCGCCAGTCGCAGGTGTGCTGCTGAGGCGTGAGAATGGCGTCCCGCGGCCGGCGTCCGGAGCATGG
CGGACCCCCAGAGCTGTTTTATGACGAGACAGAAGCCCGGAAATACGTTCGCAACTCACGGATGATTGATATCCAGACCAGGATGGCTGG
GCGAGCATTGGAGCTTCTTTATCTGCCAGAGAATAAGCCCTGTTACCTGCTGGATATTGGCTGTGGCACTGGGCTGAGTGGAAGTTATCT
GTCAGATGAAGGGCACTATTGGGTGGGCCTGGATATCAGCCCTGCCATGCTGGATGAGGCTGTGGACCGAGAGATAGAGGGAGACCTGCT
GCTGGGGGATATGGGCCAGGGCATCCCATTCAAGCCAGGCACATTTGATGGTTGCATCAGCATTTCTGCTGTGCAGTGGCTCTGTAATGC
TAACAAGAAGTCTGAAAACCCTGCCAAGCGCCTGTACTGCTTTTTTGCTTCTCTTTTTTCTGTTCTCGTCCGGGGATCCCGAGCTGTCCT
GCAGCTGTACCCTGAGAACTCAGAGCAGTTGGAGCTGATCACAACCCAGGCCACAAAGGCAGGCTTCTCCGGTGGCATGGTGGTAGACTA
CCCTAACAGTGCCAAAGCAAAGAAATTCTACCTCTGCTTGTTTTCTGGGCCTTCGACCTTTATACCAGAGGGGCTGAGTGAAAATCAGGA
TGAAGTTGAACCCAGGGAGTCTGTGTTCACCAATGAGAGGTTCCCATTAAGGATGTCGAGGCGGGGAATGGTGAGGAAGAGTCGGGCATG
GGTGCTGGAGAAGAAGGAGCGGCACAGGCGCCAGGGCAGAGTGGATCCGGGCTGCATGAGCCCAGATGTGAAGAATTCCATCCACGTCGG
AGACCGGATCTTGGAAATCAATGGCACGCCCATCCGAAATGTGCCCCTGGACGAGATTGACCTGCTGATTCAGGAAACCAGCCGCCTGCT
CCAGCTGACCCTCGAGCATGACCCTCACGATACACTGGGCCACGGGCTGGGGCCTGAGACCAGCCCCCTGAGCTCTCCGGCTTATACTCC
CAGCGGGGAGGCGGGCAGCTCTGCCCGGCAGAAACCTGTCTTGAGGAGCTGCAGCATCGACAGGTCTCCGGGCGCTGGCTCACTGGGCTC
CCCGGCCTCCCAGCGCAAGGACCTGGGTCGCTCTGAGTCCCTCCGCGTAGTCTGCCGGCCACACCGCATCTTCCGGCCGTCGGACCTCAT
CCACGGGGAGGTGCTGGGCAAGGGCTGCTTCGGCCAGGCTATCAAGGTGACACACCGTGAGACAGGTGAGGTGATGGTGATGAAGGAGCT
GATCCGGTTCGACGAGGAGACCCAGAGGACGTTCCTCAAGGAGGTGAAGGTCATGCGATGCCTGGAACACCCCAACGTGCTCAAGTTCAT
CGGGGTGCTCTACAAGGACAAGAGGCTCAACTTCATCACTGAGTACATCAAGGGCGGCACGCTCCGGGGCATCATCAAGAGCATGGACAG
CCAGTACCCATGGAGCCAGAGAGTGAGCTTTGCCAAGGACATCGCATCAGGGATGGCCTACCTCCACTCCATGAACATCATCCACCGAGA
CCTCAACTCCCACAACTGCCTGGTCCGCGAGAACAAGAATGTGGTGGTGGCTGACTTCGGGCTGGCGCGTCTCATGGTGGACGAGAAGAC
TCAGCCTGAGGGCCTGCGGAGCCTCAAGAAGCCAGACCGCAAGAAGCGCTACACCGTGGTGGGCAACCCCTACTGGATGGCACCTGAGAT
GATCAACGGCCGCAGCTATGATGAGAAGGTGGATGTGTTCTCCTTTGGGATCGTCCTGTGCGAGATCATCGGGCGGGTGAACGCAGACCC
TGACTACCTGCCCCGCACCATGGACTTTGGCCTCAACGTGCGAGGATTCCTGGACCGCTACTGCCCCCCAAACTGCCCCCCGAGCTTCTT
CCCCATCACCGTGCGCTGTTGCGATCTGGACCCCGAGAAGAGGCCATCCTTTGTGAAGCTGGAACACTGGCTGGAGACCCTCCGCATGCA
CCTGGCCGGCCACCTGCCACTGGGCCCACAGCTGGAGCAGCTGGACAGAGGTTTCTGGGAGACCTACCGGCGCGGCGAGAGCGGACTGCC
TGCCCACCCTGAGGTCCCCGACTGAGCCAGGGCCACTCAGCTGCCCCTGTCCCCACCTCTGGAGAATCCACCCCCACCAGATTCCTCCGC
GGGAGGTGGCCCTCAGCTGGGACAGTGGGGACCCAGGCTTCTCCTCAGAGCCAGGCCCTGACTTGCCTTCTCCCACCCCGTGGACCGCTT
CCCCTGCCTTCTCTCTGCCGTGGCCCAGAGCCGGCCCAGCTGCACACACACACCATGCTCTCGCCCTGCTGTAACCTCTGTCTTGGCAGG
GCTGTCCCCTCTTGCTTCTCCTTGCATGAGCTGGAGGGCCTGTGTGAGTTACGCCCCTTTCCACACGCCGCTGCCCCAGCAACCCTGTTC
ACGCTCCACCTGTCTGGTCCATAGCTCCCTGGAGGCTGGGCCAGGAGGCAGCCTCCGAACCATGCCCCATATAACGCTTGGGTGCGTGGG
AGGGCGCACATCAGGGCAGAGGCCAAGTTCCAGGTGTCTGTGTTCCCAGGAACCAAATGGGGAGTCTGGGGCCCGTTTTCCCCCCAGGGG
GTGTCTAGGTAGCAACAGGTATCGAGGACTCTCCAAACCCCCAAAGCAGAGAGAGGGCTGATCCCATGGGGCGGAGGTCCCCAGTGGCTG
AGCAAACAGCCCCTTCTCTCGCTTTGGGTCTTTTTTTTGTTTCTTTCTTAAAGCCACTTTAGTGAGAAGCAGGTACCAAGCCTCAGGGTG
AAGGGGGTCCCTTGAGGGAGCGTGGAGCTGCGGTGCCCTGGCCGGCGATGGGGAGGAGCCGGCTCCGGCAGTGAGAGGATAGGCACAGTG
GACCGGGCAGGTGTCCACCAGCAGCTCAGCCCCTGCAGTCATCTCAGAGCCCCTTCCCGGGCCTCTCCCCCAAGGCTCCCTGCCCCTCCT
CATGCCCCTCTGTCCTCTGCGTTTTTTCTGTGTAATCTATTTTTTAAGAAGAGTTTGTATTATTTTTTCATACGGCTGCAGCAGCAGCTG
CCAGGGGCTTGGGATTTTATTTTTGTGGCGGGCGGGGGTGGGAGGGCCATTTTGTCACTTTGCCTCAGTTGAGCATCTAGGAAGTATTAA
AACTGTGAAGCTTTCTCAGTGCACTTTGAACCTGGAAAACAATCCCAACAGGCCCGTGGGACCATGACTTAGGGAGGTGGGACCCACCCA

>98815_98815_2_WBSCR22-LIMK1_WBSCR22_chr7_73112024_ENST00000265758_LIMK1_chr7_73520205_ENST00000418310_length(amino acids)=708AA_BP=0
MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDE
AVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATK
AGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNERFPLRMSRRGMVRKSRAWVLEKKERHRRQGRVDPGCM
SPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSI
DRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMR
CLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADF
GLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDR

--------------------------------------------------------------
>98815_98815_3_WBSCR22-LIMK1_WBSCR22_chr7_73112024_ENST00000265758_LIMK1_chr7_73520205_ENST00000538333_length(transcript)=2342nt_BP=849nt
GACATAAAAACCGGGTGCCGGCAGGCGCCAGTCGCAGGTGTGCTGCTGAGGCGTGAGAATGGCGTCCCGCGGCCGGCGTCCGGAGCATGG
CGGACCCCCAGAGCTGTTTTATGACGAGACAGAAGCCCGGAAATACGTTCGCAACTCACGGATGATTGATATCCAGACCAGGATGGCTGG
GCGAGCATTGGAGCTTCTTTATCTGCCAGAGAATAAGCCCTGTTACCTGCTGGATATTGGCTGTGGCACTGGGCTGAGTGGAAGTTATCT
GTCAGATGAAGGGCACTATTGGGTGGGCCTGGATATCAGCCCTGCCATGCTGGATGAGGCTGTGGACCGAGAGATAGAGGGAGACCTGCT
GCTGGGGGATATGGGCCAGGGCATCCCATTCAAGCCAGGCACATTTGATGGTTGCATCAGCATTTCTGCTGTGCAGTGGCTCTGTAATGC
TAACAAGAAGTCTGAAAACCCTGCCAAGCGCCTGTACTGCTTTTTTGCTTCTCTTTTTTCTGTTCTCGTCCGGGGATCCCGAGCTGTCCT
GCAGCTGTACCCTGAGAACTCAGAGCAGTTGGAGCTGATCACAACCCAGGCCACAAAGGCAGGCTTCTCCGGTGGCATGGTGGTAGACTA
CCCTAACAGTGCCAAAGCAAAGAAATTCTACCTCTGCTTGTTTTCTGGGCCTTCGACCTTTATACCAGAGGGGCTGAGTGAAAATCAGGA
TGAAGTTGAACCCAGGGAGTCTGTGTTCACCAATGAGAGGTTCCCATTAAGGATGTCGAGGCGGGGAATGGTGAGGAAGAGTCGGGCATG
GGTGCTGGAGAAGAAGGAGCGGCACAGGCGCCAGGGCAGAGTGGATCCGGGCTGCATGAGCCCAGATGTGAAGAATTCCATCCACGTCGG
AGACCGGATCTTGGAAATCAATGGCACGCCCATCCGAAATGTGCCCCTGGACGAGATTGACCTGCTGATTCAGGAAACCAGCCGCCTGCT
CCAGCTGACCCTCGAGCATGACCCTCACGATACACTGGGCCACGGGCTGGGGCCTGAGACCAGCCCCCTGAGCTCTCCGGCTTATACTCC
CAGCGGGGAGGCGGGCAGCTCTGCCCGGCAGAAACCTGTCTTGAGGAGCTGCAGCATCGACAGGTCTCCGGGCGCTGGCTCACTGGGCTC
CCCGGCCTCCCAGCGCAAGGACCTGGGTCGCTCTGAGTCCCTCCGCGTAGTCTGCCGGCCACACCGCATCTTCCGGCCGTCGGACCTCAT
CCACGGGGAGGTGCTGGGCAAGGGCTGCTTCGGCCAGGCTATCAAGGTGACACACCGTGAGACAGGTGAGGTGATGGTGATGAAGGAGCT
GATCCGGTTCGACGAGGAGACCCAGAGGACGTTCCTCAAGGAGGTGAAGGTCATGCGATGCCTGGAACACCCCAACGTGCTCAAGTTCAT
CGGGGTGCTCTACAAGGACAAGAGGCTCAACTTCATCACTGAGTACATCAAGGGCGGCACGCTCCGGGGCATCATCAAGAGCATGGACAG
CCAGTACCCATGGAGCCAGAGAGTGAGCTTTGCCAAGGACATCGCATCAGGGATGGCCTACCTCCACTCCATGAACATCATCCACCGAGA
CCTCAACTCCCACAACTGCCTGGTCCGCGAGAACAAGAATGTGGTGGTGGCTGACTTCGGGCTGGCGCGTCTCATGGTGGACGAGAAGAC
TCAGCCTGAGGGCCTGCGGAGCCTCAAGAAGCCAGACCGCAAGAAGCGCTACACCGTGGTGGGCAACCCCTACTGGATGGCACCTGAGAT
GATCAACGGCCGCAGCTATGATGAGAAGGTGGATGTGTTCTCCTTTGGGATCGTCCTGTGCGAGATCATCGGGCGGGTGAACGCAGACCC
TGACTACCTGCCCCGCACCATGGACTTTGGCCTCAACGTGCGAGGATTCCTGGACCGCTACTGCCCCCCAAACTGCCCCCCGAGCTTCTT
CCCCATCACCGTGCGCTGTTGCGATCTGGACCCCGAGAAGAGGCCATCCTTTGTGAAGCTGGAACACTGGCTGGAGACCCTCCGCATGCA
CCTGGCCGGCCACCTGCCACTGGGCCCACAGCTGGAGCAGCTGGACAGAGGTTTCTGGGAGACCTACCGGCGCGGCGAGAGCGGACTGCC
TGCCCACCCTGAGGTCCCCGACTGAGCCAGGGCCACTCAGCTGCCCCTGTCCCCACCTCTGGAGAATCCACCCCCACCAGATTCCTCCGC
GGGAGGTGGCCCTCAGCTGGGACAGTGGGGACCCAGGCTTCTCCTCAGAGCCAGGCCCTGACTTGCCTTCTCCCACCCCGTGGACCGCTT

>98815_98815_3_WBSCR22-LIMK1_WBSCR22_chr7_73112024_ENST00000265758_LIMK1_chr7_73520205_ENST00000538333_length(amino acids)=708AA_BP=0
MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDE
AVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATK
AGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNERFPLRMSRRGMVRKSRAWVLEKKERHRRQGRVDPGCM
SPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSI
DRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMR
CLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADF
GLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDR

--------------------------------------------------------------
>98815_98815_4_WBSCR22-LIMK1_WBSCR22_chr7_73112024_ENST00000423497_LIMK1_chr7_73520205_ENST00000336180_length(transcript)=3402nt_BP=842nt
ATGGCGTCCCGCGGCCGGCGTCCGGAGCATGGCGGACCCCCAGAGCTGTTTTATGACGAGACAGAAGCCCGGAAATACGTTCGCAACTCA
CGGATGATTGATATCCAGACCAGGATGGCTGGGCGAGCATTGGAGCTTCTTTATCTGCCAGAGAATAAGCCCTGTTACCTGCTGGATATT
GGCTGTGGCACTGGGCTGAGTGGAAGTTATCTGTCAGATGAAGGGCACTATTGGGTGGGCCTGGATATCAGCCCTGCCATGCTGGATGAG
GCTGTGGACCGAGAGATAGAGGGAGACCTGCTGCTGGGGGATATGGGCCAGGGCATCCCATTCAAGCCAGGCACATTTGATGGTTGCATC
AGCATTTCTGCTGTGCAGTGGCTCTGTAATGCTAACAAGAAGTCTGAAAACCCTGCCAAGCGCCTGTACTGCTTTTTTGCTTCTCTTTTT
TCTGTTCTCGTCCGGGGATCCCGAGCTGTCCTGCAGCTGTACCCTGAGAACTCAGAGCAGTTGGAGCTGATCACAACCCAGGCCACAAAG
GCAGGCTTCTCCGGTGGCATGGTGGTAGACTACCCTAACAGTGCCAAAGCAAAGAAATTCTACCTCTGCTTGTTTTCTGGGCCTTCGACC
TTTATACCAGAGGGGCTGAGTGAAAATCAGGATGAAGTTGAACCCAGGGAGTCTGTGTTCACCAATGAGAGGGAAGGTGGAGCATTTGAG
AGAAGGGGCATCCGAGGCCACCAGACTCGGAGGTTCCCATTAAGGATGTCGAGGCGGGGAATGGTGAGGAAGAGTCGGGCATGGGTGCTG
GAGAAGAAGGAGCGGCACAGGCGCCAGGGCAGAGTGGATCCGGGCTGCATGAGCCCAGATGTGAAGAATTCCATCCACGTCGGAGACCGG
ATCTTGGAAATCAATGGCACGCCCATCCGAAATGTGCCCCTGGACGAGATTGACCTGCTGATTCAGGAAACCAGCCGCCTGCTCCAGCTG
ACCCTCGAGCATGACCCTCACGATACACTGGGCCACGGGCTGGGGCCTGAGACCAGCCCCCTGAGCTCTCCGGCTTATACTCCCAGCGGG
GAGGCGGGCAGCTCTGCCCGGCAGAAACCTGTCTTGAGGAGCTGCAGCATCGACAGGTCTCCGGGCGCTGGCTCACTGGGCTCCCCGGCC
TCCCAGCGCAAGGACCTGGGTCGCTCTGAGTCCCTCCGCGTAGTCTGCCGGCCACACCGCATCTTCCGGCCGTCGGACCTCATCCACGGG
GAGGTGCTGGGCAAGGGCTGCTTCGGCCAGGCTATCAAGGTGACACACCGTGAGACAGGTGAGGTGATGGTGATGAAGGAGCTGATCCGG
TTCGACGAGGAGACCCAGAGGACGTTCCTCAAGGAGGTGAAGGTCATGCGATGCCTGGAACACCCCAACGTGCTCAAGTTCATCGGGGTG
CTCTACAAGGACAAGAGGCTCAACTTCATCACTGAGTACATCAAGGGCGGCACGCTCCGGGGCATCATCAAGAGCATGGACAGCCAGTAC
CCATGGAGCCAGAGAGTGAGCTTTGCCAAGGACATCGCATCAGGGATGGCCTACCTCCACTCCATGAACATCATCCACCGAGACCTCAAC
TCCCACAACTGCCTGGTCCGCGAGAACAAGAATGTGGTGGTGGCTGACTTCGGGCTGGCGCGTCTCATGGTGGACGAGAAGACTCAGCCT
GAGGGCCTGCGGAGCCTCAAGAAGCCAGACCGCAAGAAGCGCTACACCGTGGTGGGCAACCCCTACTGGATGGCACCTGAGATGATCAAC
GGCCGCAGCTATGATGAGAAGGTGGATGTGTTCTCCTTTGGGATCGTCCTGTGCGAGATCATCGGGCGGGTGAACGCAGACCCTGACTAC
CTGCCCCGCACCATGGACTTTGGCCTCAACGTGCGAGGATTCCTGGACCGCTACTGCCCCCCAAACTGCCCCCCGAGCTTCTTCCCCATC
ACCGTGCGCTGTTGCGATCTGGACCCCGAGAAGAGGCCATCCTTTGTGAAGCTGGAACACTGGCTGGAGACCCTCCGCATGCACCTGGCC
GGCCACCTGCCACTGGGCCCACAGCTGGAGCAGCTGGACAGAGGTTTCTGGGAGACCTACCGGCGCGGCGAGAGCGGACTGCCTGCCCAC
CCTGAGGTCCCCGACTGAGCCAGGGCCACTCAGCTGCCCCTGTCCCCACCTCTGGAGAATCCACCCCCACCAGATTCCTCCGCGGGAGGT
GGCCCTCAGCTGGGACAGTGGGGACCCAGGCTTCTCCTCAGAGCCAGGCCCTGACTTGCCTTCTCCCACCCCGTGGACCGCTTCCCCTGC
CTTCTCTCTGCCGTGGCCCAGAGCCGGCCCAGCTGCACACACACACCATGCTCTCGCCCTGCTGTAACCTCTGTCTTGGCAGGGCTGTCC
CCTCTTGCTTCTCCTTGCATGAGCTGGAGGGCCTGTGTGAGTTACGCCCCTTTCCACACGCCGCTGCCCCAGCAACCCTGTTCACGCTCC
ACCTGTCTGGTCCATAGCTCCCTGGAGGCTGGGCCAGGAGGCAGCCTCCGAACCATGCCCCATATAACGCTTGGGTGCGTGGGAGGGCGC
ACATCAGGGCAGAGGCCAAGTTCCAGGTGTCTGTGTTCCCAGGAACCAAATGGGGAGTCTGGGGCCCGTTTTCCCCCCAGGGGGTGTCTA
GGTAGCAACAGGTATCGAGGACTCTCCAAACCCCCAAAGCAGAGAGAGGGCTGATCCCATGGGGCGGAGGTCCCCAGTGGCTGAGCAAAC
AGCCCCTTCTCTCGCTTTGGGTCTTTTTTTTGTTTCTTTCTTAAAGCCACTTTAGTGAGAAGCAGGTACCAAGCCTCAGGGTGAAGGGGG
TCCCTTGAGGGAGCGTGGAGCTGCGGTGCCCTGGCCGGCGATGGGGAGGAGCCGGCTCCGGCAGTGAGAGGATAGGCACAGTGGACCGGG
CAGGTGTCCACCAGCAGCTCAGCCCCTGCAGTCATCTCAGAGCCCCTTCCCGGGCCTCTCCCCCAAGGCTCCCTGCCCCTCCTCATGCCC
CTCTGTCCTCTGCGTTTTTTCTGTGTAATCTATTTTTTAAGAAGAGTTTGTATTATTTTTTCATACGGCTGCAGCAGCAGCTGCCAGGGG
CTTGGGATTTTATTTTTGTGGCGGGCGGGGGTGGGAGGGCCATTTTGTCACTTTGCCTCAGTTGAGCATCTAGGAAGTATTAAAACTGTG
AAGCTTTCTCAGTGCACTTTGAACCTGGAAAACAATCCCAACAGGCCCGTGGGACCATGACTTAGGGAGGTGGGACCCACCCACCCCCAT

>98815_98815_4_WBSCR22-LIMK1_WBSCR22_chr7_73112024_ENST00000423497_LIMK1_chr7_73520205_ENST00000336180_length(amino acids)=725AA_BP=0
MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDE
AVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATK
AGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNEREGGAFERRGIRGHQTRRFPLRMSRRGMVRKSRAWVL
EKKERHRRQGRVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSG
EAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR
FDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLN
SHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDY
LPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAH

--------------------------------------------------------------
>98815_98815_5_WBSCR22-LIMK1_WBSCR22_chr7_73112024_ENST00000423497_LIMK1_chr7_73520205_ENST00000418310_length(transcript)=3402nt_BP=842nt
ATGGCGTCCCGCGGCCGGCGTCCGGAGCATGGCGGACCCCCAGAGCTGTTTTATGACGAGACAGAAGCCCGGAAATACGTTCGCAACTCA
CGGATGATTGATATCCAGACCAGGATGGCTGGGCGAGCATTGGAGCTTCTTTATCTGCCAGAGAATAAGCCCTGTTACCTGCTGGATATT
GGCTGTGGCACTGGGCTGAGTGGAAGTTATCTGTCAGATGAAGGGCACTATTGGGTGGGCCTGGATATCAGCCCTGCCATGCTGGATGAG
GCTGTGGACCGAGAGATAGAGGGAGACCTGCTGCTGGGGGATATGGGCCAGGGCATCCCATTCAAGCCAGGCACATTTGATGGTTGCATC
AGCATTTCTGCTGTGCAGTGGCTCTGTAATGCTAACAAGAAGTCTGAAAACCCTGCCAAGCGCCTGTACTGCTTTTTTGCTTCTCTTTTT
TCTGTTCTCGTCCGGGGATCCCGAGCTGTCCTGCAGCTGTACCCTGAGAACTCAGAGCAGTTGGAGCTGATCACAACCCAGGCCACAAAG
GCAGGCTTCTCCGGTGGCATGGTGGTAGACTACCCTAACAGTGCCAAAGCAAAGAAATTCTACCTCTGCTTGTTTTCTGGGCCTTCGACC
TTTATACCAGAGGGGCTGAGTGAAAATCAGGATGAAGTTGAACCCAGGGAGTCTGTGTTCACCAATGAGAGGGAAGGTGGAGCATTTGAG
AGAAGGGGCATCCGAGGCCACCAGACTCGGAGGTTCCCATTAAGGATGTCGAGGCGGGGAATGGTGAGGAAGAGTCGGGCATGGGTGCTG
GAGAAGAAGGAGCGGCACAGGCGCCAGGGCAGAGTGGATCCGGGCTGCATGAGCCCAGATGTGAAGAATTCCATCCACGTCGGAGACCGG
ATCTTGGAAATCAATGGCACGCCCATCCGAAATGTGCCCCTGGACGAGATTGACCTGCTGATTCAGGAAACCAGCCGCCTGCTCCAGCTG
ACCCTCGAGCATGACCCTCACGATACACTGGGCCACGGGCTGGGGCCTGAGACCAGCCCCCTGAGCTCTCCGGCTTATACTCCCAGCGGG
GAGGCGGGCAGCTCTGCCCGGCAGAAACCTGTCTTGAGGAGCTGCAGCATCGACAGGTCTCCGGGCGCTGGCTCACTGGGCTCCCCGGCC
TCCCAGCGCAAGGACCTGGGTCGCTCTGAGTCCCTCCGCGTAGTCTGCCGGCCACACCGCATCTTCCGGCCGTCGGACCTCATCCACGGG
GAGGTGCTGGGCAAGGGCTGCTTCGGCCAGGCTATCAAGGTGACACACCGTGAGACAGGTGAGGTGATGGTGATGAAGGAGCTGATCCGG
TTCGACGAGGAGACCCAGAGGACGTTCCTCAAGGAGGTGAAGGTCATGCGATGCCTGGAACACCCCAACGTGCTCAAGTTCATCGGGGTG
CTCTACAAGGACAAGAGGCTCAACTTCATCACTGAGTACATCAAGGGCGGCACGCTCCGGGGCATCATCAAGAGCATGGACAGCCAGTAC
CCATGGAGCCAGAGAGTGAGCTTTGCCAAGGACATCGCATCAGGGATGGCCTACCTCCACTCCATGAACATCATCCACCGAGACCTCAAC
TCCCACAACTGCCTGGTCCGCGAGAACAAGAATGTGGTGGTGGCTGACTTCGGGCTGGCGCGTCTCATGGTGGACGAGAAGACTCAGCCT
GAGGGCCTGCGGAGCCTCAAGAAGCCAGACCGCAAGAAGCGCTACACCGTGGTGGGCAACCCCTACTGGATGGCACCTGAGATGATCAAC
GGCCGCAGCTATGATGAGAAGGTGGATGTGTTCTCCTTTGGGATCGTCCTGTGCGAGATCATCGGGCGGGTGAACGCAGACCCTGACTAC
CTGCCCCGCACCATGGACTTTGGCCTCAACGTGCGAGGATTCCTGGACCGCTACTGCCCCCCAAACTGCCCCCCGAGCTTCTTCCCCATC
ACCGTGCGCTGTTGCGATCTGGACCCCGAGAAGAGGCCATCCTTTGTGAAGCTGGAACACTGGCTGGAGACCCTCCGCATGCACCTGGCC
GGCCACCTGCCACTGGGCCCACAGCTGGAGCAGCTGGACAGAGGTTTCTGGGAGACCTACCGGCGCGGCGAGAGCGGACTGCCTGCCCAC
CCTGAGGTCCCCGACTGAGCCAGGGCCACTCAGCTGCCCCTGTCCCCACCTCTGGAGAATCCACCCCCACCAGATTCCTCCGCGGGAGGT
GGCCCTCAGCTGGGACAGTGGGGACCCAGGCTTCTCCTCAGAGCCAGGCCCTGACTTGCCTTCTCCCACCCCGTGGACCGCTTCCCCTGC
CTTCTCTCTGCCGTGGCCCAGAGCCGGCCCAGCTGCACACACACACCATGCTCTCGCCCTGCTGTAACCTCTGTCTTGGCAGGGCTGTCC
CCTCTTGCTTCTCCTTGCATGAGCTGGAGGGCCTGTGTGAGTTACGCCCCTTTCCACACGCCGCTGCCCCAGCAACCCTGTTCACGCTCC
ACCTGTCTGGTCCATAGCTCCCTGGAGGCTGGGCCAGGAGGCAGCCTCCGAACCATGCCCCATATAACGCTTGGGTGCGTGGGAGGGCGC
ACATCAGGGCAGAGGCCAAGTTCCAGGTGTCTGTGTTCCCAGGAACCAAATGGGGAGTCTGGGGCCCGTTTTCCCCCCAGGGGGTGTCTA
GGTAGCAACAGGTATCGAGGACTCTCCAAACCCCCAAAGCAGAGAGAGGGCTGATCCCATGGGGCGGAGGTCCCCAGTGGCTGAGCAAAC
AGCCCCTTCTCTCGCTTTGGGTCTTTTTTTTGTTTCTTTCTTAAAGCCACTTTAGTGAGAAGCAGGTACCAAGCCTCAGGGTGAAGGGGG
TCCCTTGAGGGAGCGTGGAGCTGCGGTGCCCTGGCCGGCGATGGGGAGGAGCCGGCTCCGGCAGTGAGAGGATAGGCACAGTGGACCGGG
CAGGTGTCCACCAGCAGCTCAGCCCCTGCAGTCATCTCAGAGCCCCTTCCCGGGCCTCTCCCCCAAGGCTCCCTGCCCCTCCTCATGCCC
CTCTGTCCTCTGCGTTTTTTCTGTGTAATCTATTTTTTAAGAAGAGTTTGTATTATTTTTTCATACGGCTGCAGCAGCAGCTGCCAGGGG
CTTGGGATTTTATTTTTGTGGCGGGCGGGGGTGGGAGGGCCATTTTGTCACTTTGCCTCAGTTGAGCATCTAGGAAGTATTAAAACTGTG
AAGCTTTCTCAGTGCACTTTGAACCTGGAAAACAATCCCAACAGGCCCGTGGGACCATGACTTAGGGAGGTGGGACCCACCCACCCCCAT

>98815_98815_5_WBSCR22-LIMK1_WBSCR22_chr7_73112024_ENST00000423497_LIMK1_chr7_73520205_ENST00000418310_length(amino acids)=725AA_BP=0
MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDE
AVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATK
AGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNEREGGAFERRGIRGHQTRRFPLRMSRRGMVRKSRAWVL
EKKERHRRQGRVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSG
EAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR
FDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLN
SHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDY
LPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAH

--------------------------------------------------------------
>98815_98815_6_WBSCR22-LIMK1_WBSCR22_chr7_73112024_ENST00000423497_LIMK1_chr7_73520205_ENST00000538333_length(transcript)=2335nt_BP=842nt
ATGGCGTCCCGCGGCCGGCGTCCGGAGCATGGCGGACCCCCAGAGCTGTTTTATGACGAGACAGAAGCCCGGAAATACGTTCGCAACTCA
CGGATGATTGATATCCAGACCAGGATGGCTGGGCGAGCATTGGAGCTTCTTTATCTGCCAGAGAATAAGCCCTGTTACCTGCTGGATATT
GGCTGTGGCACTGGGCTGAGTGGAAGTTATCTGTCAGATGAAGGGCACTATTGGGTGGGCCTGGATATCAGCCCTGCCATGCTGGATGAG
GCTGTGGACCGAGAGATAGAGGGAGACCTGCTGCTGGGGGATATGGGCCAGGGCATCCCATTCAAGCCAGGCACATTTGATGGTTGCATC
AGCATTTCTGCTGTGCAGTGGCTCTGTAATGCTAACAAGAAGTCTGAAAACCCTGCCAAGCGCCTGTACTGCTTTTTTGCTTCTCTTTTT
TCTGTTCTCGTCCGGGGATCCCGAGCTGTCCTGCAGCTGTACCCTGAGAACTCAGAGCAGTTGGAGCTGATCACAACCCAGGCCACAAAG
GCAGGCTTCTCCGGTGGCATGGTGGTAGACTACCCTAACAGTGCCAAAGCAAAGAAATTCTACCTCTGCTTGTTTTCTGGGCCTTCGACC
TTTATACCAGAGGGGCTGAGTGAAAATCAGGATGAAGTTGAACCCAGGGAGTCTGTGTTCACCAATGAGAGGGAAGGTGGAGCATTTGAG
AGAAGGGGCATCCGAGGCCACCAGACTCGGAGGTTCCCATTAAGGATGTCGAGGCGGGGAATGGTGAGGAAGAGTCGGGCATGGGTGCTG
GAGAAGAAGGAGCGGCACAGGCGCCAGGGCAGAGTGGATCCGGGCTGCATGAGCCCAGATGTGAAGAATTCCATCCACGTCGGAGACCGG
ATCTTGGAAATCAATGGCACGCCCATCCGAAATGTGCCCCTGGACGAGATTGACCTGCTGATTCAGGAAACCAGCCGCCTGCTCCAGCTG
ACCCTCGAGCATGACCCTCACGATACACTGGGCCACGGGCTGGGGCCTGAGACCAGCCCCCTGAGCTCTCCGGCTTATACTCCCAGCGGG
GAGGCGGGCAGCTCTGCCCGGCAGAAACCTGTCTTGAGGAGCTGCAGCATCGACAGGTCTCCGGGCGCTGGCTCACTGGGCTCCCCGGCC
TCCCAGCGCAAGGACCTGGGTCGCTCTGAGTCCCTCCGCGTAGTCTGCCGGCCACACCGCATCTTCCGGCCGTCGGACCTCATCCACGGG
GAGGTGCTGGGCAAGGGCTGCTTCGGCCAGGCTATCAAGGTGACACACCGTGAGACAGGTGAGGTGATGGTGATGAAGGAGCTGATCCGG
TTCGACGAGGAGACCCAGAGGACGTTCCTCAAGGAGGTGAAGGTCATGCGATGCCTGGAACACCCCAACGTGCTCAAGTTCATCGGGGTG
CTCTACAAGGACAAGAGGCTCAACTTCATCACTGAGTACATCAAGGGCGGCACGCTCCGGGGCATCATCAAGAGCATGGACAGCCAGTAC
CCATGGAGCCAGAGAGTGAGCTTTGCCAAGGACATCGCATCAGGGATGGCCTACCTCCACTCCATGAACATCATCCACCGAGACCTCAAC
TCCCACAACTGCCTGGTCCGCGAGAACAAGAATGTGGTGGTGGCTGACTTCGGGCTGGCGCGTCTCATGGTGGACGAGAAGACTCAGCCT
GAGGGCCTGCGGAGCCTCAAGAAGCCAGACCGCAAGAAGCGCTACACCGTGGTGGGCAACCCCTACTGGATGGCACCTGAGATGATCAAC
GGCCGCAGCTATGATGAGAAGGTGGATGTGTTCTCCTTTGGGATCGTCCTGTGCGAGATCATCGGGCGGGTGAACGCAGACCCTGACTAC
CTGCCCCGCACCATGGACTTTGGCCTCAACGTGCGAGGATTCCTGGACCGCTACTGCCCCCCAAACTGCCCCCCGAGCTTCTTCCCCATC
ACCGTGCGCTGTTGCGATCTGGACCCCGAGAAGAGGCCATCCTTTGTGAAGCTGGAACACTGGCTGGAGACCCTCCGCATGCACCTGGCC
GGCCACCTGCCACTGGGCCCACAGCTGGAGCAGCTGGACAGAGGTTTCTGGGAGACCTACCGGCGCGGCGAGAGCGGACTGCCTGCCCAC
CCTGAGGTCCCCGACTGAGCCAGGGCCACTCAGCTGCCCCTGTCCCCACCTCTGGAGAATCCACCCCCACCAGATTCCTCCGCGGGAGGT

>98815_98815_6_WBSCR22-LIMK1_WBSCR22_chr7_73112024_ENST00000423497_LIMK1_chr7_73520205_ENST00000538333_length(amino acids)=725AA_BP=0
MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDE
AVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATK
AGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNEREGGAFERRGIRGHQTRRFPLRMSRRGMVRKSRAWVL
EKKERHRRQGRVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSG
EAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR
FDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLN
SHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDY
LPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WBSCR22-LIMK1


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HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WBSCR22-LIMK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WBSCR22-LIMK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource