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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WDSUB1-FYTTD1 (FusionGDB2 ID:99143)

Fusion Gene Summary for WDSUB1-FYTTD1

check button Fusion gene summary
Fusion gene informationFusion gene name: WDSUB1-FYTTD1
Fusion gene ID: 99143
HgeneTgene
Gene symbol

WDSUB1

FYTTD1

Gene ID

151525

84248

Gene nameWD repeat, sterile alpha motif and U-box domain containing 1forty-two-three domain containing 1
SynonymsUBOX6|WDSAM1UIF
Cytomap

2q24.2

3q29

Type of geneprotein-codingprotein-coding
DescriptionWD repeat, SAM and U-box domain-containing protein 1UAP56-interacting factorforty-two-three domain-containing protein 1protein 40-2-3
Modification date2020031320200313
UniProtAcc.

Q96QD9

Ensembl transtripts involved in fusion geneENST00000358147, ENST00000359774, 
ENST00000392796, ENST00000409124, 
ENST00000409990, 		ENST00000241502, 
ENST00000424384, ENST00000428395, 
ENST00000492360, ENST00000415708, 
Fusion gene scores* DoF score4 X 5 X 5=10010 X 10 X 6=600
# samples 511
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/600*10)=-2.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDSUB1 [Title/Abstract] AND FYTTD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDSUB1(160132057)-FYTTD1(197483297), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across WDSUB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FYTTD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IE-A3OV-01AWDSUB1chr2

160132057

-FYTTD1chr3

197483297

+


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Fusion Gene ORF analysis for WDSUB1-FYTTD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000358147ENST00000241502WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000358147ENST00000424384WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000358147ENST00000428395WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000359774ENST00000241502WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000359774ENST00000424384WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000359774ENST00000428395WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000392796ENST00000241502WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000392796ENST00000424384WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000392796ENST00000428395WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000409124ENST00000241502WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000409124ENST00000424384WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000409124ENST00000428395WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000409990ENST00000241502WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000409990ENST00000424384WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-5UTRENST00000409990ENST00000428395WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-intronENST00000358147ENST00000492360WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-intronENST00000359774ENST00000492360WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-intronENST00000392796ENST00000492360WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-intronENST00000409124ENST00000492360WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
5CDS-intronENST00000409990ENST00000492360WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
Frame-shiftENST00000392796ENST00000415708WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
Frame-shiftENST00000409990ENST00000415708WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
In-frameENST00000358147ENST00000415708WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
In-frameENST00000359774ENST00000415708WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+
In-frameENST00000409124ENST00000415708WDSUB1chr2

160132057

-FYTTD1chr3

197483297

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359774WDSUB1chr2160132057-ENST00000415708FYTTD1chr3197483297+1996917191770583
ENST00000358147WDSUB1chr2160132057-ENST00000415708FYTTD1chr3197483297+19008211151674519
ENST00000409124WDSUB1chr2160132057-ENST00000415708FYTTD1chr3197483297+1866787811640519

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359774ENST00000415708WDSUB1chr2160132057-FYTTD1chr3197483297+0.0035139970.99648607
ENST00000358147ENST00000415708WDSUB1chr2160132057-FYTTD1chr3197483297+0.0048761880.9951238
ENST00000409124ENST00000415708WDSUB1chr2160132057-FYTTD1chr3197483297+0.0051167720.9948833

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Fusion Genomic Features for WDSUB1-FYTTD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WDSUB1chr2160132056-FYTTD1chr3197483296+0.0001960930.99980396
WDSUB1chr2160132056-FYTTD1chr3197483296+0.0001960930.99980396

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for WDSUB1-FYTTD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:160132057/chr3:197483297)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FYTTD1

Q96QD9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269|PubMed:19836239}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000358147-4710_47225385.0RepeatNote=WD 1
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000358147-47137_176225385.0RepeatNote=WD 4
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000358147-47178_228225385.0RepeatNote=WD 5
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000358147-4752_91225385.0RepeatNote=WD 2
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000358147-4795_134225385.0RepeatNote=WD 3
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000359774-41110_47225477.0RepeatNote=WD 1
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000359774-411137_176225477.0RepeatNote=WD 4
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000359774-411178_228225477.0RepeatNote=WD 5
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000359774-41152_91225477.0RepeatNote=WD 2
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000359774-41195_134225477.0RepeatNote=WD 3
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000392796-41110_47225477.0RepeatNote=WD 1
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000392796-411137_176225477.0RepeatNote=WD 4
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000392796-411178_228225477.0RepeatNote=WD 5
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000392796-41152_91225477.0RepeatNote=WD 2
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000392796-41195_134225477.0RepeatNote=WD 3
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000409990-41110_47225477.0RepeatNote=WD 1
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000409990-411137_176225477.0RepeatNote=WD 4
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000409990-411178_228225477.0RepeatNote=WD 5
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000409990-41152_91225477.0RepeatNote=WD 2
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000409990-41195_134225477.0RepeatNote=WD 3
TgeneFYTTD1chr2:160132057chr3:197483297ENST0000041570811026_448293.0MotifNote=UAP56-binding motif
TgeneFYTTD1chr2:160132057chr3:197483297ENST000004243840926_440252.0MotifNote=UAP56-binding motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000358147-47332_396225385.0DomainSAM
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000358147-47403_476225385.0DomainNote=U-box
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000359774-411332_396225477.0DomainSAM
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000359774-411403_476225477.0DomainNote=U-box
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000392796-411332_396225477.0DomainSAM
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000392796-411403_476225477.0DomainNote=U-box
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000409990-411332_396225477.0DomainSAM
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000409990-411403_476225477.0DomainNote=U-box
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000358147-47237_276225385.0RepeatNote=WD 6
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000358147-47279_318225385.0RepeatNote=WD 7
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000359774-411237_276225477.0RepeatNote=WD 6
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000359774-411279_318225477.0RepeatNote=WD 7
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000392796-411237_276225477.0RepeatNote=WD 6
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000392796-411279_318225477.0RepeatNote=WD 7
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000409990-411237_276225477.0RepeatNote=WD 6
HgeneWDSUB1chr2:160132057chr3:197483297ENST00000409990-411279_318225477.0RepeatNote=WD 7
TgeneFYTTD1chr2:160132057chr3:197483297ENST000002415020926_4434319.0MotifNote=UAP56-binding motif


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Fusion Gene Sequence for WDSUB1-FYTTD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99143_99143_1_WDSUB1-FYTTD1_WDSUB1_chr2_160132057_ENST00000358147_FYTTD1_chr3_197483297_ENST00000415708_length(transcript)=1900nt_BP=821nt
CTGTTCCCTCTGCTCTGGGTCTCCGCCGGCGCCCGCCCCGCCAGCCTCACCTGCGCGGCACGTGACCCGCACCGCCCGTGGGCACCTTGA
AGGCGGATCCCGCGCGCCCCCGCTCCTGCAGGCTGTTTTTCTTCAAATAAAGAACATGGTGAAACTGATTCACACATTAGCTGATCATGG
TGACGATGTCAACTGCTGTGCCTTCTCCTTTTCCCTCTTGGCTACTTGCTCCTTGGACAAAACAATTCGCCTGTACTCGTTACGTGACTT
TACTGAACTGCCACATTCTCCATTGAAGTTTCATACCTATGCTGTCCACTGCTGCTGTTTCTCCCCTTCAGGACATATTTTGGCATCGTG
TTCAACAGATGGTACCACTGTCCTATGGAATACTGAAAATGGACAGATGCTGGCAGTGATGGAACAGCCTAGTGGCAGCCCTGTGAGGGT
TTGCCAGTTTTCCCCAGACTCCACGTGTTTGGCATCAGGGGCAGCTGATGGAACTGTGGTTTTGTGGAATGCACAGTCATACAAATTATA
TAGATGTGGTAGTGTTAAAGATGGCTCCTTGGCGGCATGTGCATTTTCTCCTAATGGAAGCTTCTTTGTCACTGGCTCCTCATGTGGTGA
TTTAACAGTGTGGGATGATAAAATGAGGTGTCCGCATAGTGAAAAAGCACATGATCTTGGAATTACCTGCTGCGATTTTTCTTCACAGCC
AGTTTCTGATGGAGAACAAGGTCTTCAGTTTTTTCGACTGGCATCATGTGGTCAGGATTGCCAAGTCAAAATTTGGATTGTTTCTTTTAC
CCATATCTTAGATGATATCATCAAGTTGAATCGAAAGGAAGGGAAGAAGCAGAATTTTCCAAGACTAAATAGAAGACTCCTCCAGCAAAG
TGGTGCCCAGCAATTCAGGATGAGAGTGCGATGGGGAATCCAACAGAATTCTGGTTTTGGTAAGACTAGTCTGAATCGTAGAGGAAGAGT
AATGCCTGGAAAGAGACGTCCTAATGGAGTTATCACTGGCCTTGCAGCTAGGAAAACGACTGGAATTCGAAAAGGAATTAGTCCTATGAA
TCGTCCACCTCTAAGTGACAAGAATATAGAACAATATTTTCCAGTGTTAAAAAGGAAGGCAAACCTTCTGAGACAAAATGAAGGGCAGAG
GAAACCAGTAGCAGTTCTCAAGAGACCTAGCCAGCTAAGCAGAAAAAATAACATTCCAGCTAATTTTACCAGGAGTGGAAATAAATTAAA
TCATCAGAAAGATACTCGTCAGGCAACTTTTCTTTTCAGAAGAGGCCTGAAGGTGCAGGCCCAGTTGAATACAGAACAACTGCTAGACGA
TGTAGTAGCAAAGAGAACTCGTCAATGGCGGACTTCCACCACAAATGGAGGGATTTTGACTGTATCTATTGACAATCCTGGAGCAGTGCA
ATGCCCAGTAACTCAGAAACCACGATTAACTCGTACTGCTGTACCTTCATTTTTAACAAAGCGGGAGCAAAGTGACGTCAAGAAAGTTCC
TAAAGGTGTTCCCCTGCAGTTTGACATAAACAGTGTCGGAAAACAGACAGGGATGACGTTGAATGAGCGGTTTGGGATCCTGAAGGAACA
AAGAGCCACTCTCACATACAACAAAGGGGGAAGCCGCTTTGTCACCGTGGGATAGGTCCCATGTCAAAGGAACTTTTGAGTGATGACTCT
GAGAAGTTGAATTGCTTGAAGAGTTCATCACGGAAATTCAAGAAACTTTACTTCAAAATATTCACAAGGCTAAATAACTCTTATTTTTAT
TTTTGAAGGTTTTTTTTTTTAAAAAAAAAAACGTATAAAATAATGCCCTGAAAGAATAATAGGGATTATACCTGTCTGTTCTTAAAGATT

>99143_99143_1_WDSUB1-FYTTD1_WDSUB1_chr2_160132057_ENST00000358147_FYTTD1_chr3_197483297_ENST00000415708_length(amino acids)=519AA_BP=233
MQAVFLQIKNMVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVL
WNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM
RCPHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMR
VRWGIQQNSGFGKTSLNRRGRVMPGKRRPNGVITGLAARKTTGIRKGISPMNRPPLSDKNIEQYFPVLKRKANLLRQNEGQRKPVAVLKR
PSQLSRKNNIPANFTRSGNKLNHQKDTRQATFLFRRGLKVQAQLNTEQLLDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPVTQKPR

--------------------------------------------------------------
>99143_99143_2_WDSUB1-FYTTD1_WDSUB1_chr2_160132057_ENST00000359774_FYTTD1_chr3_197483297_ENST00000415708_length(transcript)=1996nt_BP=917nt
GGGGCCTACTCCCTCCGCTCTGGGTCACAGCGGGCGTTCGGGGGGCGGGGCCTGTTCCCTCCGCTCTGGGTCCCCGCGGGCGTTCGGGGG
CGGGGCCTGTTCCCTCTGCTCTGGGTCTCCGCCGGCGCCCGCCCCGCCAGCCTCACCTGCGCGGCACGTGACCCGCACCGCCCGTGGGCA
CCTTGAAGGCGGATCCCGCGCGCCCCCGCTCCTGCAGGCTGTTTTTCTTCAAATAAAGAACATGGTGAAACTGATTCACACATTAGCTGA
TCATGGTGACGATGTCAACTGCTGTGCCTTCTCCTTTTCCCTCTTGGCTACTTGCTCCTTGGACAAAACAATTCGCCTGTACTCGTTACG
TGACTTTACTGAACTGCCACATTCTCCATTGAAGTTTCATACCTATGCTGTCCACTGCTGCTGTTTCTCCCCTTCAGGACATATTTTGGC
ATCGTGTTCAACAGATGGTACCACTGTCCTATGGAATACTGAAAATGGACAGATGCTGGCAGTGATGGAACAGCCTAGTGGCAGCCCTGT
GAGGGTTTGCCAGTTTTCCCCAGACTCCACGTGTTTGGCATCAGGGGCAGCTGATGGAACTGTGGTTTTGTGGAATGCACAGTCATACAA
ATTATATAGATGTGGTAGTGTTAAAGATGGCTCCTTGGCGGCATGTGCATTTTCTCCTAATGGAAGCTTCTTTGTCACTGGCTCCTCATG
TGGTGATTTAACAGTGTGGGATGATAAAATGAGGTGTCCGCATAGTGAAAAAGCACATGATCTTGGAATTACCTGCTGCGATTTTTCTTC
ACAGCCAGTTTCTGATGGAGAACAAGGTCTTCAGTTTTTTCGACTGGCATCATGTGGTCAGGATTGCCAAGTCAAAATTTGGATTGTTTC
TTTTACCCATATCTTAGATGATATCATCAAGTTGAATCGAAAGGAAGGGAAGAAGCAGAATTTTCCAAGACTAAATAGAAGACTCCTCCA
GCAAAGTGGTGCCCAGCAATTCAGGATGAGAGTGCGATGGGGAATCCAACAGAATTCTGGTTTTGGTAAGACTAGTCTGAATCGTAGAGG
AAGAGTAATGCCTGGAAAGAGACGTCCTAATGGAGTTATCACTGGCCTTGCAGCTAGGAAAACGACTGGAATTCGAAAAGGAATTAGTCC
TATGAATCGTCCACCTCTAAGTGACAAGAATATAGAACAATATTTTCCAGTGTTAAAAAGGAAGGCAAACCTTCTGAGACAAAATGAAGG
GCAGAGGAAACCAGTAGCAGTTCTCAAGAGACCTAGCCAGCTAAGCAGAAAAAATAACATTCCAGCTAATTTTACCAGGAGTGGAAATAA
ATTAAATCATCAGAAAGATACTCGTCAGGCAACTTTTCTTTTCAGAAGAGGCCTGAAGGTGCAGGCCCAGTTGAATACAGAACAACTGCT
AGACGATGTAGTAGCAAAGAGAACTCGTCAATGGCGGACTTCCACCACAAATGGAGGGATTTTGACTGTATCTATTGACAATCCTGGAGC
AGTGCAATGCCCAGTAACTCAGAAACCACGATTAACTCGTACTGCTGTACCTTCATTTTTAACAAAGCGGGAGCAAAGTGACGTCAAGAA
AGTTCCTAAAGGTGTTCCCCTGCAGTTTGACATAAACAGTGTCGGAAAACAGACAGGGATGACGTTGAATGAGCGGTTTGGGATCCTGAA
GGAACAAAGAGCCACTCTCACATACAACAAAGGGGGAAGCCGCTTTGTCACCGTGGGATAGGTCCCATGTCAAAGGAACTTTTGAGTGAT
GACTCTGAGAAGTTGAATTGCTTGAAGAGTTCATCACGGAAATTCAAGAAACTTTACTTCAAAATATTCACAAGGCTAAATAACTCTTAT
TTTTATTTTTGAAGGTTTTTTTTTTTAAAAAAAAAAACGTATAAAATAATGCCCTGAAAGAATAATAGGGATTATACCTGTCTGTTCTTA

>99143_99143_2_WDSUB1-FYTTD1_WDSUB1_chr2_160132057_ENST00000359774_FYTTD1_chr3_197483297_ENST00000415708_length(amino acids)=583AA_BP=297
MGHSGRSGGGACSLRSGSPRAFGGGACSLCSGSPPAPAPPASPARHVTRTARGHLEGGSRAPPLLQAVFLQIKNMVKLIHTLADHGDDVN
CCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFS
PDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCPHSEKAHDLGITCCDFSSQPVSDG
EQGLQFFRLASCGQDCQVKIWIVSFTHILDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSGFGKTSLNRRGRVMPGK
RRPNGVITGLAARKTTGIRKGISPMNRPPLSDKNIEQYFPVLKRKANLLRQNEGQRKPVAVLKRPSQLSRKNNIPANFTRSGNKLNHQKD
TRQATFLFRRGLKVQAQLNTEQLLDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPVTQKPRLTRTAVPSFLTKREQSDVKKVPKGVP

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>99143_99143_3_WDSUB1-FYTTD1_WDSUB1_chr2_160132057_ENST00000409124_FYTTD1_chr3_197483297_ENST00000415708_length(transcript)=1866nt_BP=787nt
GCCCCGCCAGCCTCACCTGCGCGGCACGTGACCCGCACCGCCCGTGGGCACCTTGAAGGCGGATCCCGCGCGCCCCCGCTCCTGCAGGCT
GTTTTTCTTCAAATAAAGAACATGGTGAAACTGATTCACACATTAGCTGATCATGGTGACGATGTCAACTGCTGTGCCTTCTCCTTTTCC
CTCTTGGCTACTTGCTCCTTGGACAAAACAATTCGCCTGTACTCGTTACGTGACTTTACTGAACTGCCACATTCTCCATTGAAGTTTCAT
ACCTATGCTGTCCACTGCTGCTGTTTCTCCCCTTCAGGACATATTTTGGCATCGTGTTCAACAGATGGTACCACTGTCCTATGGAATACT
GAAAATGGACAGATGCTGGCAGTGATGGAACAGCCTAGTGGCAGCCCTGTGAGGGTTTGCCAGTTTTCCCCAGACTCCACGTGTTTGGCA
TCAGGGGCAGCTGATGGAACTGTGGTTTTGTGGAATGCACAGTCATACAAATTATATAGATGTGGTAGTGTTAAAGATGGCTCCTTGGCG
GCATGTGCATTTTCTCCTAATGGAAGCTTCTTTGTCACTGGCTCCTCATGTGGTGATTTAACAGTGTGGGATGATAAAATGAGGTGTCCG
CATAGTGAAAAAGCACATGATCTTGGAATTACCTGCTGCGATTTTTCTTCACAGCCAGTTTCTGATGGAGAACAAGGTCTTCAGTTTTTT
CGACTGGCATCATGTGGTCAGGATTGCCAAGTCAAAATTTGGATTGTTTCTTTTACCCATATCTTAGATGATATCATCAAGTTGAATCGA
AAGGAAGGGAAGAAGCAGAATTTTCCAAGACTAAATAGAAGACTCCTCCAGCAAAGTGGTGCCCAGCAATTCAGGATGAGAGTGCGATGG
GGAATCCAACAGAATTCTGGTTTTGGTAAGACTAGTCTGAATCGTAGAGGAAGAGTAATGCCTGGAAAGAGACGTCCTAATGGAGTTATC
ACTGGCCTTGCAGCTAGGAAAACGACTGGAATTCGAAAAGGAATTAGTCCTATGAATCGTCCACCTCTAAGTGACAAGAATATAGAACAA
TATTTTCCAGTGTTAAAAAGGAAGGCAAACCTTCTGAGACAAAATGAAGGGCAGAGGAAACCAGTAGCAGTTCTCAAGAGACCTAGCCAG
CTAAGCAGAAAAAATAACATTCCAGCTAATTTTACCAGGAGTGGAAATAAATTAAATCATCAGAAAGATACTCGTCAGGCAACTTTTCTT
TTCAGAAGAGGCCTGAAGGTGCAGGCCCAGTTGAATACAGAACAACTGCTAGACGATGTAGTAGCAAAGAGAACTCGTCAATGGCGGACT
TCCACCACAAATGGAGGGATTTTGACTGTATCTATTGACAATCCTGGAGCAGTGCAATGCCCAGTAACTCAGAAACCACGATTAACTCGT
ACTGCTGTACCTTCATTTTTAACAAAGCGGGAGCAAAGTGACGTCAAGAAAGTTCCTAAAGGTGTTCCCCTGCAGTTTGACATAAACAGT
GTCGGAAAACAGACAGGGATGACGTTGAATGAGCGGTTTGGGATCCTGAAGGAACAAAGAGCCACTCTCACATACAACAAAGGGGGAAGC
CGCTTTGTCACCGTGGGATAGGTCCCATGTCAAAGGAACTTTTGAGTGATGACTCTGAGAAGTTGAATTGCTTGAAGAGTTCATCACGGA
AATTCAAGAAACTTTACTTCAAAATATTCACAAGGCTAAATAACTCTTATTTTTATTTTTGAAGGTTTTTTTTTTTAAAAAAAAAAACGT

>99143_99143_3_WDSUB1-FYTTD1_WDSUB1_chr2_160132057_ENST00000409124_FYTTD1_chr3_197483297_ENST00000415708_length(amino acids)=519AA_BP=233
MQAVFLQIKNMVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVL
WNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM
RCPHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMR
VRWGIQQNSGFGKTSLNRRGRVMPGKRRPNGVITGLAARKTTGIRKGISPMNRPPLSDKNIEQYFPVLKRKANLLRQNEGQRKPVAVLKR
PSQLSRKNNIPANFTRSGNKLNHQKDTRQATFLFRRGLKVQAQLNTEQLLDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPVTQKPR

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Fusion Gene PPI Analysis for WDSUB1-FYTTD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WDSUB1-FYTTD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WDSUB1-FYTTD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource