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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WDR48-HERC2 (FusionGDB2 ID:99012)

Fusion Gene Summary for WDR48-HERC2

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR48-HERC2
Fusion gene ID: 99012
HgeneTgene
Gene symbol

WDR48

HERC2

Gene ID

57599

8924

Gene nameWD repeat domain 48HECT and RLD domain containing E3 ubiquitin protein ligase 2
SynonymsP80|SPG60|UAF1D15F37S1|MRT38|SHEP1|jdf2|p528
Cytomap

3p22.2

15q13.1

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 48USP1 associated factor 1WD repeat endosomal proteintesticular tissue protein Li 224E3 ubiquitin-protein ligase HERC2HECT-type E3 ubiquitin transferase HERC2hect domain and RCC1-like domain-containing protein 2hect domain and RLD 2probable E3 ubiquitin-protein ligase HERC2
Modification date2020031320200313
UniProtAcc.

O95714

Ensembl transtripts involved in fusion geneENST00000302313, ENST00000544962, 
ENST00000396258, ENST00000418020, 
ENST00000466405, 
ENST00000563945, 
ENST00000261609, 
Fusion gene scores* DoF score5 X 4 X 2=407 X 8 X 4=224
# samples 58
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR48 [Title/Abstract] AND HERC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDR48(39093564)-HERC2(28397976), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWDR48

GO:0016579

protein deubiquitination

18082604|19075014|24145035

TgeneHERC2

GO:0006974

cellular response to DNA damage stimulus

22508508

TgeneHERC2

GO:0016567

protein ubiquitination

20304803


check buttonFusion gene breakpoints across WDR48 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HERC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-AAMG-01AWDR48chr3

39093564

+HERC2chr15

28397976

-
ChimerDB4BLCATCGA-XF-AAMGWDR48chr3

39093564

+HERC2chr15

28397976

-


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Fusion Gene ORF analysis for WDR48-HERC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000302313ENST00000563945WDR48chr3

39093564

+HERC2chr15

28397976

-
5CDS-intronENST00000544962ENST00000563945WDR48chr3

39093564

+HERC2chr15

28397976

-
5UTR-3CDSENST00000396258ENST00000261609WDR48chr3

39093564

+HERC2chr15

28397976

-
5UTR-3CDSENST00000418020ENST00000261609WDR48chr3

39093564

+HERC2chr15

28397976

-
5UTR-intronENST00000396258ENST00000563945WDR48chr3

39093564

+HERC2chr15

28397976

-
5UTR-intronENST00000418020ENST00000563945WDR48chr3

39093564

+HERC2chr15

28397976

-
In-frameENST00000302313ENST00000261609WDR48chr3

39093564

+HERC2chr15

28397976

-
In-frameENST00000544962ENST00000261609WDR48chr3

39093564

+HERC2chr15

28397976

-
intron-3CDSENST00000466405ENST00000261609WDR48chr3

39093564

+HERC2chr15

28397976

-
intron-intronENST00000466405ENST00000563945WDR48chr3

39093564

+HERC2chr15

28397976

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000302313WDR48chr339093564+ENST00000261609HERC2chr1528397976-4558762838341268
ENST00000544962WDR48chr339093564+ENST00000261609HERC2chr1528397976-4540581038161268

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000302313ENST00000261609WDR48chr339093564+HERC2chr1528397976-0.0007169210.99928313
ENST00000544962ENST00000261609WDR48chr339093564+HERC2chr1528397976-0.0007215620.9992785

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Fusion Genomic Features for WDR48-HERC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WDR48-HERC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:39093564/chr15:28397976)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HERC2

O95714

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:26692333}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968934457_479435824835.0DomainHECT
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968933951_400235824835.0RepeatRCC1 3-1
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968934004_405635824835.0RepeatRCC1 3-2
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968934058_410835824835.0RepeatRCC1 3-3
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968934110_416235824835.0RepeatRCC1 3-4
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968934164_421435824835.0RepeatRCC1 3-5
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968934216_426635824835.0RepeatRCC1 3-6
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968934268_431835824835.0RepeatRCC1 3-7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+119115_15416678.0RepeatNote=WD 3
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+119166_20516678.0RepeatNote=WD 4
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+119208_24716678.0RepeatNote=WD 5
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+119250_28916678.0RepeatNote=WD 6
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+11928_6716678.0RepeatNote=WD 1
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+119292_33416678.0RepeatNote=WD 7
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+119358_39716678.0RepeatNote=WD 8
HgeneWDR48chr3:39093564chr15:28397976ENST00000302313+11973_11216678.0RepeatNote=WD 2
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+118115_1540596.0RepeatNote=WD 3
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+118166_2050596.0RepeatNote=WD 4
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+118208_2470596.0RepeatNote=WD 5
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+118250_2890596.0RepeatNote=WD 6
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+11828_670596.0RepeatNote=WD 1
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+118292_3340596.0RepeatNote=WD 7
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+118358_3970596.0RepeatNote=WD 8
HgeneWDR48chr3:39093564chr15:28397976ENST00000396258+11873_1120596.0RepeatNote=WD 2
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+111115_15416403.0RepeatNote=WD 3
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+111166_20516403.0RepeatNote=WD 4
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+111208_24716403.0RepeatNote=WD 5
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+111250_28916403.0RepeatNote=WD 6
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+11128_6716403.0RepeatNote=WD 1
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+111292_33416403.0RepeatNote=WD 7
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+111358_39716403.0RepeatNote=WD 8
HgeneWDR48chr3:39093564chr15:28397976ENST00000544962+11173_11216403.0RepeatNote=WD 2
TgeneHERC2chr3:39093564chr15:28397976ENST000002616096893948_98035824835.0Coiled coilOntology_term=ECO:0000255
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968931207_128335824835.0DomainCytochrome b5 heme-binding
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968931859_193235824835.0DomainMIB/HERC2
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968932759_293635824835.0DomainDOC
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968932958_300935824835.0RepeatRCC1 2-1
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968933010_306435824835.0RepeatRCC1 2-2
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968933065_311635824835.0RepeatRCC1 2-3
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968933118_316835824835.0RepeatRCC1 2-4
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968933171_322235824835.0RepeatRCC1 2-5
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968933224_327435824835.0RepeatRCC1 2-6
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968933275_332635824835.0RepeatRCC1 2-7
TgeneHERC2chr3:39093564chr15:28397976ENST000002616096893415_46135824835.0RepeatRCC1 1-1
TgeneHERC2chr3:39093564chr15:28397976ENST000002616096893462_51235824835.0RepeatRCC1 1-2
TgeneHERC2chr3:39093564chr15:28397976ENST000002616096893513_56835824835.0RepeatRCC1 1-3
TgeneHERC2chr3:39093564chr15:28397976ENST000002616096893569_62035824835.0RepeatRCC1 1-4
TgeneHERC2chr3:39093564chr15:28397976ENST000002616096893623_67435824835.0RepeatRCC1 1-5
TgeneHERC2chr3:39093564chr15:28397976ENST000002616096893675_72635824835.0RepeatRCC1 1-6
TgeneHERC2chr3:39093564chr15:28397976ENST000002616096893728_77835824835.0RepeatRCC1 1-7
TgeneHERC2chr3:39093564chr15:28397976ENST0000026160968932702_274935824835.0Zinc fingerZZ-type


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Fusion Gene Sequence for WDR48-HERC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99012_99012_1_WDR48-HERC2_WDR48_chr3_39093564_ENST00000302313_HERC2_chr15_28397976_ENST00000261609_length(transcript)=4558nt_BP=76nt
AAGTGACGTCGGAGTGTCAACATGCAAGATGGCGGCCCATCACCGGCAGAACACAGCAGGGCGGAGGAAAGTGCAGGTGGCAGATATGCT
GTTGGAGCTCTGTGTCACCGAGTTGGAGGATGTGGCCACAGACTCGCAGAGCGGCCGCCTCTCTTCTCAGCCTGTGGTGGTGGAGAGTAG
CCACCCTTACACCGACGACACCTCCACCAGTGGCACAGTGAAGATACCAGGTGCAGAAGGACTCAGGGTAGAATTTGACCGGCAGTGCTC
CACAGAGAGGCGCCACGACCCTCTCACAGTCATGGACGGCGTCAACAGGATCGTCTCCGTGCGGTCAGGCCGAGAGTGGTCCGACTGGTC
CAGCGAGCTGCGCATCCCAGGGGATGAGTTAAAGTGGAAGTTCATCAGCGATGGGTCTGTGAATGGCTGGGGCTGGCGCTTCACCGTCTA
TCCCATCATGCCAGCTGCTGGCCCTAAAGAACTCCTCTCTGACCGCTGCGTCCTCTCCTGTCCATCCATGGACTTGGTGACGTGTCTGTT
AGACTTCCGACTCAACCTTGCCTCTAACAGAAGCATCGTCCCTCGCCTTGCGGCCTCGCTGGCAGCTTGTGCACAGCTGAGTGCCCTAGC
TGCCAGTCACAGAATGTGGGCCCTTCAGAGACTGAGGAAGCTGCTTACAACTGAATTTGGGCAGTCAATTAACATAAATAGGCTGCTTGG
AGAAAATGATGGGGAAACAAGAGCTTTGAGTTTTACAGGTAGTGCTCTTGCTGCTTTGGTGAAAGGTCTTCCAGAAGCTTTGCAAAGGCA
GTTTGAATATGAAGATCCTATTGTGAGGGGTGGCAAACAGCTGCTCCACAGCCCATTCTTTAAGGTACTGGTAGCTCTTGCTTGTGACCT
GGAGCTGGACACTCTGCCTTGCTGTGCCGAGACGCACAAGTGGGCCTGGTTCCGGAGGTACTGCATGGCCTCCCGTGTTGCTGTGGCCCT
TGACAAAAGAACACCGTTGCCCCGTCTGTTTCTTGATGAGGTGGCTAAGAAAATTCGTGAATTAATGGCAGACAGCGAAAACATGGATGT
TCTGCATGAGAGCCATGACATTTTTAAAAGAGAGCAAGACGAACAACTTGTGCAGTGGATGAACAGGCGACCAGATGACTGGACTCTCTC
TGCTGGTGGCAGTGGAACAATTTATGGATGGGGACATAATCACAGGGGCCAGCTCGGGGGCATTGAAGGCGCAAAAGTCAAAGTTCCCAC
TCCCTGTGAAGCCCTTGCAACTCTCAGACCCGTGCAGTTAATCGGAGGGGAACAGACCCTCTTTGCTGTGACGGCTGATGGGAAGCTGTA
TGCCACTGGGTATGGTGCAGGTGGCAGACTAGGCATTGGAGGGACAGAGTCGGTGTCCACCCCAACATTGCTTGAATCCATTCAGCATGT
GTTTATTAAGAAAGTAGCTGTGAACTCTGGAGGAAAGCACTGCCTTGCCCTGTCTTCAGAAGGAGAAGTTTACTCTTGGGGTGAGGCAGA
AGATGGGAAGTTGGGGCATGGCAACAGAAGTCCGTGTGACCGCCCTCGTGTCATCGAGTCTCTGAGAGGAATTGAAGTGGTCGATGTTGC
TGCTGGCGGAGCCCACAGCGCCTGTGTCACAGCAGCCGGGGACCTCTACACATGGGGCAAAGGCCGCTACGGCCGGCTGGGGCACAGCGA
CAGTGAGGACCAGCTGAAGCCGAAGCTGGTGGAGGCGCTGCAGGGCCACCGTGTGGTTGACATCGCCTGTGGCAGTGGAGATGCCCAGAC
CCTCTGCCTCACAGATGACGACACTGTCTGGTCCTGGGGGGACGGGGACTACGGCAAGCTCGGCCGGGGAGGCAGCGATGGCTGTAAAGT
GCCTATGAAGATTGATTCTCTTACTGGTCTTGGAGTAGTTAAAGTGGAATGCGGATCCCAGTTTTCTGTTGCCCTTACCAAATCTGGAGC
TGTTTATACCTGGGGCAAAGGCGATTATCACAGGTTGGGCCATGGATCAGATGACCATGTTCGAAGGCCTCGGCAGGTCCAAGGGTTGCA
GGGGAAGAAAGTCATCGCCATCGCCACTGGCTCCCTGCACTGTGTGTGCTGCACAGAGGATGGTGAGGTTTATACATGGGGCGACAATGA
TGAGGGACAACTGGGAGACGGAACCACCAATGCCATCCAGAGGCCTCGGTTGGTAGCTGCCCTTCAGGGTAAGAAGGTCAACCGTGTGGC
CTGTGGCTCAGCACATACCCTCGCCTGGTCGACCAGCAAGCCCGCCAGTGCTGGCAAACTCCCTGCACAGGTCCCCATGGAGTACAATCA
CCTGCAGGAGATCCCCATCATTGCGCTGAGGAACCGTCTGCTGCTGCTGCACCACCTCTCCGAGCTCTTCTGCCCCTGCATCCCCATGTT
CGACCTGGAAGGCTCGCTCGACGAAACTGGACTCGGGCCTTCTGTTGGGTTCGACACTCTCCGAGGAATTCTGATATCCCAGGGAAAGGA
GGCGGCTTTCCGGAAAGTAGTACAAGCAACTATGGTACGCGATCGTCAGCATGGCCCCGTCGTGGAGCTGAACCGCATCCAGGTCAAACG
ATCAAGGAGCAAAGGCGGGCTGGCCGGCCCCGACGGCACCAAGTCTGTCTTTGGGCAGATGTGTGCTAAGATGAGCTCGTTTGGTCCCGA
CAGCCTCCTCCTTCCTCACCGTGTCTGGAAAGTCAAGTTTGTGGGTGAATCTGTGGATGACTGTGGGGGCGGCTACAGCGAGTCCATAGC
TGAGATCTGTGAGGAGCTGCAGAACGGACTCACGCCCCTGCTGATCGTGACACCCAACGGGAGGGATGAGTCTGGGGCCAACCGAGACTG
CTACCTGCTCAGCCCGGCCGCCAGAGCACCCGTGCACAGCAGCATGTTCCGCTTCCTGGGTGTGTTGCTGGGCATTGCCATCCGAACCGG
GAGTCCCCTGAGCCTCAACCTTGCCGAGCCTGTCTGGAAGCAGCTGGCTGGGATGAGCCTCACCATCGCGGACCTCAGTGAGGTTGATAA
GGATTTTATTCCTGGACTCATGTACATCCGAGACAATGAAGCCACCTCAGAGGAGTTTGAAGCCATGAGCCTGCCCTTCACAGTGCCAAG
TGCCAGTGGCCAGGACATTCAGTTGAGCTCCAAGCACACACACATCACCCTGGACAACCGCGCGGAGTACGTGCGGCTGGCGATAAACTA
TAGACTCCATGAATTTGATGAGCAGGTGGCTGCTGTTCGGGAAGGAATGGCCCGCGTTGTGCCTGTTCCCCTCCTCTCTCTGTTCACCGG
CTACGAACTGGAGACGATGGTGTGTGGCAGCCCTGACATCCCGCTGCACCTTCTCAAGTCGGTGGCCACCTATAAAGGCATCGAGCCTTC
CGCATCGCTGATCCAGTGGTTCTGGGAGGTGATGGAGTCCTTCTCCAACACAGAGCGCTCTCTTTTCCTTCGCTTCGTCTGGGGCCGGAC
GAGGCTGCCCAGGACCATCGCCGACTTCCGGGGCCGAGACTTCGTCATCCAGGTGTTGGATAAATACAACCCTCCAGACCACTTCCTCCC
TGAGTCCTACACCTGTTTCTTCTTGCTGAAGCTGCCCAGGTATTCCTGCAAGCAGGTGCTGGAGGAGAAGCTCAAGTACGCCATCCACTT
CTGCAAGTCCATAGACACAGATGACTACGCTCGCATCGCACTTACAGGAGAGCCAGCCGCCGACGACAGCAGCGACGATTCAGATAACGA
GGATGTCGACTCCTTTGCTTCGGACTCTACACAAGATTATTTAACAGGACACTAAGATGGGGAAACGTCCTCGTGAGATGAGAGCCTGAG
CCAGGCAGCAGAGCGCTCGCTGCTGTGTAGACTGTAGGCTGCCTGGTGTGTCTGATGAGAAGCGTCCGTCCTCGAGCCAGGCGGGAGGAG
GGAGTGGAGAGACTGACTGGCCGTGATGGGAATGACAGTGAGAAGGTCCGCCTGTGCGCGTGGAACACTGTGGACGCTCGACTTCCAAGG
GTCTTCTCACCCGTAATGCTGCATTACATGTAGGACTGTGTTTACTAAAGTGTGTAAATGTTTATATAAATACCAAATTGCAGCATCCCC
AAAATGAATAAAGCCTTTTTACTTGTGGGTGCAATCGATTTTTTTTCTTTCTCCTTTCTTTCAAGTGTCGTGAGTCGTCTTGATTGTATA
TTGGAAATAACTGTGTAACAAATCGTATTATAAATATTTCAATTAATTTTACTCTGAATTTGTTTATTAAAAGACTTTTGAACATGAAAT
GATTAGTATTACTTGAATGCATCCAGAGGATATTTAAACCAAAATGAAAAACCAGAAGGCCATTTGGTGTCCCCCCTCCCAGGTGTCCCC
TTGTAGCATATGCATTATGTCATCTGAATTGAGGCCTTTCTGTGAACAGCATCATAACTTCTATCATGGAAAGTGTACTATATATAATGT

>99012_99012_1_WDR48-HERC2_WDR48_chr3_39093564_ENST00000302313_HERC2_chr15_28397976_ENST00000261609_length(amino acids)=1268AA_BP=599
MAAHHRQNTAGRRKVQVADMLLELCVTELEDVATDSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLT
VMDGVNRIVSVRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLSDRCVLSCPSMDLVTCLLDFRLNLASN
RSIVPRLAASLAACAQLSALAASHRMWALQRLRKLLTTEFGQSININRLLGENDGETRALSFTGSALAALVKGLPEALQRQFEYEDPIVR
GGKQLLHSPFFKVLVALACDLELDTLPCCAETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSENMDVLHESHDIFK
REQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGR
LGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACV
TAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTG
LGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTT
NAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDLEGSLDET
GLGPSVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFGPDSLLLPHRVW
KVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAE
PVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQV
AAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADF
RGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIALTGEPAADDSSDDSDNEDVDSFASDS

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>99012_99012_2_WDR48-HERC2_WDR48_chr3_39093564_ENST00000544962_HERC2_chr15_28397976_ENST00000261609_length(transcript)=4540nt_BP=58nt
AACATGCAAGATGGCGGCCCATCACCGGCAGAACACAGCAGGGCGGAGGAAAGTGCAGGTGGCAGATATGCTGTTGGAGCTCTGTGTCAC
CGAGTTGGAGGATGTGGCCACAGACTCGCAGAGCGGCCGCCTCTCTTCTCAGCCTGTGGTGGTGGAGAGTAGCCACCCTTACACCGACGA
CACCTCCACCAGTGGCACAGTGAAGATACCAGGTGCAGAAGGACTCAGGGTAGAATTTGACCGGCAGTGCTCCACAGAGAGGCGCCACGA
CCCTCTCACAGTCATGGACGGCGTCAACAGGATCGTCTCCGTGCGGTCAGGCCGAGAGTGGTCCGACTGGTCCAGCGAGCTGCGCATCCC
AGGGGATGAGTTAAAGTGGAAGTTCATCAGCGATGGGTCTGTGAATGGCTGGGGCTGGCGCTTCACCGTCTATCCCATCATGCCAGCTGC
TGGCCCTAAAGAACTCCTCTCTGACCGCTGCGTCCTCTCCTGTCCATCCATGGACTTGGTGACGTGTCTGTTAGACTTCCGACTCAACCT
TGCCTCTAACAGAAGCATCGTCCCTCGCCTTGCGGCCTCGCTGGCAGCTTGTGCACAGCTGAGTGCCCTAGCTGCCAGTCACAGAATGTG
GGCCCTTCAGAGACTGAGGAAGCTGCTTACAACTGAATTTGGGCAGTCAATTAACATAAATAGGCTGCTTGGAGAAAATGATGGGGAAAC
AAGAGCTTTGAGTTTTACAGGTAGTGCTCTTGCTGCTTTGGTGAAAGGTCTTCCAGAAGCTTTGCAAAGGCAGTTTGAATATGAAGATCC
TATTGTGAGGGGTGGCAAACAGCTGCTCCACAGCCCATTCTTTAAGGTACTGGTAGCTCTTGCTTGTGACCTGGAGCTGGACACTCTGCC
TTGCTGTGCCGAGACGCACAAGTGGGCCTGGTTCCGGAGGTACTGCATGGCCTCCCGTGTTGCTGTGGCCCTTGACAAAAGAACACCGTT
GCCCCGTCTGTTTCTTGATGAGGTGGCTAAGAAAATTCGTGAATTAATGGCAGACAGCGAAAACATGGATGTTCTGCATGAGAGCCATGA
CATTTTTAAAAGAGAGCAAGACGAACAACTTGTGCAGTGGATGAACAGGCGACCAGATGACTGGACTCTCTCTGCTGGTGGCAGTGGAAC
AATTTATGGATGGGGACATAATCACAGGGGCCAGCTCGGGGGCATTGAAGGCGCAAAAGTCAAAGTTCCCACTCCCTGTGAAGCCCTTGC
AACTCTCAGACCCGTGCAGTTAATCGGAGGGGAACAGACCCTCTTTGCTGTGACGGCTGATGGGAAGCTGTATGCCACTGGGTATGGTGC
AGGTGGCAGACTAGGCATTGGAGGGACAGAGTCGGTGTCCACCCCAACATTGCTTGAATCCATTCAGCATGTGTTTATTAAGAAAGTAGC
TGTGAACTCTGGAGGAAAGCACTGCCTTGCCCTGTCTTCAGAAGGAGAAGTTTACTCTTGGGGTGAGGCAGAAGATGGGAAGTTGGGGCA
TGGCAACAGAAGTCCGTGTGACCGCCCTCGTGTCATCGAGTCTCTGAGAGGAATTGAAGTGGTCGATGTTGCTGCTGGCGGAGCCCACAG
CGCCTGTGTCACAGCAGCCGGGGACCTCTACACATGGGGCAAAGGCCGCTACGGCCGGCTGGGGCACAGCGACAGTGAGGACCAGCTGAA
GCCGAAGCTGGTGGAGGCGCTGCAGGGCCACCGTGTGGTTGACATCGCCTGTGGCAGTGGAGATGCCCAGACCCTCTGCCTCACAGATGA
CGACACTGTCTGGTCCTGGGGGGACGGGGACTACGGCAAGCTCGGCCGGGGAGGCAGCGATGGCTGTAAAGTGCCTATGAAGATTGATTC
TCTTACTGGTCTTGGAGTAGTTAAAGTGGAATGCGGATCCCAGTTTTCTGTTGCCCTTACCAAATCTGGAGCTGTTTATACCTGGGGCAA
AGGCGATTATCACAGGTTGGGCCATGGATCAGATGACCATGTTCGAAGGCCTCGGCAGGTCCAAGGGTTGCAGGGGAAGAAAGTCATCGC
CATCGCCACTGGCTCCCTGCACTGTGTGTGCTGCACAGAGGATGGTGAGGTTTATACATGGGGCGACAATGATGAGGGACAACTGGGAGA
CGGAACCACCAATGCCATCCAGAGGCCTCGGTTGGTAGCTGCCCTTCAGGGTAAGAAGGTCAACCGTGTGGCCTGTGGCTCAGCACATAC
CCTCGCCTGGTCGACCAGCAAGCCCGCCAGTGCTGGCAAACTCCCTGCACAGGTCCCCATGGAGTACAATCACCTGCAGGAGATCCCCAT
CATTGCGCTGAGGAACCGTCTGCTGCTGCTGCACCACCTCTCCGAGCTCTTCTGCCCCTGCATCCCCATGTTCGACCTGGAAGGCTCGCT
CGACGAAACTGGACTCGGGCCTTCTGTTGGGTTCGACACTCTCCGAGGAATTCTGATATCCCAGGGAAAGGAGGCGGCTTTCCGGAAAGT
AGTACAAGCAACTATGGTACGCGATCGTCAGCATGGCCCCGTCGTGGAGCTGAACCGCATCCAGGTCAAACGATCAAGGAGCAAAGGCGG
GCTGGCCGGCCCCGACGGCACCAAGTCTGTCTTTGGGCAGATGTGTGCTAAGATGAGCTCGTTTGGTCCCGACAGCCTCCTCCTTCCTCA
CCGTGTCTGGAAAGTCAAGTTTGTGGGTGAATCTGTGGATGACTGTGGGGGCGGCTACAGCGAGTCCATAGCTGAGATCTGTGAGGAGCT
GCAGAACGGACTCACGCCCCTGCTGATCGTGACACCCAACGGGAGGGATGAGTCTGGGGCCAACCGAGACTGCTACCTGCTCAGCCCGGC
CGCCAGAGCACCCGTGCACAGCAGCATGTTCCGCTTCCTGGGTGTGTTGCTGGGCATTGCCATCCGAACCGGGAGTCCCCTGAGCCTCAA
CCTTGCCGAGCCTGTCTGGAAGCAGCTGGCTGGGATGAGCCTCACCATCGCGGACCTCAGTGAGGTTGATAAGGATTTTATTCCTGGACT
CATGTACATCCGAGACAATGAAGCCACCTCAGAGGAGTTTGAAGCCATGAGCCTGCCCTTCACAGTGCCAAGTGCCAGTGGCCAGGACAT
TCAGTTGAGCTCCAAGCACACACACATCACCCTGGACAACCGCGCGGAGTACGTGCGGCTGGCGATAAACTATAGACTCCATGAATTTGA
TGAGCAGGTGGCTGCTGTTCGGGAAGGAATGGCCCGCGTTGTGCCTGTTCCCCTCCTCTCTCTGTTCACCGGCTACGAACTGGAGACGAT
GGTGTGTGGCAGCCCTGACATCCCGCTGCACCTTCTCAAGTCGGTGGCCACCTATAAAGGCATCGAGCCTTCCGCATCGCTGATCCAGTG
GTTCTGGGAGGTGATGGAGTCCTTCTCCAACACAGAGCGCTCTCTTTTCCTTCGCTTCGTCTGGGGCCGGACGAGGCTGCCCAGGACCAT
CGCCGACTTCCGGGGCCGAGACTTCGTCATCCAGGTGTTGGATAAATACAACCCTCCAGACCACTTCCTCCCTGAGTCCTACACCTGTTT
CTTCTTGCTGAAGCTGCCCAGGTATTCCTGCAAGCAGGTGCTGGAGGAGAAGCTCAAGTACGCCATCCACTTCTGCAAGTCCATAGACAC
AGATGACTACGCTCGCATCGCACTTACAGGAGAGCCAGCCGCCGACGACAGCAGCGACGATTCAGATAACGAGGATGTCGACTCCTTTGC
TTCGGACTCTACACAAGATTATTTAACAGGACACTAAGATGGGGAAACGTCCTCGTGAGATGAGAGCCTGAGCCAGGCAGCAGAGCGCTC
GCTGCTGTGTAGACTGTAGGCTGCCTGGTGTGTCTGATGAGAAGCGTCCGTCCTCGAGCCAGGCGGGAGGAGGGAGTGGAGAGACTGACT
GGCCGTGATGGGAATGACAGTGAGAAGGTCCGCCTGTGCGCGTGGAACACTGTGGACGCTCGACTTCCAAGGGTCTTCTCACCCGTAATG
CTGCATTACATGTAGGACTGTGTTTACTAAAGTGTGTAAATGTTTATATAAATACCAAATTGCAGCATCCCCAAAATGAATAAAGCCTTT
TTACTTGTGGGTGCAATCGATTTTTTTTCTTTCTCCTTTCTTTCAAGTGTCGTGAGTCGTCTTGATTGTATATTGGAAATAACTGTGTAA
CAAATCGTATTATAAATATTTCAATTAATTTTACTCTGAATTTGTTTATTAAAAGACTTTTGAACATGAAATGATTAGTATTACTTGAAT
GCATCCAGAGGATATTTAAACCAAAATGAAAAACCAGAAGGCCATTTGGTGTCCCCCCTCCCAGGTGTCCCCTTGTAGCATATGCATTAT
GTCATCTGAATTGAGGCCTTTCTGTGAACAGCATCATAACTTCTATCATGGAAAGTGTACTATATATAATGTTTGTGTCATGTATATGCC

>99012_99012_2_WDR48-HERC2_WDR48_chr3_39093564_ENST00000544962_HERC2_chr15_28397976_ENST00000261609_length(amino acids)=1268AA_BP=599
MAAHHRQNTAGRRKVQVADMLLELCVTELEDVATDSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLT
VMDGVNRIVSVRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLSDRCVLSCPSMDLVTCLLDFRLNLASN
RSIVPRLAASLAACAQLSALAASHRMWALQRLRKLLTTEFGQSININRLLGENDGETRALSFTGSALAALVKGLPEALQRQFEYEDPIVR
GGKQLLHSPFFKVLVALACDLELDTLPCCAETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSENMDVLHESHDIFK
REQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGR
LGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACV
TAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTG
LGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTT
NAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDLEGSLDET
GLGPSVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFGPDSLLLPHRVW
KVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAE
PVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQV
AAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADF
RGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIALTGEPAADDSSDDSDNEDVDSFASDS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WDR48-HERC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WDR48-HERC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WDR48-HERC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource