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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BMP7-PIGU (FusionGDB2 ID:9885)

Fusion Gene Summary for BMP7-PIGU

Fusion gene summary

Fusion gene information	Fusion gene name: BMP7-PIGU
	Fusion gene ID: 9885
		Hgene	Tgene
	Gene symbol	BMP7	PIGU
	Gene ID	655	128869
	Gene name	bone morphogenetic protein 7	phosphatidylinositol glycan anchor biosynthesis class U
	Synonyms	OP-1	CDC91L1\|GAB1\|GPIBD21
	Cytomap	20q13.31	20q11.22
	Type of gene	protein-coding	protein-coding
	Description	bone morphogenetic protein 7osteogenic protein 1	phosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI transamidase component PIG-UGPI transamidase subunitcell division cycle 91-like 1 proteincell division cycle protein 91-li
	Modification date	20200327	20200322
	UniProtAcc	P18075	.
	Ensembl transtripts involved in fusion gene	ENST00000395863, ENST00000395864, ENST00000450594, ENST00000460817,	ENST00000480175, ENST00000374820, ENST00000452740,
Fusion gene scores	* DoF score	11 X 10 X 6=660	19 X 15 X 11=3135
	# samples	13	21
	** MAII score	log2(13/660*10)=-2.34395440121736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/3135*10)=-3.90000421002328 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BMP7 [Title/Abstract] AND PIGU [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BMP7(55840761)-PIGU(33176411), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BMP7	GO:0010628	positive regulation of gene expression	28124060
Hgene	BMP7	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	19736306
Hgene	BMP7	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	9311995\|16049014\|17244894\|19736306
Hgene	BMP7	GO:0030501	positive regulation of bone mineralization	18436533
Hgene	BMP7	GO:0030509	BMP signaling pathway	16049014\|18436533
Hgene	BMP7	GO:0034116	positive regulation of heterotypic cell-cell adhesion	15100360
Hgene	BMP7	GO:0034504	protein localization to nucleus	17244894
Hgene	BMP7	GO:0042326	negative regulation of phosphorylation	17244894
Hgene	BMP7	GO:0043407	negative regulation of MAP kinase activity	17244894
Hgene	BMP7	GO:0045665	negative regulation of neuron differentiation	16325379
Hgene	BMP7	GO:0045669	positive regulation of osteoblast differentiation	18436533
Hgene	BMP7	GO:0045786	negative regulation of cell cycle	11502704
Hgene	BMP7	GO:0045839	negative regulation of mitotic nuclear division	17244894
Hgene	BMP7	GO:0045892	negative regulation of transcription, DNA-templated	15100360\|17244894
Hgene	BMP7	GO:0045893	positive regulation of transcription, DNA-templated	14517293\|15100360\|16049014
Hgene	BMP7	GO:0048762	mesenchymal cell differentiation	9693150
Hgene	BMP7	GO:0048812	neuron projection morphogenesis	16325379
Hgene	BMP7	GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	16049014
Hgene	BMP7	GO:0060395	SMAD protein signal transduction	17244894
Hgene	BMP7	GO:0060548	negative regulation of cell death	12631064
Hgene	BMP7	GO:0070487	monocyte aggregation	15100360
Hgene	BMP7	GO:0072125	negative regulation of glomerular mesangial cell proliferation	17244894
Hgene	BMP7	GO:1900006	positive regulation of dendrite development	11580864
Hgene	BMP7	GO:1900106	positive regulation of hyaluranon cable assembly	15100360
Tgene	PIGU	GO:0006506	GPI anchor biosynthetic process	15034568
Tgene	PIGU	GO:0046425	regulation of JAK-STAT cascade	15034568

Fusion gene breakpoints across BMP7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PIGU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-85-8664-01A	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-
ChimerDB4	LUSC	TCGA-85-8664	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-

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Fusion Gene ORF analysis for BMP7-PIGU

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000395863	ENST00000480175	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-
5CDS-5UTR	ENST00000395864	ENST00000480175	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-
5CDS-5UTR	ENST00000450594	ENST00000480175	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-
In-frame	ENST00000395863	ENST00000374820	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-
In-frame	ENST00000395863	ENST00000452740	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-
In-frame	ENST00000395864	ENST00000374820	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-
In-frame	ENST00000395864	ENST00000452740	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-
In-frame	ENST00000450594	ENST00000374820	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-
In-frame	ENST00000450594	ENST00000452740	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-
intron-3CDS	ENST00000460817	ENST00000374820	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-
intron-3CDS	ENST00000460817	ENST00000452740	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-
intron-5UTR	ENST00000460817	ENST00000480175	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000395863	BMP7	chr20	55840761	-	ENST00000374820	PIGU	chr20	33176411	-	1928	924	77	1144	355
ENST00000395863	BMP7	chr20	55840761	-	ENST00000452740	PIGU	chr20	33176411	-	1766	924	77	1144	355
ENST00000395864	BMP7	chr20	55840761	-	ENST00000374820	PIGU	chr20	33176411	-	1642	638	115	858	247
ENST00000395864	BMP7	chr20	55840761	-	ENST00000452740	PIGU	chr20	33176411	-	1480	638	115	858	247
ENST00000450594	BMP7	chr20	55840761	-	ENST00000374820	PIGU	chr20	33176411	-	1929	925	78	1145	355
ENST00000450594	BMP7	chr20	55840761	-	ENST00000452740	PIGU	chr20	33176411	-	1767	925	78	1145	355

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000395863	ENST00000374820	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-	0.07227123	0.9277288
ENST00000395863	ENST00000452740	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-	0.21788819	0.78211176
ENST00000395864	ENST00000374820	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-	0.071324036	0.92867595
ENST00000395864	ENST00000452740	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-	0.1986404	0.8013596
ENST00000450594	ENST00000374820	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-	0.07447317	0.92552686
ENST00000450594	ENST00000452740	BMP7	chr20	55840761	-	PIGU	chr20	33176411	-	0.21658686	0.7834132

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Fusion Genomic Features for BMP7-PIGU

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BMP7-PIGU

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:55840761/chr20:33176411)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BMP7 P18075	.
FUNCTION: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Promotes brown adipocyte differentiation by P38 MAPK pathway-mediated activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061). {ECO:0000269\|PubMed:27923061}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PIGU

chr20:55840761

chr20:33176411

ENST00000374820

269_289

189

416.0

Region

Note=May be involved in recognition of long-chain fatty acids in GPI

Tgene

PIGU

chr20:55840761

chr20:33176411

ENST00000374820

188_208

189

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:55840761

chr20:33176411

ENST00000374820

237_257

189

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:55840761

chr20:33176411

ENST00000374820

259_279

189

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:55840761

chr20:33176411

ENST00000374820

286_306

189

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:55840761

chr20:33176411

ENST00000374820

313_333

189

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:55840761

chr20:33176411

ENST00000374820

355_375

189

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:55840761

chr20:33176411

ENST00000374820

386_406

189

416.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PIGU

chr20:55840761

chr20:33176411

ENST00000374820

166_186

189

416.0

Transmembrane

Helical

Tgene

PIGU

chr20:55840761

chr20:33176411

ENST00000374820

66_86

189

416.0

Transmembrane

Helical

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Fusion Gene Sequence for BMP7-PIGU

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>9885_9885_1_BMP7-PIGU_BMP7_chr20_55840761_ENST00000395863_PIGU_chr20_33176411_ENST00000374820_length(transcript)=1928nt_BP=924nt
CGAGGCGGCCTCTTGTGCGATCCAGGGCGCACAAGGCTGGGAGAGCGCCCCGGGGCCCCTGCTATCCGCGCCGGAGGTTGGAAGAGGGTG
GGTTGCCGCCGCCCGAGGGCGAGAGCGCCAGAGGAGCGGGAAGAAGGAGCGCTCGCCCGCCCGCCTGCCTCCTCGCTGCCTCCCCGGCGT
TGGCTCTCTGGACTCCTAGGCTTGCTGGCTGCTCCTCCCACCCGCGCCCGCCTCCTCACTCGCCTTTTCGTTCGCCGGGGCTGCTTTCCA
AGCCCTGCGGTGCGCCCGGGCGAGTGCGGGGCGAGGGGCCCGGGGCCAGCACCGAGCAGGGGGCGGGGGTCCGGGCAGAGCGCGGCCGGC
CGGGGAGGGGCCATGTCTGGCGCGGGCGCAGCGGGGCCCGTCTGCAGCAAGTGACCGAGCGGCGCGGACGGCCGCCTGCCCCCTCTGCCA
CCTGGGGCGGTGCGGGCCCGGAGCCCGGAGCCCGGGTAGCGCGTAGAGCCGGCGCGATGCACGTGCGCTCACTGCGAGCTGCGGCGCCGC
ACAGCTTCGTGGCGCTCTGGGCACCCCTGTTCCTGCTGCGCTCCGCCCTGGCCGACTTCAGCCTGGACAACGAGGTGCACTCGAGCTTCA
TCCACCGGCGCCTCCGCAGCCAGGAGCGGCGGGAGATGCAGCGCGAGATCCTCTCCATTTTGGGCTTGCCCCACCGCCCGCGCCCGCACC
TCCAGGGCAAGCACAACTCGGCACCCATGTTCATGCTGGACCTGTACAACGCCATGGCGGTGGAGGAGGGCGGCGGGCCCGGCGGCCAGG
GCTTCTCCTACCCCTACAAGGCCGTCTTCAGTACCCAGGGCCCCCCTCTGGCCAGCCTGCAAGATAGCCATTTCCTCACCGACGCCGACA
TGGTCATGAGCTTCGTCAACCTCGCGGCAGTACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCATG
ATGTATGTGGGAAGCCTAGTGGTAATCATTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTATA
CTTTCTGTTCCAGATCTCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATGT
GTGTTTCAGATCAACGTCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGCT
GTCATCGCCATCTTTAAGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCGTGTGGAACCATCTCTACAGATTC
CTGAGAAACATCTTTGTCCTCACCTGCATCATCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAGT
GCCAACTCTAATTTCTTTTATGCCATCACACTGACCTTCAACGTTGGGCAGATCCTGCTCATCTCTGATTACTTCTATGCCTTCCTGCGG
CGGGAGTACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCACAGAGGCCATGCTCGTGCTCAAGTAGGCCTGGCTGGCACAG
GGCTGCATGGACCTCAGGGGGCTGTGGGGCCAGAAGCTGGGCCAAGCCCTCCAGCCAGAGTTGCCAGCAGGCGAGTGCTTGGGCAGAAGA
GGTTCGAGTCCAGGGTCACAAGTCTCTGGTACCAAAAGGGACCCATGGCTGACTGACAGCAAGGCCTATGGGGAAGAACTGGGAGCTCCC
CAACTTGGACCCCCACCTTGTGGCTCTGCACACCAAGGAGCCCCCTCCCAGACAGGAAGGAGAAGAGGCAGGTGAGCAGGGCTTGTTAGA

>9885_9885_1_BMP7-PIGU_BMP7_chr20_55840761_ENST00000395863_PIGU_chr20_33176411_ENST00000374820_length(amino acids)=355AA_BP=282
MEEGGLPPPEGESARGAGRRSARPPACLLAASPALALWTPRLAGCSSHPRPPPHSPFRSPGLLSKPCGAPGRVRGEGPGASTEQGAGVRA
ERGRPGRGHVWRGRSGARLQQVTERRGRPPAPSATWGGAGPEPGARVARRAGAMHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEV
HSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFL

--------------------------------------------------------------
>9885_9885_2_BMP7-PIGU_BMP7_chr20_55840761_ENST00000395863_PIGU_chr20_33176411_ENST00000452740_length(transcript)=1766nt_BP=924nt
CGAGGCGGCCTCTTGTGCGATCCAGGGCGCACAAGGCTGGGAGAGCGCCCCGGGGCCCCTGCTATCCGCGCCGGAGGTTGGAAGAGGGTG
GGTTGCCGCCGCCCGAGGGCGAGAGCGCCAGAGGAGCGGGAAGAAGGAGCGCTCGCCCGCCCGCCTGCCTCCTCGCTGCCTCCCCGGCGT
TGGCTCTCTGGACTCCTAGGCTTGCTGGCTGCTCCTCCCACCCGCGCCCGCCTCCTCACTCGCCTTTTCGTTCGCCGGGGCTGCTTTCCA
AGCCCTGCGGTGCGCCCGGGCGAGTGCGGGGCGAGGGGCCCGGGGCCAGCACCGAGCAGGGGGCGGGGGTCCGGGCAGAGCGCGGCCGGC
CGGGGAGGGGCCATGTCTGGCGCGGGCGCAGCGGGGCCCGTCTGCAGCAAGTGACCGAGCGGCGCGGACGGCCGCCTGCCCCCTCTGCCA
CCTGGGGCGGTGCGGGCCCGGAGCCCGGAGCCCGGGTAGCGCGTAGAGCCGGCGCGATGCACGTGCGCTCACTGCGAGCTGCGGCGCCGC
ACAGCTTCGTGGCGCTCTGGGCACCCCTGTTCCTGCTGCGCTCCGCCCTGGCCGACTTCAGCCTGGACAACGAGGTGCACTCGAGCTTCA
TCCACCGGCGCCTCCGCAGCCAGGAGCGGCGGGAGATGCAGCGCGAGATCCTCTCCATTTTGGGCTTGCCCCACCGCCCGCGCCCGCACC
TCCAGGGCAAGCACAACTCGGCACCCATGTTCATGCTGGACCTGTACAACGCCATGGCGGTGGAGGAGGGCGGCGGGCCCGGCGGCCAGG
GCTTCTCCTACCCCTACAAGGCCGTCTTCAGTACCCAGGGCCCCCCTCTGGCCAGCCTGCAAGATAGCCATTTCCTCACCGACGCCGACA
TGGTCATGAGCTTCGTCAACCTCGCGGCAGTACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCATG
ATGTATGTGGGAAGCCTAGTGGTAATCATTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTATA
CTTTCTGTTCCAGATCTCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATGT
GTGTTTCAGATCAACGTCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGCT
GTCATCGCCATCTTTAAGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCGTGTGGAACCATCTCTACAGATTC
CTGAGAAACATCTTTGTCCTCACCTGCATCATCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAGT
GCCAACTCTAATTTCTTTTATGCCATCACACTGACCTTCAACGTTGGGCAGATGGGCTTCTGTGGTGATAGAATGGCAGGTACTTGTCCT
GAGGCCATCAGAGCTGCTGGTGACAGGACACCTTCCTGAACTCCTCCAGGCGCCTCTGATCTCTCCTTAGCTGCTGTTGTGTTACCTTCA
GATCCTGCTCATCTCTGATTACTTCTATGCCTTCCTGCGGCGGGAGTACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCAC

>9885_9885_2_BMP7-PIGU_BMP7_chr20_55840761_ENST00000395863_PIGU_chr20_33176411_ENST00000452740_length(amino acids)=355AA_BP=282
MEEGGLPPPEGESARGAGRRSARPPACLLAASPALALWTPRLAGCSSHPRPPPHSPFRSPGLLSKPCGAPGRVRGEGPGASTEQGAGVRA
ERGRPGRGHVWRGRSGARLQQVTERRGRPPAPSATWGGAGPEPGARVARRAGAMHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEV
HSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFL

--------------------------------------------------------------
>9885_9885_3_BMP7-PIGU_BMP7_chr20_55840761_ENST00000395864_PIGU_chr20_33176411_ENST00000374820_length(transcript)=1642nt_BP=638nt
CGGGCGAGTGCGGGGCGAGGGGCCCGGGGCCAGCACCGAGCAGGGGGCGGGGGTCCGGGCAGAGCGCGGCCGGCCGGGGAGGGGCCATGT
CTGGCGCGGGCGCAGCGGGGCCCGTCTGCAGCAAGTGACCGAGCGGCGCGGACGGCCGCCTGCCCCCTCTGCCACCTGGGGCGGTGCGGG
CCCGGAGCCCGGAGCCCGGGTAGCGCGTAGAGCCGGCGCGATGCACGTGCGCTCACTGCGAGCTGCGGCGCCGCACAGCTTCGTGGCGCT
CTGGGCACCCCTGTTCCTGCTGCGCTCCGCCCTGGCCGACTTCAGCCTGGACAACGAGGTGCACTCGAGCTTCATCCACCGGCGCCTCCG
CAGCCAGGAGCGGCGGGAGATGCAGCGCGAGATCCTCTCCATTTTGGGCTTGCCCCACCGCCCGCGCCCGCACCTCCAGGGCAAGCACAA
CTCGGCACCCATGTTCATGCTGGACCTGTACAACGCCATGGCGGTGGAGGAGGGCGGCGGGCCCGGCGGCCAGGGCTTCTCCTACCCCTA
CAAGGCCGTCTTCAGTACCCAGGGCCCCCCTCTGGCCAGCCTGCAAGATAGCCATTTCCTCACCGACGCCGACATGGTCATGAGCTTCGT
CAACCTCGCGGCAGTACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCATGATGTATGTGGGAAGCC
TAGTGGTAATCATTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTATACTTTCTGTTCCAGATC
TCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATGTGTGTTTCAGATCAACG
TCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGCTGTCATCGCCATCTTTA
AGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCGTGTGGAACCATCTCTACAGATTCCTGAGAAACATCTTTG
TCCTCACCTGCATCATCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAGTGCCAACTCTAATTTCT
TTTATGCCATCACACTGACCTTCAACGTTGGGCAGATCCTGCTCATCTCTGATTACTTCTATGCCTTCCTGCGGCGGGAGTACTACCTCA
CACATGGCCTCTACTTGACCGCCAAGGATGGCACAGAGGCCATGCTCGTGCTCAAGTAGGCCTGGCTGGCACAGGGCTGCATGGACCTCA
GGGGGCTGTGGGGCCAGAAGCTGGGCCAAGCCCTCCAGCCAGAGTTGCCAGCAGGCGAGTGCTTGGGCAGAAGAGGTTCGAGTCCAGGGT
CACAAGTCTCTGGTACCAAAAGGGACCCATGGCTGACTGACAGCAAGGCCTATGGGGAAGAACTGGGAGCTCCCCAACTTGGACCCCCAC
CTTGTGGCTCTGCACACCAAGGAGCCCCCTCCCAGACAGGAAGGAGAAGAGGCAGGTGAGCAGGGCTTGTTAGATTGTGGCTACTTAATA

>9885_9885_3_BMP7-PIGU_BMP7_chr20_55840761_ENST00000395864_PIGU_chr20_33176411_ENST00000374820_length(amino acids)=247AA_BP=174
MQQVTERRGRPPAPSATWGGAGPEPGARVARRAGAMHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQ
REILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLAAVHTC

--------------------------------------------------------------
>9885_9885_4_BMP7-PIGU_BMP7_chr20_55840761_ENST00000395864_PIGU_chr20_33176411_ENST00000452740_length(transcript)=1480nt_BP=638nt
CGGGCGAGTGCGGGGCGAGGGGCCCGGGGCCAGCACCGAGCAGGGGGCGGGGGTCCGGGCAGAGCGCGGCCGGCCGGGGAGGGGCCATGT
CTGGCGCGGGCGCAGCGGGGCCCGTCTGCAGCAAGTGACCGAGCGGCGCGGACGGCCGCCTGCCCCCTCTGCCACCTGGGGCGGTGCGGG
CCCGGAGCCCGGAGCCCGGGTAGCGCGTAGAGCCGGCGCGATGCACGTGCGCTCACTGCGAGCTGCGGCGCCGCACAGCTTCGTGGCGCT
CTGGGCACCCCTGTTCCTGCTGCGCTCCGCCCTGGCCGACTTCAGCCTGGACAACGAGGTGCACTCGAGCTTCATCCACCGGCGCCTCCG
CAGCCAGGAGCGGCGGGAGATGCAGCGCGAGATCCTCTCCATTTTGGGCTTGCCCCACCGCCCGCGCCCGCACCTCCAGGGCAAGCACAA
CTCGGCACCCATGTTCATGCTGGACCTGTACAACGCCATGGCGGTGGAGGAGGGCGGCGGGCCCGGCGGCCAGGGCTTCTCCTACCCCTA
CAAGGCCGTCTTCAGTACCCAGGGCCCCCCTCTGGCCAGCCTGCAAGATAGCCATTTCCTCACCGACGCCGACATGGTCATGAGCTTCGT
CAACCTCGCGGCAGTACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCATGATGTATGTGGGAAGCC
TAGTGGTAATCATTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTATACTTTCTGTTCCAGATC
TCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATGTGTGTTTCAGATCAACG
TCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGCTGTCATCGCCATCTTTA
AGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCGTGTGGAACCATCTCTACAGATTCCTGAGAAACATCTTTG
TCCTCACCTGCATCATCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAGTGCCAACTCTAATTTCT
TTTATGCCATCACACTGACCTTCAACGTTGGGCAGATGGGCTTCTGTGGTGATAGAATGGCAGGTACTTGTCCTGAGGCCATCAGAGCTG
CTGGTGACAGGACACCTTCCTGAACTCCTCCAGGCGCCTCTGATCTCTCCTTAGCTGCTGTTGTGTTACCTTCAGATCCTGCTCATCTCT
GATTACTTCTATGCCTTCCTGCGGCGGGAGTACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCACAGAGGCCATGCTCGTG

>9885_9885_4_BMP7-PIGU_BMP7_chr20_55840761_ENST00000395864_PIGU_chr20_33176411_ENST00000452740_length(amino acids)=247AA_BP=174
MQQVTERRGRPPAPSATWGGAGPEPGARVARRAGAMHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQ
REILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLAAVHTC

--------------------------------------------------------------
>9885_9885_5_BMP7-PIGU_BMP7_chr20_55840761_ENST00000450594_PIGU_chr20_33176411_ENST00000374820_length(transcript)=1929nt_BP=925nt
CCGAGGCGGCCTCTTGTGCGATCCAGGGCGCACAAGGCTGGGAGAGCGCCCCGGGGCCCCTGCTATCCGCGCCGGAGGTTGGAAGAGGGT
GGGTTGCCGCCGCCCGAGGGCGAGAGCGCCAGAGGAGCGGGAAGAAGGAGCGCTCGCCCGCCCGCCTGCCTCCTCGCTGCCTCCCCGGCG
TTGGCTCTCTGGACTCCTAGGCTTGCTGGCTGCTCCTCCCACCCGCGCCCGCCTCCTCACTCGCCTTTTCGTTCGCCGGGGCTGCTTTCC
AAGCCCTGCGGTGCGCCCGGGCGAGTGCGGGGCGAGGGGCCCGGGGCCAGCACCGAGCAGGGGGCGGGGGTCCGGGCAGAGCGCGGCCGG
CCGGGGAGGGGCCATGTCTGGCGCGGGCGCAGCGGGGCCCGTCTGCAGCAAGTGACCGAGCGGCGCGGACGGCCGCCTGCCCCCTCTGCC
ACCTGGGGCGGTGCGGGCCCGGAGCCCGGAGCCCGGGTAGCGCGTAGAGCCGGCGCGATGCACGTGCGCTCACTGCGAGCTGCGGCGCCG
CACAGCTTCGTGGCGCTCTGGGCACCCCTGTTCCTGCTGCGCTCCGCCCTGGCCGACTTCAGCCTGGACAACGAGGTGCACTCGAGCTTC
ATCCACCGGCGCCTCCGCAGCCAGGAGCGGCGGGAGATGCAGCGCGAGATCCTCTCCATTTTGGGCTTGCCCCACCGCCCGCGCCCGCAC
CTCCAGGGCAAGCACAACTCGGCACCCATGTTCATGCTGGACCTGTACAACGCCATGGCGGTGGAGGAGGGCGGCGGGCCCGGCGGCCAG
GGCTTCTCCTACCCCTACAAGGCCGTCTTCAGTACCCAGGGCCCCCCTCTGGCCAGCCTGCAAGATAGCCATTTCCTCACCGACGCCGAC
ATGGTCATGAGCTTCGTCAACCTCGCGGCAGTACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCAT
GATGTATGTGGGAAGCCTAGTGGTAATCATTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTAT
ACTTTCTGTTCCAGATCTCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATG
TGTGTTTCAGATCAACGTCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGC
TGTCATCGCCATCTTTAAGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCGTGTGGAACCATCTCTACAGATT
CCTGAGAAACATCTTTGTCCTCACCTGCATCATCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAG
TGCCAACTCTAATTTCTTTTATGCCATCACACTGACCTTCAACGTTGGGCAGATCCTGCTCATCTCTGATTACTTCTATGCCTTCCTGCG
GCGGGAGTACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCACAGAGGCCATGCTCGTGCTCAAGTAGGCCTGGCTGGCACA
GGGCTGCATGGACCTCAGGGGGCTGTGGGGCCAGAAGCTGGGCCAAGCCCTCCAGCCAGAGTTGCCAGCAGGCGAGTGCTTGGGCAGAAG
AGGTTCGAGTCCAGGGTCACAAGTCTCTGGTACCAAAAGGGACCCATGGCTGACTGACAGCAAGGCCTATGGGGAAGAACTGGGAGCTCC
CCAACTTGGACCCCCACCTTGTGGCTCTGCACACCAAGGAGCCCCCTCCCAGACAGGAAGGAGAAGAGGCAGGTGAGCAGGGCTTGTTAG

>9885_9885_5_BMP7-PIGU_BMP7_chr20_55840761_ENST00000450594_PIGU_chr20_33176411_ENST00000374820_length(amino acids)=355AA_BP=282
MEEGGLPPPEGESARGAGRRSARPPACLLAASPALALWTPRLAGCSSHPRPPPHSPFRSPGLLSKPCGAPGRVRGEGPGASTEQGAGVRA
ERGRPGRGHVWRGRSGARLQQVTERRGRPPAPSATWGGAGPEPGARVARRAGAMHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEV
HSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFL

--------------------------------------------------------------
>9885_9885_6_BMP7-PIGU_BMP7_chr20_55840761_ENST00000450594_PIGU_chr20_33176411_ENST00000452740_length(transcript)=1767nt_BP=925nt
CCGAGGCGGCCTCTTGTGCGATCCAGGGCGCACAAGGCTGGGAGAGCGCCCCGGGGCCCCTGCTATCCGCGCCGGAGGTTGGAAGAGGGT
GGGTTGCCGCCGCCCGAGGGCGAGAGCGCCAGAGGAGCGGGAAGAAGGAGCGCTCGCCCGCCCGCCTGCCTCCTCGCTGCCTCCCCGGCG
TTGGCTCTCTGGACTCCTAGGCTTGCTGGCTGCTCCTCCCACCCGCGCCCGCCTCCTCACTCGCCTTTTCGTTCGCCGGGGCTGCTTTCC
AAGCCCTGCGGTGCGCCCGGGCGAGTGCGGGGCGAGGGGCCCGGGGCCAGCACCGAGCAGGGGGCGGGGGTCCGGGCAGAGCGCGGCCGG
CCGGGGAGGGGCCATGTCTGGCGCGGGCGCAGCGGGGCCCGTCTGCAGCAAGTGACCGAGCGGCGCGGACGGCCGCCTGCCCCCTCTGCC
ACCTGGGGCGGTGCGGGCCCGGAGCCCGGAGCCCGGGTAGCGCGTAGAGCCGGCGCGATGCACGTGCGCTCACTGCGAGCTGCGGCGCCG
CACAGCTTCGTGGCGCTCTGGGCACCCCTGTTCCTGCTGCGCTCCGCCCTGGCCGACTTCAGCCTGGACAACGAGGTGCACTCGAGCTTC
ATCCACCGGCGCCTCCGCAGCCAGGAGCGGCGGGAGATGCAGCGCGAGATCCTCTCCATTTTGGGCTTGCCCCACCGCCCGCGCCCGCAC
CTCCAGGGCAAGCACAACTCGGCACCCATGTTCATGCTGGACCTGTACAACGCCATGGCGGTGGAGGAGGGCGGCGGGCCCGGCGGCCAG
GGCTTCTCCTACCCCTACAAGGCCGTCTTCAGTACCCAGGGCCCCCCTCTGGCCAGCCTGCAAGATAGCCATTTCCTCACCGACGCCGAC
ATGGTCATGAGCTTCGTCAACCTCGCGGCAGTACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCAT
GATGTATGTGGGAAGCCTAGTGGTAATCATTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTAT
ACTTTCTGTTCCAGATCTCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATG
TGTGTTTCAGATCAACGTCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGC
TGTCATCGCCATCTTTAAGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCGTGTGGAACCATCTCTACAGATT
CCTGAGAAACATCTTTGTCCTCACCTGCATCATCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAG
TGCCAACTCTAATTTCTTTTATGCCATCACACTGACCTTCAACGTTGGGCAGATGGGCTTCTGTGGTGATAGAATGGCAGGTACTTGTCC
TGAGGCCATCAGAGCTGCTGGTGACAGGACACCTTCCTGAACTCCTCCAGGCGCCTCTGATCTCTCCTTAGCTGCTGTTGTGTTACCTTC
AGATCCTGCTCATCTCTGATTACTTCTATGCCTTCCTGCGGCGGGAGTACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCA

>9885_9885_6_BMP7-PIGU_BMP7_chr20_55840761_ENST00000450594_PIGU_chr20_33176411_ENST00000452740_length(amino acids)=355AA_BP=282
MEEGGLPPPEGESARGAGRRSARPPACLLAASPALALWTPRLAGCSSHPRPPPHSPFRSPGLLSKPCGAPGRVRGEGPGASTEQGAGVRA
ERGRPGRGHVWRGRSGARLQQVTERRGRPPAPSATWGGAGPEPGARVARRAGAMHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEV
HSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BMP7-PIGU

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BMP7-PIGU

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BMP7-PIGU

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source