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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:WNK1-DUSP16 (FusionGDB2 ID:99325) |
Fusion Gene Summary for WNK1-DUSP16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WNK1-DUSP16 | Fusion gene ID: 99325 | Hgene | Tgene | Gene symbol | WNK1 | DUSP16 | Gene ID | 65125 | 80824 |
| Gene name | WNK lysine deficient protein kinase 1 | dual specificity phosphatase 16 | |
| Synonyms | HSAN2|HSN2|KDP|PPP1R167|PRKWNK1|PSK|p65 | MKP-7|MKP7 | |
| Cytomap | 12p13.33 | 12p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase WNK1WNK lysine deficient protein kinase 1 isoformerythrocyte 65 kDa proteinprostate-derived sterile 20-like kinaseprotein kinase with no lysine 1protein phosphatase 1, regulatory subunit 167serine/threonine-protein ki | dual specificity protein phosphatase 16MAP kinase phosphatase 7MAPK phosphatase-7mitogen-activated protein kinase phosphatase 7 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | . | Q9BY84 | |
| Ensembl transtripts involved in fusion gene | ENST00000315939, ENST00000447667, ENST00000530271, ENST00000535572, ENST00000537687, ENST00000340908, ENST00000540360, ENST00000574564, | ENST00000545864, ENST00000298573, ENST00000228862, | |
| Fusion gene scores | * DoF score | 23 X 19 X 15=6555 | 8 X 5 X 6=240 |
| # samples | 37 | 7 | |
| ** MAII score | log2(37/6555*10)=-4.14699860459281 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/240*10)=-1.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: WNK1 [Title/Abstract] AND DUSP16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | WNK1(863490)-DUSP16(12640121), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | WNK1-DUSP16 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. WNK1-DUSP16 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. WNK1-DUSP16 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | WNK1 | GO:0006468 | protein phosphorylation | 10660600 |
| Hgene | WNK1 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Hgene | WNK1 | GO:0023016 | signal transduction by trans-phosphorylation | 16669787 |
| Hgene | WNK1 | GO:0035556 | intracellular signal transduction | 10660600 |
| Tgene | DUSP16 | GO:0016311 | dephosphorylation | 24531476 |
| Fusion gene breakpoints across WNK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DUSP16 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-98-A53I-01A | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
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Fusion Gene ORF analysis for WNK1-DUSP16 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000315939 | ENST00000545864 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| 5CDS-5UTR | ENST00000447667 | ENST00000545864 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| 5CDS-5UTR | ENST00000530271 | ENST00000545864 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| 5CDS-5UTR | ENST00000535572 | ENST00000545864 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| 5CDS-5UTR | ENST00000537687 | ENST00000545864 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| Frame-shift | ENST00000315939 | ENST00000298573 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| Frame-shift | ENST00000447667 | ENST00000298573 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| Frame-shift | ENST00000530271 | ENST00000298573 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| Frame-shift | ENST00000535572 | ENST00000298573 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| Frame-shift | ENST00000537687 | ENST00000298573 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| In-frame | ENST00000315939 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| In-frame | ENST00000447667 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| In-frame | ENST00000530271 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| In-frame | ENST00000535572 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| In-frame | ENST00000537687 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| intron-3CDS | ENST00000340908 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| intron-3CDS | ENST00000340908 | ENST00000298573 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| intron-3CDS | ENST00000540360 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| intron-3CDS | ENST00000540360 | ENST00000298573 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| intron-3CDS | ENST00000574564 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| intron-3CDS | ENST00000574564 | ENST00000298573 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| intron-5UTR | ENST00000340908 | ENST00000545864 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| intron-5UTR | ENST00000540360 | ENST00000545864 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| intron-5UTR | ENST00000574564 | ENST00000545864 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000535572 | WNK1 | chr12 | 863490 | - | ENST00000228862 | DUSP16 | chr12 | 12640121 | - | 4137 | 1732 | 826 | 3198 | 790 |
| ENST00000537687 | WNK1 | chr12 | 863490 | - | ENST00000228862 | DUSP16 | chr12 | 12640121 | - | 3807 | 1402 | 496 | 2868 | 790 |
| ENST00000315939 | WNK1 | chr12 | 863490 | - | ENST00000228862 | DUSP16 | chr12 | 12640121 | - | 3807 | 1402 | 496 | 2868 | 790 |
| ENST00000447667 | WNK1 | chr12 | 863490 | - | ENST00000228862 | DUSP16 | chr12 | 12640121 | - | 3674 | 1269 | 363 | 2735 | 790 |
| ENST00000530271 | WNK1 | chr12 | 863490 | - | ENST00000228862 | DUSP16 | chr12 | 12640121 | - | 3164 | 759 | 0 | 2225 | 741 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000535572 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - | 0.009288456 | 0.9907115 |
| ENST00000537687 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - | 0.009955068 | 0.9900449 |
| ENST00000315939 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - | 0.009955068 | 0.9900449 |
| ENST00000447667 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - | 0.011283286 | 0.9887167 |
| ENST00000530271 | ENST00000228862 | WNK1 | chr12 | 863490 | - | DUSP16 | chr12 | 12640121 | - | 0.007643775 | 0.9923562 |
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Fusion Genomic Features for WNK1-DUSP16 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for WNK1-DUSP16 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:863490/chr12:12640121) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | DUSP16 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. {ECO:0000269|PubMed:11489891, ECO:0000269|PubMed:15888437}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | WNK1 | chr12:863490 | chr12:12640121 | ENST00000315939 | - | 1 | 28 | 221_479 | 253 | 2383.0 | Domain | Protein kinase |
| Hgene | WNK1 | chr12:863490 | chr12:12640121 | ENST00000340908 | - | 1 | 25 | 221_479 | 0 | 1976.0 | Domain | Protein kinase |
| Hgene | WNK1 | chr12:863490 | chr12:12640121 | ENST00000537687 | - | 1 | 28 | 221_479 | 253 | 2643.0 | Domain | Protein kinase |
| Hgene | WNK1 | chr12:863490 | chr12:12640121 | ENST00000574564 | - | 1 | 1 | 221_479 | 0 | 435.0 | Domain | Protein kinase |
| Hgene | WNK1 | chr12:863490 | chr12:12640121 | ENST00000315939 | - | 1 | 28 | 301_304 | 253 | 2383.0 | Nucleotide binding | ATP |
| Hgene | WNK1 | chr12:863490 | chr12:12640121 | ENST00000340908 | - | 1 | 25 | 301_304 | 0 | 1976.0 | Nucleotide binding | ATP |
| Hgene | WNK1 | chr12:863490 | chr12:12640121 | ENST00000537687 | - | 1 | 28 | 301_304 | 253 | 2643.0 | Nucleotide binding | ATP |
| Hgene | WNK1 | chr12:863490 | chr12:12640121 | ENST00000574564 | - | 1 | 1 | 301_304 | 0 | 435.0 | Nucleotide binding | ATP |
| Hgene | WNK1 | chr12:863490 | chr12:12640121 | ENST00000315939 | - | 1 | 28 | 488_555 | 253 | 2383.0 | Region | Autoinhibitory domain |
| Hgene | WNK1 | chr12:863490 | chr12:12640121 | ENST00000340908 | - | 1 | 25 | 488_555 | 0 | 1976.0 | Region | Autoinhibitory domain |
| Hgene | WNK1 | chr12:863490 | chr12:12640121 | ENST00000537687 | - | 1 | 28 | 488_555 | 253 | 2643.0 | Region | Autoinhibitory domain |
| Hgene | WNK1 | chr12:863490 | chr12:12640121 | ENST00000574564 | - | 1 | 1 | 488_555 | 0 | 435.0 | Region | Autoinhibitory domain |
| Tgene | DUSP16 | chr12:863490 | chr12:12640121 | ENST00000228862 | 3 | 7 | 158_300 | 177 | 666.0 | Domain | Tyrosine-protein phosphatase | |
| Tgene | DUSP16 | chr12:863490 | chr12:12640121 | ENST00000228862 | 3 | 7 | 22_137 | 177 | 666.0 | Domain | Rhodanese |
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Fusion Gene Sequence for WNK1-DUSP16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >99325_99325_1_WNK1-DUSP16_WNK1_chr12_863490_ENST00000315939_DUSP16_chr12_12640121_ENST00000228862_length(transcript)=3807nt_BP=1402nt CCGGCCCTTCGCCTCTGGGCGATGGGCGACCTGTGAGGCCGGTCCCCATCGCTGGGGGCGCGTGTGGGAGGAGGCGGCCGCCCGAGTGAC CGGGAGCCGGGCCGCGGCCTTCCCTCGCCCGCCTCGGCCCCTCCCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGT CCCGTGCTCGCGGTGCCGCCGCCCTCTGGGCCTAGCCCGCCCAGCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTC GACTCGGTGCCGGCCCCTGGCCCTCCCCTCATGACTGCGGCGCCTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATG CGGACCGTGCGGCGCTAACCCCCGTGGCTCAGCTCCCGAATCGCCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGC CCCCGCCGCAGCTGGGCCCAGCGGTCCGCCTGTCCCTCGTTGCGGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCG CCCGGCCGCGGTTCCCTGCAGACCTCTGCGCGGGCGGCTCGGCCCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTC CAGCGAACCGACCATGTCTGGCGGCGCCGCAGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAA GAATGGCTCCAGCTCCGATTCCTCCGTGGGGGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCG CCGCCGCCACACTATGGACAAGGACAGCCGTGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTG TGACTCCAATGCCACTGCACTGGAGCTTCCCGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCC ACCGGAGCCCCACCGGGAAGAGACCGTGACCGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACA GGCCGTCGCGGGCCCTGCCCCCTCGACTGTCCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGA GGAGCCGCCGCCGGCGAGAAGTGGCAGCGGCGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGA GCTGGAGACCAAGGCCGTGGGAATGTCTAACGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTA CAAAGGTCTGGACACTGAAACCACCGTGGAAGTCGCCTGGTGTGAACTGCAGGAGCTGATGCAGCAGAATGGGATTGGTTATGTGTTAAA TGCCAGCAATACCTGTCCAAAGCCTGACTTTATCCCCGAGTCTCATTTCCTGCGTGTGCCTGTGAATGACAGCTTTTGTGAGAAAATTTT GCCGTGGTTGGACAAATCAGTAGATTTCATTGAGAAAGCAAAAGCCTCCAATGGATGTGTTCTAGTGCACTGTTTAGCTGGGATCTCCCG CTCCGCCACCATCGCTATCGCCTACATCATGAAGAGGATGGACATGTCTTTAGATGAAGCTTACAGATTTGTGAAAGAAAAAAGACCTAC TATATCTCCAAACTTCAATTTTCTGGGCCAACTCCTGGACTATGAGAAGAAGATTAAGAACCAGACTGGAGCATCAGGGCCAAAGAGCAA ACTCAAGCTGCTGCACCTGGAGAAGCCAAATGAACCTGTCCCTGCTGTCTCAGAGGGTGGACAGAAAAGCGAGACGCCCCTCAGTCCACC CTGTGCCGACTCTGCTACCTCAGAGGCAGCAGGACAAAGGCCCGTGCATCCCGCCAGCGTGCCCAGCGTGCCCAGCGTGCAGCCGTCGCT GTTAGAGGACAGCCCGCTGGTACAGGCGCTCAGTGGGCTGCACCTGTCCGCAGACAGGCTGGAAGACAGCAATAAGCTCAAGCGTTCCTT CTCTCTGGATATCAAATCAGTTTCATATTCAGCCAGCATGGCAGCATCCTTACATGGCTTCTCCTCATCAGAAGATGCTTTGGAATACTA CAAACCTTCCACTACTCTGGATGGGACCAACAAGCTATGCCAGTTCTCCCCTGTTCAGGAACTATCGGAGCAGACTCCCGAAACCAGTCC TGATAAGGAGGAAGCCAGCATCCCCAAGAAGCTGCAGACCGCCAGGCCTTCAGACAGCCAGAGCAAGCGATTGCATTCGGTCAGAACCAG CAGCAGTGGCACCGCCCAGAGGTCCCTTTTATCTCCACTGCATCGAAGTGGGAGCGTGGAGGACAATTACCACACCAGCTTCCTTTTCGG CCTTTCCACCAGCCAGCAGCACCTCACGAAGTCTGCTGGCCTGGGCCTTAAGGGCTGGCACTCGGATATCTTGGCCCCCCAGACCTCTAC CCCTTCCCTGACCAGCAGCTGGTATTTTGCCACAGAGTCCTCACACTTCTACTCTGCCTCAGCCATCTACGGAGGCAGTGCCAGTTACTC TGCCTACAGCTGCAGCCAGCTGCCCACTTGCGGAGACCAAGTCTATTCTGTGCGCAGGCGGCAGAAGCCAAGTGACAGAGCTGACTCGCG GCGGAGCTGGCATGAAGAGAGCCCCTTTGAAAAGCAGTTTAAACGCAGAAGCTGCCAAATGGAATTTGGAGAGAGCATCATGTCAGAGAA CAGGTCACGGGAAGAGCTGGGGAAAGTGGGCAGTCAGTCTAGCTTTTCGGGCAGCATGGAAATCATTGAGGTCTCCTGAGAAGAAAGACA CTTGTGACTTCTATAGACAATTTTTTTTTCTTGTTCACAAAAAAATTCCCTGTAAATCTGAAATATATATATGTACATACATATATATTT TTGGAAAATGGAGCTATGGTGTAAAAGCAACAGGTGGATCAACCCAGTTGTTACTCTCTTAACATCTGCATTTGAGAGATCAGCTAATAC TTCTCTCAACAAAAATGGAAGGGCAGATGCTAGAATCCCCCCTAGACGGAGGAAAACCATTTTATTCAGTGAATTACACATCCTCTTGTT CTTAAAAAAGCAAGTGTCTTTGGTGTTGGAGGACAAAATCCCCTACCATTTTCACGTTGTGCTACTAAGAGATCTCAAATATTAGTCTTT GTCCGGACCCTTCCATAGTACACCTTAGCGCTGAGACTGAGCCAGCTTGGGGGTCAGGTAGGTAGACCCTGTTAGGGACAGAGCCTAGTG GTAAATCCAAGAGAAATGATCCTATCCAAAGCTGATTCACAAACCCACGCTCACCTGACAGCCGAGGGACACGAGCATCACTCTGCTGGA CGGACCATTAGGGGCCTTGCCAAGGTCTACCTTAGAGCAAACCCAGTACCTCAGACAGGAAAGTCGGGGCTTTGACCACTACCATATCTG GTAGCCCATTTTCTAGGCATTGTGAATAGGTAGGTAGCTAGTCACACTTTTCAGACCAATTCAAACTGTCTATGCACAAAATTCCCGTGG GCCTAGATGGAGATAATTTTTTTTTCTTCTCAGCTTTATGAAGAGAAGGGAAACTGTCTAGGATTCAGCTGAACCACCAGGAACCTGGCA ACATCACGATTTAAGCTAAGGTTGGGAGGCTAACGAGTCTACCTCCCTCTTTGTAAATCAAAGAATTGTTTAAAATGGGATTGTCAATCC >99325_99325_1_WNK1-DUSP16_WNK1_chr12_863490_ENST00000315939_DUSP16_chr12_12640121_ENST00000228862_length(amino acids)=790AA_BP=302 MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKA SNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQTGASGPKSKLKLLHLEKPNEPVPA VSEGGQKSETPLSPPCADSATSEAAGQRPVHPASVPSVPSVQPSLLEDSPLVQALSGLHLSADRLEDSNKLKRSFSLDIKSVSYSASMAA SLHGFSSSEDALEYYKPSTTLDGTNKLCQFSPVQELSEQTPETSPDKEEASIPKKLQTARPSDSQSKRLHSVRTSSSGTAQRSLLSPLHR SGSVEDNYHTSFLFGLSTSQQHLTKSAGLGLKGWHSDILAPQTSTPSLTSSWYFATESSHFYSASAIYGGSASYSAYSCSQLPTCGDQVY -------------------------------------------------------------- >99325_99325_2_WNK1-DUSP16_WNK1_chr12_863490_ENST00000447667_DUSP16_chr12_12640121_ENST00000228862_length(transcript)=3674nt_BP=1269nt CCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGTCCCGTGCTCGCGGTGCCGCCGCCCTCTGGGCCTAGCCCGCCCA GCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTCGACTCGGTGCCGGCCCCTGGCCCTCCCCTCATGACTGCGGCGC CTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATGCGGACCGTGCGGCGCTAACCCCCGTGGCTCAGCTCCCGAATCG CCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGCCCCCGCCGCAGCTGGGCCCAGCGGTCCGCCTGTCCCTCGTTGC GGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCGCCCGGCCGCGGTTCCCTGCAGACCTCTGCGCGGGCGGCTCGGC CCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTCCAGCGAACCGACCATGTCTGGCGGCGCCGCAGAGAAGCAGAGC AGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAAGAATGGCTCCAGCTCCGATTCCTCCGTGGGGGAGAAACTGGGA GCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCGCCGCCGCCACACTATGGACAAGGACAGCCGTGGGGCGGCCGCG ACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTGTGACTCCAATGCCACTGCACTGGAGCTTCCCGGCCTTCCTCTT TCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCCACCGGAGCCCCACCGGGAAGAGACCGTGACCGCCACCGCCACT TCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACAGGCCGTCGCGGGCCCTGCCCCCTCGACTGTCCCCAGCAGTACC AGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGAGGAGCCGCCGCCGGCGAGAAGTGGCAGCGGCGGCGGCAGCGCC AAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGAGCTGGAGACCAAGGCCGTGGGAATGTCTAACGATGGCCGCTTT CTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTACAAAGGTCTGGACACTGAAACCACCGTGGAAGTCGCCTGGTGT GAACTGCAGGAGCTGATGCAGCAGAATGGGATTGGTTATGTGTTAAATGCCAGCAATACCTGTCCAAAGCCTGACTTTATCCCCGAGTCT CATTTCCTGCGTGTGCCTGTGAATGACAGCTTTTGTGAGAAAATTTTGCCGTGGTTGGACAAATCAGTAGATTTCATTGAGAAAGCAAAA GCCTCCAATGGATGTGTTCTAGTGCACTGTTTAGCTGGGATCTCCCGCTCCGCCACCATCGCTATCGCCTACATCATGAAGAGGATGGAC ATGTCTTTAGATGAAGCTTACAGATTTGTGAAAGAAAAAAGACCTACTATATCTCCAAACTTCAATTTTCTGGGCCAACTCCTGGACTAT GAGAAGAAGATTAAGAACCAGACTGGAGCATCAGGGCCAAAGAGCAAACTCAAGCTGCTGCACCTGGAGAAGCCAAATGAACCTGTCCCT GCTGTCTCAGAGGGTGGACAGAAAAGCGAGACGCCCCTCAGTCCACCCTGTGCCGACTCTGCTACCTCAGAGGCAGCAGGACAAAGGCCC GTGCATCCCGCCAGCGTGCCCAGCGTGCCCAGCGTGCAGCCGTCGCTGTTAGAGGACAGCCCGCTGGTACAGGCGCTCAGTGGGCTGCAC CTGTCCGCAGACAGGCTGGAAGACAGCAATAAGCTCAAGCGTTCCTTCTCTCTGGATATCAAATCAGTTTCATATTCAGCCAGCATGGCA GCATCCTTACATGGCTTCTCCTCATCAGAAGATGCTTTGGAATACTACAAACCTTCCACTACTCTGGATGGGACCAACAAGCTATGCCAG TTCTCCCCTGTTCAGGAACTATCGGAGCAGACTCCCGAAACCAGTCCTGATAAGGAGGAAGCCAGCATCCCCAAGAAGCTGCAGACCGCC AGGCCTTCAGACAGCCAGAGCAAGCGATTGCATTCGGTCAGAACCAGCAGCAGTGGCACCGCCCAGAGGTCCCTTTTATCTCCACTGCAT CGAAGTGGGAGCGTGGAGGACAATTACCACACCAGCTTCCTTTTCGGCCTTTCCACCAGCCAGCAGCACCTCACGAAGTCTGCTGGCCTG GGCCTTAAGGGCTGGCACTCGGATATCTTGGCCCCCCAGACCTCTACCCCTTCCCTGACCAGCAGCTGGTATTTTGCCACAGAGTCCTCA CACTTCTACTCTGCCTCAGCCATCTACGGAGGCAGTGCCAGTTACTCTGCCTACAGCTGCAGCCAGCTGCCCACTTGCGGAGACCAAGTC TATTCTGTGCGCAGGCGGCAGAAGCCAAGTGACAGAGCTGACTCGCGGCGGAGCTGGCATGAAGAGAGCCCCTTTGAAAAGCAGTTTAAA CGCAGAAGCTGCCAAATGGAATTTGGAGAGAGCATCATGTCAGAGAACAGGTCACGGGAAGAGCTGGGGAAAGTGGGCAGTCAGTCTAGC TTTTCGGGCAGCATGGAAATCATTGAGGTCTCCTGAGAAGAAAGACACTTGTGACTTCTATAGACAATTTTTTTTTCTTGTTCACAAAAA AATTCCCTGTAAATCTGAAATATATATATGTACATACATATATATTTTTGGAAAATGGAGCTATGGTGTAAAAGCAACAGGTGGATCAAC CCAGTTGTTACTCTCTTAACATCTGCATTTGAGAGATCAGCTAATACTTCTCTCAACAAAAATGGAAGGGCAGATGCTAGAATCCCCCCT AGACGGAGGAAAACCATTTTATTCAGTGAATTACACATCCTCTTGTTCTTAAAAAAGCAAGTGTCTTTGGTGTTGGAGGACAAAATCCCC TACCATTTTCACGTTGTGCTACTAAGAGATCTCAAATATTAGTCTTTGTCCGGACCCTTCCATAGTACACCTTAGCGCTGAGACTGAGCC AGCTTGGGGGTCAGGTAGGTAGACCCTGTTAGGGACAGAGCCTAGTGGTAAATCCAAGAGAAATGATCCTATCCAAAGCTGATTCACAAA CCCACGCTCACCTGACAGCCGAGGGACACGAGCATCACTCTGCTGGACGGACCATTAGGGGCCTTGCCAAGGTCTACCTTAGAGCAAACC CAGTACCTCAGACAGGAAAGTCGGGGCTTTGACCACTACCATATCTGGTAGCCCATTTTCTAGGCATTGTGAATAGGTAGGTAGCTAGTC ACACTTTTCAGACCAATTCAAACTGTCTATGCACAAAATTCCCGTGGGCCTAGATGGAGATAATTTTTTTTTCTTCTCAGCTTTATGAAG AGAAGGGAAACTGTCTAGGATTCAGCTGAACCACCAGGAACCTGGCAACATCACGATTTAAGCTAAGGTTGGGAGGCTAACGAGTCTACC >99325_99325_2_WNK1-DUSP16_WNK1_chr12_863490_ENST00000447667_DUSP16_chr12_12640121_ENST00000228862_length(amino acids)=790AA_BP=302 MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKA SNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQTGASGPKSKLKLLHLEKPNEPVPA VSEGGQKSETPLSPPCADSATSEAAGQRPVHPASVPSVPSVQPSLLEDSPLVQALSGLHLSADRLEDSNKLKRSFSLDIKSVSYSASMAA SLHGFSSSEDALEYYKPSTTLDGTNKLCQFSPVQELSEQTPETSPDKEEASIPKKLQTARPSDSQSKRLHSVRTSSSGTAQRSLLSPLHR SGSVEDNYHTSFLFGLSTSQQHLTKSAGLGLKGWHSDILAPQTSTPSLTSSWYFATESSHFYSASAIYGGSASYSAYSCSQLPTCGDQVY -------------------------------------------------------------- >99325_99325_3_WNK1-DUSP16_WNK1_chr12_863490_ENST00000530271_DUSP16_chr12_12640121_ENST00000228862_length(transcript)=3164nt_BP=759nt ATGTCTGGCGGCGCCGCAGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAAGAATGGCTCCAGC TCCGATTCCTCCGTGGGGGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCGCCGCCGCCACACT ATGGACAAGGACAGCCGTGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTGTGACTCCAATGCC ACTGCACTGGAGCTTCCCGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCCACCGGAGCCCCAC CGGGAAGAGACCGTGACCGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACAGGCCGTCGCGGGC CCTGCCCCCTCGACTGTCCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGAGGAGCCGCCGCCG GCGAGAAGTGGCAGCGGCGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGAGCTGGAGACCAAG GCCGTGGGAATGTCTAACGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTACAAAGGTCTGGAC ACTGAAACCACCGTGGAAGTCGCCTGGTGTGAACTGCAGGAGCTGATGCAGCAGAATGGGATTGGTTATGTGTTAAATGCCAGCAATACC TGTCCAAAGCCTGACTTTATCCCCGAGTCTCATTTCCTGCGTGTGCCTGTGAATGACAGCTTTTGTGAGAAAATTTTGCCGTGGTTGGAC AAATCAGTAGATTTCATTGAGAAAGCAAAAGCCTCCAATGGATGTGTTCTAGTGCACTGTTTAGCTGGGATCTCCCGCTCCGCCACCATC GCTATCGCCTACATCATGAAGAGGATGGACATGTCTTTAGATGAAGCTTACAGATTTGTGAAAGAAAAAAGACCTACTATATCTCCAAAC TTCAATTTTCTGGGCCAACTCCTGGACTATGAGAAGAAGATTAAGAACCAGACTGGAGCATCAGGGCCAAAGAGCAAACTCAAGCTGCTG CACCTGGAGAAGCCAAATGAACCTGTCCCTGCTGTCTCAGAGGGTGGACAGAAAAGCGAGACGCCCCTCAGTCCACCCTGTGCCGACTCT GCTACCTCAGAGGCAGCAGGACAAAGGCCCGTGCATCCCGCCAGCGTGCCCAGCGTGCCCAGCGTGCAGCCGTCGCTGTTAGAGGACAGC CCGCTGGTACAGGCGCTCAGTGGGCTGCACCTGTCCGCAGACAGGCTGGAAGACAGCAATAAGCTCAAGCGTTCCTTCTCTCTGGATATC AAATCAGTTTCATATTCAGCCAGCATGGCAGCATCCTTACATGGCTTCTCCTCATCAGAAGATGCTTTGGAATACTACAAACCTTCCACT ACTCTGGATGGGACCAACAAGCTATGCCAGTTCTCCCCTGTTCAGGAACTATCGGAGCAGACTCCCGAAACCAGTCCTGATAAGGAGGAA GCCAGCATCCCCAAGAAGCTGCAGACCGCCAGGCCTTCAGACAGCCAGAGCAAGCGATTGCATTCGGTCAGAACCAGCAGCAGTGGCACC GCCCAGAGGTCCCTTTTATCTCCACTGCATCGAAGTGGGAGCGTGGAGGACAATTACCACACCAGCTTCCTTTTCGGCCTTTCCACCAGC CAGCAGCACCTCACGAAGTCTGCTGGCCTGGGCCTTAAGGGCTGGCACTCGGATATCTTGGCCCCCCAGACCTCTACCCCTTCCCTGACC AGCAGCTGGTATTTTGCCACAGAGTCCTCACACTTCTACTCTGCCTCAGCCATCTACGGAGGCAGTGCCAGTTACTCTGCCTACAGCTGC AGCCAGCTGCCCACTTGCGGAGACCAAGTCTATTCTGTGCGCAGGCGGCAGAAGCCAAGTGACAGAGCTGACTCGCGGCGGAGCTGGCAT GAAGAGAGCCCCTTTGAAAAGCAGTTTAAACGCAGAAGCTGCCAAATGGAATTTGGAGAGAGCATCATGTCAGAGAACAGGTCACGGGAA GAGCTGGGGAAAGTGGGCAGTCAGTCTAGCTTTTCGGGCAGCATGGAAATCATTGAGGTCTCCTGAGAAGAAAGACACTTGTGACTTCTA TAGACAATTTTTTTTTCTTGTTCACAAAAAAATTCCCTGTAAATCTGAAATATATATATGTACATACATATATATTTTTGGAAAATGGAG CTATGGTGTAAAAGCAACAGGTGGATCAACCCAGTTGTTACTCTCTTAACATCTGCATTTGAGAGATCAGCTAATACTTCTCTCAACAAA AATGGAAGGGCAGATGCTAGAATCCCCCCTAGACGGAGGAAAACCATTTTATTCAGTGAATTACACATCCTCTTGTTCTTAAAAAAGCAA GTGTCTTTGGTGTTGGAGGACAAAATCCCCTACCATTTTCACGTTGTGCTACTAAGAGATCTCAAATATTAGTCTTTGTCCGGACCCTTC CATAGTACACCTTAGCGCTGAGACTGAGCCAGCTTGGGGGTCAGGTAGGTAGACCCTGTTAGGGACAGAGCCTAGTGGTAAATCCAAGAG AAATGATCCTATCCAAAGCTGATTCACAAACCCACGCTCACCTGACAGCCGAGGGACACGAGCATCACTCTGCTGGACGGACCATTAGGG GCCTTGCCAAGGTCTACCTTAGAGCAAACCCAGTACCTCAGACAGGAAAGTCGGGGCTTTGACCACTACCATATCTGGTAGCCCATTTTC TAGGCATTGTGAATAGGTAGGTAGCTAGTCACACTTTTCAGACCAATTCAAACTGTCTATGCACAAAATTCCCGTGGGCCTAGATGGAGA TAATTTTTTTTTCTTCTCAGCTTTATGAAGAGAAGGGAAACTGTCTAGGATTCAGCTGAACCACCAGGAACCTGGCAACATCACGATTTA AGCTAAGGTTGGGAGGCTAACGAGTCTACCTCCCTCTTTGTAAATCAAAGAATTGTTTAAAATGGGATTGTCAATCCTTTAAATAAAGAT >99325_99325_3_WNK1-DUSP16_WNK1_chr12_863490_ENST00000530271_DUSP16_chr12_12640121_ENST00000228862_length(amino acids)=741AA_BP=253 MSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGAAAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNA TALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATSQVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPP ARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQELMQQNGIGYVLNASNT CPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPN FNFLGQLLDYEKKIKNQTGASGPKSKLKLLHLEKPNEPVPAVSEGGQKSETPLSPPCADSATSEAAGQRPVHPASVPSVPSVQPSLLEDS PLVQALSGLHLSADRLEDSNKLKRSFSLDIKSVSYSASMAASLHGFSSSEDALEYYKPSTTLDGTNKLCQFSPVQELSEQTPETSPDKEE ASIPKKLQTARPSDSQSKRLHSVRTSSSGTAQRSLLSPLHRSGSVEDNYHTSFLFGLSTSQQHLTKSAGLGLKGWHSDILAPQTSTPSLT SSWYFATESSHFYSASAIYGGSASYSAYSCSQLPTCGDQVYSVRRRQKPSDRADSRRSWHEESPFEKQFKRRSCQMEFGESIMSENRSRE -------------------------------------------------------------- >99325_99325_4_WNK1-DUSP16_WNK1_chr12_863490_ENST00000535572_DUSP16_chr12_12640121_ENST00000228862_length(transcript)=4137nt_BP=1732nt ATTTAGCGCGGAGAGTTTCCCGGGTGGACGCGGCTCCTCTCTCGGCCACTCCGCACCCCCATCTTCGGTGACAGAAGGCGCCTGGTGGGG GTGGCTGCTCTTTTCTCTCCCTGTTCCCCCTCACCCAGTCCTCTAGGTCTCCTCTCCTCTTGCCTCAGAGAAGCAGCGGAGCTCGGGCCC CGCGGTGAGCGGCCCTCCCCTCCCCGCCGTTCCCTCCTCCGTCAGCCCCCGGCACCGGCCCGGGAGGAGACGGGTTTGCCAGGCCTGGGG CGGGCGGGGAGGCCTCGGGGAAGGGGGGGCCCGCTCCTCAGGCGCCGAGGCTCCGAGGCTCCGGCCCTTCGCCTCTGGGCGATGGGCGAC CTGTGAGGCCGGTCCCCATCGCTGGGGGCGCGTGTGGGAGGAGGCGGCCGCCCGAGTGACCGGGAGCCGGGCCGCGGCCTTCCCTCGCCC GCCTCGGCCCCTCCCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGTCCCGTGCTCGCGGTGCCGCCGCCCTCTGGG CCTAGCCCGCCCAGCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTCGACTCGGTGCCGGCCCCTGGCCCTCCCCTC ATGACTGCGGCGCCTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATGCGGACCGTGCGGCGCTAACCCCCGTGGCTC AGCTCCCGAATCGCCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGCCCCCGCCGCAGCTGGGCCCAGCGGTCCGCC TGTCCCTCGTTGCGGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCGCCCGGCCGCGGTTCCCTGCAGACCTCTGCG CGGGCGGCTCGGCCCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTCCAGCGAACCGACCATGTCTGGCGGCGCCGC AGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAAGAATGGCTCCAGCTCCGATTCCTCCGTGGG GGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCGCCGCCGCCACACTATGGACAAGGACAGCCG TGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTGTGACTCCAATGCCACTGCACTGGAGCTTCC CGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCCACCGGAGCCCCACCGGGAAGAGACCGTGAC CGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACAGGCCGTCGCGGGCCCTGCCCCCTCGACTGT CCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGAGGAGCCGCCGCCGGCGAGAAGTGGCAGCGG CGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGAGCTGGAGACCAAGGCCGTGGGAATGTCTAA CGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTACAAAGGTCTGGACACTGAAACCACCGTGGA AGTCGCCTGGTGTGAACTGCAGGAGCTGATGCAGCAGAATGGGATTGGTTATGTGTTAAATGCCAGCAATACCTGTCCAAAGCCTGACTT TATCCCCGAGTCTCATTTCCTGCGTGTGCCTGTGAATGACAGCTTTTGTGAGAAAATTTTGCCGTGGTTGGACAAATCAGTAGATTTCAT TGAGAAAGCAAAAGCCTCCAATGGATGTGTTCTAGTGCACTGTTTAGCTGGGATCTCCCGCTCCGCCACCATCGCTATCGCCTACATCAT GAAGAGGATGGACATGTCTTTAGATGAAGCTTACAGATTTGTGAAAGAAAAAAGACCTACTATATCTCCAAACTTCAATTTTCTGGGCCA ACTCCTGGACTATGAGAAGAAGATTAAGAACCAGACTGGAGCATCAGGGCCAAAGAGCAAACTCAAGCTGCTGCACCTGGAGAAGCCAAA TGAACCTGTCCCTGCTGTCTCAGAGGGTGGACAGAAAAGCGAGACGCCCCTCAGTCCACCCTGTGCCGACTCTGCTACCTCAGAGGCAGC AGGACAAAGGCCCGTGCATCCCGCCAGCGTGCCCAGCGTGCCCAGCGTGCAGCCGTCGCTGTTAGAGGACAGCCCGCTGGTACAGGCGCT CAGTGGGCTGCACCTGTCCGCAGACAGGCTGGAAGACAGCAATAAGCTCAAGCGTTCCTTCTCTCTGGATATCAAATCAGTTTCATATTC AGCCAGCATGGCAGCATCCTTACATGGCTTCTCCTCATCAGAAGATGCTTTGGAATACTACAAACCTTCCACTACTCTGGATGGGACCAA CAAGCTATGCCAGTTCTCCCCTGTTCAGGAACTATCGGAGCAGACTCCCGAAACCAGTCCTGATAAGGAGGAAGCCAGCATCCCCAAGAA GCTGCAGACCGCCAGGCCTTCAGACAGCCAGAGCAAGCGATTGCATTCGGTCAGAACCAGCAGCAGTGGCACCGCCCAGAGGTCCCTTTT ATCTCCACTGCATCGAAGTGGGAGCGTGGAGGACAATTACCACACCAGCTTCCTTTTCGGCCTTTCCACCAGCCAGCAGCACCTCACGAA GTCTGCTGGCCTGGGCCTTAAGGGCTGGCACTCGGATATCTTGGCCCCCCAGACCTCTACCCCTTCCCTGACCAGCAGCTGGTATTTTGC CACAGAGTCCTCACACTTCTACTCTGCCTCAGCCATCTACGGAGGCAGTGCCAGTTACTCTGCCTACAGCTGCAGCCAGCTGCCCACTTG CGGAGACCAAGTCTATTCTGTGCGCAGGCGGCAGAAGCCAAGTGACAGAGCTGACTCGCGGCGGAGCTGGCATGAAGAGAGCCCCTTTGA AAAGCAGTTTAAACGCAGAAGCTGCCAAATGGAATTTGGAGAGAGCATCATGTCAGAGAACAGGTCACGGGAAGAGCTGGGGAAAGTGGG CAGTCAGTCTAGCTTTTCGGGCAGCATGGAAATCATTGAGGTCTCCTGAGAAGAAAGACACTTGTGACTTCTATAGACAATTTTTTTTTC TTGTTCACAAAAAAATTCCCTGTAAATCTGAAATATATATATGTACATACATATATATTTTTGGAAAATGGAGCTATGGTGTAAAAGCAA CAGGTGGATCAACCCAGTTGTTACTCTCTTAACATCTGCATTTGAGAGATCAGCTAATACTTCTCTCAACAAAAATGGAAGGGCAGATGC TAGAATCCCCCCTAGACGGAGGAAAACCATTTTATTCAGTGAATTACACATCCTCTTGTTCTTAAAAAAGCAAGTGTCTTTGGTGTTGGA GGACAAAATCCCCTACCATTTTCACGTTGTGCTACTAAGAGATCTCAAATATTAGTCTTTGTCCGGACCCTTCCATAGTACACCTTAGCG CTGAGACTGAGCCAGCTTGGGGGTCAGGTAGGTAGACCCTGTTAGGGACAGAGCCTAGTGGTAAATCCAAGAGAAATGATCCTATCCAAA GCTGATTCACAAACCCACGCTCACCTGACAGCCGAGGGACACGAGCATCACTCTGCTGGACGGACCATTAGGGGCCTTGCCAAGGTCTAC CTTAGAGCAAACCCAGTACCTCAGACAGGAAAGTCGGGGCTTTGACCACTACCATATCTGGTAGCCCATTTTCTAGGCATTGTGAATAGG TAGGTAGCTAGTCACACTTTTCAGACCAATTCAAACTGTCTATGCACAAAATTCCCGTGGGCCTAGATGGAGATAATTTTTTTTTCTTCT CAGCTTTATGAAGAGAAGGGAAACTGTCTAGGATTCAGCTGAACCACCAGGAACCTGGCAACATCACGATTTAAGCTAAGGTTGGGAGGC >99325_99325_4_WNK1-DUSP16_WNK1_chr12_863490_ENST00000535572_DUSP16_chr12_12640121_ENST00000228862_length(amino acids)=790AA_BP=302 MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKA SNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQTGASGPKSKLKLLHLEKPNEPVPA VSEGGQKSETPLSPPCADSATSEAAGQRPVHPASVPSVPSVQPSLLEDSPLVQALSGLHLSADRLEDSNKLKRSFSLDIKSVSYSASMAA SLHGFSSSEDALEYYKPSTTLDGTNKLCQFSPVQELSEQTPETSPDKEEASIPKKLQTARPSDSQSKRLHSVRTSSSGTAQRSLLSPLHR SGSVEDNYHTSFLFGLSTSQQHLTKSAGLGLKGWHSDILAPQTSTPSLTSSWYFATESSHFYSASAIYGGSASYSAYSCSQLPTCGDQVY -------------------------------------------------------------- >99325_99325_5_WNK1-DUSP16_WNK1_chr12_863490_ENST00000537687_DUSP16_chr12_12640121_ENST00000228862_length(transcript)=3807nt_BP=1402nt CCGGCCCTTCGCCTCTGGGCGATGGGCGACCTGTGAGGCCGGTCCCCATCGCTGGGGGCGCGTGTGGGAGGAGGCGGCCGCCCGAGTGAC CGGGAGCCGGGCCGCGGCCTTCCCTCGCCCGCCTCGGCCCCTCCCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGT CCCGTGCTCGCGGTGCCGCCGCCCTCTGGGCCTAGCCCGCCCAGCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTC GACTCGGTGCCGGCCCCTGGCCCTCCCCTCATGACTGCGGCGCCTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATG CGGACCGTGCGGCGCTAACCCCCGTGGCTCAGCTCCCGAATCGCCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGC CCCCGCCGCAGCTGGGCCCAGCGGTCCGCCTGTCCCTCGTTGCGGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCG CCCGGCCGCGGTTCCCTGCAGACCTCTGCGCGGGCGGCTCGGCCCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTC CAGCGAACCGACCATGTCTGGCGGCGCCGCAGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAA GAATGGCTCCAGCTCCGATTCCTCCGTGGGGGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCG CCGCCGCCACACTATGGACAAGGACAGCCGTGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTG TGACTCCAATGCCACTGCACTGGAGCTTCCCGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCC ACCGGAGCCCCACCGGGAAGAGACCGTGACCGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACA GGCCGTCGCGGGCCCTGCCCCCTCGACTGTCCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGA GGAGCCGCCGCCGGCGAGAAGTGGCAGCGGCGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGA GCTGGAGACCAAGGCCGTGGGAATGTCTAACGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTA CAAAGGTCTGGACACTGAAACCACCGTGGAAGTCGCCTGGTGTGAACTGCAGGAGCTGATGCAGCAGAATGGGATTGGTTATGTGTTAAA TGCCAGCAATACCTGTCCAAAGCCTGACTTTATCCCCGAGTCTCATTTCCTGCGTGTGCCTGTGAATGACAGCTTTTGTGAGAAAATTTT GCCGTGGTTGGACAAATCAGTAGATTTCATTGAGAAAGCAAAAGCCTCCAATGGATGTGTTCTAGTGCACTGTTTAGCTGGGATCTCCCG CTCCGCCACCATCGCTATCGCCTACATCATGAAGAGGATGGACATGTCTTTAGATGAAGCTTACAGATTTGTGAAAGAAAAAAGACCTAC TATATCTCCAAACTTCAATTTTCTGGGCCAACTCCTGGACTATGAGAAGAAGATTAAGAACCAGACTGGAGCATCAGGGCCAAAGAGCAA ACTCAAGCTGCTGCACCTGGAGAAGCCAAATGAACCTGTCCCTGCTGTCTCAGAGGGTGGACAGAAAAGCGAGACGCCCCTCAGTCCACC CTGTGCCGACTCTGCTACCTCAGAGGCAGCAGGACAAAGGCCCGTGCATCCCGCCAGCGTGCCCAGCGTGCCCAGCGTGCAGCCGTCGCT GTTAGAGGACAGCCCGCTGGTACAGGCGCTCAGTGGGCTGCACCTGTCCGCAGACAGGCTGGAAGACAGCAATAAGCTCAAGCGTTCCTT CTCTCTGGATATCAAATCAGTTTCATATTCAGCCAGCATGGCAGCATCCTTACATGGCTTCTCCTCATCAGAAGATGCTTTGGAATACTA CAAACCTTCCACTACTCTGGATGGGACCAACAAGCTATGCCAGTTCTCCCCTGTTCAGGAACTATCGGAGCAGACTCCCGAAACCAGTCC TGATAAGGAGGAAGCCAGCATCCCCAAGAAGCTGCAGACCGCCAGGCCTTCAGACAGCCAGAGCAAGCGATTGCATTCGGTCAGAACCAG CAGCAGTGGCACCGCCCAGAGGTCCCTTTTATCTCCACTGCATCGAAGTGGGAGCGTGGAGGACAATTACCACACCAGCTTCCTTTTCGG CCTTTCCACCAGCCAGCAGCACCTCACGAAGTCTGCTGGCCTGGGCCTTAAGGGCTGGCACTCGGATATCTTGGCCCCCCAGACCTCTAC CCCTTCCCTGACCAGCAGCTGGTATTTTGCCACAGAGTCCTCACACTTCTACTCTGCCTCAGCCATCTACGGAGGCAGTGCCAGTTACTC TGCCTACAGCTGCAGCCAGCTGCCCACTTGCGGAGACCAAGTCTATTCTGTGCGCAGGCGGCAGAAGCCAAGTGACAGAGCTGACTCGCG GCGGAGCTGGCATGAAGAGAGCCCCTTTGAAAAGCAGTTTAAACGCAGAAGCTGCCAAATGGAATTTGGAGAGAGCATCATGTCAGAGAA CAGGTCACGGGAAGAGCTGGGGAAAGTGGGCAGTCAGTCTAGCTTTTCGGGCAGCATGGAAATCATTGAGGTCTCCTGAGAAGAAAGACA CTTGTGACTTCTATAGACAATTTTTTTTTCTTGTTCACAAAAAAATTCCCTGTAAATCTGAAATATATATATGTACATACATATATATTT TTGGAAAATGGAGCTATGGTGTAAAAGCAACAGGTGGATCAACCCAGTTGTTACTCTCTTAACATCTGCATTTGAGAGATCAGCTAATAC TTCTCTCAACAAAAATGGAAGGGCAGATGCTAGAATCCCCCCTAGACGGAGGAAAACCATTTTATTCAGTGAATTACACATCCTCTTGTT CTTAAAAAAGCAAGTGTCTTTGGTGTTGGAGGACAAAATCCCCTACCATTTTCACGTTGTGCTACTAAGAGATCTCAAATATTAGTCTTT GTCCGGACCCTTCCATAGTACACCTTAGCGCTGAGACTGAGCCAGCTTGGGGGTCAGGTAGGTAGACCCTGTTAGGGACAGAGCCTAGTG GTAAATCCAAGAGAAATGATCCTATCCAAAGCTGATTCACAAACCCACGCTCACCTGACAGCCGAGGGACACGAGCATCACTCTGCTGGA CGGACCATTAGGGGCCTTGCCAAGGTCTACCTTAGAGCAAACCCAGTACCTCAGACAGGAAAGTCGGGGCTTTGACCACTACCATATCTG GTAGCCCATTTTCTAGGCATTGTGAATAGGTAGGTAGCTAGTCACACTTTTCAGACCAATTCAAACTGTCTATGCACAAAATTCCCGTGG GCCTAGATGGAGATAATTTTTTTTTCTTCTCAGCTTTATGAAGAGAAGGGAAACTGTCTAGGATTCAGCTGAACCACCAGGAACCTGGCA ACATCACGATTTAAGCTAAGGTTGGGAGGCTAACGAGTCTACCTCCCTCTTTGTAAATCAAAGAATTGTTTAAAATGGGATTGTCAATCC >99325_99325_5_WNK1-DUSP16_WNK1_chr12_863490_ENST00000537687_DUSP16_chr12_12640121_ENST00000228862_length(amino acids)=790AA_BP=302 MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKA SNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQTGASGPKSKLKLLHLEKPNEPVPA VSEGGQKSETPLSPPCADSATSEAAGQRPVHPASVPSVPSVQPSLLEDSPLVQALSGLHLSADRLEDSNKLKRSFSLDIKSVSYSASMAA SLHGFSSSEDALEYYKPSTTLDGTNKLCQFSPVQELSEQTPETSPDKEEASIPKKLQTARPSDSQSKRLHSVRTSSSGTAQRSLLSPLHR SGSVEDNYHTSFLFGLSTSQQHLTKSAGLGLKGWHSDILAPQTSTPSLTSSWYFATESSHFYSASAIYGGSASYSAYSCSQLPTCGDQVY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for WNK1-DUSP16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for WNK1-DUSP16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for WNK1-DUSP16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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