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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WHSC1-LETM1 (FusionGDB2 ID:99227)

Fusion Gene Summary for WHSC1-LETM1

check button Fusion gene summary
Fusion gene informationFusion gene name: WHSC1-LETM1
Fusion gene ID: 99227
HgeneTgene
Gene symbol

WHSC1

LETM1

Gene ID

7468

3954

Gene namenuclear receptor binding SET domain protein 2leucine zipper and EF-hand containing transmembrane protein 1
SynonymsKMT3F|KMT3G|MMSET|REIIBP|TRX5|WHS|WHSC1SLC55A1
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase NSD2IL5 promoter REII region-binding proteinWolf-Hirschhorn syndrome candidate 1multiple myeloma SET domain containing protein type IIInuclear SET domain-containing protein 2probable histone-lysine N-methyltransferamitochondrial proton/calcium exchanger proteinLETM1 and EF-hand domain-containing protein 1, mitochondrialMdm38 homologleucine zipper-EF-hand containing transmembrane protein 1
Modification date2020032920200328
UniProtAcc.

O95202

Ensembl transtripts involved in fusion geneENST00000382891, ENST00000382892, 
ENST00000382895, ENST00000398261, 
ENST00000420906, ENST00000436793, 
ENST00000503128, ENST00000508803, 
ENST00000514045, ENST00000382888, 
ENST00000482415, 		ENST00000512189, 
ENST00000302787, 
Fusion gene scores* DoF score22 X 18 X 13=51485 X 4 X 4=80
# samples 278
** MAII scorelog2(27/5148*10)=-4.25298074116987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/80*10)=0
Context

PubMed: WHSC1 [Title/Abstract] AND LETM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWHSC1(1906105)-LETM1(1850936), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLETM1

GO:0006851

mitochondrial calcium ion transmembrane transport

19797662

TgeneLETM1

GO:0051560

mitochondrial calcium ion homeostasis

19797662

TgeneLETM1

GO:0099093

calcium export from the mitochondrion

19797662


check buttonFusion gene breakpoints across WHSC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LETM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-68-A59IWHSC1chr4

1906105

+LETM1chr4

1850936

-


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Fusion Gene ORF analysis for WHSC1-LETM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000382891ENST00000512189WHSC1chr4

1906105

+LETM1chr4

1850936

-
5CDS-5UTRENST00000382892ENST00000512189WHSC1chr4

1906105

+LETM1chr4

1850936

-
5CDS-5UTRENST00000382895ENST00000512189WHSC1chr4

1906105

+LETM1chr4

1850936

-
5CDS-5UTRENST00000398261ENST00000512189WHSC1chr4

1906105

+LETM1chr4

1850936

-
5CDS-5UTRENST00000420906ENST00000512189WHSC1chr4

1906105

+LETM1chr4

1850936

-
5CDS-5UTRENST00000436793ENST00000512189WHSC1chr4

1906105

+LETM1chr4

1850936

-
5CDS-5UTRENST00000503128ENST00000512189WHSC1chr4

1906105

+LETM1chr4

1850936

-
5CDS-5UTRENST00000508803ENST00000512189WHSC1chr4

1906105

+LETM1chr4

1850936

-
5CDS-5UTRENST00000514045ENST00000512189WHSC1chr4

1906105

+LETM1chr4

1850936

-
In-frameENST00000382891ENST00000302787WHSC1chr4

1906105

+LETM1chr4

1850936

-
In-frameENST00000382892ENST00000302787WHSC1chr4

1906105

+LETM1chr4

1850936

-
In-frameENST00000382895ENST00000302787WHSC1chr4

1906105

+LETM1chr4

1850936

-
In-frameENST00000398261ENST00000302787WHSC1chr4

1906105

+LETM1chr4

1850936

-
In-frameENST00000420906ENST00000302787WHSC1chr4

1906105

+LETM1chr4

1850936

-
In-frameENST00000436793ENST00000302787WHSC1chr4

1906105

+LETM1chr4

1850936

-
In-frameENST00000503128ENST00000302787WHSC1chr4

1906105

+LETM1chr4

1850936

-
In-frameENST00000508803ENST00000302787WHSC1chr4

1906105

+LETM1chr4

1850936

-
In-frameENST00000514045ENST00000302787WHSC1chr4

1906105

+LETM1chr4

1850936

-
intron-3CDSENST00000382888ENST00000302787WHSC1chr4

1906105

+LETM1chr4

1850936

-
intron-3CDSENST00000482415ENST00000302787WHSC1chr4

1906105

+LETM1chr4

1850936

-
intron-5UTRENST00000382888ENST00000512189WHSC1chr4

1906105

+LETM1chr4

1850936

-
intron-5UTRENST00000482415ENST00000512189WHSC1chr4

1906105

+LETM1chr4

1850936

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for WHSC1-LETM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for WHSC1-LETM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:1906105/chr4:1850936)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LETM1

O95202

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248). {ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:19797662, ECO:0000269|PubMed:24898248}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLETM1chr4:1906105chr4:1850936ENST00000302787014676_68827740.0Calcium bindingOntology_term=ECO:0000255
TgeneLETM1chr4:1906105chr4:1850936ENST00000302787014115_13627740.0Coiled coilOntology_term=ECO:0000255
TgeneLETM1chr4:1906105chr4:1850936ENST00000302787014462_49027740.0Coiled coilOntology_term=ECO:0000255
TgeneLETM1chr4:1906105chr4:1850936ENST00000302787014537_62727740.0Coiled coilOntology_term=ECO:0000255
TgeneLETM1chr4:1906105chr4:1850936ENST00000302787014708_73927740.0Coiled coilOntology_term=ECO:0000255
TgeneLETM1chr4:1906105chr4:1850936ENST00000302787014252_53727740.0DomainLetm1 RBD
TgeneLETM1chr4:1906105chr4:1850936ENST00000302787014663_69827740.0DomainEF-hand
TgeneLETM1chr4:1906105chr4:1850936ENST00000302787014116_20827740.0Topological domainMitochondrial intermembrane
TgeneLETM1chr4:1906105chr4:1850936ENST00000302787014230_73927740.0Topological domainMitochondrial matrix
TgeneLETM1chr4:1906105chr4:1850936ENST00000302787014209_22927740.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382888+112453_5210714.0DNA bindingHMG box
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382891+322453_5212531366.0DNA bindingHMG box
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382892+423453_5212531366.0DNA bindingHMG box
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382895+524453_5212531366.0DNA bindingHMG box
HgeneWHSC1chr4:1906105chr4:1850936ENST00000398261+29453_521253648.0DNA bindingHMG box
HgeneWHSC1chr4:1906105chr4:1850936ENST00000420906+511453_521253630.0DNA bindingHMG box
HgeneWHSC1chr4:1906105chr4:1850936ENST00000436793+56453_521253274.0DNA bindingHMG box
HgeneWHSC1chr4:1906105chr4:1850936ENST00000503128+310453_521253648.0DNA bindingHMG box
HgeneWHSC1chr4:1906105chr4:1850936ENST00000508803+322453_5212531366.0DNA bindingHMG box
HgeneWHSC1chr4:1906105chr4:1850936ENST00000514045+39453_521253630.0DNA bindingHMG box
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382888+1121011_10610714.0DomainAWS
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382888+1121063_11800714.0DomainSET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382888+1121187_12030714.0DomainPost-SET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382888+112222_2860714.0DomainPWWP 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382888+112880_9420714.0DomainPWWP 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382891+3221011_10612531366.0DomainAWS
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382891+3221063_11802531366.0DomainSET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382891+3221187_12032531366.0DomainPost-SET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382891+322222_2862531366.0DomainPWWP 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382891+322880_9422531366.0DomainPWWP 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382892+4231011_10612531366.0DomainAWS
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382892+4231063_11802531366.0DomainSET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382892+4231187_12032531366.0DomainPost-SET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382892+423222_2862531366.0DomainPWWP 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382892+423880_9422531366.0DomainPWWP 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382895+5241011_10612531366.0DomainAWS
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382895+5241063_11802531366.0DomainSET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382895+5241187_12032531366.0DomainPost-SET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382895+524222_2862531366.0DomainPWWP 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382895+524880_9422531366.0DomainPWWP 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000398261+291011_1061253648.0DomainAWS
HgeneWHSC1chr4:1906105chr4:1850936ENST00000398261+291063_1180253648.0DomainSET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000398261+291187_1203253648.0DomainPost-SET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000398261+29222_286253648.0DomainPWWP 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000398261+29880_942253648.0DomainPWWP 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000420906+5111011_1061253630.0DomainAWS
HgeneWHSC1chr4:1906105chr4:1850936ENST00000420906+5111063_1180253630.0DomainSET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000420906+5111187_1203253630.0DomainPost-SET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000420906+511222_286253630.0DomainPWWP 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000420906+511880_942253630.0DomainPWWP 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000436793+561011_1061253274.0DomainAWS
HgeneWHSC1chr4:1906105chr4:1850936ENST00000436793+561063_1180253274.0DomainSET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000436793+561187_1203253274.0DomainPost-SET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000436793+56222_286253274.0DomainPWWP 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000436793+56880_942253274.0DomainPWWP 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000503128+3101011_1061253648.0DomainAWS
HgeneWHSC1chr4:1906105chr4:1850936ENST00000503128+3101063_1180253648.0DomainSET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000503128+3101187_1203253648.0DomainPost-SET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000503128+310222_286253648.0DomainPWWP 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000503128+310880_942253648.0DomainPWWP 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000508803+3221011_10612531366.0DomainAWS
HgeneWHSC1chr4:1906105chr4:1850936ENST00000508803+3221063_11802531366.0DomainSET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000508803+3221187_12032531366.0DomainPost-SET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000508803+322222_2862531366.0DomainPWWP 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000508803+322880_9422531366.0DomainPWWP 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000514045+391011_1061253630.0DomainAWS
HgeneWHSC1chr4:1906105chr4:1850936ENST00000514045+391063_1180253630.0DomainSET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000514045+391187_1203253630.0DomainPost-SET
HgeneWHSC1chr4:1906105chr4:1850936ENST00000514045+39222_286253630.0DomainPWWP 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000514045+39880_942253630.0DomainPWWP 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382888+1121115_11180714.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382888+1121141_11420714.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382891+3221115_11182531366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382891+3221141_11422531366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382892+4231115_11182531366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382892+4231141_11422531366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382895+5241115_11182531366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382895+5241141_11422531366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000398261+291115_1118253648.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000398261+291141_1142253648.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000420906+5111115_1118253630.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000420906+5111141_1142253630.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000436793+561115_1118253274.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000436793+561141_1142253274.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000503128+3101115_1118253648.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000503128+3101141_1142253648.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000508803+3221115_11182531366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000508803+3221141_11422531366.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000514045+391115_1118253630.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000514045+391141_1142253630.0RegionS-adenosyl-L-methionine binding
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382888+1121239_12860714.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382888+112667_7130714.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382888+112714_7700714.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382888+112831_8750714.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382891+3221239_12862531366.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382891+322667_7132531366.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382891+322714_7702531366.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382891+322831_8752531366.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382892+4231239_12862531366.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382892+423667_7132531366.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382892+423714_7702531366.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382892+423831_8752531366.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382895+5241239_12862531366.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382895+524667_7132531366.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382895+524714_7702531366.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000382895+524831_8752531366.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1906105chr4:1850936ENST00000398261+291239_1286253648.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1906105chr4:1850936ENST00000398261+29667_713253648.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000398261+29714_770253648.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000398261+29831_875253648.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1906105chr4:1850936ENST00000420906+5111239_1286253630.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1906105chr4:1850936ENST00000420906+511667_713253630.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000420906+511714_770253630.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000420906+511831_875253630.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1906105chr4:1850936ENST00000436793+561239_1286253274.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1906105chr4:1850936ENST00000436793+56667_713253274.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000436793+56714_770253274.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000436793+56831_875253274.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1906105chr4:1850936ENST00000503128+3101239_1286253648.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1906105chr4:1850936ENST00000503128+310667_713253648.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000503128+310714_770253648.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000503128+310831_875253648.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1906105chr4:1850936ENST00000508803+3221239_12862531366.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1906105chr4:1850936ENST00000508803+322667_7132531366.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000508803+322714_7702531366.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000508803+322831_8752531366.0Zinc fingerPHD-type 3
HgeneWHSC1chr4:1906105chr4:1850936ENST00000514045+391239_1286253630.0Zinc fingerPHD-type 4%3B atypical
HgeneWHSC1chr4:1906105chr4:1850936ENST00000514045+39667_713253630.0Zinc fingerPHD-type 1
HgeneWHSC1chr4:1906105chr4:1850936ENST00000514045+39714_770253630.0Zinc fingerPHD-type 2
HgeneWHSC1chr4:1906105chr4:1850936ENST00000514045+39831_875253630.0Zinc fingerPHD-type 3
TgeneLETM1chr4:1906105chr4:1850936ENST0000030278701418_2127740.0Compositional biasNote=Poly-Pro


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Fusion Gene Sequence for WHSC1-LETM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for WHSC1-LETM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WHSC1-LETM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WHSC1-LETM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource