FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:WDR37-FAM107B (FusionGDB2 ID:98963)

Fusion Gene Summary for WDR37-FAM107B

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR37-FAM107B
Fusion gene ID: 98963
HgeneTgene
Gene symbol

WDR37

FAM107B

Gene ID

22884

83641

Gene nameWD repeat domain 37family with sequence similarity 107 member B
SynonymsNOCGUSC10orf45|HITS
Cytomap

10p15.3

10p13

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 37protein FAM107BFAM107B/CDNF fusionheat shock-inducible tumor small protein
Modification date2020032220200313
UniProtAcc.

Q9H098

Ensembl transtripts involved in fusion geneENST00000263150, ENST00000358220, 
ENST00000381329, ENST00000482165, 
ENST00000378458, ENST00000378462, 
ENST00000378465, ENST00000378467, 
ENST00000378470, ENST00000468747, 
ENST00000471815, ENST00000478076, 
ENST00000479731, ENST00000496330, 
ENST00000181796, 
Fusion gene scores* DoF score11 X 8 X 6=52811 X 9 X 6=594
# samples 1112
** MAII scorelog2(11/528*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/594*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR37 [Title/Abstract] AND FAM107B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDR37(1142186)-FAM107B(14709690), # samples:2
Anticipated loss of major functional domain due to fusion event.WDR37-FAM107B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across WDR37 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM107B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CU-A3QU-01AWDR37chr10

1142186

-FAM107Bchr10

14709690

-
ChimerDB4BLCATCGA-CU-A3QUWDR37chr10

1142186

+FAM107Bchr10

14709690

-


Top

Fusion Gene ORF analysis for WDR37-FAM107B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263150ENST00000378458WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000263150ENST00000378462WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000263150ENST00000378465WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000263150ENST00000378467WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000263150ENST00000378470WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000263150ENST00000468747WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000263150ENST00000471815WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000263150ENST00000478076WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000263150ENST00000479731WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000263150ENST00000496330WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000358220ENST00000378458WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000358220ENST00000378462WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000358220ENST00000378465WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000358220ENST00000378467WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000358220ENST00000378470WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000358220ENST00000468747WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000358220ENST00000471815WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000358220ENST00000478076WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000358220ENST00000479731WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000358220ENST00000496330WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000381329ENST00000378458WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000381329ENST00000378462WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000381329ENST00000378465WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000381329ENST00000378467WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000381329ENST00000378470WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000381329ENST00000468747WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000381329ENST00000471815WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000381329ENST00000478076WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000381329ENST00000479731WDR37chr10

1142186

+FAM107Bchr10

14709690

-
5CDS-intronENST00000381329ENST00000496330WDR37chr10

1142186

+FAM107Bchr10

14709690

-
Frame-shiftENST00000381329ENST00000181796WDR37chr10

1142186

+FAM107Bchr10

14709690

-
In-frameENST00000263150ENST00000181796WDR37chr10

1142186

+FAM107Bchr10

14709690

-
In-frameENST00000358220ENST00000181796WDR37chr10

1142186

+FAM107Bchr10

14709690

-
intron-3CDSENST00000482165ENST00000181796WDR37chr10

1142186

+FAM107Bchr10

14709690

-
intron-intronENST00000482165ENST00000378458WDR37chr10

1142186

+FAM107Bchr10

14709690

-
intron-intronENST00000482165ENST00000378462WDR37chr10

1142186

+FAM107Bchr10

14709690

-
intron-intronENST00000482165ENST00000378465WDR37chr10

1142186

+FAM107Bchr10

14709690

-
intron-intronENST00000482165ENST00000378467WDR37chr10

1142186

+FAM107Bchr10

14709690

-
intron-intronENST00000482165ENST00000378470WDR37chr10

1142186

+FAM107Bchr10

14709690

-
intron-intronENST00000482165ENST00000468747WDR37chr10

1142186

+FAM107Bchr10

14709690

-
intron-intronENST00000482165ENST00000471815WDR37chr10

1142186

+FAM107Bchr10

14709690

-
intron-intronENST00000482165ENST00000478076WDR37chr10

1142186

+FAM107Bchr10

14709690

-
intron-intronENST00000482165ENST00000479731WDR37chr10

1142186

+FAM107Bchr10

14709690

-
intron-intronENST00000482165ENST00000496330WDR37chr10

1142186

+FAM107Bchr10

14709690

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358220WDR37chr101142186+ENST00000181796FAM107Bchr1014709690-40108701441379411
ENST00000263150WDR37chr101142186+ENST00000181796FAM107Bchr1014709690-40178771511386411

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358220ENST00000181796WDR37chr101142186+FAM107Bchr1014709690-0.0009629530.999037
ENST00000263150ENST00000181796WDR37chr101142186+FAM107Bchr1014709690-0.0010596610.9989403

Top

Fusion Genomic Features for WDR37-FAM107B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for WDR37-FAM107B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:1142186/chr10:14709690)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAM107B

Q9H098

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR37chr10:1142186chr10:14709690ENST00000263150+914154_194242495.0RepeatNote=WD 1
HgeneWDR37chr10:1142186chr10:14709690ENST00000263150+914197_236242495.0RepeatNote=WD 2
HgeneWDR37chr10:1142186chr10:14709690ENST00000358220+914154_194242495.0RepeatNote=WD 1
HgeneWDR37chr10:1142186chr10:14709690ENST00000358220+914197_236242495.0RepeatNote=WD 2
TgeneFAM107Bchr10:1142186chr10:14709690ENST000003784580561_1120132.0Coiled coilOntology_term=ECO:0000255
TgeneFAM107Bchr10:1142186chr10:14709690ENST000003784620461_1120132.0Coiled coilOntology_term=ECO:0000255
TgeneFAM107Bchr10:1142186chr10:14709690ENST000003784650461_1120132.0Coiled coilOntology_term=ECO:0000255
TgeneFAM107Bchr10:1142186chr10:14709690ENST000003784670561_1120132.0Coiled coilOntology_term=ECO:0000255
TgeneFAM107Bchr10:1142186chr10:14709690ENST000003784700461_1120132.0Coiled coilOntology_term=ECO:0000255
TgeneFAM107Bchr10:1142186chr10:14709690ENST000004687470461_1120132.0Coiled coilOntology_term=ECO:0000255
TgeneFAM107Bchr10:1142186chr10:14709690ENST000004780760461_1120132.0Coiled coilOntology_term=ECO:0000255
TgeneFAM107Bchr10:1142186chr10:14709690ENST000004797310461_1120132.0Coiled coilOntology_term=ECO:0000255
TgeneFAM107Bchr10:1142186chr10:14709690ENST000004963300561_1120132.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR37chr10:1142186chr10:14709690ENST00000263150+914279_318242495.0RepeatNote=WD 3
HgeneWDR37chr10:1142186chr10:14709690ENST00000263150+914321_360242495.0RepeatNote=WD 4
HgeneWDR37chr10:1142186chr10:14709690ENST00000263150+914365_403242495.0RepeatNote=WD 5
HgeneWDR37chr10:1142186chr10:14709690ENST00000263150+914406_445242495.0RepeatNote=WD 6
HgeneWDR37chr10:1142186chr10:14709690ENST00000263150+914452_493242495.0RepeatNote=WD 7
HgeneWDR37chr10:1142186chr10:14709690ENST00000358220+914279_318242495.0RepeatNote=WD 3
HgeneWDR37chr10:1142186chr10:14709690ENST00000358220+914321_360242495.0RepeatNote=WD 4
HgeneWDR37chr10:1142186chr10:14709690ENST00000358220+914365_403242495.0RepeatNote=WD 5
HgeneWDR37chr10:1142186chr10:14709690ENST00000358220+914406_445242495.0RepeatNote=WD 6
HgeneWDR37chr10:1142186chr10:14709690ENST00000358220+914452_493242495.0RepeatNote=WD 7
TgeneFAM107Bchr10:1142186chr10:14709690ENST000001817960561_112137307.0Coiled coilOntology_term=ECO:0000255


Top

Fusion Gene Sequence for WDR37-FAM107B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98963_98963_1_WDR37-FAM107B_WDR37_chr10_1142186_ENST00000263150_FAM107B_chr10_14709690_ENST00000181796_length(transcript)=4017nt_BP=877nt
GCGGTGTCCTGCGCGTCTTCGGGTCAGTACGGGGGGCCGCGTCGTAGGGACTCACTGGCGGTGCGCGACCTGGGCTGGCTCCGGGGGTGG
CGGGCGCAGCTGCTGTGACAGCTTATTGCAGGAGTGACCAGGACACTACCTCCTAGAAGTAATGCCCACAGAAAGCGCAAGTTGTTCGAC
TGCTCGCCAAACAAAACAGAAGCGCAAATCCCATAGCCTTTCTATACGAAGAACTAACAGCTCGGAGCAGGAGAGGACGGGACTGCCAAG
AGACATGTTAGAAGGACAAGATTCTAAACTGCCTTCCTCGGTTCGCAGTACACTTCTGGAACTGTTTGGTCAAATAGAAAGAGAATTTGA
AAACCTTTATATCGAAAACTTAGAATTACGTAGAGAAATCGACACTCTTAATGAACGTTTAGCTGCTGAAGGACAAGCGATTGATGGAGC
AGAGCTGAGTAAGGGCCAACTCAAAACAAAAGCCAGTCACAGCACCAGCCAGCTCTCCCAGAAACTGAAGACCACTTACAAGGCTTCCAC
CAGCAAGATTGTCTCCAGCTTTAAGACCACGACATCGAGAGCTGCCTGCCAGCTCGTGAAGGAGTACATCGGCCACCGGGACGGCATCTG
GGATGTCAGCGTGGCCAAGACACAGCCAGTGGTGCTCGGGACTGCATCAGCCGATCACACGGCTTTGCTGTGGAGCATAGAGACAGGGAA
GTGCCTAGTCAAGTACGCAGGCCACGTGGGCTCAGTAAATTCTATCAAATTTCATCCCTCAGAGCAGTTGGCTCTCACTGCTTCTGGAGA
TCAGACTGCTCATATCTGGAGATACGCGGTGCAGCTGCCGACACCCCAGCCTGTTGCTGACACTAGTGAAGAAGAATTTCGAGAAGAACC
TAAATGCCTCGAGCTGGAGCAGAAAATGACATCAGACAGCCCACCTGAGGATATTGACCATAAGGACTCATATCTCATTACAAGAAGCAT
CATGGCCGAGCCAGACTACATAGAAGATGACAATCCTGAACTCATTAGGCCTCAGAAACTGATCAATCCTGTAAAAACCTCCCGGAACCA
TCAAGATCTTCACAGAGAACTTCTTATGAATCAAAAAAGGGGTCTTGCTCCTCAGAACAAACCAGAATTGCAGAAGGTGATGGAAAAAAG
AAAACGAGACCAAGTAATAAAGCAGAAGGAAGAAGAAGCACAGAAGAAGAAATCTGACTTGGAAATAGAGCTATTAAAACGGCAGCAGAA
GTTGGAGCAGCTTGAACTTGAGAAGCAGAAATTGCAAGAAGAGCAAGAAAATGCCCCCGAGTTTGTGAAGGTGAAAGGCAATCTCAGGAG
AACAGGCCAAGAAGTCGCCCAAGCCCAGGAGTCCTAGGCTGAGGCTGCACCAAGACCTCGTGTGTCACCCCACAGAGCTGTCTGTGGGTG
CCTTCTCAATCTCAGGGCAAAAGCCCCTGGAGAATATTTCAGCCAGCAGAGAATTTTGACTTGCAGTAGGATTTGGTTTGATTTTCCTAC
GATCTGGGTGGATGCCTTGCCTGTGACAGTTGCAGTTCCTATTCGCCAAATGAAGGGCAGTGCCCCGCACGTAAGTTGGAATGATGGACC
TGTGTTCAGAGACTTAACAGAACCAACAAGCAAAACAAGTGAGAACAGGAAAAAGGAAGAGGACACTGGAATCAATTCTTGAGAGTTGCA
CTACTTGGTTTTTCTTCCATTCCAAGTTTCGTGGGACCCAGAGCCTTTTTTCTTTTAAAAGCTAAAAAACAAGTGTTTAATTCCTCTTTT
TGTTATCTGTTAGATAATTGAGATCACCTAGAAATGCGTTTAATCTGTTCACTCACTGTAAATTTTGAGGACCCAGAATTGTCTTGTTTA
ATTTATACTTTCACCCCTGTTGCAGTTAACACCAGAGAAGGAACGTGAATGTCGAGCACAGCCACTACCCTTGTTGGCACTTAATTTAGA
AATAGGGTGAGAAGTTTAAAAGCCCATCTTGATTTTATTTTCATTCCTTTTGGTTCTCTGTGTAATAATAGCAGGCTACATAGTGACATT
CCAGTTCCAAGAAGGTACATCCTGTCCATTCATTAATTGCTTTGATTACTAGGAGGGTTTCTGTTCAGTTTTGTTTTTAAATGTCTTGCT
GATCTAGTTCTTTCAGATGGAATAACCTTCCAGTCCCTTAGAGAGTGGAACTAGTCCATATAACCCAGCTTCAGTAGCAAAAGTAGAAGC
CGCCACATCTTTTCATTTCTCCAAGAGGAGAGTGGGGAAGGTTCCCATGACCAGCTGGGCAGTCAGGATTTCTCTAGGCATTCTAATGTG
AAATAAGTGTAGACTGCTGTCAAGGAGGCTTCATCAGAAGATGTATAGCATTTGAATGTCTAATGATAATGCATATCATTAGAATCCAAG
CTTTGAAAATTTCTGATTAATGCTCATGTATTTCTTTATCTTTGTTTTTCCTTGTGAAGAAAGACTTTCACCACTGTCTGAGTGATGATG
CTGTTGATAAGGATGATGTCGATGACTACTATATTGCATCTCTCAGGAACAGCTGATGGGAAGGGAGGGGCTGCTGAGTTCCCTTGTTCT
AGCTAGCAGCACGCTCCTCAGAGAGGGGGCCGAGTTACAGACAGCAGCCGCATTCTCATGCAAAATTAGTTTTAAACTGCTAGTGTGGGC
ATCGGTACCTTTTGCCTGGGTGATACCGAAGAATTGTTGAGGATTTAGTATGCTCCGTAGAGACAGTTCAGCCAGTCATTTCTGCATTGG
AGAGACTTCTCATACTTTCTTTGAAGACTCATAGAAAGCTGGATCTAGAGCTTTTGAATCCTTAATTAGCACAGTAGAAATTAGCTTTCT
ATGGGAATGCTTTAGTGTTAGCAGTTGACAATTAGGCCCATATTCAATCTGAATGGGAACAAAAGTAAATGCAATGATAATATACTGCTA
GTTAGAGAAACATGTTAGTTGATTATACCTGAAATGGATTATTTATCTCATCAGCAAGTATTATTTGAATAAAATGAGAAATGCTTAAGA
AAAATTGTTGCTCTACAGTAATTTGGTTTCGAAGAATGGAATGGTAACTATTTTTTCCCATCGTTCTTTTGAGAGAAGGAAGTGTGATGA
CTGATGATCTTGAAAAGCCCATTTCTGATTGCACGTTGACTGGAATTCTTTCTTTGTGTCTGTGGACTAGCGATGCTGTTTGTAAAATGA
AGATTCGGGACTGGCTCATATCTTTTTATCTAACTAGATGTCAGATCTTGAAATCTGTATTCTCGAAGCAATTCTGCCACTTGATCGTAT
TCACAGGGGCCCTGGTAGGCTCCTTTAGAAGGACCATTTCTGTTCCTAGAGCTTAACTAGAATTCATTCTTCACTGAAAAAAAAAAAAGT
TACTTAAGAAAGCATTTCTTTCCTAATCTCACTCAAATCTGCAGAATTATTTGTAATTAGTAATACAAAATCTGGCCAAAAGGAGACTTG
TAAATAGCGTAAAGTGGTGTCTTATGCTAAACGGTGGAATGTATAGGCAGAGAAGCTCTTTGAAGTTGTCAGATGAGCTGGGCTCACAAG
CCTGATTCAAACAGGCTGTCGGTCTCCTCTCACCCCTTAATACTGTGCAGCCCAAACTCCTAGGACTCTTGAACATCTGAGCAGTTTTGT
GCTTTGAGCCACTTTTTGACAAAAATGGCTCCATTTTTCCACAGCGTGGTTTTCTTAAAATAGTTTAATGTTTTATAGTCTCATAGTAGT
AGTGTTGCTTTCTAAGCTATAACAGTCGACTTTATTCTTCTACTCTGAAAAATCTTGACTTGTTTGAGTGTATATAATATATATAAAGGG
AGCCTTAATGGATTGGTTTTCATAATTTAATATTTTTTGTATTTGCTCTTGTATAATTGTTTTTAACGGAAAGTATTAAAGAATTGAGGG

>98963_98963_1_WDR37-FAM107B_WDR37_chr10_1142186_ENST00000263150_FAM107B_chr10_14709690_ENST00000181796_length(amino acids)=411AA_BP=242
MPTESASCSTARQTKQKRKSHSLSIRRTNSSEQERTGLPRDMLEGQDSKLPSSVRSTLLELFGQIEREFENLYIENLELRREIDTLNERL
AAEGQAIDGAELSKGQLKTKASHSTSQLSQKLKTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHT
ALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSEEEFREEPKCLELEQKMTSDSPPEDIDH
KDSYLITRSIMAEPDYIEDDNPELIRPQKLINPVKTSRNHQDLHRELLMNQKRGLAPQNKPELQKVMEKRKRDQVIKQKEEEAQKKKSDL

--------------------------------------------------------------
>98963_98963_2_WDR37-FAM107B_WDR37_chr10_1142186_ENST00000358220_FAM107B_chr10_14709690_ENST00000181796_length(transcript)=4010nt_BP=870nt
AGAACGATGGCCTTTCTGCGGTGTCTGCGACCGGGACCAAGGCGGAGCAAAGTCGCCGGGGGTGTGGGGTGTTCCACGCTATGTTGGGAG
TGTTCGCTTTCGAGCTTATTGCAGGAGTGACCAGGACACTACCTCCTAGAAGTAATGCCCACAGAAAGCGCAAGTTGTTCGACTGCTCGC
CAAACAAAACAGAAGCGCAAATCCCATAGCCTTTCTATACGAAGAACTAACAGCTCGGAGCAGGAGAGGACGGGACTGCCAAGAGACATG
TTAGAAGGACAAGATTCTAAACTGCCTTCCTCGGTTCGCAGTACACTTCTGGAACTGTTTGGTCAAATAGAAAGAGAATTTGAAAACCTT
TATATCGAAAACTTAGAATTACGTAGAGAAATCGACACTCTTAATGAACGTTTAGCTGCTGAAGGACAAGCGATTGATGGAGCAGAGCTG
AGTAAGGGCCAACTCAAAACAAAAGCCAGTCACAGCACCAGCCAGCTCTCCCAGAAACTGAAGACCACTTACAAGGCTTCCACCAGCAAG
ATTGTCTCCAGCTTTAAGACCACGACATCGAGAGCTGCCTGCCAGCTCGTGAAGGAGTACATCGGCCACCGGGACGGCATCTGGGATGTC
AGCGTGGCCAAGACACAGCCAGTGGTGCTCGGGACTGCATCAGCCGATCACACGGCTTTGCTGTGGAGCATAGAGACAGGGAAGTGCCTA
GTCAAGTACGCAGGCCACGTGGGCTCAGTAAATTCTATCAAATTTCATCCCTCAGAGCAGTTGGCTCTCACTGCTTCTGGAGATCAGACT
GCTCATATCTGGAGATACGCGGTGCAGCTGCCGACACCCCAGCCTGTTGCTGACACTAGTGAAGAAGAATTTCGAGAAGAACCTAAATGC
CTCGAGCTGGAGCAGAAAATGACATCAGACAGCCCACCTGAGGATATTGACCATAAGGACTCATATCTCATTACAAGAAGCATCATGGCC
GAGCCAGACTACATAGAAGATGACAATCCTGAACTCATTAGGCCTCAGAAACTGATCAATCCTGTAAAAACCTCCCGGAACCATCAAGAT
CTTCACAGAGAACTTCTTATGAATCAAAAAAGGGGTCTTGCTCCTCAGAACAAACCAGAATTGCAGAAGGTGATGGAAAAAAGAAAACGA
GACCAAGTAATAAAGCAGAAGGAAGAAGAAGCACAGAAGAAGAAATCTGACTTGGAAATAGAGCTATTAAAACGGCAGCAGAAGTTGGAG
CAGCTTGAACTTGAGAAGCAGAAATTGCAAGAAGAGCAAGAAAATGCCCCCGAGTTTGTGAAGGTGAAAGGCAATCTCAGGAGAACAGGC
CAAGAAGTCGCCCAAGCCCAGGAGTCCTAGGCTGAGGCTGCACCAAGACCTCGTGTGTCACCCCACAGAGCTGTCTGTGGGTGCCTTCTC
AATCTCAGGGCAAAAGCCCCTGGAGAATATTTCAGCCAGCAGAGAATTTTGACTTGCAGTAGGATTTGGTTTGATTTTCCTACGATCTGG
GTGGATGCCTTGCCTGTGACAGTTGCAGTTCCTATTCGCCAAATGAAGGGCAGTGCCCCGCACGTAAGTTGGAATGATGGACCTGTGTTC
AGAGACTTAACAGAACCAACAAGCAAAACAAGTGAGAACAGGAAAAAGGAAGAGGACACTGGAATCAATTCTTGAGAGTTGCACTACTTG
GTTTTTCTTCCATTCCAAGTTTCGTGGGACCCAGAGCCTTTTTTCTTTTAAAAGCTAAAAAACAAGTGTTTAATTCCTCTTTTTGTTATC
TGTTAGATAATTGAGATCACCTAGAAATGCGTTTAATCTGTTCACTCACTGTAAATTTTGAGGACCCAGAATTGTCTTGTTTAATTTATA
CTTTCACCCCTGTTGCAGTTAACACCAGAGAAGGAACGTGAATGTCGAGCACAGCCACTACCCTTGTTGGCACTTAATTTAGAAATAGGG
TGAGAAGTTTAAAAGCCCATCTTGATTTTATTTTCATTCCTTTTGGTTCTCTGTGTAATAATAGCAGGCTACATAGTGACATTCCAGTTC
CAAGAAGGTACATCCTGTCCATTCATTAATTGCTTTGATTACTAGGAGGGTTTCTGTTCAGTTTTGTTTTTAAATGTCTTGCTGATCTAG
TTCTTTCAGATGGAATAACCTTCCAGTCCCTTAGAGAGTGGAACTAGTCCATATAACCCAGCTTCAGTAGCAAAAGTAGAAGCCGCCACA
TCTTTTCATTTCTCCAAGAGGAGAGTGGGGAAGGTTCCCATGACCAGCTGGGCAGTCAGGATTTCTCTAGGCATTCTAATGTGAAATAAG
TGTAGACTGCTGTCAAGGAGGCTTCATCAGAAGATGTATAGCATTTGAATGTCTAATGATAATGCATATCATTAGAATCCAAGCTTTGAA
AATTTCTGATTAATGCTCATGTATTTCTTTATCTTTGTTTTTCCTTGTGAAGAAAGACTTTCACCACTGTCTGAGTGATGATGCTGTTGA
TAAGGATGATGTCGATGACTACTATATTGCATCTCTCAGGAACAGCTGATGGGAAGGGAGGGGCTGCTGAGTTCCCTTGTTCTAGCTAGC
AGCACGCTCCTCAGAGAGGGGGCCGAGTTACAGACAGCAGCCGCATTCTCATGCAAAATTAGTTTTAAACTGCTAGTGTGGGCATCGGTA
CCTTTTGCCTGGGTGATACCGAAGAATTGTTGAGGATTTAGTATGCTCCGTAGAGACAGTTCAGCCAGTCATTTCTGCATTGGAGAGACT
TCTCATACTTTCTTTGAAGACTCATAGAAAGCTGGATCTAGAGCTTTTGAATCCTTAATTAGCACAGTAGAAATTAGCTTTCTATGGGAA
TGCTTTAGTGTTAGCAGTTGACAATTAGGCCCATATTCAATCTGAATGGGAACAAAAGTAAATGCAATGATAATATACTGCTAGTTAGAG
AAACATGTTAGTTGATTATACCTGAAATGGATTATTTATCTCATCAGCAAGTATTATTTGAATAAAATGAGAAATGCTTAAGAAAAATTG
TTGCTCTACAGTAATTTGGTTTCGAAGAATGGAATGGTAACTATTTTTTCCCATCGTTCTTTTGAGAGAAGGAAGTGTGATGACTGATGA
TCTTGAAAAGCCCATTTCTGATTGCACGTTGACTGGAATTCTTTCTTTGTGTCTGTGGACTAGCGATGCTGTTTGTAAAATGAAGATTCG
GGACTGGCTCATATCTTTTTATCTAACTAGATGTCAGATCTTGAAATCTGTATTCTCGAAGCAATTCTGCCACTTGATCGTATTCACAGG
GGCCCTGGTAGGCTCCTTTAGAAGGACCATTTCTGTTCCTAGAGCTTAACTAGAATTCATTCTTCACTGAAAAAAAAAAAAGTTACTTAA
GAAAGCATTTCTTTCCTAATCTCACTCAAATCTGCAGAATTATTTGTAATTAGTAATACAAAATCTGGCCAAAAGGAGACTTGTAAATAG
CGTAAAGTGGTGTCTTATGCTAAACGGTGGAATGTATAGGCAGAGAAGCTCTTTGAAGTTGTCAGATGAGCTGGGCTCACAAGCCTGATT
CAAACAGGCTGTCGGTCTCCTCTCACCCCTTAATACTGTGCAGCCCAAACTCCTAGGACTCTTGAACATCTGAGCAGTTTTGTGCTTTGA
GCCACTTTTTGACAAAAATGGCTCCATTTTTCCACAGCGTGGTTTTCTTAAAATAGTTTAATGTTTTATAGTCTCATAGTAGTAGTGTTG
CTTTCTAAGCTATAACAGTCGACTTTATTCTTCTACTCTGAAAAATCTTGACTTGTTTGAGTGTATATAATATATATAAAGGGAGCCTTA
ATGGATTGGTTTTCATAATTTAATATTTTTTGTATTTGCTCTTGTATAATTGTTTTTAACGGAAAGTATTAAAGAATTGAGGGTGGAATT

>98963_98963_2_WDR37-FAM107B_WDR37_chr10_1142186_ENST00000358220_FAM107B_chr10_14709690_ENST00000181796_length(amino acids)=411AA_BP=242
MPTESASCSTARQTKQKRKSHSLSIRRTNSSEQERTGLPRDMLEGQDSKLPSSVRSTLLELFGQIEREFENLYIENLELRREIDTLNERL
AAEGQAIDGAELSKGQLKTKASHSTSQLSQKLKTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHT
ALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSEEEFREEPKCLELEQKMTSDSPPEDIDH
KDSYLITRSIMAEPDYIEDDNPELIRPQKLINPVKTSRNHQDLHRELLMNQKRGLAPQNKPELQKVMEKRKRDQVIKQKEEEAQKKKSDL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for WDR37-FAM107B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for WDR37-FAM107B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for WDR37-FAM107B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource