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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BMPR2-CYP20A1 (FusionGDB2 ID:9925)

Fusion Gene Summary for BMPR2-CYP20A1

Fusion gene summary

Fusion gene information	Fusion gene name: BMPR2-CYP20A1
	Fusion gene ID: 9925
		Hgene	Tgene
	Gene symbol	BMPR2	CYP20A1
	Gene ID	659	57404
	Gene name	bone morphogenetic protein receptor type 2	cytochrome P450 family 20 subfamily A member 1
	Synonyms	BMPR-II\|BMPR3\|BMR2\|BRK-3\|POVD1\|PPH1\|T-ALK	CYP-M
	Cytomap	2q33.1-q33.2	2q33.2
	Type of gene	protein-coding	protein-coding
	Description	bone morphogenetic protein receptor type-2BMP type II receptorBMP type-2 receptorbone morphogenetic protein receptor type IIbone morphogenetic protein receptor, type II (serine/threonine kinase)type II activin receptor-like kinasetype II receptor fo	cytochrome P450 20A1cytochrome P450 monooxygenasecytochrome P450, family 20, subfamily A, polypeptide 1
	Modification date	20200313	20200313
	UniProtAcc	Q13873	Q6UW02
	Ensembl transtripts involved in fusion gene	ENST00000479069, ENST00000374574, ENST00000374580,	ENST00000356079, ENST00000429815, ENST00000461371,
Fusion gene scores	* DoF score	20 X 12 X 9=2160	8 X 11 X 5=440
	# samples	21	9
	** MAII score	log2(21/2160*10)=-3.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/440*10)=-2.28950661719499 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BMPR2 [Title/Abstract] AND CYP20A1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BMPR2(203332412)-CYP20A1(204116690), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BMPR2	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	12045205
Hgene	BMPR2	GO:0010634	positive regulation of epithelial cell migration	12819188
Hgene	BMPR2	GO:0030308	negative regulation of cell growth	12819188
Hgene	BMPR2	GO:0030509	BMP signaling pathway	18436533

Fusion gene breakpoints across BMPR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CYP20A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E2-A573-01A	BMPR2	chr2	203332412	+	CYP20A1	chr2	204116690	+

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Fusion Gene ORF analysis for BMPR2-CYP20A1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000479069	ENST00000356079	BMPR2	chr2	203332412	+	CYP20A1	chr2	204116690	+
3UTR-3UTR	ENST00000479069	ENST00000429815	BMPR2	chr2	203332412	+	CYP20A1	chr2	204116690	+
3UTR-3UTR	ENST00000479069	ENST00000461371	BMPR2	chr2	203332412	+	CYP20A1	chr2	204116690	+
5CDS-3UTR	ENST00000374574	ENST00000429815	BMPR2	chr2	203332412	+	CYP20A1	chr2	204116690	+
5CDS-3UTR	ENST00000374574	ENST00000461371	BMPR2	chr2	203332412	+	CYP20A1	chr2	204116690	+
5CDS-3UTR	ENST00000374580	ENST00000429815	BMPR2	chr2	203332412	+	CYP20A1	chr2	204116690	+
5CDS-3UTR	ENST00000374580	ENST00000461371	BMPR2	chr2	203332412	+	CYP20A1	chr2	204116690	+
In-frame	ENST00000374574	ENST00000356079	BMPR2	chr2	203332412	+	CYP20A1	chr2	204116690	+
In-frame	ENST00000374580	ENST00000356079	BMPR2	chr2	203332412	+	CYP20A1	chr2	204116690	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000374580

BMPR2

chr2

203332412

ENST00000356079

CYP20A1

chr2

204116690

2494

957

524

2056

510

ENST00000374574

BMPR2

chr2

203332412

ENST00000356079

CYP20A1

chr2

204116690

1996

459

1558

510

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000374580	ENST00000356079	BMPR2	chr2	203332412	+	CYP20A1	chr2	204116690	+	0.001302225	0.99869776
ENST00000374574	ENST00000356079	BMPR2	chr2	203332412	+	CYP20A1	chr2	204116690	+	0.000653316	0.9993467

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Fusion Genomic Features for BMPR2-CYP20A1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
BMPR2	chr2	203332412	+	CYP20A1	chr2	204116689	+	5.73E-07	0.9999994
BMPR2	chr2	203332412	+	CYP20A1	chr2	204116689	+	5.73E-07	0.9999994

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BMPR2-CYP20A1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:203332412/chr2:204116690)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BMPR2 Q13873	CYP20A1 Q6UW02
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. {ECO:0000250\|UniProtKB:O35607}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BMPR2

chr2:203332412

chr2:204116690

ENST00000374580

547_550

139

1039.0

Compositional bias

Note=Poly-Ser

Hgene

BMPR2

chr2:203332412

chr2:204116690

ENST00000374580

610_618

139

1039.0

Compositional bias

Note=Poly-Thr

Hgene

BMPR2

chr2:203332412

chr2:204116690

ENST00000374580

901_908

139

1039.0

Compositional bias

Note=Poly-Asn

Hgene

BMPR2

chr2:203332412

chr2:204116690

ENST00000374580

203_504

139

1039.0

Domain

Protein kinase

Hgene

BMPR2

chr2:203332412

chr2:204116690

ENST00000374580

209_217

139

1039.0

Nucleotide binding

ATP

Hgene

BMPR2

chr2:203332412

chr2:204116690

ENST00000374580

280_282

139

1039.0

Nucleotide binding

ATP

Hgene

BMPR2

chr2:203332412

chr2:204116690

ENST00000374580

337_338

139

1039.0

Nucleotide binding

ATP

Hgene

BMPR2

chr2:203332412

chr2:204116690

ENST00000374580

172_1038

139

1039.0

Topological domain

Cytoplasmic

Hgene

BMPR2

chr2:203332412

chr2:204116690

ENST00000374580

27_150

139

1039.0

Topological domain

Extracellular

Hgene

BMPR2

chr2:203332412

chr2:204116690

ENST00000374580

151_171

139

1039.0

Transmembrane

Helical

Tgene

CYP20A1

chr2:203332412

chr2:204116690

ENST00000356079

4_24

463.0

Transmembrane

Helical

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Fusion Gene Sequence for BMPR2-CYP20A1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>9925_9925_1_BMPR2-CYP20A1_BMPR2_chr2_203332412_ENST00000374574_CYP20A1_chr2_204116690_ENST00000356079_length(transcript)=1996nt_BP=459nt
ATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGA
CCATCCTGCTGGTCAGCACTGCGGCTGCTTCGCAGAATCAAGAACGGCTATGTGCGTTTAAAGATCCGTATCAGCAAGACCTTGGGATAG
GTGAGAGTAGAATCTCTCATGAAAATGGGACAATATTATGCTCGAAAGGTAGCACCTGCTATGGCCTTTGGGAGAAATCAAAAGGGGACA
TAAATCTTGTAAAACAAGGATGTTGGTCTCACATTGGAGATCCCCAAGAGTGTCACTATGAAGAATGTGTAGTAACTACCACTCCTCCCT
CAATTCAGAATGGAACATACCGTTTCTGCTGTTGTAGCACAGATTTATGTAATGTCAACTTTACTGAGAATTTTCCACCTCCTGACACAA
CACCACTCACGGACCCTTTTGAAACCATGCTGAAGTCATTATTAAGGTATCAATCTGGTGGTGGCAGTGTGAGTGAAAACCACATGAGGA
AAAAATTGTATGAAAATGGTGTGACTGATTCTCTGAAGAGTAACTTTGCCCTCCTCCTAAAGCTTTCAGAAGAATTATTAGATAAATGGC
TCTCCTACCCAGAGACCCAGCACGTGCCCCTCAGCCAGCATATGCTTGGTTTTGCTATGAAGTCTGTTACACAGATGGTAATGGGTAGTA
CATTTGAAGATGATCAGGAAGTCATTCGCTTCCAGAAGAATCATGGCACAGTTTGGTCTGAGATTGGAAAAGGCTTTCTAGATGGGTCAC
TTGATAAAAACATGACTCGGAAAAAACAATATGAAGATGCCCTCATGCAACTGGAGTCTGTTTTAAGGAACATCATAAAAGAACGAAAAG
GAAGGAACTTCAGTCAACATATTTTCATTGACTCCTTAGTACAAGGGAACCTTAATGACCAACAGATCCTAGAAGACAGTATGATATTTT
CTCTGGCCAGTTGCATAATAACTGCAAAATTGTGTACCTGGGCAATCTGTTTTTTAACCACCTCTGAAGAAGTTCAAAAAAAATTATATG
AAGAGATAAACCAAGTTTTTGGAAATGGTCCTGTTACTCCAGAGAAAATTGAGCAGCTCAGATATTGTCAGCATGTGCTTTGTGAAACTG
TTCGAACTGCCAAACTGACTCCAGTTTCTGCCCAGCTTCAAGATATTGAAGGAAAAATTGACCGATTTATTATTCCTAGAGAGACCCTCG
TCCTTTATGCCCTTGGTGTGGTACTTCAGGATCCTAATACTTGGCCATCTCCACACAAGTTTGATCCAGATCGGTTTGATGATGAATTAG
TAATGAAAACTTTTTCCTCACTTGGATTCTCAGGCACACAGGAGTGTCCAGAGTTGAGGTTTGCATATATGGTGACCACAGTACTTCTTA
GTGTATTGGTGAAGAGACTGCACCTACTTTCTGTGGAGGGACAGGTTATTGAAACAAAGTATGAACTGGTAACATCATCAAGGGAAGAAG
CTTGGATCACTGTCTCAAAGAGATATTAAAATTTTATACATTTAAAATCATTGTTAAATTGATTGAGGAAAACAACCATTTAAAAAAAAT
CTATGTTGAATCCTTTTATAAACCAGTATCACTTTGTAATATAAACACCTATTTGTACTTAATTTTGTAAATTTGGATTTTTATATATCA
TATTTTCTTAATTCATTGTACACATTTGACTTACTGCACAGTATATTGATCATTTTAATGGGAAACTTTAGCTTTCTACTTTTTATTTTT
GTTTTTTCACTTTCTATGCCATTATTTTTGTATTCTTTTTCTTAGTGTGAGCTCTAAAATCAATGTTCTTGAAAAAGAAATTATTTTGCA
GAAGTTGGGGAATCATGTTTGTTGAATATGTATAAAATAGAAACATAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCTACACTTTGGG

>9925_9925_1_BMPR2-CYP20A1_BMPR2_chr2_203332412_ENST00000374574_CYP20A1_chr2_204116690_ENST00000356079_length(amino acids)=510AA_BP=145
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCW
SHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLTDPFETMLKSLLRYQSGGGSVSENHMRKKLYENGVT
DSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVMGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKK
QYEDALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN
GPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLG

--------------------------------------------------------------
>9925_9925_2_BMPR2-CYP20A1_BMPR2_chr2_203332412_ENST00000374580_CYP20A1_chr2_204116690_ENST00000356079_length(transcript)=2494nt_BP=957nt
GGAAGCACCGAAGCGAAACTTAAGGAATCCTGCCTTCCCGGAGCCGCGGGCGATGCGACTAGGGCTGCCGGGCGCCGCCGCCGCCCGTCC
GGCTTCGTCCTTCCCGGCAGTCGGGAACTAGTTCTGACCCTCGCCCCCCGACCCCGGATCGAATCCCCGCCCTCCGCACCCTGGATATGT
TTTCTCCCAGACCTGGATATTTTTTTGATATCGTGAAACTACGAGGGAAATAATTTGGGGGATTTCTTCTTGGCTCCCTGCTTTCCCCAC
AGACATGCCTTCCGTTTGGAGGGCCGCGGCACCCCGTCCGAGGCGAAGGAACCCCCCCAGCCGCGAGGGAGAGAAATGAAGGGAATTTCT
GCAGCGGCATGAAAGCTCTGCAGCTAGGTCCTCTCATCAGCCATTTGTCCTTTCAAACTGTATTGTGATACGGGCAGGATCAGTCCACGG
GAGAGAAGACGAGCCTCCCGGCTGTTTCTCCGCCGGTCTACTTCCCATATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGA
TGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGACCATCCTGCTGGTCAGCACTGCGGCTGCTTCGCAGAATCAAG
AACGGCTATGTGCGTTTAAAGATCCGTATCAGCAAGACCTTGGGATAGGTGAGAGTAGAATCTCTCATGAAAATGGGACAATATTATGCT
CGAAAGGTAGCACCTGCTATGGCCTTTGGGAGAAATCAAAAGGGGACATAAATCTTGTAAAACAAGGATGTTGGTCTCACATTGGAGATC
CCCAAGAGTGTCACTATGAAGAATGTGTAGTAACTACCACTCCTCCCTCAATTCAGAATGGAACATACCGTTTCTGCTGTTGTAGCACAG
ATTTATGTAATGTCAACTTTACTGAGAATTTTCCACCTCCTGACACAACACCACTCACGGACCCTTTTGAAACCATGCTGAAGTCATTAT
TAAGGTATCAATCTGGTGGTGGCAGTGTGAGTGAAAACCACATGAGGAAAAAATTGTATGAAAATGGTGTGACTGATTCTCTGAAGAGTA
ACTTTGCCCTCCTCCTAAAGCTTTCAGAAGAATTATTAGATAAATGGCTCTCCTACCCAGAGACCCAGCACGTGCCCCTCAGCCAGCATA
TGCTTGGTTTTGCTATGAAGTCTGTTACACAGATGGTAATGGGTAGTACATTTGAAGATGATCAGGAAGTCATTCGCTTCCAGAAGAATC
ATGGCACAGTTTGGTCTGAGATTGGAAAAGGCTTTCTAGATGGGTCACTTGATAAAAACATGACTCGGAAAAAACAATATGAAGATGCCC
TCATGCAACTGGAGTCTGTTTTAAGGAACATCATAAAAGAACGAAAAGGAAGGAACTTCAGTCAACATATTTTCATTGACTCCTTAGTAC
AAGGGAACCTTAATGACCAACAGATCCTAGAAGACAGTATGATATTTTCTCTGGCCAGTTGCATAATAACTGCAAAATTGTGTACCTGGG
CAATCTGTTTTTTAACCACCTCTGAAGAAGTTCAAAAAAAATTATATGAAGAGATAAACCAAGTTTTTGGAAATGGTCCTGTTACTCCAG
AGAAAATTGAGCAGCTCAGATATTGTCAGCATGTGCTTTGTGAAACTGTTCGAACTGCCAAACTGACTCCAGTTTCTGCCCAGCTTCAAG
ATATTGAAGGAAAAATTGACCGATTTATTATTCCTAGAGAGACCCTCGTCCTTTATGCCCTTGGTGTGGTACTTCAGGATCCTAATACTT
GGCCATCTCCACACAAGTTTGATCCAGATCGGTTTGATGATGAATTAGTAATGAAAACTTTTTCCTCACTTGGATTCTCAGGCACACAGG
AGTGTCCAGAGTTGAGGTTTGCATATATGGTGACCACAGTACTTCTTAGTGTATTGGTGAAGAGACTGCACCTACTTTCTGTGGAGGGAC
AGGTTATTGAAACAAAGTATGAACTGGTAACATCATCAAGGGAAGAAGCTTGGATCACTGTCTCAAAGAGATATTAAAATTTTATACATT
TAAAATCATTGTTAAATTGATTGAGGAAAACAACCATTTAAAAAAAATCTATGTTGAATCCTTTTATAAACCAGTATCACTTTGTAATAT
AAACACCTATTTGTACTTAATTTTGTAAATTTGGATTTTTATATATCATATTTTCTTAATTCATTGTACACATTTGACTTACTGCACAGT
ATATTGATCATTTTAATGGGAAACTTTAGCTTTCTACTTTTTATTTTTGTTTTTTCACTTTCTATGCCATTATTTTTGTATTCTTTTTCT
TAGTGTGAGCTCTAAAATCAATGTTCTTGAAAAAGAAATTATTTTGCAGAAGTTGGGGAATCATGTTTGTTGAATATGTATAAAATAGAA

>9925_9925_2_BMPR2-CYP20A1_BMPR2_chr2_203332412_ENST00000374580_CYP20A1_chr2_204116690_ENST00000356079_length(amino acids)=510AA_BP=145
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCW
SHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLTDPFETMLKSLLRYQSGGGSVSENHMRKKLYENGVT
DSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVMGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKK
QYEDALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN
GPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BMPR2-CYP20A1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for BMPR2-CYP20A1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for BMPR2-CYP20A1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source