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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WDR12-PARD3B (FusionGDB2 ID:98875)

Fusion Gene Summary for WDR12-PARD3B

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR12-PARD3B
Fusion gene ID: 98875
HgeneTgene
Gene symbol

WDR12

PARD3B

Gene ID

55759

117583

Gene nameWD repeat domain 12par-3 family cell polarity regulator beta
SynonymsYTM1ALS2CR19|PAR3B|PAR3L|PAR3beta
Cytomap

2q33.2

2q33.3

Type of geneprotein-codingprotein-coding
Descriptionribosome biogenesis protein WDR12WD repeat-containing protein 12partitioning defective 3 homolog BPAR3-L proteinamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 19amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 proteinpar-3 partitioning defective 3 homolog Bpartitioning
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261015, ENST00000477723, 
ENST00000488622, ENST00000349953, 
ENST00000351153, ENST00000358768, 
ENST00000462231, ENST00000406610, 
Fusion gene scores* DoF score4 X 4 X 2=3217 X 20 X 10=3400
# samples 423
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(23/3400*10)=-3.88582898008069
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR12 [Title/Abstract] AND PARD3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDR12(203776159)-PARD3B(206418048), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across WDR12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PARD3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-7539-01AWDR12chr2

203776159

-PARD3Bchr2

206418048

+


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Fusion Gene ORF analysis for WDR12-PARD3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000261015ENST00000488622WDR12chr2

203776159

-PARD3Bchr2

206418048

+
5CDS-intronENST00000261015ENST00000349953WDR12chr2

203776159

-PARD3Bchr2

206418048

+
5CDS-intronENST00000261015ENST00000351153WDR12chr2

203776159

-PARD3Bchr2

206418048

+
5CDS-intronENST00000261015ENST00000358768WDR12chr2

203776159

-PARD3Bchr2

206418048

+
5CDS-intronENST00000261015ENST00000462231WDR12chr2

203776159

-PARD3Bchr2

206418048

+
In-frameENST00000261015ENST00000406610WDR12chr2

203776159

-PARD3Bchr2

206418048

+
intron-3CDSENST00000477723ENST00000406610WDR12chr2

203776159

-PARD3Bchr2

206418048

+
intron-3UTRENST00000477723ENST00000488622WDR12chr2

203776159

-PARD3Bchr2

206418048

+
intron-intronENST00000477723ENST00000349953WDR12chr2

203776159

-PARD3Bchr2

206418048

+
intron-intronENST00000477723ENST00000351153WDR12chr2

203776159

-PARD3Bchr2

206418048

+
intron-intronENST00000477723ENST00000358768WDR12chr2

203776159

-PARD3Bchr2

206418048

+
intron-intronENST00000477723ENST00000462231WDR12chr2

203776159

-PARD3Bchr2

206418048

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261015WDR12chr2203776159-ENST00000406610PARD3Bchr2206418048+55787911258863131

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261015ENST00000406610WDR12chr2203776159-PARD3Bchr2206418048+0.0057685130.99423146

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Fusion Genomic Features for WDR12-PARD3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WDR12chr2203776158-PARD3Bchr2206418047+4.39E-060.9999956
WDR12chr2203776158-PARD3Bchr2206418047+4.39E-060.9999956

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for WDR12-PARD3B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:203776159/chr2:206418048)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePARD3Bchr2:203776159chr2:206418048ENST0000034995319221144_11499591105.0Compositional biasNote=Poly-Pro
TgenePARD3Bchr2:203776159chr2:206418048ENST0000035876819221144_11499981144.0Compositional biasNote=Poly-Pro
TgenePARD3Bchr2:203776159chr2:206418048ENST0000040661020231144_114910601206.0Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR12chr2:203776159chr2:206418048ENST00000261015-1134_8713424.0RegionUbiquitin-like (UBL) domain
HgeneWDR12chr2:203776159chr2:206418048ENST00000261015-11398_42313424.0RegionNote=Sufficient for nucleolar localization
HgeneWDR12chr2:203776159chr2:206418048ENST00000261015-113138_18013424.0RepeatNote=WD 2
HgeneWDR12chr2:203776159chr2:206418048ENST00000261015-113187_22613424.0RepeatNote=WD 3
HgeneWDR12chr2:203776159chr2:206418048ENST00000261015-113255_29313424.0RepeatNote=WD 4
HgeneWDR12chr2:203776159chr2:206418048ENST00000261015-113295_33413424.0RepeatNote=WD 5
HgeneWDR12chr2:203776159chr2:206418048ENST00000261015-113340_38013424.0RepeatNote=WD 6
HgeneWDR12chr2:203776159chr2:206418048ENST00000261015-113384_42213424.0RepeatNote=WD 7
HgeneWDR12chr2:203776159chr2:206418048ENST00000261015-11399_13713424.0RepeatNote=WD 1
TgenePARD3Bchr2:203776159chr2:206418048ENST000003499531922830_8969591105.0Compositional biasNote=Lys-rich
TgenePARD3Bchr2:203776159chr2:206418048ENST000003587681922830_8969981144.0Compositional biasNote=Lys-rich
TgenePARD3Bchr2:203776159chr2:206418048ENST000004066102023830_89610601206.0Compositional biasNote=Lys-rich
TgenePARD3Bchr2:203776159chr2:206418048ENST000003499531922201_2899591105.0DomainPDZ 1
TgenePARD3Bchr2:203776159chr2:206418048ENST000003499531922383_4689591105.0DomainPDZ 2
TgenePARD3Bchr2:203776159chr2:206418048ENST000003499531922498_5859591105.0DomainPDZ 3
TgenePARD3Bchr2:203776159chr2:206418048ENST000003587681922201_2899981144.0DomainPDZ 1
TgenePARD3Bchr2:203776159chr2:206418048ENST000003587681922383_4689981144.0DomainPDZ 2
TgenePARD3Bchr2:203776159chr2:206418048ENST000003587681922498_5859981144.0DomainPDZ 3
TgenePARD3Bchr2:203776159chr2:206418048ENST000004066102023201_28910601206.0DomainPDZ 1
TgenePARD3Bchr2:203776159chr2:206418048ENST000004066102023383_46810601206.0DomainPDZ 2
TgenePARD3Bchr2:203776159chr2:206418048ENST000004066102023498_58510601206.0DomainPDZ 3


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Fusion Gene Sequence for WDR12-PARD3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98875_98875_1_WDR12-PARD3B_WDR12_chr2_203776159_ENST00000261015_PARD3B_chr2_206418048_ENST00000406610_length(transcript)=5578nt_BP=791nt
ATCGGCCACCGTCGACCGTTTCCTCTCTCATCCGTTCTTTTCTTTGTATTTCCGCCTCTCGCCTCTCTCTAAAAGCCGCAGTTAGAGGCG
AGATTTAGGAAAAACCTCTGCCGAGTGAGCCTCTGGTTGGGAATATGTATGAGAAAAAAAAACTGGCAAGGCGTTAGTCAAGCAAAGCTG
AAGGCAGAGGAAATTTGATATCTGGCTGGAGTCTAGAGGATTTAATGCAAATAAGATACTCTGAGGGCAGCGTGGCAAAAAAAGACTACA
ATTCCCGGTGGTCACAGCGTTTGAGAAGCGATGCTTTCTGAGACTTGTAGTAACTAGGAGCTGTGTTTGAACTATCCAGGCTCAGGACAG
CCTCTTGAAAAAAAATTTTTTATTAATAAAGCGGATTTGAGTGGGATCTTTTTCCTAATCGATTACGGGCCCACACGTATGGGAAGAATT
CTAACAATGATTAAAGGGACATGCTACCTTTACGACTATCCTTTTCTAATCGATGACTCCTAAATCTAGGAGTAGGTAGTCGATGTTTGT
GGTCTGGGCGTCTGTAGAAGGGCAACCTCGTGCTTTCTGCAGAGGAGACCGGAGGGCAGAAGGCAGAGTCCAGGCTTAGACTGCAGTTCC
TCGCTTACCTGTGCAGTCTAATTTTGAGCTGCCTCTTTGTAGTCTTAAAAGGCAGGAGCTTCGTGTTGTGGGTCTGCTAACCCGTACGTT
TCCGTGGGCAAGTCGTGTGTACTCCTCGCCATGGCTCAGCTCCAAACACGCTTCTACACTGATAACAAGAAGTGCCTGGAAGGGGTCCAG
ATGGGAATGCACACAACCTCCGCTTTGAAGGGATGGAGAGGCAGTACGCATCCTTACCCAGGGGAGGACCCGCAGATCCTGTAGACTATC
TGCCAGCAGCACCTCGGGGGCTCTACAAGGAAAGGGAGCTTCCCTATTATCCAGGGGCTCATCCTATGCACCCTCCCAAAGGGAGCTATC
CCCGCCCCACAGAGCTCAGGGTGGCAGATCTCCGGTATCCTCAGCACTACCCACCCCCGCCAGCTCCCCAGCACAAAGGACCCTTTCGAC
AAGACGTTCCGCCTTCCCCTCCCCAGCACCAAAGAATGCCAGCCTATCAGGAAACAGGCAGACCAGGGCCCCGTGGGGGCAGCCCAGACC
AGTACCCTTACCGAACCCAGGATTCCCGGCAGAAGAACCCCATGACTGCAGCCGTATAGCTGAGTGCCACCGAGGCCAGCCCGGTCCAGA
AAGGAAGGTGTCTACTCTACCTTTGCCCTTTCTAAACCTGAAGACCTCCTTGGTGTTAGGAATTCTCCATGTTACTGATAAGCTTTTTCT
CACTGACATTGTAACGCATGACTGCTAATCAGAGAGAAAAAGAAGGGGAAGGGAATTGGGGAGGAAAAAAAATCAGAAGGAAGACGAAAG
ATGGGGCTATAAAAACAAAACTACCTGATAGTTGAAACGCTTTCAGAGTTGTTCAAATCAGTGAGAGTGGCAACGGAACACACAAACAAC
TAATTATGGAACTCTACTCTGGGGATCCTCTCTGGCTAGATAACCTGTGCTGATGTGCAGACACGTGGACATCCCCCTCTGAGACTGGCG
GTCCAGAGGCAGTCTCTGCCAGGCAGCATTACCCGCTCCGAGGTGGAGCCTCAGCCCCCTTCTTAGAGCTGTTAAGTCTAAGGTGTGGCA
GAGCAGACAGAGATAGAGGCATCTGAAGTGAGTATAGGTTTTTTGACTAAGAAAAAAAACAACAGCAAACATGACTAGTGATCTTGAAAT
ATTTTGTACCGAGAGAAAGACTGCATTTATTTGTAGAATTTATCAGGTTTCTGATACCACTCATTGGATGTAAACATTTCATGTTTCCTC
ACTTTTGATATGAAAGTCGGTAAAATGCAGTATTAGTCCCGGGAGGATGTGCACAGCTGGTCAGAGCTTCCAGAAGGAATATCTTCCGAG
GACTAAGGTGATCAGGTTAAGAGGGTTCAACATCCCACGGCCCTCACCTTCCTCCCTCCCACATTCCAGGCATGGAGATATCTGGTTTCA
GAGTCAGCCCCAAATCTCCTGCCTATAATTACTTTAACTGGGGTCTCTAAGGTTCCCACTTGAGGGCTAAAATGTAGTTGGGAAAGAGGG
CCTACTGGGGAGGTCTCACAGGAGGCAGTGCCCTGGGAAATGCCAAGTCCAGACTCAGTGCCAAGCAGTAACCATCTGCACTCGGGGACA
GCGAGGAGCTGACCATGGCCTCTGATGACCAGCAGGTATTAGATGGAAGTGAATGAGAGAGAGAGAGAGAGAGAGTATGTGTGTGTGTGT
GTATGTGTGTGTTCGAACACATATGATTGCCAGTATGGAGAATGAAAGATTAATAATGCTTTCTGGAGAGTTTGATGCAAAAGTGGGGGA
AACGGAGAAAAGGCGCTAAGGCTAAATCCATCTGCATTTGCTATATTTCATTAGCTAAAGTCAGGTCAGGGCAGGGCCAAGGCCTCCAAT
TGGCAAAGGACAGTGTTATGGCTTTAAAAAGCTGAAACCCCAACCTCTAAGTAGATCACAATGTTTTCTGAGCTTTGCAGTAATTTTCTA
TGGAAACTAAAACCTCTAAAACATACAAGCTGGCCCAAATGAGAACACAAGCAAAAGATGTGGAAGACAGCAAAACCTGAGCACTGGTTT
GAACCAGGCACTGACATTTGAAATGCTTTAAGCCTTTTCACATTCCTTCTTTATTCCCTCCAAAAAAAAAAGTCTTGAGTTTAATTTAGG
TCTATTTTGGCTGAGATTAGCATACCTCTGACTCACAGGATTTAATAAATTATAGTATTATTGAATACATAGGACATCCCTCTACCCCAG
CTTACTCTTATCTTTTTAATTTAAAATAGTATTCTGCTACCAAGAAGGATGCAACTGCTAGTTTTAGATGTAAATAGTGTTATTTACTGG
ACTTTGTGATATTATTTTCTTAACTACACTTTACTATGGCCCTGTTGAAAACAGACTATCAAGTTTTTTGTCTCTGTTCTGTCATCTCTC
TTAAGCCAGGCACCTTTAGAGTGTTTGCAATTTGTTCGAAGTGGTTGAGGATCTCAGGCCCTGCTCACGTGAGGTGGAGTGCAGGGGAGC
TACCGGTTTCCCTGCTGACCTGCTGAATGCTACCTTCCCCTCGAGTTGAATACACCTTAAGGAAAATGATAACACGAGGGACGTGTAACT
TGTTTTGAAGCATTAAAAACCAGCAGCTCTTCACTATGTTCCATATTTTAACCAAACTACTGTAGACTACTAAACATAGCCAAGCCAGAA
CATTCCTTCTGGATTAAGCCTAGGCCACTTGAGGGGCAGCCAGGGGTGATGGTGTCAGGTGAGAATCCTGTGTCTTGAAGGAGTGGCCTT
TACAGGAAGAGTGCCCATGTTTTCACCTGCAGCGTTGCCACCAGAGTGTGCAATACCTCCTGCACACAGGCTCAGGGTAAACTGCTCCAA
AGCTGGGTTTTGTGTTGCATACAAAGTCAATAAAATAGTTGCTAATCCTGAATGGCAGCCAGTGATGTGAAGGTACTATTAAAGTGAACA
AAAACTAGATTGCAACAGTTTTCTTTCCTTGCTTGAAGTATAACACACGCTCCATTTGATCCTGCCTGAAAGAAGCTAACATTATATTTG
TGACAGACAGAGGCTCCATCAAGCCAAGCAACAATTAACAGCTCAAGTGTAAGATTTATAAATGCCCGTGTACTCACCCTTCAATTGTTA
CCACCCAGAGGTTACAGGACTCTTTCCCAGCATTTAGGGGAACAGGCTTTTAGAGTATTTAGAAGACCAGGCTATAATCAGTAATGTGCC
TGGGAGCAGGAAATAGCTCCCAATTTATTTATGGCCTTGGGAAAACTCAATCCGGTGTCTCCTTGTAGCTCAGAACACTAATAGCCCCCC
TGGAAGAGAGTGGCACATTGAGCTCCAAACCCAATCAACATACATCCACTTGGCTGCAGATCTGACTGCTGGGTCATGAAGGCCGTGAAA
TGATGTTTGCCCTCAAGTCACTAGATATTTTAAGAAGCCCTATTTTTCTCCCTTTTTGCAGGAGTAGAGAGATGAAAGAGGACAGACCAT
TGAAAACTTTTAGATGCAGGAGAATTGAGACTTCCACAAGGGAGAGAAACACAGCCTCCCCAGAATCCATTATGCCATCGGGTTGTGGCA
CTCTCACCCTTGCCATAATACCGTTTCCTAACAATATCAAATCAGTGGATGAAATACAAGCTCAGAAACAGGAACATTTTCCTAAATCAT
AACCTAATAGCAAACAAAAATTGAAAAAACAATTATTCTGAAGCTCATTATTCTTAGATCTGTAGATATATATGTGTTGACTCCCACAGG
ATGGCACCAAGTAAAGATCTTAAGAGCATAGTAGGGGTTCTGAGACCGACTGTCACCCGTGGATCCTGATGGGGAAGAACAGAGGCTTCA
CTGTAGCTATAGTTTTCCACCAAGTCAATCAAATTAAAACATGACTCATTGTCCCCTCCAAAGATTCATAAAATTCTTGAGCTAAAGTGA
TCTTCTGAAGAAAAGCCACCTAACAATGTTAGGAGGCTCATAAAGCTCATTTCTCTTTTCCCTGGTATGCACAAATATCAAGCCTATAAA
AAAGTAATTATTTCCCCAAACCTGTAACCACTGCATTCGTTTTCTTTGGAGGAACATTGTAGCATTTCAGGAGGGTCGAGAGATCTAAAG
AGTTTGGTCTGAATGTGTGTCTGTACAATTCCCTTTGGCATTAAACTCTGAAACCTACAATCAATGGCCTTCAAATTGGTGTTAAATTGG
GAGAACACCCTACTGCTTTCTGAGTCTACGAGCAACAGAAAGACTGGTCTTAGTGCAATTAGGCAGGAGGGATTTGGACTCAGAAACAGC
CACAGAAGTATTTCTCAGCACTCCCAGTTCCTGCCAACTTAGCTGGAAACGATGCCACAGCGAGACCAGAAAGAGGAGTCGCCTTAAGGT
ATCCCTACAAAGTCACCTTTCTGATAAAAAGGAGGGAAAAAAAAGTTAGATATCTAAAATAAGCCTAGAATCTCACACACAGCTGTGACT
TCTAAGTGAAACTCTTTTCTCCCTCATGTCCTTAAATAGTCACAGAATCACACACAGCCTGACTTTTAAAGACAAGCTTGGCTACAGGAA
ATGAACCAACCCCAAAGACTCTTCTAACCTGTCTCCTGACTGGGCTCCTTCAGAAAGTGTTCTCCTGTTCCATCTGTAGGGCTGCTTACT
ACTGGAACCTAAAACAAAACCTGTTGTTTGTACCATCACTTTTTCTGGTGTTTCCTGTGCTTTTGTGATTCCAAGTCTGTTCATAAGTTC
TGAAGATAAATTATGTGAAATCATATTTTGGCATATGGGGGTGGAGGATGAATTCTTTACAGACTTTTTAAGATGATCCATTTGTACCAC

>98875_98875_1_WDR12-PARD3B_WDR12_chr2_203776159_ENST00000261015_PARD3B_chr2_206418048_ENST00000406610_length(amino acids)=131AA_BP=
MDRAGLGGTQLYGCSHGVLLPGILGSVRVLVWAAPTGPWSACFLIGWHSLVLGRGRRNVLSKGSFVLGSWRGWVVLRIPEICHPELCGAG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WDR12-PARD3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WDR12-PARD3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WDR12-PARD3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource