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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WDR81-CYB5D1 (FusionGDB2 ID:99111)

Fusion Gene Summary for WDR81-CYB5D1

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR81-CYB5D1
Fusion gene ID: 99111
HgeneTgene
Gene symbol

WDR81

CYB5D1

Gene ID

124997

124637

Gene nameWD repeat domain 81cytochrome b5 domain containing 1
SynonymsCAMRQ2|HYC3|PPP1R166|SORF-2-
Cytomap

17p13.3

17p13.1

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 81protein phosphatase 1, regulatory subunit 166cytochrome b5 domain-containing protein 1
Modification date2020032020200313
UniProtAcc.

Q6P9G0

Ensembl transtripts involved in fusion geneENST00000309182, ENST00000409644, 
ENST00000419248, ENST00000437219, 
ENST00000446363, ENST00000545662, 
ENST00000570446, ENST00000332439, 
ENST00000571846, 
Fusion gene scores* DoF score4 X 3 X 3=361 X 1 X 1=1
# samples 31
** MAII scorelog2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: WDR81 [Title/Abstract] AND CYB5D1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDR81(1631920)-CYB5D1(7761721), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWDR81

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across WDR81 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CYB5D1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-96-A4JK-01AWDR81chr17

1631920

-CYB5D1chr17

7761721

+


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Fusion Gene ORF analysis for WDR81-CYB5D1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000309182ENST00000570446WDR81chr17

1631920

-CYB5D1chr17

7761721

+
5CDS-intronENST00000409644ENST00000570446WDR81chr17

1631920

-CYB5D1chr17

7761721

+
In-frameENST00000309182ENST00000332439WDR81chr17

1631920

-CYB5D1chr17

7761721

+
In-frameENST00000309182ENST00000571846WDR81chr17

1631920

-CYB5D1chr17

7761721

+
In-frameENST00000409644ENST00000332439WDR81chr17

1631920

-CYB5D1chr17

7761721

+
In-frameENST00000409644ENST00000571846WDR81chr17

1631920

-CYB5D1chr17

7761721

+
intron-3CDSENST00000419248ENST00000332439WDR81chr17

1631920

-CYB5D1chr17

7761721

+
intron-3CDSENST00000419248ENST00000571846WDR81chr17

1631920

-CYB5D1chr17

7761721

+
intron-3CDSENST00000437219ENST00000332439WDR81chr17

1631920

-CYB5D1chr17

7761721

+
intron-3CDSENST00000437219ENST00000571846WDR81chr17

1631920

-CYB5D1chr17

7761721

+
intron-3CDSENST00000446363ENST00000332439WDR81chr17

1631920

-CYB5D1chr17

7761721

+
intron-3CDSENST00000446363ENST00000571846WDR81chr17

1631920

-CYB5D1chr17

7761721

+
intron-3CDSENST00000545662ENST00000332439WDR81chr17

1631920

-CYB5D1chr17

7761721

+
intron-3CDSENST00000545662ENST00000571846WDR81chr17

1631920

-CYB5D1chr17

7761721

+
intron-intronENST00000419248ENST00000570446WDR81chr17

1631920

-CYB5D1chr17

7761721

+
intron-intronENST00000437219ENST00000570446WDR81chr17

1631920

-CYB5D1chr17

7761721

+
intron-intronENST00000446363ENST00000570446WDR81chr17

1631920

-CYB5D1chr17

7761721

+
intron-intronENST00000545662ENST00000570446WDR81chr17

1631920

-CYB5D1chr17

7761721

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000309182WDR81chr171631920-ENST00000571846CYB5D1chr177761721+20567351011048315
ENST00000309182WDR81chr171631920-ENST00000332439CYB5D1chr177761721+39327351011261386
ENST00000409644WDR81chr171631920-ENST00000571846CYB5D1chr177761721+49883667039801326
ENST00000409644WDR81chr171631920-ENST00000332439CYB5D1chr177761721+68643667041931397

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000309182ENST00000571846WDR81chr171631920-CYB5D1chr177761721+0.0045913910.9954086
ENST00000309182ENST00000332439WDR81chr171631920-CYB5D1chr177761721+0.0012239750.998776
ENST00000409644ENST00000571846WDR81chr171631920-CYB5D1chr177761721+0.0020393390.9979607
ENST00000409644ENST00000332439WDR81chr171631920-CYB5D1chr177761721+0.0006276270.9993724

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Fusion Genomic Features for WDR81-CYB5D1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WDR81-CYB5D1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:1631920/chr17:7761721)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CYB5D1

Q6P9G0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR81chr17:1631920chr17:7761721ENST00000409644-1101150_121712221942.0Compositional biasNote=Glu-rich
HgeneWDR81chr17:1631920chr17:7761721ENST00000409644-110337_61412221942.0DomainBEACH
TgeneCYB5D1chr17:1631920chr17:7761721ENST0000033243904199_20253229.0Compositional biasNote=Poly-Glu
TgeneCYB5D1chr17:1631920chr17:7761721ENST0000057184604199_20253158.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR81chr17:1631920chr17:7761721ENST00000309182-2111150_1217171891.0Compositional biasNote=Glu-rich
HgeneWDR81chr17:1631920chr17:7761721ENST00000309182-2111587_1596171891.0Compositional biasNote=Poly-Gly
HgeneWDR81chr17:1631920chr17:7761721ENST00000409644-1101587_159612221942.0Compositional biasNote=Poly-Gly
HgeneWDR81chr17:1631920chr17:7761721ENST00000419248-1101150_12170715.0Compositional biasNote=Glu-rich
HgeneWDR81chr17:1631920chr17:7761721ENST00000419248-1101587_15960715.0Compositional biasNote=Poly-Gly
HgeneWDR81chr17:1631920chr17:7761721ENST00000437219-1101150_12170739.0Compositional biasNote=Glu-rich
HgeneWDR81chr17:1631920chr17:7761721ENST00000437219-1101587_15960739.0Compositional biasNote=Poly-Gly
HgeneWDR81chr17:1631920chr17:7761721ENST00000309182-211337_614171891.0DomainBEACH
HgeneWDR81chr17:1631920chr17:7761721ENST00000419248-110337_6140715.0DomainBEACH
HgeneWDR81chr17:1631920chr17:7761721ENST00000437219-110337_6140739.0DomainBEACH
HgeneWDR81chr17:1631920chr17:7761721ENST00000309182-2111639_1677171891.0RepeatNote=WD 1
HgeneWDR81chr17:1631920chr17:7761721ENST00000309182-2111686_1724171891.0RepeatNote=WD 2
HgeneWDR81chr17:1631920chr17:7761721ENST00000309182-2111729_1769171891.0RepeatNote=WD 3
HgeneWDR81chr17:1631920chr17:7761721ENST00000309182-2111777_1815171891.0RepeatNote=WD 4
HgeneWDR81chr17:1631920chr17:7761721ENST00000309182-2111819_1856171891.0RepeatNote=WD 5
HgeneWDR81chr17:1631920chr17:7761721ENST00000309182-2111860_1896171891.0RepeatNote=WD 6
HgeneWDR81chr17:1631920chr17:7761721ENST00000309182-2111902_1941171891.0RepeatNote=WD 7
HgeneWDR81chr17:1631920chr17:7761721ENST00000409644-1101639_167712221942.0RepeatNote=WD 1
HgeneWDR81chr17:1631920chr17:7761721ENST00000409644-1101686_172412221942.0RepeatNote=WD 2
HgeneWDR81chr17:1631920chr17:7761721ENST00000409644-1101729_176912221942.0RepeatNote=WD 3
HgeneWDR81chr17:1631920chr17:7761721ENST00000409644-1101777_181512221942.0RepeatNote=WD 4
HgeneWDR81chr17:1631920chr17:7761721ENST00000409644-1101819_185612221942.0RepeatNote=WD 5
HgeneWDR81chr17:1631920chr17:7761721ENST00000409644-1101860_189612221942.0RepeatNote=WD 6
HgeneWDR81chr17:1631920chr17:7761721ENST00000409644-1101902_194112221942.0RepeatNote=WD 7
HgeneWDR81chr17:1631920chr17:7761721ENST00000419248-1101639_16770715.0RepeatNote=WD 1
HgeneWDR81chr17:1631920chr17:7761721ENST00000419248-1101686_17240715.0RepeatNote=WD 2
HgeneWDR81chr17:1631920chr17:7761721ENST00000419248-1101729_17690715.0RepeatNote=WD 3
HgeneWDR81chr17:1631920chr17:7761721ENST00000419248-1101777_18150715.0RepeatNote=WD 4
HgeneWDR81chr17:1631920chr17:7761721ENST00000419248-1101819_18560715.0RepeatNote=WD 5
HgeneWDR81chr17:1631920chr17:7761721ENST00000419248-1101860_18960715.0RepeatNote=WD 6
HgeneWDR81chr17:1631920chr17:7761721ENST00000419248-1101902_19410715.0RepeatNote=WD 7
HgeneWDR81chr17:1631920chr17:7761721ENST00000437219-1101639_16770739.0RepeatNote=WD 1
HgeneWDR81chr17:1631920chr17:7761721ENST00000437219-1101686_17240739.0RepeatNote=WD 2
HgeneWDR81chr17:1631920chr17:7761721ENST00000437219-1101729_17690739.0RepeatNote=WD 3
HgeneWDR81chr17:1631920chr17:7761721ENST00000437219-1101777_18150739.0RepeatNote=WD 4
HgeneWDR81chr17:1631920chr17:7761721ENST00000437219-1101819_18560739.0RepeatNote=WD 5
HgeneWDR81chr17:1631920chr17:7761721ENST00000437219-1101860_18960739.0RepeatNote=WD 6
HgeneWDR81chr17:1631920chr17:7761721ENST00000437219-1101902_19410739.0RepeatNote=WD 7
TgeneCYB5D1chr17:1631920chr17:7761721ENST000003324390417_10053229.0DomainCytochrome b5 heme-binding
TgeneCYB5D1chr17:1631920chr17:7761721ENST000005718460417_10053158.0DomainCytochrome b5 heme-binding


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Fusion Gene Sequence for WDR81-CYB5D1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99111_99111_1_WDR81-CYB5D1_WDR81_chr17_1631920_ENST00000309182_CYB5D1_chr17_7761721_ENST00000332439_length(transcript)=3932nt_BP=735nt
AAAGAGCAGGCGAAAGCCACGGCGTCTGCGTTTGCAATGCATGCTGGTCCGTGTAGTTCTCAGCCTGACACCGTCGTTCCCAGAACCCAG
CGCGCTCTGTGCTGGCGGGCGCAGAGGCCTCCCAGGAGGAGAGCAAGGACCTGGCAGGGGCTGCTGAGGAGGAGGAGAGCGGGCTGCCCG
GGGCCGGGCCTGGCTCCTGTGCTTTTGGGGAGGAGATTCCCATGGATGGGGAGCCTCCTGCCTCCTCGGGCCTGGGGCTCCCAGACTACA
CGTCTGGCGTCAGCTTCCACGACCAGGCTGACCTCCCTGAGACAGAGGACTTCCAAGCCGGGCTCTATGTGACTGAGTCTCCCCAGCCCC
AGGAGGCTGAGGCTGTGAGCCTGGGCCGGCTGAGTGACAAGAGCAGCACCAGCGAGACCTCCCTGGGTGAGGAGCGGGCTCCAGACGAGG
GGGGTGCCCCCGTGGACAAGAGCAGCCTTCGATCAGGTGACAGCAGCCAGGACTTGAAGCAAAGCGAGGGCTCCGAGGAGGAAGAGGAGG
AGGAGGACAGCTGCGTGGTGCTAGAGGAGGAGGAGGGGGAGCAGGAGGAGGTCACCGGGGCATCTGAGCTCACTCTGTCTGACACGGTGC
TGTCCATGGAGACGGTTGTGGCCGGCGGCAGTGGGGGAGATGGAGAAGAAGAGGAGGAGGCACTGCCTGAGCAGTCAGAAGGCAAAGAAC
AGAAGATCCTCCTTGGGAACCTGCTGCTGAAACCCATCGTGGAAGTTGCAGGCCAGGATATCAGCCACTGGTTTGATCCAAAGACCAGAG
ACATCCGCAAGCACATAGATCCGCTGACCGGCTGCCTGAGGTACTGCACCCCGCGGGGCCGCTTTGTGCACGTTCCGCCTCAGCTGCCCT
GTTCGGACTGGGCCAACGATTTTGGGAAGCCCTGGTGGCAGGGGTCGTATTATGAGGTGGGGCGGCTGTCTGCCAAGACCCGGAGCATCC
GCATCATTAACACGCTCACGTCGCAGGAGCACACACTGGAGGTGGGGGTTCTGGAGTCCATATGGGAAATCCTACACCGCTATCTCCCCT
ATAACTCACATGCTGCCAGCTACACGTGGAAATATGAAGGGAAGAACCTGAACATGGATTTTACCCTGGAAGAGAATGGGATCCGGGATG
AGGAGGAAGAATTTGACTATCTCAGTATGGACGGTACACTTCACACACCTGCAATACTTCTGTACTTCAATGATGATCTCACGGAGTTGT
AGGCAAGGAGATGTACACTCGTGTAGACTCAAGACGTATTTCGAGTTTGGCTTTTTCTGTGCCTTGAGGAAAAGTGGTGGGGCCGAGGGG
TGCCTGGACCCAGATCTCCACTCCTCTCCAGGAGCTAGCCTGTGCCCTTCTGAAGTGTAAAGGCCCTATTCCCTGCCTTCATTACAGTTT
GCTCTGAGAAAATTAGTGAATTAATCTTTGGGAATGATACAAGAAGATCAAGTACCTTGGTTTAGGGAGATGTAGAAGAGGATAGTCAGA
GTTCAGGCAGAACTGTTTGATAGTTAAGAGAGAGTAGTTCTACAGGGGTGAGGGATGGAAGGACTTTTTTGGCAATGATGGAAATGAGAT
GTCTGCAGGAAGATGGGATTTACAAAGAAATAGGAAATGTTTATCATTGACCATACAAAGCTGGCTTATCTTACTTGTAGAAGAGTGTTT
GGCAGCTGAAACCCAAGGGAAAGAAAGGAAGTGCGTCATTATAGGCAATTCAGGCTAGATATTATACTAGGTACTTCATATACCCTCTTT
TTTTTTTTTGCCCCCAACAAAGAGAAGGGGTCTTGCTCTGTCACCCAGTCTGGAGTGCAGTGGCAAAATCATGGCTCACTGCAGCCTGGA
GCTCCTGGGCACAAGTGATCCTCCCATCTCTGCCTTGAGTAGCTGGGACTTCAGGTGCACGCCACAATGCCTAATTTTTTAATTTTTTGT
AGACACAGGGTCTCGCTGTGTTGCCCAGGCTGGTTTCAACCTCCTGGCCTCAAGTGATCCTCTTGCCTCAGCCTCCCAAATAGCCTCTTC
AAGACAACTACCCCATAAGGTGGATTACCATTACTATGTTACAGATAAGTCCTTCGAAACTTTGGAAAGTTTAATAGCTCAAAGCCACAC
TAGGTAGTAACCACTAGAGCCAGAATGCAAATTCAAGTCTGCCCAACTCCAAAGTCCATGTTCTCTCAATATAAAGGGACCATCTCAATG
TCTAATCTCATGTTAACATTTGTAGCCACTGCTCTCAGCAAGTATTTGGGATGTGGCTTTGTCCTAGGATCCCTGCACAATAGGAAATTG
TGGTCCTATTGTATAGTTTGCAGTTATTGTCTCTGGAAGGGAGTTTGCAGAGTTCTCCTGTGGCGAAGAGGAGGCAAGGAAGGCTAAGTG
TCAGTTAAGCAATAGCTATTGGGGCTACTTCTTTGTTAATCCCATACCCCAGATTTCTCTCCTGACCTTTTGGGGCAAAGAGGTGGGTAT
TTACTAACTTGAAGGAAAACTAGAGTGGGGAAAAGGCCGGCAAATTAGTGACACTTTGGCGAGGGAGAAAAAGGAGGCAGTTTGCCACTT
GGAGAAGATGAGGAAGACAGGGTTGCAAGACGGTGACTCCAAAAGAGGGAGCTCGACAGGGGTAATGTAAACAGAGATGCTAACTAAGTC
AGAAAACTCTCCTGGTGACCAAAAGAGAACCACTATTGGGGGTAATGGCTAGATTTGGTCTCCTTTAACTTAAGGAGGGGAGATTTGAGA
ATGACAGACAGTTGAACTTCCTGGCAGCAGCAAGCAAAAAACAAATCAGGAAGAGTTTAGTGTGTCTTCTGGCAGGGGACACCAGGGCCC
AGCACAGGAGAAGGTGGCCCCTGTGAGATACTGGTGGGCTATATAGGCATTTTCTGAGGGGCTTTGGGAGGCATGAACAAAGGTGGAAAC
ATTGCTGTTGGCTTCGGCAGTATCTGAATTTACTGTGAGATGGAGGGTTTAAATCTAACCCCATGGAATGCAGGAGTCCATGAATTATCT
AAATCGATCATTTTGATCTTTAATCAACTCTGCAATTATGTGTACCTTGTTTGCTCAATTAAACCCTGAACTATTTGAGAATGAAAGCTA
TGCTGTTCCTCTAGTGCAAGCCTCAGGGCCTGTCCTGTGCCTACAGGATGTCCCCATTCTGCCAAAACCTGTCCCTCTTCCAGAGACTCC
TACTTCAATGTCTCTTGCTAGAAACACATCCCTTTCCTCACACATCCAGTCACTCATCAAGTGTAATCTGTCTCCTAAATATCTCTGGAA
CCTATCTTCTTTTCTCCAAGTTACCATCACCTCTTGTCTAAACTGCTACGGAAACTTCCTAACCTGTTCTCCCATTTCCACTTCTGACTT
CCATGCTGCAATGAGAGTCAGCTATGAAAAACAAACCTAAACATCGAACTTTCCTTAGCTTCTTCAGTGGCTTCCAACTGCTTTTGGAAT
AAAGTCCTAAATTCAAAGATCTTGTATAAATCAGGCTCATCTCGCAACACCCCTCTTTGTTCTCTATGGCCTAGACACACTGGCTTTCAG
TTCATTACATGTCTTGCCTCAGACCCTCACACACTGTCCTCTCTGCCTGCAACACTCTTCCTTTCACTTTCCACCTAGCTGATCCTAAAT
GTTCCTTCCTCAGGGAGGTCTTTTCTGATTTCTTGGTGGGTCAAGACTTTCTGATAAATCAGTTAGCACCATGCATTTTCCAGAGTTTTT
ATTACAATTGTAAAATTATGGCTGTAATAGGCTGGCTGCGCTGCTAGATTGTAAGCTCACGAGGGCAGAGATCTTGTTCACATCTTGCTC

>99111_99111_1_WDR81-CYB5D1_WDR81_chr17_1631920_ENST00000309182_CYB5D1_chr17_7761721_ENST00000332439_length(amino acids)=386AA_BP=183
MAGAEASQEESKDLAGAAEEEESGLPGAGPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFHDQADLPETEDFQAGLYVTESPQPQEAE
AVSLGRLSDKSSTSETSLGEERAPDEGGAPVDKSSLRSGDSSQDLKQSEGSEEEEEEEDSCVVLEEEEGEQEEVTGASELTLSDTVLSME
TVVAGGSGGDGEEEEEALPEQSEGKEQKILLGNLLLKPIVEVAGQDISHWFDPKTRDIRKHIDPLTGCLRYCTPRGRFVHVPPQLPCSDW
ANDFGKPWWQGSYYEVGRLSAKTRSIRIINTLTSQEHTLEVGVLESIWEILHRYLPYNSHAASYTWKYEGKNLNMDFTLEENGIRDEEEE

--------------------------------------------------------------
>99111_99111_2_WDR81-CYB5D1_WDR81_chr17_1631920_ENST00000309182_CYB5D1_chr17_7761721_ENST00000571846_length(transcript)=2056nt_BP=735nt
AAAGAGCAGGCGAAAGCCACGGCGTCTGCGTTTGCAATGCATGCTGGTCCGTGTAGTTCTCAGCCTGACACCGTCGTTCCCAGAACCCAG
CGCGCTCTGTGCTGGCGGGCGCAGAGGCCTCCCAGGAGGAGAGCAAGGACCTGGCAGGGGCTGCTGAGGAGGAGGAGAGCGGGCTGCCCG
GGGCCGGGCCTGGCTCCTGTGCTTTTGGGGAGGAGATTCCCATGGATGGGGAGCCTCCTGCCTCCTCGGGCCTGGGGCTCCCAGACTACA
CGTCTGGCGTCAGCTTCCACGACCAGGCTGACCTCCCTGAGACAGAGGACTTCCAAGCCGGGCTCTATGTGACTGAGTCTCCCCAGCCCC
AGGAGGCTGAGGCTGTGAGCCTGGGCCGGCTGAGTGACAAGAGCAGCACCAGCGAGACCTCCCTGGGTGAGGAGCGGGCTCCAGACGAGG
GGGGTGCCCCCGTGGACAAGAGCAGCCTTCGATCAGGTGACAGCAGCCAGGACTTGAAGCAAAGCGAGGGCTCCGAGGAGGAAGAGGAGG
AGGAGGACAGCTGCGTGGTGCTAGAGGAGGAGGAGGGGGAGCAGGAGGAGGTCACCGGGGCATCTGAGCTCACTCTGTCTGACACGGTGC
TGTCCATGGAGACGGTTGTGGCCGGCGGCAGTGGGGGAGATGGAGAAGAAGAGGAGGAGGCACTGCCTGAGCAGTCAGAAGGCAAAGAAC
AGAAGATCCTCCTTGGGAACCTGCTGCTGAAACCCATCGTGGAAGTTGCAGGCCAGGATATCAGCCACTGGTTTGATCCAAAGACCAGAG
ACATCCGCAAGCACATAGATCCGCTGACCGGCTGCCTGAGGTACTGCACCCCGCGGGGCCGCTTTGTGCACGTTCCGCCTCAGCTGCCCT
GTTCGGACTGGGCCAACGATTTTGGGAAGCCCTGGTGGCAGGGGTCGTATTATGAGGTGGGGCGGCTGTCTGCCAAGACCCGGAGCATCC
GCATCATTAACACGCTCACGTCGCAGGAGCACACACTGGAGCTACACGTGGAAATATGAAGGGAAGAACCTGAACATGGATTTTACCCTG
GAAGAGAATGGGATCCGGGATGAGGAGGAAGAATTTGACTATCTCAGTATGGACGGTACACTTCACACACCTGCAATACTTCTGTACTTC
AATGATGATCTCACGGAGTTGTAGGCAAGGAGATGTACACTCGTGTAGACTCAAGACGTATTTCGAGTTTGGCTTTTTCTGTGCCTTGAG
GAAAAGTGGTGGGGCCGAGGGGTGCCTGGACCCAGATCTCCACTCCTCTCCAGGAGCTAGCCTGTGCCCTTCTGAAGTGTAAAGGCCCTA
TTCCCTGCCTTCATTACAGTTTGCTCTGAGAAAATTAGTGAATTAATCTTTGGGAATGATACAAGAAGATCAAGTACCTTGGTTTAGGGA
GATGTAGAAGAGGATAGTCAGAGTTCAGGCAGAACTGTTTGATAGTTAAGAGAGAGTAGTTCTACAGGGGTGAGGGATGGAAGGACTTTT
TTGGCAATGATGGAAATGAGATGTCTGCAGGAAGATGGGATTTACAAAGAAATAGGAAATGTTTATCATTGACCATACAAAGCTGGCTTA
TCTTACTTGTAGAAGAGTGTTTGGCAGCTGAAACCCAAGGGAAAGAAAGGAAGTGCGTCATTATAGGCAATTCAGGCTAGATATTATACT
AGGTACTTCATATACCCTCTTTTTTTTTTTTGCCCCCAACAAAGAGAAGGGGTCTTGCTCTGTCACCCAGTCTGGAGTGCAGTGGCAAAA
TCATGGCTCACTGCAGCCTGGAGCTCCTGGGCACAAGTGATCCTCCCATCTCTGCCTTGAGTAGCTGGGACTTCAGGTGCACGCCACAAT
GCCTAATTTTTTAATTTTTTGTAGACACAGGGTCTCGCTGTGTTGCCCAGGCTGGTTTCAACCTCCTGGCCTCAAGTGATCCTCTTGCCT

>99111_99111_2_WDR81-CYB5D1_WDR81_chr17_1631920_ENST00000309182_CYB5D1_chr17_7761721_ENST00000571846_length(amino acids)=315AA_BP=183
MAGAEASQEESKDLAGAAEEEESGLPGAGPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFHDQADLPETEDFQAGLYVTESPQPQEAE
AVSLGRLSDKSSTSETSLGEERAPDEGGAPVDKSSLRSGDSSQDLKQSEGSEEEEEEEDSCVVLEEEEGEQEEVTGASELTLSDTVLSME
TVVAGGSGGDGEEEEEALPEQSEGKEQKILLGNLLLKPIVEVAGQDISHWFDPKTRDIRKHIDPLTGCLRYCTPRGRFVHVPPQLPCSDW

--------------------------------------------------------------
>99111_99111_3_WDR81-CYB5D1_WDR81_chr17_1631920_ENST00000409644_CYB5D1_chr17_7761721_ENST00000332439_length(transcript)=6864nt_BP=3667nt
ATGGCCCAGGGCAGCGGGGGGCGGGAAGGCGCTCTCAGAACCCCGGCCGGGGGCTGGCATTCCCCGCCAAGCCCAGACATGCAGGAGCTG
CTCCGGAGCGTGGAGAGGGACCTGAGCATCGATCCCAGGCAGCTGGCTCCGGCCCCGGGGGGCACCCACGTGGTGGCCCTAGTGCCTGCG
CGCTGGCTGGCCAGCCTCCGCGATCGCCGGCTGCCCCTGGGACCCTGTCCCCGCGCAGAGGGCCTGGGAGAAGCGGAAGTCAGGACTCTC
CTGCAGCGCTCTGTGCAAAGGCTGCCTGCCGGCTGGACGCGCGTGGAGGTGCATGGGCTGCGGAAGCGGAGACTGTCCTACCCTCTGGGC
GGGGGCCTGCCCTTTGAGGACGGGTCCTGCGGCCCTGAGACCCTCACTCGCTTCATGCAGGAGGTTGCCGCCCAGAATTATCGCAACCTG
TGGCGCCATGCATACCACACTTACGGCCAGCCGTACAGTCACAGCCCTGCCCCCTCAGCTGTCCCTGCCTTGGACTCAGTACGGCAGGCT
CTGCAGAGGGTCTATGGTTGCTCCTTCCTGCCAGTGGGTGAAACTACCCAATGCCCTTCATATGCCAGAGAAGGCCCCTGCCCCCCTCGG
GGCAGCCCTGCTTGCCCTAGTCTTTTACGGGCTGAGGCCTTGCTGGAGTCGCCGGAGATGCTGTATGTGGTACACCCTTACGTACAGTTC
TCCCTACATGACGTGGTCACCTTCAGCCCTGCCAAGCTGACCAACAGCCAGGCCAAGGTGCTGTTCATTCTCTTCCGCGTGCTGAGGGCT
ATGGACGCCTGTCACCGCCAGGGGCTGGCGTGTGGGGCCCTGTCTTTGTATCACATCGCAGTGGATGAGAAGCTTTGCAGCGAGCTGCGA
CTGGACCTGAGTGCTTATGAGAGGCCCGAGGAGGACGAGAATGAGGAGGCCCCTGTGGCAAGGGATGAGGCGGGCATTGTGTCTCAAGAG
GAGCAGGGAGGGCAACCTGGGCAACCCACTGGCCAGGAGGAACTTCGGAGCCTCGTGCTAGATTGGGTCCACGGCCGCATCAGCAACTTC
CACTACCTCATGCAGCTGAATCGGTTGGCAGGTCGGCGGCAGGGGGACCCCAACTACCACCCCGTGCTGCCCTGGGTGGTGGACTTCACT
ACGCCCCATGGGCGCTTCCGAGACCTGCGCAAGTCCAAGTTCCGCCTCAACAAGGGGGATAAGCAACTGGACTTCACGTATGAGATGACA
CGGCAGGCATTCGTAGCAGGCGGGGCGGGCGGCGGGGAACCCCCTCATGTTCCCCACCACATCTCAGACGTGCTCTCCGACATCACGTAC
TATGTGTACAAGGCTCGGCGCACGCCTCGGTCGGTGCTCTGCGGACACGTCCGCGCGCAGTGGGAGCCCCATGAGTATCCGGCCAGCATG
GAGCGGATGCAGAACTGGACCCCGGATGAGTGCATTCCGGAGTTCTACACCGATCCCTCTATCTTCCGCTCCATCCACCCCGACATGCCT
GACCTGGATGTGCCAGCCTGGTGCAGCTCCAGCCAGGAGTTCGTAGCTGCCCACCGAGCCCTGCTGGAGAGCCGCGAGGTATCCCGGGAC
CTGCACCATTGGATCGACCTCACGTTTGGCTATAAACTCCAGGGTAAGGAGGCTGTCAAGGAAAAGAATGTGTGTCTGCACCTGGTGGAC
GCCCACACTCACCTGGCCAGCTACGGGGTGGTGCAGCTCTTCGATCAGCCACACCCCCAGCGCCTGGCTGGGGCTCCTGCCCTTGCCCCC
GAGCCTCCCCTCATCCCCAAGCTGTTGGTCCAGACCATCCAGGAGACCACAGGCCGGGAGGACTTCACGGAAAACCCGGGACAGCTTCCA
AATGGAGTGGGCCGGCCAGTTTTAGAGGCCACTCCCTGTGAGGCTAGCTGGACCAGAGACAGGCCGGTGGCAGGAGAAGACGACTTGGAA
CAGGCCACAGAAGCTCTGGATTCCATTTCCCTTGCTGGGAAAGCAGGTGACCAGCTGGGCTCCTCCAGTCAAGCGTCCCCTGGACTTCTC
TCTTTCTCAGTGGCCTCAGCCTCCCGTCCAGGCCGCAGGAATAAAGCTGCTGGGGCAGACCCTGGGGAGGGTGAGGAGGGGAGGATTCTT
CTTCCCGAGGGCTTCAATCCCATGCAGGCCCTGGAGGAGCTGGAGAAAACGGGCAACTTCTTGGCCAAAGGCCTAGGGGGCCTGTTGGAG
GTGCCTGAGCAGCCCCGGGTCCAGCCGGCTGTGCCACTGCAGTGCCTACTCCACAGGGACATGCAGGCGCTGGGTGTCCTATTGGCAGAG
ATGGTGTTTGCCACCAGGGTGCGGACGCTGCAGCCCGATGCACCTTTGTGGGTACGCTTCCAGGCTGTCCGAGGGCTCTGCACGCGCCAC
CCCAAGGAGGTCCCTGTGTCTTTGCAGCCCGTGCTGGACACACTCCTGCAGATGAGTGGCCCCGAAGTCCCCATGGGAGCAGAGAGGGGC
AAGCTGGACCAACTGTTTGAGTACAGGCCTGTCTCCCAGGGCCTGCCCCCACCCTGCCCAAGCCAGCTTCTCAGCCCCTTCAGCTCCGTG
GTTCCCTTCCCACCCTACTTCCCGGCACTGCACAGATTCATCCTCCTGTACCAGGCAAGGCGTGTGGAGGACGAGGCCCAGGGGCGCGAG
CTGGTGTTTGCTCTGTGGCAGCAGCTGGGCGCGGTGCTGAAGGACATCACCCCTGAGGGCCTGGAGATCCTGCTGCCCTTCGTGCTCTCA
CTCATGTCCGAGGAGCACACAGCTGTGTACACGGCCTGGTATCTGTTTGAGCCTGTTGCCAAGGCACTGGGCCCCAAAAATGCCAATAAG
TACCTCCTGAAGCCGCTCATTGGTGCCTACGAGAGCCCCTGCCAGCTACACGGCCGCTTCTACCTGTACACGGACTGCTTTGTGGCCCAG
CTGATGGTGCGGCTGGGCCTGCAGGCATTTCTCACTCACCTGCTGCCCCATGTCCTGCAGGTGCTGGCGGGCGCAGAGGCCTCCCAGGAG
GAGAGCAAGGACCTGGCAGGGGCTGCTGAGGAGGAGGAGAGCGGGCTGCCCGGGGCCGGGCCTGGCTCCTGTGCTTTTGGGGAGGAGATT
CCCATGGATGGGGAGCCTCCTGCCTCCTCGGGCCTGGGGCTCCCAGACTACACGTCTGGCGTCAGCTTCCACGACCAGGCTGACCTCCCT
GAGACAGAGGACTTCCAAGCCGGGCTCTATGTGACTGAGTCTCCCCAGCCCCAGGAGGCTGAGGCTGTGAGCCTGGGCCGGCTGAGTGAC
AAGAGCAGCACCAGCGAGACCTCCCTGGGTGAGGAGCGGGCTCCAGACGAGGGGGGTGCCCCCGTGGACAAGAGCAGCCTTCGATCAGGT
GACAGCAGCCAGGACTTGAAGCAAAGCGAGGGCTCCGAGGAGGAAGAGGAGGAGGAGGACAGCTGCGTGGTGCTAGAGGAGGAGGAGGGG
GAGCAGGAGGAGGTCACCGGGGCATCTGAGCTCACTCTGTCTGACACGGTGCTGTCCATGGAGACGGTTGTGGCCGGCGGCAGTGGGGGA
GATGGAGAAGAAGAGGAGGAGGCACTGCCTGAGCAGTCAGAAGGCAAAGAACAGAAGATCCTCCTTGGGAACCTGCTGCTGAAACCCATC
GTGGAAGTTGCAGGCCAGGATATCAGCCACTGGTTTGATCCAAAGACCAGAGACATCCGCAAGCACATAGATCCGCTGACCGGCTGCCTG
AGGTACTGCACCCCGCGGGGCCGCTTTGTGCACGTTCCGCCTCAGCTGCCCTGTTCGGACTGGGCCAACGATTTTGGGAAGCCCTGGTGG
CAGGGGTCGTATTATGAGGTGGGGCGGCTGTCTGCCAAGACCCGGAGCATCCGCATCATTAACACGCTCACGTCGCAGGAGCACACACTG
GAGGTGGGGGTTCTGGAGTCCATATGGGAAATCCTACACCGCTATCTCCCCTATAACTCACATGCTGCCAGCTACACGTGGAAATATGAA
GGGAAGAACCTGAACATGGATTTTACCCTGGAAGAGAATGGGATCCGGGATGAGGAGGAAGAATTTGACTATCTCAGTATGGACGGTACA
CTTCACACACCTGCAATACTTCTGTACTTCAATGATGATCTCACGGAGTTGTAGGCAAGGAGATGTACACTCGTGTAGACTCAAGACGTA
TTTCGAGTTTGGCTTTTTCTGTGCCTTGAGGAAAAGTGGTGGGGCCGAGGGGTGCCTGGACCCAGATCTCCACTCCTCTCCAGGAGCTAG
CCTGTGCCCTTCTGAAGTGTAAAGGCCCTATTCCCTGCCTTCATTACAGTTTGCTCTGAGAAAATTAGTGAATTAATCTTTGGGAATGAT
ACAAGAAGATCAAGTACCTTGGTTTAGGGAGATGTAGAAGAGGATAGTCAGAGTTCAGGCAGAACTGTTTGATAGTTAAGAGAGAGTAGT
TCTACAGGGGTGAGGGATGGAAGGACTTTTTTGGCAATGATGGAAATGAGATGTCTGCAGGAAGATGGGATTTACAAAGAAATAGGAAAT
GTTTATCATTGACCATACAAAGCTGGCTTATCTTACTTGTAGAAGAGTGTTTGGCAGCTGAAACCCAAGGGAAAGAAAGGAAGTGCGTCA
TTATAGGCAATTCAGGCTAGATATTATACTAGGTACTTCATATACCCTCTTTTTTTTTTTTGCCCCCAACAAAGAGAAGGGGTCTTGCTC
TGTCACCCAGTCTGGAGTGCAGTGGCAAAATCATGGCTCACTGCAGCCTGGAGCTCCTGGGCACAAGTGATCCTCCCATCTCTGCCTTGA
GTAGCTGGGACTTCAGGTGCACGCCACAATGCCTAATTTTTTAATTTTTTGTAGACACAGGGTCTCGCTGTGTTGCCCAGGCTGGTTTCA
ACCTCCTGGCCTCAAGTGATCCTCTTGCCTCAGCCTCCCAAATAGCCTCTTCAAGACAACTACCCCATAAGGTGGATTACCATTACTATG
TTACAGATAAGTCCTTCGAAACTTTGGAAAGTTTAATAGCTCAAAGCCACACTAGGTAGTAACCACTAGAGCCAGAATGCAAATTCAAGT
CTGCCCAACTCCAAAGTCCATGTTCTCTCAATATAAAGGGACCATCTCAATGTCTAATCTCATGTTAACATTTGTAGCCACTGCTCTCAG
CAAGTATTTGGGATGTGGCTTTGTCCTAGGATCCCTGCACAATAGGAAATTGTGGTCCTATTGTATAGTTTGCAGTTATTGTCTCTGGAA
GGGAGTTTGCAGAGTTCTCCTGTGGCGAAGAGGAGGCAAGGAAGGCTAAGTGTCAGTTAAGCAATAGCTATTGGGGCTACTTCTTTGTTA
ATCCCATACCCCAGATTTCTCTCCTGACCTTTTGGGGCAAAGAGGTGGGTATTTACTAACTTGAAGGAAAACTAGAGTGGGGAAAAGGCC
GGCAAATTAGTGACACTTTGGCGAGGGAGAAAAAGGAGGCAGTTTGCCACTTGGAGAAGATGAGGAAGACAGGGTTGCAAGACGGTGACT
CCAAAAGAGGGAGCTCGACAGGGGTAATGTAAACAGAGATGCTAACTAAGTCAGAAAACTCTCCTGGTGACCAAAAGAGAACCACTATTG
GGGGTAATGGCTAGATTTGGTCTCCTTTAACTTAAGGAGGGGAGATTTGAGAATGACAGACAGTTGAACTTCCTGGCAGCAGCAAGCAAA
AAACAAATCAGGAAGAGTTTAGTGTGTCTTCTGGCAGGGGACACCAGGGCCCAGCACAGGAGAAGGTGGCCCCTGTGAGATACTGGTGGG
CTATATAGGCATTTTCTGAGGGGCTTTGGGAGGCATGAACAAAGGTGGAAACATTGCTGTTGGCTTCGGCAGTATCTGAATTTACTGTGA
GATGGAGGGTTTAAATCTAACCCCATGGAATGCAGGAGTCCATGAATTATCTAAATCGATCATTTTGATCTTTAATCAACTCTGCAATTA
TGTGTACCTTGTTTGCTCAATTAAACCCTGAACTATTTGAGAATGAAAGCTATGCTGTTCCTCTAGTGCAAGCCTCAGGGCCTGTCCTGT
GCCTACAGGATGTCCCCATTCTGCCAAAACCTGTCCCTCTTCCAGAGACTCCTACTTCAATGTCTCTTGCTAGAAACACATCCCTTTCCT
CACACATCCAGTCACTCATCAAGTGTAATCTGTCTCCTAAATATCTCTGGAACCTATCTTCTTTTCTCCAAGTTACCATCACCTCTTGTC
TAAACTGCTACGGAAACTTCCTAACCTGTTCTCCCATTTCCACTTCTGACTTCCATGCTGCAATGAGAGTCAGCTATGAAAAACAAACCT
AAACATCGAACTTTCCTTAGCTTCTTCAGTGGCTTCCAACTGCTTTTGGAATAAAGTCCTAAATTCAAAGATCTTGTATAAATCAGGCTC
ATCTCGCAACACCCCTCTTTGTTCTCTATGGCCTAGACACACTGGCTTTCAGTTCATTACATGTCTTGCCTCAGACCCTCACACACTGTC
CTCTCTGCCTGCAACACTCTTCCTTTCACTTTCCACCTAGCTGATCCTAAATGTTCCTTCCTCAGGGAGGTCTTTTCTGATTTCTTGGTG
GGTCAAGACTTTCTGATAAATCAGTTAGCACCATGCATTTTCCAGAGTTTTTATTACAATTGTAAAATTATGGCTGTAATAGGCTGGCTG
CGCTGCTAGATTGTAAGCTCACGAGGGCAGAGATCTTGTTCACATCTTGCTCACTGCTATATTCTCATTGCTGAGCACACAGTTGCAGCT

>99111_99111_3_WDR81-CYB5D1_WDR81_chr17_1631920_ENST00000409644_CYB5D1_chr17_7761721_ENST00000332439_length(amino acids)=1397AA_BP=1194
MAQGSGGREGALRTPAGGWHSPPSPDMQELLRSVERDLSIDPRQLAPAPGGTHVVALVPARWLASLRDRRLPLGPCPRAEGLGEAEVRTL
LQRSVQRLPAGWTRVEVHGLRKRRLSYPLGGGLPFEDGSCGPETLTRFMQEVAAQNYRNLWRHAYHTYGQPYSHSPAPSAVPALDSVRQA
LQRVYGCSFLPVGETTQCPSYAREGPCPPRGSPACPSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFILFRVLRA
MDACHRQGLACGALSLYHIAVDEKLCSELRLDLSAYERPEEDENEEAPVARDEAGIVSQEEQGGQPGQPTGQEELRSLVLDWVHGRISNF
HYLMQLNRLAGRRQGDPNYHPVLPWVVDFTTPHGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITY
YVYKARRTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFRSIHPDMPDLDVPAWCSSSQEFVAAHRALLESREVSRD
LHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLASYGVVQLFDQPHPQRLAGAPALAPEPPLIPKLLVQTIQETTGREDFTENPGQLP
NGVGRPVLEATPCEASWTRDRPVAGEDDLEQATEALDSISLAGKAGDQLGSSSQASPGLLSFSVASASRPGRRNKAAGADPGEGEEGRIL
LPEGFNPMQALEELEKTGNFLAKGLGGLLEVPEQPRVQPAVPLQCLLHRDMQALGVLLAEMVFATRVRTLQPDAPLWVRFQAVRGLCTRH
PKEVPVSLQPVLDTLLQMSGPEVPMGAERGKLDQLFEYRPVSQGLPPPCPSQLLSPFSSVVPFPPYFPALHRFILLYQARRVEDEAQGRE
LVFALWQQLGAVLKDITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLKPLIGAYESPCQLHGRFYLYTDCFVAQ
LMVRLGLQAFLTHLLPHVLQVLAGAEASQEESKDLAGAAEEEESGLPGAGPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFHDQADLP
ETEDFQAGLYVTESPQPQEAEAVSLGRLSDKSSTSETSLGEERAPDEGGAPVDKSSLRSGDSSQDLKQSEGSEEEEEEEDSCVVLEEEEG
EQEEVTGASELTLSDTVLSMETVVAGGSGGDGEEEEEALPEQSEGKEQKILLGNLLLKPIVEVAGQDISHWFDPKTRDIRKHIDPLTGCL
RYCTPRGRFVHVPPQLPCSDWANDFGKPWWQGSYYEVGRLSAKTRSIRIINTLTSQEHTLEVGVLESIWEILHRYLPYNSHAASYTWKYE

--------------------------------------------------------------
>99111_99111_4_WDR81-CYB5D1_WDR81_chr17_1631920_ENST00000409644_CYB5D1_chr17_7761721_ENST00000571846_length(transcript)=4988nt_BP=3667nt
ATGGCCCAGGGCAGCGGGGGGCGGGAAGGCGCTCTCAGAACCCCGGCCGGGGGCTGGCATTCCCCGCCAAGCCCAGACATGCAGGAGCTG
CTCCGGAGCGTGGAGAGGGACCTGAGCATCGATCCCAGGCAGCTGGCTCCGGCCCCGGGGGGCACCCACGTGGTGGCCCTAGTGCCTGCG
CGCTGGCTGGCCAGCCTCCGCGATCGCCGGCTGCCCCTGGGACCCTGTCCCCGCGCAGAGGGCCTGGGAGAAGCGGAAGTCAGGACTCTC
CTGCAGCGCTCTGTGCAAAGGCTGCCTGCCGGCTGGACGCGCGTGGAGGTGCATGGGCTGCGGAAGCGGAGACTGTCCTACCCTCTGGGC
GGGGGCCTGCCCTTTGAGGACGGGTCCTGCGGCCCTGAGACCCTCACTCGCTTCATGCAGGAGGTTGCCGCCCAGAATTATCGCAACCTG
TGGCGCCATGCATACCACACTTACGGCCAGCCGTACAGTCACAGCCCTGCCCCCTCAGCTGTCCCTGCCTTGGACTCAGTACGGCAGGCT
CTGCAGAGGGTCTATGGTTGCTCCTTCCTGCCAGTGGGTGAAACTACCCAATGCCCTTCATATGCCAGAGAAGGCCCCTGCCCCCCTCGG
GGCAGCCCTGCTTGCCCTAGTCTTTTACGGGCTGAGGCCTTGCTGGAGTCGCCGGAGATGCTGTATGTGGTACACCCTTACGTACAGTTC
TCCCTACATGACGTGGTCACCTTCAGCCCTGCCAAGCTGACCAACAGCCAGGCCAAGGTGCTGTTCATTCTCTTCCGCGTGCTGAGGGCT
ATGGACGCCTGTCACCGCCAGGGGCTGGCGTGTGGGGCCCTGTCTTTGTATCACATCGCAGTGGATGAGAAGCTTTGCAGCGAGCTGCGA
CTGGACCTGAGTGCTTATGAGAGGCCCGAGGAGGACGAGAATGAGGAGGCCCCTGTGGCAAGGGATGAGGCGGGCATTGTGTCTCAAGAG
GAGCAGGGAGGGCAACCTGGGCAACCCACTGGCCAGGAGGAACTTCGGAGCCTCGTGCTAGATTGGGTCCACGGCCGCATCAGCAACTTC
CACTACCTCATGCAGCTGAATCGGTTGGCAGGTCGGCGGCAGGGGGACCCCAACTACCACCCCGTGCTGCCCTGGGTGGTGGACTTCACT
ACGCCCCATGGGCGCTTCCGAGACCTGCGCAAGTCCAAGTTCCGCCTCAACAAGGGGGATAAGCAACTGGACTTCACGTATGAGATGACA
CGGCAGGCATTCGTAGCAGGCGGGGCGGGCGGCGGGGAACCCCCTCATGTTCCCCACCACATCTCAGACGTGCTCTCCGACATCACGTAC
TATGTGTACAAGGCTCGGCGCACGCCTCGGTCGGTGCTCTGCGGACACGTCCGCGCGCAGTGGGAGCCCCATGAGTATCCGGCCAGCATG
GAGCGGATGCAGAACTGGACCCCGGATGAGTGCATTCCGGAGTTCTACACCGATCCCTCTATCTTCCGCTCCATCCACCCCGACATGCCT
GACCTGGATGTGCCAGCCTGGTGCAGCTCCAGCCAGGAGTTCGTAGCTGCCCACCGAGCCCTGCTGGAGAGCCGCGAGGTATCCCGGGAC
CTGCACCATTGGATCGACCTCACGTTTGGCTATAAACTCCAGGGTAAGGAGGCTGTCAAGGAAAAGAATGTGTGTCTGCACCTGGTGGAC
GCCCACACTCACCTGGCCAGCTACGGGGTGGTGCAGCTCTTCGATCAGCCACACCCCCAGCGCCTGGCTGGGGCTCCTGCCCTTGCCCCC
GAGCCTCCCCTCATCCCCAAGCTGTTGGTCCAGACCATCCAGGAGACCACAGGCCGGGAGGACTTCACGGAAAACCCGGGACAGCTTCCA
AATGGAGTGGGCCGGCCAGTTTTAGAGGCCACTCCCTGTGAGGCTAGCTGGACCAGAGACAGGCCGGTGGCAGGAGAAGACGACTTGGAA
CAGGCCACAGAAGCTCTGGATTCCATTTCCCTTGCTGGGAAAGCAGGTGACCAGCTGGGCTCCTCCAGTCAAGCGTCCCCTGGACTTCTC
TCTTTCTCAGTGGCCTCAGCCTCCCGTCCAGGCCGCAGGAATAAAGCTGCTGGGGCAGACCCTGGGGAGGGTGAGGAGGGGAGGATTCTT
CTTCCCGAGGGCTTCAATCCCATGCAGGCCCTGGAGGAGCTGGAGAAAACGGGCAACTTCTTGGCCAAAGGCCTAGGGGGCCTGTTGGAG
GTGCCTGAGCAGCCCCGGGTCCAGCCGGCTGTGCCACTGCAGTGCCTACTCCACAGGGACATGCAGGCGCTGGGTGTCCTATTGGCAGAG
ATGGTGTTTGCCACCAGGGTGCGGACGCTGCAGCCCGATGCACCTTTGTGGGTACGCTTCCAGGCTGTCCGAGGGCTCTGCACGCGCCAC
CCCAAGGAGGTCCCTGTGTCTTTGCAGCCCGTGCTGGACACACTCCTGCAGATGAGTGGCCCCGAAGTCCCCATGGGAGCAGAGAGGGGC
AAGCTGGACCAACTGTTTGAGTACAGGCCTGTCTCCCAGGGCCTGCCCCCACCCTGCCCAAGCCAGCTTCTCAGCCCCTTCAGCTCCGTG
GTTCCCTTCCCACCCTACTTCCCGGCACTGCACAGATTCATCCTCCTGTACCAGGCAAGGCGTGTGGAGGACGAGGCCCAGGGGCGCGAG
CTGGTGTTTGCTCTGTGGCAGCAGCTGGGCGCGGTGCTGAAGGACATCACCCCTGAGGGCCTGGAGATCCTGCTGCCCTTCGTGCTCTCA
CTCATGTCCGAGGAGCACACAGCTGTGTACACGGCCTGGTATCTGTTTGAGCCTGTTGCCAAGGCACTGGGCCCCAAAAATGCCAATAAG
TACCTCCTGAAGCCGCTCATTGGTGCCTACGAGAGCCCCTGCCAGCTACACGGCCGCTTCTACCTGTACACGGACTGCTTTGTGGCCCAG
CTGATGGTGCGGCTGGGCCTGCAGGCATTTCTCACTCACCTGCTGCCCCATGTCCTGCAGGTGCTGGCGGGCGCAGAGGCCTCCCAGGAG
GAGAGCAAGGACCTGGCAGGGGCTGCTGAGGAGGAGGAGAGCGGGCTGCCCGGGGCCGGGCCTGGCTCCTGTGCTTTTGGGGAGGAGATT
CCCATGGATGGGGAGCCTCCTGCCTCCTCGGGCCTGGGGCTCCCAGACTACACGTCTGGCGTCAGCTTCCACGACCAGGCTGACCTCCCT
GAGACAGAGGACTTCCAAGCCGGGCTCTATGTGACTGAGTCTCCCCAGCCCCAGGAGGCTGAGGCTGTGAGCCTGGGCCGGCTGAGTGAC
AAGAGCAGCACCAGCGAGACCTCCCTGGGTGAGGAGCGGGCTCCAGACGAGGGGGGTGCCCCCGTGGACAAGAGCAGCCTTCGATCAGGT
GACAGCAGCCAGGACTTGAAGCAAAGCGAGGGCTCCGAGGAGGAAGAGGAGGAGGAGGACAGCTGCGTGGTGCTAGAGGAGGAGGAGGGG
GAGCAGGAGGAGGTCACCGGGGCATCTGAGCTCACTCTGTCTGACACGGTGCTGTCCATGGAGACGGTTGTGGCCGGCGGCAGTGGGGGA
GATGGAGAAGAAGAGGAGGAGGCACTGCCTGAGCAGTCAGAAGGCAAAGAACAGAAGATCCTCCTTGGGAACCTGCTGCTGAAACCCATC
GTGGAAGTTGCAGGCCAGGATATCAGCCACTGGTTTGATCCAAAGACCAGAGACATCCGCAAGCACATAGATCCGCTGACCGGCTGCCTG
AGGTACTGCACCCCGCGGGGCCGCTTTGTGCACGTTCCGCCTCAGCTGCCCTGTTCGGACTGGGCCAACGATTTTGGGAAGCCCTGGTGG
CAGGGGTCGTATTATGAGGTGGGGCGGCTGTCTGCCAAGACCCGGAGCATCCGCATCATTAACACGCTCACGTCGCAGGAGCACACACTG
GAGCTACACGTGGAAATATGAAGGGAAGAACCTGAACATGGATTTTACCCTGGAAGAGAATGGGATCCGGGATGAGGAGGAAGAATTTGA
CTATCTCAGTATGGACGGTACACTTCACACACCTGCAATACTTCTGTACTTCAATGATGATCTCACGGAGTTGTAGGCAAGGAGATGTAC
ACTCGTGTAGACTCAAGACGTATTTCGAGTTTGGCTTTTTCTGTGCCTTGAGGAAAAGTGGTGGGGCCGAGGGGTGCCTGGACCCAGATC
TCCACTCCTCTCCAGGAGCTAGCCTGTGCCCTTCTGAAGTGTAAAGGCCCTATTCCCTGCCTTCATTACAGTTTGCTCTGAGAAAATTAG
TGAATTAATCTTTGGGAATGATACAAGAAGATCAAGTACCTTGGTTTAGGGAGATGTAGAAGAGGATAGTCAGAGTTCAGGCAGAACTGT
TTGATAGTTAAGAGAGAGTAGTTCTACAGGGGTGAGGGATGGAAGGACTTTTTTGGCAATGATGGAAATGAGATGTCTGCAGGAAGATGG
GATTTACAAAGAAATAGGAAATGTTTATCATTGACCATACAAAGCTGGCTTATCTTACTTGTAGAAGAGTGTTTGGCAGCTGAAACCCAA
GGGAAAGAAAGGAAGTGCGTCATTATAGGCAATTCAGGCTAGATATTATACTAGGTACTTCATATACCCTCTTTTTTTTTTTTGCCCCCA
ACAAAGAGAAGGGGTCTTGCTCTGTCACCCAGTCTGGAGTGCAGTGGCAAAATCATGGCTCACTGCAGCCTGGAGCTCCTGGGCACAAGT
GATCCTCCCATCTCTGCCTTGAGTAGCTGGGACTTCAGGTGCACGCCACAATGCCTAATTTTTTAATTTTTTGTAGACACAGGGTCTCGC
TGTGTTGCCCAGGCTGGTTTCAACCTCCTGGCCTCAAGTGATCCTCTTGCCTCAGCCTCCCAAATAGCCTCTTCAAGACAACTACCCCAT

>99111_99111_4_WDR81-CYB5D1_WDR81_chr17_1631920_ENST00000409644_CYB5D1_chr17_7761721_ENST00000571846_length(amino acids)=1326AA_BP=1194
MAQGSGGREGALRTPAGGWHSPPSPDMQELLRSVERDLSIDPRQLAPAPGGTHVVALVPARWLASLRDRRLPLGPCPRAEGLGEAEVRTL
LQRSVQRLPAGWTRVEVHGLRKRRLSYPLGGGLPFEDGSCGPETLTRFMQEVAAQNYRNLWRHAYHTYGQPYSHSPAPSAVPALDSVRQA
LQRVYGCSFLPVGETTQCPSYAREGPCPPRGSPACPSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFILFRVLRA
MDACHRQGLACGALSLYHIAVDEKLCSELRLDLSAYERPEEDENEEAPVARDEAGIVSQEEQGGQPGQPTGQEELRSLVLDWVHGRISNF
HYLMQLNRLAGRRQGDPNYHPVLPWVVDFTTPHGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITY
YVYKARRTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFRSIHPDMPDLDVPAWCSSSQEFVAAHRALLESREVSRD
LHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLASYGVVQLFDQPHPQRLAGAPALAPEPPLIPKLLVQTIQETTGREDFTENPGQLP
NGVGRPVLEATPCEASWTRDRPVAGEDDLEQATEALDSISLAGKAGDQLGSSSQASPGLLSFSVASASRPGRRNKAAGADPGEGEEGRIL
LPEGFNPMQALEELEKTGNFLAKGLGGLLEVPEQPRVQPAVPLQCLLHRDMQALGVLLAEMVFATRVRTLQPDAPLWVRFQAVRGLCTRH
PKEVPVSLQPVLDTLLQMSGPEVPMGAERGKLDQLFEYRPVSQGLPPPCPSQLLSPFSSVVPFPPYFPALHRFILLYQARRVEDEAQGRE
LVFALWQQLGAVLKDITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLKPLIGAYESPCQLHGRFYLYTDCFVAQ
LMVRLGLQAFLTHLLPHVLQVLAGAEASQEESKDLAGAAEEEESGLPGAGPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFHDQADLP
ETEDFQAGLYVTESPQPQEAEAVSLGRLSDKSSTSETSLGEERAPDEGGAPVDKSSLRSGDSSQDLKQSEGSEEEEEEEDSCVVLEEEEG
EQEEVTGASELTLSDTVLSMETVVAGGSGGDGEEEEEALPEQSEGKEQKILLGNLLLKPIVEVAGQDISHWFDPKTRDIRKHIDPLTGCL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WDR81-CYB5D1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WDR81-CYB5D1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WDR81-CYB5D1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource