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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WNK1-KDM5A (FusionGDB2 ID:99334)

Fusion Gene Summary for WNK1-KDM5A

check button Fusion gene summary
Fusion gene informationFusion gene name: WNK1-KDM5A
Fusion gene ID: 99334
HgeneTgene
Gene symbol

WNK1

KDM5A

Gene ID

65125

5927

Gene nameWNK lysine deficient protein kinase 1lysine demethylase 5A
SynonymsHSAN2|HSN2|KDP|PPP1R167|PRKWNK1|PSK|p65RBBP-2|RBBP2|RBP2
Cytomap

12p13.33

12p13.33

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase WNK1WNK lysine deficient protein kinase 1 isoformerythrocyte 65 kDa proteinprostate-derived sterile 20-like kinaseprotein kinase with no lysine 1protein phosphatase 1, regulatory subunit 167serine/threonine-protein kilysine-specific demethylase 5AJumonji, AT rich interactive domain 1A (RBP2-like)histone demethylase JARID1Ajumonji/ARID domain-containing protein 1Alysine (K)-specific demethylase 5Aretinoblastoma binding protein 2
Modification date2020032720200313
UniProtAcc.

P29375

Ensembl transtripts involved in fusion geneENST00000540360, ENST00000315939, 
ENST00000530271, ENST00000535572, 
ENST00000537687, ENST00000340908, 
ENST00000447667, ENST00000574564, 
ENST00000399788, ENST00000382815, 
ENST00000540838, 
Fusion gene scores* DoF score23 X 19 X 15=655510 X 11 X 4=440
# samples 3710
** MAII scorelog2(37/6555*10)=-4.14699860459281
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/440*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WNK1 [Title/Abstract] AND KDM5A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWNK1(939326)-KDM5A(432947), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWNK1

GO:0006468

protein phosphorylation

10660600

HgeneWNK1

GO:0010923

negative regulation of phosphatase activity

19389623

HgeneWNK1

GO:0023016

signal transduction by trans-phosphorylation

16669787

HgeneWNK1

GO:0035556

intracellular signal transduction

10660600

TgeneKDM5A

GO:0034720

histone H3-K4 demethylation

18270511

TgeneKDM5A

GO:0045893

positive regulation of transcription, DNA-templated

11358960


check buttonFusion gene breakpoints across WNK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KDM5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0AM-01AWNK1chr12

939326

-KDM5Achr12

432947

-
ChimerDB4BRCATCGA-AN-A0AM-01AWNK1chr12

939326

+KDM5Achr12

432947

-


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Fusion Gene ORF analysis for WNK1-KDM5A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000540360ENST00000399788WNK1chr12

939326

+KDM5Achr12

432947

-
3UTR-intronENST00000540360ENST00000382815WNK1chr12

939326

+KDM5Achr12

432947

-
3UTR-intronENST00000540360ENST00000540838WNK1chr12

939326

+KDM5Achr12

432947

-
5CDS-intronENST00000315939ENST00000382815WNK1chr12

939326

+KDM5Achr12

432947

-
5CDS-intronENST00000315939ENST00000540838WNK1chr12

939326

+KDM5Achr12

432947

-
5CDS-intronENST00000530271ENST00000382815WNK1chr12

939326

+KDM5Achr12

432947

-
5CDS-intronENST00000530271ENST00000540838WNK1chr12

939326

+KDM5Achr12

432947

-
5CDS-intronENST00000535572ENST00000382815WNK1chr12

939326

+KDM5Achr12

432947

-
5CDS-intronENST00000535572ENST00000540838WNK1chr12

939326

+KDM5Achr12

432947

-
5CDS-intronENST00000537687ENST00000382815WNK1chr12

939326

+KDM5Achr12

432947

-
5CDS-intronENST00000537687ENST00000540838WNK1chr12

939326

+KDM5Achr12

432947

-
In-frameENST00000315939ENST00000399788WNK1chr12

939326

+KDM5Achr12

432947

-
In-frameENST00000530271ENST00000399788WNK1chr12

939326

+KDM5Achr12

432947

-
In-frameENST00000535572ENST00000399788WNK1chr12

939326

+KDM5Achr12

432947

-
In-frameENST00000537687ENST00000399788WNK1chr12

939326

+KDM5Achr12

432947

-
intron-3CDSENST00000340908ENST00000399788WNK1chr12

939326

+KDM5Achr12

432947

-
intron-3CDSENST00000447667ENST00000399788WNK1chr12

939326

+KDM5Achr12

432947

-
intron-3CDSENST00000574564ENST00000399788WNK1chr12

939326

+KDM5Achr12

432947

-
intron-intronENST00000340908ENST00000382815WNK1chr12

939326

+KDM5Achr12

432947

-
intron-intronENST00000340908ENST00000540838WNK1chr12

939326

+KDM5Achr12

432947

-
intron-intronENST00000447667ENST00000382815WNK1chr12

939326

+KDM5Achr12

432947

-
intron-intronENST00000447667ENST00000540838WNK1chr12

939326

+KDM5Achr12

432947

-
intron-intronENST00000574564ENST00000382815WNK1chr12

939326

+KDM5Achr12

432947

-
intron-intronENST00000574564ENST00000540838WNK1chr12

939326

+KDM5Achr12

432947

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535572WNK1chr12939326+ENST00000399788KDM5Achr12432947-10716228482653881520
ENST00000537687WNK1chr12939326+ENST00000399788KDM5Achr12432947-10386195449650581520
ENST00000315939WNK1chr12939326+ENST00000399788KDM5Achr12432947-10386195449650581520
ENST00000530271WNK1chr12939326+ENST00000399788KDM5Achr12432947-97431311044151471

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535572ENST00000399788WNK1chr12939326+KDM5Achr12432947-0.0002988170.9997012
ENST00000537687ENST00000399788WNK1chr12939326+KDM5Achr12432947-0.0002041530.99979585
ENST00000315939ENST00000399788WNK1chr12939326+KDM5Achr12432947-0.0002041530.99979585
ENST00000530271ENST00000399788WNK1chr12939326+KDM5Achr12432947-8.52E-050.99991477

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Fusion Genomic Features for WNK1-KDM5A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WNK1-KDM5A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:939326/chr12:432947)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KDM5A

P29375

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWNK1chr12:939326chr12:432947ENST00000315939+428301_3044372383.0Nucleotide bindingATP
HgeneWNK1chr12:939326chr12:432947ENST00000537687+428301_3044372643.0Nucleotide bindingATP
TgeneKDM5Achr12:939326chr12:432947ENST0000039978813281492_15876561691.0Compositional biasNote=Lys-rich
TgeneKDM5Achr12:939326chr12:432947ENST0000039978813281161_12186561691.0Zinc fingerPHD-type 2
TgeneKDM5Achr12:939326chr12:432947ENST0000039978813281607_16616561691.0Zinc fingerPHD-type 3
TgeneKDM5Achr12:939326chr12:432947ENST000003997881328676_7286561691.0Zinc fingerC5HC2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWNK1chr12:939326chr12:432947ENST00000315939+428221_4794372383.0DomainProtein kinase
HgeneWNK1chr12:939326chr12:432947ENST00000340908+125221_47901976.0DomainProtein kinase
HgeneWNK1chr12:939326chr12:432947ENST00000537687+428221_4794372643.0DomainProtein kinase
HgeneWNK1chr12:939326chr12:432947ENST00000574564+11221_4790435.0DomainProtein kinase
HgeneWNK1chr12:939326chr12:432947ENST00000340908+125301_30401976.0Nucleotide bindingATP
HgeneWNK1chr12:939326chr12:432947ENST00000574564+11301_3040435.0Nucleotide bindingATP
HgeneWNK1chr12:939326chr12:432947ENST00000315939+428488_5554372383.0RegionAutoinhibitory domain
HgeneWNK1chr12:939326chr12:432947ENST00000340908+125488_55501976.0RegionAutoinhibitory domain
HgeneWNK1chr12:939326chr12:432947ENST00000537687+428488_5554372643.0RegionAutoinhibitory domain
HgeneWNK1chr12:939326chr12:432947ENST00000574564+11488_5550435.0RegionAutoinhibitory domain
TgeneKDM5Achr12:939326chr12:432947ENST00000399788132819_606561691.0DomainJmjN
TgeneKDM5Achr12:939326chr12:432947ENST000003997881328437_6036561691.0DomainJmjC
TgeneKDM5Achr12:939326chr12:432947ENST00000399788132884_1746561691.0DomainARID
TgeneKDM5Achr12:939326chr12:432947ENST000003997881328419_4236561691.0MotifGSGFP motif
TgeneKDM5Achr12:939326chr12:432947ENST000003997881328293_3436561691.0Zinc fingerPHD-type 1


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Fusion Gene Sequence for WNK1-KDM5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99334_99334_1_WNK1-KDM5A_WNK1_chr12_939326_ENST00000315939_KDM5A_chr12_432947_ENST00000399788_length(transcript)=10386nt_BP=1954nt
CCGGCCCTTCGCCTCTGGGCGATGGGCGACCTGTGAGGCCGGTCCCCATCGCTGGGGGCGCGTGTGGGAGGAGGCGGCCGCCCGAGTGAC
CGGGAGCCGGGCCGCGGCCTTCCCTCGCCCGCCTCGGCCCCTCCCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGT
CCCGTGCTCGCGGTGCCGCCGCCCTCTGGGCCTAGCCCGCCCAGCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTC
GACTCGGTGCCGGCCCCTGGCCCTCCCCTCATGACTGCGGCGCCTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATG
CGGACCGTGCGGCGCTAACCCCCGTGGCTCAGCTCCCGAATCGCCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGC
CCCCGCCGCAGCTGGGCCCAGCGGTCCGCCTGTCCCTCGTTGCGGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCG
CCCGGCCGCGGTTCCCTGCAGACCTCTGCGCGGGCGGCTCGGCCCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTC
CAGCGAACCGACCATGTCTGGCGGCGCCGCAGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAA
GAATGGCTCCAGCTCCGATTCCTCCGTGGGGGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCG
CCGCCGCCACACTATGGACAAGGACAGCCGTGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTG
TGACTCCAATGCCACTGCACTGGAGCTTCCCGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCC
ACCGGAGCCCCACCGGGAAGAGACCGTGACCGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACA
GGCCGTCGCGGGCCCTGCCCCCTCGACTGTCCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGA
GGAGCCGCCGCCGGCGAGAAGTGGCAGCGGCGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGA
GCTGGAGACCAAGGCCGTGGGAATGTCTAACGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTA
CAAAGGTCTGGACACTGAAACCACCGTGGAAGTCGCCTGGTGTGAACTGCAGGATCGAAAATTAACAAAGTCTGAGAGGCAGAGATTTAA
AGAAGAAGCTGAAATGTTAAAAGGTCTTCAGCATCCCAATATTGTTAGATTTTATGATTCCTGGGAATCCACAGTAAAAGGAAAGAAGTG
CATTGTTTTGGTGACTGAACTTATGACGTCTGGAACACTTAAAACGTATCTGAAAAGGTTTAAAGTGATGAAGATCAAAGTTCTAAGAAG
CTGGTGCCGTCAGATCCTTAAAGGTCTTCAGTTTCTTCATACTCGAACTCCACCTATCATTCACCGCGATCTTAAATGTGACAACATCTT
TATCACCGGCCCTACTGGCTCAGTCAAGATTGGAGACCTCGGTCTGGCAACCCTGAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTAC
CCCAGAGTTCATGGCCCCTGAGATGTATGAGGAGAAATATGATGAATCCGTTGACGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGC
TACATCTGAATATCCTTACTCGGAGTGCCAAAATGCTGCACAGATCTACCGTCGCGTGACCAGTGGTGTCCTGATGTCAGAAGAAGAAGT
GTTTGAACTTGTTCCTGATGATGAGCGGCAGTGTTCAGCATGCAGAACCACATGTTTTCTCTCTGCTCTCACATGTTCCTGTAATCCTGA
GCGGCTTGTATGTCTCTACCATCCAACTGATCTGTGCCCCTGCCCCATGCAGAAGAAATGTCTTAGATATCGCTACCCATTAGAAGACCT
CCCTTCTCTGCTATATGGTGTAAAAGTCAGGGCACAGTCCTATGACACTTGGGTCAGTCGTGTTACAGAAGCATTGTCTGCTAACTTCAA
CCACAAAAAAGATTTGATTGAATTGCGAGTAATGCTGGAAGATGCTGAGGATAGGAAATACCCAGAGAATGATCTCTTTCGAAAACTCAG
GGATGCTGTAAAAGAAGCTGAGACCTGTGCTTCTGTGGCTCAGCTGCTTCTGAGCAAAAAGCAGAAACACAGACAGAGCCCAGATAGTGG
GAGGACTCGGACCAAACTGACAGTGGAAGAATTGAAGGCCTTTGTCCAACAACTTTTTAGTCTTCCGTGTGTCATCAGCCAAGCTCGGCA
AGTAAAGAATCTGCTAGATGATGTGGAAGAGTTTCATGAACGTGCTCAGGAGGCCATGATGGATGAAACCCCAGATTCTTCCAAACTCCA
GATGTTGATAGATATGGGCTCTAGTCTCTATGTGGAACTCCCTGAATTACCACGACTGAAGCAAGAGCTACAACAGGCTCGGTGGTTGGA
CGAAGTAAGACTGACCTTATCAGATCCGCAACAAGTCACTTTGGATGTCATGAAGAAGCTGATAGACTCTGGGGTAGGGTTGGCACCCCA
CCATGCTGTGGAGAAAGCAATGGCTGAACTACAGGAGCTCCTTACAGTCTCTGAACGATGGGAAGAAAAGGCTAAGGTCTGCCTACAGGC
AAGACCGAGGCACAGTGTGGCAAGTTTAGAAAGCATTGTGAATGAAGCCAAGAACATTCCAGCCTTTCTACCCAATGTGTTGTCCTTGAA
AGAAGCCTTACAAAAGGCTCGAGAATGGACCGCTAAAGTGGAAGCTATTCAGAGTGGCAGCAATTACGCTTATTTGGAGCAGCTTGAGAG
CTTGTCTGCGAAAGGACGCCCTATTCCTGTGCGTCTTGAAGCACTGCCGCAAGTGGAATCACAGGTAGCAGCAGCACGGGCATGGAGAGA
ACGGACTGGGCGGACGTTTCTTAAGAAGAATTCTAGCCATACATTGTTACAGGTGCTGAGCCCCCGGACCGACATTGGTGTATATGGGAG
TGGCAAAAATAGGAGGAAAAAAGTAAAAGAACTAATAGAAAAAGAAAAAGAAAAGGATCTGGACCTGGAGCCTCTGAGTGATCTGGAGGA
AGGATTGGAGGAAACCAGAGATACAGCCATGGTGGTGGCAGTTTTCAAAGAACGGGAGCAAAAAGAGATTGAAGCCATGCATTCTCTCAG
AGCAGCCAACCTAGCCAAGATGACAATGGTGGACCGCATAGAAGAAGTAAAATTTTGCATTTGCCGCAAGACAGCCAGTGGGTTTATGCT
ACAGTGTGAGCTCTGCAAAGACTGGTTCCATAACAGCTGTGTTCCTCTTCCTAAATCAAGTTCCCAAAAAAAAGGATCCAGCTGGCAAGC
TAAAGAAGTAAAATTCCTTTGCCCTCTTTGTATGCGGTCTCGAAGGCCCAGGCTAGAGACTATTCTGTCACTCCTGGTATCCCTTCAGAA
GTTGCCCGTACGGTTGCCTGAAGGAGAGGCCCTGCAGTGTTTGACAGAACGTGCTATGAGTTGGCAAGATAGAGCGCGGCAGGCTCTAGC
CACAGATGAACTATCCTCTGCCCTGGCCAAACTATCTGTGTTGAGCCAGCGTATGGTGGAACAGGCGGCTCGAGAAAAAACTGAAAAGAT
CATCAGTGCAGAACTCCAAAAAGCAGCTGCCAATCCAGACTTACAGGGACACTTACCTAGTTTCCAGCAGTCTGCTTTTAACCGGGTGGT
GAGCAGTGTGTCATCTTCTCCTCGACAAACAATGGACTATGATGATGAAGAAACAGACTCTGATGAAGACATTCGAGAGACATATGGCTA
CGACATGAAGGACACAGCCAGTGTGAAGTCCTCTAGTAGTCTTGAACCCAATCTTTTTTGTGATGAAGAGATTCCCATCAAATCCGAGGA
GGTGGTGACCCACATGTGGACAGCACCTTCATTTTGTGCAGAGCATGCTTATTCTTCTGCTTCTAAGAGTTGTTCTCAAGGTTCTAGCAC
CCCAAGGAAACAACCTCGGAAGAGCCCTTTGGTGCCCCGAAGTTTGGAACCTCCAGTGCTGGAGTTGTCACCTGGAGCTAAGGCACAACT
GGAAGAACTTATGATGGTTGGAGATCTCCTGGAAGTATCTCTGGACGAGACTCAACACATATGGCGGATTTTGCAGGCCACACACCCACC
CTCTGAAGACAGATTCTTGCATATCATGGAGGATGACAGCATGGAAGAGAAACCACTAAAAGTGAAAGGAAAGGACTCTTCAGAGAAGAA
ACGGAAACGGAAGCTAGAAAAGGTAGAGCAACTTTTTGGAGAAGGAAAACAGAAGTCCAAGGAGTTAAAGAAAATGGACAAACCTAGAAA
GAAGAAATTAAAATTAGGTGCAGACAAATCAAAGGAGCTGAATAAACTGGCCAAGAAACTAGCAAAAGAAGAAGAGAGAAAGAAAAAGAA
GGAGAAGGCTGCTGCAGCCAAAGTTGAACTTGTGAAAGAGAGCACTGAAAAGAAAAGAGAGAAAAAGGTGCTGGACATCCCCTCAAAGTA
TGACTGGTCAGGAGCAGAGGAGTCTGATGATGAGAATGCTGTGTGCGCAGCACAGAACTGCCAAAGGCCCTGCAAGGACAAGGTAGACTG
GGTACAATGTGATGGTGGCTGTGATGAGTGGTTTCATCAAGTTTGTGTGGGTGTATCTCCAGAAATGGCTGAAAATGAAGATTACATCTG
TATAAACTGTGCAAAGAAGCAGGGGCCAGTTAGCCCAGGTCCAGCACCACCTCCTTCCTTCATAATGAGCTACAAACTACCAATGGAGGA
TCTTAAAGAGACCAGTTAGCAGATGCTTGGTTAGTTTGGGACATGGGGGGACATGGACCACATTGAGACCTTAGTCATCAAGTAGAGTGG
TTTATATCCACTTGGAATGTTGCTTCCAAAGATGAATGGCCTTCAGAGAAAGTCCCCTTAGTGCTGGCTTCCTCTTTGCATGGACTCTGT
GGGTTACATTCTCTATCAACATATCTATGCAGAGGGTGTCTTCTTTGGTACAACAGCCAATATTTCATGTCTCCTTTGAGTGTGGTTTAC
TGCATTAAGGCCAGATGCTTAATTGAGCTCTAGGGTGGCTGGTTAGTATTAATACATTGGTGTGCTAACAGGGCATATAGGATGTGGCTT
TTGTCCAGCTGATAGTAGTTAGAGGCTTACAACTTAGGAGCAGCACCAACTGAAGGTGCTAATTGCTTGGATCTCCTTCATTGGGATAGT
TGGAGAGGGATTGGAGTACCACTTTCCTTCCACTGTTACCTGGTACTTAATGCCCTAAAGATACAACTAGGAGTAACAGGGCCAAAGTTA
TTTCTGTTAGACGTCAAGGAATGGTATCACAGTCTATTGACCTCAGCGATTTGTGCTTGTTTGTGCTAGAAGAACATCCCAAATAGGAGA
ACCTCTCACAAGCTGGGGCAGGTCACCTTATCTTTGTAAGATGAGGATATCATCTAGATCAGAAATCTGACTAGATTGGATTCTGAGGAG
AAGAACCTACTACAAGGCAAGGAGCCGTTTTTTGGCTTTGAAAAGTCTTGCTGTCTTGGGTCTACATTTTAGGGAAGAGCAGGTACATGG
ATCCAGGCTTCTGCCAAAAAAAAAAAGAGAAGAAGATGACGATGATGACCAGTCGTACTATCTTACTGAGCCACAGTGATGCATGCTTTT
CGGGGAAAACTTCATTCACAAGTATTCCAGACACCAGGCTTCAGGCATGGCCATGAGCAAGACCAGCAAATAACAGCTTTTTGCCTTGCA
GCCCTGACCCCAATGTCTGCTGTTTCCAACACTGGTGATTTCTAACTACGGCCCACAGCAGATGCTGTTGAATAACACCATGGCTTCATC
AGAGGATGTGGGGTTGTAGTACCTCTGGGTGATGAAGTTGTTTTAGTAAATCCATTTTTAAAAAAAAAAAAGGACTTGTTTTTACTTTTT
TCTAAATGTCTCTGACTACTGACTGTTCTATACATAGATTATTTTTCCTTTTTTAATATACATATATGAATATATAAATATATATATTTA
CTGTTACCAGCAGCATATGACAGAGTTTCAACATCAAAAATCCATTTGGGGGCTTGCTTTTTCTTTTTTGCTTTAAAAAAAAAAATCCCA
TTCCTTCTTTGTAGTACAAGGAGTTAGCACTCCCTCCTCCATCCCAGCCTGACCAGATCTTCCATTTTGCTTTTGTTCATATAGATAATT
ATATGTCCTTTGTGTGTTGGGACTTGTCCCTGTCTGTTGGGAAACTTGGTCTCACTCTAGTCTGTGCTGGCTCTTTTTTCTTTTGTGTGT
GAATGTTTGAAACTATGGTGCTGTGTCCTCTTCCCTCCTGTTGTGTTCTCTGTTCTTCTTAAGGTATTAGGTAAGCTGTATGTAAACTCT
TATTAGAAGGGGACTAATTTTTTTTTAAAGGACAAAAAAAAAAATGACTAAAAATAGTGTTTTGTCATCACTGTCTGGTGTCTTTATTTT
GGTTTAAAAAAATCTGTGGTTTGACTTAAATTCATCAGTTTTCCTTTTAAAGGGGGGATTGGGGTGGACCTAGCAACAGCTTATAGTTTC
CTCTTCCCTTTTTGCCCCAGTCTCTTTTAAAGAACTGTCTTCTAGTAACTAGAAGTGAAATGTACTGTCCAGTTACAGTTTGAGTGGGTA
TGAGATTTAACTCAAAAGGAATCTTACAAAAAAAAAGATGTTTTCTTATAAAATCCAATTTCTGTAAATGTTTTCTCTGAAGTTCATACT
ACCTACTTTTTATTCATTCTTAATACTGTATAACATTTTGAGTGTTTTGACTTGTTCAGAGGTTTGTTAGTGTTGCTGTGCATATGTCTT
GAGGTCTCATCTGAAGTAAGTTTGTGTATGATCGAAGATTTCAATGGATATTGCAAGGTAACTAATTAACTGATTTCATAAGTTTTCGTT
TTGCCAAGCTAACGATTATCAATTAAGAATTTCCTCTGGTTGATGTTATACAAGAAAGCACAATATTTTTTGCCTGTTGATCTTCTTTGT
AACAGTCTTCAGATATTTGTGGGTTAAAAATTGAATGTAATTTTAAGTGACAGATGCCTGGAATACATTTAAAATTTTTATTTTTCCTTC
CTAATCATCCATTAACTATTCCACTATCAGTGGAGAGTCATGAGGATGCTGAGAAAGTATGAATAGCTTCCTGTCACCTTCTGACGTTTT
GAAACTTAAATATGTCTTTTCGTTGATACTGTGGGATTTTCTGTATTTACTTGACAGTCATGGAGGATTTGGTATGACTTGACCACAGGT
TTAGACCAAGGCTGAGAAGAACAGAAGGGAGAAATTAATGGCAAAACAAAAAATACACAAATCTGCGGTTTTGGAATTAATGAAACAAGA
TTCATCTATTTAAAGAAATGTTGGTGTTCTAATACAAAGCATTATTTTCACTTAGAGAAAATTACTTACTTGCTCCCTTCTGTATTGTAA
TATTTTGTATTAAGACATGATTTAAAATGTCTTTCTACCCTTATCTCCTCTAAACTGCAACTGAAGTTGCAATTCTTCATCATTAGTATT
TTAACTCTGGCAAAGGTTATAGAAAGAAAAATGGAAATATGGTAGGCCTGTGGTATTCTTAAAAGCTAAGTCATTAGAACTATGCAGATC
CCCAAGTTTAAAAGTACAAATACAGCACCAGTAGTTAGCTTTCTAGCTGGGGGAGAAGACAGGAGATTTTTCTTCCACAGATGTTTATTT
TGCTTCCTGATAGGTACTGCAGCAAAGCCATGTTGATGTGTAGATGCATGACTTCCTCACTAAGCTGCTGCACACCAGCTTTGCCTGCAT
GATTCAAATTTGTGCCTCAGTAAAATTATAAATTATTGCATGTCATACCTTGAATAATGGAAACGGCAAACATTAAACCTGTGATTACCC
ATAATGTACTTTAATAATAAAAAACATGGCAGCCAGGTGCAGTAGAGTGCACCTGTGGTCAGGAGGCTGAAGTGGGAAGATTGCTTCAAC
CTGTGAGTTTGAGTCCCGCCTGGTCAACAGCGAGACCCCATGTGTCTGTCTGTCTCTCTCTTTTTTTAAAGGACAGAGGCTAAGCTGTAA
GGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGTGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCT
GCGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCAGGCTGAGCTGTAAGGTTAG
CATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCTAGCAGGTGCCCACAAAATGTCTTTTTGAATTTCTTAATTTTTGGGTTCTGG
ATGCAATTCGTGCACGCCAAGAAACTACTTGCTTGTCAGTATTTTAATTCTGTAGTACATGTGTGTGAATATCAGCCAGTACTTACAGTA
GGAGGATGAACAGAAAAACTGAGAAGACCTGTCTTTCAAAAGATGGGTTTATCCACTTTTTAAGGGAAAAAGTGACAGTTTGGCATGGGA
TTTGAAAAGTGGAAATTGTGGAAAAATTGAGCTGTTGAAGTCCCACATATAACCAGATTTAATAAAGCTTCACATGTGAATTAGCTCCAT
ATGTGTGTAGAAGGTTGCTTTTATAGCAGGTCCTTAAGTACTCCTTTTGAAATTCCTCCTTTTTTTTTAAGTCATACCATTACTTCTTTG
GATATGAATGTCCCAAGTGGTATCTCCTACTGTAGTATGAGGAAGAATGGCTGTTAATGTATTTTTTGAATTTTGGTCTTGTCTTGGCCT
GGATCATATCCAGTCACCACTATGCAACAAATGATGTGCACTGGGCAAGGATATGATGGGTTATGAAAGCTGTATCTTGTTTGTTTTTTC
TTTTGCAGTACTCCAAGTGGTCTAAACAGGAATGTCTTGTAAAACCTCAAGACTCCCTATTGATTATTCCCTTACATATTTATTTACAAT
TTATCAGGGTAATTGGTGGTGCCTTATGAAAAGTATAACTCGATTTCTTGATCTTTGAGCATGTTTTGTGTTTCTTGTGTTTTCTAAAAG
AATATTAGATATGGTTAATTGCATTACATCTAAAAGATTTAAAAAATTGTGTGTATGCTCAGGTTCCCCACACCCATACCCACCCTAACC
CCTGTCATTTACATTGGTGGCAACTTTAAATGGTAACCAAGCAAAAGTACATTTTGATAATGAGTATTGATAATCCTGAGGAAAACTAGT
GAGTATATGGGAGCCACCTTTGACCTGTGCCAAAGCAGTTTCTAATTTCATTTGCTAACTATAAAATAAAGAACTGAGCCAAAATAATTT
GATCAGTGGTGTGATTAGCCTATTATCATTGCTGAGAATAGTGTTTTTGGAGTGTGAAGTGATTCCTGAAGATTTCACCTGCCTTCTGTT
TCCAGCAAGAATCCAGTGATGACCAACACATTTCCTCACTTTTGGTTCTTGAGAAGTTTATCCCTTTGCAACAAACCATTAATAGGGAAA
ACAAGGAAATGCTTTCCCTTTCTCTTTGGCTTCTTAAAGCTCACAACCAATTCAGACCCCAAGTTACTTCAGAGAAGCAAATGGCACCTT
TTCCCCATTGCCAAGGATCCCAGCTTATGCAGATATGAAGGACGGATCATTTCTGAAAATGTTAAGACTCTGCTTGCAGTGGACTTGGCC
TCAGTTTCATGAAATGTGTAACTCTGTATGTGTATGTTAGGAGGAGGGTTGGTTGAAAGAGCGGGGGCAGGGAGGGGAATCTGATTACCT
CTTGGGAAATAATTTTCTTGCCAACAAAAAGATACACTTGAAGTTTCTTAAGGTGGCAAGTCCATTAAAAAAAAAAATTGTGTTGGACCC
TCCCAGTTTAGATCAAGTATTTCTTGGGGGTCTTGCTATTGTGGTTGATACCAATAAATGGAAGATCCAGAATATTTTCATTTAAAGCTC
AACCATTAATTGGAACATGGTGAAACATTGTACACATTGTAAAAGTAGGGAACAGTACAAAAGAATGGAATCAAATACTATATTATGTGA

>99334_99334_1_WNK1-KDM5A_WNK1_chr12_939326_ENST00000315939_KDM5A_chr12_432947_ENST00000399788_length(amino acids)=1520AA_BP=486
MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA
AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS
QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL
KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKT
YLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDE
SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCP
MQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQL
LLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPE
LPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSVASLESIVNE
AKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLEALPQVESQVAAARAWRERTGRTFLKKNSSHTL
LQVLSPRTDIGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVAVFKEREQKEIEAMHSLRAANLAKMTMVDRIEE
VKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKGSSWQAKEVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLT
ERAMSWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPRQTMDYDD
EETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSL
EPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSMEEKPLKVKGKDSSEKKRKRKLEKVEQLFGEG
KQKSKELKKMDKPRKKKLKLGADKSKELNKLAKKLAKEEERKKKKEKAAAAKVELVKESTEKKREKKVLDIPSKYDWSGAEESDDENAVC

--------------------------------------------------------------
>99334_99334_2_WNK1-KDM5A_WNK1_chr12_939326_ENST00000530271_KDM5A_chr12_432947_ENST00000399788_length(transcript)=9743nt_BP=1311nt
ATGTCTGGCGGCGCCGCAGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAAGAATGGCTCCAGC
TCCGATTCCTCCGTGGGGGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCGCCGCCGCCACACT
ATGGACAAGGACAGCCGTGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTGTGACTCCAATGCC
ACTGCACTGGAGCTTCCCGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCCACCGGAGCCCCAC
CGGGAAGAGACCGTGACCGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACAGGCCGTCGCGGGC
CCTGCCCCCTCGACTGTCCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGAGGAGCCGCCGCCG
GCGAGAAGTGGCAGCGGCGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGAGCTGGAGACCAAG
GCCGTGGGAATGTCTAACGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTACAAAGGTCTGGAC
ACTGAAACCACCGTGGAAGTCGCCTGGTGTGAACTGCAGGATCGAAAATTAACAAAGTCTGAGAGGCAGAGATTTAAAGAAGAAGCTGAA
ATGTTAAAAGGTCTTCAGCATCCCAATATTGTTAGATTTTATGATTCCTGGGAATCCACAGTAAAAGGAAAGAAGTGCATTGTTTTGGTG
ACTGAACTTATGACGTCTGGAACACTTAAAACGTATCTGAAAAGGTTTAAAGTGATGAAGATCAAAGTTCTAAGAAGCTGGTGCCGTCAG
ATCCTTAAAGGTCTTCAGTTTCTTCATACTCGAACTCCACCTATCATTCACCGCGATCTTAAATGTGACAACATCTTTATCACCGGCCCT
ACTGGCTCAGTCAAGATTGGAGACCTCGGTCTGGCAACCCTGAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTACCCCAGAGTTCATG
GCCCCTGAGATGTATGAGGAGAAATATGATGAATCCGTTGACGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGCTACATCTGAATAT
CCTTACTCGGAGTGCCAAAATGCTGCACAGATCTACCGTCGCGTGACCAGTGGTGTCCTGATGTCAGAAGAAGAAGTGTTTGAACTTGTT
CCTGATGATGAGCGGCAGTGTTCAGCATGCAGAACCACATGTTTTCTCTCTGCTCTCACATGTTCCTGTAATCCTGAGCGGCTTGTATGT
CTCTACCATCCAACTGATCTGTGCCCCTGCCCCATGCAGAAGAAATGTCTTAGATATCGCTACCCATTAGAAGACCTCCCTTCTCTGCTA
TATGGTGTAAAAGTCAGGGCACAGTCCTATGACACTTGGGTCAGTCGTGTTACAGAAGCATTGTCTGCTAACTTCAACCACAAAAAAGAT
TTGATTGAATTGCGAGTAATGCTGGAAGATGCTGAGGATAGGAAATACCCAGAGAATGATCTCTTTCGAAAACTCAGGGATGCTGTAAAA
GAAGCTGAGACCTGTGCTTCTGTGGCTCAGCTGCTTCTGAGCAAAAAGCAGAAACACAGACAGAGCCCAGATAGTGGGAGGACTCGGACC
AAACTGACAGTGGAAGAATTGAAGGCCTTTGTCCAACAACTTTTTAGTCTTCCGTGTGTCATCAGCCAAGCTCGGCAAGTAAAGAATCTG
CTAGATGATGTGGAAGAGTTTCATGAACGTGCTCAGGAGGCCATGATGGATGAAACCCCAGATTCTTCCAAACTCCAGATGTTGATAGAT
ATGGGCTCTAGTCTCTATGTGGAACTCCCTGAATTACCACGACTGAAGCAAGAGCTACAACAGGCTCGGTGGTTGGACGAAGTAAGACTG
ACCTTATCAGATCCGCAACAAGTCACTTTGGATGTCATGAAGAAGCTGATAGACTCTGGGGTAGGGTTGGCACCCCACCATGCTGTGGAG
AAAGCAATGGCTGAACTACAGGAGCTCCTTACAGTCTCTGAACGATGGGAAGAAAAGGCTAAGGTCTGCCTACAGGCAAGACCGAGGCAC
AGTGTGGCAAGTTTAGAAAGCATTGTGAATGAAGCCAAGAACATTCCAGCCTTTCTACCCAATGTGTTGTCCTTGAAAGAAGCCTTACAA
AAGGCTCGAGAATGGACCGCTAAAGTGGAAGCTATTCAGAGTGGCAGCAATTACGCTTATTTGGAGCAGCTTGAGAGCTTGTCTGCGAAA
GGACGCCCTATTCCTGTGCGTCTTGAAGCACTGCCGCAAGTGGAATCACAGGTAGCAGCAGCACGGGCATGGAGAGAACGGACTGGGCGG
ACGTTTCTTAAGAAGAATTCTAGCCATACATTGTTACAGGTGCTGAGCCCCCGGACCGACATTGGTGTATATGGGAGTGGCAAAAATAGG
AGGAAAAAAGTAAAAGAACTAATAGAAAAAGAAAAAGAAAAGGATCTGGACCTGGAGCCTCTGAGTGATCTGGAGGAAGGATTGGAGGAA
ACCAGAGATACAGCCATGGTGGTGGCAGTTTTCAAAGAACGGGAGCAAAAAGAGATTGAAGCCATGCATTCTCTCAGAGCAGCCAACCTA
GCCAAGATGACAATGGTGGACCGCATAGAAGAAGTAAAATTTTGCATTTGCCGCAAGACAGCCAGTGGGTTTATGCTACAGTGTGAGCTC
TGCAAAGACTGGTTCCATAACAGCTGTGTTCCTCTTCCTAAATCAAGTTCCCAAAAAAAAGGATCCAGCTGGCAAGCTAAAGAAGTAAAA
TTCCTTTGCCCTCTTTGTATGCGGTCTCGAAGGCCCAGGCTAGAGACTATTCTGTCACTCCTGGTATCCCTTCAGAAGTTGCCCGTACGG
TTGCCTGAAGGAGAGGCCCTGCAGTGTTTGACAGAACGTGCTATGAGTTGGCAAGATAGAGCGCGGCAGGCTCTAGCCACAGATGAACTA
TCCTCTGCCCTGGCCAAACTATCTGTGTTGAGCCAGCGTATGGTGGAACAGGCGGCTCGAGAAAAAACTGAAAAGATCATCAGTGCAGAA
CTCCAAAAAGCAGCTGCCAATCCAGACTTACAGGGACACTTACCTAGTTTCCAGCAGTCTGCTTTTAACCGGGTGGTGAGCAGTGTGTCA
TCTTCTCCTCGACAAACAATGGACTATGATGATGAAGAAACAGACTCTGATGAAGACATTCGAGAGACATATGGCTACGACATGAAGGAC
ACAGCCAGTGTGAAGTCCTCTAGTAGTCTTGAACCCAATCTTTTTTGTGATGAAGAGATTCCCATCAAATCCGAGGAGGTGGTGACCCAC
ATGTGGACAGCACCTTCATTTTGTGCAGAGCATGCTTATTCTTCTGCTTCTAAGAGTTGTTCTCAAGGTTCTAGCACCCCAAGGAAACAA
CCTCGGAAGAGCCCTTTGGTGCCCCGAAGTTTGGAACCTCCAGTGCTGGAGTTGTCACCTGGAGCTAAGGCACAACTGGAAGAACTTATG
ATGGTTGGAGATCTCCTGGAAGTATCTCTGGACGAGACTCAACACATATGGCGGATTTTGCAGGCCACACACCCACCCTCTGAAGACAGA
TTCTTGCATATCATGGAGGATGACAGCATGGAAGAGAAACCACTAAAAGTGAAAGGAAAGGACTCTTCAGAGAAGAAACGGAAACGGAAG
CTAGAAAAGGTAGAGCAACTTTTTGGAGAAGGAAAACAGAAGTCCAAGGAGTTAAAGAAAATGGACAAACCTAGAAAGAAGAAATTAAAA
TTAGGTGCAGACAAATCAAAGGAGCTGAATAAACTGGCCAAGAAACTAGCAAAAGAAGAAGAGAGAAAGAAAAAGAAGGAGAAGGCTGCT
GCAGCCAAAGTTGAACTTGTGAAAGAGAGCACTGAAAAGAAAAGAGAGAAAAAGGTGCTGGACATCCCCTCAAAGTATGACTGGTCAGGA
GCAGAGGAGTCTGATGATGAGAATGCTGTGTGCGCAGCACAGAACTGCCAAAGGCCCTGCAAGGACAAGGTAGACTGGGTACAATGTGAT
GGTGGCTGTGATGAGTGGTTTCATCAAGTTTGTGTGGGTGTATCTCCAGAAATGGCTGAAAATGAAGATTACATCTGTATAAACTGTGCA
AAGAAGCAGGGGCCAGTTAGCCCAGGTCCAGCACCACCTCCTTCCTTCATAATGAGCTACAAACTACCAATGGAGGATCTTAAAGAGACC
AGTTAGCAGATGCTTGGTTAGTTTGGGACATGGGGGGACATGGACCACATTGAGACCTTAGTCATCAAGTAGAGTGGTTTATATCCACTT
GGAATGTTGCTTCCAAAGATGAATGGCCTTCAGAGAAAGTCCCCTTAGTGCTGGCTTCCTCTTTGCATGGACTCTGTGGGTTACATTCTC
TATCAACATATCTATGCAGAGGGTGTCTTCTTTGGTACAACAGCCAATATTTCATGTCTCCTTTGAGTGTGGTTTACTGCATTAAGGCCA
GATGCTTAATTGAGCTCTAGGGTGGCTGGTTAGTATTAATACATTGGTGTGCTAACAGGGCATATAGGATGTGGCTTTTGTCCAGCTGAT
AGTAGTTAGAGGCTTACAACTTAGGAGCAGCACCAACTGAAGGTGCTAATTGCTTGGATCTCCTTCATTGGGATAGTTGGAGAGGGATTG
GAGTACCACTTTCCTTCCACTGTTACCTGGTACTTAATGCCCTAAAGATACAACTAGGAGTAACAGGGCCAAAGTTATTTCTGTTAGACG
TCAAGGAATGGTATCACAGTCTATTGACCTCAGCGATTTGTGCTTGTTTGTGCTAGAAGAACATCCCAAATAGGAGAACCTCTCACAAGC
TGGGGCAGGTCACCTTATCTTTGTAAGATGAGGATATCATCTAGATCAGAAATCTGACTAGATTGGATTCTGAGGAGAAGAACCTACTAC
AAGGCAAGGAGCCGTTTTTTGGCTTTGAAAAGTCTTGCTGTCTTGGGTCTACATTTTAGGGAAGAGCAGGTACATGGATCCAGGCTTCTG
CCAAAAAAAAAAAGAGAAGAAGATGACGATGATGACCAGTCGTACTATCTTACTGAGCCACAGTGATGCATGCTTTTCGGGGAAAACTTC
ATTCACAAGTATTCCAGACACCAGGCTTCAGGCATGGCCATGAGCAAGACCAGCAAATAACAGCTTTTTGCCTTGCAGCCCTGACCCCAA
TGTCTGCTGTTTCCAACACTGGTGATTTCTAACTACGGCCCACAGCAGATGCTGTTGAATAACACCATGGCTTCATCAGAGGATGTGGGG
TTGTAGTACCTCTGGGTGATGAAGTTGTTTTAGTAAATCCATTTTTAAAAAAAAAAAAGGACTTGTTTTTACTTTTTTCTAAATGTCTCT
GACTACTGACTGTTCTATACATAGATTATTTTTCCTTTTTTAATATACATATATGAATATATAAATATATATATTTACTGTTACCAGCAG
CATATGACAGAGTTTCAACATCAAAAATCCATTTGGGGGCTTGCTTTTTCTTTTTTGCTTTAAAAAAAAAAATCCCATTCCTTCTTTGTA
GTACAAGGAGTTAGCACTCCCTCCTCCATCCCAGCCTGACCAGATCTTCCATTTTGCTTTTGTTCATATAGATAATTATATGTCCTTTGT
GTGTTGGGACTTGTCCCTGTCTGTTGGGAAACTTGGTCTCACTCTAGTCTGTGCTGGCTCTTTTTTCTTTTGTGTGTGAATGTTTGAAAC
TATGGTGCTGTGTCCTCTTCCCTCCTGTTGTGTTCTCTGTTCTTCTTAAGGTATTAGGTAAGCTGTATGTAAACTCTTATTAGAAGGGGA
CTAATTTTTTTTTAAAGGACAAAAAAAAAAATGACTAAAAATAGTGTTTTGTCATCACTGTCTGGTGTCTTTATTTTGGTTTAAAAAAAT
CTGTGGTTTGACTTAAATTCATCAGTTTTCCTTTTAAAGGGGGGATTGGGGTGGACCTAGCAACAGCTTATAGTTTCCTCTTCCCTTTTT
GCCCCAGTCTCTTTTAAAGAACTGTCTTCTAGTAACTAGAAGTGAAATGTACTGTCCAGTTACAGTTTGAGTGGGTATGAGATTTAACTC
AAAAGGAATCTTACAAAAAAAAAGATGTTTTCTTATAAAATCCAATTTCTGTAAATGTTTTCTCTGAAGTTCATACTACCTACTTTTTAT
TCATTCTTAATACTGTATAACATTTTGAGTGTTTTGACTTGTTCAGAGGTTTGTTAGTGTTGCTGTGCATATGTCTTGAGGTCTCATCTG
AAGTAAGTTTGTGTATGATCGAAGATTTCAATGGATATTGCAAGGTAACTAATTAACTGATTTCATAAGTTTTCGTTTTGCCAAGCTAAC
GATTATCAATTAAGAATTTCCTCTGGTTGATGTTATACAAGAAAGCACAATATTTTTTGCCTGTTGATCTTCTTTGTAACAGTCTTCAGA
TATTTGTGGGTTAAAAATTGAATGTAATTTTAAGTGACAGATGCCTGGAATACATTTAAAATTTTTATTTTTCCTTCCTAATCATCCATT
AACTATTCCACTATCAGTGGAGAGTCATGAGGATGCTGAGAAAGTATGAATAGCTTCCTGTCACCTTCTGACGTTTTGAAACTTAAATAT
GTCTTTTCGTTGATACTGTGGGATTTTCTGTATTTACTTGACAGTCATGGAGGATTTGGTATGACTTGACCACAGGTTTAGACCAAGGCT
GAGAAGAACAGAAGGGAGAAATTAATGGCAAAACAAAAAATACACAAATCTGCGGTTTTGGAATTAATGAAACAAGATTCATCTATTTAA
AGAAATGTTGGTGTTCTAATACAAAGCATTATTTTCACTTAGAGAAAATTACTTACTTGCTCCCTTCTGTATTGTAATATTTTGTATTAA
GACATGATTTAAAATGTCTTTCTACCCTTATCTCCTCTAAACTGCAACTGAAGTTGCAATTCTTCATCATTAGTATTTTAACTCTGGCAA
AGGTTATAGAAAGAAAAATGGAAATATGGTAGGCCTGTGGTATTCTTAAAAGCTAAGTCATTAGAACTATGCAGATCCCCAAGTTTAAAA
GTACAAATACAGCACCAGTAGTTAGCTTTCTAGCTGGGGGAGAAGACAGGAGATTTTTCTTCCACAGATGTTTATTTTGCTTCCTGATAG
GTACTGCAGCAAAGCCATGTTGATGTGTAGATGCATGACTTCCTCACTAAGCTGCTGCACACCAGCTTTGCCTGCATGATTCAAATTTGT
GCCTCAGTAAAATTATAAATTATTGCATGTCATACCTTGAATAATGGAAACGGCAAACATTAAACCTGTGATTACCCATAATGTACTTTA
ATAATAAAAAACATGGCAGCCAGGTGCAGTAGAGTGCACCTGTGGTCAGGAGGCTGAAGTGGGAAGATTGCTTCAACCTGTGAGTTTGAG
TCCCGCCTGGTCAACAGCGAGACCCCATGTGTCTGTCTGTCTCTCTCTTTTTTTAAAGGACAGAGGCTAAGCTGTAAGGTTAGCATGGTT
CTGCCTGGGCTTTGCTTCTGTGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCA
GGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCT
GGGCTTTGCTTCTGCGCTTCTGTGCTAGCAGGTGCCCACAAAATGTCTTTTTGAATTTCTTAATTTTTGGGTTCTGGATGCAATTCGTGC
ACGCCAAGAAACTACTTGCTTGTCAGTATTTTAATTCTGTAGTACATGTGTGTGAATATCAGCCAGTACTTACAGTAGGAGGATGAACAG
AAAAACTGAGAAGACCTGTCTTTCAAAAGATGGGTTTATCCACTTTTTAAGGGAAAAAGTGACAGTTTGGCATGGGATTTGAAAAGTGGA
AATTGTGGAAAAATTGAGCTGTTGAAGTCCCACATATAACCAGATTTAATAAAGCTTCACATGTGAATTAGCTCCATATGTGTGTAGAAG
GTTGCTTTTATAGCAGGTCCTTAAGTACTCCTTTTGAAATTCCTCCTTTTTTTTTAAGTCATACCATTACTTCTTTGGATATGAATGTCC
CAAGTGGTATCTCCTACTGTAGTATGAGGAAGAATGGCTGTTAATGTATTTTTTGAATTTTGGTCTTGTCTTGGCCTGGATCATATCCAG
TCACCACTATGCAACAAATGATGTGCACTGGGCAAGGATATGATGGGTTATGAAAGCTGTATCTTGTTTGTTTTTTCTTTTGCAGTACTC
CAAGTGGTCTAAACAGGAATGTCTTGTAAAACCTCAAGACTCCCTATTGATTATTCCCTTACATATTTATTTACAATTTATCAGGGTAAT
TGGTGGTGCCTTATGAAAAGTATAACTCGATTTCTTGATCTTTGAGCATGTTTTGTGTTTCTTGTGTTTTCTAAAAGAATATTAGATATG
GTTAATTGCATTACATCTAAAAGATTTAAAAAATTGTGTGTATGCTCAGGTTCCCCACACCCATACCCACCCTAACCCCTGTCATTTACA
TTGGTGGCAACTTTAAATGGTAACCAAGCAAAAGTACATTTTGATAATGAGTATTGATAATCCTGAGGAAAACTAGTGAGTATATGGGAG
CCACCTTTGACCTGTGCCAAAGCAGTTTCTAATTTCATTTGCTAACTATAAAATAAAGAACTGAGCCAAAATAATTTGATCAGTGGTGTG
ATTAGCCTATTATCATTGCTGAGAATAGTGTTTTTGGAGTGTGAAGTGATTCCTGAAGATTTCACCTGCCTTCTGTTTCCAGCAAGAATC
CAGTGATGACCAACACATTTCCTCACTTTTGGTTCTTGAGAAGTTTATCCCTTTGCAACAAACCATTAATAGGGAAAACAAGGAAATGCT
TTCCCTTTCTCTTTGGCTTCTTAAAGCTCACAACCAATTCAGACCCCAAGTTACTTCAGAGAAGCAAATGGCACCTTTTCCCCATTGCCA
AGGATCCCAGCTTATGCAGATATGAAGGACGGATCATTTCTGAAAATGTTAAGACTCTGCTTGCAGTGGACTTGGCCTCAGTTTCATGAA
ATGTGTAACTCTGTATGTGTATGTTAGGAGGAGGGTTGGTTGAAAGAGCGGGGGCAGGGAGGGGAATCTGATTACCTCTTGGGAAATAAT
TTTCTTGCCAACAAAAAGATACACTTGAAGTTTCTTAAGGTGGCAAGTCCATTAAAAAAAAAAATTGTGTTGGACCCTCCCAGTTTAGAT
CAAGTATTTCTTGGGGGTCTTGCTATTGTGGTTGATACCAATAAATGGAAGATCCAGAATATTTTCATTTAAAGCTCAACCATTAATTGG
AACATGGTGAAACATTGTACACATTGTAAAAGTAGGGAACAGTACAAAAGAATGGAATCAAATACTATATTATGTGAATAAACTAGAGTG

>99334_99334_2_WNK1-KDM5A_WNK1_chr12_939326_ENST00000530271_KDM5A_chr12_432947_ENST00000399788_length(amino acids)=1471AA_BP=437
MSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGAAAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNA
TALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATSQVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPP
ARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAE
MLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGP
TGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVLMSEEEVFELV
PDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKD
LIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNL
LDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVE
KAMAELQELLTVSERWEEKAKVCLQARPRHSVASLESIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAK
GRPIPVRLEALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEE
TRDTAMVVAVFKEREQKEIEAMHSLRAANLAKMTMVDRIEEVKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKGSSWQAKEVK
FLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAE
LQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPRQTMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTH
MWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDR
FLHIMEDDSMEEKPLKVKGKDSSEKKRKRKLEKVEQLFGEGKQKSKELKKMDKPRKKKLKLGADKSKELNKLAKKLAKEEERKKKKEKAA
AAKVELVKESTEKKREKKVLDIPSKYDWSGAEESDDENAVCAAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVSPEMAENEDYICINCA

--------------------------------------------------------------
>99334_99334_3_WNK1-KDM5A_WNK1_chr12_939326_ENST00000535572_KDM5A_chr12_432947_ENST00000399788_length(transcript)=10716nt_BP=2284nt
ATTTAGCGCGGAGAGTTTCCCGGGTGGACGCGGCTCCTCTCTCGGCCACTCCGCACCCCCATCTTCGGTGACAGAAGGCGCCTGGTGGGG
GTGGCTGCTCTTTTCTCTCCCTGTTCCCCCTCACCCAGTCCTCTAGGTCTCCTCTCCTCTTGCCTCAGAGAAGCAGCGGAGCTCGGGCCC
CGCGGTGAGCGGCCCTCCCCTCCCCGCCGTTCCCTCCTCCGTCAGCCCCCGGCACCGGCCCGGGAGGAGACGGGTTTGCCAGGCCTGGGG
CGGGCGGGGAGGCCTCGGGGAAGGGGGGGCCCGCTCCTCAGGCGCCGAGGCTCCGAGGCTCCGGCCCTTCGCCTCTGGGCGATGGGCGAC
CTGTGAGGCCGGTCCCCATCGCTGGGGGCGCGTGTGGGAGGAGGCGGCCGCCCGAGTGACCGGGAGCCGGGCCGCGGCCTTCCCTCGCCC
GCCTCGGCCCCTCCCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGTCCCGTGCTCGCGGTGCCGCCGCCCTCTGGG
CCTAGCCCGCCCAGCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTCGACTCGGTGCCGGCCCCTGGCCCTCCCCTC
ATGACTGCGGCGCCTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATGCGGACCGTGCGGCGCTAACCCCCGTGGCTC
AGCTCCCGAATCGCCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGCCCCCGCCGCAGCTGGGCCCAGCGGTCCGCC
TGTCCCTCGTTGCGGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCGCCCGGCCGCGGTTCCCTGCAGACCTCTGCG
CGGGCGGCTCGGCCCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTCCAGCGAACCGACCATGTCTGGCGGCGCCGC
AGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAAGAATGGCTCCAGCTCCGATTCCTCCGTGGG
GGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCGCCGCCGCCACACTATGGACAAGGACAGCCG
TGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTGTGACTCCAATGCCACTGCACTGGAGCTTCC
CGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCCACCGGAGCCCCACCGGGAAGAGACCGTGAC
CGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACAGGCCGTCGCGGGCCCTGCCCCCTCGACTGT
CCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGAGGAGCCGCCGCCGGCGAGAAGTGGCAGCGG
CGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGAGCTGGAGACCAAGGCCGTGGGAATGTCTAA
CGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTACAAAGGTCTGGACACTGAAACCACCGTGGA
AGTCGCCTGGTGTGAACTGCAGGATCGAAAATTAACAAAGTCTGAGAGGCAGAGATTTAAAGAAGAAGCTGAAATGTTAAAAGGTCTTCA
GCATCCCAATATTGTTAGATTTTATGATTCCTGGGAATCCACAGTAAAAGGAAAGAAGTGCATTGTTTTGGTGACTGAACTTATGACGTC
TGGAACACTTAAAACGTATCTGAAAAGGTTTAAAGTGATGAAGATCAAAGTTCTAAGAAGCTGGTGCCGTCAGATCCTTAAAGGTCTTCA
GTTTCTTCATACTCGAACTCCACCTATCATTCACCGCGATCTTAAATGTGACAACATCTTTATCACCGGCCCTACTGGCTCAGTCAAGAT
TGGAGACCTCGGTCTGGCAACCCTGAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTACCCCAGAGTTCATGGCCCCTGAGATGTATGA
GGAGAAATATGATGAATCCGTTGACGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGCTACATCTGAATATCCTTACTCGGAGTGCCA
AAATGCTGCACAGATCTACCGTCGCGTGACCAGTGGTGTCCTGATGTCAGAAGAAGAAGTGTTTGAACTTGTTCCTGATGATGAGCGGCA
GTGTTCAGCATGCAGAACCACATGTTTTCTCTCTGCTCTCACATGTTCCTGTAATCCTGAGCGGCTTGTATGTCTCTACCATCCAACTGA
TCTGTGCCCCTGCCCCATGCAGAAGAAATGTCTTAGATATCGCTACCCATTAGAAGACCTCCCTTCTCTGCTATATGGTGTAAAAGTCAG
GGCACAGTCCTATGACACTTGGGTCAGTCGTGTTACAGAAGCATTGTCTGCTAACTTCAACCACAAAAAAGATTTGATTGAATTGCGAGT
AATGCTGGAAGATGCTGAGGATAGGAAATACCCAGAGAATGATCTCTTTCGAAAACTCAGGGATGCTGTAAAAGAAGCTGAGACCTGTGC
TTCTGTGGCTCAGCTGCTTCTGAGCAAAAAGCAGAAACACAGACAGAGCCCAGATAGTGGGAGGACTCGGACCAAACTGACAGTGGAAGA
ATTGAAGGCCTTTGTCCAACAACTTTTTAGTCTTCCGTGTGTCATCAGCCAAGCTCGGCAAGTAAAGAATCTGCTAGATGATGTGGAAGA
GTTTCATGAACGTGCTCAGGAGGCCATGATGGATGAAACCCCAGATTCTTCCAAACTCCAGATGTTGATAGATATGGGCTCTAGTCTCTA
TGTGGAACTCCCTGAATTACCACGACTGAAGCAAGAGCTACAACAGGCTCGGTGGTTGGACGAAGTAAGACTGACCTTATCAGATCCGCA
ACAAGTCACTTTGGATGTCATGAAGAAGCTGATAGACTCTGGGGTAGGGTTGGCACCCCACCATGCTGTGGAGAAAGCAATGGCTGAACT
ACAGGAGCTCCTTACAGTCTCTGAACGATGGGAAGAAAAGGCTAAGGTCTGCCTACAGGCAAGACCGAGGCACAGTGTGGCAAGTTTAGA
AAGCATTGTGAATGAAGCCAAGAACATTCCAGCCTTTCTACCCAATGTGTTGTCCTTGAAAGAAGCCTTACAAAAGGCTCGAGAATGGAC
CGCTAAAGTGGAAGCTATTCAGAGTGGCAGCAATTACGCTTATTTGGAGCAGCTTGAGAGCTTGTCTGCGAAAGGACGCCCTATTCCTGT
GCGTCTTGAAGCACTGCCGCAAGTGGAATCACAGGTAGCAGCAGCACGGGCATGGAGAGAACGGACTGGGCGGACGTTTCTTAAGAAGAA
TTCTAGCCATACATTGTTACAGGTGCTGAGCCCCCGGACCGACATTGGTGTATATGGGAGTGGCAAAAATAGGAGGAAAAAAGTAAAAGA
ACTAATAGAAAAAGAAAAAGAAAAGGATCTGGACCTGGAGCCTCTGAGTGATCTGGAGGAAGGATTGGAGGAAACCAGAGATACAGCCAT
GGTGGTGGCAGTTTTCAAAGAACGGGAGCAAAAAGAGATTGAAGCCATGCATTCTCTCAGAGCAGCCAACCTAGCCAAGATGACAATGGT
GGACCGCATAGAAGAAGTAAAATTTTGCATTTGCCGCAAGACAGCCAGTGGGTTTATGCTACAGTGTGAGCTCTGCAAAGACTGGTTCCA
TAACAGCTGTGTTCCTCTTCCTAAATCAAGTTCCCAAAAAAAAGGATCCAGCTGGCAAGCTAAAGAAGTAAAATTCCTTTGCCCTCTTTG
TATGCGGTCTCGAAGGCCCAGGCTAGAGACTATTCTGTCACTCCTGGTATCCCTTCAGAAGTTGCCCGTACGGTTGCCTGAAGGAGAGGC
CCTGCAGTGTTTGACAGAACGTGCTATGAGTTGGCAAGATAGAGCGCGGCAGGCTCTAGCCACAGATGAACTATCCTCTGCCCTGGCCAA
ACTATCTGTGTTGAGCCAGCGTATGGTGGAACAGGCGGCTCGAGAAAAAACTGAAAAGATCATCAGTGCAGAACTCCAAAAAGCAGCTGC
CAATCCAGACTTACAGGGACACTTACCTAGTTTCCAGCAGTCTGCTTTTAACCGGGTGGTGAGCAGTGTGTCATCTTCTCCTCGACAAAC
AATGGACTATGATGATGAAGAAACAGACTCTGATGAAGACATTCGAGAGACATATGGCTACGACATGAAGGACACAGCCAGTGTGAAGTC
CTCTAGTAGTCTTGAACCCAATCTTTTTTGTGATGAAGAGATTCCCATCAAATCCGAGGAGGTGGTGACCCACATGTGGACAGCACCTTC
ATTTTGTGCAGAGCATGCTTATTCTTCTGCTTCTAAGAGTTGTTCTCAAGGTTCTAGCACCCCAAGGAAACAACCTCGGAAGAGCCCTTT
GGTGCCCCGAAGTTTGGAACCTCCAGTGCTGGAGTTGTCACCTGGAGCTAAGGCACAACTGGAAGAACTTATGATGGTTGGAGATCTCCT
GGAAGTATCTCTGGACGAGACTCAACACATATGGCGGATTTTGCAGGCCACACACCCACCCTCTGAAGACAGATTCTTGCATATCATGGA
GGATGACAGCATGGAAGAGAAACCACTAAAAGTGAAAGGAAAGGACTCTTCAGAGAAGAAACGGAAACGGAAGCTAGAAAAGGTAGAGCA
ACTTTTTGGAGAAGGAAAACAGAAGTCCAAGGAGTTAAAGAAAATGGACAAACCTAGAAAGAAGAAATTAAAATTAGGTGCAGACAAATC
AAAGGAGCTGAATAAACTGGCCAAGAAACTAGCAAAAGAAGAAGAGAGAAAGAAAAAGAAGGAGAAGGCTGCTGCAGCCAAAGTTGAACT
TGTGAAAGAGAGCACTGAAAAGAAAAGAGAGAAAAAGGTGCTGGACATCCCCTCAAAGTATGACTGGTCAGGAGCAGAGGAGTCTGATGA
TGAGAATGCTGTGTGCGCAGCACAGAACTGCCAAAGGCCCTGCAAGGACAAGGTAGACTGGGTACAATGTGATGGTGGCTGTGATGAGTG
GTTTCATCAAGTTTGTGTGGGTGTATCTCCAGAAATGGCTGAAAATGAAGATTACATCTGTATAAACTGTGCAAAGAAGCAGGGGCCAGT
TAGCCCAGGTCCAGCACCACCTCCTTCCTTCATAATGAGCTACAAACTACCAATGGAGGATCTTAAAGAGACCAGTTAGCAGATGCTTGG
TTAGTTTGGGACATGGGGGGACATGGACCACATTGAGACCTTAGTCATCAAGTAGAGTGGTTTATATCCACTTGGAATGTTGCTTCCAAA
GATGAATGGCCTTCAGAGAAAGTCCCCTTAGTGCTGGCTTCCTCTTTGCATGGACTCTGTGGGTTACATTCTCTATCAACATATCTATGC
AGAGGGTGTCTTCTTTGGTACAACAGCCAATATTTCATGTCTCCTTTGAGTGTGGTTTACTGCATTAAGGCCAGATGCTTAATTGAGCTC
TAGGGTGGCTGGTTAGTATTAATACATTGGTGTGCTAACAGGGCATATAGGATGTGGCTTTTGTCCAGCTGATAGTAGTTAGAGGCTTAC
AACTTAGGAGCAGCACCAACTGAAGGTGCTAATTGCTTGGATCTCCTTCATTGGGATAGTTGGAGAGGGATTGGAGTACCACTTTCCTTC
CACTGTTACCTGGTACTTAATGCCCTAAAGATACAACTAGGAGTAACAGGGCCAAAGTTATTTCTGTTAGACGTCAAGGAATGGTATCAC
AGTCTATTGACCTCAGCGATTTGTGCTTGTTTGTGCTAGAAGAACATCCCAAATAGGAGAACCTCTCACAAGCTGGGGCAGGTCACCTTA
TCTTTGTAAGATGAGGATATCATCTAGATCAGAAATCTGACTAGATTGGATTCTGAGGAGAAGAACCTACTACAAGGCAAGGAGCCGTTT
TTTGGCTTTGAAAAGTCTTGCTGTCTTGGGTCTACATTTTAGGGAAGAGCAGGTACATGGATCCAGGCTTCTGCCAAAAAAAAAAAGAGA
AGAAGATGACGATGATGACCAGTCGTACTATCTTACTGAGCCACAGTGATGCATGCTTTTCGGGGAAAACTTCATTCACAAGTATTCCAG
ACACCAGGCTTCAGGCATGGCCATGAGCAAGACCAGCAAATAACAGCTTTTTGCCTTGCAGCCCTGACCCCAATGTCTGCTGTTTCCAAC
ACTGGTGATTTCTAACTACGGCCCACAGCAGATGCTGTTGAATAACACCATGGCTTCATCAGAGGATGTGGGGTTGTAGTACCTCTGGGT
GATGAAGTTGTTTTAGTAAATCCATTTTTAAAAAAAAAAAAGGACTTGTTTTTACTTTTTTCTAAATGTCTCTGACTACTGACTGTTCTA
TACATAGATTATTTTTCCTTTTTTAATATACATATATGAATATATAAATATATATATTTACTGTTACCAGCAGCATATGACAGAGTTTCA
ACATCAAAAATCCATTTGGGGGCTTGCTTTTTCTTTTTTGCTTTAAAAAAAAAAATCCCATTCCTTCTTTGTAGTACAAGGAGTTAGCAC
TCCCTCCTCCATCCCAGCCTGACCAGATCTTCCATTTTGCTTTTGTTCATATAGATAATTATATGTCCTTTGTGTGTTGGGACTTGTCCC
TGTCTGTTGGGAAACTTGGTCTCACTCTAGTCTGTGCTGGCTCTTTTTTCTTTTGTGTGTGAATGTTTGAAACTATGGTGCTGTGTCCTC
TTCCCTCCTGTTGTGTTCTCTGTTCTTCTTAAGGTATTAGGTAAGCTGTATGTAAACTCTTATTAGAAGGGGACTAATTTTTTTTTAAAG
GACAAAAAAAAAAATGACTAAAAATAGTGTTTTGTCATCACTGTCTGGTGTCTTTATTTTGGTTTAAAAAAATCTGTGGTTTGACTTAAA
TTCATCAGTTTTCCTTTTAAAGGGGGGATTGGGGTGGACCTAGCAACAGCTTATAGTTTCCTCTTCCCTTTTTGCCCCAGTCTCTTTTAA
AGAACTGTCTTCTAGTAACTAGAAGTGAAATGTACTGTCCAGTTACAGTTTGAGTGGGTATGAGATTTAACTCAAAAGGAATCTTACAAA
AAAAAAGATGTTTTCTTATAAAATCCAATTTCTGTAAATGTTTTCTCTGAAGTTCATACTACCTACTTTTTATTCATTCTTAATACTGTA
TAACATTTTGAGTGTTTTGACTTGTTCAGAGGTTTGTTAGTGTTGCTGTGCATATGTCTTGAGGTCTCATCTGAAGTAAGTTTGTGTATG
ATCGAAGATTTCAATGGATATTGCAAGGTAACTAATTAACTGATTTCATAAGTTTTCGTTTTGCCAAGCTAACGATTATCAATTAAGAAT
TTCCTCTGGTTGATGTTATACAAGAAAGCACAATATTTTTTGCCTGTTGATCTTCTTTGTAACAGTCTTCAGATATTTGTGGGTTAAAAA
TTGAATGTAATTTTAAGTGACAGATGCCTGGAATACATTTAAAATTTTTATTTTTCCTTCCTAATCATCCATTAACTATTCCACTATCAG
TGGAGAGTCATGAGGATGCTGAGAAAGTATGAATAGCTTCCTGTCACCTTCTGACGTTTTGAAACTTAAATATGTCTTTTCGTTGATACT
GTGGGATTTTCTGTATTTACTTGACAGTCATGGAGGATTTGGTATGACTTGACCACAGGTTTAGACCAAGGCTGAGAAGAACAGAAGGGA
GAAATTAATGGCAAAACAAAAAATACACAAATCTGCGGTTTTGGAATTAATGAAACAAGATTCATCTATTTAAAGAAATGTTGGTGTTCT
AATACAAAGCATTATTTTCACTTAGAGAAAATTACTTACTTGCTCCCTTCTGTATTGTAATATTTTGTATTAAGACATGATTTAAAATGT
CTTTCTACCCTTATCTCCTCTAAACTGCAACTGAAGTTGCAATTCTTCATCATTAGTATTTTAACTCTGGCAAAGGTTATAGAAAGAAAA
ATGGAAATATGGTAGGCCTGTGGTATTCTTAAAAGCTAAGTCATTAGAACTATGCAGATCCCCAAGTTTAAAAGTACAAATACAGCACCA
GTAGTTAGCTTTCTAGCTGGGGGAGAAGACAGGAGATTTTTCTTCCACAGATGTTTATTTTGCTTCCTGATAGGTACTGCAGCAAAGCCA
TGTTGATGTGTAGATGCATGACTTCCTCACTAAGCTGCTGCACACCAGCTTTGCCTGCATGATTCAAATTTGTGCCTCAGTAAAATTATA
AATTATTGCATGTCATACCTTGAATAATGGAAACGGCAAACATTAAACCTGTGATTACCCATAATGTACTTTAATAATAAAAAACATGGC
AGCCAGGTGCAGTAGAGTGCACCTGTGGTCAGGAGGCTGAAGTGGGAAGATTGCTTCAACCTGTGAGTTTGAGTCCCGCCTGGTCAACAG
CGAGACCCCATGTGTCTGTCTGTCTCTCTCTTTTTTTAAAGGACAGAGGCTAAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTT
CTGTGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCAGGCTGAGCTGTAAGGTT
AGCATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGCGC
TTCTGTGCTAGCAGGTGCCCACAAAATGTCTTTTTGAATTTCTTAATTTTTGGGTTCTGGATGCAATTCGTGCACGCCAAGAAACTACTT
GCTTGTCAGTATTTTAATTCTGTAGTACATGTGTGTGAATATCAGCCAGTACTTACAGTAGGAGGATGAACAGAAAAACTGAGAAGACCT
GTCTTTCAAAAGATGGGTTTATCCACTTTTTAAGGGAAAAAGTGACAGTTTGGCATGGGATTTGAAAAGTGGAAATTGTGGAAAAATTGA
GCTGTTGAAGTCCCACATATAACCAGATTTAATAAAGCTTCACATGTGAATTAGCTCCATATGTGTGTAGAAGGTTGCTTTTATAGCAGG
TCCTTAAGTACTCCTTTTGAAATTCCTCCTTTTTTTTTAAGTCATACCATTACTTCTTTGGATATGAATGTCCCAAGTGGTATCTCCTAC
TGTAGTATGAGGAAGAATGGCTGTTAATGTATTTTTTGAATTTTGGTCTTGTCTTGGCCTGGATCATATCCAGTCACCACTATGCAACAA
ATGATGTGCACTGGGCAAGGATATGATGGGTTATGAAAGCTGTATCTTGTTTGTTTTTTCTTTTGCAGTACTCCAAGTGGTCTAAACAGG
AATGTCTTGTAAAACCTCAAGACTCCCTATTGATTATTCCCTTACATATTTATTTACAATTTATCAGGGTAATTGGTGGTGCCTTATGAA
AAGTATAACTCGATTTCTTGATCTTTGAGCATGTTTTGTGTTTCTTGTGTTTTCTAAAAGAATATTAGATATGGTTAATTGCATTACATC
TAAAAGATTTAAAAAATTGTGTGTATGCTCAGGTTCCCCACACCCATACCCACCCTAACCCCTGTCATTTACATTGGTGGCAACTTTAAA
TGGTAACCAAGCAAAAGTACATTTTGATAATGAGTATTGATAATCCTGAGGAAAACTAGTGAGTATATGGGAGCCACCTTTGACCTGTGC
CAAAGCAGTTTCTAATTTCATTTGCTAACTATAAAATAAAGAACTGAGCCAAAATAATTTGATCAGTGGTGTGATTAGCCTATTATCATT
GCTGAGAATAGTGTTTTTGGAGTGTGAAGTGATTCCTGAAGATTTCACCTGCCTTCTGTTTCCAGCAAGAATCCAGTGATGACCAACACA
TTTCCTCACTTTTGGTTCTTGAGAAGTTTATCCCTTTGCAACAAACCATTAATAGGGAAAACAAGGAAATGCTTTCCCTTTCTCTTTGGC
TTCTTAAAGCTCACAACCAATTCAGACCCCAAGTTACTTCAGAGAAGCAAATGGCACCTTTTCCCCATTGCCAAGGATCCCAGCTTATGC
AGATATGAAGGACGGATCATTTCTGAAAATGTTAAGACTCTGCTTGCAGTGGACTTGGCCTCAGTTTCATGAAATGTGTAACTCTGTATG
TGTATGTTAGGAGGAGGGTTGGTTGAAAGAGCGGGGGCAGGGAGGGGAATCTGATTACCTCTTGGGAAATAATTTTCTTGCCAACAAAAA
GATACACTTGAAGTTTCTTAAGGTGGCAAGTCCATTAAAAAAAAAAATTGTGTTGGACCCTCCCAGTTTAGATCAAGTATTTCTTGGGGG
TCTTGCTATTGTGGTTGATACCAATAAATGGAAGATCCAGAATATTTTCATTTAAAGCTCAACCATTAATTGGAACATGGTGAAACATTG
TACACATTGTAAAAGTAGGGAACAGTACAAAAGAATGGAATCAAATACTATATTATGTGAATAAACTAGAGTGATTTTGGAATTTCACTC

>99334_99334_3_WNK1-KDM5A_WNK1_chr12_939326_ENST00000535572_KDM5A_chr12_432947_ENST00000399788_length(amino acids)=1520AA_BP=486
MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA
AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS
QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL
KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKT
YLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDE
SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCP
MQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQL
LLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPE
LPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSVASLESIVNE
AKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLEALPQVESQVAAARAWRERTGRTFLKKNSSHTL
LQVLSPRTDIGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVAVFKEREQKEIEAMHSLRAANLAKMTMVDRIEE
VKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKGSSWQAKEVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLT
ERAMSWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPRQTMDYDD
EETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSL
EPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSMEEKPLKVKGKDSSEKKRKRKLEKVEQLFGEG
KQKSKELKKMDKPRKKKLKLGADKSKELNKLAKKLAKEEERKKKKEKAAAAKVELVKESTEKKREKKVLDIPSKYDWSGAEESDDENAVC

--------------------------------------------------------------
>99334_99334_4_WNK1-KDM5A_WNK1_chr12_939326_ENST00000537687_KDM5A_chr12_432947_ENST00000399788_length(transcript)=10386nt_BP=1954nt
CCGGCCCTTCGCCTCTGGGCGATGGGCGACCTGTGAGGCCGGTCCCCATCGCTGGGGGCGCGTGTGGGAGGAGGCGGCCGCCCGAGTGAC
CGGGAGCCGGGCCGCGGCCTTCCCTCGCCCGCCTCGGCCCCTCCCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGT
CCCGTGCTCGCGGTGCCGCCGCCCTCTGGGCCTAGCCCGCCCAGCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTC
GACTCGGTGCCGGCCCCTGGCCCTCCCCTCATGACTGCGGCGCCTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATG
CGGACCGTGCGGCGCTAACCCCCGTGGCTCAGCTCCCGAATCGCCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGC
CCCCGCCGCAGCTGGGCCCAGCGGTCCGCCTGTCCCTCGTTGCGGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCG
CCCGGCCGCGGTTCCCTGCAGACCTCTGCGCGGGCGGCTCGGCCCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTC
CAGCGAACCGACCATGTCTGGCGGCGCCGCAGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAA
GAATGGCTCCAGCTCCGATTCCTCCGTGGGGGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCG
CCGCCGCCACACTATGGACAAGGACAGCCGTGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTG
TGACTCCAATGCCACTGCACTGGAGCTTCCCGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCC
ACCGGAGCCCCACCGGGAAGAGACCGTGACCGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACA
GGCCGTCGCGGGCCCTGCCCCCTCGACTGTCCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGA
GGAGCCGCCGCCGGCGAGAAGTGGCAGCGGCGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGA
GCTGGAGACCAAGGCCGTGGGAATGTCTAACGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTA
CAAAGGTCTGGACACTGAAACCACCGTGGAAGTCGCCTGGTGTGAACTGCAGGATCGAAAATTAACAAAGTCTGAGAGGCAGAGATTTAA
AGAAGAAGCTGAAATGTTAAAAGGTCTTCAGCATCCCAATATTGTTAGATTTTATGATTCCTGGGAATCCACAGTAAAAGGAAAGAAGTG
CATTGTTTTGGTGACTGAACTTATGACGTCTGGAACACTTAAAACGTATCTGAAAAGGTTTAAAGTGATGAAGATCAAAGTTCTAAGAAG
CTGGTGCCGTCAGATCCTTAAAGGTCTTCAGTTTCTTCATACTCGAACTCCACCTATCATTCACCGCGATCTTAAATGTGACAACATCTT
TATCACCGGCCCTACTGGCTCAGTCAAGATTGGAGACCTCGGTCTGGCAACCCTGAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTAC
CCCAGAGTTCATGGCCCCTGAGATGTATGAGGAGAAATATGATGAATCCGTTGACGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGC
TACATCTGAATATCCTTACTCGGAGTGCCAAAATGCTGCACAGATCTACCGTCGCGTGACCAGTGGTGTCCTGATGTCAGAAGAAGAAGT
GTTTGAACTTGTTCCTGATGATGAGCGGCAGTGTTCAGCATGCAGAACCACATGTTTTCTCTCTGCTCTCACATGTTCCTGTAATCCTGA
GCGGCTTGTATGTCTCTACCATCCAACTGATCTGTGCCCCTGCCCCATGCAGAAGAAATGTCTTAGATATCGCTACCCATTAGAAGACCT
CCCTTCTCTGCTATATGGTGTAAAAGTCAGGGCACAGTCCTATGACACTTGGGTCAGTCGTGTTACAGAAGCATTGTCTGCTAACTTCAA
CCACAAAAAAGATTTGATTGAATTGCGAGTAATGCTGGAAGATGCTGAGGATAGGAAATACCCAGAGAATGATCTCTTTCGAAAACTCAG
GGATGCTGTAAAAGAAGCTGAGACCTGTGCTTCTGTGGCTCAGCTGCTTCTGAGCAAAAAGCAGAAACACAGACAGAGCCCAGATAGTGG
GAGGACTCGGACCAAACTGACAGTGGAAGAATTGAAGGCCTTTGTCCAACAACTTTTTAGTCTTCCGTGTGTCATCAGCCAAGCTCGGCA
AGTAAAGAATCTGCTAGATGATGTGGAAGAGTTTCATGAACGTGCTCAGGAGGCCATGATGGATGAAACCCCAGATTCTTCCAAACTCCA
GATGTTGATAGATATGGGCTCTAGTCTCTATGTGGAACTCCCTGAATTACCACGACTGAAGCAAGAGCTACAACAGGCTCGGTGGTTGGA
CGAAGTAAGACTGACCTTATCAGATCCGCAACAAGTCACTTTGGATGTCATGAAGAAGCTGATAGACTCTGGGGTAGGGTTGGCACCCCA
CCATGCTGTGGAGAAAGCAATGGCTGAACTACAGGAGCTCCTTACAGTCTCTGAACGATGGGAAGAAAAGGCTAAGGTCTGCCTACAGGC
AAGACCGAGGCACAGTGTGGCAAGTTTAGAAAGCATTGTGAATGAAGCCAAGAACATTCCAGCCTTTCTACCCAATGTGTTGTCCTTGAA
AGAAGCCTTACAAAAGGCTCGAGAATGGACCGCTAAAGTGGAAGCTATTCAGAGTGGCAGCAATTACGCTTATTTGGAGCAGCTTGAGAG
CTTGTCTGCGAAAGGACGCCCTATTCCTGTGCGTCTTGAAGCACTGCCGCAAGTGGAATCACAGGTAGCAGCAGCACGGGCATGGAGAGA
ACGGACTGGGCGGACGTTTCTTAAGAAGAATTCTAGCCATACATTGTTACAGGTGCTGAGCCCCCGGACCGACATTGGTGTATATGGGAG
TGGCAAAAATAGGAGGAAAAAAGTAAAAGAACTAATAGAAAAAGAAAAAGAAAAGGATCTGGACCTGGAGCCTCTGAGTGATCTGGAGGA
AGGATTGGAGGAAACCAGAGATACAGCCATGGTGGTGGCAGTTTTCAAAGAACGGGAGCAAAAAGAGATTGAAGCCATGCATTCTCTCAG
AGCAGCCAACCTAGCCAAGATGACAATGGTGGACCGCATAGAAGAAGTAAAATTTTGCATTTGCCGCAAGACAGCCAGTGGGTTTATGCT
ACAGTGTGAGCTCTGCAAAGACTGGTTCCATAACAGCTGTGTTCCTCTTCCTAAATCAAGTTCCCAAAAAAAAGGATCCAGCTGGCAAGC
TAAAGAAGTAAAATTCCTTTGCCCTCTTTGTATGCGGTCTCGAAGGCCCAGGCTAGAGACTATTCTGTCACTCCTGGTATCCCTTCAGAA
GTTGCCCGTACGGTTGCCTGAAGGAGAGGCCCTGCAGTGTTTGACAGAACGTGCTATGAGTTGGCAAGATAGAGCGCGGCAGGCTCTAGC
CACAGATGAACTATCCTCTGCCCTGGCCAAACTATCTGTGTTGAGCCAGCGTATGGTGGAACAGGCGGCTCGAGAAAAAACTGAAAAGAT
CATCAGTGCAGAACTCCAAAAAGCAGCTGCCAATCCAGACTTACAGGGACACTTACCTAGTTTCCAGCAGTCTGCTTTTAACCGGGTGGT
GAGCAGTGTGTCATCTTCTCCTCGACAAACAATGGACTATGATGATGAAGAAACAGACTCTGATGAAGACATTCGAGAGACATATGGCTA
CGACATGAAGGACACAGCCAGTGTGAAGTCCTCTAGTAGTCTTGAACCCAATCTTTTTTGTGATGAAGAGATTCCCATCAAATCCGAGGA
GGTGGTGACCCACATGTGGACAGCACCTTCATTTTGTGCAGAGCATGCTTATTCTTCTGCTTCTAAGAGTTGTTCTCAAGGTTCTAGCAC
CCCAAGGAAACAACCTCGGAAGAGCCCTTTGGTGCCCCGAAGTTTGGAACCTCCAGTGCTGGAGTTGTCACCTGGAGCTAAGGCACAACT
GGAAGAACTTATGATGGTTGGAGATCTCCTGGAAGTATCTCTGGACGAGACTCAACACATATGGCGGATTTTGCAGGCCACACACCCACC
CTCTGAAGACAGATTCTTGCATATCATGGAGGATGACAGCATGGAAGAGAAACCACTAAAAGTGAAAGGAAAGGACTCTTCAGAGAAGAA
ACGGAAACGGAAGCTAGAAAAGGTAGAGCAACTTTTTGGAGAAGGAAAACAGAAGTCCAAGGAGTTAAAGAAAATGGACAAACCTAGAAA
GAAGAAATTAAAATTAGGTGCAGACAAATCAAAGGAGCTGAATAAACTGGCCAAGAAACTAGCAAAAGAAGAAGAGAGAAAGAAAAAGAA
GGAGAAGGCTGCTGCAGCCAAAGTTGAACTTGTGAAAGAGAGCACTGAAAAGAAAAGAGAGAAAAAGGTGCTGGACATCCCCTCAAAGTA
TGACTGGTCAGGAGCAGAGGAGTCTGATGATGAGAATGCTGTGTGCGCAGCACAGAACTGCCAAAGGCCCTGCAAGGACAAGGTAGACTG
GGTACAATGTGATGGTGGCTGTGATGAGTGGTTTCATCAAGTTTGTGTGGGTGTATCTCCAGAAATGGCTGAAAATGAAGATTACATCTG
TATAAACTGTGCAAAGAAGCAGGGGCCAGTTAGCCCAGGTCCAGCACCACCTCCTTCCTTCATAATGAGCTACAAACTACCAATGGAGGA
TCTTAAAGAGACCAGTTAGCAGATGCTTGGTTAGTTTGGGACATGGGGGGACATGGACCACATTGAGACCTTAGTCATCAAGTAGAGTGG
TTTATATCCACTTGGAATGTTGCTTCCAAAGATGAATGGCCTTCAGAGAAAGTCCCCTTAGTGCTGGCTTCCTCTTTGCATGGACTCTGT
GGGTTACATTCTCTATCAACATATCTATGCAGAGGGTGTCTTCTTTGGTACAACAGCCAATATTTCATGTCTCCTTTGAGTGTGGTTTAC
TGCATTAAGGCCAGATGCTTAATTGAGCTCTAGGGTGGCTGGTTAGTATTAATACATTGGTGTGCTAACAGGGCATATAGGATGTGGCTT
TTGTCCAGCTGATAGTAGTTAGAGGCTTACAACTTAGGAGCAGCACCAACTGAAGGTGCTAATTGCTTGGATCTCCTTCATTGGGATAGT
TGGAGAGGGATTGGAGTACCACTTTCCTTCCACTGTTACCTGGTACTTAATGCCCTAAAGATACAACTAGGAGTAACAGGGCCAAAGTTA
TTTCTGTTAGACGTCAAGGAATGGTATCACAGTCTATTGACCTCAGCGATTTGTGCTTGTTTGTGCTAGAAGAACATCCCAAATAGGAGA
ACCTCTCACAAGCTGGGGCAGGTCACCTTATCTTTGTAAGATGAGGATATCATCTAGATCAGAAATCTGACTAGATTGGATTCTGAGGAG
AAGAACCTACTACAAGGCAAGGAGCCGTTTTTTGGCTTTGAAAAGTCTTGCTGTCTTGGGTCTACATTTTAGGGAAGAGCAGGTACATGG
ATCCAGGCTTCTGCCAAAAAAAAAAAGAGAAGAAGATGACGATGATGACCAGTCGTACTATCTTACTGAGCCACAGTGATGCATGCTTTT
CGGGGAAAACTTCATTCACAAGTATTCCAGACACCAGGCTTCAGGCATGGCCATGAGCAAGACCAGCAAATAACAGCTTTTTGCCTTGCA
GCCCTGACCCCAATGTCTGCTGTTTCCAACACTGGTGATTTCTAACTACGGCCCACAGCAGATGCTGTTGAATAACACCATGGCTTCATC
AGAGGATGTGGGGTTGTAGTACCTCTGGGTGATGAAGTTGTTTTAGTAAATCCATTTTTAAAAAAAAAAAAGGACTTGTTTTTACTTTTT
TCTAAATGTCTCTGACTACTGACTGTTCTATACATAGATTATTTTTCCTTTTTTAATATACATATATGAATATATAAATATATATATTTA
CTGTTACCAGCAGCATATGACAGAGTTTCAACATCAAAAATCCATTTGGGGGCTTGCTTTTTCTTTTTTGCTTTAAAAAAAAAAATCCCA
TTCCTTCTTTGTAGTACAAGGAGTTAGCACTCCCTCCTCCATCCCAGCCTGACCAGATCTTCCATTTTGCTTTTGTTCATATAGATAATT
ATATGTCCTTTGTGTGTTGGGACTTGTCCCTGTCTGTTGGGAAACTTGGTCTCACTCTAGTCTGTGCTGGCTCTTTTTTCTTTTGTGTGT
GAATGTTTGAAACTATGGTGCTGTGTCCTCTTCCCTCCTGTTGTGTTCTCTGTTCTTCTTAAGGTATTAGGTAAGCTGTATGTAAACTCT
TATTAGAAGGGGACTAATTTTTTTTTAAAGGACAAAAAAAAAAATGACTAAAAATAGTGTTTTGTCATCACTGTCTGGTGTCTTTATTTT
GGTTTAAAAAAATCTGTGGTTTGACTTAAATTCATCAGTTTTCCTTTTAAAGGGGGGATTGGGGTGGACCTAGCAACAGCTTATAGTTTC
CTCTTCCCTTTTTGCCCCAGTCTCTTTTAAAGAACTGTCTTCTAGTAACTAGAAGTGAAATGTACTGTCCAGTTACAGTTTGAGTGGGTA
TGAGATTTAACTCAAAAGGAATCTTACAAAAAAAAAGATGTTTTCTTATAAAATCCAATTTCTGTAAATGTTTTCTCTGAAGTTCATACT
ACCTACTTTTTATTCATTCTTAATACTGTATAACATTTTGAGTGTTTTGACTTGTTCAGAGGTTTGTTAGTGTTGCTGTGCATATGTCTT
GAGGTCTCATCTGAAGTAAGTTTGTGTATGATCGAAGATTTCAATGGATATTGCAAGGTAACTAATTAACTGATTTCATAAGTTTTCGTT
TTGCCAAGCTAACGATTATCAATTAAGAATTTCCTCTGGTTGATGTTATACAAGAAAGCACAATATTTTTTGCCTGTTGATCTTCTTTGT
AACAGTCTTCAGATATTTGTGGGTTAAAAATTGAATGTAATTTTAAGTGACAGATGCCTGGAATACATTTAAAATTTTTATTTTTCCTTC
CTAATCATCCATTAACTATTCCACTATCAGTGGAGAGTCATGAGGATGCTGAGAAAGTATGAATAGCTTCCTGTCACCTTCTGACGTTTT
GAAACTTAAATATGTCTTTTCGTTGATACTGTGGGATTTTCTGTATTTACTTGACAGTCATGGAGGATTTGGTATGACTTGACCACAGGT
TTAGACCAAGGCTGAGAAGAACAGAAGGGAGAAATTAATGGCAAAACAAAAAATACACAAATCTGCGGTTTTGGAATTAATGAAACAAGA
TTCATCTATTTAAAGAAATGTTGGTGTTCTAATACAAAGCATTATTTTCACTTAGAGAAAATTACTTACTTGCTCCCTTCTGTATTGTAA
TATTTTGTATTAAGACATGATTTAAAATGTCTTTCTACCCTTATCTCCTCTAAACTGCAACTGAAGTTGCAATTCTTCATCATTAGTATT
TTAACTCTGGCAAAGGTTATAGAAAGAAAAATGGAAATATGGTAGGCCTGTGGTATTCTTAAAAGCTAAGTCATTAGAACTATGCAGATC
CCCAAGTTTAAAAGTACAAATACAGCACCAGTAGTTAGCTTTCTAGCTGGGGGAGAAGACAGGAGATTTTTCTTCCACAGATGTTTATTT
TGCTTCCTGATAGGTACTGCAGCAAAGCCATGTTGATGTGTAGATGCATGACTTCCTCACTAAGCTGCTGCACACCAGCTTTGCCTGCAT
GATTCAAATTTGTGCCTCAGTAAAATTATAAATTATTGCATGTCATACCTTGAATAATGGAAACGGCAAACATTAAACCTGTGATTACCC
ATAATGTACTTTAATAATAAAAAACATGGCAGCCAGGTGCAGTAGAGTGCACCTGTGGTCAGGAGGCTGAAGTGGGAAGATTGCTTCAAC
CTGTGAGTTTGAGTCCCGCCTGGTCAACAGCGAGACCCCATGTGTCTGTCTGTCTCTCTCTTTTTTTAAAGGACAGAGGCTAAGCTGTAA
GGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGTGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCT
GCGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCAGGCTGAGCTGTAAGGTTAG
CATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCTAGCAGGTGCCCACAAAATGTCTTTTTGAATTTCTTAATTTTTGGGTTCTGG
ATGCAATTCGTGCACGCCAAGAAACTACTTGCTTGTCAGTATTTTAATTCTGTAGTACATGTGTGTGAATATCAGCCAGTACTTACAGTA
GGAGGATGAACAGAAAAACTGAGAAGACCTGTCTTTCAAAAGATGGGTTTATCCACTTTTTAAGGGAAAAAGTGACAGTTTGGCATGGGA
TTTGAAAAGTGGAAATTGTGGAAAAATTGAGCTGTTGAAGTCCCACATATAACCAGATTTAATAAAGCTTCACATGTGAATTAGCTCCAT
ATGTGTGTAGAAGGTTGCTTTTATAGCAGGTCCTTAAGTACTCCTTTTGAAATTCCTCCTTTTTTTTTAAGTCATACCATTACTTCTTTG
GATATGAATGTCCCAAGTGGTATCTCCTACTGTAGTATGAGGAAGAATGGCTGTTAATGTATTTTTTGAATTTTGGTCTTGTCTTGGCCT
GGATCATATCCAGTCACCACTATGCAACAAATGATGTGCACTGGGCAAGGATATGATGGGTTATGAAAGCTGTATCTTGTTTGTTTTTTC
TTTTGCAGTACTCCAAGTGGTCTAAACAGGAATGTCTTGTAAAACCTCAAGACTCCCTATTGATTATTCCCTTACATATTTATTTACAAT
TTATCAGGGTAATTGGTGGTGCCTTATGAAAAGTATAACTCGATTTCTTGATCTTTGAGCATGTTTTGTGTTTCTTGTGTTTTCTAAAAG
AATATTAGATATGGTTAATTGCATTACATCTAAAAGATTTAAAAAATTGTGTGTATGCTCAGGTTCCCCACACCCATACCCACCCTAACC
CCTGTCATTTACATTGGTGGCAACTTTAAATGGTAACCAAGCAAAAGTACATTTTGATAATGAGTATTGATAATCCTGAGGAAAACTAGT
GAGTATATGGGAGCCACCTTTGACCTGTGCCAAAGCAGTTTCTAATTTCATTTGCTAACTATAAAATAAAGAACTGAGCCAAAATAATTT
GATCAGTGGTGTGATTAGCCTATTATCATTGCTGAGAATAGTGTTTTTGGAGTGTGAAGTGATTCCTGAAGATTTCACCTGCCTTCTGTT
TCCAGCAAGAATCCAGTGATGACCAACACATTTCCTCACTTTTGGTTCTTGAGAAGTTTATCCCTTTGCAACAAACCATTAATAGGGAAA
ACAAGGAAATGCTTTCCCTTTCTCTTTGGCTTCTTAAAGCTCACAACCAATTCAGACCCCAAGTTACTTCAGAGAAGCAAATGGCACCTT
TTCCCCATTGCCAAGGATCCCAGCTTATGCAGATATGAAGGACGGATCATTTCTGAAAATGTTAAGACTCTGCTTGCAGTGGACTTGGCC
TCAGTTTCATGAAATGTGTAACTCTGTATGTGTATGTTAGGAGGAGGGTTGGTTGAAAGAGCGGGGGCAGGGAGGGGAATCTGATTACCT
CTTGGGAAATAATTTTCTTGCCAACAAAAAGATACACTTGAAGTTTCTTAAGGTGGCAAGTCCATTAAAAAAAAAAATTGTGTTGGACCC
TCCCAGTTTAGATCAAGTATTTCTTGGGGGTCTTGCTATTGTGGTTGATACCAATAAATGGAAGATCCAGAATATTTTCATTTAAAGCTC
AACCATTAATTGGAACATGGTGAAACATTGTACACATTGTAAAAGTAGGGAACAGTACAAAAGAATGGAATCAAATACTATATTATGTGA

>99334_99334_4_WNK1-KDM5A_WNK1_chr12_939326_ENST00000537687_KDM5A_chr12_432947_ENST00000399788_length(amino acids)=1520AA_BP=486
MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA
AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS
QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL
KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKT
YLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDE
SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCP
MQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQL
LLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPE
LPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSVASLESIVNE
AKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLEALPQVESQVAAARAWRERTGRTFLKKNSSHTL
LQVLSPRTDIGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVAVFKEREQKEIEAMHSLRAANLAKMTMVDRIEE
VKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKGSSWQAKEVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLT
ERAMSWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPRQTMDYDD
EETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSL
EPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSMEEKPLKVKGKDSSEKKRKRKLEKVEQLFGEG
KQKSKELKKMDKPRKKKLKLGADKSKELNKLAKKLAKEEERKKKKEKAAAAKVELVKESTEKKREKKVLDIPSKYDWSGAEESDDENAVC

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Fusion Gene PPI Analysis for WNK1-KDM5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WNK1-KDM5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WNK1-KDM5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource