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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WDR49-VEPH1 (FusionGDB2 ID:99017)

Fusion Gene Summary for WDR49-VEPH1

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR49-VEPH1
Fusion gene ID: 99017
HgeneTgene
Gene symbol

WDR49

VEPH1

Gene ID

151790

79674

Gene nameWD repeat domain 49ventricular zone expressed PH domain containing 1
Synonyms-MELT|VEPH
Cytomap

3q26.1

3q25.31-q25.32

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 49ventricular zone-expressed PH domain-containing protein homolog 1protein meltedventricular zone expressed PH domain homolog 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000308378, ENST00000453925, 
ENST00000476376, ENST00000479765, 
ENST00000468233, ENST00000469007, 
ENST00000494677, ENST00000537559, 
ENST00000362010, ENST00000392832, 
ENST00000392833, ENST00000543418, 
Fusion gene scores* DoF score2 X 3 X 2=126 X 5 X 5=150
# samples 28
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR49 [Title/Abstract] AND VEPH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDR49(167277852)-VEPH1(157099165), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneVEPH1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

26039994

TgeneVEPH1

GO:0060392

negative regulation of SMAD protein signal transduction

26039994


check buttonFusion gene breakpoints across WDR49 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VEPH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-7470-01AWDR49chr3

167277852

-VEPH1chr3

157099165

-
ChimerDB4LGGTCGA-HT-7470WDR49chr3

167277852

-VEPH1chr3

157099165

-


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Fusion Gene ORF analysis for WDR49-VEPH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000308378ENST00000468233WDR49chr3

167277852

-VEPH1chr3

157099165

-
5CDS-intronENST00000308378ENST00000469007WDR49chr3

167277852

-VEPH1chr3

157099165

-
5CDS-intronENST00000308378ENST00000494677WDR49chr3

167277852

-VEPH1chr3

157099165

-
5CDS-intronENST00000308378ENST00000537559WDR49chr3

167277852

-VEPH1chr3

157099165

-
5CDS-intronENST00000453925ENST00000468233WDR49chr3

167277852

-VEPH1chr3

157099165

-
5CDS-intronENST00000453925ENST00000469007WDR49chr3

167277852

-VEPH1chr3

157099165

-
5CDS-intronENST00000453925ENST00000494677WDR49chr3

167277852

-VEPH1chr3

157099165

-
5CDS-intronENST00000453925ENST00000537559WDR49chr3

167277852

-VEPH1chr3

157099165

-
5CDS-intronENST00000476376ENST00000468233WDR49chr3

167277852

-VEPH1chr3

157099165

-
5CDS-intronENST00000476376ENST00000469007WDR49chr3

167277852

-VEPH1chr3

157099165

-
5CDS-intronENST00000476376ENST00000494677WDR49chr3

167277852

-VEPH1chr3

157099165

-
5CDS-intronENST00000476376ENST00000537559WDR49chr3

167277852

-VEPH1chr3

157099165

-
Frame-shiftENST00000476376ENST00000362010WDR49chr3

167277852

-VEPH1chr3

157099165

-
Frame-shiftENST00000476376ENST00000392832WDR49chr3

167277852

-VEPH1chr3

157099165

-
Frame-shiftENST00000476376ENST00000392833WDR49chr3

167277852

-VEPH1chr3

157099165

-
Frame-shiftENST00000476376ENST00000543418WDR49chr3

167277852

-VEPH1chr3

157099165

-
In-frameENST00000308378ENST00000362010WDR49chr3

167277852

-VEPH1chr3

157099165

-
In-frameENST00000308378ENST00000392832WDR49chr3

167277852

-VEPH1chr3

157099165

-
In-frameENST00000308378ENST00000392833WDR49chr3

167277852

-VEPH1chr3

157099165

-
In-frameENST00000308378ENST00000543418WDR49chr3

167277852

-VEPH1chr3

157099165

-
In-frameENST00000453925ENST00000362010WDR49chr3

167277852

-VEPH1chr3

157099165

-
In-frameENST00000453925ENST00000392832WDR49chr3

167277852

-VEPH1chr3

157099165

-
In-frameENST00000453925ENST00000392833WDR49chr3

167277852

-VEPH1chr3

157099165

-
In-frameENST00000453925ENST00000543418WDR49chr3

167277852

-VEPH1chr3

157099165

-
intron-3CDSENST00000479765ENST00000362010WDR49chr3

167277852

-VEPH1chr3

157099165

-
intron-3CDSENST00000479765ENST00000392832WDR49chr3

167277852

-VEPH1chr3

157099165

-
intron-3CDSENST00000479765ENST00000392833WDR49chr3

167277852

-VEPH1chr3

157099165

-
intron-3CDSENST00000479765ENST00000543418WDR49chr3

167277852

-VEPH1chr3

157099165

-
intron-intronENST00000479765ENST00000468233WDR49chr3

167277852

-VEPH1chr3

157099165

-
intron-intronENST00000479765ENST00000469007WDR49chr3

167277852

-VEPH1chr3

157099165

-
intron-intronENST00000479765ENST00000494677WDR49chr3

167277852

-VEPH1chr3

157099165

-
intron-intronENST00000479765ENST00000537559WDR49chr3

167277852

-VEPH1chr3

157099165

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000308378WDR49chr3167277852-ENST00000543418VEPH1chr3157099165-38109573062417703
ENST00000308378WDR49chr3167277852-ENST00000392833VEPH1chr3157099165-38109573062417703
ENST00000308378WDR49chr3167277852-ENST00000362010VEPH1chr3157099165-39459573062552748
ENST00000308378WDR49chr3167277852-ENST00000392832VEPH1chr3157099165-27789573062552748
ENST00000453925WDR49chr3167277852-ENST00000543418VEPH1chr3157099165-3698845352305756
ENST00000453925WDR49chr3167277852-ENST00000392833VEPH1chr3157099165-3698845352305756
ENST00000453925WDR49chr3167277852-ENST00000362010VEPH1chr3157099165-3833845352440801
ENST00000453925WDR49chr3167277852-ENST00000392832VEPH1chr3157099165-2666845352440801

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308378ENST00000543418WDR49chr3167277852-VEPH1chr3157099165-0.0013746710.9986254
ENST00000308378ENST00000392833WDR49chr3167277852-VEPH1chr3157099165-0.0013746710.9986254
ENST00000308378ENST00000362010WDR49chr3167277852-VEPH1chr3157099165-0.0011843420.99881566
ENST00000308378ENST00000392832WDR49chr3167277852-VEPH1chr3157099165-0.0022783410.9977216
ENST00000453925ENST00000543418WDR49chr3167277852-VEPH1chr3157099165-0.0005302720.9994697
ENST00000453925ENST00000392833WDR49chr3167277852-VEPH1chr3157099165-0.0005302720.9994697
ENST00000453925ENST00000362010WDR49chr3167277852-VEPH1chr3157099165-0.0005266770.9994734
ENST00000453925ENST00000392832WDR49chr3167277852-VEPH1chr3157099165-0.001303950.998696

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Fusion Genomic Features for WDR49-VEPH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WDR49-VEPH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:167277852/chr3:157099165)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR49chr3:167277852chr3:157099165ENST00000308378-515146_187217698.0RepeatNote=WD 3
HgeneWDR49chr3:167277852chr3:157099165ENST00000308378-51517_56217698.0RepeatNote=WD 1
HgeneWDR49chr3:167277852chr3:157099165ENST00000308378-51560_99217698.0RepeatNote=WD 2
TgeneVEPH1chr3:167277852chr3:157099165ENST00000362010514716_819302834.0DomainPH
TgeneVEPH1chr3:167277852chr3:157099165ENST00000392832514716_819302834.0DomainPH
TgeneVEPH1chr3:167277852chr3:157099165ENST00000392833513716_819302789.0DomainPH
TgeneVEPH1chr3:167277852chr3:157099165ENST0000046823304716_8190214.0DomainPH
TgeneVEPH1chr3:167277852chr3:157099165ENST0000049467705716_8190214.0DomainPH
TgeneVEPH1chr3:167277852chr3:157099165ENST0000053755904716_8190178.0DomainPH
TgeneVEPH1chr3:167277852chr3:157099165ENST00000543418513716_819302789.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR49chr3:167277852chr3:157099165ENST00000308378-515190_229217698.0RepeatNote=WD 4
HgeneWDR49chr3:167277852chr3:157099165ENST00000308378-515281_319217698.0RepeatNote=WD 5
HgeneWDR49chr3:167277852chr3:157099165ENST00000308378-515367_414217698.0RepeatNote=WD 6
HgeneWDR49chr3:167277852chr3:157099165ENST00000308378-515417_457217698.0RepeatNote=WD 7
HgeneWDR49chr3:167277852chr3:157099165ENST00000308378-515473_514217698.0RepeatNote=WD 8
HgeneWDR49chr3:167277852chr3:157099165ENST00000476376-313146_18742523.0RepeatNote=WD 3
HgeneWDR49chr3:167277852chr3:157099165ENST00000476376-31317_5642523.0RepeatNote=WD 1
HgeneWDR49chr3:167277852chr3:157099165ENST00000476376-313190_22942523.0RepeatNote=WD 4
HgeneWDR49chr3:167277852chr3:157099165ENST00000476376-313281_31942523.0RepeatNote=WD 5
HgeneWDR49chr3:167277852chr3:157099165ENST00000476376-313367_41442523.0RepeatNote=WD 6
HgeneWDR49chr3:167277852chr3:157099165ENST00000476376-313417_45742523.0RepeatNote=WD 7
HgeneWDR49chr3:167277852chr3:157099165ENST00000476376-313473_51442523.0RepeatNote=WD 8
HgeneWDR49chr3:167277852chr3:157099165ENST00000476376-31360_9942523.0RepeatNote=WD 2


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Fusion Gene Sequence for WDR49-VEPH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99017_99017_1_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000308378_VEPH1_chr3_157099165_ENST00000362010_length(transcript)=3945nt_BP=957nt
AGGCACCTGTTGAAGGAAAAAGAAGATCCATCCTTATAGAAATAGTTGAAGGCAACTGAGAAAAGGTGAAGCCATTATGAGTTGCCAGAA
AGCTGTACTTGAGTTAAACATAGGGTCACAGCTTGGGCCAAAGAGTCCTGAGAGAACAGAAGGTGTAACTGCATTTGAAGACTATGGCAC
AGGCCTGCTTGAAAACCAACTCAGCGTGGGTGACTTTGTAAAAATACAGAAGGCCTTTGAGTTACTTACAATGCATCTTTAGACGCTATC
ATTTCCAGTACAACCAGCAATACAAATAGTGTGGTGATGGCTTGGAGAGAGAAATCAAAAAAGCGTCTTAATATGACATCCTTCAACATT
GCCCAGGGCATTCATGCTTTTGATTATCACTCTCGGCTCAATTTAATTGCAACTGCTGGCATTAACAATAAAGTTTGCCTTTGGAATCCC
TATGTTGTCTCTAAACCAGTGGGTGTCCTTTGGGGCCACTCAGCCAGTGTAATAGCCGTCCAATTCTTTGTGGAAAGAAAACAACTTTTC
AGCTTCTCCAAGGATAAAGTTTTGAGACTCTGGGATATTCAACACCAGCTGTCCATCCAGAGGATAGCTTGTTCTTTCCCCAAAAGTCAG
GACTTCAGATGTCTCTTCCACTTTGATGAAGCCCATGGACGACTTTTCATCTCGTTTAATAACCAGCTAGCATTGTTGGCAATGAAAAGT
GAAGCCAGCAAGAGGGTGAAAAGCCATGAGAAAGCAGTCACTTGTGTTCTTTACAATTCTATCTTGAAGCAGGTAATCAGCTCTGATACA
GGGTCTACTGTTTCCTTCTGGATGATAGACACTGGGCAGAAAATCAAACAGTTTACTGGTTGCCACGGCAACGCAGAAATCAGCACTATG
GCCCTTGATGCAAATGAGACTCGGCTTTTGACTGGCAGCACAGATGGGACTGTAAAGGAGAGAGCCAGGAGCTGCCTGACATACCTGGTG
AGCCAACTGGCCAACATGGAGCATTCGTTTCACCATATTCTCCTGCTGGAGATTAAAAGCATCACCGACACCTTCTCCTCAATCTTGGGC
CCTCAGAGCAGAGACATCTTCCGCATGAGCAACAGCTTCACCGCCATTGCTAAACTCCTTACCCGACAACTGGAAAATACCAAGGCTGGA
AGTGGCAGGAGAAAAATCAGCACTGAAATTGAATTCCCTGAGAAACTGGAAGAAACCAAGCTCATAGTAACTGAAAATGAAGACCATGAA
AAACTCCAAGTTAAAATCCAGGCTTTTGAAGACAAGATAAATGCAGGGAGCAATACCCCTGGCTCTATCAGAAGATATAGTCTGGGCCAA
GTTTCTAAAGAAGAAAGAAAAAACATTAGATTTAACAGGTCAAAAAGTTTGGCTTTCCACACTATGCTCACAAAGGGTGTGGGTTCAGAT
GACGGCGAAGATGAAAACAGGGGAGACATACCAGCCAGCATCTCTCTTTCAGAAATAGACCCACTTGGCCAAGGAAATGACAAGCTGCCG
TTTAAGACAGACACTGAGAGATCACAGCTGGGGGAGTCTTCAGTTTCATACCCAAATATTATACATATAGACTCAGAGAATTTGTCAGAA
ACTGTTAAAGAAAACTCCCAGGAAGAAACTCCAGAGACAACTGCAAGTCCTATAGAATACCAAGATAAGCTCTACTTGCACTTAAAAAAA
AACCTCAGCAAAGTGAAAGCATATGCCATGGAAATTGGAAAGAAGATTCCAGTCCCTGATCAGTGTACCATTGAAGACACTGTGAGAAGT
TGTGTAGCAAAGTTGTTCTTCACCTGCTCCCTGAAGGGTCATTACTGCCTATACAGTAAGTCCAGTTTTATTCTCATCAGCCAAGAACCT
CAGCCATGGATCCAGATCATGTTTCTATTTCAGCAGAGCCTGTTTCCTGAACCCCTGTCCATTCAGAGTCATTCTGTGCAATTCCTCAGA
GCTCTGTGGGAGAAGACCCAGGCAGGGGGTGCTCACAGCTTTGAAACTGCCATGATGGAGTCCACGTTTCCACAGCAGAAGGATCTGGAC
CAGGTACAGCTCCATCTGGAAGAAGTGAGGTTCTTTGACGTGTTTGGCTTCAGTGAAACAGCAGGAGCATGGCAATGCTTCATGTGCAAC
AATCCTGAGAAAGCAACTGTTGTAAATCAAGATGGCCAGCCTCTCATAGAAGGAAAACTTAAAGAGAAGCAAGTCAGATGGAAGTTCATC
AAAAGGTGGAAAACACGCTATTTTACACTGGCTGGAAATCAACTTCTGTTTCAAAAAGGAAAGTCTAAAGATGACCCTGACGACTGCCCA
ATAGAACTCAGCAAAGTACAGAGTGTGAAGGCTGTGGCCAAGAAACGCAGGGACCGCTCTCTCCCCCGGGCTTTCGAAATCTTCACAGAC
AATAAAACCTATGTCTTTAAGGCCAAGGATGAGAAGAATGCAGAAGAATGGCTCCAGTGCATCAACGTGGCAGTTGCCCAAGCCAAAGAA
AGGGAAAGTAGAGAAGTAACCACATATCTGTAGGGATTTATAAGTCAGCCATGACAATTATACACCACAGGCATTGTATTATCATTGCCA
ATGTCAAGAAAAAGAGCTAAATTTACCAAGCCATGTTGTTTTTTACTAAATACCAATGGAATTGTTGTCCTTTAAGAAGAAGGGCCTAAA
ATGGCAGGATTCTTAGTAAATGTCATACTCTAACAGCTTTAGTATTGACTTCAGAATATATCTGATGCCCACAAAAATAAAATAAAATAA
AAGGAGCTACAGAGTATGCCCTCAGATAGTGTGGGGCCAGGAAGGGAAAAGTCACTGATAAAAGAACTTCTGTAGATATGTCATTTAAAA
CTGTGAGAAAACAACATGAAAAGATGCCTGAACTCTCCATCCTGAGGAAAGATTAGCACTTCTGATGAAAATCACAGTCTGTCAAAGGTA
TTAAAAGAAAACTTTAAAAAAAAAAACCTTTAGAAACGTTGAACTAATGTACACTGAGAAAAACCATATAACTTACTTATAGACATATAA
TTACATGATCCTCTCTTACTACAACTGAGGCTAACACATGGTAAAATGGTTCCCAAATCAAGCCAGTTATGTCATTAAATACTTGTCTTT
CAGAATTACTTATTTAATTATTCCATTTAAGTTCATATAATATAATCTACAGTTTAGATACTTGGACATATATCCTGCCCAAGGCACTAA
GTGTAATATAGGAAAAGGATAGAAAGCCATTTTCTCTATCTTCAAAATAATGTGCCATCTCCGTTAAAATTAAGACTTTAAAGTTCTATA
ATTTTTTCTTTGTATTCAACTTTTTAATACCTCCAAATTACAAACATCTATTTTTTTCACTACATAGATATATAATTACACTATGATAGA
CAGAATTCTAGAGTGATTCTCAATAATCCATGCCTTGGTATAATCCTCTCCCCCATTGAGTGTGGGTGGGACATGTAACCTGCTTCTAAC
CAACAGAATATGGCAAAAGTGATGGGATCATCTCTCCCATATTATGTTATGTTATATAACAAAAGTGAAGAGAAGTTGCAGATATACATA
AGGTTTCTAATCAGCTGACTTTGAGTTAATCAAAGAGATCCCCTGGGTGGGCCTGACCTAATCAGACTAGTCCTTTAAAAGAGAGTGAAC
CAGTCAGAGACTCTCTCTCCTATTAGCCTTAAATAAGCAAGCTGCCATGAGCTCTACGGCTGCAAGGAAATAAGTTTTGTGAACAACCAT
GTGATCTTGGAAGAAGCATCTGAACCTCAGATAAAAGCCCAGCCCCAGCCAACGCCTTGCTTGCAGCTTTGTGAAACTCTGAGCAGAGGA

>99017_99017_1_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000308378_VEPH1_chr3_157099165_ENST00000362010_length(amino acids)=748AA_BP=217
MAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD
IQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTG
QKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNS
FTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFN
RSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPE
TTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQ
SLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETAMMESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDG
QPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEK

--------------------------------------------------------------
>99017_99017_2_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000308378_VEPH1_chr3_157099165_ENST00000392832_length(transcript)=2778nt_BP=957nt
AGGCACCTGTTGAAGGAAAAAGAAGATCCATCCTTATAGAAATAGTTGAAGGCAACTGAGAAAAGGTGAAGCCATTATGAGTTGCCAGAA
AGCTGTACTTGAGTTAAACATAGGGTCACAGCTTGGGCCAAAGAGTCCTGAGAGAACAGAAGGTGTAACTGCATTTGAAGACTATGGCAC
AGGCCTGCTTGAAAACCAACTCAGCGTGGGTGACTTTGTAAAAATACAGAAGGCCTTTGAGTTACTTACAATGCATCTTTAGACGCTATC
ATTTCCAGTACAACCAGCAATACAAATAGTGTGGTGATGGCTTGGAGAGAGAAATCAAAAAAGCGTCTTAATATGACATCCTTCAACATT
GCCCAGGGCATTCATGCTTTTGATTATCACTCTCGGCTCAATTTAATTGCAACTGCTGGCATTAACAATAAAGTTTGCCTTTGGAATCCC
TATGTTGTCTCTAAACCAGTGGGTGTCCTTTGGGGCCACTCAGCCAGTGTAATAGCCGTCCAATTCTTTGTGGAAAGAAAACAACTTTTC
AGCTTCTCCAAGGATAAAGTTTTGAGACTCTGGGATATTCAACACCAGCTGTCCATCCAGAGGATAGCTTGTTCTTTCCCCAAAAGTCAG
GACTTCAGATGTCTCTTCCACTTTGATGAAGCCCATGGACGACTTTTCATCTCGTTTAATAACCAGCTAGCATTGTTGGCAATGAAAAGT
GAAGCCAGCAAGAGGGTGAAAAGCCATGAGAAAGCAGTCACTTGTGTTCTTTACAATTCTATCTTGAAGCAGGTAATCAGCTCTGATACA
GGGTCTACTGTTTCCTTCTGGATGATAGACACTGGGCAGAAAATCAAACAGTTTACTGGTTGCCACGGCAACGCAGAAATCAGCACTATG
GCCCTTGATGCAAATGAGACTCGGCTTTTGACTGGCAGCACAGATGGGACTGTAAAGGAGAGAGCCAGGAGCTGCCTGACATACCTGGTG
AGCCAACTGGCCAACATGGAGCATTCGTTTCACCATATTCTCCTGCTGGAGATTAAAAGCATCACCGACACCTTCTCCTCAATCTTGGGC
CCTCAGAGCAGAGACATCTTCCGCATGAGCAACAGCTTCACCGCCATTGCTAAACTCCTTACCCGACAACTGGAAAATACCAAGGCTGGA
AGTGGCAGGAGAAAAATCAGCACTGAAATTGAATTCCCTGAGAAACTGGAAGAAACCAAGCTCATAGTAACTGAAAATGAAGACCATGAA
AAACTCCAAGTTAAAATCCAGGCTTTTGAAGACAAGATAAATGCAGGGAGCAATACCCCTGGCTCTATCAGAAGATATAGTCTGGGCCAA
GTTTCTAAAGAAGAAAGAAAAAACATTAGATTTAACAGGTCAAAAAGTTTGGCTTTCCACACTATGCTCACAAAGGGTGTGGGTTCAGAT
GACGGCGAAGATGAAAACAGGGGAGACATACCAGCCAGCATCTCTCTTTCAGAAATAGACCCACTTGGCCAAGGAAATGACAAGCTGCCG
TTTAAGACAGACACTGAGAGATCACAGCTGGGGGAGTCTTCAGTTTCATACCCAAATATTATACATATAGACTCAGAGAATTTGTCAGAA
ACTGTTAAAGAAAACTCCCAGGAAGAAACTCCAGAGACAACTGCAAGTCCTATAGAATACCAAGATAAGCTCTACTTGCACTTAAAAAAA
AACCTCAGCAAAGTGAAAGCATATGCCATGGAAATTGGAAAGAAGATTCCAGTCCCTGATCAGTGTACCATTGAAGACACTGTGAGAAGT
TGTGTAGCAAAGTTGTTCTTCACCTGCTCCCTGAAGGGTCATTACTGCCTATACAGTAAGTCCAGTTTTATTCTCATCAGCCAAGAACCT
CAGCCATGGATCCAGATCATGTTTCTATTTCAGCAGAGCCTGTTTCCTGAACCCCTGTCCATTCAGAGTCATTCTGTGCAATTCCTCAGA
GCTCTGTGGGAGAAGACCCAGGCAGGGGGTGCTCACAGCTTTGAAACTGCCATGATGGAGTCCACGTTTCCACAGCAGAAGGATCTGGAC
CAGGTACAGCTCCATCTGGAAGAAGTGAGGTTCTTTGACGTGTTTGGCTTCAGTGAAACAGCAGGAGCATGGCAATGCTTCATGTGCAAC
AATCCTGAGAAAGCAACTGTTGTAAATCAAGATGGCCAGCCTCTCATAGAAGGAAAACTTAAAGAGAAGCAAGTCAGATGGAAGTTCATC
AAAAGGTGGAAAACACGCTATTTTACACTGGCTGGAAATCAACTTCTGTTTCAAAAAGGAAAGTCTAAAGATGACCCTGACGACTGCCCA
ATAGAACTCAGCAAAGTACAGAGTGTGAAGGCTGTGGCCAAGAAACGCAGGGACCGCTCTCTCCCCCGGGCTTTCGAAATCTTCACAGAC
AATAAAACCTATGTCTTTAAGGCCAAGGATGAGAAGAATGCAGAAGAATGGCTCCAGTGCATCAACGTGGCAGTTGCCCAAGCCAAAGAA
AGGGAAAGTAGAGAAGTAACCACATATCTGTAGGGATTTATAAGTCAGCCATGACAATTATACACCACAGGCATTGTATTATCATTGCCA
ATGTCAAGAAAAAGAGCTAAATTTACCAAGCCATGTTGTTTTTTACTAAATACCAATGGAATTGTTGTCCTTTAAGAAGAAGGGCCTAAA

>99017_99017_2_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000308378_VEPH1_chr3_157099165_ENST00000392832_length(amino acids)=748AA_BP=217
MAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD
IQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTG
QKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNS
FTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFN
RSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPE
TTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQ
SLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETAMMESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDG
QPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEK

--------------------------------------------------------------
>99017_99017_3_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000308378_VEPH1_chr3_157099165_ENST00000392833_length(transcript)=3810nt_BP=957nt
AGGCACCTGTTGAAGGAAAAAGAAGATCCATCCTTATAGAAATAGTTGAAGGCAACTGAGAAAAGGTGAAGCCATTATGAGTTGCCAGAA
AGCTGTACTTGAGTTAAACATAGGGTCACAGCTTGGGCCAAAGAGTCCTGAGAGAACAGAAGGTGTAACTGCATTTGAAGACTATGGCAC
AGGCCTGCTTGAAAACCAACTCAGCGTGGGTGACTTTGTAAAAATACAGAAGGCCTTTGAGTTACTTACAATGCATCTTTAGACGCTATC
ATTTCCAGTACAACCAGCAATACAAATAGTGTGGTGATGGCTTGGAGAGAGAAATCAAAAAAGCGTCTTAATATGACATCCTTCAACATT
GCCCAGGGCATTCATGCTTTTGATTATCACTCTCGGCTCAATTTAATTGCAACTGCTGGCATTAACAATAAAGTTTGCCTTTGGAATCCC
TATGTTGTCTCTAAACCAGTGGGTGTCCTTTGGGGCCACTCAGCCAGTGTAATAGCCGTCCAATTCTTTGTGGAAAGAAAACAACTTTTC
AGCTTCTCCAAGGATAAAGTTTTGAGACTCTGGGATATTCAACACCAGCTGTCCATCCAGAGGATAGCTTGTTCTTTCCCCAAAAGTCAG
GACTTCAGATGTCTCTTCCACTTTGATGAAGCCCATGGACGACTTTTCATCTCGTTTAATAACCAGCTAGCATTGTTGGCAATGAAAAGT
GAAGCCAGCAAGAGGGTGAAAAGCCATGAGAAAGCAGTCACTTGTGTTCTTTACAATTCTATCTTGAAGCAGGTAATCAGCTCTGATACA
GGGTCTACTGTTTCCTTCTGGATGATAGACACTGGGCAGAAAATCAAACAGTTTACTGGTTGCCACGGCAACGCAGAAATCAGCACTATG
GCCCTTGATGCAAATGAGACTCGGCTTTTGACTGGCAGCACAGATGGGACTGTAAAGGAGAGAGCCAGGAGCTGCCTGACATACCTGGTG
AGCCAACTGGCCAACATGGAGCATTCGTTTCACCATATTCTCCTGCTGGAGATTAAAAGCATCACCGACACCTTCTCCTCAATCTTGGGC
CCTCAGAGCAGAGACATCTTCCGCATGAGCAACAGCTTCACCGCCATTGCTAAACTCCTTACCCGACAACTGGAAAATACCAAGGCTGGA
AGTGGCAGGAGAAAAATCAGCACTGAAATTGAATTCCCTGAGAAACTGGAAGAAACCAAGCTCATAGTAACTGAAAATGAAGACCATGAA
AAACTCCAAGTTAAAATCCAGGCTTTTGAAGACAAGATAAATGCAGGGAGCAATACCCCTGGCTCTATCAGAAGATATAGTCTGGGCCAA
GTTTCTAAAGAAGAAAGAAAAAACATTAGATTTAACAGGTCAAAAAGTTTGGCTTTCCACACTATGCTCACAAAGGGTGTGGGTTCAGAT
GACGGCGAAGATGAAAACAGGGGAGACATACCAGCCAGCATCTCTCTTTCAGAAATAGACCCACTTGGCCAAGGAAATGACAAGCTGCCG
TTTAAGACAGACACTGAGAGATCACAGCTGGGGGAGTCTTCAGTTTCATACCCAAATATTATACATATAGACTCAGAGAATTTGTCAGAA
ACTGTTAAAGAAAACTCCCAGGAAGAAACTCCAGAGACAACTGCAAGTCCTATAGAATACCAAGATAAGCTCTACTTGCACTTAAAAAAA
AACCTCAGCAAAGTGAAAGCATATGCCATGGAAATTGGAAAGAAGATTCCAGTCCCTGATCAGTGTACCATTGAAGACACTGTGAGAAGT
TGTGTAGCAAAGTTGTTCTTCACCTGCTCCCTGAAGGGTCATTACTGCCTATACAGTAAGTCCAGTTTTATTCTCATCAGCCAAGAACCT
CAGCCATGGATCCAGATCATGTTTCTATTTCAGCAGGATCTGGACCAGGTACAGCTCCATCTGGAAGAAGTGAGGTTCTTTGACGTGTTT
GGCTTCAGTGAAACAGCAGGAGCATGGCAATGCTTCATGTGCAACAATCCTGAGAAAGCAACTGTTGTAAATCAAGATGGCCAGCCTCTC
ATAGAAGGAAAACTTAAAGAGAAGCAAGTCAGATGGAAGTTCATCAAAAGGTGGAAAACACGCTATTTTACACTGGCTGGAAATCAACTT
CTGTTTCAAAAAGGAAAGTCTAAAGATGACCCTGACGACTGCCCAATAGAACTCAGCAAAGTACAGAGTGTGAAGGCTGTGGCCAAGAAA
CGCAGGGACCGCTCTCTCCCCCGGGCTTTCGAAATCTTCACAGACAATAAAACCTATGTCTTTAAGGCCAAGGATGAGAAGAATGCAGAA
GAATGGCTCCAGTGCATCAACGTGGCAGTTGCCCAAGCCAAAGAAAGGGAAAGTAGAGAAGTAACCACATATCTGTAGGGATTTATAAGT
CAGCCATGACAATTATACACCACAGGCATTGTATTATCATTGCCAATGTCAAGAAAAAGAGCTAAATTTACCAAGCCATGTTGTTTTTTA
CTAAATACCAATGGAATTGTTGTCCTTTAAGAAGAAGGGCCTAAAATGGCAGGATTCTTAGTAAATGTCATACTCTAACAGCTTTAGTAT
TGACTTCAGAATATATCTGATGCCCACAAAAATAAAATAAAATAAAAGGAGCTACAGAGTATGCCCTCAGATAGTGTGGGGCCAGGAAGG
GAAAAGTCACTGATAAAAGAACTTCTGTAGATATGTCATTTAAAACTGTGAGAAAACAACATGAAAAGATGCCTGAACTCTCCATCCTGA
GGAAAGATTAGCACTTCTGATGAAAATCACAGTCTGTCAAAGGTATTAAAAGAAAACTTTAAAAAAAAAAACCTTTAGAAACGTTGAACT
AATGTACACTGAGAAAAACCATATAACTTACTTATAGACATATAATTACATGATCCTCTCTTACTACAACTGAGGCTAACACATGGTAAA
ATGGTTCCCAAATCAAGCCAGTTATGTCATTAAATACTTGTCTTTCAGAATTACTTATTTAATTATTCCATTTAAGTTCATATAATATAA
TCTACAGTTTAGATACTTGGACATATATCCTGCCCAAGGCACTAAGTGTAATATAGGAAAAGGATAGAAAGCCATTTTCTCTATCTTCAA
AATAATGTGCCATCTCCGTTAAAATTAAGACTTTAAAGTTCTATAATTTTTTCTTTGTATTCAACTTTTTAATACCTCCAAATTACAAAC
ATCTATTTTTTTCACTACATAGATATATAATTACACTATGATAGACAGAATTCTAGAGTGATTCTCAATAATCCATGCCTTGGTATAATC
CTCTCCCCCATTGAGTGTGGGTGGGACATGTAACCTGCTTCTAACCAACAGAATATGGCAAAAGTGATGGGATCATCTCTCCCATATTAT
GTTATGTTATATAACAAAAGTGAAGAGAAGTTGCAGATATACATAAGGTTTCTAATCAGCTGACTTTGAGTTAATCAAAGAGATCCCCTG
GGTGGGCCTGACCTAATCAGACTAGTCCTTTAAAAGAGAGTGAACCAGTCAGAGACTCTCTCTCCTATTAGCCTTAAATAAGCAAGCTGC
CATGAGCTCTACGGCTGCAAGGAAATAAGTTTTGTGAACAACCATGTGATCTTGGAAGAAGCATCTGAACCTCAGATAAAAGCCCAGCCC
CAGCCAACGCCTTGCTTGCAGCTTTGTGAAACTCTGAGCAGAGGACCCAGCTAAATCACGTTTGGACTCCTGACCCACAGAAACTTTCAG

>99017_99017_3_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000308378_VEPH1_chr3_157099165_ENST00000392833_length(amino acids)=703AA_BP=217
MAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD
IQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTG
QKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNS
FTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFN
RSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPE
TTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQ
DLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPD

--------------------------------------------------------------
>99017_99017_4_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000308378_VEPH1_chr3_157099165_ENST00000543418_length(transcript)=3810nt_BP=957nt
AGGCACCTGTTGAAGGAAAAAGAAGATCCATCCTTATAGAAATAGTTGAAGGCAACTGAGAAAAGGTGAAGCCATTATGAGTTGCCAGAA
AGCTGTACTTGAGTTAAACATAGGGTCACAGCTTGGGCCAAAGAGTCCTGAGAGAACAGAAGGTGTAACTGCATTTGAAGACTATGGCAC
AGGCCTGCTTGAAAACCAACTCAGCGTGGGTGACTTTGTAAAAATACAGAAGGCCTTTGAGTTACTTACAATGCATCTTTAGACGCTATC
ATTTCCAGTACAACCAGCAATACAAATAGTGTGGTGATGGCTTGGAGAGAGAAATCAAAAAAGCGTCTTAATATGACATCCTTCAACATT
GCCCAGGGCATTCATGCTTTTGATTATCACTCTCGGCTCAATTTAATTGCAACTGCTGGCATTAACAATAAAGTTTGCCTTTGGAATCCC
TATGTTGTCTCTAAACCAGTGGGTGTCCTTTGGGGCCACTCAGCCAGTGTAATAGCCGTCCAATTCTTTGTGGAAAGAAAACAACTTTTC
AGCTTCTCCAAGGATAAAGTTTTGAGACTCTGGGATATTCAACACCAGCTGTCCATCCAGAGGATAGCTTGTTCTTTCCCCAAAAGTCAG
GACTTCAGATGTCTCTTCCACTTTGATGAAGCCCATGGACGACTTTTCATCTCGTTTAATAACCAGCTAGCATTGTTGGCAATGAAAAGT
GAAGCCAGCAAGAGGGTGAAAAGCCATGAGAAAGCAGTCACTTGTGTTCTTTACAATTCTATCTTGAAGCAGGTAATCAGCTCTGATACA
GGGTCTACTGTTTCCTTCTGGATGATAGACACTGGGCAGAAAATCAAACAGTTTACTGGTTGCCACGGCAACGCAGAAATCAGCACTATG
GCCCTTGATGCAAATGAGACTCGGCTTTTGACTGGCAGCACAGATGGGACTGTAAAGGAGAGAGCCAGGAGCTGCCTGACATACCTGGTG
AGCCAACTGGCCAACATGGAGCATTCGTTTCACCATATTCTCCTGCTGGAGATTAAAAGCATCACCGACACCTTCTCCTCAATCTTGGGC
CCTCAGAGCAGAGACATCTTCCGCATGAGCAACAGCTTCACCGCCATTGCTAAACTCCTTACCCGACAACTGGAAAATACCAAGGCTGGA
AGTGGCAGGAGAAAAATCAGCACTGAAATTGAATTCCCTGAGAAACTGGAAGAAACCAAGCTCATAGTAACTGAAAATGAAGACCATGAA
AAACTCCAAGTTAAAATCCAGGCTTTTGAAGACAAGATAAATGCAGGGAGCAATACCCCTGGCTCTATCAGAAGATATAGTCTGGGCCAA
GTTTCTAAAGAAGAAAGAAAAAACATTAGATTTAACAGGTCAAAAAGTTTGGCTTTCCACACTATGCTCACAAAGGGTGTGGGTTCAGAT
GACGGCGAAGATGAAAACAGGGGAGACATACCAGCCAGCATCTCTCTTTCAGAAATAGACCCACTTGGCCAAGGAAATGACAAGCTGCCG
TTTAAGACAGACACTGAGAGATCACAGCTGGGGGAGTCTTCAGTTTCATACCCAAATATTATACATATAGACTCAGAGAATTTGTCAGAA
ACTGTTAAAGAAAACTCCCAGGAAGAAACTCCAGAGACAACTGCAAGTCCTATAGAATACCAAGATAAGCTCTACTTGCACTTAAAAAAA
AACCTCAGCAAAGTGAAAGCATATGCCATGGAAATTGGAAAGAAGATTCCAGTCCCTGATCAGTGTACCATTGAAGACACTGTGAGAAGT
TGTGTAGCAAAGTTGTTCTTCACCTGCTCCCTGAAGGGTCATTACTGCCTATACAGTAAGTCCAGTTTTATTCTCATCAGCCAAGAACCT
CAGCCATGGATCCAGATCATGTTTCTATTTCAGCAGGATCTGGACCAGGTACAGCTCCATCTGGAAGAAGTGAGGTTCTTTGACGTGTTT
GGCTTCAGTGAAACAGCAGGAGCATGGCAATGCTTCATGTGCAACAATCCTGAGAAAGCAACTGTTGTAAATCAAGATGGCCAGCCTCTC
ATAGAAGGAAAACTTAAAGAGAAGCAAGTCAGATGGAAGTTCATCAAAAGGTGGAAAACACGCTATTTTACACTGGCTGGAAATCAACTT
CTGTTTCAAAAAGGAAAGTCTAAAGATGACCCTGACGACTGCCCAATAGAACTCAGCAAAGTACAGAGTGTGAAGGCTGTGGCCAAGAAA
CGCAGGGACCGCTCTCTCCCCCGGGCTTTCGAAATCTTCACAGACAATAAAACCTATGTCTTTAAGGCCAAGGATGAGAAGAATGCAGAA
GAATGGCTCCAGTGCATCAACGTGGCAGTTGCCCAAGCCAAAGAAAGGGAAAGTAGAGAAGTAACCACATATCTGTAGGGATTTATAAGT
CAGCCATGACAATTATACACCACAGGCATTGTATTATCATTGCCAATGTCAAGAAAAAGAGCTAAATTTACCAAGCCATGTTGTTTTTTA
CTAAATACCAATGGAATTGTTGTCCTTTAAGAAGAAGGGCCTAAAATGGCAGGATTCTTAGTAAATGTCATACTCTAACAGCTTTAGTAT
TGACTTCAGAATATATCTGATGCCCACAAAAATAAAATAAAATAAAAGGAGCTACAGAGTATGCCCTCAGATAGTGTGGGGCCAGGAAGG
GAAAAGTCACTGATAAAAGAACTTCTGTAGATATGTCATTTAAAACTGTGAGAAAACAACATGAAAAGATGCCTGAACTCTCCATCCTGA
GGAAAGATTAGCACTTCTGATGAAAATCACAGTCTGTCAAAGGTATTAAAAGAAAACTTTAAAAAAAAAAACCTTTAGAAACGTTGAACT
AATGTACACTGAGAAAAACCATATAACTTACTTATAGACATATAATTACATGATCCTCTCTTACTACAACTGAGGCTAACACATGGTAAA
ATGGTTCCCAAATCAAGCCAGTTATGTCATTAAATACTTGTCTTTCAGAATTACTTATTTAATTATTCCATTTAAGTTCATATAATATAA
TCTACAGTTTAGATACTTGGACATATATCCTGCCCAAGGCACTAAGTGTAATATAGGAAAAGGATAGAAAGCCATTTTCTCTATCTTCAA
AATAATGTGCCATCTCCGTTAAAATTAAGACTTTAAAGTTCTATAATTTTTTCTTTGTATTCAACTTTTTAATACCTCCAAATTACAAAC
ATCTATTTTTTTCACTACATAGATATATAATTACACTATGATAGACAGAATTCTAGAGTGATTCTCAATAATCCATGCCTTGGTATAATC
CTCTCCCCCATTGAGTGTGGGTGGGACATGTAACCTGCTTCTAACCAACAGAATATGGCAAAAGTGATGGGATCATCTCTCCCATATTAT
GTTATGTTATATAACAAAAGTGAAGAGAAGTTGCAGATATACATAAGGTTTCTAATCAGCTGACTTTGAGTTAATCAAAGAGATCCCCTG
GGTGGGCCTGACCTAATCAGACTAGTCCTTTAAAAGAGAGTGAACCAGTCAGAGACTCTCTCTCCTATTAGCCTTAAATAAGCAAGCTGC
CATGAGCTCTACGGCTGCAAGGAAATAAGTTTTGTGAACAACCATGTGATCTTGGAAGAAGCATCTGAACCTCAGATAAAAGCCCAGCCC
CAGCCAACGCCTTGCTTGCAGCTTTGTGAAACTCTGAGCAGAGGACCCAGCTAAATCACGTTTGGACTCCTGACCCACAGAAACTTTCAG

>99017_99017_4_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000308378_VEPH1_chr3_157099165_ENST00000543418_length(amino acids)=703AA_BP=217
MAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD
IQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTG
QKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNS
FTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFN
RSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPE
TTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQ
DLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPD

--------------------------------------------------------------
>99017_99017_5_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000453925_VEPH1_chr3_157099165_ENST00000362010_length(transcript)=3833nt_BP=845nt
GGCCTGCTAGTGCATGTGAAGATGGAGAAGCCACTATGACCATTAACTGGGCAGAGCTGCTCTCTGGATGTCACAAATGTTGCCATATAT
TAGAGCATAAACTTCATCAAGGAGATTGGGTCAGGCAAGTTACTTACAATGCATCTTTAGACGCTATCATTTCCAGTACAACCAGCAATA
CAAATAGTGTGGTGATGGCTTGGAGAGAGAAATCAAAAAAGCGTCTTAATATGACATCCTTCAACATTGCCCAGGGCATTCATGCTTTTG
ATTATCACTCTCGGCTCAATTTAATTGCAACTGCTGGCATTAACAATAAAGTTTGCCTTTGGAATCCCTATGTTGTCTCTAAACCAGTGG
GTGTCCTTTGGGGCCACTCAGCCAGTGTAATAGCCGTCCAATTCTTTGTGGAAAGAAAACAACTTTTCAGCTTCTCCAAGGATAAAGTTT
TGAGACTCTGGGATATTCAACACCAGCTGTCCATCCAGAGGATAGCTTGTTCTTTCCCCAAAAGTCAGGACTTCAGATGTCTCTTCCACT
TTGATGAAGCCCATGGACGACTTTTCATCTCGTTTAATAACCAGCTAGCATTGTTGGCAATGAAAAGTGAAGCCAGCAAGAGGGTGAAAA
GCCATGAGAAAGCAGTCACTTGTGTTCTTTACAATTCTATCTTGAAGCAGGTAATCAGCTCTGATACAGGGTCTACTGTTTCCTTCTGGA
TGATAGACACTGGGCAGAAAATCAAACAGTTTACTGGTTGCCACGGCAACGCAGAAATCAGCACTATGGCCCTTGATGCAAATGAGACTC
GGCTTTTGACTGGCAGCACAGATGGGACTGTAAAGGAGAGAGCCAGGAGCTGCCTGACATACCTGGTGAGCCAACTGGCCAACATGGAGC
ATTCGTTTCACCATATTCTCCTGCTGGAGATTAAAAGCATCACCGACACCTTCTCCTCAATCTTGGGCCCTCAGAGCAGAGACATCTTCC
GCATGAGCAACAGCTTCACCGCCATTGCTAAACTCCTTACCCGACAACTGGAAAATACCAAGGCTGGAAGTGGCAGGAGAAAAATCAGCA
CTGAAATTGAATTCCCTGAGAAACTGGAAGAAACCAAGCTCATAGTAACTGAAAATGAAGACCATGAAAAACTCCAAGTTAAAATCCAGG
CTTTTGAAGACAAGATAAATGCAGGGAGCAATACCCCTGGCTCTATCAGAAGATATAGTCTGGGCCAAGTTTCTAAAGAAGAAAGAAAAA
ACATTAGATTTAACAGGTCAAAAAGTTTGGCTTTCCACACTATGCTCACAAAGGGTGTGGGTTCAGATGACGGCGAAGATGAAAACAGGG
GAGACATACCAGCCAGCATCTCTCTTTCAGAAATAGACCCACTTGGCCAAGGAAATGACAAGCTGCCGTTTAAGACAGACACTGAGAGAT
CACAGCTGGGGGAGTCTTCAGTTTCATACCCAAATATTATACATATAGACTCAGAGAATTTGTCAGAAACTGTTAAAGAAAACTCCCAGG
AAGAAACTCCAGAGACAACTGCAAGTCCTATAGAATACCAAGATAAGCTCTACTTGCACTTAAAAAAAAACCTCAGCAAAGTGAAAGCAT
ATGCCATGGAAATTGGAAAGAAGATTCCAGTCCCTGATCAGTGTACCATTGAAGACACTGTGAGAAGTTGTGTAGCAAAGTTGTTCTTCA
CCTGCTCCCTGAAGGGTCATTACTGCCTATACAGTAAGTCCAGTTTTATTCTCATCAGCCAAGAACCTCAGCCATGGATCCAGATCATGT
TTCTATTTCAGCAGAGCCTGTTTCCTGAACCCCTGTCCATTCAGAGTCATTCTGTGCAATTCCTCAGAGCTCTGTGGGAGAAGACCCAGG
CAGGGGGTGCTCACAGCTTTGAAACTGCCATGATGGAGTCCACGTTTCCACAGCAGAAGGATCTGGACCAGGTACAGCTCCATCTGGAAG
AAGTGAGGTTCTTTGACGTGTTTGGCTTCAGTGAAACAGCAGGAGCATGGCAATGCTTCATGTGCAACAATCCTGAGAAAGCAACTGTTG
TAAATCAAGATGGCCAGCCTCTCATAGAAGGAAAACTTAAAGAGAAGCAAGTCAGATGGAAGTTCATCAAAAGGTGGAAAACACGCTATT
TTACACTGGCTGGAAATCAACTTCTGTTTCAAAAAGGAAAGTCTAAAGATGACCCTGACGACTGCCCAATAGAACTCAGCAAAGTACAGA
GTGTGAAGGCTGTGGCCAAGAAACGCAGGGACCGCTCTCTCCCCCGGGCTTTCGAAATCTTCACAGACAATAAAACCTATGTCTTTAAGG
CCAAGGATGAGAAGAATGCAGAAGAATGGCTCCAGTGCATCAACGTGGCAGTTGCCCAAGCCAAAGAAAGGGAAAGTAGAGAAGTAACCA
CATATCTGTAGGGATTTATAAGTCAGCCATGACAATTATACACCACAGGCATTGTATTATCATTGCCAATGTCAAGAAAAAGAGCTAAAT
TTACCAAGCCATGTTGTTTTTTACTAAATACCAATGGAATTGTTGTCCTTTAAGAAGAAGGGCCTAAAATGGCAGGATTCTTAGTAAATG
TCATACTCTAACAGCTTTAGTATTGACTTCAGAATATATCTGATGCCCACAAAAATAAAATAAAATAAAAGGAGCTACAGAGTATGCCCT
CAGATAGTGTGGGGCCAGGAAGGGAAAAGTCACTGATAAAAGAACTTCTGTAGATATGTCATTTAAAACTGTGAGAAAACAACATGAAAA
GATGCCTGAACTCTCCATCCTGAGGAAAGATTAGCACTTCTGATGAAAATCACAGTCTGTCAAAGGTATTAAAAGAAAACTTTAAAAAAA
AAAACCTTTAGAAACGTTGAACTAATGTACACTGAGAAAAACCATATAACTTACTTATAGACATATAATTACATGATCCTCTCTTACTAC
AACTGAGGCTAACACATGGTAAAATGGTTCCCAAATCAAGCCAGTTATGTCATTAAATACTTGTCTTTCAGAATTACTTATTTAATTATT
CCATTTAAGTTCATATAATATAATCTACAGTTTAGATACTTGGACATATATCCTGCCCAAGGCACTAAGTGTAATATAGGAAAAGGATAG
AAAGCCATTTTCTCTATCTTCAAAATAATGTGCCATCTCCGTTAAAATTAAGACTTTAAAGTTCTATAATTTTTTCTTTGTATTCAACTT
TTTAATACCTCCAAATTACAAACATCTATTTTTTTCACTACATAGATATATAATTACACTATGATAGACAGAATTCTAGAGTGATTCTCA
ATAATCCATGCCTTGGTATAATCCTCTCCCCCATTGAGTGTGGGTGGGACATGTAACCTGCTTCTAACCAACAGAATATGGCAAAAGTGA
TGGGATCATCTCTCCCATATTATGTTATGTTATATAACAAAAGTGAAGAGAAGTTGCAGATATACATAAGGTTTCTAATCAGCTGACTTT
GAGTTAATCAAAGAGATCCCCTGGGTGGGCCTGACCTAATCAGACTAGTCCTTTAAAAGAGAGTGAACCAGTCAGAGACTCTCTCTCCTA
TTAGCCTTAAATAAGCAAGCTGCCATGAGCTCTACGGCTGCAAGGAAATAAGTTTTGTGAACAACCATGTGATCTTGGAAGAAGCATCTG
AACCTCAGATAAAAGCCCAGCCCCAGCCAACGCCTTGCTTGCAGCTTTGTGAAACTCTGAGCAGAGGACCCAGCTAAATCACGTTTGGAC

>99017_99017_5_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000453925_VEPH1_chr3_157099165_ENST00000362010_length(amino acids)=801AA_BP=270
MTINWAELLSGCHKCCHILEHKLHQGDWVRQVTYNASLDAIISSTTSNTNSVVMAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATA
GINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISF
NNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVK
ERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEET
KLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEI
DPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVP
DQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETAMM
ESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQK

--------------------------------------------------------------
>99017_99017_6_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000453925_VEPH1_chr3_157099165_ENST00000392832_length(transcript)=2666nt_BP=845nt
GGCCTGCTAGTGCATGTGAAGATGGAGAAGCCACTATGACCATTAACTGGGCAGAGCTGCTCTCTGGATGTCACAAATGTTGCCATATAT
TAGAGCATAAACTTCATCAAGGAGATTGGGTCAGGCAAGTTACTTACAATGCATCTTTAGACGCTATCATTTCCAGTACAACCAGCAATA
CAAATAGTGTGGTGATGGCTTGGAGAGAGAAATCAAAAAAGCGTCTTAATATGACATCCTTCAACATTGCCCAGGGCATTCATGCTTTTG
ATTATCACTCTCGGCTCAATTTAATTGCAACTGCTGGCATTAACAATAAAGTTTGCCTTTGGAATCCCTATGTTGTCTCTAAACCAGTGG
GTGTCCTTTGGGGCCACTCAGCCAGTGTAATAGCCGTCCAATTCTTTGTGGAAAGAAAACAACTTTTCAGCTTCTCCAAGGATAAAGTTT
TGAGACTCTGGGATATTCAACACCAGCTGTCCATCCAGAGGATAGCTTGTTCTTTCCCCAAAAGTCAGGACTTCAGATGTCTCTTCCACT
TTGATGAAGCCCATGGACGACTTTTCATCTCGTTTAATAACCAGCTAGCATTGTTGGCAATGAAAAGTGAAGCCAGCAAGAGGGTGAAAA
GCCATGAGAAAGCAGTCACTTGTGTTCTTTACAATTCTATCTTGAAGCAGGTAATCAGCTCTGATACAGGGTCTACTGTTTCCTTCTGGA
TGATAGACACTGGGCAGAAAATCAAACAGTTTACTGGTTGCCACGGCAACGCAGAAATCAGCACTATGGCCCTTGATGCAAATGAGACTC
GGCTTTTGACTGGCAGCACAGATGGGACTGTAAAGGAGAGAGCCAGGAGCTGCCTGACATACCTGGTGAGCCAACTGGCCAACATGGAGC
ATTCGTTTCACCATATTCTCCTGCTGGAGATTAAAAGCATCACCGACACCTTCTCCTCAATCTTGGGCCCTCAGAGCAGAGACATCTTCC
GCATGAGCAACAGCTTCACCGCCATTGCTAAACTCCTTACCCGACAACTGGAAAATACCAAGGCTGGAAGTGGCAGGAGAAAAATCAGCA
CTGAAATTGAATTCCCTGAGAAACTGGAAGAAACCAAGCTCATAGTAACTGAAAATGAAGACCATGAAAAACTCCAAGTTAAAATCCAGG
CTTTTGAAGACAAGATAAATGCAGGGAGCAATACCCCTGGCTCTATCAGAAGATATAGTCTGGGCCAAGTTTCTAAAGAAGAAAGAAAAA
ACATTAGATTTAACAGGTCAAAAAGTTTGGCTTTCCACACTATGCTCACAAAGGGTGTGGGTTCAGATGACGGCGAAGATGAAAACAGGG
GAGACATACCAGCCAGCATCTCTCTTTCAGAAATAGACCCACTTGGCCAAGGAAATGACAAGCTGCCGTTTAAGACAGACACTGAGAGAT
CACAGCTGGGGGAGTCTTCAGTTTCATACCCAAATATTATACATATAGACTCAGAGAATTTGTCAGAAACTGTTAAAGAAAACTCCCAGG
AAGAAACTCCAGAGACAACTGCAAGTCCTATAGAATACCAAGATAAGCTCTACTTGCACTTAAAAAAAAACCTCAGCAAAGTGAAAGCAT
ATGCCATGGAAATTGGAAAGAAGATTCCAGTCCCTGATCAGTGTACCATTGAAGACACTGTGAGAAGTTGTGTAGCAAAGTTGTTCTTCA
CCTGCTCCCTGAAGGGTCATTACTGCCTATACAGTAAGTCCAGTTTTATTCTCATCAGCCAAGAACCTCAGCCATGGATCCAGATCATGT
TTCTATTTCAGCAGAGCCTGTTTCCTGAACCCCTGTCCATTCAGAGTCATTCTGTGCAATTCCTCAGAGCTCTGTGGGAGAAGACCCAGG
CAGGGGGTGCTCACAGCTTTGAAACTGCCATGATGGAGTCCACGTTTCCACAGCAGAAGGATCTGGACCAGGTACAGCTCCATCTGGAAG
AAGTGAGGTTCTTTGACGTGTTTGGCTTCAGTGAAACAGCAGGAGCATGGCAATGCTTCATGTGCAACAATCCTGAGAAAGCAACTGTTG
TAAATCAAGATGGCCAGCCTCTCATAGAAGGAAAACTTAAAGAGAAGCAAGTCAGATGGAAGTTCATCAAAAGGTGGAAAACACGCTATT
TTACACTGGCTGGAAATCAACTTCTGTTTCAAAAAGGAAAGTCTAAAGATGACCCTGACGACTGCCCAATAGAACTCAGCAAAGTACAGA
GTGTGAAGGCTGTGGCCAAGAAACGCAGGGACCGCTCTCTCCCCCGGGCTTTCGAAATCTTCACAGACAATAAAACCTATGTCTTTAAGG
CCAAGGATGAGAAGAATGCAGAAGAATGGCTCCAGTGCATCAACGTGGCAGTTGCCCAAGCCAAAGAAAGGGAAAGTAGAGAAGTAACCA
CATATCTGTAGGGATTTATAAGTCAGCCATGACAATTATACACCACAGGCATTGTATTATCATTGCCAATGTCAAGAAAAAGAGCTAAAT
TTACCAAGCCATGTTGTTTTTTACTAAATACCAATGGAATTGTTGTCCTTTAAGAAGAAGGGCCTAAAATGGCAGGATTCTTAGTAAATG

>99017_99017_6_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000453925_VEPH1_chr3_157099165_ENST00000392832_length(amino acids)=801AA_BP=270
MTINWAELLSGCHKCCHILEHKLHQGDWVRQVTYNASLDAIISSTTSNTNSVVMAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATA
GINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISF
NNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVK
ERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEET
KLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEI
DPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVP
DQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETAMM
ESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQK

--------------------------------------------------------------
>99017_99017_7_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000453925_VEPH1_chr3_157099165_ENST00000392833_length(transcript)=3698nt_BP=845nt
GGCCTGCTAGTGCATGTGAAGATGGAGAAGCCACTATGACCATTAACTGGGCAGAGCTGCTCTCTGGATGTCACAAATGTTGCCATATAT
TAGAGCATAAACTTCATCAAGGAGATTGGGTCAGGCAAGTTACTTACAATGCATCTTTAGACGCTATCATTTCCAGTACAACCAGCAATA
CAAATAGTGTGGTGATGGCTTGGAGAGAGAAATCAAAAAAGCGTCTTAATATGACATCCTTCAACATTGCCCAGGGCATTCATGCTTTTG
ATTATCACTCTCGGCTCAATTTAATTGCAACTGCTGGCATTAACAATAAAGTTTGCCTTTGGAATCCCTATGTTGTCTCTAAACCAGTGG
GTGTCCTTTGGGGCCACTCAGCCAGTGTAATAGCCGTCCAATTCTTTGTGGAAAGAAAACAACTTTTCAGCTTCTCCAAGGATAAAGTTT
TGAGACTCTGGGATATTCAACACCAGCTGTCCATCCAGAGGATAGCTTGTTCTTTCCCCAAAAGTCAGGACTTCAGATGTCTCTTCCACT
TTGATGAAGCCCATGGACGACTTTTCATCTCGTTTAATAACCAGCTAGCATTGTTGGCAATGAAAAGTGAAGCCAGCAAGAGGGTGAAAA
GCCATGAGAAAGCAGTCACTTGTGTTCTTTACAATTCTATCTTGAAGCAGGTAATCAGCTCTGATACAGGGTCTACTGTTTCCTTCTGGA
TGATAGACACTGGGCAGAAAATCAAACAGTTTACTGGTTGCCACGGCAACGCAGAAATCAGCACTATGGCCCTTGATGCAAATGAGACTC
GGCTTTTGACTGGCAGCACAGATGGGACTGTAAAGGAGAGAGCCAGGAGCTGCCTGACATACCTGGTGAGCCAACTGGCCAACATGGAGC
ATTCGTTTCACCATATTCTCCTGCTGGAGATTAAAAGCATCACCGACACCTTCTCCTCAATCTTGGGCCCTCAGAGCAGAGACATCTTCC
GCATGAGCAACAGCTTCACCGCCATTGCTAAACTCCTTACCCGACAACTGGAAAATACCAAGGCTGGAAGTGGCAGGAGAAAAATCAGCA
CTGAAATTGAATTCCCTGAGAAACTGGAAGAAACCAAGCTCATAGTAACTGAAAATGAAGACCATGAAAAACTCCAAGTTAAAATCCAGG
CTTTTGAAGACAAGATAAATGCAGGGAGCAATACCCCTGGCTCTATCAGAAGATATAGTCTGGGCCAAGTTTCTAAAGAAGAAAGAAAAA
ACATTAGATTTAACAGGTCAAAAAGTTTGGCTTTCCACACTATGCTCACAAAGGGTGTGGGTTCAGATGACGGCGAAGATGAAAACAGGG
GAGACATACCAGCCAGCATCTCTCTTTCAGAAATAGACCCACTTGGCCAAGGAAATGACAAGCTGCCGTTTAAGACAGACACTGAGAGAT
CACAGCTGGGGGAGTCTTCAGTTTCATACCCAAATATTATACATATAGACTCAGAGAATTTGTCAGAAACTGTTAAAGAAAACTCCCAGG
AAGAAACTCCAGAGACAACTGCAAGTCCTATAGAATACCAAGATAAGCTCTACTTGCACTTAAAAAAAAACCTCAGCAAAGTGAAAGCAT
ATGCCATGGAAATTGGAAAGAAGATTCCAGTCCCTGATCAGTGTACCATTGAAGACACTGTGAGAAGTTGTGTAGCAAAGTTGTTCTTCA
CCTGCTCCCTGAAGGGTCATTACTGCCTATACAGTAAGTCCAGTTTTATTCTCATCAGCCAAGAACCTCAGCCATGGATCCAGATCATGT
TTCTATTTCAGCAGGATCTGGACCAGGTACAGCTCCATCTGGAAGAAGTGAGGTTCTTTGACGTGTTTGGCTTCAGTGAAACAGCAGGAG
CATGGCAATGCTTCATGTGCAACAATCCTGAGAAAGCAACTGTTGTAAATCAAGATGGCCAGCCTCTCATAGAAGGAAAACTTAAAGAGA
AGCAAGTCAGATGGAAGTTCATCAAAAGGTGGAAAACACGCTATTTTACACTGGCTGGAAATCAACTTCTGTTTCAAAAAGGAAAGTCTA
AAGATGACCCTGACGACTGCCCAATAGAACTCAGCAAAGTACAGAGTGTGAAGGCTGTGGCCAAGAAACGCAGGGACCGCTCTCTCCCCC
GGGCTTTCGAAATCTTCACAGACAATAAAACCTATGTCTTTAAGGCCAAGGATGAGAAGAATGCAGAAGAATGGCTCCAGTGCATCAACG
TGGCAGTTGCCCAAGCCAAAGAAAGGGAAAGTAGAGAAGTAACCACATATCTGTAGGGATTTATAAGTCAGCCATGACAATTATACACCA
CAGGCATTGTATTATCATTGCCAATGTCAAGAAAAAGAGCTAAATTTACCAAGCCATGTTGTTTTTTACTAAATACCAATGGAATTGTTG
TCCTTTAAGAAGAAGGGCCTAAAATGGCAGGATTCTTAGTAAATGTCATACTCTAACAGCTTTAGTATTGACTTCAGAATATATCTGATG
CCCACAAAAATAAAATAAAATAAAAGGAGCTACAGAGTATGCCCTCAGATAGTGTGGGGCCAGGAAGGGAAAAGTCACTGATAAAAGAAC
TTCTGTAGATATGTCATTTAAAACTGTGAGAAAACAACATGAAAAGATGCCTGAACTCTCCATCCTGAGGAAAGATTAGCACTTCTGATG
AAAATCACAGTCTGTCAAAGGTATTAAAAGAAAACTTTAAAAAAAAAAACCTTTAGAAACGTTGAACTAATGTACACTGAGAAAAACCAT
ATAACTTACTTATAGACATATAATTACATGATCCTCTCTTACTACAACTGAGGCTAACACATGGTAAAATGGTTCCCAAATCAAGCCAGT
TATGTCATTAAATACTTGTCTTTCAGAATTACTTATTTAATTATTCCATTTAAGTTCATATAATATAATCTACAGTTTAGATACTTGGAC
ATATATCCTGCCCAAGGCACTAAGTGTAATATAGGAAAAGGATAGAAAGCCATTTTCTCTATCTTCAAAATAATGTGCCATCTCCGTTAA
AATTAAGACTTTAAAGTTCTATAATTTTTTCTTTGTATTCAACTTTTTAATACCTCCAAATTACAAACATCTATTTTTTTCACTACATAG
ATATATAATTACACTATGATAGACAGAATTCTAGAGTGATTCTCAATAATCCATGCCTTGGTATAATCCTCTCCCCCATTGAGTGTGGGT
GGGACATGTAACCTGCTTCTAACCAACAGAATATGGCAAAAGTGATGGGATCATCTCTCCCATATTATGTTATGTTATATAACAAAAGTG
AAGAGAAGTTGCAGATATACATAAGGTTTCTAATCAGCTGACTTTGAGTTAATCAAAGAGATCCCCTGGGTGGGCCTGACCTAATCAGAC
TAGTCCTTTAAAAGAGAGTGAACCAGTCAGAGACTCTCTCTCCTATTAGCCTTAAATAAGCAAGCTGCCATGAGCTCTACGGCTGCAAGG
AAATAAGTTTTGTGAACAACCATGTGATCTTGGAAGAAGCATCTGAACCTCAGATAAAAGCCCAGCCCCAGCCAACGCCTTGCTTGCAGC
TTTGTGAAACTCTGAGCAGAGGACCCAGCTAAATCACGTTTGGACTCCTGACCCACAGAAACTTTCAGATAATAAATGTATGCTGTTTTA

>99017_99017_7_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000453925_VEPH1_chr3_157099165_ENST00000392833_length(amino acids)=756AA_BP=270
MTINWAELLSGCHKCCHILEHKLHQGDWVRQVTYNASLDAIISSTTSNTNSVVMAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATA
GINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISF
NNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVK
ERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEET
KLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEI
DPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVP
DQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEK
ATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTY

--------------------------------------------------------------
>99017_99017_8_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000453925_VEPH1_chr3_157099165_ENST00000543418_length(transcript)=3698nt_BP=845nt
GGCCTGCTAGTGCATGTGAAGATGGAGAAGCCACTATGACCATTAACTGGGCAGAGCTGCTCTCTGGATGTCACAAATGTTGCCATATAT
TAGAGCATAAACTTCATCAAGGAGATTGGGTCAGGCAAGTTACTTACAATGCATCTTTAGACGCTATCATTTCCAGTACAACCAGCAATA
CAAATAGTGTGGTGATGGCTTGGAGAGAGAAATCAAAAAAGCGTCTTAATATGACATCCTTCAACATTGCCCAGGGCATTCATGCTTTTG
ATTATCACTCTCGGCTCAATTTAATTGCAACTGCTGGCATTAACAATAAAGTTTGCCTTTGGAATCCCTATGTTGTCTCTAAACCAGTGG
GTGTCCTTTGGGGCCACTCAGCCAGTGTAATAGCCGTCCAATTCTTTGTGGAAAGAAAACAACTTTTCAGCTTCTCCAAGGATAAAGTTT
TGAGACTCTGGGATATTCAACACCAGCTGTCCATCCAGAGGATAGCTTGTTCTTTCCCCAAAAGTCAGGACTTCAGATGTCTCTTCCACT
TTGATGAAGCCCATGGACGACTTTTCATCTCGTTTAATAACCAGCTAGCATTGTTGGCAATGAAAAGTGAAGCCAGCAAGAGGGTGAAAA
GCCATGAGAAAGCAGTCACTTGTGTTCTTTACAATTCTATCTTGAAGCAGGTAATCAGCTCTGATACAGGGTCTACTGTTTCCTTCTGGA
TGATAGACACTGGGCAGAAAATCAAACAGTTTACTGGTTGCCACGGCAACGCAGAAATCAGCACTATGGCCCTTGATGCAAATGAGACTC
GGCTTTTGACTGGCAGCACAGATGGGACTGTAAAGGAGAGAGCCAGGAGCTGCCTGACATACCTGGTGAGCCAACTGGCCAACATGGAGC
ATTCGTTTCACCATATTCTCCTGCTGGAGATTAAAAGCATCACCGACACCTTCTCCTCAATCTTGGGCCCTCAGAGCAGAGACATCTTCC
GCATGAGCAACAGCTTCACCGCCATTGCTAAACTCCTTACCCGACAACTGGAAAATACCAAGGCTGGAAGTGGCAGGAGAAAAATCAGCA
CTGAAATTGAATTCCCTGAGAAACTGGAAGAAACCAAGCTCATAGTAACTGAAAATGAAGACCATGAAAAACTCCAAGTTAAAATCCAGG
CTTTTGAAGACAAGATAAATGCAGGGAGCAATACCCCTGGCTCTATCAGAAGATATAGTCTGGGCCAAGTTTCTAAAGAAGAAAGAAAAA
ACATTAGATTTAACAGGTCAAAAAGTTTGGCTTTCCACACTATGCTCACAAAGGGTGTGGGTTCAGATGACGGCGAAGATGAAAACAGGG
GAGACATACCAGCCAGCATCTCTCTTTCAGAAATAGACCCACTTGGCCAAGGAAATGACAAGCTGCCGTTTAAGACAGACACTGAGAGAT
CACAGCTGGGGGAGTCTTCAGTTTCATACCCAAATATTATACATATAGACTCAGAGAATTTGTCAGAAACTGTTAAAGAAAACTCCCAGG
AAGAAACTCCAGAGACAACTGCAAGTCCTATAGAATACCAAGATAAGCTCTACTTGCACTTAAAAAAAAACCTCAGCAAAGTGAAAGCAT
ATGCCATGGAAATTGGAAAGAAGATTCCAGTCCCTGATCAGTGTACCATTGAAGACACTGTGAGAAGTTGTGTAGCAAAGTTGTTCTTCA
CCTGCTCCCTGAAGGGTCATTACTGCCTATACAGTAAGTCCAGTTTTATTCTCATCAGCCAAGAACCTCAGCCATGGATCCAGATCATGT
TTCTATTTCAGCAGGATCTGGACCAGGTACAGCTCCATCTGGAAGAAGTGAGGTTCTTTGACGTGTTTGGCTTCAGTGAAACAGCAGGAG
CATGGCAATGCTTCATGTGCAACAATCCTGAGAAAGCAACTGTTGTAAATCAAGATGGCCAGCCTCTCATAGAAGGAAAACTTAAAGAGA
AGCAAGTCAGATGGAAGTTCATCAAAAGGTGGAAAACACGCTATTTTACACTGGCTGGAAATCAACTTCTGTTTCAAAAAGGAAAGTCTA
AAGATGACCCTGACGACTGCCCAATAGAACTCAGCAAAGTACAGAGTGTGAAGGCTGTGGCCAAGAAACGCAGGGACCGCTCTCTCCCCC
GGGCTTTCGAAATCTTCACAGACAATAAAACCTATGTCTTTAAGGCCAAGGATGAGAAGAATGCAGAAGAATGGCTCCAGTGCATCAACG
TGGCAGTTGCCCAAGCCAAAGAAAGGGAAAGTAGAGAAGTAACCACATATCTGTAGGGATTTATAAGTCAGCCATGACAATTATACACCA
CAGGCATTGTATTATCATTGCCAATGTCAAGAAAAAGAGCTAAATTTACCAAGCCATGTTGTTTTTTACTAAATACCAATGGAATTGTTG
TCCTTTAAGAAGAAGGGCCTAAAATGGCAGGATTCTTAGTAAATGTCATACTCTAACAGCTTTAGTATTGACTTCAGAATATATCTGATG
CCCACAAAAATAAAATAAAATAAAAGGAGCTACAGAGTATGCCCTCAGATAGTGTGGGGCCAGGAAGGGAAAAGTCACTGATAAAAGAAC
TTCTGTAGATATGTCATTTAAAACTGTGAGAAAACAACATGAAAAGATGCCTGAACTCTCCATCCTGAGGAAAGATTAGCACTTCTGATG
AAAATCACAGTCTGTCAAAGGTATTAAAAGAAAACTTTAAAAAAAAAAACCTTTAGAAACGTTGAACTAATGTACACTGAGAAAAACCAT
ATAACTTACTTATAGACATATAATTACATGATCCTCTCTTACTACAACTGAGGCTAACACATGGTAAAATGGTTCCCAAATCAAGCCAGT
TATGTCATTAAATACTTGTCTTTCAGAATTACTTATTTAATTATTCCATTTAAGTTCATATAATATAATCTACAGTTTAGATACTTGGAC
ATATATCCTGCCCAAGGCACTAAGTGTAATATAGGAAAAGGATAGAAAGCCATTTTCTCTATCTTCAAAATAATGTGCCATCTCCGTTAA
AATTAAGACTTTAAAGTTCTATAATTTTTTCTTTGTATTCAACTTTTTAATACCTCCAAATTACAAACATCTATTTTTTTCACTACATAG
ATATATAATTACACTATGATAGACAGAATTCTAGAGTGATTCTCAATAATCCATGCCTTGGTATAATCCTCTCCCCCATTGAGTGTGGGT
GGGACATGTAACCTGCTTCTAACCAACAGAATATGGCAAAAGTGATGGGATCATCTCTCCCATATTATGTTATGTTATATAACAAAAGTG
AAGAGAAGTTGCAGATATACATAAGGTTTCTAATCAGCTGACTTTGAGTTAATCAAAGAGATCCCCTGGGTGGGCCTGACCTAATCAGAC
TAGTCCTTTAAAAGAGAGTGAACCAGTCAGAGACTCTCTCTCCTATTAGCCTTAAATAAGCAAGCTGCCATGAGCTCTACGGCTGCAAGG
AAATAAGTTTTGTGAACAACCATGTGATCTTGGAAGAAGCATCTGAACCTCAGATAAAAGCCCAGCCCCAGCCAACGCCTTGCTTGCAGC
TTTGTGAAACTCTGAGCAGAGGACCCAGCTAAATCACGTTTGGACTCCTGACCCACAGAAACTTTCAGATAATAAATGTATGCTGTTTTA

>99017_99017_8_WDR49-VEPH1_WDR49_chr3_167277852_ENST00000453925_VEPH1_chr3_157099165_ENST00000543418_length(amino acids)=756AA_BP=270
MTINWAELLSGCHKCCHILEHKLHQGDWVRQVTYNASLDAIISSTTSNTNSVVMAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATA
GINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISF
NNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVK
ERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEET
KLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEI
DPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVP
DQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEK
ATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for WDR49-VEPH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneVEPH1chr3:167277852chr3:157099165ENST00000362010514663_833302.0834.0TGFBR1
TgeneVEPH1chr3:167277852chr3:157099165ENST00000392832514663_833302.0834.0TGFBR1
TgeneVEPH1chr3:167277852chr3:157099165ENST00000392833513663_833302.0789.0TGFBR1
TgeneVEPH1chr3:167277852chr3:157099165ENST0000046823304201_3190214.0TGFBR1
TgeneVEPH1chr3:167277852chr3:157099165ENST0000046823304663_8330214.0TGFBR1
TgeneVEPH1chr3:167277852chr3:157099165ENST0000049467705201_3190214.0TGFBR1
TgeneVEPH1chr3:167277852chr3:157099165ENST0000049467705663_8330214.0TGFBR1
TgeneVEPH1chr3:167277852chr3:157099165ENST0000053755904201_3190178.0TGFBR1
TgeneVEPH1chr3:167277852chr3:157099165ENST0000053755904663_8330178.0TGFBR1
TgeneVEPH1chr3:167277852chr3:157099165ENST00000543418513663_833302.0789.0TGFBR1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneVEPH1chr3:167277852chr3:157099165ENST00000362010514201_319302.0834.0TGFBR1
TgeneVEPH1chr3:167277852chr3:157099165ENST00000392832514201_319302.0834.0TGFBR1
TgeneVEPH1chr3:167277852chr3:157099165ENST00000392833513201_319302.0789.0TGFBR1
TgeneVEPH1chr3:167277852chr3:157099165ENST00000543418513201_319302.0789.0TGFBR1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WDR49-VEPH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WDR49-VEPH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource