FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:WDR6-CPNE8 (FusionGDB2 ID:99061)

Fusion Gene Summary for WDR6-CPNE8

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR6-CPNE8
Fusion gene ID: 99061
HgeneTgene
Gene symbol

WDR6

CPNE8

Gene ID

11180

144402

Gene nameWD repeat domain 6copine 8
Synonyms--
Cytomap

3p21.31

12q12

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 6copine-8copine VIII
Modification date2020032020200313
UniProtAcc.

Q86YQ8

Ensembl transtripts involved in fusion geneENST00000489684, ENST00000395474, 
ENST00000415265, ENST00000608424, 
ENST00000448293, 		ENST00000331366, 
ENST00000538596, ENST00000360449, 
ENST00000546603, 
Fusion gene scores* DoF score8 X 4 X 5=1607 X 5 X 6=210
# samples 87
** MAII scorelog2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR6 [Title/Abstract] AND CPNE8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDR6(49044964)-CPNE8(39047872), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWDR6

GO:0007050

cell cycle arrest

17216128

HgeneWDR6

GO:0008285

negative regulation of cell proliferation

17216128


check buttonFusion gene breakpoints across WDR6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CPNE8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-AA4T-01AWDR6chr3

49044964

-CPNE8chr12

39047872

-
ChimerDB4BLCATCGA-ZF-AA4T-01AWDR6chr3

49044964

+CPNE8chr12

39047872

-


Top

Fusion Gene ORF analysis for WDR6-CPNE8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000489684ENST00000331366WDR6chr3

49044964

+CPNE8chr12

39047872

-
3UTR-3CDSENST00000489684ENST00000538596WDR6chr3

49044964

+CPNE8chr12

39047872

-
3UTR-5UTRENST00000489684ENST00000360449WDR6chr3

49044964

+CPNE8chr12

39047872

-
3UTR-5UTRENST00000489684ENST00000546603WDR6chr3

49044964

+CPNE8chr12

39047872

-
5CDS-5UTRENST00000395474ENST00000360449WDR6chr3

49044964

+CPNE8chr12

39047872

-
5CDS-5UTRENST00000395474ENST00000546603WDR6chr3

49044964

+CPNE8chr12

39047872

-
5CDS-5UTRENST00000415265ENST00000360449WDR6chr3

49044964

+CPNE8chr12

39047872

-
5CDS-5UTRENST00000415265ENST00000546603WDR6chr3

49044964

+CPNE8chr12

39047872

-
5CDS-5UTRENST00000608424ENST00000360449WDR6chr3

49044964

+CPNE8chr12

39047872

-
5CDS-5UTRENST00000608424ENST00000546603WDR6chr3

49044964

+CPNE8chr12

39047872

-
Frame-shiftENST00000395474ENST00000538596WDR6chr3

49044964

+CPNE8chr12

39047872

-
Frame-shiftENST00000415265ENST00000538596WDR6chr3

49044964

+CPNE8chr12

39047872

-
Frame-shiftENST00000608424ENST00000538596WDR6chr3

49044964

+CPNE8chr12

39047872

-
In-frameENST00000395474ENST00000331366WDR6chr3

49044964

+CPNE8chr12

39047872

-
In-frameENST00000415265ENST00000331366WDR6chr3

49044964

+CPNE8chr12

39047872

-
In-frameENST00000608424ENST00000331366WDR6chr3

49044964

+CPNE8chr12

39047872

-
intron-3CDSENST00000448293ENST00000331366WDR6chr3

49044964

+CPNE8chr12

39047872

-
intron-3CDSENST00000448293ENST00000538596WDR6chr3

49044964

+CPNE8chr12

39047872

-
intron-5UTRENST00000448293ENST00000360449WDR6chr3

49044964

+CPNE8chr12

39047872

-
intron-5UTRENST00000448293ENST00000546603WDR6chr3

49044964

+CPNE8chr12

39047872

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395474WDR6chr349044964+ENST00000331366CPNE8chr1239047872-235647021338105
ENST00000608424WDR6chr349044964+ENST00000331366CPNE8chr1239047872-20251391459122378
ENST00000415265WDR6chr349044964+ENST00000331366CPNE8chr1239047872-20221361456122078

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395474ENST00000331366WDR6chr349044964+CPNE8chr1239047872-0.90042580.09957422
ENST00000608424ENST00000331366WDR6chr349044964+CPNE8chr1239047872-0.9866240.013376013
ENST00000415265ENST00000331366WDR6chr349044964+CPNE8chr1239047872-0.99120590.008794114

Top

Fusion Genomic Features for WDR6-CPNE8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for WDR6-CPNE8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:49044964/chr12:39047872)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CPNE8

Q86YQ8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. {ECO:0000250|UniProtKB:Q99829}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+161036_1073631152.0RepeatNote=WD 18
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16105_143631152.0RepeatNote=WD 2
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+161079_1121631152.0RepeatNote=WD 19
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16147_189631152.0RepeatNote=WD 3
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16200_238631152.0RepeatNote=WD 4
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16247_285631152.0RepeatNote=WD 5
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16289_327631152.0RepeatNote=WD 6
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16335_376631152.0RepeatNote=WD 7
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16381_422631152.0RepeatNote=WD 8
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16425_470631152.0RepeatNote=WD 9
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16476_520631152.0RepeatNote=WD 10
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+1653_97631152.0RepeatNote=WD 1
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16559_598631152.0RepeatNote=WD 11
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16604_642631152.0RepeatNote=WD 12
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16645_684631152.0RepeatNote=WD 13
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16739_785631152.0RepeatNote=WD 14
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16848_893631152.0RepeatNote=WD 15
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16901_946631152.0RepeatNote=WD 16
HgeneWDR6chr3:49044964chr12:39047872ENST00000395474+16970_1012631152.0RepeatNote=WD 17
TgeneCPNE8chr3:49044964chr12:39047872ENST000003313661820142_265502565.0DomainC2 2
TgeneCPNE8chr3:49044964chr12:39047872ENST0000033136618201_133502565.0DomainC2 1
TgeneCPNE8chr3:49044964chr12:39047872ENST000003313661820309_510502565.0DomainVWFA


Top

Fusion Gene Sequence for WDR6-CPNE8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99061_99061_1_WDR6-CPNE8_WDR6_chr3_49044964_ENST00000395474_CPNE8_chr12_39047872_ENST00000331366_length(transcript)=2356nt_BP=470nt
TTTATTGTGTACTGACTCCATCTGCCCCGTCAAATAAAAAACCACAAGGTTCGAGCCGCCGGGCCCGACAAACTCCGGGTCGGCGAAACA
GAGTCCGCGATAGGTGCAGCGGGCTGGCAGCTGGGAGCGCCCCGCAAGCGTCACGTGAGGGGGCGAGGGGCGGGATGCCCCTCCGCGGGC
CCCGCCAATGATGAGCTGGATTGCGTGGGACGAAGGGTCGTCATTGGACAACCGCCGCGGGCGCCCTGGTCTCTGCTACCTGTAGCTGAG
GGCGCTGTTGATGGGCAGCGCGGCGCGCTGGGAAGGCTCGTTCTCGCGAGAGTTCAGCTCCCTTCTTAGCCGTGGCTGCCTCAGCACCTC
GAGGATCGACATGGACGCTCTCGAGGACTACGTTTGGCCGCGGGCAACCTCGGAGCTTATACTCCTCCCAGTGACGGGTCTGGAGTGCGT
GGGGGACCGGCTGTTGGCGGTTTGTGCCATTCAGGGATTATATTGACAGAAGTGGAAACCACATACTGAGCATGGCTAGATTGGCTAAAG
ATGTCCTAGCTGAGATCCCTGAGCAGTTTCTCTCCTATATGAGAGCCCGAGGAATCAAGCCATCACCTGCGCCTCCCCCATACACCCCAC
CTACACATGTGTTACAGACTCAAATATGACTGTGCTCTGAAATGCTAATGTCAACTACAAATCAAAAGTGCTGAGTTAATGCTTTGTGCC
TGGTGCTCTGTAATGAACCAGGCAATGAGATAGTTTTCTCAGTTTGGTTTCAGCAGTTAATGTGCTTTCTTGGATCCAAATTTAAATATC
TTCCTAAACCAAAACTGTAAATATGGTTGTTGCATGAGCAACAGAAAAAATTGTTTAAATGCTTGAAGCAAAGTATGGATGTCTTCTCTA
AATCTTTCTTTCTTTTTTTTTTTAACAGAAACAGCTAATTTCCAATGTATTGTTGGGAAAAAGCACAAACTGTGTTTTTAACTCAAATAT
TGTCTTCGACTGCTATGTGTATAGGAAAGCAGTCTCTGTATCAATGTTTACATGTTACTACTTTTTAAATTTCAATACTTTTATAACTGT
TCTTAAAAATAAGAGTTTTAAATACTGAATCCTTTGTCTTCTAAATTGCAATAGCTATAATCACAAGAGCAATATCTCTTTGAATGACTG
TCTGGACAAACACAATTGCAAATAAGGGAAGGGAAAAATGCTTTTCTATTTTTCAGTAACTGGATTGTCTTAAGAAACTACATCTGCTTA
ATAAACAATTTCTCAGCAATGTTTGCTGGGTATGGGAGTTTAAGCCCGGCAGATGTGTCTCCTGGTTGAACATGCATTTTTCATGGAGTT
TGGGTTCTAAATTTAGACTGCAGTTGGTTTGTATTTTGTAACACTAAGTAGAAATTATAAAAAGTCAAACATTGTGATCTATAAATGCAC
AGAAAATACTTTGTAAAAAGTAGCATCCTTATATAATAATGCTATTTAGAAAGACTGAAACCAAGACTATTTAACTGTGAACTATGTAGC
AGATGTTTTAAACTTTTTATTCCATTATATCTTGTCTAGATATTTTAATTCAAAGGGATACTGGCTCTCTTGATCGGAATTTCTTGTTAT
CACCATTCCACGTTGCCACACAAGGTGCACAGGCTGGAAGTCTTTTGTGAAATTCCCAGTTAAATATATACAACTATGTGACTTAGTGCA
CAACACATTTGTGAAATAACCTACTCCTATATACTGACCTGCCTGTCCACGAATAATTGTAAAGGGTTTTTGCATGTACAGTTTTTACAA
GAATTACAGTTTTGTGAAGTTGTGTCTAAATTAAAGCATTTCTTTAGAACAAATGGCCTTAAATTCTCACGGAATTCCTGGAAATGATTG
TGAATTGCCTTCAAATAATAGAAAAGTGTATTTATTTGTGTGTGTGTGTGTGTCAAAAATGTAACTGCTTTATAATATTTTTTCCTTACC
TATATATTCTATTTAATACTTGGTTTATTTCTACTGTACATTGTTTTCTTTGTCCCAAGTTGACCTAGGGTGACTTTTATAAGCATGAAA
CTATTTTACTGGAAAGAAAAATATATACATCCACATATCTAACAGTATCAATGTTATATAACTATGTAATAATTGTTGATTTTTAATTAT
GTATTAAAATCTTTAAATCATAACTATTTGCTTTGTACGTTTCATGTATGAATGACAATAGTTTGATGATTTCCTTTACTGATCTTAAAT
ATTTATGCCACTACAGTGTATTACCTACAGATTTTTAAATTTAGCTTTATTTATCAACCCAAAAAACAAATAAATAAGATCAATATTCTT

>99061_99061_1_WDR6-CPNE8_WDR6_chr3_49044964_ENST00000395474_CPNE8_chr12_39047872_ENST00000331366_length(amino acids)=105AA_BP=
MPRQIKNHKVRAAGPDKLRVGETESAIGAAGWQLGAPRKRHVRGRGAGCPSAGPANDELDCVGRRVVIGQPPRAPWSLLPVAEGAVDGQR

--------------------------------------------------------------
>99061_99061_2_WDR6-CPNE8_WDR6_chr3_49044964_ENST00000415265_CPNE8_chr12_39047872_ENST00000331366_length(transcript)=2022nt_BP=136nt
CTTAGCCGTGGCTGCCTCAGCACCTCGAGGATCGACATGGACGCTCTCGAGGACTACGTTTGGCCGCGGGCAACCTCGGAGCTTATACTC
CTCCCAGTGACGGGTCTGGAGTGCGTGGGGGACCGGCTGTTGGCGGTTTGTGCCATTCAGGGATTATATTGACAGAAGTGGAAACCACAT
ACTGAGCATGGCTAGATTGGCTAAAGATGTCCTAGCTGAGATCCCTGAGCAGTTTCTCTCCTATATGAGAGCCCGAGGAATCAAGCCATC
ACCTGCGCCTCCCCCATACACCCCACCTACACATGTGTTACAGACTCAAATATGACTGTGCTCTGAAATGCTAATGTCAACTACAAATCA
AAAGTGCTGAGTTAATGCTTTGTGCCTGGTGCTCTGTAATGAACCAGGCAATGAGATAGTTTTCTCAGTTTGGTTTCAGCAGTTAATGTG
CTTTCTTGGATCCAAATTTAAATATCTTCCTAAACCAAAACTGTAAATATGGTTGTTGCATGAGCAACAGAAAAAATTGTTTAAATGCTT
GAAGCAAAGTATGGATGTCTTCTCTAAATCTTTCTTTCTTTTTTTTTTTAACAGAAACAGCTAATTTCCAATGTATTGTTGGGAAAAAGC
ACAAACTGTGTTTTTAACTCAAATATTGTCTTCGACTGCTATGTGTATAGGAAAGCAGTCTCTGTATCAATGTTTACATGTTACTACTTT
TTAAATTTCAATACTTTTATAACTGTTCTTAAAAATAAGAGTTTTAAATACTGAATCCTTTGTCTTCTAAATTGCAATAGCTATAATCAC
AAGAGCAATATCTCTTTGAATGACTGTCTGGACAAACACAATTGCAAATAAGGGAAGGGAAAAATGCTTTTCTATTTTTCAGTAACTGGA
TTGTCTTAAGAAACTACATCTGCTTAATAAACAATTTCTCAGCAATGTTTGCTGGGTATGGGAGTTTAAGCCCGGCAGATGTGTCTCCTG
GTTGAACATGCATTTTTCATGGAGTTTGGGTTCTAAATTTAGACTGCAGTTGGTTTGTATTTTGTAACACTAAGTAGAAATTATAAAAAG
TCAAACATTGTGATCTATAAATGCACAGAAAATACTTTGTAAAAAGTAGCATCCTTATATAATAATGCTATTTAGAAAGACTGAAACCAA
GACTATTTAACTGTGAACTATGTAGCAGATGTTTTAAACTTTTTATTCCATTATATCTTGTCTAGATATTTTAATTCAAAGGGATACTGG
CTCTCTTGATCGGAATTTCTTGTTATCACCATTCCACGTTGCCACACAAGGTGCACAGGCTGGAAGTCTTTTGTGAAATTCCCAGTTAAA
TATATACAACTATGTGACTTAGTGCACAACACATTTGTGAAATAACCTACTCCTATATACTGACCTGCCTGTCCACGAATAATTGTAAAG
GGTTTTTGCATGTACAGTTTTTACAAGAATTACAGTTTTGTGAAGTTGTGTCTAAATTAAAGCATTTCTTTAGAACAAATGGCCTTAAAT
TCTCACGGAATTCCTGGAAATGATTGTGAATTGCCTTCAAATAATAGAAAAGTGTATTTATTTGTGTGTGTGTGTGTGTCAAAAATGTAA
CTGCTTTATAATATTTTTTCCTTACCTATATATTCTATTTAATACTTGGTTTATTTCTACTGTACATTGTTTTCTTTGTCCCAAGTTGAC
CTAGGGTGACTTTTATAAGCATGAAACTATTTTACTGGAAAGAAAAATATATACATCCACATATCTAACAGTATCAATGTTATATAACTA
TGTAATAATTGTTGATTTTTAATTATGTATTAAAATCTTTAAATCATAACTATTTGCTTTGTACGTTTCATGTATGAATGACAATAGTTT
GATGATTTCCTTTACTGATCTTAAATATTTATGCCACTACAGTGTATTACCTACAGATTTTTAAATTTAGCTTTATTTATCAACCCAAAA

>99061_99061_2_WDR6-CPNE8_WDR6_chr3_49044964_ENST00000415265_CPNE8_chr12_39047872_ENST00000331366_length(amino acids)=78AA_BP=

--------------------------------------------------------------
>99061_99061_3_WDR6-CPNE8_WDR6_chr3_49044964_ENST00000608424_CPNE8_chr12_39047872_ENST00000331366_length(transcript)=2025nt_BP=139nt
CTTCTTAGCCGTGGCTGCCTCAGCACCTCGAGGATCGACATGGACGCTCTCGAGGACTACGTTTGGCCGCGGGCAACCTCGGAGCTTATA
CTCCTCCCAGTGACGGGTCTGGAGTGCGTGGGGGACCGGCTGTTGGCGGTTTGTGCCATTCAGGGATTATATTGACAGAAGTGGAAACCA
CATACTGAGCATGGCTAGATTGGCTAAAGATGTCCTAGCTGAGATCCCTGAGCAGTTTCTCTCCTATATGAGAGCCCGAGGAATCAAGCC
ATCACCTGCGCCTCCCCCATACACCCCACCTACACATGTGTTACAGACTCAAATATGACTGTGCTCTGAAATGCTAATGTCAACTACAAA
TCAAAAGTGCTGAGTTAATGCTTTGTGCCTGGTGCTCTGTAATGAACCAGGCAATGAGATAGTTTTCTCAGTTTGGTTTCAGCAGTTAAT
GTGCTTTCTTGGATCCAAATTTAAATATCTTCCTAAACCAAAACTGTAAATATGGTTGTTGCATGAGCAACAGAAAAAATTGTTTAAATG
CTTGAAGCAAAGTATGGATGTCTTCTCTAAATCTTTCTTTCTTTTTTTTTTTAACAGAAACAGCTAATTTCCAATGTATTGTTGGGAAAA
AGCACAAACTGTGTTTTTAACTCAAATATTGTCTTCGACTGCTATGTGTATAGGAAAGCAGTCTCTGTATCAATGTTTACATGTTACTAC
TTTTTAAATTTCAATACTTTTATAACTGTTCTTAAAAATAAGAGTTTTAAATACTGAATCCTTTGTCTTCTAAATTGCAATAGCTATAAT
CACAAGAGCAATATCTCTTTGAATGACTGTCTGGACAAACACAATTGCAAATAAGGGAAGGGAAAAATGCTTTTCTATTTTTCAGTAACT
GGATTGTCTTAAGAAACTACATCTGCTTAATAAACAATTTCTCAGCAATGTTTGCTGGGTATGGGAGTTTAAGCCCGGCAGATGTGTCTC
CTGGTTGAACATGCATTTTTCATGGAGTTTGGGTTCTAAATTTAGACTGCAGTTGGTTTGTATTTTGTAACACTAAGTAGAAATTATAAA
AAGTCAAACATTGTGATCTATAAATGCACAGAAAATACTTTGTAAAAAGTAGCATCCTTATATAATAATGCTATTTAGAAAGACTGAAAC
CAAGACTATTTAACTGTGAACTATGTAGCAGATGTTTTAAACTTTTTATTCCATTATATCTTGTCTAGATATTTTAATTCAAAGGGATAC
TGGCTCTCTTGATCGGAATTTCTTGTTATCACCATTCCACGTTGCCACACAAGGTGCACAGGCTGGAAGTCTTTTGTGAAATTCCCAGTT
AAATATATACAACTATGTGACTTAGTGCACAACACATTTGTGAAATAACCTACTCCTATATACTGACCTGCCTGTCCACGAATAATTGTA
AAGGGTTTTTGCATGTACAGTTTTTACAAGAATTACAGTTTTGTGAAGTTGTGTCTAAATTAAAGCATTTCTTTAGAACAAATGGCCTTA
AATTCTCACGGAATTCCTGGAAATGATTGTGAATTGCCTTCAAATAATAGAAAAGTGTATTTATTTGTGTGTGTGTGTGTGTCAAAAATG
TAACTGCTTTATAATATTTTTTCCTTACCTATATATTCTATTTAATACTTGGTTTATTTCTACTGTACATTGTTTTCTTTGTCCCAAGTT
GACCTAGGGTGACTTTTATAAGCATGAAACTATTTTACTGGAAAGAAAAATATATACATCCACATATCTAACAGTATCAATGTTATATAA
CTATGTAATAATTGTTGATTTTTAATTATGTATTAAAATCTTTAAATCATAACTATTTGCTTTGTACGTTTCATGTATGAATGACAATAG
TTTGATGATTTCCTTTACTGATCTTAAATATTTATGCCACTACAGTGTATTACCTACAGATTTTTAAATTTAGCTTTATTTATCAACCCA

>99061_99061_3_WDR6-CPNE8_WDR6_chr3_49044964_ENST00000608424_CPNE8_chr12_39047872_ENST00000331366_length(amino acids)=78AA_BP=

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for WDR6-CPNE8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for WDR6-CPNE8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for WDR6-CPNE8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource