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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WDR34-ZER1 (FusionGDB2 ID:98952)

Fusion Gene Summary for WDR34-ZER1

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR34-ZER1
Fusion gene ID: 98952
HgeneTgene
Gene symbol

WDR34

ZER1

Gene ID

89891

10444

Gene nameWD repeat domain 34zyg-11 related cell cycle regulator
SynonymsCFAP133|DIC5|FAP133|SRTD11|bA216B9.3C9orf60|ZYG|ZYG11BL
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 34protein zer-1 homologZYG homologzer-1 homologzyg-11 homolog B-like proteinzyg11b-like protein
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000372715, ENST00000483181, 
ENST00000494461, ENST00000291900, 
Fusion gene scores* DoF score10 X 8 X 6=4808 X 8 X 5=320
# samples 1110
** MAII scorelog2(11/480*10)=-2.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR34 [Title/Abstract] AND ZER1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDR34(131402970)-ZER1(131505024), # samples:3
Anticipated loss of major functional domain due to fusion event.WDR34-ZER1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across WDR34 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZER1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-38-4630-01AWDR34chr9

131402969

-ZER1chr9

131505023

-
ChimerDB4LUADTCGA-38-4630-01AWDR34chr9

131402970

-ZER1chr9

131505024

-
ChimerDB4LUADTCGA-38-4630WDR34chr9

131402969

-ZER1chr9

131505024

-
ChimerDB4LUADTCGA-55-8506-01AWDR34chr9

131418820

-ZER1chr9

131495807

-


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Fusion Gene ORF analysis for WDR34-ZER1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000372715ENST00000494461WDR34chr9

131402969

-ZER1chr9

131505023

-
5CDS-intronENST00000372715ENST00000494461WDR34chr9

131402970

-ZER1chr9

131505024

-
5CDS-intronENST00000372715ENST00000494461WDR34chr9

131402969

-ZER1chr9

131505024

-
5CDS-intronENST00000372715ENST00000494461WDR34chr9

131418820

-ZER1chr9

131495807

-
Frame-shiftENST00000372715ENST00000291900WDR34chr9

131418820

-ZER1chr9

131495807

-
In-frameENST00000372715ENST00000291900WDR34chr9

131402969

-ZER1chr9

131505023

-
In-frameENST00000372715ENST00000291900WDR34chr9

131402970

-ZER1chr9

131505024

-
In-frameENST00000372715ENST00000291900WDR34chr9

131402969

-ZER1chr9

131505024

-
intron-3CDSENST00000483181ENST00000291900WDR34chr9

131402969

-ZER1chr9

131505023

-
intron-3CDSENST00000483181ENST00000291900WDR34chr9

131402970

-ZER1chr9

131505024

-
intron-3CDSENST00000483181ENST00000291900WDR34chr9

131402969

-ZER1chr9

131505024

-
intron-3CDSENST00000483181ENST00000291900WDR34chr9

131418820

-ZER1chr9

131495807

-
intron-intronENST00000483181ENST00000494461WDR34chr9

131402969

-ZER1chr9

131505023

-
intron-intronENST00000483181ENST00000494461WDR34chr9

131402970

-ZER1chr9

131505024

-
intron-intronENST00000483181ENST00000494461WDR34chr9

131402969

-ZER1chr9

131505024

-
intron-intronENST00000483181ENST00000494461WDR34chr9

131418820

-ZER1chr9

131495807

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372715WDR34chr9131402970-ENST00000291900ZER1chr9131505024-2989496251437470
ENST00000372715WDR34chr9131402969-ENST00000291900ZER1chr9131505024-2989496251437470
ENST00000372715WDR34chr9131402969-ENST00000291900ZER1chr9131505023-2989496251437470

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372715ENST00000291900WDR34chr9131402970-ZER1chr9131505024-0.0091020090.99089795
ENST00000372715ENST00000291900WDR34chr9131402969-ZER1chr9131505024-0.0091020090.99089795
ENST00000372715ENST00000291900WDR34chr9131402969-ZER1chr9131505023-0.0091020090.99089795

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Fusion Genomic Features for WDR34-ZER1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WDR34-ZER1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:131402970/chr9:131505024)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR34chr9:131402969chr9:131505023ENST00000372715-29106_131145537.0RegionDYNLRB1 binding
HgeneWDR34chr9:131402969chr9:131505023ENST00000372715-2980_93145537.0RegionDYNLL2 binding
HgeneWDR34chr9:131402969chr9:131505024ENST00000372715-29106_131145537.0RegionDYNLRB1 binding
HgeneWDR34chr9:131402969chr9:131505024ENST00000372715-2980_93145537.0RegionDYNLL2 binding
HgeneWDR34chr9:131402970chr9:131505024ENST00000372715-29106_131145537.0RegionDYNLRB1 binding
HgeneWDR34chr9:131402970chr9:131505024ENST00000372715-2980_93145537.0RegionDYNLL2 binding
TgeneZER1chr9:131402969chr9:131505023ENST00000291900716511_556453767.0RepeatNote=ARM 2
TgeneZER1chr9:131402969chr9:131505023ENST00000291900716558_600453767.0RepeatNote=ARM 3
TgeneZER1chr9:131402969chr9:131505023ENST00000291900716602_643453767.0RepeatNote=ARM 4
TgeneZER1chr9:131402969chr9:131505023ENST00000291900716714_756453767.0RepeatNote=ARM 5
TgeneZER1chr9:131402969chr9:131505024ENST00000291900716511_556453767.0RepeatNote=ARM 2
TgeneZER1chr9:131402969chr9:131505024ENST00000291900716558_600453767.0RepeatNote=ARM 3
TgeneZER1chr9:131402969chr9:131505024ENST00000291900716602_643453767.0RepeatNote=ARM 4
TgeneZER1chr9:131402969chr9:131505024ENST00000291900716714_756453767.0RepeatNote=ARM 5
TgeneZER1chr9:131402970chr9:131505024ENST00000291900716511_556453767.0RepeatNote=ARM 2
TgeneZER1chr9:131402970chr9:131505024ENST00000291900716558_600453767.0RepeatNote=ARM 3
TgeneZER1chr9:131402970chr9:131505024ENST00000291900716602_643453767.0RepeatNote=ARM 4
TgeneZER1chr9:131402970chr9:131505024ENST00000291900716714_756453767.0RepeatNote=ARM 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR34chr9:131402969chr9:131505023ENST00000372715-29215_255145537.0RepeatWD 1
HgeneWDR34chr9:131402969chr9:131505023ENST00000372715-29264_308145537.0RepeatWD 2
HgeneWDR34chr9:131402969chr9:131505023ENST00000372715-29390_430145537.0RepeatWD 3
HgeneWDR34chr9:131402969chr9:131505023ENST00000372715-29433_473145537.0RepeatWD 4
HgeneWDR34chr9:131402969chr9:131505023ENST00000372715-29480_520145537.0RepeatWD 5
HgeneWDR34chr9:131402969chr9:131505024ENST00000372715-29215_255145537.0RepeatWD 1
HgeneWDR34chr9:131402969chr9:131505024ENST00000372715-29264_308145537.0RepeatWD 2
HgeneWDR34chr9:131402969chr9:131505024ENST00000372715-29390_430145537.0RepeatWD 3
HgeneWDR34chr9:131402969chr9:131505024ENST00000372715-29433_473145537.0RepeatWD 4
HgeneWDR34chr9:131402969chr9:131505024ENST00000372715-29480_520145537.0RepeatWD 5
HgeneWDR34chr9:131402970chr9:131505024ENST00000372715-29215_255145537.0RepeatWD 1
HgeneWDR34chr9:131402970chr9:131505024ENST00000372715-29264_308145537.0RepeatWD 2
HgeneWDR34chr9:131402970chr9:131505024ENST00000372715-29390_430145537.0RepeatWD 3
HgeneWDR34chr9:131402970chr9:131505024ENST00000372715-29433_473145537.0RepeatWD 4
HgeneWDR34chr9:131402970chr9:131505024ENST00000372715-29480_520145537.0RepeatWD 5
TgeneZER1chr9:131402969chr9:131505023ENST00000291900716226_245453767.0RepeatNote=LRR 1
TgeneZER1chr9:131402969chr9:131505023ENST00000291900716246_268453767.0RepeatNote=LRR 2
TgeneZER1chr9:131402969chr9:131505023ENST00000291900716278_302453767.0RepeatNote=LRR 3
TgeneZER1chr9:131402969chr9:131505023ENST00000291900716427_467453767.0RepeatNote=ARM 1
TgeneZER1chr9:131402969chr9:131505024ENST00000291900716226_245453767.0RepeatNote=LRR 1
TgeneZER1chr9:131402969chr9:131505024ENST00000291900716246_268453767.0RepeatNote=LRR 2
TgeneZER1chr9:131402969chr9:131505024ENST00000291900716278_302453767.0RepeatNote=LRR 3
TgeneZER1chr9:131402969chr9:131505024ENST00000291900716427_467453767.0RepeatNote=ARM 1
TgeneZER1chr9:131402970chr9:131505024ENST00000291900716226_245453767.0RepeatNote=LRR 1
TgeneZER1chr9:131402970chr9:131505024ENST00000291900716246_268453767.0RepeatNote=LRR 2
TgeneZER1chr9:131402970chr9:131505024ENST00000291900716278_302453767.0RepeatNote=LRR 3
TgeneZER1chr9:131402970chr9:131505024ENST00000291900716427_467453767.0RepeatNote=ARM 1


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Fusion Gene Sequence for WDR34-ZER1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98952_98952_1_WDR34-ZER1_WDR34_chr9_131402969_ENST00000372715_ZER1_chr9_131505023_ENST00000291900_length(transcript)=2989nt_BP=496nt
GGCGGCGTAGGGGCGGAGGTCGCGCCTGAGTGCGTCCGCACGAGAGGGCGGAACCGTCTCCATGGCAACCCGCGCGCAGCCGGGGCCACT
CAGCCAGGCGGGAAGCGCTGGTGTTGCGGCGCTGGCGACAGTCGGGGTTGCGAGCGGCCCGGGGCCGGGGCGGCCAGGGCCGCTGCAGGA
CGAGACCCTGGGTGTGGCGTCCGTGCCCTCGCAGTGGAGGGCCGTCCAGGGCATCCGCTGGGAGACGAAAAGTTGCCAGACGGCCAGCAT
TGCCACTGCCAGTGCATCCGCCCAGGCCAGGAATCATGTGGACGCCCAGGTGCAGACGGAGGCCCCCGTGCCTGTCAGCGTGCAGCCCCC
GTCCCAGTATGACATACCCAGGCTCGCAGCCTTTCTTCGGAGAGTGGAGGCCATGGTCATCCGAGAGCTGAACAAGAATTGGCAGAGCCA
CGCGTTTGATGGCTTCGAGGTGAACTGGACCGAGCAGCAGCAGATGGTGCAGCGGAACTGCTGCCTGACGCTCTGCAACTTCAGCATCCC
CGAGGAGCTGGAATTCCAGTACCGCCGGGTCAACGAGCTCCTGCTCAGCATCCTCAACCCCACGCGGCAGGACGAGTCTATCCAGCGGAT
CGCCGTGCACCTGTGCAATGCCCTGGTCTGCCAGGTAGACAACGACCACAAGGAGGCCGTGGGCAAGATGGGCTTTGTCGTGACCATGCT
GAAGCTGATTCAGAAGAAGCTGCTGGACAAGACATGTGACCAGGTCATGGAGTTCTCCTGGAGTGCCCTGTGGAACATCACAGATGAAAC
TCCTGACAACTGCGAGATGTTCCTCAATTTCAACGGCATGAAGCTCTTCCTGGACTGCCTGAAGGAATTCCCAGAGAAGCAGGAACTGCA
TAGGAATATGCTAGGACTTTTGGGGAATGTGGCAGAAGTGAAGGAGCTGAGGCCTCAACTAATGACTTCCCAGTTCATCAGCGTCTTCAG
CAACCTGTTGGAGAGCAAGGCCGATGGGATCGAGGTTTCCTACAATGCCTGCGGCGTCCTCTCCCACATCATGTTTGATGGACCCGAGGC
CTGGGGCGTCTGTGAGCCCCAGCGTGAGGAGGTGGAGGAACGCATGTGGGCTGCCATCCAGAGCTGGGACATAAACTCTCGGAGAAACAT
CAATTACAGGTCATTTGAACCAATTCTCCGCCTCCTTCCCCAGGGAATCTCTCCTGTCAGCCAGCACTGGGCAACCTGGGCCCTGTATAA
CCTCGTGTCTGTCTACCCGGACAAGTACTGCCCTCTGCTGATCAAAGAAGGGGGGATGCCCCTTCTGAGGGACATAATTAAGATGGCGAC
CGCACGGCAGGAGACCAAGGAAATGGCCCGCAAGGTGATTGAGCACTGCAGTAACTTTAAAGAGGAGAACATGGACACGTCTAGATAGAG
GCCTCCGTCCCCATGGCCGCCACCGCTCTGGACCACAGGCGGGGAGGAAGCATGCTCAAGCAGCCCAGCGGGCGGGCCCCTTCCGAGGGA
GCCTCCCACGGAGTGAAGAGACATGGGGGACTTTTGCACAACCGACGCTTTTCCTTAATGTTAGTGAGATATATATATATTATATATATA
TATTTTTTTTTTGGTTAGGAAGTGTGAAGTTTTGTGTGTATGATTTCTGTGCAAAAACAAAAGCAACACTCCTGAGTCCTTGCAGCTTCC
TTGGCCATTCTCAAACCCACTCAGCCTTCATCGCTGACACACACACTCCTACCCCAACCAGACTAAATGCCTATAACGCTGTGAGTGTCC
AGTCCTTGTCCAGGAAACTCAGATCCCGGCCTGGCTTCCTTTCATGAGAGGAGCAGGCCTTGGACAGCGTATCGAGCATCCTGACCCACT
GCCCCTGCCTGAGAACGCCATCTCGGCTCCCGGGCACAGCTGATGGGGTTTGGGGATTAGAACTTACCCCACTGGGTCTCCCAAAAGCCT
TGGTGCTCCCGGCTGTGGGCCATCTGGGGCAGGAAAGTGAGCCATTCCTAGGCTGAGGTCCAGGCAGCCCTGCCCCTGAAGACCCTCTAG
GAGCAGGGCACCCAGTGGCCCTGCTGCTGTCCAGCCAGGCCTGCCTGAGGCCACGCTGCTATGGAGGCTGCCTCCTAGTCTCCCACCAGG
TCCCAGGCTGTGGAAAGCCCCAGCCCAGGGATGGTCAGAACTCAGGGGCAGATTCCACTGCCCCTTCTGCCAAACACATCCAGAACCTGC
CCTCAGCCCTGGAAGCTAGCATCTTCTGGGGCCAGGGGCTTGCTTCCTCGCTCCATAGCCCTCAACTGCCCAGGCGCTCCCACCAGCAGA
ACTGAGCCTGCCTCCTCCTCCCAGCCTGCCCCGCTGCCCAGAGGACCCCACGCCTCTCAGAGGCAGAGGTCCCATGACAGCCTTTGACCC
ACAACGGCCACACAGCCGCCTCCAGACCAGCACTCGGACTGCCCTGCAGTGGCCGCTTGGGCCTCCCTGGCGGTCCCGCCCTGCCCTAGG
CTTTACCTTGGAAGCCTGAGAGGCGCCGGCTCTCTTGCTCCTCCATCGATGGACACTGCATTGCTTCTCATCGGACACTTGTGGAGCGCA
GGGGCCTGGGGAGCAGCGCTAACCCTGGAGGCAGCCTTTGGGTGATGGCTTTTTCTTCCCTTTTCCTCCCGCGGGCCTGTTTTCAGGTGT
TCCTAGCATTTCTGCCTCCAGGCAGGACGGCAGGGGTGAGCAGCTTTGGGAGAGACACCTGGCCTTTTTCTCCTGGAGCCTCTCCCTCCC
GGCCCTGGGAAGTGGGCGCAGCCCTGTGTTCCCCCAGCTTGGCAGATGGGCTGCATGCGGCGCTCCCTTCCTTCCCACGCTCAGCGGCCC
CGGCCAGACCCTGGCAGACTTCACACCTCATTGCTTTACCCCCTGGGGCCTGGGGAAATGTCTGTACTTTGGGAAGTCACAGAAATACAT

>98952_98952_1_WDR34-ZER1_WDR34_chr9_131402969_ENST00000372715_ZER1_chr9_131505023_ENST00000291900_length(amino acids)=470AA_BP=157
MSASAREGGTVSMATRAQPGPLSQAGSAGVAALATVGVASGPGPGRPGPLQDETLGVASVPSQWRAVQGIRWETKSCQTASIATASASAQ
ARNHVDAQVQTEAPVPVSVQPPSQYDIPRLAAFLRRVEAMVIRELNKNWQSHAFDGFEVNWTEQQQMVQRNCCLTLCNFSIPEELEFQYR
RVNELLLSILNPTRQDESIQRIAVHLCNALVCQVDNDHKEAVGKMGFVVTMLKLIQKKLLDKTCDQVMEFSWSALWNITDETPDNCEMFL
NFNGMKLFLDCLKEFPEKQELHRNMLGLLGNVAEVKELRPQLMTSQFISVFSNLLESKADGIEVSYNACGVLSHIMFDGPEAWGVCEPQR
EEVEERMWAAIQSWDINSRRNINYRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPDKYCPLLIKEGGMPLLRDIIKMATARQETKEM

--------------------------------------------------------------
>98952_98952_2_WDR34-ZER1_WDR34_chr9_131402969_ENST00000372715_ZER1_chr9_131505024_ENST00000291900_length(transcript)=2989nt_BP=496nt
GGCGGCGTAGGGGCGGAGGTCGCGCCTGAGTGCGTCCGCACGAGAGGGCGGAACCGTCTCCATGGCAACCCGCGCGCAGCCGGGGCCACT
CAGCCAGGCGGGAAGCGCTGGTGTTGCGGCGCTGGCGACAGTCGGGGTTGCGAGCGGCCCGGGGCCGGGGCGGCCAGGGCCGCTGCAGGA
CGAGACCCTGGGTGTGGCGTCCGTGCCCTCGCAGTGGAGGGCCGTCCAGGGCATCCGCTGGGAGACGAAAAGTTGCCAGACGGCCAGCAT
TGCCACTGCCAGTGCATCCGCCCAGGCCAGGAATCATGTGGACGCCCAGGTGCAGACGGAGGCCCCCGTGCCTGTCAGCGTGCAGCCCCC
GTCCCAGTATGACATACCCAGGCTCGCAGCCTTTCTTCGGAGAGTGGAGGCCATGGTCATCCGAGAGCTGAACAAGAATTGGCAGAGCCA
CGCGTTTGATGGCTTCGAGGTGAACTGGACCGAGCAGCAGCAGATGGTGCAGCGGAACTGCTGCCTGACGCTCTGCAACTTCAGCATCCC
CGAGGAGCTGGAATTCCAGTACCGCCGGGTCAACGAGCTCCTGCTCAGCATCCTCAACCCCACGCGGCAGGACGAGTCTATCCAGCGGAT
CGCCGTGCACCTGTGCAATGCCCTGGTCTGCCAGGTAGACAACGACCACAAGGAGGCCGTGGGCAAGATGGGCTTTGTCGTGACCATGCT
GAAGCTGATTCAGAAGAAGCTGCTGGACAAGACATGTGACCAGGTCATGGAGTTCTCCTGGAGTGCCCTGTGGAACATCACAGATGAAAC
TCCTGACAACTGCGAGATGTTCCTCAATTTCAACGGCATGAAGCTCTTCCTGGACTGCCTGAAGGAATTCCCAGAGAAGCAGGAACTGCA
TAGGAATATGCTAGGACTTTTGGGGAATGTGGCAGAAGTGAAGGAGCTGAGGCCTCAACTAATGACTTCCCAGTTCATCAGCGTCTTCAG
CAACCTGTTGGAGAGCAAGGCCGATGGGATCGAGGTTTCCTACAATGCCTGCGGCGTCCTCTCCCACATCATGTTTGATGGACCCGAGGC
CTGGGGCGTCTGTGAGCCCCAGCGTGAGGAGGTGGAGGAACGCATGTGGGCTGCCATCCAGAGCTGGGACATAAACTCTCGGAGAAACAT
CAATTACAGGTCATTTGAACCAATTCTCCGCCTCCTTCCCCAGGGAATCTCTCCTGTCAGCCAGCACTGGGCAACCTGGGCCCTGTATAA
CCTCGTGTCTGTCTACCCGGACAAGTACTGCCCTCTGCTGATCAAAGAAGGGGGGATGCCCCTTCTGAGGGACATAATTAAGATGGCGAC
CGCACGGCAGGAGACCAAGGAAATGGCCCGCAAGGTGATTGAGCACTGCAGTAACTTTAAAGAGGAGAACATGGACACGTCTAGATAGAG
GCCTCCGTCCCCATGGCCGCCACCGCTCTGGACCACAGGCGGGGAGGAAGCATGCTCAAGCAGCCCAGCGGGCGGGCCCCTTCCGAGGGA
GCCTCCCACGGAGTGAAGAGACATGGGGGACTTTTGCACAACCGACGCTTTTCCTTAATGTTAGTGAGATATATATATATTATATATATA
TATTTTTTTTTTGGTTAGGAAGTGTGAAGTTTTGTGTGTATGATTTCTGTGCAAAAACAAAAGCAACACTCCTGAGTCCTTGCAGCTTCC
TTGGCCATTCTCAAACCCACTCAGCCTTCATCGCTGACACACACACTCCTACCCCAACCAGACTAAATGCCTATAACGCTGTGAGTGTCC
AGTCCTTGTCCAGGAAACTCAGATCCCGGCCTGGCTTCCTTTCATGAGAGGAGCAGGCCTTGGACAGCGTATCGAGCATCCTGACCCACT
GCCCCTGCCTGAGAACGCCATCTCGGCTCCCGGGCACAGCTGATGGGGTTTGGGGATTAGAACTTACCCCACTGGGTCTCCCAAAAGCCT
TGGTGCTCCCGGCTGTGGGCCATCTGGGGCAGGAAAGTGAGCCATTCCTAGGCTGAGGTCCAGGCAGCCCTGCCCCTGAAGACCCTCTAG
GAGCAGGGCACCCAGTGGCCCTGCTGCTGTCCAGCCAGGCCTGCCTGAGGCCACGCTGCTATGGAGGCTGCCTCCTAGTCTCCCACCAGG
TCCCAGGCTGTGGAAAGCCCCAGCCCAGGGATGGTCAGAACTCAGGGGCAGATTCCACTGCCCCTTCTGCCAAACACATCCAGAACCTGC
CCTCAGCCCTGGAAGCTAGCATCTTCTGGGGCCAGGGGCTTGCTTCCTCGCTCCATAGCCCTCAACTGCCCAGGCGCTCCCACCAGCAGA
ACTGAGCCTGCCTCCTCCTCCCAGCCTGCCCCGCTGCCCAGAGGACCCCACGCCTCTCAGAGGCAGAGGTCCCATGACAGCCTTTGACCC
ACAACGGCCACACAGCCGCCTCCAGACCAGCACTCGGACTGCCCTGCAGTGGCCGCTTGGGCCTCCCTGGCGGTCCCGCCCTGCCCTAGG
CTTTACCTTGGAAGCCTGAGAGGCGCCGGCTCTCTTGCTCCTCCATCGATGGACACTGCATTGCTTCTCATCGGACACTTGTGGAGCGCA
GGGGCCTGGGGAGCAGCGCTAACCCTGGAGGCAGCCTTTGGGTGATGGCTTTTTCTTCCCTTTTCCTCCCGCGGGCCTGTTTTCAGGTGT
TCCTAGCATTTCTGCCTCCAGGCAGGACGGCAGGGGTGAGCAGCTTTGGGAGAGACACCTGGCCTTTTTCTCCTGGAGCCTCTCCCTCCC
GGCCCTGGGAAGTGGGCGCAGCCCTGTGTTCCCCCAGCTTGGCAGATGGGCTGCATGCGGCGCTCCCTTCCTTCCCACGCTCAGCGGCCC
CGGCCAGACCCTGGCAGACTTCACACCTCATTGCTTTACCCCCTGGGGCCTGGGGAAATGTCTGTACTTTGGGAAGTCACAGAAATACAT

>98952_98952_2_WDR34-ZER1_WDR34_chr9_131402969_ENST00000372715_ZER1_chr9_131505024_ENST00000291900_length(amino acids)=470AA_BP=157
MSASAREGGTVSMATRAQPGPLSQAGSAGVAALATVGVASGPGPGRPGPLQDETLGVASVPSQWRAVQGIRWETKSCQTASIATASASAQ
ARNHVDAQVQTEAPVPVSVQPPSQYDIPRLAAFLRRVEAMVIRELNKNWQSHAFDGFEVNWTEQQQMVQRNCCLTLCNFSIPEELEFQYR
RVNELLLSILNPTRQDESIQRIAVHLCNALVCQVDNDHKEAVGKMGFVVTMLKLIQKKLLDKTCDQVMEFSWSALWNITDETPDNCEMFL
NFNGMKLFLDCLKEFPEKQELHRNMLGLLGNVAEVKELRPQLMTSQFISVFSNLLESKADGIEVSYNACGVLSHIMFDGPEAWGVCEPQR
EEVEERMWAAIQSWDINSRRNINYRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPDKYCPLLIKEGGMPLLRDIIKMATARQETKEM

--------------------------------------------------------------
>98952_98952_3_WDR34-ZER1_WDR34_chr9_131402970_ENST00000372715_ZER1_chr9_131505024_ENST00000291900_length(transcript)=2989nt_BP=496nt
GGCGGCGTAGGGGCGGAGGTCGCGCCTGAGTGCGTCCGCACGAGAGGGCGGAACCGTCTCCATGGCAACCCGCGCGCAGCCGGGGCCACT
CAGCCAGGCGGGAAGCGCTGGTGTTGCGGCGCTGGCGACAGTCGGGGTTGCGAGCGGCCCGGGGCCGGGGCGGCCAGGGCCGCTGCAGGA
CGAGACCCTGGGTGTGGCGTCCGTGCCCTCGCAGTGGAGGGCCGTCCAGGGCATCCGCTGGGAGACGAAAAGTTGCCAGACGGCCAGCAT
TGCCACTGCCAGTGCATCCGCCCAGGCCAGGAATCATGTGGACGCCCAGGTGCAGACGGAGGCCCCCGTGCCTGTCAGCGTGCAGCCCCC
GTCCCAGTATGACATACCCAGGCTCGCAGCCTTTCTTCGGAGAGTGGAGGCCATGGTCATCCGAGAGCTGAACAAGAATTGGCAGAGCCA
CGCGTTTGATGGCTTCGAGGTGAACTGGACCGAGCAGCAGCAGATGGTGCAGCGGAACTGCTGCCTGACGCTCTGCAACTTCAGCATCCC
CGAGGAGCTGGAATTCCAGTACCGCCGGGTCAACGAGCTCCTGCTCAGCATCCTCAACCCCACGCGGCAGGACGAGTCTATCCAGCGGAT
CGCCGTGCACCTGTGCAATGCCCTGGTCTGCCAGGTAGACAACGACCACAAGGAGGCCGTGGGCAAGATGGGCTTTGTCGTGACCATGCT
GAAGCTGATTCAGAAGAAGCTGCTGGACAAGACATGTGACCAGGTCATGGAGTTCTCCTGGAGTGCCCTGTGGAACATCACAGATGAAAC
TCCTGACAACTGCGAGATGTTCCTCAATTTCAACGGCATGAAGCTCTTCCTGGACTGCCTGAAGGAATTCCCAGAGAAGCAGGAACTGCA
TAGGAATATGCTAGGACTTTTGGGGAATGTGGCAGAAGTGAAGGAGCTGAGGCCTCAACTAATGACTTCCCAGTTCATCAGCGTCTTCAG
CAACCTGTTGGAGAGCAAGGCCGATGGGATCGAGGTTTCCTACAATGCCTGCGGCGTCCTCTCCCACATCATGTTTGATGGACCCGAGGC
CTGGGGCGTCTGTGAGCCCCAGCGTGAGGAGGTGGAGGAACGCATGTGGGCTGCCATCCAGAGCTGGGACATAAACTCTCGGAGAAACAT
CAATTACAGGTCATTTGAACCAATTCTCCGCCTCCTTCCCCAGGGAATCTCTCCTGTCAGCCAGCACTGGGCAACCTGGGCCCTGTATAA
CCTCGTGTCTGTCTACCCGGACAAGTACTGCCCTCTGCTGATCAAAGAAGGGGGGATGCCCCTTCTGAGGGACATAATTAAGATGGCGAC
CGCACGGCAGGAGACCAAGGAAATGGCCCGCAAGGTGATTGAGCACTGCAGTAACTTTAAAGAGGAGAACATGGACACGTCTAGATAGAG
GCCTCCGTCCCCATGGCCGCCACCGCTCTGGACCACAGGCGGGGAGGAAGCATGCTCAAGCAGCCCAGCGGGCGGGCCCCTTCCGAGGGA
GCCTCCCACGGAGTGAAGAGACATGGGGGACTTTTGCACAACCGACGCTTTTCCTTAATGTTAGTGAGATATATATATATTATATATATA
TATTTTTTTTTTGGTTAGGAAGTGTGAAGTTTTGTGTGTATGATTTCTGTGCAAAAACAAAAGCAACACTCCTGAGTCCTTGCAGCTTCC
TTGGCCATTCTCAAACCCACTCAGCCTTCATCGCTGACACACACACTCCTACCCCAACCAGACTAAATGCCTATAACGCTGTGAGTGTCC
AGTCCTTGTCCAGGAAACTCAGATCCCGGCCTGGCTTCCTTTCATGAGAGGAGCAGGCCTTGGACAGCGTATCGAGCATCCTGACCCACT
GCCCCTGCCTGAGAACGCCATCTCGGCTCCCGGGCACAGCTGATGGGGTTTGGGGATTAGAACTTACCCCACTGGGTCTCCCAAAAGCCT
TGGTGCTCCCGGCTGTGGGCCATCTGGGGCAGGAAAGTGAGCCATTCCTAGGCTGAGGTCCAGGCAGCCCTGCCCCTGAAGACCCTCTAG
GAGCAGGGCACCCAGTGGCCCTGCTGCTGTCCAGCCAGGCCTGCCTGAGGCCACGCTGCTATGGAGGCTGCCTCCTAGTCTCCCACCAGG
TCCCAGGCTGTGGAAAGCCCCAGCCCAGGGATGGTCAGAACTCAGGGGCAGATTCCACTGCCCCTTCTGCCAAACACATCCAGAACCTGC
CCTCAGCCCTGGAAGCTAGCATCTTCTGGGGCCAGGGGCTTGCTTCCTCGCTCCATAGCCCTCAACTGCCCAGGCGCTCCCACCAGCAGA
ACTGAGCCTGCCTCCTCCTCCCAGCCTGCCCCGCTGCCCAGAGGACCCCACGCCTCTCAGAGGCAGAGGTCCCATGACAGCCTTTGACCC
ACAACGGCCACACAGCCGCCTCCAGACCAGCACTCGGACTGCCCTGCAGTGGCCGCTTGGGCCTCCCTGGCGGTCCCGCCCTGCCCTAGG
CTTTACCTTGGAAGCCTGAGAGGCGCCGGCTCTCTTGCTCCTCCATCGATGGACACTGCATTGCTTCTCATCGGACACTTGTGGAGCGCA
GGGGCCTGGGGAGCAGCGCTAACCCTGGAGGCAGCCTTTGGGTGATGGCTTTTTCTTCCCTTTTCCTCCCGCGGGCCTGTTTTCAGGTGT
TCCTAGCATTTCTGCCTCCAGGCAGGACGGCAGGGGTGAGCAGCTTTGGGAGAGACACCTGGCCTTTTTCTCCTGGAGCCTCTCCCTCCC
GGCCCTGGGAAGTGGGCGCAGCCCTGTGTTCCCCCAGCTTGGCAGATGGGCTGCATGCGGCGCTCCCTTCCTTCCCACGCTCAGCGGCCC
CGGCCAGACCCTGGCAGACTTCACACCTCATTGCTTTACCCCCTGGGGCCTGGGGAAATGTCTGTACTTTGGGAAGTCACAGAAATACAT

>98952_98952_3_WDR34-ZER1_WDR34_chr9_131402970_ENST00000372715_ZER1_chr9_131505024_ENST00000291900_length(amino acids)=470AA_BP=157
MSASAREGGTVSMATRAQPGPLSQAGSAGVAALATVGVASGPGPGRPGPLQDETLGVASVPSQWRAVQGIRWETKSCQTASIATASASAQ
ARNHVDAQVQTEAPVPVSVQPPSQYDIPRLAAFLRRVEAMVIRELNKNWQSHAFDGFEVNWTEQQQMVQRNCCLTLCNFSIPEELEFQYR
RVNELLLSILNPTRQDESIQRIAVHLCNALVCQVDNDHKEAVGKMGFVVTMLKLIQKKLLDKTCDQVMEFSWSALWNITDETPDNCEMFL
NFNGMKLFLDCLKEFPEKQELHRNMLGLLGNVAEVKELRPQLMTSQFISVFSNLLESKADGIEVSYNACGVLSHIMFDGPEAWGVCEPQR
EEVEERMWAAIQSWDINSRRNINYRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPDKYCPLLIKEGGMPLLRDIIKMATARQETKEM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WDR34-ZER1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WDR34-ZER1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WDR34-ZER1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource