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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:WDR13-ST6GALNAC2 (FusionGDB2 ID:98879)

Fusion Gene Summary for WDR13-ST6GALNAC2

Fusion gene summary

Fusion gene information	Fusion gene name: WDR13-ST6GALNAC2
	Fusion gene ID: 98879
		Hgene	Tgene
	Gene symbol	WDR13	ST6GALNAC2
	Gene ID	64743	10610
	Gene name	WD repeat domain 13	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
	Synonyms	MG21	SAITL1\|SIAT7\|SIAT7B\|SIATL1\|ST6GalNAII\|STHM
	Cytomap	Xp11.23	17q25.1
	Type of gene	protein-coding	protein-coding
	Description	WD repeat-containing protein 13	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide B(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferaseSIAT7-BST6 (
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000492715, ENST00000218056, ENST00000376729,	ENST00000225276, ENST00000586520,
Fusion gene scores	* DoF score	6 X 4 X 4=96	9 X 4 X 6=216
	# samples	6	10
	** MAII score	log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/216*10)=-1.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: WDR13 [Title/Abstract] AND ST6GALNAC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	WDR13(48456425)-ST6GALNAC2(74574898), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ST6GALNAC2	GO:0006486	protein glycosylation	29251719
Tgene	ST6GALNAC2	GO:0006493	protein O-linked glycosylation	10742600
Tgene	ST6GALNAC2	GO:1990743	protein sialylation	10742600

Fusion gene breakpoints across WDR13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ST6GALNAC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-A4PD-01A	WDR13	chrX	48456425	+	ST6GALNAC2	chr17	74574898	-

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Fusion Gene ORF analysis for WDR13-ST6GALNAC2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000492715	ENST00000225276	WDR13	chrX	48456425	+	ST6GALNAC2	chr17	74574898	-
3UTR-5UTR	ENST00000492715	ENST00000586520	WDR13	chrX	48456425	+	ST6GALNAC2	chr17	74574898	-
5CDS-5UTR	ENST00000218056	ENST00000586520	WDR13	chrX	48456425	+	ST6GALNAC2	chr17	74574898	-
5CDS-5UTR	ENST00000376729	ENST00000586520	WDR13	chrX	48456425	+	ST6GALNAC2	chr17	74574898	-
In-frame	ENST00000218056	ENST00000225276	WDR13	chrX	48456425	+	ST6GALNAC2	chr17	74574898	-
In-frame	ENST00000376729	ENST00000225276	WDR13	chrX	48456425	+	ST6GALNAC2	chr17	74574898	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000376729

WDR13

chrX

48456425

ENST00000225276

ST6GALNAC2

chr17

74574898

1942

217

1216

391

ENST00000218056

WDR13

chrX

48456425

ENST00000225276

ST6GALNAC2

chr17

74574898

2271

546

460

1545

361

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000376729	ENST00000225276	WDR13	chrX	48456425	+	ST6GALNAC2	chr17	74574898	-	0.009818293	0.99018174
ENST00000218056	ENST00000225276	WDR13	chrX	48456425	+	ST6GALNAC2	chr17	74574898	-	0.006616957	0.993383

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Fusion Genomic Features for WDR13-ST6GALNAC2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WDR13-ST6GALNAC2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:48456425/chr17:74574898)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000218056

162_202

486.0

Repeat

Note=WD 1

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000218056

208_246

486.0

Repeat

Note=WD 2

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000218056

250_290

486.0

Repeat

Note=WD 3

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000218056

295_335

486.0

Repeat

Note=WD 4

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000218056

341_389

486.0

Repeat

Note=WD 5

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000218056

394_438

486.0

Repeat

Note=WD 6

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000218056

444_482

486.0

Repeat

Note=WD 7

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000376729

162_202

486.0

Repeat

Note=WD 1

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000376729

208_246

486.0

Repeat

Note=WD 2

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000376729

250_290

486.0

Repeat

Note=WD 3

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000376729

295_335

486.0

Repeat

Note=WD 4

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000376729

341_389

486.0

Repeat

Note=WD 5

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000376729

394_438

486.0

Repeat

Note=WD 6

Hgene

WDR13

chrX:48456425

chr17:74574898

ENST00000376729

444_482

486.0

Repeat

Note=WD 7

Tgene

ST6GALNAC2

chrX:48456425

chr17:74574898

ENST00000225276

1_7

375.0

Topological domain

Cytoplasmic

Tgene

ST6GALNAC2

chrX:48456425

chr17:74574898

ENST00000225276

29_374

375.0

Topological domain

Lumenal

Tgene

ST6GALNAC2

chrX:48456425

chr17:74574898

ENST00000225276

8_28

375.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for WDR13-ST6GALNAC2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>98879_98879_1_WDR13-ST6GALNAC2_WDR13_chrX_48456425_ENST00000218056_ST6GALNAC2_chr17_74574898_ENST00000225276_length(transcript)=2271nt_BP=546nt
CTTTCTGATAGCAGGCAGCCATCTTGCCTGGAGCCTGAGAAAGGGAGGAGAGACAGAAGGAACCGGCGACAGTGGTCTCAGGGCCGCTCC
GGGGGGCCTCAAGAACCGGAGGCAGCCCCGGAGGTGGTCCCCGATCCCGGGCTATGCTCTTGGATCTGAGAAGGGAAGGCGGAGGGCGGC
GGGGACAAGATGGGTGGAGAATGTCAAGCAAGGAATGCTAGGCGGGGGAGGGGCGTTGCTATGGCGACTGGGGAGGGGCGGTGTCTGTTC
TGAATCGCTGTGTGTCACCCGGGCGCTGCCCAGGAAGGGCAGGGCTGGGGTGATGACCATGGTAACACCCGGGGGGGAGTTCGTGACATC
TCCGGCGCGGAGGGACTCGATGTCTATGGCAATGGTCGCCTGGTGGAAGGGACGGAACTAGATCCCTTCGCTCGGGACGCTCACATTCCA
GGCCCTTGTCCTGCAGGCTGCCGCGGGCGGACACGCCAGAGGAGGAGGCCGGGGAATGGCCGCGGTGTGGCAGCAAGTCTTAGCAGTGGA
CGCGAGGGACACCACATCATTTGAAGCATTCTTTCAATCCAAGGCATCGAATTCTTGGACAGGAAAGGGCCAGGCCTGCCGACACCTGCT
TCACCTGGCCATTCAGCGGCACCCCCACTTCCGTGGCCTGTTCAATCTCTCCATTCCAGTGCTGCTGTGGGGGGACCTCTTCACCCCAGC
GCTCTGGGACCGCCTGAGCCAACACAAAGCCCCGTATGGCTGGCGGGGGCTCTCTCACCAAGTCATCGCCTCCACCCTGAGCCTTCTGAA
CGGCTCAGAGAGTGCCAAGCTGTTTGCCCCGCCCAGGGACACCCCTCCAAAGTGTATCCGGTGTGCCGTGGTGGGCAACGGAGGCATTCT
GAATGGGTCCCGCCAGGGTCCCAACATCGATGCCCATGACTATGTATTCAGACTCAATGGAGCTGTGATCAAAGGCTTCGAGCGCGATGT
GGGCACCAAGACTTCCTTCTATGGTTTCACTGTGAACACGATGAAGAACTCCCTCGTCTCCTACTGGAATCTGGGCTTCACCTCCGTGCC
ACAAGGACAGGACCTGCAGTATATCTTCATCCCCTCAGACATCCGCGACTATGTGATGCTGAGATCGGCCATTCTGGGCGTGCCTGTCCC
TGAGGGCCTAGATAAAGGGGACAGGCCGCACGCCTATTTTGGACCAGAAGCCTCTGCCAGTAAATTCAAGCTGCTACATCCGGACTTCAT
CAGCTACCTGACAGAAAGGTTCTTGAAATCAAAGTTGATTAACACACATTTTGGAGACCTATATATGCCTAGTACCGGGGCTCTCATGCT
GCTGACAGCTTTGCATACCTGTGACCAGGTCAGTGCCTATGGATTCATCACAAGCAACTACTGGAAATTTTCCGACCACTATTTCGAACG
AAAAATGAAGCCATTGATATTTTATGCAAACCACGATCTGTCCCTGGAAGCTGCCCTGTGGAGGGACCTGCACAAGGCCGGCATCCTTCA
GCTGTACCAGCGCTGACCCCAATGCACTGAGCCCTTTGCTTCTTCAAGAGTTGCGGCCCTGATCCTCTCAAGTGGCCAAAAGCTTTTTTA
ACTTTTCAATCTTCACCTTCCCTTGCCAACAGAGGGCACTGGGGTGAATTCAAGATTTTCATCGAGGTCTGTTCAATATAGGACACCCCA
GCTTGTCCTTGGCTCATCCAAGAACTCTTCTGTATCTAAAACAATACATCTCAATCTTGGCCAAGGGAAAATGGACTGCTTTGCTGGATT
GGCACTGAGCAACTTTAGGAAATGTCGGTGGAGTGTTCAGCAAGATCAGACAGCAGTCCAGGTCAAAGGCAAACACACACGCTCCAGCCC
AAATCCTCCTGGTGGCACATCCTACCCCAGATGCTAAAGTGATTCAAGGACTCCAGGACACCTCTTAAGAGCCTTTCTAAGAACATGATA
GGCTTACTTCTGCTCCATAATAAAGTGGGAGAAAAAAGCCAGAATATAACTTAAGACTAGATAACTGCGTACATGATGGACCATTTTTTT
TTTTTTGGCTGGGTAGAGAAATCATATAAAACGCAGGCTGTTTAGCATGGAGATGACTCTCAGAACACTGGGAGGGTCTGGCACTTGATG
GGGGTTAGTTGCTTGGCAGCCTGCCTGCCACTGAGGGAAGTCCCATTAGAGATGTATCACCACCTTGTCACCAACAGGATGATGTCACCA

>98879_98879_1_WDR13-ST6GALNAC2_WDR13_chrX_48456425_ENST00000218056_ST6GALNAC2_chr17_74574898_ENST00000225276_length(amino acids)=361AA_BP=28
MQAAAGGHARGGGRGMAAVWQQVLAVDARDTTSFEAFFQSKASNSWTGKGQACRHLLHLAIQRHPHFRGLFNLSIPVLLWGDLFTPALWD
RLSQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFAPPRDTPPKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTK
TSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYL
TERFLKSKLINTHFGDLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYFERKMKPLIFYANHDLSLEAALWRDLHKAGILQLYQ

--------------------------------------------------------------
>98879_98879_2_WDR13-ST6GALNAC2_WDR13_chrX_48456425_ENST00000376729_ST6GALNAC2_chr17_74574898_ENST00000225276_length(transcript)=1942nt_BP=217nt
TGGGCTCGGCAGTTCTTTCTGATAGCAGGCAGCCATCTTGCCTGGAGCCTGAGAAAGGGAGGAGAGACAGAAGGAACCGGCGACAGTGGT
CTCAGGGCCGCTCCGGGGGGCCTCAAGAACCGGAGGCAGCCCCGGAGGCTGCCGCGGGCGGACACGCCAGAGGAGGAGGCCGGGGAATGG
CCGCGGTGTGGCAGCAAGTCTTAGCAGTGGACGCGAGGGACACCACATCATTTGAAGCATTCTTTCAATCCAAGGCATCGAATTCTTGGA
CAGGAAAGGGCCAGGCCTGCCGACACCTGCTTCACCTGGCCATTCAGCGGCACCCCCACTTCCGTGGCCTGTTCAATCTCTCCATTCCAG
TGCTGCTGTGGGGGGACCTCTTCACCCCAGCGCTCTGGGACCGCCTGAGCCAACACAAAGCCCCGTATGGCTGGCGGGGGCTCTCTCACC
AAGTCATCGCCTCCACCCTGAGCCTTCTGAACGGCTCAGAGAGTGCCAAGCTGTTTGCCCCGCCCAGGGACACCCCTCCAAAGTGTATCC
GGTGTGCCGTGGTGGGCAACGGAGGCATTCTGAATGGGTCCCGCCAGGGTCCCAACATCGATGCCCATGACTATGTATTCAGACTCAATG
GAGCTGTGATCAAAGGCTTCGAGCGCGATGTGGGCACCAAGACTTCCTTCTATGGTTTCACTGTGAACACGATGAAGAACTCCCTCGTCT
CCTACTGGAATCTGGGCTTCACCTCCGTGCCACAAGGACAGGACCTGCAGTATATCTTCATCCCCTCAGACATCCGCGACTATGTGATGC
TGAGATCGGCCATTCTGGGCGTGCCTGTCCCTGAGGGCCTAGATAAAGGGGACAGGCCGCACGCCTATTTTGGACCAGAAGCCTCTGCCA
GTAAATTCAAGCTGCTACATCCGGACTTCATCAGCTACCTGACAGAAAGGTTCTTGAAATCAAAGTTGATTAACACACATTTTGGAGACC
TATATATGCCTAGTACCGGGGCTCTCATGCTGCTGACAGCTTTGCATACCTGTGACCAGGTCAGTGCCTATGGATTCATCACAAGCAACT
ACTGGAAATTTTCCGACCACTATTTCGAACGAAAAATGAAGCCATTGATATTTTATGCAAACCACGATCTGTCCCTGGAAGCTGCCCTGT
GGAGGGACCTGCACAAGGCCGGCATCCTTCAGCTGTACCAGCGCTGACCCCAATGCACTGAGCCCTTTGCTTCTTCAAGAGTTGCGGCCC
TGATCCTCTCAAGTGGCCAAAAGCTTTTTTAACTTTTCAATCTTCACCTTCCCTTGCCAACAGAGGGCACTGGGGTGAATTCAAGATTTT
CATCGAGGTCTGTTCAATATAGGACACCCCAGCTTGTCCTTGGCTCATCCAAGAACTCTTCTGTATCTAAAACAATACATCTCAATCTTG
GCCAAGGGAAAATGGACTGCTTTGCTGGATTGGCACTGAGCAACTTTAGGAAATGTCGGTGGAGTGTTCAGCAAGATCAGACAGCAGTCC
AGGTCAAAGGCAAACACACACGCTCCAGCCCAAATCCTCCTGGTGGCACATCCTACCCCAGATGCTAAAGTGATTCAAGGACTCCAGGAC
ACCTCTTAAGAGCCTTTCTAAGAACATGATAGGCTTACTTCTGCTCCATAATAAAGTGGGAGAAAAAAGCCAGAATATAACTTAAGACTA
GATAACTGCGTACATGATGGACCATTTTTTTTTTTTTGGCTGGGTAGAGAAATCATATAAAACGCAGGCTGTTTAGCATGGAGATGACTC
TCAGAACACTGGGAGGGTCTGGCACTTGATGGGGGTTAGTTGCTTGGCAGCCTGCCTGCCACTGAGGGAAGTCCCATTAGAGATGTATCA

>98879_98879_2_WDR13-ST6GALNAC2_WDR13_chrX_48456425_ENST00000376729_ST6GALNAC2_chr17_74574898_ENST00000225276_length(amino acids)=391AA_BP=58
MEPEKGRRDRRNRRQWSQGRSGGPQEPEAAPEAAAGGHARGGGRGMAAVWQQVLAVDARDTTSFEAFFQSKASNSWTGKGQACRHLLHLA
IQRHPHFRGLFNLSIPVLLWGDLFTPALWDRLSQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFAPPRDTPPKCIRCAVVGNGGILNGS
RQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDLQYIFIPSDIRDYVMLRSAILGVPVPEGL
DKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYFERKMK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WDR13-ST6GALNAC2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for WDR13-ST6GALNAC2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for WDR13-ST6GALNAC2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source