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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WDR70-ADAMTS12 (FusionGDB2 ID:99068)

Fusion Gene Summary for WDR70-ADAMTS12

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR70-ADAMTS12
Fusion gene ID: 99068
HgeneTgene
Gene symbol

WDR70

ADAMTS12

Gene ID

55100

81792

Gene nameWD repeat domain 70ADAM metallopeptidase with thrombospondin type 1 motif 12
Synonyms-PRO4389
Cytomap

5p13.2

5p13.3-p13.2

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 70A disintegrin and metalloproteinase with thrombospondin motifs 12ADAM-TS 12ADAM-TS12ADAMTS-12a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12
Modification date2020031320200313
UniProtAcc.

P58397

Ensembl transtripts involved in fusion geneENST00000510699, ENST00000265107, 
ENST00000504564, 		ENST00000352040, 
ENST00000504830, ENST00000504582, 
ENST00000515401, 
Fusion gene scores* DoF score13 X 9 X 6=7029 X 7 X 7=441
# samples 139
** MAII scorelog2(13/702*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/441*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR70 [Title/Abstract] AND ADAMTS12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDR70(37605340)-ADAMTS12(33751653), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADAMTS12

GO:0030167

proteoglycan catabolic process

17895370

TgeneADAMTS12

GO:0032331

negative regulation of chondrocyte differentiation

22247065

TgeneADAMTS12

GO:0050727

regulation of inflammatory response

23019333

TgeneADAMTS12

GO:0051603

proteolysis involved in cellular protein catabolic process

16611630

TgeneADAMTS12

GO:0071773

cellular response to BMP stimulus

22247065

TgeneADAMTS12

GO:1901509

regulation of endothelial tube morphogenesis

17895370

TgeneADAMTS12

GO:1902203

negative regulation of hepatocyte growth factor receptor signaling pathway

17895370

TgeneADAMTS12

GO:1902548

negative regulation of cellular response to vascular endothelial growth factor stimulus

17895370

TgeneADAMTS12

GO:2001113

negative regulation of cellular response to hepatocyte growth factor stimulus

17895370


check buttonFusion gene breakpoints across WDR70 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADAMTS12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0SY-01AWDR70chr5

37605340

-ADAMTS12chr5

33751653

-
ChimerDB4BRCATCGA-A2-A0SY-01AWDR70chr5

37605340

+ADAMTS12chr5

33751653

-


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Fusion Gene ORF analysis for WDR70-ADAMTS12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000510699ENST00000352040WDR70chr5

37605340

+ADAMTS12chr5

33751653

-
3UTR-3CDSENST00000510699ENST00000504830WDR70chr5

37605340

+ADAMTS12chr5

33751653

-
3UTR-5UTRENST00000510699ENST00000504582WDR70chr5

37605340

+ADAMTS12chr5

33751653

-
3UTR-5UTRENST00000510699ENST00000515401WDR70chr5

37605340

+ADAMTS12chr5

33751653

-
5CDS-5UTRENST00000265107ENST00000504582WDR70chr5

37605340

+ADAMTS12chr5

33751653

-
5CDS-5UTRENST00000265107ENST00000515401WDR70chr5

37605340

+ADAMTS12chr5

33751653

-
5CDS-5UTRENST00000504564ENST00000504582WDR70chr5

37605340

+ADAMTS12chr5

33751653

-
5CDS-5UTRENST00000504564ENST00000515401WDR70chr5

37605340

+ADAMTS12chr5

33751653

-
In-frameENST00000265107ENST00000352040WDR70chr5

37605340

+ADAMTS12chr5

33751653

-
In-frameENST00000265107ENST00000504830WDR70chr5

37605340

+ADAMTS12chr5

33751653

-
In-frameENST00000504564ENST00000352040WDR70chr5

37605340

+ADAMTS12chr5

33751653

-
In-frameENST00000504564ENST00000504830WDR70chr5

37605340

+ADAMTS12chr5

33751653

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265107WDR70chr537605340+ENST00000504830ADAMTS12chr533751653-919712487855431821
ENST00000265107WDR70chr537605340+ENST00000352040ADAMTS12chr533751653-529612487852881736
ENST00000504564WDR70chr537605340+ENST00000504830ADAMTS12chr533751653-91241175554701821
ENST00000504564WDR70chr537605340+ENST00000352040ADAMTS12chr533751653-52231175552151736

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265107ENST00000504830WDR70chr537605340+ADAMTS12chr533751653-0.0002371790.99976283
ENST00000265107ENST00000352040WDR70chr537605340+ADAMTS12chr533751653-0.0006561110.99934393
ENST00000504564ENST00000504830WDR70chr537605340+ADAMTS12chr533751653-0.0002144710.9997855
ENST00000504564ENST00000352040WDR70chr537605340+ADAMTS12chr533751653-0.0005951080.9994049

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Fusion Genomic Features for WDR70-ADAMTS12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WDR70-ADAMTS12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:37605340/chr5:33751653)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ADAMTS12

P58397

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. {ECO:0000269|PubMed:16611630, ECO:0000269|PubMed:17895370, ECO:0000269|PubMed:18485748}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR70chr5:37605340chr5:33751653ENST00000265107+1018148_164364655.0Compositional biasNote=Glu-rich
HgeneWDR70chr5:37605340chr5:33751653ENST00000265107+101884_113364655.0Compositional biasNote=Ser-rich
HgeneWDR70chr5:37605340chr5:33751653ENST00000265107+1018180_219364655.0RepeatNote=WD 1
HgeneWDR70chr5:37605340chr5:33751653ENST00000265107+1018227_268364655.0RepeatNote=WD 2
HgeneWDR70chr5:37605340chr5:33751653ENST00000265107+1018281_321364655.0RepeatNote=WD 3
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000352040122302_3051631510.0Compositional biasNote=Poly-Glu
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000352040122597_7001631510.0Compositional biasNote=Cys-rich
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000504830124302_3051631595.0Compositional biasNote=Poly-Glu
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000504830124597_7001631595.0Compositional biasNote=Cys-rich
TgeneADAMTS12chr5:37605340chr5:33751653ENST000003520401221313_13661631510.0DomainTSP type-1 5
TgeneADAMTS12chr5:37605340chr5:33751653ENST000003520401221368_14221631510.0DomainTSP type-1 6
TgeneADAMTS12chr5:37605340chr5:33751653ENST000003520401221423_14711631510.0DomainTSP type-1 7
TgeneADAMTS12chr5:37605340chr5:33751653ENST000003520401221472_15321631510.0DomainTSP type-1 8
TgeneADAMTS12chr5:37605340chr5:33751653ENST000003520401221535_15751631510.0DomainPLAC
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000352040122246_4561631510.0DomainPeptidase M12B
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000352040122465_5441631510.0DomainNote=Disintegrin
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000352040122542_5971631510.0DomainTSP type-1 1
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000352040122823_8831631510.0DomainTSP type-1 2
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000352040122887_9431631510.0DomainTSP type-1 3
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000352040122944_9971631510.0DomainTSP type-1 4
TgeneADAMTS12chr5:37605340chr5:33751653ENST000005048301241313_13661631595.0DomainTSP type-1 5
TgeneADAMTS12chr5:37605340chr5:33751653ENST000005048301241368_14221631595.0DomainTSP type-1 6
TgeneADAMTS12chr5:37605340chr5:33751653ENST000005048301241423_14711631595.0DomainTSP type-1 7
TgeneADAMTS12chr5:37605340chr5:33751653ENST000005048301241472_15321631595.0DomainTSP type-1 8
TgeneADAMTS12chr5:37605340chr5:33751653ENST000005048301241535_15751631595.0DomainPLAC
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000504830124246_4561631595.0DomainPeptidase M12B
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000504830124465_5441631595.0DomainNote=Disintegrin
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000504830124542_5971631595.0DomainTSP type-1 1
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000504830124823_8831631595.0DomainTSP type-1 2
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000504830124887_9431631595.0DomainTSP type-1 3
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000504830124944_9971631595.0DomainTSP type-1 4
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000352040122208_2131631510.0MotifCysteine switch
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000504830124208_2131631595.0MotifCysteine switch
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000352040122701_8271631510.0RegionNote=Spacer 1
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000352040122997_13161631510.0RegionNote=Spacer 2
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000504830124701_8271631595.0RegionNote=Spacer 1
TgeneADAMTS12chr5:37605340chr5:33751653ENST00000504830124997_13161631595.0RegionNote=Spacer 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR70chr5:37605340chr5:33751653ENST00000265107+1018330_369364655.0RepeatNote=WD 4
HgeneWDR70chr5:37605340chr5:33751653ENST00000265107+1018376_415364655.0RepeatNote=WD 5
HgeneWDR70chr5:37605340chr5:33751653ENST00000265107+1018421_466364655.0RepeatNote=WD 6
HgeneWDR70chr5:37605340chr5:33751653ENST00000265107+1018469_508364655.0RepeatNote=WD 7


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Fusion Gene Sequence for WDR70-ADAMTS12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99068_99068_1_WDR70-ADAMTS12_WDR70_chr5_37605340_ENST00000265107_ADAMTS12_chr5_33751653_ENST00000352040_length(transcript)=5296nt_BP=1248nt
CGCGGTCCCTCTGCGGAAGGCGCCGCTCTTGGCTTCGGCGGCGCCGCTGTAGCTTGAAGGCGGTACTTCCTCCAGCATTTGCCGCAAGTT
ATTGGCAAGTTCCCCTGCAGTTGTTTGGGCTGTCCCTGTGGCTGGTTCTGGGGTGTGCGGCCAGCCATGGAGCGCTCTGGGCCCAGCGAA
GTGACAGGCTCAGACGCGTCGGGACCGGACCCGCAGCTTGCGGTCACCATGGGCTTCACGGGGTTCGGTAAAAAAGCTCGCACATTTGAC
TTGGAAGCAATGTTTGAACAAACTCGAAGGACAGCTGTGGAAAGAAGTCGCAAAACACTGGAAGCAAGAGAAAAAGAGGAAGAAATGAAC
AGAGAGAAAGAATTAAGAAGACAAAATGAAGATATTGAGCCAACATCCTCAAGATCAAATGTGGTCAGAGATTGCTCCAAATCATCTTCC
AGGGATACGAGCAGCAGTGAAAGTGAACAGAGTTCTGACTCTTCTGATGATGAGTTAATTGGCCCTCCTTTACCCCCTAAAATGGTAGGA
AAACCAGTTAATTTTATGGAGGAAGATATCCTCGGTCCTTTACCTCCACCTCTTAATGAAGAAGAAGAAGAAGCAGAGGAAGAAGAAGAG
GAAGAGGAGGAAGAGGAAAATCCTGTTCACAAGATTCCTGACTCGCATGAGATAACGCTGAAGCATGGCACTAAAACAGTGTCTGCTTTG
GGTCTGGATCCCTCAGGTGCCCGTTTGGTGACAGGAGGATATGACTATGATGTTAAGTTTTGGGATTTTGCTGGAATGGATGCTTCTTTT
AAGGCATTTCGATCCCTTCAGCCCTGTGAGTGCCATCAGATCAAGTCATTACAGTATAGTAACACAGGAGACATGATTCTTGTTGTATCT
GGAAGCTCTCAGGCCAAGGTGATTGACAGAGATGGTTTTGAAGTAATGGAATGTATAAAAGGAGACCAGTATATTGTGGACATGGCCAAC
ACCAAGGGTCATACAGCAATGCTTCATACTGGCTCATGGCATCCCAAAATAAAGGGAGAATTTATGACTTGCTCAAATGATGCGACTGTG
AGGACGTGGGAAGTTGAAAATCCAAAGAAGCAAAAAAGTGTGTTTAAACCACGGACGATGCAAGGCAAAAAAGTCATTCCCACTACGTGC
ACATATAGTAGAGATGGAAACCTCATAGCAGCTGCCTGCCAGAATGGAAGCATACAGATCTGGGACCGAAATTTGACTACTGGATTTTTC
CAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCATCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGG
CAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGACAGTGTTAACATCTCCCAGAAGCAAGAGCTATGGCGGGAGAAGTGG
GAGAGGCACAACTTGCCAAGCAGAAGCCTCTCTCGGCGTTCCATCAGCAAGGAGAGATGGGTGGAGACACTGGTGGTGGCCGACACAAAG
ATGATTGAATACCATGGGAGTGAGAATGTGGAGTCCTACATCCTCACCATCATGAACATGGTCACTGGGTTGTTCCATAACCCAAGCATT
GGCAATGCAATTCACATTGTTGTGGTTCGGCTCATTCTACTCGAAGAAGAAGAGCAAGGACTGAAAATAGTTCACCATGCAGAAAAGACA
CTGTCTAGCTTCTGCAAGTGGCAGAAGAGTATCAATCCCAAGAGTGACCTCAATCCTGTTCATCACGACGTGGCTGTCCTTCTCACCAGA
AAGGACATCTGTGCTGGTTTCAATCGCCCCTGCGAGACCCTGGGCCTGTCTCACCTTTCAGGAATGTGTCAGCCTCACCGCAGTTGTAAC
ATCAATGAAGATTCGGGACTCCCTCTGGCTTTCACAATTGCCCATGAGCTAGGACACAGCTTCGGCATCCAGCATGATGGGAAAGAAAAT
GACTGTGAGCCTGTGGGCAGACATCCGTACATCATGTCCCGCCAGCTCCAGTACGATCCCACTCCGCTGACATGGTCCAAGTGCAGCGAG
GAGTACATCACCCGCTTCTTGGACCGAGGCTGGGGGTTCTGTCTTGATGACATACCTAAAAAGAAAGGCTTGAAGTCCAAGGTCATTGCC
CCCGGAGTGATCTATGATGTTCACCACCAGTGCCAGCTACAATATGGACCCAATGCTACCTTCTGCCAGGAAGTAGAAAACGTCTGCCAG
ACACTGTGGTGCTCCGTGAAGGGCTTTTGTCGCTCTAAGCTGGACGCTGCTGCAGATGGAACTCAATGTGGTGAGAAGAAGTGGTGTATG
GCAGGCAAGTGCATCACAGTGGGGAAGAAACCAGAGAGCATTCCTGGAGGCTGGGGCCGCTGGTCACCCTGGTCCCACTGTTCCAGGACC
TGTGGGGCTGGAGTCCAGAGCGCAGAGAGGCTCTGCAACAACCCCGAGCCAAAGTTTGGAGGGAAATATTGCACTGGAGAAAGAAAACGC
TATCGCTTGTGCAACGTCCACCCCTGTCGCTCAGAGGCACCAACATTTCGGCAGATGCAGTGCAGTGAATTTGACACTGTTCCCTACAAG
AATGAACTCTACCACTGGTTTCCCATTTTTAACCCAGGTTATGTTGACATTGGGCTCATTCCAAAAGGAGCAAGGGACATAAGAGTGATG
GAAATTGAGGGAGCTGGAAACTTCCTGGCCATCAGGAGTGAAGATCCTGAAAAATATTACCTGAATGGAGGGTTTATTATCCAGTGGAAC
GGGAACTATAAGCTGGCAGGGACTGTCTTTCAGTATGACAGGAAAGGAGACCTGGAAAAGCTGATGGCCACAGGTCCCACCAATGAGTCT
GTGTGGATCCAGCTTCTATTCCAGGTGACTAACCCTGGCATCAAGTATGAGTACACAATCCAGAAAGATGGCCTTGACAATGATGTTGAG
CAGCAGATGTACTTCTGGCAGTACGGCCACTGGACAGAGTGCAGTGTGACCTGCGGGACAGGTATCCGCCGCCAAACTGCCCATTGCATA
AAGAAGGGCCGCGGGATGGTGAAAGCTACATTCTGTGACCCAGAAACACAGCCCAATGGGAGACAGAAGAAGTGCCATGAAAAGGCTTGT
CCACCCAGGTGGTGGGCAGGGGAGTGGGAAGCATGCTCGGCGACATGCGGGCCCCACGGGGAGAAGAAGCGAACCGTGCTGTGCATCCAG
ACCATGGTCTCTGACGAGCAGGCTCTCCCGCCCACAGACTGCCAGCACCTGCTGAAGCCCAAGACCCTCCTTTCCTGCAACAGAGACATC
CTGTGCCCCTCGGACTGGACAGTGGGCAACTGGAGTGAGTGTTCTGTTTCCTGTGGTGGTGGAGTGCGGATTCGCAGTGTCACATGTGCC
AAGAACCATGATGAACCTTGCGATGTGACAAGGAAACCCAACAGCCGAGCTCTGTGTGGCCTCCAGCAATGCCCTTCTAGCCGGAGAGTT
CTGAAACCAAACAAAGGCACTATTTCCAATGGAAAAAACCCACCAACACTAAAGCCCGTCCCTCCACCTACATCCAGGCCCAGAATGCTG
ACCACACCCACAGGGCCTGAGTCTATGAGCACAAGCACTCCAGCAATCAGCAGCCCTAGTCCTACCACAGCCTCCAAAGAAGGAGACCTG
GGTGGGAAACAGTGGCAAGATAGCTCAACCCAACCTGAGCTGAGCTCTCGCTATCTCATTTCCACTGGAAGCACTTCCCAGCCCATCCTC
ACTTCCCAATCCTTGAGCATTCAGCCAAGTGAGGAAAATGTTTCCAGTTCAGATACTGGTCCTACCTCGGAGGGAGGCCTTGTAGCTACA
ACAACAAGTGGTTCTGGCTTGTCATCTTCCCGCAACCCTATCACTTGGCCTGTGACTCCATTTTACAATACCTTGACCAAAGGTCCAGAA
ATGGAGATTCACAGTGGCTCAGGGGAAGAAAGAGAACAGCCTGAGGACAAAGATGAAAGCAATCCTGTAATATGGACCAAGATCAGAGTA
CCTGGAAATGACGCTCCAGTGGAAAGTACAGAAATGCCACTTGCACCTCCACTAACACCAGATCTCAGCAGGGAGTCCTGGTGGCCACCC
TTCAGCACAGTAATGGAAGGACTGCTCCCCAGCCAAAGGCCCACTACTTCCGAAACTGGGACACCCAGAGTTGAGGGGATGGTTACTGAA
AAGCCAGCCAACACTCTGCTCCCTCTGGGAGGAGACCACCAGCCAGAACCCTCAGGAAAGACGGCAAACCGTAACCACCTGAAACTTCCA
AACAACATGAACCAAACAAAAAGTTCTGAACCAGTCCTGACTGAGGAGGATGCAACAAGTCTGATTACTGAGGGCTTTTTGCTAAATGCC
TCCAATTACAAGCAGCTCACAAACGGCCACGGCTCTGCACACTGGATCGTCGGAAACTGGAGCGAGTGCTCCACCACATGTGGCCTGGGG
GCCTACTGGAGAAGGGTGGAGTGCAGCACCCAGATGGATTCTGACTGTGCGGCCATCCAGAGACCTGACCCTGCAAAAAGATGCCACCTC
CGTCCCTGTGCTGGCTGGAAAGTGGGAAACTGGAGCAAGTGCTCCAGAAACTGCAGTGGGGGCTTCAAGATACGCGAGATTCAGTGCGTG
GACAGCCGGGACCACCGGAACCTGAGGCCATTTCACTGCCAGTTCCTGGCCGGCATTCCTCCCCCATTGAGCATGAGCTGTAACCCGGAG
CCCTGTGAGGCGTGGCAGGTGGAGCCTTGGAGCCAGTGCTCCAGGTCCTGTGGAGGTGGAGTTCAGGAGAGAGGAGTGTTCTGTCCAGGA
GGCCTCTGTGATTGGACAAAAAGACCCACATCCACCATGTCTTGCAATGAGCACCTGTGCTGTCACTGGGCCACTGGGAACTGGGACCTG
TGTTCCACTTCCTGTGGAGGTGGCTTTCAGAAGAGGACTGTCCAATGTGTGCCCTCAGAGGGCAATAAAACTGAAGACCAAGACCAATGT
CTATGTGATCACAAACCCAGACCTCCAGAATTCAAAAAATGCAACCAGCAGGCCTGCAAGAAAAGTGCCGATTTACTTTGCACTAAGGAC
AAACTGTCAGCCAGTTTCTGCCAGACACTGAAAGCCATGAAGAAATGTTCTGTGCCCACCGTGAGGGCTGAGTGCTGCTTCTCGTGTCCC

>99068_99068_1_WDR70-ADAMTS12_WDR70_chr5_37605340_ENST00000265107_ADAMTS12_chr5_33751653_ENST00000352040_length(amino acids)=1736AA_BP=388
MPQVIGKFPCSCLGCPCGWFWGVRPAMERSGPSEVTGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREKE
EEMNREKELRRQNEDIEPTSSRSNVVRDCSKSSSRDTSSSESEQSSDSSDDELIGPPLPPKMVGKPVNFMEEDILGPLPPPLNEEEEEAE
EEEEEEEEEENPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMI
LVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVI
PTTCTYSRDGNLIAAACQNGSIQIWDRNLTTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQKQELW
REKWERHNLPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHH
AEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHD
GKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVE
NVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTG
ERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFI
IQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQT
AHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSC
NRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSR
PRMLTTPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGG
LVATTTSGSGLSSSRNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRES
WWPPFSTVMEGLLPSQRPTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGF
LLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIRE
IQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATG
NWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECC

--------------------------------------------------------------
>99068_99068_2_WDR70-ADAMTS12_WDR70_chr5_37605340_ENST00000265107_ADAMTS12_chr5_33751653_ENST00000504830_length(transcript)=9197nt_BP=1248nt
CGCGGTCCCTCTGCGGAAGGCGCCGCTCTTGGCTTCGGCGGCGCCGCTGTAGCTTGAAGGCGGTACTTCCTCCAGCATTTGCCGCAAGTT
ATTGGCAAGTTCCCCTGCAGTTGTTTGGGCTGTCCCTGTGGCTGGTTCTGGGGTGTGCGGCCAGCCATGGAGCGCTCTGGGCCCAGCGAA
GTGACAGGCTCAGACGCGTCGGGACCGGACCCGCAGCTTGCGGTCACCATGGGCTTCACGGGGTTCGGTAAAAAAGCTCGCACATTTGAC
TTGGAAGCAATGTTTGAACAAACTCGAAGGACAGCTGTGGAAAGAAGTCGCAAAACACTGGAAGCAAGAGAAAAAGAGGAAGAAATGAAC
AGAGAGAAAGAATTAAGAAGACAAAATGAAGATATTGAGCCAACATCCTCAAGATCAAATGTGGTCAGAGATTGCTCCAAATCATCTTCC
AGGGATACGAGCAGCAGTGAAAGTGAACAGAGTTCTGACTCTTCTGATGATGAGTTAATTGGCCCTCCTTTACCCCCTAAAATGGTAGGA
AAACCAGTTAATTTTATGGAGGAAGATATCCTCGGTCCTTTACCTCCACCTCTTAATGAAGAAGAAGAAGAAGCAGAGGAAGAAGAAGAG
GAAGAGGAGGAAGAGGAAAATCCTGTTCACAAGATTCCTGACTCGCATGAGATAACGCTGAAGCATGGCACTAAAACAGTGTCTGCTTTG
GGTCTGGATCCCTCAGGTGCCCGTTTGGTGACAGGAGGATATGACTATGATGTTAAGTTTTGGGATTTTGCTGGAATGGATGCTTCTTTT
AAGGCATTTCGATCCCTTCAGCCCTGTGAGTGCCATCAGATCAAGTCATTACAGTATAGTAACACAGGAGACATGATTCTTGTTGTATCT
GGAAGCTCTCAGGCCAAGGTGATTGACAGAGATGGTTTTGAAGTAATGGAATGTATAAAAGGAGACCAGTATATTGTGGACATGGCCAAC
ACCAAGGGTCATACAGCAATGCTTCATACTGGCTCATGGCATCCCAAAATAAAGGGAGAATTTATGACTTGCTCAAATGATGCGACTGTG
AGGACGTGGGAAGTTGAAAATCCAAAGAAGCAAAAAAGTGTGTTTAAACCACGGACGATGCAAGGCAAAAAAGTCATTCCCACTACGTGC
ACATATAGTAGAGATGGAAACCTCATAGCAGCTGCCTGCCAGAATGGAAGCATACAGATCTGGGACCGAAATTTGACTACTGGATTTTTC
CAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCATCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGG
CAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGACAGTGTTAACATCTCCCAGAAGCAAGAGCTATGGCGGGAGAAGTGG
GAGAGGCACAACTTGCCAAGCAGAAGCCTCTCTCGGCGTTCCATCAGCAAGGAGAGATGGGTGGAGACACTGGTGGTGGCCGACACAAAG
ATGATTGAATACCATGGGAGTGAGAATGTGGAGTCCTACATCCTCACCATCATGAACATGGTCACTGGGTTGTTCCATAACCCAAGCATT
GGCAATGCAATTCACATTGTTGTGGTTCGGCTCATTCTACTCGAAGAAGAAGAGCAAGGACTGAAAATAGTTCACCATGCAGAAAAGACA
CTGTCTAGCTTCTGCAAGTGGCAGAAGAGTATCAATCCCAAGAGTGACCTCAATCCTGTTCATCACGACGTGGCTGTCCTTCTCACCAGA
AAGGACATCTGTGCTGGTTTCAATCGCCCCTGCGAGACCCTGGGCCTGTCTCACCTTTCAGGAATGTGTCAGCCTCACCGCAGTTGTAAC
ATCAATGAAGATTCGGGACTCCCTCTGGCTTTCACAATTGCCCATGAGCTAGGACACAGCTTCGGCATCCAGCATGATGGGAAAGAAAAT
GACTGTGAGCCTGTGGGCAGACATCCGTACATCATGTCCCGCCAGCTCCAGTACGATCCCACTCCGCTGACATGGTCCAAGTGCAGCGAG
GAGTACATCACCCGCTTCTTGGACCGAGGCTGGGGGTTCTGTCTTGATGACATACCTAAAAAGAAAGGCTTGAAGTCCAAGGTCATTGCC
CCCGGAGTGATCTATGATGTTCACCACCAGTGCCAGCTACAATATGGACCCAATGCTACCTTCTGCCAGGAAGTAGAAAACGTCTGCCAG
ACACTGTGGTGCTCCGTGAAGGGCTTTTGTCGCTCTAAGCTGGACGCTGCTGCAGATGGAACTCAATGTGGTGAGAAGAAGTGGTGTATG
GCAGGCAAGTGCATCACAGTGGGGAAGAAACCAGAGAGCATTCCTGGAGGCTGGGGCCGCTGGTCACCCTGGTCCCACTGTTCCAGGACC
TGTGGGGCTGGAGTCCAGAGCGCAGAGAGGCTCTGCAACAACCCCGAGCCAAAGTTTGGAGGGAAATATTGCACTGGAGAAAGAAAACGC
TATCGCTTGTGCAACGTCCACCCCTGTCGCTCAGAGGCACCAACATTTCGGCAGATGCAGTGCAGTGAATTTGACACTGTTCCCTACAAG
AATGAACTCTACCACTGGTTTCCCATTTTTAACCCAGCACATCCTTGTGAGCTCTACTGCCGACCCATAGATGGCCAGTTTTCTGAGAAA
ATGCTGGATGCTGTCATTGATGGTACCCCTTGCTTTGAAGGCGGCAACAGCAGAAATGTCTGTATTAATGGCATATGTAAGATGGTTGGC
TGTGACTATGAGATCGATTCCAATGCCACCGAGGATCGCTGCGGTGTGTGCCTGGGAGATGGCTCTTCCTGCCAGACTGTGAGAAAGATG
TTTAAGCAGAAGGAAGGATCTGGTTATGTTGACATTGGGCTCATTCCAAAAGGAGCAAGGGACATAAGAGTGATGGAAATTGAGGGAGCT
GGAAACTTCCTGGCCATCAGGAGTGAAGATCCTGAAAAATATTACCTGAATGGAGGGTTTATTATCCAGTGGAACGGGAACTATAAGCTG
GCAGGGACTGTCTTTCAGTATGACAGGAAAGGAGACCTGGAAAAGCTGATGGCCACAGGTCCCACCAATGAGTCTGTGTGGATCCAGCTT
CTATTCCAGGTGACTAACCCTGGCATCAAGTATGAGTACACAATCCAGAAAGATGGCCTTGACAATGATGTTGAGCAGCAGATGTACTTC
TGGCAGTACGGCCACTGGACAGAGTGCAGTGTGACCTGCGGGACAGGTATCCGCCGCCAAACTGCCCATTGCATAAAGAAGGGCCGCGGG
ATGGTGAAAGCTACATTCTGTGACCCAGAAACACAGCCCAATGGGAGACAGAAGAAGTGCCATGAAAAGGCTTGTCCACCCAGGTGGTGG
GCAGGGGAGTGGGAAGCATGCTCGGCGACATGCGGGCCCCACGGGGAGAAGAAGCGAACCGTGCTGTGCATCCAGACCATGGTCTCTGAC
GAGCAGGCTCTCCCGCCCACAGACTGCCAGCACCTGCTGAAGCCCAAGACCCTCCTTTCCTGCAACAGAGACATCCTGTGCCCCTCGGAC
TGGACAGTGGGCAACTGGAGTGAGTGTTCTGTTTCCTGTGGTGGTGGAGTGCGGATTCGCAGTGTCACATGTGCCAAGAACCATGATGAA
CCTTGCGATGTGACAAGGAAACCCAACAGCCGAGCTCTGTGTGGCCTCCAGCAATGCCCTTCTAGCCGGAGAGTTCTGAAACCAAACAAA
GGCACTATTTCCAATGGAAAAAACCCACCAACACTAAAGCCCGTCCCTCCACCTACATCCAGGCCCAGAATGCTGACCACACCCACAGGG
CCTGAGTCTATGAGCACAAGCACTCCAGCAATCAGCAGCCCTAGTCCTACCACAGCCTCCAAAGAAGGAGACCTGGGTGGGAAACAGTGG
CAAGATAGCTCAACCCAACCTGAGCTGAGCTCTCGCTATCTCATTTCCACTGGAAGCACTTCCCAGCCCATCCTCACTTCCCAATCCTTG
AGCATTCAGCCAAGTGAGGAAAATGTTTCCAGTTCAGATACTGGTCCTACCTCGGAGGGAGGCCTTGTAGCTACAACAACAAGTGGTTCT
GGCTTGTCATCTTCCCGCAACCCTATCACTTGGCCTGTGACTCCATTTTACAATACCTTGACCAAAGGTCCAGAAATGGAGATTCACAGT
GGCTCAGGGGAAGAAAGAGAACAGCCTGAGGACAAAGATGAAAGCAATCCTGTAATATGGACCAAGATCAGAGTACCTGGAAATGACGCT
CCAGTGGAAAGTACAGAAATGCCACTTGCACCTCCACTAACACCAGATCTCAGCAGGGAGTCCTGGTGGCCACCCTTCAGCACAGTAATG
GAAGGACTGCTCCCCAGCCAAAGGCCCACTACTTCCGAAACTGGGACACCCAGAGTTGAGGGGATGGTTACTGAAAAGCCAGCCAACACT
CTGCTCCCTCTGGGAGGAGACCACCAGCCAGAACCCTCAGGAAAGACGGCAAACCGTAACCACCTGAAACTTCCAAACAACATGAACCAA
ACAAAAAGTTCTGAACCAGTCCTGACTGAGGAGGATGCAACAAGTCTGATTACTGAGGGCTTTTTGCTAAATGCCTCCAATTACAAGCAG
CTCACAAACGGCCACGGCTCTGCACACTGGATCGTCGGAAACTGGAGCGAGTGCTCCACCACATGTGGCCTGGGGGCCTACTGGAGAAGG
GTGGAGTGCAGCACCCAGATGGATTCTGACTGTGCGGCCATCCAGAGACCTGACCCTGCAAAAAGATGCCACCTCCGTCCCTGTGCTGGC
TGGAAAGTGGGAAACTGGAGCAAGTGCTCCAGAAACTGCAGTGGGGGCTTCAAGATACGCGAGATTCAGTGCGTGGACAGCCGGGACCAC
CGGAACCTGAGGCCATTTCACTGCCAGTTCCTGGCCGGCATTCCTCCCCCATTGAGCATGAGCTGTAACCCGGAGCCCTGTGAGGCGTGG
CAGGTGGAGCCTTGGAGCCAGTGCTCCAGGTCCTGTGGAGGTGGAGTTCAGGAGAGAGGAGTGTTCTGTCCAGGAGGCCTCTGTGATTGG
ACAAAAAGACCCACATCCACCATGTCTTGCAATGAGCACCTGTGCTGTCACTGGGCCACTGGGAACTGGGACCTGTGTTCCACTTCCTGT
GGAGGTGGCTTTCAGAAGAGGACTGTCCAATGTGTGCCCTCAGAGGGCAATAAAACTGAAGACCAAGACCAATGTCTATGTGATCACAAA
CCCAGACCTCCAGAATTCAAAAAATGCAACCAGCAGGCCTGCAAGAAAAGTGCCGATTTACTTTGCACTAAGGACAAACTGTCAGCCAGT
TTCTGCCAGACACTGAAAGCCATGAAGAAATGTTCTGTGCCCACCGTGAGGGCTGAGTGCTGCTTCTCGTGTCCCCAGACACACATCACA
CACACCCAAAGGCAAAGAAGGCAACGGTTGCTCCAAAAGTCAAAAGAACTCTAAGCCCAAAAGGAAGCCAGCTTCCACCAGACTGCAGCA
GCCTGCTGACCATGACATGCTTTAGCCCTGGGAGCTGCTTCGTTGAGGTTTTGCTTCATATATTTCAGATTCAGCTTTGGGTCATGATGA
AACAAAATCCATTGTGTTCCTCTAGCCACCGAATGTCCCTCACAGGAGGCCTAGGCTGCCGTACTTGCTGCTCCCTGATAGGAAGGTGAA
ATAGCTAGGAGAATCAGGCAGCACCTGGTATCGGCTCCTGGGAAAGGTGCCAGGTTAGACAGATTTGTGAAATACTGTATTTTTGTTCTC
CCTTAAAGATAAAAACAAAGAGACCAGCTATTTCCCTGACTACCTCAAGAGTATCAGGCAACACTTACCCAGGGGACAAATAATCTTCTT
AATTTATCTTGATGAATACCTTTCTTTTTTTTTTCTTGCCTCCCTGCCTGGGGCAGCTGCTATTTAAAATGTCACAGCGGAGCTTTAGGA
ACATTCCTTTAATTCATCCAGGCAGAGGACTGCTTTCTTCACCCCATGTTCAACTAGGGCAGGAAGTGCTGGTTACATCCCTCAGTCTCT
TCCTCCATCCCTGTAGGGCTCCATATCTGGGCTGCTTAGAGTCTCCTGCCAACCTTGGGACACTAGACTAAGAGGAAACAGGCATAAGAA
ACACAGCCTAAGGGGTTTAGGTCACTTACACAGAAAACACTTCTGGTTTGAAGAGCATTTCTATGAAAACTCGTAAAATGCAAATGAGCA
GAAATCAATTTCTTAATATTACAGAAAAGGAACTGTGGGCCTTTATTCTTCCCACTTTCCTGGCAAATACACACTCCTTTGCAGAAGGGA
AAATGTGTCTTCCTGGCTGACTTCCTCCCATCCTCCAGTCCCCACAGGAGGCCTGAGCTCAGGTCCCACCATCGTCTTGCTGCAGGGGCT
GTATATGCAAAGACCACTATGACCAGCTCTAGGGCTGCCACCTGTCCTCACCTCTTCTCAGGTTGGAAAATGGAGGTTCCATATTAAAAT
ATTTCAAAGAACCAGGTAAATTGTACTAAGTACAAGAACATAGTGCAAACTTCTAATCTAGAGAAAAAACATTTCTAAAAAGTAAGGTAA
AGGGGATCTACTCCTCAGTGTACCCAATATGTAGTTAGTCTTAAAGATCTTTTACTTTGGGGAGAACAGGTGAATCAGGGAGTCCAAAGA
AACTGAAATGAAAGTTAGAATGCTTGTTCTGGATGTTCCTACCTCCCACCAGAAGTCAAAGTAGGCTTGGTCTCAAATTCAGAGCAAATT
TCTAGACAAAGTGATTTCTAAGGGAAGGTACTTACATGAACTGAACCCAGAGAAAGAGGGTAAGTGGGTGGGTGGAGGGGCATAAGCTTC
AAATGAAAGAAGATATCAGAACCAATTCTTGACAGGGAGAAAGGCAAGGATGTGGCCTTCATGTGATGGGCAGCATATTTTCTGACTCAT
GCACAGATACACTTAATACTCCTCATGGAACACAATATCCCACGTCTCCCTTTACCTATCCGTTCAGCAGAATGGTGCTATTAAAAAAAT
GGTGCTAATATCTAGATGGTGGCAGAATTAATGTAAACATAGATAGGCATACAAATGGGTAAGTGTATGTGAAACTCTCCATATACATCT
TCTGTTAAACATGTAACGGTGTTGCTGACCAATGCCAGTTTTATTGCTTGGGTACCTTGAATTTAAGATTTAATATTATGTGCTTTTTAT
TTTTTTCCAAGCCATTAACGTGTATTACTCTCATGAATTCCTGTGAAAAATAAAACAGTGGGATTGGGATGAAATTCAAGATAGACCAGA
AACAGGAGGAAAGTACAAATGTTTACCTAAAGCCAGAGAATTTATTTCTAGATGATAATTACATTATTGTATTCTCTGCCTTTAAACATA
AACATTGCTGGCCGATAGCAATCTCTGGTGAATAATGGTTTTCGAGGAGAGGAGACACTTAAATTGTTAGTGACATGAGTGGAGGAGAAT
CTGATATTTACTAATGAGGCAGTTTGCAAAGACTGTCCCTGAAGTGTAGTGTAGTCTTTCAGGGGGATTCATTTAGTAAGCTAGATTGAT
TTAACCTGGTACTGTACTAGCATAGGGTCAAATACGTGTCATCAGAGACCTGGGTATGACCAGGCTTACAAAACTCAGGAACAAACTCAG
ATTCCTACTGACCTCAACCAACTAAACTAGGCCAAATTTCTCCGTGTACAAAATGGACCACGTTATTTACAATCCACGTGGTGGAGAAGA
TGGTAGACATGTGGAGAGAGTTTGGCCAGGTGCTCCATTCTAGGTCTTTTTCCAGTTTCTCAAAGGCAGAACATTGGCTCCTAATTATTT
GCCATGGATATTTGCTTCCTGTTCTGGAGCTATGTTGTAAGACAGCTGTGTGATGTCCATCATTCTTGACTCCAGAATGAAGACAGGGCT
TGCTGTTTTCTGTCCTGTTGGTATCATCTGTTGCCTTGGCGATCACTCAGTGATGAGTCGTCAGTATTTTGACATGTCCCAGTGCTTGCT
GTACAAGAGGGGACTCAGATCAACAGGAAGACTCTGAAGACAGGAACCTGCATGGTATCTTACATCTTTGATACTTGGGTGCTGATATGA
AGCAGAGTTGTTGATTTACTTTATCTAGGCCCTTCTTTCTTCTCACCTGGATCAAGCAACTGAGAAGTGTATCAGGAGACACTGGATACA
TATCTCTATGAAATAGAGAGGGCCATCGCAGGGCCTGGTACTTAACTACATTAACGTTCTAAAACCCAGTTTGGTTTACGTTGTCTTTCA
CAGTAGTATATTTAGCTCTTCTCTGGAAAGTTGTGGGTTAATATAATTCTTAAACATGAAAATGTAATTAAACACACCACGAGAGAACAA
TATTCCAGGAGACTTAATAGTGATTACTTTCTTCAATCAGGAAATCGTTTCAGTGCCTCCTTTGTAGGAATGCTTTGTTTTGTGATGGGT
TTTCTTAAAGAAGAGCACACCTCCGTCCAATCTCCTGAGACAGCCACGTCTCCGCTGACATCCCACTGTGATGCTTTCAGATAGTCAGTG
AATGTTTCTGATAACCTTCATCCAGTATCTGAAACACAATGTGAGAGATTATATTGTTTTAGATAATAACATCCCATTTAGTTGACTAAA
ATCTTCCAAACTCTGAAAGCTGCACACTGCTACTCCAGAGAGTGCAGGTCTTAGCTCTTCTCCTTTCTGACTTCAAGATGAATCTTTGGG
ACGATGTTTCTGGTGCTTGGTCCACAGTGATTCACTTTTGAAGGAGAGGCCACATGACATGAACTGCCTGGTGTTACAACCTAGCTAACA
TATTTGATGCTACTCCTGTTGTCTGTACTGCTTATTCAAGTAGTATTCTAAGTTATGTTACTAAAAAACATGGTGGGTAAAGCACAATCC
TACCCATCATTGTCCTCCAAAATAATTGTATGACATACACGGCCCAGCCCATTGCCCTCCCTGCATCTCTGTGCTGCTTTGCCATTTCCC
CTTCTACCCAGCCTCCTCAAGGGGTACCTTGGTGGATATTTCAGTACTTAAAACCAGACTGTAATCATAACCTCCCTCTGTGTGGCATCA

>99068_99068_2_WDR70-ADAMTS12_WDR70_chr5_37605340_ENST00000265107_ADAMTS12_chr5_33751653_ENST00000504830_length(amino acids)=1821AA_BP=388
MPQVIGKFPCSCLGCPCGWFWGVRPAMERSGPSEVTGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREKE
EEMNREKELRRQNEDIEPTSSRSNVVRDCSKSSSRDTSSSESEQSSDSSDDELIGPPLPPKMVGKPVNFMEEDILGPLPPPLNEEEEEAE
EEEEEEEEEENPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMI
LVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVI
PTTCTYSRDGNLIAAACQNGSIQIWDRNLTTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQKQELW
REKWERHNLPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHH
AEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHD
GKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVE
NVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTG
ERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGIC
KMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNG
NYKLAGTVFQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIK
KGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDIL
CPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLT
TPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGGLVATT
TSGSGLSSSRNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRESWWPPF
STVMEGLLPSQRPTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNAS
NYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVD
SRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLC
STSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQ

--------------------------------------------------------------
>99068_99068_3_WDR70-ADAMTS12_WDR70_chr5_37605340_ENST00000504564_ADAMTS12_chr5_33751653_ENST00000352040_length(transcript)=5223nt_BP=1175nt
AGCATTTGCCGCAAGTTATTGGCAAGTTCCCCTGCAGTTGTTTGGGCTGTCCCTGTGGCTGGTTCTGGGGTGTGCGGCCAGCCATGGAGC
GCTCTGGGCCCAGCGAAGTGACAGGCTCAGACGCGTCGGGACCGGACCCGCAGCTTGCGGTCACCATGGGCTTCACGGGGTTCGGTAAAA
AAGCTCGCACATTTGACTTGGAAGCAATGTTTGAACAAACTCGAAGGACAGCTGTGGAAAGAAGTCGCAAAACACTGGAAGCAAGAGAAA
AAGAGGAAGAAATGAACAGAGAGAAAGAATTAAGAAGACAAAATGAAGATATTGAGCCAACATCCTCAAGATCAAATGTGGTCAGAGATT
GCTCCAAATCATCTTCCAGGGATACGAGCAGCAGTGAAAGTGAACAGAGTTCTGACTCTTCTGATGATGAGTTAATTGGCCCTCCTTTAC
CCCCTAAAATGGTAGGAAAACCAGTTAATTTTATGGAGGAAGATATCCTCGGTCCTTTACCTCCACCTCTTAATGAAGAAGAAGAAGAAG
CAGAGGAAGAAGAAGAGGAAGAGGAGGAAGAGGAAAATCCTGTTCACAAGATTCCTGACTCGCATGAGATAACGCTGAAGCATGGCACTA
AAACAGTGTCTGCTTTGGGTCTGGATCCCTCAGGTGCCCGTTTGGTGACAGGAGGATATGACTATGATGTTAAGTTTTGGGATTTTGCTG
GAATGGATGCTTCTTTTAAGGCATTTCGATCCCTTCAGCCCTGTGAGTGCCATCAGATCAAGTCATTACAGTATAGTAACACAGGAGACA
TGATTCTTGTTGTATCTGGAAGCTCTCAGGCCAAGGTGATTGACAGAGATGGTTTTGAAGTAATGGAATGTATAAAAGGAGACCAGTATA
TTGTGGACATGGCCAACACCAAGGGTCATACAGCAATGCTTCATACTGGCTCATGGCATCCCAAAATAAAGGGAGAATTTATGACTTGCT
CAAATGATGCGACTGTGAGGACGTGGGAAGTTGAAAATCCAAAGAAGCAAAAAAGTGTGTTTAAACCACGGACGATGCAAGGCAAAAAAG
TCATTCCCACTACGTGCACATATAGTAGAGATGGAAACCTCATAGCAGCTGCCTGCCAGAATGGAAGCATACAGATCTGGGACCGAAATT
TGACTACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCATCCACTGGTTGAGGGAGGGTACCACCCGC
ACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGACAGTGTTAACATCTCCCAGAAGCAAGAGC
TATGGCGGGAGAAGTGGGAGAGGCACAACTTGCCAAGCAGAAGCCTCTCTCGGCGTTCCATCAGCAAGGAGAGATGGGTGGAGACACTGG
TGGTGGCCGACACAAAGATGATTGAATACCATGGGAGTGAGAATGTGGAGTCCTACATCCTCACCATCATGAACATGGTCACTGGGTTGT
TCCATAACCCAAGCATTGGCAATGCAATTCACATTGTTGTGGTTCGGCTCATTCTACTCGAAGAAGAAGAGCAAGGACTGAAAATAGTTC
ACCATGCAGAAAAGACACTGTCTAGCTTCTGCAAGTGGCAGAAGAGTATCAATCCCAAGAGTGACCTCAATCCTGTTCATCACGACGTGG
CTGTCCTTCTCACCAGAAAGGACATCTGTGCTGGTTTCAATCGCCCCTGCGAGACCCTGGGCCTGTCTCACCTTTCAGGAATGTGTCAGC
CTCACCGCAGTTGTAACATCAATGAAGATTCGGGACTCCCTCTGGCTTTCACAATTGCCCATGAGCTAGGACACAGCTTCGGCATCCAGC
ATGATGGGAAAGAAAATGACTGTGAGCCTGTGGGCAGACATCCGTACATCATGTCCCGCCAGCTCCAGTACGATCCCACTCCGCTGACAT
GGTCCAAGTGCAGCGAGGAGTACATCACCCGCTTCTTGGACCGAGGCTGGGGGTTCTGTCTTGATGACATACCTAAAAAGAAAGGCTTGA
AGTCCAAGGTCATTGCCCCCGGAGTGATCTATGATGTTCACCACCAGTGCCAGCTACAATATGGACCCAATGCTACCTTCTGCCAGGAAG
TAGAAAACGTCTGCCAGACACTGTGGTGCTCCGTGAAGGGCTTTTGTCGCTCTAAGCTGGACGCTGCTGCAGATGGAACTCAATGTGGTG
AGAAGAAGTGGTGTATGGCAGGCAAGTGCATCACAGTGGGGAAGAAACCAGAGAGCATTCCTGGAGGCTGGGGCCGCTGGTCACCCTGGT
CCCACTGTTCCAGGACCTGTGGGGCTGGAGTCCAGAGCGCAGAGAGGCTCTGCAACAACCCCGAGCCAAAGTTTGGAGGGAAATATTGCA
CTGGAGAAAGAAAACGCTATCGCTTGTGCAACGTCCACCCCTGTCGCTCAGAGGCACCAACATTTCGGCAGATGCAGTGCAGTGAATTTG
ACACTGTTCCCTACAAGAATGAACTCTACCACTGGTTTCCCATTTTTAACCCAGGTTATGTTGACATTGGGCTCATTCCAAAAGGAGCAA
GGGACATAAGAGTGATGGAAATTGAGGGAGCTGGAAACTTCCTGGCCATCAGGAGTGAAGATCCTGAAAAATATTACCTGAATGGAGGGT
TTATTATCCAGTGGAACGGGAACTATAAGCTGGCAGGGACTGTCTTTCAGTATGACAGGAAAGGAGACCTGGAAAAGCTGATGGCCACAG
GTCCCACCAATGAGTCTGTGTGGATCCAGCTTCTATTCCAGGTGACTAACCCTGGCATCAAGTATGAGTACACAATCCAGAAAGATGGCC
TTGACAATGATGTTGAGCAGCAGATGTACTTCTGGCAGTACGGCCACTGGACAGAGTGCAGTGTGACCTGCGGGACAGGTATCCGCCGCC
AAACTGCCCATTGCATAAAGAAGGGCCGCGGGATGGTGAAAGCTACATTCTGTGACCCAGAAACACAGCCCAATGGGAGACAGAAGAAGT
GCCATGAAAAGGCTTGTCCACCCAGGTGGTGGGCAGGGGAGTGGGAAGCATGCTCGGCGACATGCGGGCCCCACGGGGAGAAGAAGCGAA
CCGTGCTGTGCATCCAGACCATGGTCTCTGACGAGCAGGCTCTCCCGCCCACAGACTGCCAGCACCTGCTGAAGCCCAAGACCCTCCTTT
CCTGCAACAGAGACATCCTGTGCCCCTCGGACTGGACAGTGGGCAACTGGAGTGAGTGTTCTGTTTCCTGTGGTGGTGGAGTGCGGATTC
GCAGTGTCACATGTGCCAAGAACCATGATGAACCTTGCGATGTGACAAGGAAACCCAACAGCCGAGCTCTGTGTGGCCTCCAGCAATGCC
CTTCTAGCCGGAGAGTTCTGAAACCAAACAAAGGCACTATTTCCAATGGAAAAAACCCACCAACACTAAAGCCCGTCCCTCCACCTACAT
CCAGGCCCAGAATGCTGACCACACCCACAGGGCCTGAGTCTATGAGCACAAGCACTCCAGCAATCAGCAGCCCTAGTCCTACCACAGCCT
CCAAAGAAGGAGACCTGGGTGGGAAACAGTGGCAAGATAGCTCAACCCAACCTGAGCTGAGCTCTCGCTATCTCATTTCCACTGGAAGCA
CTTCCCAGCCCATCCTCACTTCCCAATCCTTGAGCATTCAGCCAAGTGAGGAAAATGTTTCCAGTTCAGATACTGGTCCTACCTCGGAGG
GAGGCCTTGTAGCTACAACAACAAGTGGTTCTGGCTTGTCATCTTCCCGCAACCCTATCACTTGGCCTGTGACTCCATTTTACAATACCT
TGACCAAAGGTCCAGAAATGGAGATTCACAGTGGCTCAGGGGAAGAAAGAGAACAGCCTGAGGACAAAGATGAAAGCAATCCTGTAATAT
GGACCAAGATCAGAGTACCTGGAAATGACGCTCCAGTGGAAAGTACAGAAATGCCACTTGCACCTCCACTAACACCAGATCTCAGCAGGG
AGTCCTGGTGGCCACCCTTCAGCACAGTAATGGAAGGACTGCTCCCCAGCCAAAGGCCCACTACTTCCGAAACTGGGACACCCAGAGTTG
AGGGGATGGTTACTGAAAAGCCAGCCAACACTCTGCTCCCTCTGGGAGGAGACCACCAGCCAGAACCCTCAGGAAAGACGGCAAACCGTA
ACCACCTGAAACTTCCAAACAACATGAACCAAACAAAAAGTTCTGAACCAGTCCTGACTGAGGAGGATGCAACAAGTCTGATTACTGAGG
GCTTTTTGCTAAATGCCTCCAATTACAAGCAGCTCACAAACGGCCACGGCTCTGCACACTGGATCGTCGGAAACTGGAGCGAGTGCTCCA
CCACATGTGGCCTGGGGGCCTACTGGAGAAGGGTGGAGTGCAGCACCCAGATGGATTCTGACTGTGCGGCCATCCAGAGACCTGACCCTG
CAAAAAGATGCCACCTCCGTCCCTGTGCTGGCTGGAAAGTGGGAAACTGGAGCAAGTGCTCCAGAAACTGCAGTGGGGGCTTCAAGATAC
GCGAGATTCAGTGCGTGGACAGCCGGGACCACCGGAACCTGAGGCCATTTCACTGCCAGTTCCTGGCCGGCATTCCTCCCCCATTGAGCA
TGAGCTGTAACCCGGAGCCCTGTGAGGCGTGGCAGGTGGAGCCTTGGAGCCAGTGCTCCAGGTCCTGTGGAGGTGGAGTTCAGGAGAGAG
GAGTGTTCTGTCCAGGAGGCCTCTGTGATTGGACAAAAAGACCCACATCCACCATGTCTTGCAATGAGCACCTGTGCTGTCACTGGGCCA
CTGGGAACTGGGACCTGTGTTCCACTTCCTGTGGAGGTGGCTTTCAGAAGAGGACTGTCCAATGTGTGCCCTCAGAGGGCAATAAAACTG
AAGACCAAGACCAATGTCTATGTGATCACAAACCCAGACCTCCAGAATTCAAAAAATGCAACCAGCAGGCCTGCAAGAAAAGTGCCGATT
TACTTTGCACTAAGGACAAACTGTCAGCCAGTTTCTGCCAGACACTGAAAGCCATGAAGAAATGTTCTGTGCCCACCGTGAGGGCTGAGT
GCTGCTTCTCGTGTCCCCAGACACACATCACACACACCCAAAGGCAAAGAAGGCAACGGTTGCTCCAAAAGTCAAAAGAACTCTAAGCCC

>99068_99068_3_WDR70-ADAMTS12_WDR70_chr5_37605340_ENST00000504564_ADAMTS12_chr5_33751653_ENST00000352040_length(amino acids)=1736AA_BP=388
MPQVIGKFPCSCLGCPCGWFWGVRPAMERSGPSEVTGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREKE
EEMNREKELRRQNEDIEPTSSRSNVVRDCSKSSSRDTSSSESEQSSDSSDDELIGPPLPPKMVGKPVNFMEEDILGPLPPPLNEEEEEAE
EEEEEEEEEENPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMI
LVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVI
PTTCTYSRDGNLIAAACQNGSIQIWDRNLTTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQKQELW
REKWERHNLPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHH
AEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHD
GKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVE
NVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTG
ERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFI
IQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQT
AHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSC
NRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSR
PRMLTTPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGG
LVATTTSGSGLSSSRNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRES
WWPPFSTVMEGLLPSQRPTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGF
LLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIRE
IQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATG
NWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECC

--------------------------------------------------------------
>99068_99068_4_WDR70-ADAMTS12_WDR70_chr5_37605340_ENST00000504564_ADAMTS12_chr5_33751653_ENST00000504830_length(transcript)=9124nt_BP=1175nt
AGCATTTGCCGCAAGTTATTGGCAAGTTCCCCTGCAGTTGTTTGGGCTGTCCCTGTGGCTGGTTCTGGGGTGTGCGGCCAGCCATGGAGC
GCTCTGGGCCCAGCGAAGTGACAGGCTCAGACGCGTCGGGACCGGACCCGCAGCTTGCGGTCACCATGGGCTTCACGGGGTTCGGTAAAA
AAGCTCGCACATTTGACTTGGAAGCAATGTTTGAACAAACTCGAAGGACAGCTGTGGAAAGAAGTCGCAAAACACTGGAAGCAAGAGAAA
AAGAGGAAGAAATGAACAGAGAGAAAGAATTAAGAAGACAAAATGAAGATATTGAGCCAACATCCTCAAGATCAAATGTGGTCAGAGATT
GCTCCAAATCATCTTCCAGGGATACGAGCAGCAGTGAAAGTGAACAGAGTTCTGACTCTTCTGATGATGAGTTAATTGGCCCTCCTTTAC
CCCCTAAAATGGTAGGAAAACCAGTTAATTTTATGGAGGAAGATATCCTCGGTCCTTTACCTCCACCTCTTAATGAAGAAGAAGAAGAAG
CAGAGGAAGAAGAAGAGGAAGAGGAGGAAGAGGAAAATCCTGTTCACAAGATTCCTGACTCGCATGAGATAACGCTGAAGCATGGCACTA
AAACAGTGTCTGCTTTGGGTCTGGATCCCTCAGGTGCCCGTTTGGTGACAGGAGGATATGACTATGATGTTAAGTTTTGGGATTTTGCTG
GAATGGATGCTTCTTTTAAGGCATTTCGATCCCTTCAGCCCTGTGAGTGCCATCAGATCAAGTCATTACAGTATAGTAACACAGGAGACA
TGATTCTTGTTGTATCTGGAAGCTCTCAGGCCAAGGTGATTGACAGAGATGGTTTTGAAGTAATGGAATGTATAAAAGGAGACCAGTATA
TTGTGGACATGGCCAACACCAAGGGTCATACAGCAATGCTTCATACTGGCTCATGGCATCCCAAAATAAAGGGAGAATTTATGACTTGCT
CAAATGATGCGACTGTGAGGACGTGGGAAGTTGAAAATCCAAAGAAGCAAAAAAGTGTGTTTAAACCACGGACGATGCAAGGCAAAAAAG
TCATTCCCACTACGTGCACATATAGTAGAGATGGAAACCTCATAGCAGCTGCCTGCCAGAATGGAAGCATACAGATCTGGGACCGAAATT
TGACTACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCATCCACTGGTTGAGGGAGGGTACCACCCGC
ACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGACAGTGTTAACATCTCCCAGAAGCAAGAGC
TATGGCGGGAGAAGTGGGAGAGGCACAACTTGCCAAGCAGAAGCCTCTCTCGGCGTTCCATCAGCAAGGAGAGATGGGTGGAGACACTGG
TGGTGGCCGACACAAAGATGATTGAATACCATGGGAGTGAGAATGTGGAGTCCTACATCCTCACCATCATGAACATGGTCACTGGGTTGT
TCCATAACCCAAGCATTGGCAATGCAATTCACATTGTTGTGGTTCGGCTCATTCTACTCGAAGAAGAAGAGCAAGGACTGAAAATAGTTC
ACCATGCAGAAAAGACACTGTCTAGCTTCTGCAAGTGGCAGAAGAGTATCAATCCCAAGAGTGACCTCAATCCTGTTCATCACGACGTGG
CTGTCCTTCTCACCAGAAAGGACATCTGTGCTGGTTTCAATCGCCCCTGCGAGACCCTGGGCCTGTCTCACCTTTCAGGAATGTGTCAGC
CTCACCGCAGTTGTAACATCAATGAAGATTCGGGACTCCCTCTGGCTTTCACAATTGCCCATGAGCTAGGACACAGCTTCGGCATCCAGC
ATGATGGGAAAGAAAATGACTGTGAGCCTGTGGGCAGACATCCGTACATCATGTCCCGCCAGCTCCAGTACGATCCCACTCCGCTGACAT
GGTCCAAGTGCAGCGAGGAGTACATCACCCGCTTCTTGGACCGAGGCTGGGGGTTCTGTCTTGATGACATACCTAAAAAGAAAGGCTTGA
AGTCCAAGGTCATTGCCCCCGGAGTGATCTATGATGTTCACCACCAGTGCCAGCTACAATATGGACCCAATGCTACCTTCTGCCAGGAAG
TAGAAAACGTCTGCCAGACACTGTGGTGCTCCGTGAAGGGCTTTTGTCGCTCTAAGCTGGACGCTGCTGCAGATGGAACTCAATGTGGTG
AGAAGAAGTGGTGTATGGCAGGCAAGTGCATCACAGTGGGGAAGAAACCAGAGAGCATTCCTGGAGGCTGGGGCCGCTGGTCACCCTGGT
CCCACTGTTCCAGGACCTGTGGGGCTGGAGTCCAGAGCGCAGAGAGGCTCTGCAACAACCCCGAGCCAAAGTTTGGAGGGAAATATTGCA
CTGGAGAAAGAAAACGCTATCGCTTGTGCAACGTCCACCCCTGTCGCTCAGAGGCACCAACATTTCGGCAGATGCAGTGCAGTGAATTTG
ACACTGTTCCCTACAAGAATGAACTCTACCACTGGTTTCCCATTTTTAACCCAGCACATCCTTGTGAGCTCTACTGCCGACCCATAGATG
GCCAGTTTTCTGAGAAAATGCTGGATGCTGTCATTGATGGTACCCCTTGCTTTGAAGGCGGCAACAGCAGAAATGTCTGTATTAATGGCA
TATGTAAGATGGTTGGCTGTGACTATGAGATCGATTCCAATGCCACCGAGGATCGCTGCGGTGTGTGCCTGGGAGATGGCTCTTCCTGCC
AGACTGTGAGAAAGATGTTTAAGCAGAAGGAAGGATCTGGTTATGTTGACATTGGGCTCATTCCAAAAGGAGCAAGGGACATAAGAGTGA
TGGAAATTGAGGGAGCTGGAAACTTCCTGGCCATCAGGAGTGAAGATCCTGAAAAATATTACCTGAATGGAGGGTTTATTATCCAGTGGA
ACGGGAACTATAAGCTGGCAGGGACTGTCTTTCAGTATGACAGGAAAGGAGACCTGGAAAAGCTGATGGCCACAGGTCCCACCAATGAGT
CTGTGTGGATCCAGCTTCTATTCCAGGTGACTAACCCTGGCATCAAGTATGAGTACACAATCCAGAAAGATGGCCTTGACAATGATGTTG
AGCAGCAGATGTACTTCTGGCAGTACGGCCACTGGACAGAGTGCAGTGTGACCTGCGGGACAGGTATCCGCCGCCAAACTGCCCATTGCA
TAAAGAAGGGCCGCGGGATGGTGAAAGCTACATTCTGTGACCCAGAAACACAGCCCAATGGGAGACAGAAGAAGTGCCATGAAAAGGCTT
GTCCACCCAGGTGGTGGGCAGGGGAGTGGGAAGCATGCTCGGCGACATGCGGGCCCCACGGGGAGAAGAAGCGAACCGTGCTGTGCATCC
AGACCATGGTCTCTGACGAGCAGGCTCTCCCGCCCACAGACTGCCAGCACCTGCTGAAGCCCAAGACCCTCCTTTCCTGCAACAGAGACA
TCCTGTGCCCCTCGGACTGGACAGTGGGCAACTGGAGTGAGTGTTCTGTTTCCTGTGGTGGTGGAGTGCGGATTCGCAGTGTCACATGTG
CCAAGAACCATGATGAACCTTGCGATGTGACAAGGAAACCCAACAGCCGAGCTCTGTGTGGCCTCCAGCAATGCCCTTCTAGCCGGAGAG
TTCTGAAACCAAACAAAGGCACTATTTCCAATGGAAAAAACCCACCAACACTAAAGCCCGTCCCTCCACCTACATCCAGGCCCAGAATGC
TGACCACACCCACAGGGCCTGAGTCTATGAGCACAAGCACTCCAGCAATCAGCAGCCCTAGTCCTACCACAGCCTCCAAAGAAGGAGACC
TGGGTGGGAAACAGTGGCAAGATAGCTCAACCCAACCTGAGCTGAGCTCTCGCTATCTCATTTCCACTGGAAGCACTTCCCAGCCCATCC
TCACTTCCCAATCCTTGAGCATTCAGCCAAGTGAGGAAAATGTTTCCAGTTCAGATACTGGTCCTACCTCGGAGGGAGGCCTTGTAGCTA
CAACAACAAGTGGTTCTGGCTTGTCATCTTCCCGCAACCCTATCACTTGGCCTGTGACTCCATTTTACAATACCTTGACCAAAGGTCCAG
AAATGGAGATTCACAGTGGCTCAGGGGAAGAAAGAGAACAGCCTGAGGACAAAGATGAAAGCAATCCTGTAATATGGACCAAGATCAGAG
TACCTGGAAATGACGCTCCAGTGGAAAGTACAGAAATGCCACTTGCACCTCCACTAACACCAGATCTCAGCAGGGAGTCCTGGTGGCCAC
CCTTCAGCACAGTAATGGAAGGACTGCTCCCCAGCCAAAGGCCCACTACTTCCGAAACTGGGACACCCAGAGTTGAGGGGATGGTTACTG
AAAAGCCAGCCAACACTCTGCTCCCTCTGGGAGGAGACCACCAGCCAGAACCCTCAGGAAAGACGGCAAACCGTAACCACCTGAAACTTC
CAAACAACATGAACCAAACAAAAAGTTCTGAACCAGTCCTGACTGAGGAGGATGCAACAAGTCTGATTACTGAGGGCTTTTTGCTAAATG
CCTCCAATTACAAGCAGCTCACAAACGGCCACGGCTCTGCACACTGGATCGTCGGAAACTGGAGCGAGTGCTCCACCACATGTGGCCTGG
GGGCCTACTGGAGAAGGGTGGAGTGCAGCACCCAGATGGATTCTGACTGTGCGGCCATCCAGAGACCTGACCCTGCAAAAAGATGCCACC
TCCGTCCCTGTGCTGGCTGGAAAGTGGGAAACTGGAGCAAGTGCTCCAGAAACTGCAGTGGGGGCTTCAAGATACGCGAGATTCAGTGCG
TGGACAGCCGGGACCACCGGAACCTGAGGCCATTTCACTGCCAGTTCCTGGCCGGCATTCCTCCCCCATTGAGCATGAGCTGTAACCCGG
AGCCCTGTGAGGCGTGGCAGGTGGAGCCTTGGAGCCAGTGCTCCAGGTCCTGTGGAGGTGGAGTTCAGGAGAGAGGAGTGTTCTGTCCAG
GAGGCCTCTGTGATTGGACAAAAAGACCCACATCCACCATGTCTTGCAATGAGCACCTGTGCTGTCACTGGGCCACTGGGAACTGGGACC
TGTGTTCCACTTCCTGTGGAGGTGGCTTTCAGAAGAGGACTGTCCAATGTGTGCCCTCAGAGGGCAATAAAACTGAAGACCAAGACCAAT
GTCTATGTGATCACAAACCCAGACCTCCAGAATTCAAAAAATGCAACCAGCAGGCCTGCAAGAAAAGTGCCGATTTACTTTGCACTAAGG
ACAAACTGTCAGCCAGTTTCTGCCAGACACTGAAAGCCATGAAGAAATGTTCTGTGCCCACCGTGAGGGCTGAGTGCTGCTTCTCGTGTC
CCCAGACACACATCACACACACCCAAAGGCAAAGAAGGCAACGGTTGCTCCAAAAGTCAAAAGAACTCTAAGCCCAAAAGGAAGCCAGCT
TCCACCAGACTGCAGCAGCCTGCTGACCATGACATGCTTTAGCCCTGGGAGCTGCTTCGTTGAGGTTTTGCTTCATATATTTCAGATTCA
GCTTTGGGTCATGATGAAACAAAATCCATTGTGTTCCTCTAGCCACCGAATGTCCCTCACAGGAGGCCTAGGCTGCCGTACTTGCTGCTC
CCTGATAGGAAGGTGAAATAGCTAGGAGAATCAGGCAGCACCTGGTATCGGCTCCTGGGAAAGGTGCCAGGTTAGACAGATTTGTGAAAT
ACTGTATTTTTGTTCTCCCTTAAAGATAAAAACAAAGAGACCAGCTATTTCCCTGACTACCTCAAGAGTATCAGGCAACACTTACCCAGG
GGACAAATAATCTTCTTAATTTATCTTGATGAATACCTTTCTTTTTTTTTTCTTGCCTCCCTGCCTGGGGCAGCTGCTATTTAAAATGTC
ACAGCGGAGCTTTAGGAACATTCCTTTAATTCATCCAGGCAGAGGACTGCTTTCTTCACCCCATGTTCAACTAGGGCAGGAAGTGCTGGT
TACATCCCTCAGTCTCTTCCTCCATCCCTGTAGGGCTCCATATCTGGGCTGCTTAGAGTCTCCTGCCAACCTTGGGACACTAGACTAAGA
GGAAACAGGCATAAGAAACACAGCCTAAGGGGTTTAGGTCACTTACACAGAAAACACTTCTGGTTTGAAGAGCATTTCTATGAAAACTCG
TAAAATGCAAATGAGCAGAAATCAATTTCTTAATATTACAGAAAAGGAACTGTGGGCCTTTATTCTTCCCACTTTCCTGGCAAATACACA
CTCCTTTGCAGAAGGGAAAATGTGTCTTCCTGGCTGACTTCCTCCCATCCTCCAGTCCCCACAGGAGGCCTGAGCTCAGGTCCCACCATC
GTCTTGCTGCAGGGGCTGTATATGCAAAGACCACTATGACCAGCTCTAGGGCTGCCACCTGTCCTCACCTCTTCTCAGGTTGGAAAATGG
AGGTTCCATATTAAAATATTTCAAAGAACCAGGTAAATTGTACTAAGTACAAGAACATAGTGCAAACTTCTAATCTAGAGAAAAAACATT
TCTAAAAAGTAAGGTAAAGGGGATCTACTCCTCAGTGTACCCAATATGTAGTTAGTCTTAAAGATCTTTTACTTTGGGGAGAACAGGTGA
ATCAGGGAGTCCAAAGAAACTGAAATGAAAGTTAGAATGCTTGTTCTGGATGTTCCTACCTCCCACCAGAAGTCAAAGTAGGCTTGGTCT
CAAATTCAGAGCAAATTTCTAGACAAAGTGATTTCTAAGGGAAGGTACTTACATGAACTGAACCCAGAGAAAGAGGGTAAGTGGGTGGGT
GGAGGGGCATAAGCTTCAAATGAAAGAAGATATCAGAACCAATTCTTGACAGGGAGAAAGGCAAGGATGTGGCCTTCATGTGATGGGCAG
CATATTTTCTGACTCATGCACAGATACACTTAATACTCCTCATGGAACACAATATCCCACGTCTCCCTTTACCTATCCGTTCAGCAGAAT
GGTGCTATTAAAAAAATGGTGCTAATATCTAGATGGTGGCAGAATTAATGTAAACATAGATAGGCATACAAATGGGTAAGTGTATGTGAA
ACTCTCCATATACATCTTCTGTTAAACATGTAACGGTGTTGCTGACCAATGCCAGTTTTATTGCTTGGGTACCTTGAATTTAAGATTTAA
TATTATGTGCTTTTTATTTTTTTCCAAGCCATTAACGTGTATTACTCTCATGAATTCCTGTGAAAAATAAAACAGTGGGATTGGGATGAA
ATTCAAGATAGACCAGAAACAGGAGGAAAGTACAAATGTTTACCTAAAGCCAGAGAATTTATTTCTAGATGATAATTACATTATTGTATT
CTCTGCCTTTAAACATAAACATTGCTGGCCGATAGCAATCTCTGGTGAATAATGGTTTTCGAGGAGAGGAGACACTTAAATTGTTAGTGA
CATGAGTGGAGGAGAATCTGATATTTACTAATGAGGCAGTTTGCAAAGACTGTCCCTGAAGTGTAGTGTAGTCTTTCAGGGGGATTCATT
TAGTAAGCTAGATTGATTTAACCTGGTACTGTACTAGCATAGGGTCAAATACGTGTCATCAGAGACCTGGGTATGACCAGGCTTACAAAA
CTCAGGAACAAACTCAGATTCCTACTGACCTCAACCAACTAAACTAGGCCAAATTTCTCCGTGTACAAAATGGACCACGTTATTTACAAT
CCACGTGGTGGAGAAGATGGTAGACATGTGGAGAGAGTTTGGCCAGGTGCTCCATTCTAGGTCTTTTTCCAGTTTCTCAAAGGCAGAACA
TTGGCTCCTAATTATTTGCCATGGATATTTGCTTCCTGTTCTGGAGCTATGTTGTAAGACAGCTGTGTGATGTCCATCATTCTTGACTCC
AGAATGAAGACAGGGCTTGCTGTTTTCTGTCCTGTTGGTATCATCTGTTGCCTTGGCGATCACTCAGTGATGAGTCGTCAGTATTTTGAC
ATGTCCCAGTGCTTGCTGTACAAGAGGGGACTCAGATCAACAGGAAGACTCTGAAGACAGGAACCTGCATGGTATCTTACATCTTTGATA
CTTGGGTGCTGATATGAAGCAGAGTTGTTGATTTACTTTATCTAGGCCCTTCTTTCTTCTCACCTGGATCAAGCAACTGAGAAGTGTATC
AGGAGACACTGGATACATATCTCTATGAAATAGAGAGGGCCATCGCAGGGCCTGGTACTTAACTACATTAACGTTCTAAAACCCAGTTTG
GTTTACGTTGTCTTTCACAGTAGTATATTTAGCTCTTCTCTGGAAAGTTGTGGGTTAATATAATTCTTAAACATGAAAATGTAATTAAAC
ACACCACGAGAGAACAATATTCCAGGAGACTTAATAGTGATTACTTTCTTCAATCAGGAAATCGTTTCAGTGCCTCCTTTGTAGGAATGC
TTTGTTTTGTGATGGGTTTTCTTAAAGAAGAGCACACCTCCGTCCAATCTCCTGAGACAGCCACGTCTCCGCTGACATCCCACTGTGATG
CTTTCAGATAGTCAGTGAATGTTTCTGATAACCTTCATCCAGTATCTGAAACACAATGTGAGAGATTATATTGTTTTAGATAATAACATC
CCATTTAGTTGACTAAAATCTTCCAAACTCTGAAAGCTGCACACTGCTACTCCAGAGAGTGCAGGTCTTAGCTCTTCTCCTTTCTGACTT
CAAGATGAATCTTTGGGACGATGTTTCTGGTGCTTGGTCCACAGTGATTCACTTTTGAAGGAGAGGCCACATGACATGAACTGCCTGGTG
TTACAACCTAGCTAACATATTTGATGCTACTCCTGTTGTCTGTACTGCTTATTCAAGTAGTATTCTAAGTTATGTTACTAAAAAACATGG
TGGGTAAAGCACAATCCTACCCATCATTGTCCTCCAAAATAATTGTATGACATACACGGCCCAGCCCATTGCCCTCCCTGCATCTCTGTG
CTGCTTTGCCATTTCCCCTTCTACCCAGCCTCCTCAAGGGGTACCTTGGTGGATATTTCAGTACTTAAAACCAGACTGTAATCATAACCT

>99068_99068_4_WDR70-ADAMTS12_WDR70_chr5_37605340_ENST00000504564_ADAMTS12_chr5_33751653_ENST00000504830_length(amino acids)=1821AA_BP=388
MPQVIGKFPCSCLGCPCGWFWGVRPAMERSGPSEVTGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREKE
EEMNREKELRRQNEDIEPTSSRSNVVRDCSKSSSRDTSSSESEQSSDSSDDELIGPPLPPKMVGKPVNFMEEDILGPLPPPLNEEEEEAE
EEEEEEEEEENPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMI
LVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVI
PTTCTYSRDGNLIAAACQNGSIQIWDRNLTTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQKQELW
REKWERHNLPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHH
AEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHD
GKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVE
NVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTG
ERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGIC
KMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNG
NYKLAGTVFQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIK
KGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDIL
CPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLT
TPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGGLVATT
TSGSGLSSSRNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRESWWPPF
STVMEGLLPSQRPTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNAS
NYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVD
SRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLC
STSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WDR70-ADAMTS12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WDR70-ADAMTS12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WDR70-ADAMTS12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource