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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WDR86-ZNF444 (FusionGDB2 ID:99129)

Fusion Gene Summary for WDR86-ZNF444

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR86-ZNF444
Fusion gene ID: 99129
HgeneTgene
Gene symbol

WDR86

ZNF444

Gene ID

349136

55311

Gene nameWD repeat domain 86zinc finger protein 444
Synonyms-EZF-2|EZF2|ZSCAN17
Cytomap

7q36.1

19q13.43

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 86zinc finger protein 444endothelial zinc finger protein 2zinc finger and SCAN domain-containing protein 17
Modification date2020031320200313
UniProtAcc.

Q8N0Y2

Ensembl transtripts involved in fusion geneENST00000334493, ENST00000469830, 
ENST00000477459, ENST00000463000, 
ENST00000592171, ENST00000337080, 
ENST00000592949, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WDR86 [Title/Abstract] AND ZNF444 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDR86(151092861)-ZNF444(56669862), # samples:1
Anticipated loss of major functional domain due to fusion event.WDR86-ZNF444 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WDR86-ZNF444 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across WDR86 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF444 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-EL-A3D6WDR86chr7

151092861

-ZNF444chr19

56669862

+


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Fusion Gene ORF analysis for WDR86-ZNF444

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000334493ENST00000592171WDR86chr7

151092861

-ZNF444chr19

56669862

+
5CDS-3UTRENST00000469830ENST00000592171WDR86chr7

151092861

-ZNF444chr19

56669862

+
5CDS-3UTRENST00000477459ENST00000592171WDR86chr7

151092861

-ZNF444chr19

56669862

+
5UTR-3CDSENST00000463000ENST00000337080WDR86chr7

151092861

-ZNF444chr19

56669862

+
5UTR-3CDSENST00000463000ENST00000592949WDR86chr7

151092861

-ZNF444chr19

56669862

+
5UTR-3UTRENST00000463000ENST00000592171WDR86chr7

151092861

-ZNF444chr19

56669862

+
Frame-shiftENST00000477459ENST00000337080WDR86chr7

151092861

-ZNF444chr19

56669862

+
Frame-shiftENST00000477459ENST00000592949WDR86chr7

151092861

-ZNF444chr19

56669862

+
In-frameENST00000334493ENST00000337080WDR86chr7

151092861

-ZNF444chr19

56669862

+
In-frameENST00000334493ENST00000592949WDR86chr7

151092861

-ZNF444chr19

56669862

+
In-frameENST00000469830ENST00000337080WDR86chr7

151092861

-ZNF444chr19

56669862

+
In-frameENST00000469830ENST00000592949WDR86chr7

151092861

-ZNF444chr19

56669862

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334493WDR86chr7151092861-ENST00000337080ZNF444chr1956669862+25351157861843585
ENST00000334493WDR86chr7151092861-ENST00000592949ZNF444chr1956669862+25331157861840584
ENST00000469830WDR86chr7151092861-ENST00000337080ZNF444chr1956669862+2146768421454470
ENST00000469830WDR86chr7151092861-ENST00000592949ZNF444chr1956669862+2144768421451469

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334493ENST00000337080WDR86chr7151092861-ZNF444chr1956669862+0.238334370.7616657
ENST00000334493ENST00000592949WDR86chr7151092861-ZNF444chr1956669862+0.242152420.75784755
ENST00000469830ENST00000337080WDR86chr7151092861-ZNF444chr1956669862+0.22662640.7733736
ENST00000469830ENST00000592949WDR86chr7151092861-ZNF444chr1956669862+0.232137220.7678628

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Fusion Genomic Features for WDR86-ZNF444


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WDR86chr7151092861-ZNF444chr1956669862+0.0001252190.9998747
WDR86chr7151092861-ZNF444chr1956669862+0.0001252190.9998747

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for WDR86-ZNF444


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:151092861/chr19:56669862)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ZNF444

Q8N0Y2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR86chr7:151092861chr19:56669862ENST00000334493-36135_188242377.0RepeatNote=WD 4
HgeneWDR86chr7:151092861chr19:56669862ENST00000334493-3613_52242377.0RepeatNote=WD 1
HgeneWDR86chr7:151092861chr19:56669862ENST00000334493-36191_232242377.0RepeatNote=WD 5
HgeneWDR86chr7:151092861chr19:56669862ENST00000334493-3655_94242377.0RepeatNote=WD 2
HgeneWDR86chr7:151092861chr19:56669862ENST00000334493-3695_132242377.0RepeatNote=WD 3
TgeneZNF444chr7:151092861chr19:56669862ENST0000033708025179_20199328.0Zinc fingerC2H2-type 1
TgeneZNF444chr7:151092861chr19:56669862ENST0000033708025207_22999328.0Zinc fingerC2H2-type 2
TgeneZNF444chr7:151092861chr19:56669862ENST0000033708025250_27299328.0Zinc fingerC2H2-type 3
TgeneZNF444chr7:151092861chr19:56669862ENST0000033708025278_30099328.0Zinc fingerC2H2-type 4
TgeneZNF444chr7:151092861chr19:56669862ENST0000059294925179_20199327.0Zinc fingerC2H2-type 1
TgeneZNF444chr7:151092861chr19:56669862ENST0000059294925207_22999327.0Zinc fingerC2H2-type 2
TgeneZNF444chr7:151092861chr19:56669862ENST0000059294925250_27299327.0Zinc fingerC2H2-type 3
TgeneZNF444chr7:151092861chr19:56669862ENST0000059294925278_30099327.0Zinc fingerC2H2-type 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR86chr7:151092861chr19:56669862ENST00000334493-36234_272242377.0RepeatNote=WD 6
HgeneWDR86chr7:151092861chr19:56669862ENST00000334493-36274_310242377.0RepeatNote=WD 7
HgeneWDR86chr7:151092861chr19:56669862ENST00000334493-36313_350242377.0RepeatNote=WD 8
TgeneZNF444chr7:151092861chr19:56669862ENST000003370802520_10499328.0DomainSCAN box
TgeneZNF444chr7:151092861chr19:56669862ENST000005929492520_10499327.0DomainSCAN box


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Fusion Gene Sequence for WDR86-ZNF444


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99129_99129_1_WDR86-ZNF444_WDR86_chr7_151092861_ENST00000334493_ZNF444_chr19_56669862_ENST00000337080_length(transcript)=2535nt_BP=1157nt
CGGCCGGGGAGGGCGCGGGGCGCTCGGCTTCCCGTGTTCCTCTCCCCGCCCCAGCCCCGTGGGCGCGAGAGGAGGCGGGGGGCTCCTTGT
GCACCAGAGACGCAGCTGCCTTGTTCGCCCGGTGGGGTGTGGATCCTCCGAGCGGTGCTGGGAAGGGGGTTCTCTCTGCCCGCGCGCCCA
GGACTCTACCCAGGGCGGAGGTCCCGAGTGGGCCGCCCCCCGCAGCGCCCTGGGTTCGCGGGCCCAGAGGCTGGAGGCAGCGGGGAGCTA
GGGTCCTTCACCCTCCCCTCGCCGCGTGCCTCCGCAGGAGTCGGGCTCCCCGTTCCCCGCGATGGCCGCGGGCCGCAGTCGTACGGAGCC
GCCGCGCGGACCCCGGGGCGCCCCTCCCTAGCGGGGCGCAGCTCCTTCTTGTTCCCCGCCCTGCCAGCGGGATGGGGGGCGGCGGGTCGG
CCCTGAGGGTCTGCGCCGACCACCGCGGGGGCATCAACTGGCTGAGCCTGAGCCCCGACGGGCAGCGCCTGCTGACGGGCAGCGAGGACG
GCACGGCCCGGCTCTGGAGCACCGCGGACGGCCAGTGCTGCGCGCTCCTGCAAGGACATGAAAGCTATGTGACCTTCTGCCAGCTGGAGG
ATGAGGCTGCCTTCACATGCAGCGCCGACTGCACCATCAGGAGGTGGGACGTGCTGACCGGGCAGTGTCTGCAGGTGTACCGAGGACACA
CGTCCATCGTGAACAGGATCCTGGTTGCCAACAACCAGCTCTTCAGCAGCTCCTATGACCGGACAGCTCGGGTCTGGAGTGTGGACAAGG
GGCAGATGTCCCGGGAGTTCCGGGGCCACCGCAACTGCGTGCTGACCCTAGCCTACTCTGCCCCGTGGGACCTCCCCAGCACTCCCTGCG
CGGAGGAGGCCGCGGCCGGGGGGCTTCTGGTGACCGGCAGCACAGATGGCACAGCCAAGGTGTGGCAGGTGGCCAGCGGCTGCTGCCACC
AGACGCTGCGGGGCCACACGGGTGCAGTGCTGTGCCTAGTGCTAGACACGCCCGGCCACACGGCCTTCACAGGCAGCACCGACGCCACCA
TCCGTGCCTGGGACATCCTGAGTGGGGAGCAGCTGCGGGTGTTCCGGGAGCACCGGGGCTCCGTCATCTGTCTGGAGGGGCCAGCAGCCT
CCCCCGATGGGTCGTCAGCAACGAGGGTGCCTCAGGATGTGACGCAGGGCCCTGGGGCCACAGGTGGAAAGGAGGACAGTGGGATGATTC
CCTTAGCAGGCACCGCCCCTGGGGCTGAGGGGCCGGCGCCTGGGGACTCCCAGGCTGTGCGCCCCTACAAGCAGGAGCCCAGCAGCCCCC
CGCTGGCGCCTGGCCTGCCCGCCTTCCTAGCGGCCCCGGGCACCACGTCCTGCCCCGAGTGCGGCAAAACGTCCCTGAAACCAGCTCACC
TGCTGCGCCACCGGCAGAGCCACTCGGGCGAGAAGCCGCACGCCTGCCCTGAGTGCGGGAAGGCCTTTCGGCGCAAGGAGCACCTGCGGC
GCCACCGCGACACGCACCCCGGCAGCCCCGGCAGCCCCGGGCCCGCGCTGCGCCCTCTGCCCGCCCGTGAGAAGCCCCACGCGTGCTGCG
AGTGTGGCAAGACCTTCTACTGGCGCGAGCACCTGGTGCGCCACCGCAAGACGCACTCGGGAGCGCGGCCCTTTGCCTGCTGGGAGTGTG
GCAAGGGCTTCGGGCGCCGCGAGCACGTGCTGCGCCACCAGCGCATCCACGGCCGGGCAGCGGCCAGCGCGCAGGGGGCGGTAGCTCCGG
GCCCGGATGGTGGAGGCCCCTTCCCGCCCTGGCCCTTGGGTTAGCCGCCTCCCGGCCAGCGCCATCTCCCGCCCTTGGTGCTGCCCCCGG
GCGGTACCTGCTCTCTCCCAGCGCCACTTGGCCTCTTCCTCTCCTCCTTCCCTCCCATCGTCCTCCTCCACCTGCGCCTCCCTTGTCTGA
ACTTCCCAACGCCTTCCTATTCCTTTCCAACTCCTTTTCCCCCAAATTTCACTTTCCTTCTCAGGTCTCACCTCAGCCCCCCCCTTCTCC
CTGATTTCTCGGCCTCTCTCTCTGTGTGAAGGGGCCTCTCCCTAATGTCTCCTCCTTCCCCCCTCTTCTCTCTCCTGCGGCCCAGCCTCC
CTCTCCCTCCTCCATTCCTCTCTCCCTGCCCTTTTCCTGCCTGAAGAGCAGAGGTGAGGACCTGGGACCCCTGAGGGGCAGGCCAGGAGG
AGCTCGGGCGCAGGCCAGGCCCCCTTGGTGAAGCAGAGGCTGAAGGAAAGGGGTCTGGGTCTTGTCCCTAGGAATTCTCCTCCCTCAGGA
GATTGGGGGTTGGGGGAGGCAGCGGGTGATGGCTCTGAAGCTGAACCCAGGGCCTGGCTGTGGTCTTCTTGGTCTTGCTGCCCCCTGTGA
CCCAAAGGCATGGGATGGACAGAGATGCCTGCCCCCGTGAAGCTGGTTGGGGAGGGCAGTTCACCAGCATCCATAGAGTAATAAAGTCAC

>99129_99129_1_WDR86-ZNF444_WDR86_chr7_151092861_ENST00000334493_ZNF444_chr19_56669862_ENST00000337080_length(amino acids)=585AA_BP=458
MCTRDAAALFARWGVDPPSGAGKGVLSARAPRTLPRAEVPSGPPPAAPWVRGPRGWRQRGARVLHPPLAACLRRSRAPRSPRWPRAAVVR
SRRADPGAPLPSGAQLLLVPRPASGMGGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL
EDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTP
CAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEGPA
ASPDGSSATRVPQDVTQGPGATGGKEDSGMIPLAGTAPGAEGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPA
HLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGSPGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWE

--------------------------------------------------------------
>99129_99129_2_WDR86-ZNF444_WDR86_chr7_151092861_ENST00000334493_ZNF444_chr19_56669862_ENST00000592949_length(transcript)=2533nt_BP=1157nt
CGGCCGGGGAGGGCGCGGGGCGCTCGGCTTCCCGTGTTCCTCTCCCCGCCCCAGCCCCGTGGGCGCGAGAGGAGGCGGGGGGCTCCTTGT
GCACCAGAGACGCAGCTGCCTTGTTCGCCCGGTGGGGTGTGGATCCTCCGAGCGGTGCTGGGAAGGGGGTTCTCTCTGCCCGCGCGCCCA
GGACTCTACCCAGGGCGGAGGTCCCGAGTGGGCCGCCCCCCGCAGCGCCCTGGGTTCGCGGGCCCAGAGGCTGGAGGCAGCGGGGAGCTA
GGGTCCTTCACCCTCCCCTCGCCGCGTGCCTCCGCAGGAGTCGGGCTCCCCGTTCCCCGCGATGGCCGCGGGCCGCAGTCGTACGGAGCC
GCCGCGCGGACCCCGGGGCGCCCCTCCCTAGCGGGGCGCAGCTCCTTCTTGTTCCCCGCCCTGCCAGCGGGATGGGGGGCGGCGGGTCGG
CCCTGAGGGTCTGCGCCGACCACCGCGGGGGCATCAACTGGCTGAGCCTGAGCCCCGACGGGCAGCGCCTGCTGACGGGCAGCGAGGACG
GCACGGCCCGGCTCTGGAGCACCGCGGACGGCCAGTGCTGCGCGCTCCTGCAAGGACATGAAAGCTATGTGACCTTCTGCCAGCTGGAGG
ATGAGGCTGCCTTCACATGCAGCGCCGACTGCACCATCAGGAGGTGGGACGTGCTGACCGGGCAGTGTCTGCAGGTGTACCGAGGACACA
CGTCCATCGTGAACAGGATCCTGGTTGCCAACAACCAGCTCTTCAGCAGCTCCTATGACCGGACAGCTCGGGTCTGGAGTGTGGACAAGG
GGCAGATGTCCCGGGAGTTCCGGGGCCACCGCAACTGCGTGCTGACCCTAGCCTACTCTGCCCCGTGGGACCTCCCCAGCACTCCCTGCG
CGGAGGAGGCCGCGGCCGGGGGGCTTCTGGTGACCGGCAGCACAGATGGCACAGCCAAGGTGTGGCAGGTGGCCAGCGGCTGCTGCCACC
AGACGCTGCGGGGCCACACGGGTGCAGTGCTGTGCCTAGTGCTAGACACGCCCGGCCACACGGCCTTCACAGGCAGCACCGACGCCACCA
TCCGTGCCTGGGACATCCTGAGTGGGGAGCAGCTGCGGGTGTTCCGGGAGCACCGGGGCTCCGTCATCTGTCTGGAGGGGCCAGCAGCCT
CCCCCGATGGGTCGTCAGCAACGAGGGTGCCTCAGGATGTGACGCAGGGCCCTGGGGCCACAGGTGGAAAGGAGGACAGTGGGATGATTC
CCTTAGGCACCGCCCCTGGGGCTGAGGGGCCGGCGCCTGGGGACTCCCAGGCTGTGCGCCCCTACAAGCAGGAGCCCAGCAGCCCCCCGC
TGGCGCCTGGCCTGCCCGCCTTCCTAGCGGCCCCGGGCACCACGTCCTGCCCCGAGTGCGGCAAAACGTCCCTGAAACCAGCTCACCTGC
TGCGCCACCGGCAGAGCCACTCGGGCGAGAAGCCGCACGCCTGCCCTGAGTGCGGGAAGGCCTTTCGGCGCAAGGAGCACCTGCGGCGCC
ACCGCGACACGCACCCCGGCAGCCCCGGCAGCCCCGGGCCCGCGCTGCGCCCTCTGCCCGCCCGTGAGAAGCCCCACGCGTGCTGCGAGT
GTGGCAAGACCTTCTACTGGCGCGAGCACCTGGTGCGCCACCGCAAGACGCACTCGGGAGCGCGGCCCTTTGCCTGCTGGGAGTGTGGCA
AGGGCTTCGGGCGCCGCGAGCACGTGCTGCGCCACCAGCGCATCCACGGCCGGGCAGCGGCCAGCGCGCAGGGGGCGGTAGCTCCGGGCC
CGGATGGTGGAGGCCCCTTCCCGCCCTGGCCCTTGGGTTAGCCGCCTCCCGGCCAGCGCCATCTCCCGCCCTTGGTGCTGCCCCCGGGCG
GTACCTGCTCTCTCCCAGCGCCACTTGGCCTCTTCCTCTCCTCCTTCCCTCCCATCGTCCTCCTCCACCTGCGCCTCCCTTGTCTGAACT
TCCCAACGCCTTCCTATTCCTTTCCAACTCCTTTTCCCCCAAATTTCACTTTCCTTCTCAGGTCTCACCTCAGCCCCCCCCTTCTCCCTG
ATTTCTCGGCCTCTCTCTCTGTGTGAAGGGGCCTCTCCCTAATGTCTCCTCCTTCCCCCCTCTTCTCTCTCCTGCGGCCCAGCCTCCCTC
TCCCTCCTCCATTCCTCTCTCCCTGCCCTTTTCCTGCCTGAAGAGCAGAGGTGAGGACCTGGGACCCCTGAGGGGCAGGCCAGGAGGAGC
TCGGGCGCAGGCCAGGCCCCCTTGGTGAAGCAGAGGCTGAAGGAAAGGGGTCTGGGTCTTGTCCCTAGGAATTCTCCTCCCTCAGGAGAT
TGGGGGTTGGGGGAGGCAGCGGGTGATGGCTCTGAAGCTGAACCCAGGGCCTGGCTGTGGTCTTCTTGGTCTTGCTGCCCCCTGTGACCC
AAAGGCATGGGATGGACAGAGATGCCTGCCCCCGTGAAGCTGGTTGGGGAGGGCAGTTCACCAGCATCCATAGAGTAATAAAGTCACTGT

>99129_99129_2_WDR86-ZNF444_WDR86_chr7_151092861_ENST00000334493_ZNF444_chr19_56669862_ENST00000592949_length(amino acids)=584AA_BP=457
MCTRDAAALFARWGVDPPSGAGKGVLSARAPRTLPRAEVPSGPPPAAPWVRGPRGWRQRGARVLHPPLAACLRRSRAPRSPRWPRAAVVR
SRRADPGAPLPSGAQLLLVPRPASGMGGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL
EDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTP
CAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEGPA
ASPDGSSATRVPQDVTQGPGATGGKEDSGMIPLGTAPGAEGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAH
LLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGSPGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWEC

--------------------------------------------------------------
>99129_99129_3_WDR86-ZNF444_WDR86_chr7_151092861_ENST00000469830_ZNF444_chr19_56669862_ENST00000337080_length(transcript)=2146nt_BP=768nt
AGCGGGGCGCAGCTCCTTCTTGTTCCCCGCCCTGCCAGCGGGATGGGGGGCGGCGGGTCGGCCCTGAGGGTCTGCGCCGACCACCGCGGG
GGCATCAACTGGCTGAGCCTGAGCCCCGACGGGCAGCGCCTGCTGACGGGCAGCGAGGACGGCACGGCCCGGCTCTGGAGCACCGCGGAC
GGCCAGTGCTGCGCGCTCCTGCAAGGACATGAAAGCTATGTGACCTTCTGCCAGCTGGAGGATGAGGCTGCCTTCACATGCAGCGCCGAC
TGCACCATCAGGAGGTGGGACGTGCTGACCGGGCAGTGTCTGCAGGTGTACCGAGGACACACGTCCATCGTGAACAGGATCCTGGTTGCC
AACAACCAGCTCTTCAGCAGCTCCTATGACCGGACAGCTCGGGTCTGGAGTGTGGACAAGGGGCAGATGTCCCGGGAGTTCCGGGGCCAC
CGCAACTGCGTGCTGACCCTAGCCTACTCTGCCCCGTGGGACCTCCCCAGCACTCCCTGCGCGGAGGAGGCCGCGGCCGGGGGGCTTCTG
GTGACCGGCAGCACAGATGGCACAGCCAAGGTGTGGCAGGTGGCCAGCGGCTGCTGCCACCAGACGCTGCGGGGCCACACGGGTGCAGTG
CTGTGCCTAGTGCTAGACACGCCCGGCCACACGGCCTTCACAGGCAGCACCGACGCCACCATCCGTGCCTGGGACATCCTGAGTGGGGAG
CAGCTGCGGGTGTTCCGGGAGCACCGGGGCTCCGTCATCTGTCTGGAGGGGCCAGCAGCCTCCCCCGATGGGTCGTCAGCAACGAGGGTG
CCTCAGGATGTGACGCAGGGCCCTGGGGCCACAGGTGGAAAGGAGGACAGTGGGATGATTCCCTTAGCAGGCACCGCCCCTGGGGCTGAG
GGGCCGGCGCCTGGGGACTCCCAGGCTGTGCGCCCCTACAAGCAGGAGCCCAGCAGCCCCCCGCTGGCGCCTGGCCTGCCCGCCTTCCTA
GCGGCCCCGGGCACCACGTCCTGCCCCGAGTGCGGCAAAACGTCCCTGAAACCAGCTCACCTGCTGCGCCACCGGCAGAGCCACTCGGGC
GAGAAGCCGCACGCCTGCCCTGAGTGCGGGAAGGCCTTTCGGCGCAAGGAGCACCTGCGGCGCCACCGCGACACGCACCCCGGCAGCCCC
GGCAGCCCCGGGCCCGCGCTGCGCCCTCTGCCCGCCCGTGAGAAGCCCCACGCGTGCTGCGAGTGTGGCAAGACCTTCTACTGGCGCGAG
CACCTGGTGCGCCACCGCAAGACGCACTCGGGAGCGCGGCCCTTTGCCTGCTGGGAGTGTGGCAAGGGCTTCGGGCGCCGCGAGCACGTG
CTGCGCCACCAGCGCATCCACGGCCGGGCAGCGGCCAGCGCGCAGGGGGCGGTAGCTCCGGGCCCGGATGGTGGAGGCCCCTTCCCGCCC
TGGCCCTTGGGTTAGCCGCCTCCCGGCCAGCGCCATCTCCCGCCCTTGGTGCTGCCCCCGGGCGGTACCTGCTCTCTCCCAGCGCCACTT
GGCCTCTTCCTCTCCTCCTTCCCTCCCATCGTCCTCCTCCACCTGCGCCTCCCTTGTCTGAACTTCCCAACGCCTTCCTATTCCTTTCCA
ACTCCTTTTCCCCCAAATTTCACTTTCCTTCTCAGGTCTCACCTCAGCCCCCCCCTTCTCCCTGATTTCTCGGCCTCTCTCTCTGTGTGA
AGGGGCCTCTCCCTAATGTCTCCTCCTTCCCCCCTCTTCTCTCTCCTGCGGCCCAGCCTCCCTCTCCCTCCTCCATTCCTCTCTCCCTGC
CCTTTTCCTGCCTGAAGAGCAGAGGTGAGGACCTGGGACCCCTGAGGGGCAGGCCAGGAGGAGCTCGGGCGCAGGCCAGGCCCCCTTGGT
GAAGCAGAGGCTGAAGGAAAGGGGTCTGGGTCTTGTCCCTAGGAATTCTCCTCCCTCAGGAGATTGGGGGTTGGGGGAGGCAGCGGGTGA
TGGCTCTGAAGCTGAACCCAGGGCCTGGCTGTGGTCTTCTTGGTCTTGCTGCCCCCTGTGACCCAAAGGCATGGGATGGACAGAGATGCC

>99129_99129_3_WDR86-ZNF444_WDR86_chr7_151092861_ENST00000469830_ZNF444_chr19_56669862_ENST00000337080_length(amino acids)=470AA_BP=343
MGGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCL
QVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV
ASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEGPAASPDGSSATRVPQDVTQGPGATGGK
EDSGMIPLAGTAPGAEGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFR
RKEHLRRHRDTHPGSPGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAASA

--------------------------------------------------------------
>99129_99129_4_WDR86-ZNF444_WDR86_chr7_151092861_ENST00000469830_ZNF444_chr19_56669862_ENST00000592949_length(transcript)=2144nt_BP=768nt
AGCGGGGCGCAGCTCCTTCTTGTTCCCCGCCCTGCCAGCGGGATGGGGGGCGGCGGGTCGGCCCTGAGGGTCTGCGCCGACCACCGCGGG
GGCATCAACTGGCTGAGCCTGAGCCCCGACGGGCAGCGCCTGCTGACGGGCAGCGAGGACGGCACGGCCCGGCTCTGGAGCACCGCGGAC
GGCCAGTGCTGCGCGCTCCTGCAAGGACATGAAAGCTATGTGACCTTCTGCCAGCTGGAGGATGAGGCTGCCTTCACATGCAGCGCCGAC
TGCACCATCAGGAGGTGGGACGTGCTGACCGGGCAGTGTCTGCAGGTGTACCGAGGACACACGTCCATCGTGAACAGGATCCTGGTTGCC
AACAACCAGCTCTTCAGCAGCTCCTATGACCGGACAGCTCGGGTCTGGAGTGTGGACAAGGGGCAGATGTCCCGGGAGTTCCGGGGCCAC
CGCAACTGCGTGCTGACCCTAGCCTACTCTGCCCCGTGGGACCTCCCCAGCACTCCCTGCGCGGAGGAGGCCGCGGCCGGGGGGCTTCTG
GTGACCGGCAGCACAGATGGCACAGCCAAGGTGTGGCAGGTGGCCAGCGGCTGCTGCCACCAGACGCTGCGGGGCCACACGGGTGCAGTG
CTGTGCCTAGTGCTAGACACGCCCGGCCACACGGCCTTCACAGGCAGCACCGACGCCACCATCCGTGCCTGGGACATCCTGAGTGGGGAG
CAGCTGCGGGTGTTCCGGGAGCACCGGGGCTCCGTCATCTGTCTGGAGGGGCCAGCAGCCTCCCCCGATGGGTCGTCAGCAACGAGGGTG
CCTCAGGATGTGACGCAGGGCCCTGGGGCCACAGGTGGAAAGGAGGACAGTGGGATGATTCCCTTAGGCACCGCCCCTGGGGCTGAGGGG
CCGGCGCCTGGGGACTCCCAGGCTGTGCGCCCCTACAAGCAGGAGCCCAGCAGCCCCCCGCTGGCGCCTGGCCTGCCCGCCTTCCTAGCG
GCCCCGGGCACCACGTCCTGCCCCGAGTGCGGCAAAACGTCCCTGAAACCAGCTCACCTGCTGCGCCACCGGCAGAGCCACTCGGGCGAG
AAGCCGCACGCCTGCCCTGAGTGCGGGAAGGCCTTTCGGCGCAAGGAGCACCTGCGGCGCCACCGCGACACGCACCCCGGCAGCCCCGGC
AGCCCCGGGCCCGCGCTGCGCCCTCTGCCCGCCCGTGAGAAGCCCCACGCGTGCTGCGAGTGTGGCAAGACCTTCTACTGGCGCGAGCAC
CTGGTGCGCCACCGCAAGACGCACTCGGGAGCGCGGCCCTTTGCCTGCTGGGAGTGTGGCAAGGGCTTCGGGCGCCGCGAGCACGTGCTG
CGCCACCAGCGCATCCACGGCCGGGCAGCGGCCAGCGCGCAGGGGGCGGTAGCTCCGGGCCCGGATGGTGGAGGCCCCTTCCCGCCCTGG
CCCTTGGGTTAGCCGCCTCCCGGCCAGCGCCATCTCCCGCCCTTGGTGCTGCCCCCGGGCGGTACCTGCTCTCTCCCAGCGCCACTTGGC
CTCTTCCTCTCCTCCTTCCCTCCCATCGTCCTCCTCCACCTGCGCCTCCCTTGTCTGAACTTCCCAACGCCTTCCTATTCCTTTCCAACT
CCTTTTCCCCCAAATTTCACTTTCCTTCTCAGGTCTCACCTCAGCCCCCCCCTTCTCCCTGATTTCTCGGCCTCTCTCTCTGTGTGAAGG
GGCCTCTCCCTAATGTCTCCTCCTTCCCCCCTCTTCTCTCTCCTGCGGCCCAGCCTCCCTCTCCCTCCTCCATTCCTCTCTCCCTGCCCT
TTTCCTGCCTGAAGAGCAGAGGTGAGGACCTGGGACCCCTGAGGGGCAGGCCAGGAGGAGCTCGGGCGCAGGCCAGGCCCCCTTGGTGAA
GCAGAGGCTGAAGGAAAGGGGTCTGGGTCTTGTCCCTAGGAATTCTCCTCCCTCAGGAGATTGGGGGTTGGGGGAGGCAGCGGGTGATGG
CTCTGAAGCTGAACCCAGGGCCTGGCTGTGGTCTTCTTGGTCTTGCTGCCCCCTGTGACCCAAAGGCATGGGATGGACAGAGATGCCTGC

>99129_99129_4_WDR86-ZNF444_WDR86_chr7_151092861_ENST00000469830_ZNF444_chr19_56669862_ENST00000592949_length(amino acids)=469AA_BP=342
MGGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCL
QVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQV
ASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEGPAASPDGSSATRVPQDVTQGPGATGGK
EDSGMIPLGTAPGAEGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRR
KEHLRRHRDTHPGSPGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAASAQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WDR86-ZNF444


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WDR86-ZNF444


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WDR86-ZNF444


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource