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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WDR83-DHPS (FusionGDB2 ID:99124)

Fusion Gene Summary for WDR83-DHPS

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR83-DHPS
Fusion gene ID: 99124
HgeneTgene
Gene symbol

WDR83

DHPS

Gene ID

84292

1725

Gene nameWD repeat domain 83deoxyhypusine synthase
SynonymsMORG1DHS|DS|MIG13|NEDSSWI
Cytomap

19p13.13

19p13.13

Type of geneprotein-codingprotein-coding
DescriptionWD repeat domain-containing protein 83MAPK organizer 1mitogen-activated protein kinase organizer 1deoxyhypusine synthasemigration-inducing gene 13
Modification date2020031320200327
UniProtAcc.

P49366

Ensembl transtripts involved in fusion geneENST00000242796, ENST00000418543, 
ENST00000210060, ENST00000351660, 
ENST00000594424, ENST00000599481, 
Fusion gene scores* DoF score1 X 16 X 12=1924 X 25 X 12=1200
# samples 2529
** MAII scorelog2(25/192*10)=0.380821783940931
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(29/1200*10)=-2.04890960048095
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR83 [Title/Abstract] AND DHPS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDR83(12786747)-DHPS(12786831), # samples:3
Anticipated loss of major functional domain due to fusion event.WDR83-DHPS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WDR83-DHPS seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
WDR83-DHPS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWDR83

GO:0000375

RNA splicing, via transesterification reactions

11991638

HgeneWDR83

GO:0000398

mRNA splicing, via spliceosome

11991638

TgeneDHPS

GO:0008216

spermidine metabolic process

23525104

TgeneDHPS

GO:0008612

peptidyl-lysine modification to peptidyl-hypusine

23525104


check buttonFusion gene breakpoints across WDR83 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DHPS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CF-A47V-01AWDR83chr19

12786594

-DHPSchr19

12786873

-
ChimerDB4BLCATCGA-S5-AA26-01AWDR83chr19

12786619

-DHPSchr19

12786856

-
ChimerDB4BRCATCGA-BH-A28O-01AWDR83chr19

12786620

-DHPSchr19

12787983

-
ChimerDB4BRCATCGA-LD-A7W6-01AWDR83chr19

12786619

-DHPSchr19

12786871

-
ChimerDB4CESCTCGA-DG-A2KH-01AWDR83chr19

12786635

-DHPSchr19

12786913

-
ChimerDB4CESCTCGA-EK-A3GM-01AWDR83chr19

12786621

-DHPSchr19

12786881

-
ChimerDB4CESCTCGA-EK-A3GN-01AWDR83chr19

12786620

-DHPSchr19

12786854

-
ChimerDB4CESCTCGA-EX-A1H5-01AWDR83chr19

12786568

-DHPSchr19

12786852

-
ChimerDB4CESCTCGA-FU-A23K-01AWDR83chr19

12786621

-DHPSchr19

12786852

-
ChimerDB4CESCTCGA-MY-A913-01AWDR83chr19

12786617

-DHPSchr19

12786871

-
ChimerDB4KIRCTCGA-BP-4992-01AWDR83chr19

12786619

-DHPSchr19

12786874

-
ChimerDB4LGGTCGA-DB-A75O-01AWDR83chr19

12786617

-DHPSchr19

12788153

-
ChimerDB4LUSCTCGA-56-A4BX-01AWDR83chr19

12786390

-DHPSchr19

12786688

-
ChimerDB4LUSCTCGA-56-A4BX-01AWDR83chr19

12786617

-DHPSchr19

12786854

-
ChimerDB4LUSCTCGA-96-7545-01AWDR83chr19

12786614

-DHPSchr19

12787966

-
ChimerDB4OVTCGA-29-A5NZ-01AWDR83chr19

12786455

+DHPSchr19

12786734

-
ChimerDB4OVTCGA-31-1951-01AWDR83chr19

12786631

-DHPSchr19

12788070

-
ChimerDB4PRADTCGA-EJ-7325-01BWDR83chr19

12786619

-DHPSchr19

12786856

-
ChimerDB4PRADTCGA-HC-8261-01AWDR83chr19

12786642

+DHPSchr19

12786854

-
ChimerDB4PRADTCGA-HC-8265-01AWDR83chr19

12786564

-DHPSchr19

12786851

-
ChimerDB4PRADTCGA-ZG-A9L0-01AWDR83chr19

12786620

-DHPSchr19

12786854

-
ChimerDB4SARCTCGA-DX-A3UF-01AWDR83chr19

12786620

-DHPSchr19

12786852

-
ChimerDB4SARCTCGA-IW-A3M5-01AWDR83chr19

12786623

-DHPSchr19

12787950

-
ChimerDB4STADTCGA-2H-A9GJ-01A7WDR83chr19

12786619

-DHPSchr19

12788150

-
ChimerDB4STADTCGA-L5-A4OR-01A4WDR83chr19

12786594

+DHPSchr19

12792478

-
ChimerDB4STADTCGA-R6-A8WC-01A6WDR83chr19

12786614

-DHPSchr19

12787966

-
ChimerDB4THYMTCGA-4V-A9QN-01AWDR83chr19

12786635

-DHPSchr19

12786913

-
ChimerDB4UCECTCGA-A5-A1OH-01AWDR83chr19

12786620

-DHPSchr19

12786876

-
ChimerDB4UCECTCGA-EY-A2OQ-01AWDR83chr19

12786597

-DHPSchr19

12786855

-
ChiTaRS5.0N/ABF591524WDR83chr19

12786747

+DHPSchr19

12786831

+
ChiTaRS5.0N/ABF940778WDR83chr19

12786747

+DHPSchr19

12786831

+
ChiTaRS5.0N/ABG222923WDR83chr19

12786747

+DHPSchr19

12786831

+


Top

Fusion Gene ORF analysis for WDR83-DHPS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786594

-DHPSchr19

12786873

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786619

-DHPSchr19

12786856

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786620

-DHPSchr19

12787983

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786619

-DHPSchr19

12786871

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786635

-DHPSchr19

12786913

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786621

-DHPSchr19

12786881

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786620

-DHPSchr19

12786854

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786568

-DHPSchr19

12786852

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786621

-DHPSchr19

12786852

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786617

-DHPSchr19

12786871

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786619

-DHPSchr19

12786874

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786617

-DHPSchr19

12788153

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786617

-DHPSchr19

12786854

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786564

-DHPSchr19

12786851

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786620

-DHPSchr19

12786852

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786623

-DHPSchr19

12787950

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786619

-DHPSchr19

12788150

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786594

+DHPSchr19

12792478

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786614

-DHPSchr19

12787966

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786620

-DHPSchr19

12786876

-
3UTR-3CDSENST00000242796ENST00000210060WDR83chr19

12786597

-DHPSchr19

12786855

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786594

-DHPSchr19

12786873

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786619

-DHPSchr19

12786856

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786619

-DHPSchr19

12786871

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786635

-DHPSchr19

12786913

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786621

-DHPSchr19

12786881

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786620

-DHPSchr19

12786854

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786568

-DHPSchr19

12786852

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786621

-DHPSchr19

12786852

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786617

-DHPSchr19

12786871

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786619

-DHPSchr19

12786874

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786617

-DHPSchr19

12788153

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786617

-DHPSchr19

12786854

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786564

-DHPSchr19

12786851

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786620

-DHPSchr19

12786852

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786619

-DHPSchr19

12788150

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786594

+DHPSchr19

12792478

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786620

-DHPSchr19

12786876

-
3UTR-3CDSENST00000242796ENST00000351660WDR83chr19

12786597

-DHPSchr19

12786855

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786594

-DHPSchr19

12786873

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786619

-DHPSchr19

12786856

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786619

-DHPSchr19

12786871

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786635

-DHPSchr19

12786913

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786621

-DHPSchr19

12786881

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786620

-DHPSchr19

12786854

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786568

-DHPSchr19

12786852

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786621

-DHPSchr19

12786852

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786617

-DHPSchr19

12786871

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786619

-DHPSchr19

12786874

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786617

-DHPSchr19

12788153

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786617

-DHPSchr19

12786854

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786564

-DHPSchr19

12786851

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786620

-DHPSchr19

12786852

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786619

-DHPSchr19

12788150

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786620

-DHPSchr19

12786876

-
3UTR-3CDSENST00000242796ENST00000594424WDR83chr19

12786597

-DHPSchr19

12786855

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786594

-DHPSchr19

12786873

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786619

-DHPSchr19

12786856

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786620

-DHPSchr19

12787983

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786619

-DHPSchr19

12786871

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786635

-DHPSchr19

12786913

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786621

-DHPSchr19

12786881

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786620

-DHPSchr19

12786854

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786568

-DHPSchr19

12786852

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786621

-DHPSchr19

12786852

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786617

-DHPSchr19

12786871

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786619

-DHPSchr19

12786874

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786617

-DHPSchr19

12788153

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786617

-DHPSchr19

12786854

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786564

-DHPSchr19

12786851

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786620

-DHPSchr19

12786852

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786623

-DHPSchr19

12787950

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786619

-DHPSchr19

12788150

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786594

+DHPSchr19

12792478

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786614

-DHPSchr19

12787966

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786620

-DHPSchr19

12786876

-
3UTR-3CDSENST00000418543ENST00000210060WDR83chr19

12786597

-DHPSchr19

12786855

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786594

-DHPSchr19

12786873

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786619

-DHPSchr19

12786856

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786619

-DHPSchr19

12786871

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786635

-DHPSchr19

12786913

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786621

-DHPSchr19

12786881

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786620

-DHPSchr19

12786854

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786568

-DHPSchr19

12786852

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786621

-DHPSchr19

12786852

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786617

-DHPSchr19

12786871

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786619

-DHPSchr19

12786874

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786617

-DHPSchr19

12788153

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786617

-DHPSchr19

12786854

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786564

-DHPSchr19

12786851

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786620

-DHPSchr19

12786852

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786619

-DHPSchr19

12788150

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786594

+DHPSchr19

12792478

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786620

-DHPSchr19

12786876

-
3UTR-3CDSENST00000418543ENST00000351660WDR83chr19

12786597

-DHPSchr19

12786855

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786594

-DHPSchr19

12786873

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786619

-DHPSchr19

12786856

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786619

-DHPSchr19

12786871

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786635

-DHPSchr19

12786913

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786621

-DHPSchr19

12786881

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786620

-DHPSchr19

12786854

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786568

-DHPSchr19

12786852

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786621

-DHPSchr19

12786852

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786617

-DHPSchr19

12786871

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786619

-DHPSchr19

12786874

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786617

-DHPSchr19

12788153

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786617

-DHPSchr19

12786854

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786564

-DHPSchr19

12786851

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786620

-DHPSchr19

12786852

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786619

-DHPSchr19

12788150

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786620

-DHPSchr19

12786876

-
3UTR-3CDSENST00000418543ENST00000594424WDR83chr19

12786597

-DHPSchr19

12786855

-
3UTR-intronENST00000242796ENST00000210060WDR83chr19

12786631

-DHPSchr19

12788070

-
3UTR-intronENST00000242796ENST00000351660WDR83chr19

12786620

-DHPSchr19

12787983

-
3UTR-intronENST00000242796ENST00000351660WDR83chr19

12786631

-DHPSchr19

12788070

-
3UTR-intronENST00000242796ENST00000351660WDR83chr19

12786623

-DHPSchr19

12787950

-
3UTR-intronENST00000242796ENST00000351660WDR83chr19

12786614

-DHPSchr19

12787966

-
3UTR-intronENST00000242796ENST00000594424WDR83chr19

12786620

-DHPSchr19

12787983

-
3UTR-intronENST00000242796ENST00000594424WDR83chr19

12786631

-DHPSchr19

12788070

-
3UTR-intronENST00000242796ENST00000594424WDR83chr19

12786623

-DHPSchr19

12787950

-
3UTR-intronENST00000242796ENST00000594424WDR83chr19

12786594

+DHPSchr19

12792478

-
3UTR-intronENST00000242796ENST00000594424WDR83chr19

12786614

-DHPSchr19

12787966

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786594

-DHPSchr19

12786873

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786619

-DHPSchr19

12786856

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786620

-DHPSchr19

12787983

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786619

-DHPSchr19

12786871

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786635

-DHPSchr19

12786913

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786621

-DHPSchr19

12786881

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786620

-DHPSchr19

12786854

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786568

-DHPSchr19

12786852

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786621

-DHPSchr19

12786852

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786617

-DHPSchr19

12786871

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786619

-DHPSchr19

12786874

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786617

-DHPSchr19

12788153

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786617

-DHPSchr19

12786854

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786631

-DHPSchr19

12788070

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786564

-DHPSchr19

12786851

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786620

-DHPSchr19

12786852

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786623

-DHPSchr19

12787950

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786619

-DHPSchr19

12788150

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786594

+DHPSchr19

12792478

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786614

-DHPSchr19

12787966

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786620

-DHPSchr19

12786876

-
3UTR-intronENST00000242796ENST00000599481WDR83chr19

12786597

-DHPSchr19

12786855

-
3UTR-intronENST00000418543ENST00000210060WDR83chr19

12786631

-DHPSchr19

12788070

-
3UTR-intronENST00000418543ENST00000351660WDR83chr19

12786620

-DHPSchr19

12787983

-
3UTR-intronENST00000418543ENST00000351660WDR83chr19

12786631

-DHPSchr19

12788070

-
3UTR-intronENST00000418543ENST00000351660WDR83chr19

12786623

-DHPSchr19

12787950

-
3UTR-intronENST00000418543ENST00000351660WDR83chr19

12786614

-DHPSchr19

12787966

-
3UTR-intronENST00000418543ENST00000594424WDR83chr19

12786620

-DHPSchr19

12787983

-
3UTR-intronENST00000418543ENST00000594424WDR83chr19

12786631

-DHPSchr19

12788070

-
3UTR-intronENST00000418543ENST00000594424WDR83chr19

12786623

-DHPSchr19

12787950

-
3UTR-intronENST00000418543ENST00000594424WDR83chr19

12786594

+DHPSchr19

12792478

-
3UTR-intronENST00000418543ENST00000594424WDR83chr19

12786614

-DHPSchr19

12787966

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786594

-DHPSchr19

12786873

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786619

-DHPSchr19

12786856

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786620

-DHPSchr19

12787983

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786619

-DHPSchr19

12786871

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786635

-DHPSchr19

12786913

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786621

-DHPSchr19

12786881

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786620

-DHPSchr19

12786854

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786568

-DHPSchr19

12786852

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786621

-DHPSchr19

12786852

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786617

-DHPSchr19

12786871

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786619

-DHPSchr19

12786874

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786617

-DHPSchr19

12788153

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786617

-DHPSchr19

12786854

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786631

-DHPSchr19

12788070

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786564

-DHPSchr19

12786851

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786620

-DHPSchr19

12786852

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786623

-DHPSchr19

12787950

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786619

-DHPSchr19

12788150

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786594

+DHPSchr19

12792478

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786614

-DHPSchr19

12787966

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786620

-DHPSchr19

12786876

-
3UTR-intronENST00000418543ENST00000599481WDR83chr19

12786597

-DHPSchr19

12786855

-
5CDS-intronENST00000242796ENST00000599481WDR83chr19

12786390

-DHPSchr19

12786688

-
5CDS-intronENST00000242796ENST00000599481WDR83chr19

12786455

+DHPSchr19

12786734

-
5CDS-intronENST00000242796ENST00000599481WDR83chr19

12786642

+DHPSchr19

12786854

-
5CDS-intronENST00000418543ENST00000599481WDR83chr19

12786390

-DHPSchr19

12786688

-
5CDS-intronENST00000418543ENST00000599481WDR83chr19

12786455

+DHPSchr19

12786734

-
5CDS-intronENST00000418543ENST00000599481WDR83chr19

12786642

+DHPSchr19

12786854

-
Frame-shiftENST00000242796ENST00000210060WDR83chr19

12786390

-DHPSchr19

12786688

-
Frame-shiftENST00000242796ENST00000210060WDR83chr19

12786455

+DHPSchr19

12786734

-
Frame-shiftENST00000242796ENST00000351660WDR83chr19

12786642

+DHPSchr19

12786854

-
Frame-shiftENST00000242796ENST00000594424WDR83chr19

12786390

-DHPSchr19

12786688

-
Frame-shiftENST00000242796ENST00000594424WDR83chr19

12786455

+DHPSchr19

12786734

-
Frame-shiftENST00000418543ENST00000210060WDR83chr19

12786642

+DHPSchr19

12786854

-
Frame-shiftENST00000418543ENST00000351660WDR83chr19

12786390

-DHPSchr19

12786688

-
Frame-shiftENST00000418543ENST00000351660WDR83chr19

12786455

+DHPSchr19

12786734

-
Frame-shiftENST00000418543ENST00000594424WDR83chr19

12786642

+DHPSchr19

12786854

-
In-frameENST00000242796ENST00000210060WDR83chr19

12786642

+DHPSchr19

12786854

-
In-frameENST00000242796ENST00000351660WDR83chr19

12786390

-DHPSchr19

12786688

-
In-frameENST00000242796ENST00000351660WDR83chr19

12786455

+DHPSchr19

12786734

-
In-frameENST00000242796ENST00000594424WDR83chr19

12786642

+DHPSchr19

12786854

-
In-frameENST00000418543ENST00000210060WDR83chr19

12786390

-DHPSchr19

12786688

-
In-frameENST00000418543ENST00000210060WDR83chr19

12786455

+DHPSchr19

12786734

-
In-frameENST00000418543ENST00000351660WDR83chr19

12786642

+DHPSchr19

12786854

-
In-frameENST00000418543ENST00000594424WDR83chr19

12786390

-DHPSchr19

12786688

-
In-frameENST00000418543ENST00000594424WDR83chr19

12786455

+DHPSchr19

12786734

-
intron-intronENST00000242796ENST00000210060WDR83chr19

12786747

+DHPSchr19

12786831

+
intron-intronENST00000242796ENST00000351660WDR83chr19

12786747

+DHPSchr19

12786831

+
intron-intronENST00000242796ENST00000594424WDR83chr19

12786747

+DHPSchr19

12786831

+
intron-intronENST00000242796ENST00000599481WDR83chr19

12786747

+DHPSchr19

12786831

+
intron-intronENST00000418543ENST00000210060WDR83chr19

12786747

+DHPSchr19

12786831

+
intron-intronENST00000418543ENST00000351660WDR83chr19

12786747

+DHPSchr19

12786831

+
intron-intronENST00000418543ENST00000594424WDR83chr19

12786747

+DHPSchr19

12786831

+
intron-intronENST00000418543ENST00000599481WDR83chr19

12786747

+DHPSchr19

12786831

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for WDR83-DHPS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for WDR83-DHPS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:12786747/chr19:12786831)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DHPS

P49366

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. {ECO:0000269|PubMed:30661771}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR83chr19:12786642chr19:12786854ENST00000242796+99107_146369316.0RepeatNote=WD 3
HgeneWDR83chr19:12786642chr19:12786854ENST00000242796+99151_188369316.0RepeatNote=WD 4
HgeneWDR83chr19:12786642chr19:12786854ENST00000242796+99190_228369316.0RepeatNote=WD 5
HgeneWDR83chr19:12786642chr19:12786854ENST00000242796+99231_272369316.0RepeatNote=WD 6
HgeneWDR83chr19:12786642chr19:12786854ENST00000242796+9923_62369316.0RepeatNote=WD 1
HgeneWDR83chr19:12786642chr19:12786854ENST00000242796+99275_313369316.0RepeatNote=WD 7
HgeneWDR83chr19:12786642chr19:12786854ENST00000242796+9965_104369316.0RepeatNote=WD 2
HgeneWDR83chr19:12786642chr19:12786854ENST00000418543+1111107_146369316.0RepeatNote=WD 3
HgeneWDR83chr19:12786642chr19:12786854ENST00000418543+1111151_188369316.0RepeatNote=WD 4
HgeneWDR83chr19:12786642chr19:12786854ENST00000418543+1111190_228369316.0RepeatNote=WD 5
HgeneWDR83chr19:12786642chr19:12786854ENST00000418543+1111231_272369316.0RepeatNote=WD 6
HgeneWDR83chr19:12786642chr19:12786854ENST00000418543+111123_62369316.0RepeatNote=WD 1
HgeneWDR83chr19:12786642chr19:12786854ENST00000418543+1111275_313369316.0RepeatNote=WD 7
HgeneWDR83chr19:12786642chr19:12786854ENST00000418543+111165_104369316.0RepeatNote=WD 2
TgeneDHPSchr19:12786390chr19:12786688ENST0000021006009131_1330370.0Nucleotide bindingNAD
TgeneDHPSchr19:12786390chr19:12786688ENST0000021006009308_3090370.0Nucleotide bindingNAD
TgeneDHPSchr19:12786390chr19:12786688ENST0000021006009342_3430370.0Nucleotide bindingNAD
TgeneDHPSchr19:12786390chr19:12786688ENST0000035166008131_1330323.0Nucleotide bindingNAD
TgeneDHPSchr19:12786390chr19:12786688ENST0000035166008308_3090323.0Nucleotide bindingNAD
TgeneDHPSchr19:12786390chr19:12786688ENST0000035166008342_3430323.0Nucleotide bindingNAD
TgeneDHPSchr19:12786390chr19:12786688ENST0000059442409131_1330328.0Nucleotide bindingNAD
TgeneDHPSchr19:12786390chr19:12786688ENST0000059442409308_3090328.0Nucleotide bindingNAD
TgeneDHPSchr19:12786390chr19:12786688ENST0000059442409342_3430328.0Nucleotide bindingNAD
TgeneDHPSchr19:12786455chr19:12786734ENST0000021006009131_1330370.0Nucleotide bindingNAD
TgeneDHPSchr19:12786455chr19:12786734ENST0000021006009308_3090370.0Nucleotide bindingNAD
TgeneDHPSchr19:12786455chr19:12786734ENST0000021006009342_3430370.0Nucleotide bindingNAD
TgeneDHPSchr19:12786455chr19:12786734ENST0000035166008131_1330323.0Nucleotide bindingNAD
TgeneDHPSchr19:12786455chr19:12786734ENST0000035166008308_3090323.0Nucleotide bindingNAD
TgeneDHPSchr19:12786455chr19:12786734ENST0000035166008342_3430323.0Nucleotide bindingNAD
TgeneDHPSchr19:12786455chr19:12786734ENST0000059442409131_1330328.0Nucleotide bindingNAD
TgeneDHPSchr19:12786455chr19:12786734ENST0000059442409308_3090328.0Nucleotide bindingNAD
TgeneDHPSchr19:12786455chr19:12786734ENST0000059442409342_3430328.0Nucleotide bindingNAD
TgeneDHPSchr19:12786642chr19:12786854ENST0000021006009131_1330370.0Nucleotide bindingNAD
TgeneDHPSchr19:12786642chr19:12786854ENST0000021006009308_3090370.0Nucleotide bindingNAD
TgeneDHPSchr19:12786642chr19:12786854ENST0000021006009342_3430370.0Nucleotide bindingNAD
TgeneDHPSchr19:12786642chr19:12786854ENST0000035166008131_1330323.0Nucleotide bindingNAD
TgeneDHPSchr19:12786642chr19:12786854ENST0000035166008308_3090323.0Nucleotide bindingNAD
TgeneDHPSchr19:12786642chr19:12786854ENST0000035166008342_3430323.0Nucleotide bindingNAD
TgeneDHPSchr19:12786642chr19:12786854ENST0000059442409131_1330328.0Nucleotide bindingNAD
TgeneDHPSchr19:12786642chr19:12786854ENST0000059442409308_3090328.0Nucleotide bindingNAD
TgeneDHPSchr19:12786642chr19:12786854ENST0000059442409342_3430328.0Nucleotide bindingNAD
TgeneDHPSchr19:12786390chr19:12786688ENST0000021006009136_1370370.0RegionSpermidine binding
TgeneDHPSchr19:12786390chr19:12786688ENST0000021006009314_3160370.0RegionSpermidine binding
TgeneDHPSchr19:12786390chr19:12786688ENST0000021006009323_3290370.0RegionSpermidine binding
TgeneDHPSchr19:12786390chr19:12786688ENST0000035166008136_1370323.0RegionSpermidine binding
TgeneDHPSchr19:12786390chr19:12786688ENST0000035166008314_3160323.0RegionSpermidine binding
TgeneDHPSchr19:12786390chr19:12786688ENST0000035166008323_3290323.0RegionSpermidine binding
TgeneDHPSchr19:12786390chr19:12786688ENST0000059442409136_1370328.0RegionSpermidine binding
TgeneDHPSchr19:12786390chr19:12786688ENST0000059442409314_3160328.0RegionSpermidine binding
TgeneDHPSchr19:12786390chr19:12786688ENST0000059442409323_3290328.0RegionSpermidine binding
TgeneDHPSchr19:12786455chr19:12786734ENST0000021006009136_1370370.0RegionSpermidine binding
TgeneDHPSchr19:12786455chr19:12786734ENST0000021006009314_3160370.0RegionSpermidine binding
TgeneDHPSchr19:12786455chr19:12786734ENST0000021006009323_3290370.0RegionSpermidine binding
TgeneDHPSchr19:12786455chr19:12786734ENST0000035166008136_1370323.0RegionSpermidine binding
TgeneDHPSchr19:12786455chr19:12786734ENST0000035166008314_3160323.0RegionSpermidine binding
TgeneDHPSchr19:12786455chr19:12786734ENST0000035166008323_3290323.0RegionSpermidine binding
TgeneDHPSchr19:12786455chr19:12786734ENST0000059442409136_1370328.0RegionSpermidine binding
TgeneDHPSchr19:12786455chr19:12786734ENST0000059442409314_3160328.0RegionSpermidine binding
TgeneDHPSchr19:12786455chr19:12786734ENST0000059442409323_3290328.0RegionSpermidine binding
TgeneDHPSchr19:12786642chr19:12786854ENST0000021006009136_1370370.0RegionSpermidine binding
TgeneDHPSchr19:12786642chr19:12786854ENST0000021006009314_3160370.0RegionSpermidine binding
TgeneDHPSchr19:12786642chr19:12786854ENST0000021006009323_3290370.0RegionSpermidine binding
TgeneDHPSchr19:12786642chr19:12786854ENST0000035166008136_1370323.0RegionSpermidine binding
TgeneDHPSchr19:12786642chr19:12786854ENST0000035166008314_3160323.0RegionSpermidine binding
TgeneDHPSchr19:12786642chr19:12786854ENST0000035166008323_3290323.0RegionSpermidine binding
TgeneDHPSchr19:12786642chr19:12786854ENST0000059442409136_1370328.0RegionSpermidine binding
TgeneDHPSchr19:12786642chr19:12786854ENST0000059442409314_3160328.0RegionSpermidine binding
TgeneDHPSchr19:12786642chr19:12786854ENST0000059442409323_3290328.0RegionSpermidine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR83chr19:12786390chr19:12786688ENST00000242796-19107_1460316.0RepeatNote=WD 3
HgeneWDR83chr19:12786390chr19:12786688ENST00000242796-19151_1880316.0RepeatNote=WD 4
HgeneWDR83chr19:12786390chr19:12786688ENST00000242796-19190_2280316.0RepeatNote=WD 5
HgeneWDR83chr19:12786390chr19:12786688ENST00000242796-19231_2720316.0RepeatNote=WD 6
HgeneWDR83chr19:12786390chr19:12786688ENST00000242796-1923_620316.0RepeatNote=WD 1
HgeneWDR83chr19:12786390chr19:12786688ENST00000242796-19275_3130316.0RepeatNote=WD 7
HgeneWDR83chr19:12786390chr19:12786688ENST00000242796-1965_1040316.0RepeatNote=WD 2
HgeneWDR83chr19:12786390chr19:12786688ENST00000418543-111107_1460316.0RepeatNote=WD 3
HgeneWDR83chr19:12786390chr19:12786688ENST00000418543-111151_1880316.0RepeatNote=WD 4
HgeneWDR83chr19:12786390chr19:12786688ENST00000418543-111190_2280316.0RepeatNote=WD 5
HgeneWDR83chr19:12786390chr19:12786688ENST00000418543-111231_2720316.0RepeatNote=WD 6
HgeneWDR83chr19:12786390chr19:12786688ENST00000418543-11123_620316.0RepeatNote=WD 1
HgeneWDR83chr19:12786390chr19:12786688ENST00000418543-111275_3130316.0RepeatNote=WD 7
HgeneWDR83chr19:12786390chr19:12786688ENST00000418543-11165_1040316.0RepeatNote=WD 2
HgeneWDR83chr19:12786455chr19:12786734ENST00000242796+19107_1460316.0RepeatNote=WD 3
HgeneWDR83chr19:12786455chr19:12786734ENST00000242796+19151_1880316.0RepeatNote=WD 4
HgeneWDR83chr19:12786455chr19:12786734ENST00000242796+19190_2280316.0RepeatNote=WD 5
HgeneWDR83chr19:12786455chr19:12786734ENST00000242796+19231_2720316.0RepeatNote=WD 6
HgeneWDR83chr19:12786455chr19:12786734ENST00000242796+1923_620316.0RepeatNote=WD 1
HgeneWDR83chr19:12786455chr19:12786734ENST00000242796+19275_3130316.0RepeatNote=WD 7
HgeneWDR83chr19:12786455chr19:12786734ENST00000242796+1965_1040316.0RepeatNote=WD 2
HgeneWDR83chr19:12786455chr19:12786734ENST00000418543+111107_1460316.0RepeatNote=WD 3
HgeneWDR83chr19:12786455chr19:12786734ENST00000418543+111151_1880316.0RepeatNote=WD 4
HgeneWDR83chr19:12786455chr19:12786734ENST00000418543+111190_2280316.0RepeatNote=WD 5
HgeneWDR83chr19:12786455chr19:12786734ENST00000418543+111231_2720316.0RepeatNote=WD 6
HgeneWDR83chr19:12786455chr19:12786734ENST00000418543+11123_620316.0RepeatNote=WD 1
HgeneWDR83chr19:12786455chr19:12786734ENST00000418543+111275_3130316.0RepeatNote=WD 7
HgeneWDR83chr19:12786455chr19:12786734ENST00000418543+11165_1040316.0RepeatNote=WD 2


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Fusion Gene Sequence for WDR83-DHPS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for WDR83-DHPS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WDR83-DHPS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WDR83-DHPS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource