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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WDR60-VIPR2 (FusionGDB2 ID:99043)

Fusion Gene Summary for WDR60-VIPR2

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR60-VIPR2
Fusion gene ID: 99043
HgeneTgene
Gene symbol

WDR60

VIPR2

Gene ID

55112

7434

Gene nameWD repeat domain 60vasoactive intestinal peptide receptor 2
SynonymsCFAP163|DIC6|FAP163|SRPS6|SRTD8C16DUPq36.3|DUP7q36.3|PACAP-R-3|PACAP-R3|VIP-R-2|VPAC2|VPAC2R|VPCAP2R
Cytomap

7q36.3

7q36.3

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 60testicular secretory protein Li 66vasoactive intestinal polypeptide receptor 2PACAP type III receptorVIP and PACAP receptor 2helodermin-preferring VIP receptorpituitary adenylate cyclase-activating polypeptide type III receptor
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000407559, ENST00000421760, 
ENST00000262178, ENST00000377633, 
ENST00000402066, 
Fusion gene scores* DoF score5 X 7 X 3=1055 X 5 X 5=125
# samples 67
** MAII scorelog2(6/105*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/125*10)=-0.836501267717121
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR60 [Title/Abstract] AND VIPR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDR60(158694507)-VIPR2(158851269), # samples:2
WDR60(158684024)-VIPR2(158851269), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across WDR60 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VIPR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-A3-3363-01AWDR60chr7

158684024

-VIPR2chr7

158851269

-
ChimerDB4KIRCTCGA-A3-3363-01AWDR60chr7

158684024

+VIPR2chr7

158851269

-
ChimerDB4KIRCTCGA-A3-3363-01AWDR60chr7

158694507

+VIPR2chr7

158851269

-


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Fusion Gene ORF analysis for WDR60-VIPR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000407559ENST00000421760WDR60chr7

158684024

+VIPR2chr7

158851269

-
5CDS-intronENST00000407559ENST00000421760WDR60chr7

158694507

+VIPR2chr7

158851269

-
In-frameENST00000407559ENST00000262178WDR60chr7

158684024

+VIPR2chr7

158851269

-
In-frameENST00000407559ENST00000262178WDR60chr7

158694507

+VIPR2chr7

158851269

-
In-frameENST00000407559ENST00000377633WDR60chr7

158684024

+VIPR2chr7

158851269

-
In-frameENST00000407559ENST00000377633WDR60chr7

158694507

+VIPR2chr7

158851269

-
In-frameENST00000407559ENST00000402066WDR60chr7

158684024

+VIPR2chr7

158851269

-
In-frameENST00000407559ENST00000402066WDR60chr7

158694507

+VIPR2chr7

158851269

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000407559WDR60chr7158694507+ENST00000262178VIPR2chr7158851269-46961295352254739
ENST00000407559WDR60chr7158694507+ENST00000377633VIPR2chr7158851269-24161295352254739
ENST00000407559WDR60chr7158694507+ENST00000402066VIPR2chr7158851269-23531295352254739
ENST00000407559WDR60chr7158684024+ENST00000262178VIPR2chr7158851269-46181217352176713
ENST00000407559WDR60chr7158684024+ENST00000377633VIPR2chr7158851269-23381217352176713
ENST00000407559WDR60chr7158684024+ENST00000402066VIPR2chr7158851269-22751217352176713

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000407559ENST00000262178WDR60chr7158694507+VIPR2chr7158851269-0.0010694620.9989305
ENST00000407559ENST00000377633WDR60chr7158694507+VIPR2chr7158851269-0.0020268960.99797314
ENST00000407559ENST00000402066WDR60chr7158694507+VIPR2chr7158851269-0.0022593960.9977406
ENST00000407559ENST00000262178WDR60chr7158684024+VIPR2chr7158851269-0.0012224540.99877757
ENST00000407559ENST00000377633WDR60chr7158684024+VIPR2chr7158851269-0.0023884720.9976115
ENST00000407559ENST00000402066WDR60chr7158684024+VIPR2chr7158851269-0.0026706860.99732935

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Fusion Genomic Features for WDR60-VIPR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WDR60-VIPR2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:158694507/chr7:158851269)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313152_158119439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313179_203119439.0Topological domainExtracellular
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313228_240119439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313263_279119439.0Topological domainExtracellular
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313304_328119439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313349_360119439.0Topological domainExtracellular
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313381_438119439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313152_158119439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313179_203119439.0Topological domainExtracellular
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313228_240119439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313263_279119439.0Topological domainExtracellular
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313304_328119439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313349_360119439.0Topological domainExtracellular
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313381_438119439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313127_151119439.0TransmembraneHelical%3B Name%3D1
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313159_178119439.0TransmembraneHelical%3B Name%3D2
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313204_227119439.0TransmembraneHelical%3B Name%3D3
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313241_262119439.0TransmembraneHelical%3B Name%3D4
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313280_303119439.0TransmembraneHelical%3B Name%3D5
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313329_348119439.0TransmembraneHelical%3B Name%3D6
TgeneVIPR2chr7:158684024chr7:158851269ENST00000262178313361_380119439.0TransmembraneHelical%3B Name%3D7
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313127_151119439.0TransmembraneHelical%3B Name%3D1
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313159_178119439.0TransmembraneHelical%3B Name%3D2
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313204_227119439.0TransmembraneHelical%3B Name%3D3
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313241_262119439.0TransmembraneHelical%3B Name%3D4
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313280_303119439.0TransmembraneHelical%3B Name%3D5
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313329_348119439.0TransmembraneHelical%3B Name%3D6
TgeneVIPR2chr7:158694507chr7:158851269ENST00000262178313361_380119439.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR60chr7:158684024chr7:158851269ENST00000407559+825473_5523531067.0RegionBinding to the DYNLT2B-DYNLT1/DYNLT3 dimer
HgeneWDR60chr7:158694507chr7:158851269ENST00000407559+925473_5523791067.0RegionBinding to the DYNLT2B-DYNLT1/DYNLT3 dimer
HgeneWDR60chr7:158684024chr7:158851269ENST00000407559+825694_7343531067.0RepeatWD 1
HgeneWDR60chr7:158684024chr7:158851269ENST00000407559+825775_8213531067.0RepeatWD 2
HgeneWDR60chr7:158684024chr7:158851269ENST00000407559+825907_9473531067.0RepeatWD 3
HgeneWDR60chr7:158684024chr7:158851269ENST00000407559+825952_9923531067.0RepeatWD 4
HgeneWDR60chr7:158694507chr7:158851269ENST00000407559+925694_7343791067.0RepeatWD 1
HgeneWDR60chr7:158694507chr7:158851269ENST00000407559+925775_8213791067.0RepeatWD 2
HgeneWDR60chr7:158694507chr7:158851269ENST00000407559+925907_9473791067.0RepeatWD 3
HgeneWDR60chr7:158694507chr7:158851269ENST00000407559+925952_9923791067.0RepeatWD 4
TgeneVIPR2chr7:158684024chr7:158851269ENST0000026217831324_126119439.0Topological domainExtracellular
TgeneVIPR2chr7:158694507chr7:158851269ENST0000026217831324_126119439.0Topological domainExtracellular


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Fusion Gene Sequence for WDR60-VIPR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99043_99043_1_WDR60-VIPR2_WDR60_chr7_158684024_ENST00000407559_VIPR2_chr7_158851269_ENST00000262178_length(transcript)=4618nt_BP=1217nt
CTGGGCAGTGCTTCTGGGCCCTCTGCTGCTCCTGCTTGTCGGTTGCTAGGCGCTGGGACGCGCCTCCCGAAGGGTGCGGGGCACAGGTGG
CCTCTTCGGGGTGGACCGCGCCTGGCCGGGGCCGAGGACACCGCGGCCGCCCGGGCCTGCGGGAAGCGATGGAGCCCGGGAAGAGAAGAA
CCAAAGATGATACCTGGAAAGCAGATGACCTCAGAAAACATCTCTGGGCCATACAGTCAGGTGGTTCCAAGGAAGAAAGAAAGCACAGAG
AGAAGAAGCTGCGTAAGGAGTCTGAGATGGACCTTCCTGAACATAAGGAGCCGAGGTGCAGGGATCCCGACCAGGATGCCAGGAGCAGAG
ACAGGGTGGCCGAAGTCCACACCGCTAAGGAGAGTCCTCGTGGGGAGAGGGACAGAGACAGACAGAGGGAGAGGAGAAGAGACGCAAAAG
ACCGGGAGAAAGAAAAGCTGAAGGAGAAACATCGAGAGGCAGAAAAGTCTCACAGCAGAGGAAAGGACAGGGAAAAAGAAAAAGACAGAA
GGGCCCGGAAGGAAGAGCTCCGGCAGACCGTGGCCCACCACAACCTGCTGGGCCAGGAGACACGCGACCGGCAGCTCCTGGAGCGGGCGG
AGAGGAAAGGCCGCTCAGTAAGTAAAGTAAGAAGTGAAGAGAAAGATGAAGACTCTGAAAGAGGAGATGAAGATAGAGAAAGAAGATACC
GAGAAAGAAAGCTGCAGTACGGAGACAGCAAGGACAACCCTCTCAAGTACTGGCTTTATAAAGAAGAAGGCGAGAGGAGACACAGGAAGC
CCAGAGAGCCAGATCGAGACAACAAACACCGAGAAAAAAGCAGCACAAGGGAAAAAAGAGAGAAATATTCCAAAGAGAAAAGTAATTCAT
TCTCTGACAAAGGGGAAGAAAGACATAAAGAAAAGCGACACAAAGAAGGTTTTCATTTTGATGATGAGAGGCACCAAAGCAACGTGGATA
GAAAAGAGAAATCGGCAAAAGATGAGCCCAGGAAAAGGGAATCCCAGAATGGTGAACACAGAAATCGAGGTGCAAGCTCAAAAAGAGATG
GGACCAGCAGCCAGCATGCTGAGAATTTAGTAAGGAATCATGGAAAAGATAAAGATTCAAGACGGAAGCATGGCCACGAGGAAGGCTCTT
CTGTGTGGTGGAAGCTGGACCAGAGGCCGGGAGGCGAGGAAACCGTGATCACGTTTTATATTCTGGTGAAGGCCATTTATACACTGGGCT
ACAGTGTCTCTCTGATGTCTCTTGCAACAGGAAGCATAATTCTGTGCCTCTTCAGGAAGCTGCACTGCACCAGGAATTACATCCACCTGA
ACCTGTTCCTGTCCTTCATCCTGAGAGCCATCTCAGTGCTGGTCAAGGACGACGTTCTCTACTCCAGCTCTGGCACGTTGCACTGCCCTG
ACCAGCCATCCTCCTGGGTGGGCTGCAAGCTGAGCCTGGTCTTCCTGCAGTACTGCATCATGGCCAACTTCTTCTGGCTGCTGGTGGAGG
GGCTCTACCTCCACACCCTCCTGGTGGCCATGCTCCCCCCTAGAAGGTGCTTCCTGGCCTACCTCCTGATCGGATGGGGCCTCCCCACCG
TCTGCATCGGTGCATGGACTGCGGCCAGGCTCTACTTAGAAGACACCGGTTGCTGGGATACAAACGACCACAGTGTGCCCTGGTGGGTCA
TACGAATACCGATTTTAATTTCCATCATCGTCAATTTTGTCCTTTTCATTAGTATTATACGAATTTTGCTGCAGAAGTTAACATCCCCAG
ATGTCGGCGGCAACGACCAGTCTCAGTACAAGAGGCTGGCCAAGTCCACGCTCCTGCTTATCCCGCTGTTCGGCGTCCACTACATGGTGT
TTGCCGTGTTTCCCATCAGCATCTCCTCCAAATACCAGATACTGTTTGAGCTGTGCCTCGGGTCGTTCCAGGGCCTGGTGGTGGCCGTCC
TCTACTGTTTCCTGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCCGTCCGCGAGCCGGGATTACA
GGGTCTGCGGTTCCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGCCCAGTCCTTCCTGCAAACGG
AGACCTCGGTCATCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGCGGGGCTGAGACGCCGGCTTC
CTCCTTCCAGATGCCCGAGCACCGTGTCGGGCAGGTCAGCGCGGTCCTGACTCCGTCAAGCTGGTTGTCCACTAAACCCCATACCTGGAA
TTGGAGTCGTGTTGTCATTGACTCGATTTAAACTCCAGCATTTAGATAATCTTGTGCAAAATGTGTTTCAGCCGTATAGTGGATCCACTT
TTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGACTGCAGTGGCCTGATCTCTGCTCCCTGCAAGCTCCGC
CTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCATAGCTGGGACTACAGGCGCCCGCCAACACGCCTGGCTAATTTTTTGTATTTT
TAGTAGAGACAGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATGGGCCCGCCTCGGCCTCCCAAAGTGCTGGG
ATTAAGGCGTGAGCCACTGCGCCCGGCCCAAGAGAATAGGGGAGCCAAGGAGGAAATGTGGAAACGCAGTTGTGTGGCCCAGCACGAGCC
TGGGCGACCACCGGGTGACATCCGTCCCACATCAGGGCGGCCTCCCAGGTCCCATAAGGGTAGCCCCCTCATCTGCAGGACAGAGGGAAG
CCAGTCAGGGCCCCCCTGACGTTAGGACCAGGAGAAATCAACAGGAGGGCAGCCCGTCCTCTCTCTTGGGGCGCCCACCCGGCCCGGCTG
AGCCCTGCCCCACCCAACTCCACAGGGCTGTTTTGCCTCCCCACGGAAGGCGGGCTGAGGAGACAACCAGATCAGGAGAGCAAGGTCATG
AAGGAGGGGACCTCTCCACACAGGTGTTCCGTGGGACCCTCAGCAGCTCTGGCTCTGCCTCAGGAGGTCACCTGCCGCCCTGTGGGAGCC
GCAGAGCCTGACGCTCAGCCCCAGGCCAGCTGCGGCCAGGCCTGCGGGCCCCTGGTGATGGGGTTACGTGGGGTGCGGGATACAGCTGAG
TGGGAACCGGAAACCTATTCTCTTTTTAACAAAAATAATCTTAGGATAAGAATTATTTTAACAACATATAAAACTGTTTCAAGCCCTCCT
CCCCAGAGCTGGCGCTCAGCAGCCCTAGCGGCTGCTCCTTCAGGCGAAGGGTGGTTTGCAGATGTGGGGAGGGTGTCTGGGGACGTTGCT
GAGCCAGCTGCAGAAGGGTGGGGATATCAGGGCACAGTCTCCATGTGTGTGCCAAGCCCTGGCCCCCACAGCGCTCGATGGACCTCAGCA
AGCTGCCCAGCCCTGGCCCAGGTGCCCCGACTGTGGGACTCAGTTGTTCTGAGCACATTTGACTCCACTTTTCCCTTAAAAATGAATGTC
TTGTTCCTGTGCATTGGTGGCATCACAGACCCCAGCTGGGGCGCGATGTCAAAGGTCGGGACAGCTGTGCCGGGAGGCAGCCACAGGGAA
GCTCACACATCCTGTCAGTGTCACCTTGGTTTGCAAAACCCATATCCCCGGTAAAATGAGGCCGGACAGAGGGGCTGTTAGGACAGCAAA
GCAGCAGTGTCCAGAGACCCCTCAATCCCCAAAGGTCCGCACCCTGTCCTGCACACCCTGGGCCACGCCGGCCACACCCCTCTGCTGCAA
CAAGCTCATCCCTGGACTTCTGGGAGAATGAACCCGAGGTTGGTTTGGGGAGACAGGTGAGGCGGTCGGATCTACAGAACAACCCACCAT
TTCTGGGGGCCGCAGAGGATCCATCACAGACGGATACTGGGGAGTAAACGGCCCAGGCCAGGTGCCCAGGAAAGGACGGCTGAGCATGTG
GAGCGAGAGGGAGGCAGGTGGACGCTGCAGACCCCAGGTTCAGTGCGGCCCCTCGGCTGTTCCTCCCCTGTAGGGTTTGGACAGACCCAC
CCCCAGCCTTGCCCAGCTTTCAAAGGACAAAAGGGAGCATCCCCCACCTACTCTCAGGTTTTTGAGGAAACAAAGATTTGTGGTAACTGA
AGGTGTTGGGTCAGTGGCCAGGTGCCGACACTGAGCTGTGACCCAGAGGGGACGCTGAGGAAGTGGGCGTGAGTGGACGTGTCAGGTGGT
TACCAGGCACTGGTTGTTGATGGTCGGTGGTTGGGTGTGGGCAGTCATCAGTCATCAGGTGTGCTCAGGGGACAATCTCCCCTCAACCGC
ACATGTGCCACTGTTCAGCGGAGCTGACTGGTTTCTCCTGGTAGAGGGGCCGGCTGTTTCCTGACAGATGCCTGGTGAGCAGGGGAAGCA
GGACCCAGTGGTCAGCAGGTGTCTTTAACTGTCATTGTGTGTGGAATGTCGCAGACTCCTCCACGTGGCGGGAATGAGCTGTGTAAATAC

>99043_99043_1_WDR60-VIPR2_WDR60_chr7_158684024_ENST00000407559_VIPR2_chr7_158851269_ENST00000262178_length(amino acids)=713AA_BP=394
MSVARRWDAPPEGCGAQVASSGWTAPGRGRGHRGRPGLREAMEPGKRRTKDDTWKADDLRKHLWAIQSGGSKEERKHREKKLRKESEMDL
PEHKEPRCRDPDQDARSRDRVAEVHTAKESPRGERDRDRQRERRRDAKDREKEKLKEKHREAEKSHSRGKDREKEKDRRARKEELRQTVA
HHNLLGQETRDRQLLERAERKGRSVSKVRSEEKDEDSERGDEDRERRYRERKLQYGDSKDNPLKYWLYKEEGERRHRKPREPDRDNKHRE
KSSTREKREKYSKEKSNSFSDKGEERHKEKRHKEGFHFDDERHQSNVDRKEKSAKDEPRKRESQNGEHRNRGASSKRDGTSSQHAENLVR
NHGKDKDSRRKHGHEEGSSVWWKLDQRPGGEETVITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAIS
VLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLY
LEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKY

--------------------------------------------------------------
>99043_99043_2_WDR60-VIPR2_WDR60_chr7_158684024_ENST00000407559_VIPR2_chr7_158851269_ENST00000377633_length(transcript)=2338nt_BP=1217nt
CTGGGCAGTGCTTCTGGGCCCTCTGCTGCTCCTGCTTGTCGGTTGCTAGGCGCTGGGACGCGCCTCCCGAAGGGTGCGGGGCACAGGTGG
CCTCTTCGGGGTGGACCGCGCCTGGCCGGGGCCGAGGACACCGCGGCCGCCCGGGCCTGCGGGAAGCGATGGAGCCCGGGAAGAGAAGAA
CCAAAGATGATACCTGGAAAGCAGATGACCTCAGAAAACATCTCTGGGCCATACAGTCAGGTGGTTCCAAGGAAGAAAGAAAGCACAGAG
AGAAGAAGCTGCGTAAGGAGTCTGAGATGGACCTTCCTGAACATAAGGAGCCGAGGTGCAGGGATCCCGACCAGGATGCCAGGAGCAGAG
ACAGGGTGGCCGAAGTCCACACCGCTAAGGAGAGTCCTCGTGGGGAGAGGGACAGAGACAGACAGAGGGAGAGGAGAAGAGACGCAAAAG
ACCGGGAGAAAGAAAAGCTGAAGGAGAAACATCGAGAGGCAGAAAAGTCTCACAGCAGAGGAAAGGACAGGGAAAAAGAAAAAGACAGAA
GGGCCCGGAAGGAAGAGCTCCGGCAGACCGTGGCCCACCACAACCTGCTGGGCCAGGAGACACGCGACCGGCAGCTCCTGGAGCGGGCGG
AGAGGAAAGGCCGCTCAGTAAGTAAAGTAAGAAGTGAAGAGAAAGATGAAGACTCTGAAAGAGGAGATGAAGATAGAGAAAGAAGATACC
GAGAAAGAAAGCTGCAGTACGGAGACAGCAAGGACAACCCTCTCAAGTACTGGCTTTATAAAGAAGAAGGCGAGAGGAGACACAGGAAGC
CCAGAGAGCCAGATCGAGACAACAAACACCGAGAAAAAAGCAGCACAAGGGAAAAAAGAGAGAAATATTCCAAAGAGAAAAGTAATTCAT
TCTCTGACAAAGGGGAAGAAAGACATAAAGAAAAGCGACACAAAGAAGGTTTTCATTTTGATGATGAGAGGCACCAAAGCAACGTGGATA
GAAAAGAGAAATCGGCAAAAGATGAGCCCAGGAAAAGGGAATCCCAGAATGGTGAACACAGAAATCGAGGTGCAAGCTCAAAAAGAGATG
GGACCAGCAGCCAGCATGCTGAGAATTTAGTAAGGAATCATGGAAAAGATAAAGATTCAAGACGGAAGCATGGCCACGAGGAAGGCTCTT
CTGTGTGGTGGAAGCTGGACCAGAGGCCGGGAGGCGAGGAAACCGTGATCACGTTTTATATTCTGGTGAAGGCCATTTATACACTGGGCT
ACAGTGTCTCTCTGATGTCTCTTGCAACAGGAAGCATAATTCTGTGCCTCTTCAGGAAGCTGCACTGCACCAGGAATTACATCCACCTGA
ACCTGTTCCTGTCCTTCATCCTGAGAGCCATCTCAGTGCTGGTCAAGGACGACGTTCTCTACTCCAGCTCTGGCACGTTGCACTGCCCTG
ACCAGCCATCCTCCTGGGTGGGCTGCAAGCTGAGCCTGGTCTTCCTGCAGTACTGCATCATGGCCAACTTCTTCTGGCTGCTGGTGGAGG
GGCTCTACCTCCACACCCTCCTGGTGGCCATGCTCCCCCCTAGAAGGTGCTTCCTGGCCTACCTCCTGATCGGATGGGGCCTCCCCACCG
TCTGCATCGGTGCATGGACTGCGGCCAGGCTCTACTTAGAAGACACCGGTTGCTGGGATACAAACGACCACAGTGTGCCCTGGTGGGTCA
TACGAATACCGATTTTAATTTCCATCATCGTCAATTTTGTCCTTTTCATTAGTATTATACGAATTTTGCTGCAGAAGTTAACATCCCCAG
ATGTCGGCGGCAACGACCAGTCTCAGTACAAGAGGCTGGCCAAGTCCACGCTCCTGCTTATCCCGCTGTTCGGCGTCCACTACATGGTGT
TTGCCGTGTTTCCCATCAGCATCTCCTCCAAATACCAGATACTGTTTGAGCTGTGCCTCGGGTCGTTCCAGGGCCTGGTGGTGGCCGTCC
TCTACTGTTTCCTGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCCGTCCGCGAGCCGGGATTACA
GGGTCTGCGGTTCCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGCCCAGTCCTTCCTGCAAACGG
AGACCTCGGTCATCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGCGGGGCTGAGACGCCGGCTTC

>99043_99043_2_WDR60-VIPR2_WDR60_chr7_158684024_ENST00000407559_VIPR2_chr7_158851269_ENST00000377633_length(amino acids)=713AA_BP=394
MSVARRWDAPPEGCGAQVASSGWTAPGRGRGHRGRPGLREAMEPGKRRTKDDTWKADDLRKHLWAIQSGGSKEERKHREKKLRKESEMDL
PEHKEPRCRDPDQDARSRDRVAEVHTAKESPRGERDRDRQRERRRDAKDREKEKLKEKHREAEKSHSRGKDREKEKDRRARKEELRQTVA
HHNLLGQETRDRQLLERAERKGRSVSKVRSEEKDEDSERGDEDRERRYRERKLQYGDSKDNPLKYWLYKEEGERRHRKPREPDRDNKHRE
KSSTREKREKYSKEKSNSFSDKGEERHKEKRHKEGFHFDDERHQSNVDRKEKSAKDEPRKRESQNGEHRNRGASSKRDGTSSQHAENLVR
NHGKDKDSRRKHGHEEGSSVWWKLDQRPGGEETVITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAIS
VLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLY
LEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKY

--------------------------------------------------------------
>99043_99043_3_WDR60-VIPR2_WDR60_chr7_158684024_ENST00000407559_VIPR2_chr7_158851269_ENST00000402066_length(transcript)=2275nt_BP=1217nt
CTGGGCAGTGCTTCTGGGCCCTCTGCTGCTCCTGCTTGTCGGTTGCTAGGCGCTGGGACGCGCCTCCCGAAGGGTGCGGGGCACAGGTGG
CCTCTTCGGGGTGGACCGCGCCTGGCCGGGGCCGAGGACACCGCGGCCGCCCGGGCCTGCGGGAAGCGATGGAGCCCGGGAAGAGAAGAA
CCAAAGATGATACCTGGAAAGCAGATGACCTCAGAAAACATCTCTGGGCCATACAGTCAGGTGGTTCCAAGGAAGAAAGAAAGCACAGAG
AGAAGAAGCTGCGTAAGGAGTCTGAGATGGACCTTCCTGAACATAAGGAGCCGAGGTGCAGGGATCCCGACCAGGATGCCAGGAGCAGAG
ACAGGGTGGCCGAAGTCCACACCGCTAAGGAGAGTCCTCGTGGGGAGAGGGACAGAGACAGACAGAGGGAGAGGAGAAGAGACGCAAAAG
ACCGGGAGAAAGAAAAGCTGAAGGAGAAACATCGAGAGGCAGAAAAGTCTCACAGCAGAGGAAAGGACAGGGAAAAAGAAAAAGACAGAA
GGGCCCGGAAGGAAGAGCTCCGGCAGACCGTGGCCCACCACAACCTGCTGGGCCAGGAGACACGCGACCGGCAGCTCCTGGAGCGGGCGG
AGAGGAAAGGCCGCTCAGTAAGTAAAGTAAGAAGTGAAGAGAAAGATGAAGACTCTGAAAGAGGAGATGAAGATAGAGAAAGAAGATACC
GAGAAAGAAAGCTGCAGTACGGAGACAGCAAGGACAACCCTCTCAAGTACTGGCTTTATAAAGAAGAAGGCGAGAGGAGACACAGGAAGC
CCAGAGAGCCAGATCGAGACAACAAACACCGAGAAAAAAGCAGCACAAGGGAAAAAAGAGAGAAATATTCCAAAGAGAAAAGTAATTCAT
TCTCTGACAAAGGGGAAGAAAGACATAAAGAAAAGCGACACAAAGAAGGTTTTCATTTTGATGATGAGAGGCACCAAAGCAACGTGGATA
GAAAAGAGAAATCGGCAAAAGATGAGCCCAGGAAAAGGGAATCCCAGAATGGTGAACACAGAAATCGAGGTGCAAGCTCAAAAAGAGATG
GGACCAGCAGCCAGCATGCTGAGAATTTAGTAAGGAATCATGGAAAAGATAAAGATTCAAGACGGAAGCATGGCCACGAGGAAGGCTCTT
CTGTGTGGTGGAAGCTGGACCAGAGGCCGGGAGGCGAGGAAACCGTGATCACGTTTTATATTCTGGTGAAGGCCATTTATACACTGGGCT
ACAGTGTCTCTCTGATGTCTCTTGCAACAGGAAGCATAATTCTGTGCCTCTTCAGGAAGCTGCACTGCACCAGGAATTACATCCACCTGA
ACCTGTTCCTGTCCTTCATCCTGAGAGCCATCTCAGTGCTGGTCAAGGACGACGTTCTCTACTCCAGCTCTGGCACGTTGCACTGCCCTG
ACCAGCCATCCTCCTGGGTGGGCTGCAAGCTGAGCCTGGTCTTCCTGCAGTACTGCATCATGGCCAACTTCTTCTGGCTGCTGGTGGAGG
GGCTCTACCTCCACACCCTCCTGGTGGCCATGCTCCCCCCTAGAAGGTGCTTCCTGGCCTACCTCCTGATCGGATGGGGCCTCCCCACCG
TCTGCATCGGTGCATGGACTGCGGCCAGGCTCTACTTAGAAGACACCGGTTGCTGGGATACAAACGACCACAGTGTGCCCTGGTGGGTCA
TACGAATACCGATTTTAATTTCCATCATCGTCAATTTTGTCCTTTTCATTAGTATTATACGAATTTTGCTGCAGAAGTTAACATCCCCAG
ATGTCGGCGGCAACGACCAGTCTCAGTACAAGAGGCTGGCCAAGTCCACGCTCCTGCTTATCCCGCTGTTCGGCGTCCACTACATGGTGT
TTGCCGTGTTTCCCATCAGCATCTCCTCCAAATACCAGATACTGTTTGAGCTGTGCCTCGGGTCGTTCCAGGGCCTGGTGGTGGCCGTCC
TCTACTGTTTCCTGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCCGTCCGCGAGCCGGGATTACA
GGGTCTGCGGTTCCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGCCCAGTCCTTCCTGCAAACGG
AGACCTCGGTCATCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGCGGGGCTGAGACGCCGGCTTC

>99043_99043_3_WDR60-VIPR2_WDR60_chr7_158684024_ENST00000407559_VIPR2_chr7_158851269_ENST00000402066_length(amino acids)=713AA_BP=394
MSVARRWDAPPEGCGAQVASSGWTAPGRGRGHRGRPGLREAMEPGKRRTKDDTWKADDLRKHLWAIQSGGSKEERKHREKKLRKESEMDL
PEHKEPRCRDPDQDARSRDRVAEVHTAKESPRGERDRDRQRERRRDAKDREKEKLKEKHREAEKSHSRGKDREKEKDRRARKEELRQTVA
HHNLLGQETRDRQLLERAERKGRSVSKVRSEEKDEDSERGDEDRERRYRERKLQYGDSKDNPLKYWLYKEEGERRHRKPREPDRDNKHRE
KSSTREKREKYSKEKSNSFSDKGEERHKEKRHKEGFHFDDERHQSNVDRKEKSAKDEPRKRESQNGEHRNRGASSKRDGTSSQHAENLVR
NHGKDKDSRRKHGHEEGSSVWWKLDQRPGGEETVITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAIS
VLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLY
LEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKY

--------------------------------------------------------------
>99043_99043_4_WDR60-VIPR2_WDR60_chr7_158694507_ENST00000407559_VIPR2_chr7_158851269_ENST00000262178_length(transcript)=4696nt_BP=1295nt
CTGGGCAGTGCTTCTGGGCCCTCTGCTGCTCCTGCTTGTCGGTTGCTAGGCGCTGGGACGCGCCTCCCGAAGGGTGCGGGGCACAGGTGG
CCTCTTCGGGGTGGACCGCGCCTGGCCGGGGCCGAGGACACCGCGGCCGCCCGGGCCTGCGGGAAGCGATGGAGCCCGGGAAGAGAAGAA
CCAAAGATGATACCTGGAAAGCAGATGACCTCAGAAAACATCTCTGGGCCATACAGTCAGGTGGTTCCAAGGAAGAAAGAAAGCACAGAG
AGAAGAAGCTGCGTAAGGAGTCTGAGATGGACCTTCCTGAACATAAGGAGCCGAGGTGCAGGGATCCCGACCAGGATGCCAGGAGCAGAG
ACAGGGTGGCCGAAGTCCACACCGCTAAGGAGAGTCCTCGTGGGGAGAGGGACAGAGACAGACAGAGGGAGAGGAGAAGAGACGCAAAAG
ACCGGGAGAAAGAAAAGCTGAAGGAGAAACATCGAGAGGCAGAAAAGTCTCACAGCAGAGGAAAGGACAGGGAAAAAGAAAAAGACAGAA
GGGCCCGGAAGGAAGAGCTCCGGCAGACCGTGGCCCACCACAACCTGCTGGGCCAGGAGACACGCGACCGGCAGCTCCTGGAGCGGGCGG
AGAGGAAAGGCCGCTCAGTAAGTAAAGTAAGAAGTGAAGAGAAAGATGAAGACTCTGAAAGAGGAGATGAAGATAGAGAAAGAAGATACC
GAGAAAGAAAGCTGCAGTACGGAGACAGCAAGGACAACCCTCTCAAGTACTGGCTTTATAAAGAAGAAGGCGAGAGGAGACACAGGAAGC
CCAGAGAGCCAGATCGAGACAACAAACACCGAGAAAAAAGCAGCACAAGGGAAAAAAGAGAGAAATATTCCAAAGAGAAAAGTAATTCAT
TCTCTGACAAAGGGGAAGAAAGACATAAAGAAAAGCGACACAAAGAAGGTTTTCATTTTGATGATGAGAGGCACCAAAGCAACGTGGATA
GAAAAGAGAAATCGGCAAAAGATGAGCCCAGGAAAAGGGAATCCCAGAATGGTGAACACAGAAATCGAGGTGCAAGCTCAAAAAGAGATG
GGACCAGCAGCCAGCATGCTGAGAATTTAGTAAGGAATCATGGAAAAGATAAAGATTCAAGACGGAAGCATGGCCACGAGGAAGGCTCTT
CTGTGTGGTGGAAGCTGGACCAGAGGCCGGGAGGCGAGGAAACCGTGGAAATTGAAAAGGAAGAAACTGATTTAGAAAATGCTAGAGCTG
ATGCATATACAGCCAGTTGTGAAGATGATTTTGAAATCACGTTTTATATTCTGGTGAAGGCCATTTATACACTGGGCTACAGTGTCTCTC
TGATGTCTCTTGCAACAGGAAGCATAATTCTGTGCCTCTTCAGGAAGCTGCACTGCACCAGGAATTACATCCACCTGAACCTGTTCCTGT
CCTTCATCCTGAGAGCCATCTCAGTGCTGGTCAAGGACGACGTTCTCTACTCCAGCTCTGGCACGTTGCACTGCCCTGACCAGCCATCCT
CCTGGGTGGGCTGCAAGCTGAGCCTGGTCTTCCTGCAGTACTGCATCATGGCCAACTTCTTCTGGCTGCTGGTGGAGGGGCTCTACCTCC
ACACCCTCCTGGTGGCCATGCTCCCCCCTAGAAGGTGCTTCCTGGCCTACCTCCTGATCGGATGGGGCCTCCCCACCGTCTGCATCGGTG
CATGGACTGCGGCCAGGCTCTACTTAGAAGACACCGGTTGCTGGGATACAAACGACCACAGTGTGCCCTGGTGGGTCATACGAATACCGA
TTTTAATTTCCATCATCGTCAATTTTGTCCTTTTCATTAGTATTATACGAATTTTGCTGCAGAAGTTAACATCCCCAGATGTCGGCGGCA
ACGACCAGTCTCAGTACAAGAGGCTGGCCAAGTCCACGCTCCTGCTTATCCCGCTGTTCGGCGTCCACTACATGGTGTTTGCCGTGTTTC
CCATCAGCATCTCCTCCAAATACCAGATACTGTTTGAGCTGTGCCTCGGGTCGTTCCAGGGCCTGGTGGTGGCCGTCCTCTACTGTTTCC
TGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCCGTCCGCGAGCCGGGATTACAGGGTCTGCGGTT
CCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGCCCAGTCCTTCCTGCAAACGGAGACCTCGGTCA
TCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGCGGGGCTGAGACGCCGGCTTCCTCCTTCCAGAT
GCCCGAGCACCGTGTCGGGCAGGTCAGCGCGGTCCTGACTCCGTCAAGCTGGTTGTCCACTAAACCCCATACCTGGAATTGGAGTCGTGT
TGTCATTGACTCGATTTAAACTCCAGCATTTAGATAATCTTGTGCAAAATGTGTTTCAGCCGTATAGTGGATCCACTTTTTTTTTTTTTT
TTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGACTGCAGTGGCCTGATCTCTGCTCCCTGCAAGCTCCGCCTCCCGGGTTCA
CGCCATTCTCCTGCCTCAGCCTCCCATAGCTGGGACTACAGGCGCCCGCCAACACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACAG
GGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATGGGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTAAGGCGTGA
GCCACTGCGCCCGGCCCAAGAGAATAGGGGAGCCAAGGAGGAAATGTGGAAACGCAGTTGTGTGGCCCAGCACGAGCCTGGGCGACCACC
GGGTGACATCCGTCCCACATCAGGGCGGCCTCCCAGGTCCCATAAGGGTAGCCCCCTCATCTGCAGGACAGAGGGAAGCCAGTCAGGGCC
CCCCTGACGTTAGGACCAGGAGAAATCAACAGGAGGGCAGCCCGTCCTCTCTCTTGGGGCGCCCACCCGGCCCGGCTGAGCCCTGCCCCA
CCCAACTCCACAGGGCTGTTTTGCCTCCCCACGGAAGGCGGGCTGAGGAGACAACCAGATCAGGAGAGCAAGGTCATGAAGGAGGGGACC
TCTCCACACAGGTGTTCCGTGGGACCCTCAGCAGCTCTGGCTCTGCCTCAGGAGGTCACCTGCCGCCCTGTGGGAGCCGCAGAGCCTGAC
GCTCAGCCCCAGGCCAGCTGCGGCCAGGCCTGCGGGCCCCTGGTGATGGGGTTACGTGGGGTGCGGGATACAGCTGAGTGGGAACCGGAA
ACCTATTCTCTTTTTAACAAAAATAATCTTAGGATAAGAATTATTTTAACAACATATAAAACTGTTTCAAGCCCTCCTCCCCAGAGCTGG
CGCTCAGCAGCCCTAGCGGCTGCTCCTTCAGGCGAAGGGTGGTTTGCAGATGTGGGGAGGGTGTCTGGGGACGTTGCTGAGCCAGCTGCA
GAAGGGTGGGGATATCAGGGCACAGTCTCCATGTGTGTGCCAAGCCCTGGCCCCCACAGCGCTCGATGGACCTCAGCAAGCTGCCCAGCC
CTGGCCCAGGTGCCCCGACTGTGGGACTCAGTTGTTCTGAGCACATTTGACTCCACTTTTCCCTTAAAAATGAATGTCTTGTTCCTGTGC
ATTGGTGGCATCACAGACCCCAGCTGGGGCGCGATGTCAAAGGTCGGGACAGCTGTGCCGGGAGGCAGCCACAGGGAAGCTCACACATCC
TGTCAGTGTCACCTTGGTTTGCAAAACCCATATCCCCGGTAAAATGAGGCCGGACAGAGGGGCTGTTAGGACAGCAAAGCAGCAGTGTCC
AGAGACCCCTCAATCCCCAAAGGTCCGCACCCTGTCCTGCACACCCTGGGCCACGCCGGCCACACCCCTCTGCTGCAACAAGCTCATCCC
TGGACTTCTGGGAGAATGAACCCGAGGTTGGTTTGGGGAGACAGGTGAGGCGGTCGGATCTACAGAACAACCCACCATTTCTGGGGGCCG
CAGAGGATCCATCACAGACGGATACTGGGGAGTAAACGGCCCAGGCCAGGTGCCCAGGAAAGGACGGCTGAGCATGTGGAGCGAGAGGGA
GGCAGGTGGACGCTGCAGACCCCAGGTTCAGTGCGGCCCCTCGGCTGTTCCTCCCCTGTAGGGTTTGGACAGACCCACCCCCAGCCTTGC
CCAGCTTTCAAAGGACAAAAGGGAGCATCCCCCACCTACTCTCAGGTTTTTGAGGAAACAAAGATTTGTGGTAACTGAAGGTGTTGGGTC
AGTGGCCAGGTGCCGACACTGAGCTGTGACCCAGAGGGGACGCTGAGGAAGTGGGCGTGAGTGGACGTGTCAGGTGGTTACCAGGCACTG
GTTGTTGATGGTCGGTGGTTGGGTGTGGGCAGTCATCAGTCATCAGGTGTGCTCAGGGGACAATCTCCCCTCAACCGCACATGTGCCACT
GTTCAGCGGAGCTGACTGGTTTCTCCTGGTAGAGGGGCCGGCTGTTTCCTGACAGATGCCTGGTGAGCAGGGGAAGCAGGACCCAGTGGT
CAGCAGGTGTCTTTAACTGTCATTGTGTGTGGAATGTCGCAGACTCCTCCACGTGGCGGGAATGAGCTGTGTAAATACTTCAATAAAGCC

>99043_99043_4_WDR60-VIPR2_WDR60_chr7_158694507_ENST00000407559_VIPR2_chr7_158851269_ENST00000262178_length(amino acids)=739AA_BP=420
MSVARRWDAPPEGCGAQVASSGWTAPGRGRGHRGRPGLREAMEPGKRRTKDDTWKADDLRKHLWAIQSGGSKEERKHREKKLRKESEMDL
PEHKEPRCRDPDQDARSRDRVAEVHTAKESPRGERDRDRQRERRRDAKDREKEKLKEKHREAEKSHSRGKDREKEKDRRARKEELRQTVA
HHNLLGQETRDRQLLERAERKGRSVSKVRSEEKDEDSERGDEDRERRYRERKLQYGDSKDNPLKYWLYKEEGERRHRKPREPDRDNKHRE
KSSTREKREKYSKEKSNSFSDKGEERHKEKRHKEGFHFDDERHQSNVDRKEKSAKDEPRKRESQNGEHRNRGASSKRDGTSSQHAENLVR
NHGKDKDSRRKHGHEEGSSVWWKLDQRPGGEETVEIEKEETDLENARADAYTASCEDDFEITFYILVKAIYTLGYSVSLMSLATGSIILC
LFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRR
CFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKS
TLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGAL

--------------------------------------------------------------
>99043_99043_5_WDR60-VIPR2_WDR60_chr7_158694507_ENST00000407559_VIPR2_chr7_158851269_ENST00000377633_length(transcript)=2416nt_BP=1295nt
CTGGGCAGTGCTTCTGGGCCCTCTGCTGCTCCTGCTTGTCGGTTGCTAGGCGCTGGGACGCGCCTCCCGAAGGGTGCGGGGCACAGGTGG
CCTCTTCGGGGTGGACCGCGCCTGGCCGGGGCCGAGGACACCGCGGCCGCCCGGGCCTGCGGGAAGCGATGGAGCCCGGGAAGAGAAGAA
CCAAAGATGATACCTGGAAAGCAGATGACCTCAGAAAACATCTCTGGGCCATACAGTCAGGTGGTTCCAAGGAAGAAAGAAAGCACAGAG
AGAAGAAGCTGCGTAAGGAGTCTGAGATGGACCTTCCTGAACATAAGGAGCCGAGGTGCAGGGATCCCGACCAGGATGCCAGGAGCAGAG
ACAGGGTGGCCGAAGTCCACACCGCTAAGGAGAGTCCTCGTGGGGAGAGGGACAGAGACAGACAGAGGGAGAGGAGAAGAGACGCAAAAG
ACCGGGAGAAAGAAAAGCTGAAGGAGAAACATCGAGAGGCAGAAAAGTCTCACAGCAGAGGAAAGGACAGGGAAAAAGAAAAAGACAGAA
GGGCCCGGAAGGAAGAGCTCCGGCAGACCGTGGCCCACCACAACCTGCTGGGCCAGGAGACACGCGACCGGCAGCTCCTGGAGCGGGCGG
AGAGGAAAGGCCGCTCAGTAAGTAAAGTAAGAAGTGAAGAGAAAGATGAAGACTCTGAAAGAGGAGATGAAGATAGAGAAAGAAGATACC
GAGAAAGAAAGCTGCAGTACGGAGACAGCAAGGACAACCCTCTCAAGTACTGGCTTTATAAAGAAGAAGGCGAGAGGAGACACAGGAAGC
CCAGAGAGCCAGATCGAGACAACAAACACCGAGAAAAAAGCAGCACAAGGGAAAAAAGAGAGAAATATTCCAAAGAGAAAAGTAATTCAT
TCTCTGACAAAGGGGAAGAAAGACATAAAGAAAAGCGACACAAAGAAGGTTTTCATTTTGATGATGAGAGGCACCAAAGCAACGTGGATA
GAAAAGAGAAATCGGCAAAAGATGAGCCCAGGAAAAGGGAATCCCAGAATGGTGAACACAGAAATCGAGGTGCAAGCTCAAAAAGAGATG
GGACCAGCAGCCAGCATGCTGAGAATTTAGTAAGGAATCATGGAAAAGATAAAGATTCAAGACGGAAGCATGGCCACGAGGAAGGCTCTT
CTGTGTGGTGGAAGCTGGACCAGAGGCCGGGAGGCGAGGAAACCGTGGAAATTGAAAAGGAAGAAACTGATTTAGAAAATGCTAGAGCTG
ATGCATATACAGCCAGTTGTGAAGATGATTTTGAAATCACGTTTTATATTCTGGTGAAGGCCATTTATACACTGGGCTACAGTGTCTCTC
TGATGTCTCTTGCAACAGGAAGCATAATTCTGTGCCTCTTCAGGAAGCTGCACTGCACCAGGAATTACATCCACCTGAACCTGTTCCTGT
CCTTCATCCTGAGAGCCATCTCAGTGCTGGTCAAGGACGACGTTCTCTACTCCAGCTCTGGCACGTTGCACTGCCCTGACCAGCCATCCT
CCTGGGTGGGCTGCAAGCTGAGCCTGGTCTTCCTGCAGTACTGCATCATGGCCAACTTCTTCTGGCTGCTGGTGGAGGGGCTCTACCTCC
ACACCCTCCTGGTGGCCATGCTCCCCCCTAGAAGGTGCTTCCTGGCCTACCTCCTGATCGGATGGGGCCTCCCCACCGTCTGCATCGGTG
CATGGACTGCGGCCAGGCTCTACTTAGAAGACACCGGTTGCTGGGATACAAACGACCACAGTGTGCCCTGGTGGGTCATACGAATACCGA
TTTTAATTTCCATCATCGTCAATTTTGTCCTTTTCATTAGTATTATACGAATTTTGCTGCAGAAGTTAACATCCCCAGATGTCGGCGGCA
ACGACCAGTCTCAGTACAAGAGGCTGGCCAAGTCCACGCTCCTGCTTATCCCGCTGTTCGGCGTCCACTACATGGTGTTTGCCGTGTTTC
CCATCAGCATCTCCTCCAAATACCAGATACTGTTTGAGCTGTGCCTCGGGTCGTTCCAGGGCCTGGTGGTGGCCGTCCTCTACTGTTTCC
TGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCCGTCCGCGAGCCGGGATTACAGGGTCTGCGGTT
CCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGCCCAGTCCTTCCTGCAAACGGAGACCTCGGTCA
TCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGCGGGGCTGAGACGCCGGCTTCCTCCTTCCAGAT

>99043_99043_5_WDR60-VIPR2_WDR60_chr7_158694507_ENST00000407559_VIPR2_chr7_158851269_ENST00000377633_length(amino acids)=739AA_BP=420
MSVARRWDAPPEGCGAQVASSGWTAPGRGRGHRGRPGLREAMEPGKRRTKDDTWKADDLRKHLWAIQSGGSKEERKHREKKLRKESEMDL
PEHKEPRCRDPDQDARSRDRVAEVHTAKESPRGERDRDRQRERRRDAKDREKEKLKEKHREAEKSHSRGKDREKEKDRRARKEELRQTVA
HHNLLGQETRDRQLLERAERKGRSVSKVRSEEKDEDSERGDEDRERRYRERKLQYGDSKDNPLKYWLYKEEGERRHRKPREPDRDNKHRE
KSSTREKREKYSKEKSNSFSDKGEERHKEKRHKEGFHFDDERHQSNVDRKEKSAKDEPRKRESQNGEHRNRGASSKRDGTSSQHAENLVR
NHGKDKDSRRKHGHEEGSSVWWKLDQRPGGEETVEIEKEETDLENARADAYTASCEDDFEITFYILVKAIYTLGYSVSLMSLATGSIILC
LFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRR
CFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKS
TLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGAL

--------------------------------------------------------------
>99043_99043_6_WDR60-VIPR2_WDR60_chr7_158694507_ENST00000407559_VIPR2_chr7_158851269_ENST00000402066_length(transcript)=2353nt_BP=1295nt
CTGGGCAGTGCTTCTGGGCCCTCTGCTGCTCCTGCTTGTCGGTTGCTAGGCGCTGGGACGCGCCTCCCGAAGGGTGCGGGGCACAGGTGG
CCTCTTCGGGGTGGACCGCGCCTGGCCGGGGCCGAGGACACCGCGGCCGCCCGGGCCTGCGGGAAGCGATGGAGCCCGGGAAGAGAAGAA
CCAAAGATGATACCTGGAAAGCAGATGACCTCAGAAAACATCTCTGGGCCATACAGTCAGGTGGTTCCAAGGAAGAAAGAAAGCACAGAG
AGAAGAAGCTGCGTAAGGAGTCTGAGATGGACCTTCCTGAACATAAGGAGCCGAGGTGCAGGGATCCCGACCAGGATGCCAGGAGCAGAG
ACAGGGTGGCCGAAGTCCACACCGCTAAGGAGAGTCCTCGTGGGGAGAGGGACAGAGACAGACAGAGGGAGAGGAGAAGAGACGCAAAAG
ACCGGGAGAAAGAAAAGCTGAAGGAGAAACATCGAGAGGCAGAAAAGTCTCACAGCAGAGGAAAGGACAGGGAAAAAGAAAAAGACAGAA
GGGCCCGGAAGGAAGAGCTCCGGCAGACCGTGGCCCACCACAACCTGCTGGGCCAGGAGACACGCGACCGGCAGCTCCTGGAGCGGGCGG
AGAGGAAAGGCCGCTCAGTAAGTAAAGTAAGAAGTGAAGAGAAAGATGAAGACTCTGAAAGAGGAGATGAAGATAGAGAAAGAAGATACC
GAGAAAGAAAGCTGCAGTACGGAGACAGCAAGGACAACCCTCTCAAGTACTGGCTTTATAAAGAAGAAGGCGAGAGGAGACACAGGAAGC
CCAGAGAGCCAGATCGAGACAACAAACACCGAGAAAAAAGCAGCACAAGGGAAAAAAGAGAGAAATATTCCAAAGAGAAAAGTAATTCAT
TCTCTGACAAAGGGGAAGAAAGACATAAAGAAAAGCGACACAAAGAAGGTTTTCATTTTGATGATGAGAGGCACCAAAGCAACGTGGATA
GAAAAGAGAAATCGGCAAAAGATGAGCCCAGGAAAAGGGAATCCCAGAATGGTGAACACAGAAATCGAGGTGCAAGCTCAAAAAGAGATG
GGACCAGCAGCCAGCATGCTGAGAATTTAGTAAGGAATCATGGAAAAGATAAAGATTCAAGACGGAAGCATGGCCACGAGGAAGGCTCTT
CTGTGTGGTGGAAGCTGGACCAGAGGCCGGGAGGCGAGGAAACCGTGGAAATTGAAAAGGAAGAAACTGATTTAGAAAATGCTAGAGCTG
ATGCATATACAGCCAGTTGTGAAGATGATTTTGAAATCACGTTTTATATTCTGGTGAAGGCCATTTATACACTGGGCTACAGTGTCTCTC
TGATGTCTCTTGCAACAGGAAGCATAATTCTGTGCCTCTTCAGGAAGCTGCACTGCACCAGGAATTACATCCACCTGAACCTGTTCCTGT
CCTTCATCCTGAGAGCCATCTCAGTGCTGGTCAAGGACGACGTTCTCTACTCCAGCTCTGGCACGTTGCACTGCCCTGACCAGCCATCCT
CCTGGGTGGGCTGCAAGCTGAGCCTGGTCTTCCTGCAGTACTGCATCATGGCCAACTTCTTCTGGCTGCTGGTGGAGGGGCTCTACCTCC
ACACCCTCCTGGTGGCCATGCTCCCCCCTAGAAGGTGCTTCCTGGCCTACCTCCTGATCGGATGGGGCCTCCCCACCGTCTGCATCGGTG
CATGGACTGCGGCCAGGCTCTACTTAGAAGACACCGGTTGCTGGGATACAAACGACCACAGTGTGCCCTGGTGGGTCATACGAATACCGA
TTTTAATTTCCATCATCGTCAATTTTGTCCTTTTCATTAGTATTATACGAATTTTGCTGCAGAAGTTAACATCCCCAGATGTCGGCGGCA
ACGACCAGTCTCAGTACAAGAGGCTGGCCAAGTCCACGCTCCTGCTTATCCCGCTGTTCGGCGTCCACTACATGGTGTTTGCCGTGTTTC
CCATCAGCATCTCCTCCAAATACCAGATACTGTTTGAGCTGTGCCTCGGGTCGTTCCAGGGCCTGGTGGTGGCCGTCCTCTACTGTTTCC
TGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCCGTCCGCGAGCCGGGATTACAGGGTCTGCGGTT
CCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGCCCAGTCCTTCCTGCAAACGGAGACCTCGGTCA
TCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGCGGGGCTGAGACGCCGGCTTCCTCCTTCCAGAT

>99043_99043_6_WDR60-VIPR2_WDR60_chr7_158694507_ENST00000407559_VIPR2_chr7_158851269_ENST00000402066_length(amino acids)=739AA_BP=420
MSVARRWDAPPEGCGAQVASSGWTAPGRGRGHRGRPGLREAMEPGKRRTKDDTWKADDLRKHLWAIQSGGSKEERKHREKKLRKESEMDL
PEHKEPRCRDPDQDARSRDRVAEVHTAKESPRGERDRDRQRERRRDAKDREKEKLKEKHREAEKSHSRGKDREKEKDRRARKEELRQTVA
HHNLLGQETRDRQLLERAERKGRSVSKVRSEEKDEDSERGDEDRERRYRERKLQYGDSKDNPLKYWLYKEEGERRHRKPREPDRDNKHRE
KSSTREKREKYSKEKSNSFSDKGEERHKEKRHKEGFHFDDERHQSNVDRKEKSAKDEPRKRESQNGEHRNRGASSKRDGTSSQHAENLVR
NHGKDKDSRRKHGHEEGSSVWWKLDQRPGGEETVEIEKEETDLENARADAYTASCEDDFEITFYILVKAIYTLGYSVSLMSLATGSIILC
LFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRR
CFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKS
TLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGAL

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Fusion Gene PPI Analysis for WDR60-VIPR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WDR60-VIPR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WDR60-VIPR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource