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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WNK1-PRMT8 (FusionGDB2 ID:99337)

Fusion Gene Summary for WNK1-PRMT8

check button Fusion gene summary
Fusion gene informationFusion gene name: WNK1-PRMT8
Fusion gene ID: 99337
HgeneTgene
Gene symbol

WNK1

PRMT8

Gene ID

65125

56341

Gene nameWNK lysine deficient protein kinase 1protein arginine methyltransferase 8
SynonymsHSAN2|HSN2|KDP|PPP1R167|PRKWNK1|PSK|p65HRMT1L3|HRMT1L4
Cytomap

12p13.33

12p13.32

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase WNK1WNK lysine deficient protein kinase 1 isoformerythrocyte 65 kDa proteinprostate-derived sterile 20-like kinaseprotein kinase with no lysine 1protein phosphatase 1, regulatory subunit 167serine/threonine-protein kiprotein arginine N-methyltransferase 8HMT1 hnRNP methyltransferase-like 3arginine methyltransferase 8heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4protein arginine N-methyltransferase 4
Modification date2020032720200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000315939, ENST00000340908, 
ENST00000530271, ENST00000535572, 
ENST00000537687, ENST00000447667, 
ENST00000540360, ENST00000574564, 
ENST00000261252, ENST00000382622, 
ENST00000452611, 
Fusion gene scores* DoF score23 X 19 X 15=65555 X 4 X 4=80
# samples 375
** MAII scorelog2(37/6555*10)=-4.14699860459281
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WNK1 [Title/Abstract] AND PRMT8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWNK1(971436)-PRMT8(3649772), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWNK1

GO:0006468

protein phosphorylation

10660600

HgeneWNK1

GO:0010923

negative regulation of phosphatase activity

19389623

HgeneWNK1

GO:0023016

signal transduction by trans-phosphorylation

16669787

HgeneWNK1

GO:0035556

intracellular signal transduction

10660600

TgenePRMT8

GO:0006479

protein methylation

17925405

TgenePRMT8

GO:0016571

histone methylation

16051612|17925405

TgenePRMT8

GO:0018216

peptidyl-arginine methylation

16051612|18320585

TgenePRMT8

GO:0019919

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

16051612|17925405

TgenePRMT8

GO:0051260

protein homooligomerization

26876602


check buttonFusion gene breakpoints across WNK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRMT8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A18T-01AWNK1chr12

971436

-PRMT8chr12

3649772

+
ChimerDB4BRCATCGA-BH-A18T-01AWNK1chr12

971436

+PRMT8chr12

3649772

+


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Fusion Gene ORF analysis for WNK1-PRMT8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000315939ENST00000261252WNK1chr12

971436

+PRMT8chr12

3649772

+
5CDS-3UTRENST00000340908ENST00000261252WNK1chr12

971436

+PRMT8chr12

3649772

+
5CDS-3UTRENST00000530271ENST00000261252WNK1chr12

971436

+PRMT8chr12

3649772

+
5CDS-3UTRENST00000535572ENST00000261252WNK1chr12

971436

+PRMT8chr12

3649772

+
5CDS-3UTRENST00000537687ENST00000261252WNK1chr12

971436

+PRMT8chr12

3649772

+
In-frameENST00000315939ENST00000382622WNK1chr12

971436

+PRMT8chr12

3649772

+
In-frameENST00000315939ENST00000452611WNK1chr12

971436

+PRMT8chr12

3649772

+
In-frameENST00000340908ENST00000382622WNK1chr12

971436

+PRMT8chr12

3649772

+
In-frameENST00000340908ENST00000452611WNK1chr12

971436

+PRMT8chr12

3649772

+
In-frameENST00000530271ENST00000382622WNK1chr12

971436

+PRMT8chr12

3649772

+
In-frameENST00000530271ENST00000452611WNK1chr12

971436

+PRMT8chr12

3649772

+
In-frameENST00000535572ENST00000382622WNK1chr12

971436

+PRMT8chr12

3649772

+
In-frameENST00000535572ENST00000452611WNK1chr12

971436

+PRMT8chr12

3649772

+
In-frameENST00000537687ENST00000382622WNK1chr12

971436

+PRMT8chr12

3649772

+
In-frameENST00000537687ENST00000452611WNK1chr12

971436

+PRMT8chr12

3649772

+
intron-3CDSENST00000447667ENST00000382622WNK1chr12

971436

+PRMT8chr12

3649772

+
intron-3CDSENST00000447667ENST00000452611WNK1chr12

971436

+PRMT8chr12

3649772

+
intron-3CDSENST00000540360ENST00000382622WNK1chr12

971436

+PRMT8chr12

3649772

+
intron-3CDSENST00000540360ENST00000452611WNK1chr12

971436

+PRMT8chr12

3649772

+
intron-3CDSENST00000574564ENST00000382622WNK1chr12

971436

+PRMT8chr12

3649772

+
intron-3CDSENST00000574564ENST00000452611WNK1chr12

971436

+PRMT8chr12

3649772

+
intron-3UTRENST00000447667ENST00000261252WNK1chr12

971436

+PRMT8chr12

3649772

+
intron-3UTRENST00000540360ENST00000261252WNK1chr12

971436

+PRMT8chr12

3649772

+
intron-3UTRENST00000574564ENST00000261252WNK1chr12

971436

+PRMT8chr12

3649772

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535572WNK1chr12971436+ENST00000452611PRMT8chr123649772+4222311282642211132
ENST00000535572WNK1chr12971436+ENST00000382622PRMT8chr123649772+5013311282642211131
ENST00000537687WNK1chr12971436+ENST00000452611PRMT8chr123649772+3892278249638911132
ENST00000537687WNK1chr12971436+ENST00000382622PRMT8chr123649772+4683278249638911131
ENST00000315939WNK1chr12971436+ENST00000452611PRMT8chr123649772+3892278249638911132
ENST00000315939WNK1chr12971436+ENST00000382622PRMT8chr123649772+4683278249638911131
ENST00000530271WNK1chr12971436+ENST00000452611PRMT8chr123649772+32492139032481082
ENST00000530271WNK1chr12971436+ENST00000382622PRMT8chr123649772+40402139032481082
ENST00000340908WNK1chr12971436+ENST00000452611PRMT8chr123649772+202891802027675
ENST00000340908WNK1chr12971436+ENST00000382622PRMT8chr123649772+281991802027675

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535572ENST00000452611WNK1chr12971436+PRMT8chr123649772+0.0032888930.99671113
ENST00000535572ENST00000382622WNK1chr12971436+PRMT8chr123649772+0.0026449410.9973551
ENST00000537687ENST00000452611WNK1chr12971436+PRMT8chr123649772+0.0023174270.9976826
ENST00000537687ENST00000382622WNK1chr12971436+PRMT8chr123649772+0.0018301050.9981699
ENST00000315939ENST00000452611WNK1chr12971436+PRMT8chr123649772+0.0023174270.9976826
ENST00000315939ENST00000382622WNK1chr12971436+PRMT8chr123649772+0.0018301050.9981699
ENST00000530271ENST00000452611WNK1chr12971436+PRMT8chr123649772+0.0007933690.9992066
ENST00000530271ENST00000382622WNK1chr12971436+PRMT8chr123649772+0.0006357540.9993643
ENST00000340908ENST00000452611WNK1chr12971436+PRMT8chr123649772+0.0011660070.99883395
ENST00000340908ENST00000382622WNK1chr12971436+PRMT8chr123649772+0.0008397530.9991603

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Fusion Genomic Features for WNK1-PRMT8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WNK1chr12971436+PRMT8chr123649771+0.0001168930.99988306
WNK1chr12971436+PRMT8chr123649771+0.0001168930.99988306

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for WNK1-PRMT8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:971436/chr12:3649772)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWNK1chr12:971436chr12:3649772ENST00000315939+828221_4797132383.0DomainProtein kinase
HgeneWNK1chr12:971436chr12:3649772ENST00000537687+828221_4797132643.0DomainProtein kinase
HgeneWNK1chr12:971436chr12:3649772ENST00000315939+828301_3047132383.0Nucleotide bindingATP
HgeneWNK1chr12:971436chr12:3649772ENST00000340908+525301_3043061976.0Nucleotide bindingATP
HgeneWNK1chr12:971436chr12:3649772ENST00000537687+828301_3047132643.0Nucleotide bindingATP
HgeneWNK1chr12:971436chr12:3649772ENST00000315939+828488_5557132383.0RegionAutoinhibitory domain
HgeneWNK1chr12:971436chr12:3649772ENST00000537687+828488_5557132643.0RegionAutoinhibitory domain
TgenePRMT8chr12:971436chr12:3649772ENST0000038262201073_39425395.0DomainSAM-dependent MTase PRMT-type
TgenePRMT8chr12:971436chr12:3649772ENST0000045261101073_39416386.0DomainSAM-dependent MTase PRMT-type
TgenePRMT8chr12:971436chr12:3649772ENST0000038262201029_4225395.0MotifSH3-binding 1
TgenePRMT8chr12:971436chr12:3649772ENST0000038262201053_5825395.0MotifSH3-binding 2
TgenePRMT8chr12:971436chr12:3649772ENST0000045261101029_4216386.0MotifSH3-binding 1
TgenePRMT8chr12:971436chr12:3649772ENST0000045261101053_5816386.0MotifSH3-binding 2
TgenePRMT8chr12:971436chr12:3649772ENST00000382622010119_12225395.0RegionS-adenosyl-L-methionine binding
TgenePRMT8chr12:971436chr12:3649772ENST00000452611010119_12216386.0RegionS-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWNK1chr12:971436chr12:3649772ENST00000340908+525221_4793061976.0DomainProtein kinase
HgeneWNK1chr12:971436chr12:3649772ENST00000574564+11221_4790435.0DomainProtein kinase
HgeneWNK1chr12:971436chr12:3649772ENST00000574564+11301_3040435.0Nucleotide bindingATP
HgeneWNK1chr12:971436chr12:3649772ENST00000340908+525488_5553061976.0RegionAutoinhibitory domain
HgeneWNK1chr12:971436chr12:3649772ENST00000574564+11488_5550435.0RegionAutoinhibitory domain


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Fusion Gene Sequence for WNK1-PRMT8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99337_99337_1_WNK1-PRMT8_WNK1_chr12_971436_ENST00000315939_PRMT8_chr12_3649772_ENST00000382622_length(transcript)=4683nt_BP=2782nt
CCGGCCCTTCGCCTCTGGGCGATGGGCGACCTGTGAGGCCGGTCCCCATCGCTGGGGGCGCGTGTGGGAGGAGGCGGCCGCCCGAGTGAC
CGGGAGCCGGGCCGCGGCCTTCCCTCGCCCGCCTCGGCCCCTCCCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGT
CCCGTGCTCGCGGTGCCGCCGCCCTCTGGGCCTAGCCCGCCCAGCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTC
GACTCGGTGCCGGCCCCTGGCCCTCCCCTCATGACTGCGGCGCCTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATG
CGGACCGTGCGGCGCTAACCCCCGTGGCTCAGCTCCCGAATCGCCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGC
CCCCGCCGCAGCTGGGCCCAGCGGTCCGCCTGTCCCTCGTTGCGGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCG
CCCGGCCGCGGTTCCCTGCAGACCTCTGCGCGGGCGGCTCGGCCCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTC
CAGCGAACCGACCATGTCTGGCGGCGCCGCAGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAA
GAATGGCTCCAGCTCCGATTCCTCCGTGGGGGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCG
CCGCCGCCACACTATGGACAAGGACAGCCGTGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTG
TGACTCCAATGCCACTGCACTGGAGCTTCCCGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCC
ACCGGAGCCCCACCGGGAAGAGACCGTGACCGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACA
GGCCGTCGCGGGCCCTGCCCCCTCGACTGTCCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGA
GGAGCCGCCGCCGGCGAGAAGTGGCAGCGGCGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGA
GCTGGAGACCAAGGCCGTGGGAATGTCTAACGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTA
CAAAGGTCTGGACACTGAAACCACCGTGGAAGTCGCCTGGTGTGAACTGCAGGATCGAAAATTAACAAAGTCTGAGAGGCAGAGATTTAA
AGAAGAAGCTGAAATGTTAAAAGGTCTTCAGCATCCCAATATTGTTAGATTTTATGATTCCTGGGAATCCACAGTAAAAGGAAAGAAGTG
CATTGTTTTGGTGACTGAACTTATGACGTCTGGAACACTTAAAACGTATCTGAAAAGGTTTAAAGTGATGAAGATCAAAGTTCTAAGAAG
CTGGTGCCGTCAGATCCTTAAAGGTCTTCAGTTTCTTCATACTCGAACTCCACCTATCATTCACCGCGATCTTAAATGTGACAACATCTT
TATCACCGGCCCTACTGGCTCAGTCAAGATTGGAGACCTCGGTCTGGCAACCCTGAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTAC
CCCAGAGTTCATGGCCCCTGAGATGTATGAGGAGAAATATGATGAATCCGTTGACGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGC
TACATCTGAATATCCTTACTCGGAGTGCCAAAATGCTGCACAGATCTACCGTCGCGTGACCAGTGGGGTGAAGCCAGCCAGTTTTGACAA
AGTAGCAATTCCTGAAGTGAAGGAAATTATTGAAGGATGCATACGACAAAACAAAGATGAAAGATATTCCATCAAAGACCTTTTGAACCA
TGCCTTCTTCCAAGAGGAAACAGGAGTACGGGTAGAATTAGCAGAAGAAGATGATGGAGAAAAAATAGCCATAAAATTATGGCTACGTAT
TGAAGATATTAAGAAATTAAAGGGAAAATACAAAGATAATGAAGCTATTGAGTTTTCTTTTGATTTAGAGAGAGATGTCCCAGAAGATGT
TGCACAAGAAATGGTAGAGTCTGGGTATGTCTGTGAAGGTGATCACAAGACCATGGCTAAAGCTATCAAAGACAGAGTATCATTAATTAA
GAGGAAACGAGAGCAGCGGCAGTTGGTACGGGAGGAGCAAGAAAAAAAAAAGCAGGAAGAGAGCAGTCTCAAACAGCAGGTAGAACAATC
CAGTGCTTCCCAGACAGGAATCAAGCAGCTCCCTTCTGCTAGCACCGGCATACCTACTGCTTCTACCACTTCAGCTTCAGTTTCTACACA
AGTAGAACCTGAAGAACCTGAGGCAGATCAACATCAACAACTACAGTACCAGCAACCCAGTATATCTGTGTTATCTGATGGGACGGTTGA
CAGTGGTCAGGGATCCTCTGTCTTCACAGAATCTCGAGTGAGCAGCCAACAGACAGTTTCATATGGTTCCCAACATGAACAGGCACATTC
TACAGGCACAGTCCCAGGGCATATACCTTCTACTGTCCAAGCACAGTCTCAGCCCCATGGGGTATATCCACCCTCAAGTGTGGTGAACAG
CCCCCCCTCCCAGCCCCCCCAGCCCGTCGTCCCTGCTAAGCCCGTGCAATGCGTCCATCATGTGTCCACTCAACCCAGCTGCCCAGGACG
GGGCAAGATGTCCAAGCTGCTGAACCCAGAGGAGATGACCTCGAGAGATTATTACTTCGACTCCTATGCCCACTTTGGGATCCACGAGGA
AATGCTGAAGGATGAGGTGCGGACTCTCACTTACCGGAACTCCATGTACCACAACAAGCACGTGTTCAAGGACAAAGTGGTACTGGATGT
GGGGAGTGGTACTGGGATCCTTTCCATGTTCGCTGCCAAGGCAGGGGCCAAGAAGGTGTTTGGGATCGAATGCTCCAGTATTTCTGACTA
CTCAGAGAAGATCATTAAGGCCAACCACTTGGACAACATCATCACCATATTTAAGGGTAAAGTGGAAGAGGTGGAGCTGCCTGTGGAGAA
GGTGGACATCATCATCAGCGAGTGGATGGGCTACTGTCTGTTCTATGAGTCCATGCTCAACACGGTGATCTTTGCCAGGGACAAGTGGCT
GAAACCTGGAGGGCTTATGTTTCCAGACCGGGCAGCTTTGTACGTGGTAGCGATTGAAGACAGACAGTACAAGGACTTCAAAATCCACTG
GTGGGAGAATGTCTATGGCTTTGACATGACCTGCATCCGGGACGTGGCCATGAAGGAGCCTCTAGTGGACATCGTGGATCCAAAGCAAGT
GGTGACCAATGCCTGTTTGATAAAGGAGGTGGACATTTACACAGTGAAGACGGAAGAGCTATCGTTCACATCTGCATTCTGCCTGCAGAT
ACAGCGCAACGACTACGTCCACGCCCTGGTCACCTATTTTAATATTGAATTTACCAAGTGCCACAAGAAAATGGGGTTTTCCACAGCCCC
TGATGCTCCCTACACCCACTGGAAGCAGACCGTCTTCTACTTGGAAGATTACCTCACTGTCCGGAGGGGGGAGGAAATCTACGGGACCAT
ATCCATGAAGCCAAATGCCAAAAATGTGCGAGACCTCGATTTCACAGTAGACTTGGATTTTAAGGGACAGCTGTGTGAAACATCTGTATC
TAATGACTACAAAATGCGTTAGCACACGTGGGAAGCTGCAGAGAGCAACGAGAAAAGGAACTCTCACCTCGATCTGCCGTGCCGTCCCAA
AGAATACCGTTTGCAGGACTACACACTTGAAAACCAGAGTTTTCAACTCTGCCTTGAAGATTGGTGAACTCCCCAGGGCTCCCGTGGGCT
CTGCCACTGGACAGAAGGCCTCCAGCTCCTCCGCTCTGCCCTGGTAGCCCTTCACGAAGGCTTTGTGTTGCCAACAAAGAGCGACCTGGC
GTGCTGTGGCTGGGCCCCGAGGGTGGAAACGTATTCGCGTCTCCCCGTCTCCTCCTTAACTGTGACTCTCCGGGTCTTCTGAGTTTTGCA
TGCTGCGGGTGTCTAGGACAGATTGCTTCCACTAGAACCTGGAGACATAGCATCTTTGATAGCATAAGCCAGATTATCTGTGTGTGCGGT
GGTGTGCGTGTGCGTGCATGTGTGAATGTGAGCAGCATAGTTGATATTTACCCACAAACACCTGTATATGCGTGCATATACAACCAAGTG
GGTAGACCTAGGTGTTCTCTCAGAGGGGTGTGTGTGTGTGTGCGTGCGCGTGTGCCTAGAATATATATTACTCTCAGAGGAGATTCTGTT
GCTTTTGAATAGGAATTTGTTTTGTGATTAGTTCGCCCCTTCCCCACCCCTTACCAGATGTTAAGCAGCTATGAAACATTCTCTGTACTA
GTTCTGGTCTCCTTTTGACTGGACTGTGGCTCTGAACCTTGAGCATAGTACCACGGACTCCGTGGGCGCTCAATAAACACACATGAGAAC

>99337_99337_1_WNK1-PRMT8_WNK1_chr12_971436_ENST00000315939_PRMT8_chr12_3649772_ENST00000382622_length(amino acids)=1131AA_BP=762
MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA
AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS
QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL
KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKT
YLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDE
SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAE
EDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEK
KKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSS
QQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSR
DYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIIT
IFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDV
AMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLE

--------------------------------------------------------------
>99337_99337_2_WNK1-PRMT8_WNK1_chr12_971436_ENST00000315939_PRMT8_chr12_3649772_ENST00000452611_length(transcript)=3892nt_BP=2782nt
CCGGCCCTTCGCCTCTGGGCGATGGGCGACCTGTGAGGCCGGTCCCCATCGCTGGGGGCGCGTGTGGGAGGAGGCGGCCGCCCGAGTGAC
CGGGAGCCGGGCCGCGGCCTTCCCTCGCCCGCCTCGGCCCCTCCCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGT
CCCGTGCTCGCGGTGCCGCCGCCCTCTGGGCCTAGCCCGCCCAGCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTC
GACTCGGTGCCGGCCCCTGGCCCTCCCCTCATGACTGCGGCGCCTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATG
CGGACCGTGCGGCGCTAACCCCCGTGGCTCAGCTCCCGAATCGCCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGC
CCCCGCCGCAGCTGGGCCCAGCGGTCCGCCTGTCCCTCGTTGCGGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCG
CCCGGCCGCGGTTCCCTGCAGACCTCTGCGCGGGCGGCTCGGCCCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTC
CAGCGAACCGACCATGTCTGGCGGCGCCGCAGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAA
GAATGGCTCCAGCTCCGATTCCTCCGTGGGGGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCG
CCGCCGCCACACTATGGACAAGGACAGCCGTGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTG
TGACTCCAATGCCACTGCACTGGAGCTTCCCGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCC
ACCGGAGCCCCACCGGGAAGAGACCGTGACCGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACA
GGCCGTCGCGGGCCCTGCCCCCTCGACTGTCCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGA
GGAGCCGCCGCCGGCGAGAAGTGGCAGCGGCGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGA
GCTGGAGACCAAGGCCGTGGGAATGTCTAACGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTA
CAAAGGTCTGGACACTGAAACCACCGTGGAAGTCGCCTGGTGTGAACTGCAGGATCGAAAATTAACAAAGTCTGAGAGGCAGAGATTTAA
AGAAGAAGCTGAAATGTTAAAAGGTCTTCAGCATCCCAATATTGTTAGATTTTATGATTCCTGGGAATCCACAGTAAAAGGAAAGAAGTG
CATTGTTTTGGTGACTGAACTTATGACGTCTGGAACACTTAAAACGTATCTGAAAAGGTTTAAAGTGATGAAGATCAAAGTTCTAAGAAG
CTGGTGCCGTCAGATCCTTAAAGGTCTTCAGTTTCTTCATACTCGAACTCCACCTATCATTCACCGCGATCTTAAATGTGACAACATCTT
TATCACCGGCCCTACTGGCTCAGTCAAGATTGGAGACCTCGGTCTGGCAACCCTGAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTAC
CCCAGAGTTCATGGCCCCTGAGATGTATGAGGAGAAATATGATGAATCCGTTGACGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGC
TACATCTGAATATCCTTACTCGGAGTGCCAAAATGCTGCACAGATCTACCGTCGCGTGACCAGTGGGGTGAAGCCAGCCAGTTTTGACAA
AGTAGCAATTCCTGAAGTGAAGGAAATTATTGAAGGATGCATACGACAAAACAAAGATGAAAGATATTCCATCAAAGACCTTTTGAACCA
TGCCTTCTTCCAAGAGGAAACAGGAGTACGGGTAGAATTAGCAGAAGAAGATGATGGAGAAAAAATAGCCATAAAATTATGGCTACGTAT
TGAAGATATTAAGAAATTAAAGGGAAAATACAAAGATAATGAAGCTATTGAGTTTTCTTTTGATTTAGAGAGAGATGTCCCAGAAGATGT
TGCACAAGAAATGGTAGAGTCTGGGTATGTCTGTGAAGGTGATCACAAGACCATGGCTAAAGCTATCAAAGACAGAGTATCATTAATTAA
GAGGAAACGAGAGCAGCGGCAGTTGGTACGGGAGGAGCAAGAAAAAAAAAAGCAGGAAGAGAGCAGTCTCAAACAGCAGGTAGAACAATC
CAGTGCTTCCCAGACAGGAATCAAGCAGCTCCCTTCTGCTAGCACCGGCATACCTACTGCTTCTACCACTTCAGCTTCAGTTTCTACACA
AGTAGAACCTGAAGAACCTGAGGCAGATCAACATCAACAACTACAGTACCAGCAACCCAGTATATCTGTGTTATCTGATGGGACGGTTGA
CAGTGGTCAGGGATCCTCTGTCTTCACAGAATCTCGAGTGAGCAGCCAACAGACAGTTTCATATGGTTCCCAACATGAACAGGCACATTC
TACAGGCACAGTCCCAGGGCATATACCTTCTACTGTCCAAGCACAGTCTCAGCCCCATGGGGTATATCCACCCTCAAGTGTGGTGAACAG
CCCCCCCTCCCAGCCCCCCCAGCCCGTCGTCCCTGCTAAGCCCGTGCAATGCGTCCATCATGTGTCCACTCAACCCAGCTGCCCAGGACG
GGGCAAGATGTCCAAGCTGCTGAACCCAGAGGAGATGACCTCGAGAGATTATTACTTCGACTCCTATGCCCACTTTGGGATCCACGAGGA
AATGCTGAAGGATGAGGTGCGGACTCTCACTTACCGGAACTCCATGTACCACAACAAGCACGTGTTCAAGGACAAAGTGGTACTGGATGT
GGGGAGTGGTACTGGGATCCTTTCCATGTTCGCTGCCAAGGCAGGGGCCAAGAAGGTGTTTGGGATCGAATGCTCCAGTATTTCTGACTA
CTCAGAGAAGATCATTAAGGCCAACCACTTGGACAACATCATCACCATATTTAAGGGTAAAGTGGAAGAGGTGGAGCTGCCTGTGGAGAA
GGTGGACATCATCATCAGCGAGTGGATGGGCTACTGTCTGTTCTATGAGTCCATGCTCAACACGGTGATCTTTGCCAGGGACAAGTGGCT
GAAACCTGGAGGGCTTATGTTTCCAGACCGGGCAGCTTTGTACGTGGTAGCGATTGAAGACAGACAGTACAAGGACTTCAAAATCCACTG
GTGGGAGAATGTCTATGGCTTTGACATGACCTGCATCCGGGACGTGGCCATGAAGGAGCCTCTAGTGGACATCGTGGATCCAAAGCAAGT
GGTGACCAATGCCTGTTTGATAAAGGAGGTGGACATTTACACAGTGAAGACGGAAGAGCTATCGTTCACATCTGCATTCTGCCTGCAGAT
ACAGCGCAACGACTACGTCCACGCCCTGGTCACCTATTTTAATATTGAATTTACCAAGTGCCACAAGAAAATGGGGTTTTCCACAGCCCC
TGATGCTCCCTACACCCACTGGAAGCAGACCGTCTTCTACTTGGAAGATTACCTCACTGTCCGGAGGGGGGAGGAAATCTACGGGACCAT
ATCCATGAAGCCAAATGCCAAAAATGTGCGAGACCTCGATTTCACAGTAGACTTGGATTTTAAGGGACAGCTGTGTGAAACATCTGTATC

>99337_99337_2_WNK1-PRMT8_WNK1_chr12_971436_ENST00000315939_PRMT8_chr12_3649772_ENST00000452611_length(amino acids)=1132AA_BP=762
MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA
AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS
QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL
KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKT
YLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDE
SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAE
EDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEK
KKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSS
QQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSR
DYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIIT
IFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDV
AMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLE

--------------------------------------------------------------
>99337_99337_3_WNK1-PRMT8_WNK1_chr12_971436_ENST00000340908_PRMT8_chr12_3649772_ENST00000382622_length(transcript)=2819nt_BP=918nt
ATGGATATTAAAAAGAAAGATTTTTGCTCAGTATTTGTCATCATAAATTCTCATTGCTGCTGCTGCCCTCAAAAGGATTGTATAAATGAG
GGGGTGAAGCCAGCCAGTTTTGACAAAGTAGCAATTCCTGAAGTGAAGGAAATTATTGAAGGATGCATACGACAAAACAAAGATGAAAGA
TATTCCATCAAAGACCTTTTGAACCATGCCTTCTTCCAAGAGGAAACAGGAGTACGGGTAGAATTAGCAGAAGAAGATGATGGAGAAAAA
ATAGCCATAAAATTATGGCTACGTATTGAAGATATTAAGAAATTAAAGGGAAAATACAAAGATAATGAAGCTATTGAGTTTTCTTTTGAT
TTAGAGAGAGATGTCCCAGAAGATGTTGCACAAGAAATGGTAGAGTCTGGGTATGTCTGTGAAGGTGATCACAAGACCATGGCTAAAGCT
ATCAAAGACAGAGTATCATTAATTAAGAGGAAACGAGAGCAGCGGCAGTTGGTACGGGAGGAGCAAGAAAAAAAAAAGCAGGAAGAGAGC
AGTCTCAAACAGCAGGTAGAACAATCCAGTGCTTCCCAGACAGGAATCAAGCAGCTCCCTTCTGCTAGCACCGGCATACCTACTGCTTCT
ACCACTTCAGCTTCAGTTTCTACACAAGTAGAACCTGAAGAACCTGAGGCAGATCAACATCAACAACTACAGTACCAGCAACCCAGTATA
TCTGTGTTATCTGATGGGACGGTTGACAGTGGTCAGGGATCCTCTGTCTTCACAGAATCTCGAGTGAGCAGCCAACAGACAGTTTCATAT
GGTTCCCAACATGAACAGGCACATTCTACAGGCACAGTCCCAGGGCATATACCTTCTACTGTCCAAGCACAGTCTCAGCCCCATGGGGTA
TATCCACCCTCAAGTGTGGTGAACAGCCCCCCCTCCCAGCCCCCCCAGCCCGTCGTCCCTGCTAAGCCCGTGCAATGCGTCCATCATGTG
TCCACTCAACCCAGCTGCCCAGGACGGGGCAAGATGTCCAAGCTGCTGAACCCAGAGGAGATGACCTCGAGAGATTATTACTTCGACTCC
TATGCCCACTTTGGGATCCACGAGGAAATGCTGAAGGATGAGGTGCGGACTCTCACTTACCGGAACTCCATGTACCACAACAAGCACGTG
TTCAAGGACAAAGTGGTACTGGATGTGGGGAGTGGTACTGGGATCCTTTCCATGTTCGCTGCCAAGGCAGGGGCCAAGAAGGTGTTTGGG
ATCGAATGCTCCAGTATTTCTGACTACTCAGAGAAGATCATTAAGGCCAACCACTTGGACAACATCATCACCATATTTAAGGGTAAAGTG
GAAGAGGTGGAGCTGCCTGTGGAGAAGGTGGACATCATCATCAGCGAGTGGATGGGCTACTGTCTGTTCTATGAGTCCATGCTCAACACG
GTGATCTTTGCCAGGGACAAGTGGCTGAAACCTGGAGGGCTTATGTTTCCAGACCGGGCAGCTTTGTACGTGGTAGCGATTGAAGACAGA
CAGTACAAGGACTTCAAAATCCACTGGTGGGAGAATGTCTATGGCTTTGACATGACCTGCATCCGGGACGTGGCCATGAAGGAGCCTCTA
GTGGACATCGTGGATCCAAAGCAAGTGGTGACCAATGCCTGTTTGATAAAGGAGGTGGACATTTACACAGTGAAGACGGAAGAGCTATCG
TTCACATCTGCATTCTGCCTGCAGATACAGCGCAACGACTACGTCCACGCCCTGGTCACCTATTTTAATATTGAATTTACCAAGTGCCAC
AAGAAAATGGGGTTTTCCACAGCCCCTGATGCTCCCTACACCCACTGGAAGCAGACCGTCTTCTACTTGGAAGATTACCTCACTGTCCGG
AGGGGGGAGGAAATCTACGGGACCATATCCATGAAGCCAAATGCCAAAAATGTGCGAGACCTCGATTTCACAGTAGACTTGGATTTTAAG
GGACAGCTGTGTGAAACATCTGTATCTAATGACTACAAAATGCGTTAGCACACGTGGGAAGCTGCAGAGAGCAACGAGAAAAGGAACTCT
CACCTCGATCTGCCGTGCCGTCCCAAAGAATACCGTTTGCAGGACTACACACTTGAAAACCAGAGTTTTCAACTCTGCCTTGAAGATTGG
TGAACTCCCCAGGGCTCCCGTGGGCTCTGCCACTGGACAGAAGGCCTCCAGCTCCTCCGCTCTGCCCTGGTAGCCCTTCACGAAGGCTTT
GTGTTGCCAACAAAGAGCGACCTGGCGTGCTGTGGCTGGGCCCCGAGGGTGGAAACGTATTCGCGTCTCCCCGTCTCCTCCTTAACTGTG
ACTCTCCGGGTCTTCTGAGTTTTGCATGCTGCGGGTGTCTAGGACAGATTGCTTCCACTAGAACCTGGAGACATAGCATCTTTGATAGCA
TAAGCCAGATTATCTGTGTGTGCGGTGGTGTGCGTGTGCGTGCATGTGTGAATGTGAGCAGCATAGTTGATATTTACCCACAAACACCTG
TATATGCGTGCATATACAACCAAGTGGGTAGACCTAGGTGTTCTCTCAGAGGGGTGTGTGTGTGTGTGCGTGCGCGTGTGCCTAGAATAT
ATATTACTCTCAGAGGAGATTCTGTTGCTTTTGAATAGGAATTTGTTTTGTGATTAGTTCGCCCCTTCCCCACCCCTTACCAGATGTTAA
GCAGCTATGAAACATTCTCTGTACTAGTTCTGGTCTCCTTTTGACTGGACTGTGGCTCTGAACCTTGAGCATAGTACCACGGACTCCGTG

>99337_99337_3_WNK1-PRMT8_WNK1_chr12_971436_ENST00000340908_PRMT8_chr12_3649772_ENST00000382622_length(amino acids)=675AA_BP=306
MDIKKKDFCSVFVIINSHCCCCPQKDCINEGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAEEDDGEK
IAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEKKKQEES
SLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVSY
GSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDS
YAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKV
EEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPL
VDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVR

--------------------------------------------------------------
>99337_99337_4_WNK1-PRMT8_WNK1_chr12_971436_ENST00000340908_PRMT8_chr12_3649772_ENST00000452611_length(transcript)=2028nt_BP=918nt
ATGGATATTAAAAAGAAAGATTTTTGCTCAGTATTTGTCATCATAAATTCTCATTGCTGCTGCTGCCCTCAAAAGGATTGTATAAATGAG
GGGGTGAAGCCAGCCAGTTTTGACAAAGTAGCAATTCCTGAAGTGAAGGAAATTATTGAAGGATGCATACGACAAAACAAAGATGAAAGA
TATTCCATCAAAGACCTTTTGAACCATGCCTTCTTCCAAGAGGAAACAGGAGTACGGGTAGAATTAGCAGAAGAAGATGATGGAGAAAAA
ATAGCCATAAAATTATGGCTACGTATTGAAGATATTAAGAAATTAAAGGGAAAATACAAAGATAATGAAGCTATTGAGTTTTCTTTTGAT
TTAGAGAGAGATGTCCCAGAAGATGTTGCACAAGAAATGGTAGAGTCTGGGTATGTCTGTGAAGGTGATCACAAGACCATGGCTAAAGCT
ATCAAAGACAGAGTATCATTAATTAAGAGGAAACGAGAGCAGCGGCAGTTGGTACGGGAGGAGCAAGAAAAAAAAAAGCAGGAAGAGAGC
AGTCTCAAACAGCAGGTAGAACAATCCAGTGCTTCCCAGACAGGAATCAAGCAGCTCCCTTCTGCTAGCACCGGCATACCTACTGCTTCT
ACCACTTCAGCTTCAGTTTCTACACAAGTAGAACCTGAAGAACCTGAGGCAGATCAACATCAACAACTACAGTACCAGCAACCCAGTATA
TCTGTGTTATCTGATGGGACGGTTGACAGTGGTCAGGGATCCTCTGTCTTCACAGAATCTCGAGTGAGCAGCCAACAGACAGTTTCATAT
GGTTCCCAACATGAACAGGCACATTCTACAGGCACAGTCCCAGGGCATATACCTTCTACTGTCCAAGCACAGTCTCAGCCCCATGGGGTA
TATCCACCCTCAAGTGTGGTGAACAGCCCCCCCTCCCAGCCCCCCCAGCCCGTCGTCCCTGCTAAGCCCGTGCAATGCGTCCATCATGTG
TCCACTCAACCCAGCTGCCCAGGACGGGGCAAGATGTCCAAGCTGCTGAACCCAGAGGAGATGACCTCGAGAGATTATTACTTCGACTCC
TATGCCCACTTTGGGATCCACGAGGAAATGCTGAAGGATGAGGTGCGGACTCTCACTTACCGGAACTCCATGTACCACAACAAGCACGTG
TTCAAGGACAAAGTGGTACTGGATGTGGGGAGTGGTACTGGGATCCTTTCCATGTTCGCTGCCAAGGCAGGGGCCAAGAAGGTGTTTGGG
ATCGAATGCTCCAGTATTTCTGACTACTCAGAGAAGATCATTAAGGCCAACCACTTGGACAACATCATCACCATATTTAAGGGTAAAGTG
GAAGAGGTGGAGCTGCCTGTGGAGAAGGTGGACATCATCATCAGCGAGTGGATGGGCTACTGTCTGTTCTATGAGTCCATGCTCAACACG
GTGATCTTTGCCAGGGACAAGTGGCTGAAACCTGGAGGGCTTATGTTTCCAGACCGGGCAGCTTTGTACGTGGTAGCGATTGAAGACAGA
CAGTACAAGGACTTCAAAATCCACTGGTGGGAGAATGTCTATGGCTTTGACATGACCTGCATCCGGGACGTGGCCATGAAGGAGCCTCTA
GTGGACATCGTGGATCCAAAGCAAGTGGTGACCAATGCCTGTTTGATAAAGGAGGTGGACATTTACACAGTGAAGACGGAAGAGCTATCG
TTCACATCTGCATTCTGCCTGCAGATACAGCGCAACGACTACGTCCACGCCCTGGTCACCTATTTTAATATTGAATTTACCAAGTGCCAC
AAGAAAATGGGGTTTTCCACAGCCCCTGATGCTCCCTACACCCACTGGAAGCAGACCGTCTTCTACTTGGAAGATTACCTCACTGTCCGG
AGGGGGGAGGAAATCTACGGGACCATATCCATGAAGCCAAATGCCAAAAATGTGCGAGACCTCGATTTCACAGTAGACTTGGATTTTAAG

>99337_99337_4_WNK1-PRMT8_WNK1_chr12_971436_ENST00000340908_PRMT8_chr12_3649772_ENST00000452611_length(amino acids)=675AA_BP=306
MDIKKKDFCSVFVIINSHCCCCPQKDCINEGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAEEDDGEK
IAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEKKKQEES
SLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVSY
GSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDS
YAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKV
EEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPL
VDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVR

--------------------------------------------------------------
>99337_99337_5_WNK1-PRMT8_WNK1_chr12_971436_ENST00000530271_PRMT8_chr12_3649772_ENST00000382622_length(transcript)=4040nt_BP=2139nt
ATGTCTGGCGGCGCCGCAGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAAGAATGGCTCCAGC
TCCGATTCCTCCGTGGGGGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCGCCGCCGCCACACT
ATGGACAAGGACAGCCGTGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTGTGACTCCAATGCC
ACTGCACTGGAGCTTCCCGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCCACCGGAGCCCCAC
CGGGAAGAGACCGTGACCGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACAGGCCGTCGCGGGC
CCTGCCCCCTCGACTGTCCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGAGGAGCCGCCGCCG
GCGAGAAGTGGCAGCGGCGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGAGCTGGAGACCAAG
GCCGTGGGAATGTCTAACGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTACAAAGGTCTGGAC
ACTGAAACCACCGTGGAAGTCGCCTGGTGTGAACTGCAGGATCGAAAATTAACAAAGTCTGAGAGGCAGAGATTTAAAGAAGAAGCTGAA
ATGTTAAAAGGTCTTCAGCATCCCAATATTGTTAGATTTTATGATTCCTGGGAATCCACAGTAAAAGGAAAGAAGTGCATTGTTTTGGTG
ACTGAACTTATGACGTCTGGAACACTTAAAACGTATCTGAAAAGGTTTAAAGTGATGAAGATCAAAGTTCTAAGAAGCTGGTGCCGTCAG
ATCCTTAAAGGTCTTCAGTTTCTTCATACTCGAACTCCACCTATCATTCACCGCGATCTTAAATGTGACAACATCTTTATCACCGGCCCT
ACTGGCTCAGTCAAGATTGGAGACCTCGGTCTGGCAACCCTGAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTACCCCAGAGTTCATG
GCCCCTGAGATGTATGAGGAGAAATATGATGAATCCGTTGACGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGCTACATCTGAATAT
CCTTACTCGGAGTGCCAAAATGCTGCACAGATCTACCGTCGCGTGACCAGTGGGGTGAAGCCAGCCAGTTTTGACAAAGTAGCAATTCCT
GAAGTGAAGGAAATTATTGAAGGATGCATACGACAAAACAAAGATGAAAGATATTCCATCAAAGACCTTTTGAACCATGCCTTCTTCCAA
GAGGAAACAGGAGTACGGGTAGAATTAGCAGAAGAAGATGATGGAGAAAAAATAGCCATAAAATTATGGCTACGTATTGAAGATATTAAG
AAATTAAAGGGAAAATACAAAGATAATGAAGCTATTGAGTTTTCTTTTGATTTAGAGAGAGATGTCCCAGAAGATGTTGCACAAGAAATG
GTAGAGTCTGGGTATGTCTGTGAAGGTGATCACAAGACCATGGCTAAAGCTATCAAAGACAGAGTATCATTAATTAAGAGGAAACGAGAG
CAGCGGCAGTTGGTACGGGAGGAGCAAGAAAAAAAAAAGCAGGAAGAGAGCAGTCTCAAACAGCAGGTAGAACAATCCAGTGCTTCCCAG
ACAGGAATCAAGCAGCTCCCTTCTGCTAGCACCGGCATACCTACTGCTTCTACCACTTCAGCTTCAGTTTCTACACAAGTAGAACCTGAA
GAACCTGAGGCAGATCAACATCAACAACTACAGTACCAGCAACCCAGTATATCTGTGTTATCTGATGGGACGGTTGACAGTGGTCAGGGA
TCCTCTGTCTTCACAGAATCTCGAGTGAGCAGCCAACAGACAGTTTCATATGGTTCCCAACATGAACAGGCACATTCTACAGGCACAGTC
CCAGGGCATATACCTTCTACTGTCCAAGCACAGTCTCAGCCCCATGGGGTATATCCACCCTCAAGTGTGGTGAACAGCCCCCCCTCCCAG
CCCCCCCAGCCCGTCGTCCCTGCTAAGCCCGTGCAATGCGTCCATCATGTGTCCACTCAACCCAGCTGCCCAGGACGGGGCAAGATGTCC
AAGCTGCTGAACCCAGAGGAGATGACCTCGAGAGATTATTACTTCGACTCCTATGCCCACTTTGGGATCCACGAGGAAATGCTGAAGGAT
GAGGTGCGGACTCTCACTTACCGGAACTCCATGTACCACAACAAGCACGTGTTCAAGGACAAAGTGGTACTGGATGTGGGGAGTGGTACT
GGGATCCTTTCCATGTTCGCTGCCAAGGCAGGGGCCAAGAAGGTGTTTGGGATCGAATGCTCCAGTATTTCTGACTACTCAGAGAAGATC
ATTAAGGCCAACCACTTGGACAACATCATCACCATATTTAAGGGTAAAGTGGAAGAGGTGGAGCTGCCTGTGGAGAAGGTGGACATCATC
ATCAGCGAGTGGATGGGCTACTGTCTGTTCTATGAGTCCATGCTCAACACGGTGATCTTTGCCAGGGACAAGTGGCTGAAACCTGGAGGG
CTTATGTTTCCAGACCGGGCAGCTTTGTACGTGGTAGCGATTGAAGACAGACAGTACAAGGACTTCAAAATCCACTGGTGGGAGAATGTC
TATGGCTTTGACATGACCTGCATCCGGGACGTGGCCATGAAGGAGCCTCTAGTGGACATCGTGGATCCAAAGCAAGTGGTGACCAATGCC
TGTTTGATAAAGGAGGTGGACATTTACACAGTGAAGACGGAAGAGCTATCGTTCACATCTGCATTCTGCCTGCAGATACAGCGCAACGAC
TACGTCCACGCCCTGGTCACCTATTTTAATATTGAATTTACCAAGTGCCACAAGAAAATGGGGTTTTCCACAGCCCCTGATGCTCCCTAC
ACCCACTGGAAGCAGACCGTCTTCTACTTGGAAGATTACCTCACTGTCCGGAGGGGGGAGGAAATCTACGGGACCATATCCATGAAGCCA
AATGCCAAAAATGTGCGAGACCTCGATTTCACAGTAGACTTGGATTTTAAGGGACAGCTGTGTGAAACATCTGTATCTAATGACTACAAA
ATGCGTTAGCACACGTGGGAAGCTGCAGAGAGCAACGAGAAAAGGAACTCTCACCTCGATCTGCCGTGCCGTCCCAAAGAATACCGTTTG
CAGGACTACACACTTGAAAACCAGAGTTTTCAACTCTGCCTTGAAGATTGGTGAACTCCCCAGGGCTCCCGTGGGCTCTGCCACTGGACA
GAAGGCCTCCAGCTCCTCCGCTCTGCCCTGGTAGCCCTTCACGAAGGCTTTGTGTTGCCAACAAAGAGCGACCTGGCGTGCTGTGGCTGG
GCCCCGAGGGTGGAAACGTATTCGCGTCTCCCCGTCTCCTCCTTAACTGTGACTCTCCGGGTCTTCTGAGTTTTGCATGCTGCGGGTGTC
TAGGACAGATTGCTTCCACTAGAACCTGGAGACATAGCATCTTTGATAGCATAAGCCAGATTATCTGTGTGTGCGGTGGTGTGCGTGTGC
GTGCATGTGTGAATGTGAGCAGCATAGTTGATATTTACCCACAAACACCTGTATATGCGTGCATATACAACCAAGTGGGTAGACCTAGGT
GTTCTCTCAGAGGGGTGTGTGTGTGTGTGCGTGCGCGTGTGCCTAGAATATATATTACTCTCAGAGGAGATTCTGTTGCTTTTGAATAGG
AATTTGTTTTGTGATTAGTTCGCCCCTTCCCCACCCCTTACCAGATGTTAAGCAGCTATGAAACATTCTCTGTACTAGTTCTGGTCTCCT

>99337_99337_5_WNK1-PRMT8_WNK1_chr12_971436_ENST00000530271_PRMT8_chr12_3649772_ENST00000382622_length(amino acids)=1082AA_BP=713
MSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGAAAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNA
TALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATSQVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPP
ARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAE
MLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGP
TGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIP
EVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAEEDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEM
VESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEKKKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPE
EPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVVNSPPSQ
PPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGT
GILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGG
LMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRND
YVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYK

--------------------------------------------------------------
>99337_99337_6_WNK1-PRMT8_WNK1_chr12_971436_ENST00000530271_PRMT8_chr12_3649772_ENST00000452611_length(transcript)=3249nt_BP=2139nt
ATGTCTGGCGGCGCCGCAGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAAGAATGGCTCCAGC
TCCGATTCCTCCGTGGGGGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCGCCGCCGCCACACT
ATGGACAAGGACAGCCGTGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTGTGACTCCAATGCC
ACTGCACTGGAGCTTCCCGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCCACCGGAGCCCCAC
CGGGAAGAGACCGTGACCGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACAGGCCGTCGCGGGC
CCTGCCCCCTCGACTGTCCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGAGGAGCCGCCGCCG
GCGAGAAGTGGCAGCGGCGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGAGCTGGAGACCAAG
GCCGTGGGAATGTCTAACGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTACAAAGGTCTGGAC
ACTGAAACCACCGTGGAAGTCGCCTGGTGTGAACTGCAGGATCGAAAATTAACAAAGTCTGAGAGGCAGAGATTTAAAGAAGAAGCTGAA
ATGTTAAAAGGTCTTCAGCATCCCAATATTGTTAGATTTTATGATTCCTGGGAATCCACAGTAAAAGGAAAGAAGTGCATTGTTTTGGTG
ACTGAACTTATGACGTCTGGAACACTTAAAACGTATCTGAAAAGGTTTAAAGTGATGAAGATCAAAGTTCTAAGAAGCTGGTGCCGTCAG
ATCCTTAAAGGTCTTCAGTTTCTTCATACTCGAACTCCACCTATCATTCACCGCGATCTTAAATGTGACAACATCTTTATCACCGGCCCT
ACTGGCTCAGTCAAGATTGGAGACCTCGGTCTGGCAACCCTGAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTACCCCAGAGTTCATG
GCCCCTGAGATGTATGAGGAGAAATATGATGAATCCGTTGACGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGCTACATCTGAATAT
CCTTACTCGGAGTGCCAAAATGCTGCACAGATCTACCGTCGCGTGACCAGTGGGGTGAAGCCAGCCAGTTTTGACAAAGTAGCAATTCCT
GAAGTGAAGGAAATTATTGAAGGATGCATACGACAAAACAAAGATGAAAGATATTCCATCAAAGACCTTTTGAACCATGCCTTCTTCCAA
GAGGAAACAGGAGTACGGGTAGAATTAGCAGAAGAAGATGATGGAGAAAAAATAGCCATAAAATTATGGCTACGTATTGAAGATATTAAG
AAATTAAAGGGAAAATACAAAGATAATGAAGCTATTGAGTTTTCTTTTGATTTAGAGAGAGATGTCCCAGAAGATGTTGCACAAGAAATG
GTAGAGTCTGGGTATGTCTGTGAAGGTGATCACAAGACCATGGCTAAAGCTATCAAAGACAGAGTATCATTAATTAAGAGGAAACGAGAG
CAGCGGCAGTTGGTACGGGAGGAGCAAGAAAAAAAAAAGCAGGAAGAGAGCAGTCTCAAACAGCAGGTAGAACAATCCAGTGCTTCCCAG
ACAGGAATCAAGCAGCTCCCTTCTGCTAGCACCGGCATACCTACTGCTTCTACCACTTCAGCTTCAGTTTCTACACAAGTAGAACCTGAA
GAACCTGAGGCAGATCAACATCAACAACTACAGTACCAGCAACCCAGTATATCTGTGTTATCTGATGGGACGGTTGACAGTGGTCAGGGA
TCCTCTGTCTTCACAGAATCTCGAGTGAGCAGCCAACAGACAGTTTCATATGGTTCCCAACATGAACAGGCACATTCTACAGGCACAGTC
CCAGGGCATATACCTTCTACTGTCCAAGCACAGTCTCAGCCCCATGGGGTATATCCACCCTCAAGTGTGGTGAACAGCCCCCCCTCCCAG
CCCCCCCAGCCCGTCGTCCCTGCTAAGCCCGTGCAATGCGTCCATCATGTGTCCACTCAACCCAGCTGCCCAGGACGGGGCAAGATGTCC
AAGCTGCTGAACCCAGAGGAGATGACCTCGAGAGATTATTACTTCGACTCCTATGCCCACTTTGGGATCCACGAGGAAATGCTGAAGGAT
GAGGTGCGGACTCTCACTTACCGGAACTCCATGTACCACAACAAGCACGTGTTCAAGGACAAAGTGGTACTGGATGTGGGGAGTGGTACT
GGGATCCTTTCCATGTTCGCTGCCAAGGCAGGGGCCAAGAAGGTGTTTGGGATCGAATGCTCCAGTATTTCTGACTACTCAGAGAAGATC
ATTAAGGCCAACCACTTGGACAACATCATCACCATATTTAAGGGTAAAGTGGAAGAGGTGGAGCTGCCTGTGGAGAAGGTGGACATCATC
ATCAGCGAGTGGATGGGCTACTGTCTGTTCTATGAGTCCATGCTCAACACGGTGATCTTTGCCAGGGACAAGTGGCTGAAACCTGGAGGG
CTTATGTTTCCAGACCGGGCAGCTTTGTACGTGGTAGCGATTGAAGACAGACAGTACAAGGACTTCAAAATCCACTGGTGGGAGAATGTC
TATGGCTTTGACATGACCTGCATCCGGGACGTGGCCATGAAGGAGCCTCTAGTGGACATCGTGGATCCAAAGCAAGTGGTGACCAATGCC
TGTTTGATAAAGGAGGTGGACATTTACACAGTGAAGACGGAAGAGCTATCGTTCACATCTGCATTCTGCCTGCAGATACAGCGCAACGAC
TACGTCCACGCCCTGGTCACCTATTTTAATATTGAATTTACCAAGTGCCACAAGAAAATGGGGTTTTCCACAGCCCCTGATGCTCCCTAC
ACCCACTGGAAGCAGACCGTCTTCTACTTGGAAGATTACCTCACTGTCCGGAGGGGGGAGGAAATCTACGGGACCATATCCATGAAGCCA
AATGCCAAAAATGTGCGAGACCTCGATTTCACAGTAGACTTGGATTTTAAGGGACAGCTGTGTGAAACATCTGTATCTAATGACTACAAA

>99337_99337_6_WNK1-PRMT8_WNK1_chr12_971436_ENST00000530271_PRMT8_chr12_3649772_ENST00000452611_length(amino acids)=1082AA_BP=713
MSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGAAAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNA
TALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATSQVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPP
ARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAE
MLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGP
TGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIP
EVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAEEDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEM
VESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEKKKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPE
EPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVVNSPPSQ
PPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGT
GILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGG
LMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRND
YVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYK

--------------------------------------------------------------
>99337_99337_7_WNK1-PRMT8_WNK1_chr12_971436_ENST00000535572_PRMT8_chr12_3649772_ENST00000382622_length(transcript)=5013nt_BP=3112nt
ATTTAGCGCGGAGAGTTTCCCGGGTGGACGCGGCTCCTCTCTCGGCCACTCCGCACCCCCATCTTCGGTGACAGAAGGCGCCTGGTGGGG
GTGGCTGCTCTTTTCTCTCCCTGTTCCCCCTCACCCAGTCCTCTAGGTCTCCTCTCCTCTTGCCTCAGAGAAGCAGCGGAGCTCGGGCCC
CGCGGTGAGCGGCCCTCCCCTCCCCGCCGTTCCCTCCTCCGTCAGCCCCCGGCACCGGCCCGGGAGGAGACGGGTTTGCCAGGCCTGGGG
CGGGCGGGGAGGCCTCGGGGAAGGGGGGGCCCGCTCCTCAGGCGCCGAGGCTCCGAGGCTCCGGCCCTTCGCCTCTGGGCGATGGGCGAC
CTGTGAGGCCGGTCCCCATCGCTGGGGGCGCGTGTGGGAGGAGGCGGCCGCCCGAGTGACCGGGAGCCGGGCCGCGGCCTTCCCTCGCCC
GCCTCGGCCCCTCCCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGTCCCGTGCTCGCGGTGCCGCCGCCCTCTGGG
CCTAGCCCGCCCAGCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTCGACTCGGTGCCGGCCCCTGGCCCTCCCCTC
ATGACTGCGGCGCCTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATGCGGACCGTGCGGCGCTAACCCCCGTGGCTC
AGCTCCCGAATCGCCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGCCCCCGCCGCAGCTGGGCCCAGCGGTCCGCC
TGTCCCTCGTTGCGGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCGCCCGGCCGCGGTTCCCTGCAGACCTCTGCG
CGGGCGGCTCGGCCCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTCCAGCGAACCGACCATGTCTGGCGGCGCCGC
AGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAAGAATGGCTCCAGCTCCGATTCCTCCGTGGG
GGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCGCCGCCGCCACACTATGGACAAGGACAGCCG
TGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTGTGACTCCAATGCCACTGCACTGGAGCTTCC
CGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCCACCGGAGCCCCACCGGGAAGAGACCGTGAC
CGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACAGGCCGTCGCGGGCCCTGCCCCCTCGACTGT
CCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGAGGAGCCGCCGCCGGCGAGAAGTGGCAGCGG
CGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGAGCTGGAGACCAAGGCCGTGGGAATGTCTAA
CGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTACAAAGGTCTGGACACTGAAACCACCGTGGA
AGTCGCCTGGTGTGAACTGCAGGATCGAAAATTAACAAAGTCTGAGAGGCAGAGATTTAAAGAAGAAGCTGAAATGTTAAAAGGTCTTCA
GCATCCCAATATTGTTAGATTTTATGATTCCTGGGAATCCACAGTAAAAGGAAAGAAGTGCATTGTTTTGGTGACTGAACTTATGACGTC
TGGAACACTTAAAACGTATCTGAAAAGGTTTAAAGTGATGAAGATCAAAGTTCTAAGAAGCTGGTGCCGTCAGATCCTTAAAGGTCTTCA
GTTTCTTCATACTCGAACTCCACCTATCATTCACCGCGATCTTAAATGTGACAACATCTTTATCACCGGCCCTACTGGCTCAGTCAAGAT
TGGAGACCTCGGTCTGGCAACCCTGAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTACCCCAGAGTTCATGGCCCCTGAGATGTATGA
GGAGAAATATGATGAATCCGTTGACGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGCTACATCTGAATATCCTTACTCGGAGTGCCA
AAATGCTGCACAGATCTACCGTCGCGTGACCAGTGGGGTGAAGCCAGCCAGTTTTGACAAAGTAGCAATTCCTGAAGTGAAGGAAATTAT
TGAAGGATGCATACGACAAAACAAAGATGAAAGATATTCCATCAAAGACCTTTTGAACCATGCCTTCTTCCAAGAGGAAACAGGAGTACG
GGTAGAATTAGCAGAAGAAGATGATGGAGAAAAAATAGCCATAAAATTATGGCTACGTATTGAAGATATTAAGAAATTAAAGGGAAAATA
CAAAGATAATGAAGCTATTGAGTTTTCTTTTGATTTAGAGAGAGATGTCCCAGAAGATGTTGCACAAGAAATGGTAGAGTCTGGGTATGT
CTGTGAAGGTGATCACAAGACCATGGCTAAAGCTATCAAAGACAGAGTATCATTAATTAAGAGGAAACGAGAGCAGCGGCAGTTGGTACG
GGAGGAGCAAGAAAAAAAAAAGCAGGAAGAGAGCAGTCTCAAACAGCAGGTAGAACAATCCAGTGCTTCCCAGACAGGAATCAAGCAGCT
CCCTTCTGCTAGCACCGGCATACCTACTGCTTCTACCACTTCAGCTTCAGTTTCTACACAAGTAGAACCTGAAGAACCTGAGGCAGATCA
ACATCAACAACTACAGTACCAGCAACCCAGTATATCTGTGTTATCTGATGGGACGGTTGACAGTGGTCAGGGATCCTCTGTCTTCACAGA
ATCTCGAGTGAGCAGCCAACAGACAGTTTCATATGGTTCCCAACATGAACAGGCACATTCTACAGGCACAGTCCCAGGGCATATACCTTC
TACTGTCCAAGCACAGTCTCAGCCCCATGGGGTATATCCACCCTCAAGTGTGGTGAACAGCCCCCCCTCCCAGCCCCCCCAGCCCGTCGT
CCCTGCTAAGCCCGTGCAATGCGTCCATCATGTGTCCACTCAACCCAGCTGCCCAGGACGGGGCAAGATGTCCAAGCTGCTGAACCCAGA
GGAGATGACCTCGAGAGATTATTACTTCGACTCCTATGCCCACTTTGGGATCCACGAGGAAATGCTGAAGGATGAGGTGCGGACTCTCAC
TTACCGGAACTCCATGTACCACAACAAGCACGTGTTCAAGGACAAAGTGGTACTGGATGTGGGGAGTGGTACTGGGATCCTTTCCATGTT
CGCTGCCAAGGCAGGGGCCAAGAAGGTGTTTGGGATCGAATGCTCCAGTATTTCTGACTACTCAGAGAAGATCATTAAGGCCAACCACTT
GGACAACATCATCACCATATTTAAGGGTAAAGTGGAAGAGGTGGAGCTGCCTGTGGAGAAGGTGGACATCATCATCAGCGAGTGGATGGG
CTACTGTCTGTTCTATGAGTCCATGCTCAACACGGTGATCTTTGCCAGGGACAAGTGGCTGAAACCTGGAGGGCTTATGTTTCCAGACCG
GGCAGCTTTGTACGTGGTAGCGATTGAAGACAGACAGTACAAGGACTTCAAAATCCACTGGTGGGAGAATGTCTATGGCTTTGACATGAC
CTGCATCCGGGACGTGGCCATGAAGGAGCCTCTAGTGGACATCGTGGATCCAAAGCAAGTGGTGACCAATGCCTGTTTGATAAAGGAGGT
GGACATTTACACAGTGAAGACGGAAGAGCTATCGTTCACATCTGCATTCTGCCTGCAGATACAGCGCAACGACTACGTCCACGCCCTGGT
CACCTATTTTAATATTGAATTTACCAAGTGCCACAAGAAAATGGGGTTTTCCACAGCCCCTGATGCTCCCTACACCCACTGGAAGCAGAC
CGTCTTCTACTTGGAAGATTACCTCACTGTCCGGAGGGGGGAGGAAATCTACGGGACCATATCCATGAAGCCAAATGCCAAAAATGTGCG
AGACCTCGATTTCACAGTAGACTTGGATTTTAAGGGACAGCTGTGTGAAACATCTGTATCTAATGACTACAAAATGCGTTAGCACACGTG
GGAAGCTGCAGAGAGCAACGAGAAAAGGAACTCTCACCTCGATCTGCCGTGCCGTCCCAAAGAATACCGTTTGCAGGACTACACACTTGA
AAACCAGAGTTTTCAACTCTGCCTTGAAGATTGGTGAACTCCCCAGGGCTCCCGTGGGCTCTGCCACTGGACAGAAGGCCTCCAGCTCCT
CCGCTCTGCCCTGGTAGCCCTTCACGAAGGCTTTGTGTTGCCAACAAAGAGCGACCTGGCGTGCTGTGGCTGGGCCCCGAGGGTGGAAAC
GTATTCGCGTCTCCCCGTCTCCTCCTTAACTGTGACTCTCCGGGTCTTCTGAGTTTTGCATGCTGCGGGTGTCTAGGACAGATTGCTTCC
ACTAGAACCTGGAGACATAGCATCTTTGATAGCATAAGCCAGATTATCTGTGTGTGCGGTGGTGTGCGTGTGCGTGCATGTGTGAATGTG
AGCAGCATAGTTGATATTTACCCACAAACACCTGTATATGCGTGCATATACAACCAAGTGGGTAGACCTAGGTGTTCTCTCAGAGGGGTG
TGTGTGTGTGTGCGTGCGCGTGTGCCTAGAATATATATTACTCTCAGAGGAGATTCTGTTGCTTTTGAATAGGAATTTGTTTTGTGATTA
GTTCGCCCCTTCCCCACCCCTTACCAGATGTTAAGCAGCTATGAAACATTCTCTGTACTAGTTCTGGTCTCCTTTTGACTGGACTGTGGC

>99337_99337_7_WNK1-PRMT8_WNK1_chr12_971436_ENST00000535572_PRMT8_chr12_3649772_ENST00000382622_length(amino acids)=1131AA_BP=762
MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA
AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS
QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL
KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKT
YLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDE
SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAE
EDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEK
KKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSS
QQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSR
DYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIIT
IFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDV
AMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLE

--------------------------------------------------------------
>99337_99337_8_WNK1-PRMT8_WNK1_chr12_971436_ENST00000535572_PRMT8_chr12_3649772_ENST00000452611_length(transcript)=4222nt_BP=3112nt
ATTTAGCGCGGAGAGTTTCCCGGGTGGACGCGGCTCCTCTCTCGGCCACTCCGCACCCCCATCTTCGGTGACAGAAGGCGCCTGGTGGGG
GTGGCTGCTCTTTTCTCTCCCTGTTCCCCCTCACCCAGTCCTCTAGGTCTCCTCTCCTCTTGCCTCAGAGAAGCAGCGGAGCTCGGGCCC
CGCGGTGAGCGGCCCTCCCCTCCCCGCCGTTCCCTCCTCCGTCAGCCCCCGGCACCGGCCCGGGAGGAGACGGGTTTGCCAGGCCTGGGG
CGGGCGGGGAGGCCTCGGGGAAGGGGGGGCCCGCTCCTCAGGCGCCGAGGCTCCGAGGCTCCGGCCCTTCGCCTCTGGGCGATGGGCGAC
CTGTGAGGCCGGTCCCCATCGCTGGGGGCGCGTGTGGGAGGAGGCGGCCGCCCGAGTGACCGGGAGCCGGGCCGCGGCCTTCCCTCGCCC
GCCTCGGCCCCTCCCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGTCCCGTGCTCGCGGTGCCGCCGCCCTCTGGG
CCTAGCCCGCCCAGCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTCGACTCGGTGCCGGCCCCTGGCCCTCCCCTC
ATGACTGCGGCGCCTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATGCGGACCGTGCGGCGCTAACCCCCGTGGCTC
AGCTCCCGAATCGCCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGCCCCCGCCGCAGCTGGGCCCAGCGGTCCGCC
TGTCCCTCGTTGCGGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCGCCCGGCCGCGGTTCCCTGCAGACCTCTGCG
CGGGCGGCTCGGCCCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTCCAGCGAACCGACCATGTCTGGCGGCGCCGC
AGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAAGAATGGCTCCAGCTCCGATTCCTCCGTGGG
GGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCGCCGCCGCCACACTATGGACAAGGACAGCCG
TGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTGTGACTCCAATGCCACTGCACTGGAGCTTCC
CGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCCACCGGAGCCCCACCGGGAAGAGACCGTGAC
CGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACAGGCCGTCGCGGGCCCTGCCCCCTCGACTGT
CCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGAGGAGCCGCCGCCGGCGAGAAGTGGCAGCGG
CGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGAGCTGGAGACCAAGGCCGTGGGAATGTCTAA
CGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTACAAAGGTCTGGACACTGAAACCACCGTGGA
AGTCGCCTGGTGTGAACTGCAGGATCGAAAATTAACAAAGTCTGAGAGGCAGAGATTTAAAGAAGAAGCTGAAATGTTAAAAGGTCTTCA
GCATCCCAATATTGTTAGATTTTATGATTCCTGGGAATCCACAGTAAAAGGAAAGAAGTGCATTGTTTTGGTGACTGAACTTATGACGTC
TGGAACACTTAAAACGTATCTGAAAAGGTTTAAAGTGATGAAGATCAAAGTTCTAAGAAGCTGGTGCCGTCAGATCCTTAAAGGTCTTCA
GTTTCTTCATACTCGAACTCCACCTATCATTCACCGCGATCTTAAATGTGACAACATCTTTATCACCGGCCCTACTGGCTCAGTCAAGAT
TGGAGACCTCGGTCTGGCAACCCTGAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTACCCCAGAGTTCATGGCCCCTGAGATGTATGA
GGAGAAATATGATGAATCCGTTGACGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGCTACATCTGAATATCCTTACTCGGAGTGCCA
AAATGCTGCACAGATCTACCGTCGCGTGACCAGTGGGGTGAAGCCAGCCAGTTTTGACAAAGTAGCAATTCCTGAAGTGAAGGAAATTAT
TGAAGGATGCATACGACAAAACAAAGATGAAAGATATTCCATCAAAGACCTTTTGAACCATGCCTTCTTCCAAGAGGAAACAGGAGTACG
GGTAGAATTAGCAGAAGAAGATGATGGAGAAAAAATAGCCATAAAATTATGGCTACGTATTGAAGATATTAAGAAATTAAAGGGAAAATA
CAAAGATAATGAAGCTATTGAGTTTTCTTTTGATTTAGAGAGAGATGTCCCAGAAGATGTTGCACAAGAAATGGTAGAGTCTGGGTATGT
CTGTGAAGGTGATCACAAGACCATGGCTAAAGCTATCAAAGACAGAGTATCATTAATTAAGAGGAAACGAGAGCAGCGGCAGTTGGTACG
GGAGGAGCAAGAAAAAAAAAAGCAGGAAGAGAGCAGTCTCAAACAGCAGGTAGAACAATCCAGTGCTTCCCAGACAGGAATCAAGCAGCT
CCCTTCTGCTAGCACCGGCATACCTACTGCTTCTACCACTTCAGCTTCAGTTTCTACACAAGTAGAACCTGAAGAACCTGAGGCAGATCA
ACATCAACAACTACAGTACCAGCAACCCAGTATATCTGTGTTATCTGATGGGACGGTTGACAGTGGTCAGGGATCCTCTGTCTTCACAGA
ATCTCGAGTGAGCAGCCAACAGACAGTTTCATATGGTTCCCAACATGAACAGGCACATTCTACAGGCACAGTCCCAGGGCATATACCTTC
TACTGTCCAAGCACAGTCTCAGCCCCATGGGGTATATCCACCCTCAAGTGTGGTGAACAGCCCCCCCTCCCAGCCCCCCCAGCCCGTCGT
CCCTGCTAAGCCCGTGCAATGCGTCCATCATGTGTCCACTCAACCCAGCTGCCCAGGACGGGGCAAGATGTCCAAGCTGCTGAACCCAGA
GGAGATGACCTCGAGAGATTATTACTTCGACTCCTATGCCCACTTTGGGATCCACGAGGAAATGCTGAAGGATGAGGTGCGGACTCTCAC
TTACCGGAACTCCATGTACCACAACAAGCACGTGTTCAAGGACAAAGTGGTACTGGATGTGGGGAGTGGTACTGGGATCCTTTCCATGTT
CGCTGCCAAGGCAGGGGCCAAGAAGGTGTTTGGGATCGAATGCTCCAGTATTTCTGACTACTCAGAGAAGATCATTAAGGCCAACCACTT
GGACAACATCATCACCATATTTAAGGGTAAAGTGGAAGAGGTGGAGCTGCCTGTGGAGAAGGTGGACATCATCATCAGCGAGTGGATGGG
CTACTGTCTGTTCTATGAGTCCATGCTCAACACGGTGATCTTTGCCAGGGACAAGTGGCTGAAACCTGGAGGGCTTATGTTTCCAGACCG
GGCAGCTTTGTACGTGGTAGCGATTGAAGACAGACAGTACAAGGACTTCAAAATCCACTGGTGGGAGAATGTCTATGGCTTTGACATGAC
CTGCATCCGGGACGTGGCCATGAAGGAGCCTCTAGTGGACATCGTGGATCCAAAGCAAGTGGTGACCAATGCCTGTTTGATAAAGGAGGT
GGACATTTACACAGTGAAGACGGAAGAGCTATCGTTCACATCTGCATTCTGCCTGCAGATACAGCGCAACGACTACGTCCACGCCCTGGT
CACCTATTTTAATATTGAATTTACCAAGTGCCACAAGAAAATGGGGTTTTCCACAGCCCCTGATGCTCCCTACACCCACTGGAAGCAGAC
CGTCTTCTACTTGGAAGATTACCTCACTGTCCGGAGGGGGGAGGAAATCTACGGGACCATATCCATGAAGCCAAATGCCAAAAATGTGCG

>99337_99337_8_WNK1-PRMT8_WNK1_chr12_971436_ENST00000535572_PRMT8_chr12_3649772_ENST00000452611_length(amino acids)=1132AA_BP=762
MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA
AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS
QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL
KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKT
YLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDE
SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAE
EDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEK
KKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSS
QQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSR
DYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIIT
IFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDV
AMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLE

--------------------------------------------------------------
>99337_99337_9_WNK1-PRMT8_WNK1_chr12_971436_ENST00000537687_PRMT8_chr12_3649772_ENST00000382622_length(transcript)=4683nt_BP=2782nt
CCGGCCCTTCGCCTCTGGGCGATGGGCGACCTGTGAGGCCGGTCCCCATCGCTGGGGGCGCGTGTGGGAGGAGGCGGCCGCCCGAGTGAC
CGGGAGCCGGGCCGCGGCCTTCCCTCGCCCGCCTCGGCCCCTCCCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGT
CCCGTGCTCGCGGTGCCGCCGCCCTCTGGGCCTAGCCCGCCCAGCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTC
GACTCGGTGCCGGCCCCTGGCCCTCCCCTCATGACTGCGGCGCCTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATG
CGGACCGTGCGGCGCTAACCCCCGTGGCTCAGCTCCCGAATCGCCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGC
CCCCGCCGCAGCTGGGCCCAGCGGTCCGCCTGTCCCTCGTTGCGGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCG
CCCGGCCGCGGTTCCCTGCAGACCTCTGCGCGGGCGGCTCGGCCCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTC
CAGCGAACCGACCATGTCTGGCGGCGCCGCAGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAA
GAATGGCTCCAGCTCCGATTCCTCCGTGGGGGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCG
CCGCCGCCACACTATGGACAAGGACAGCCGTGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTG
TGACTCCAATGCCACTGCACTGGAGCTTCCCGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCC
ACCGGAGCCCCACCGGGAAGAGACCGTGACCGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACA
GGCCGTCGCGGGCCCTGCCCCCTCGACTGTCCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGA
GGAGCCGCCGCCGGCGAGAAGTGGCAGCGGCGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGA
GCTGGAGACCAAGGCCGTGGGAATGTCTAACGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTA
CAAAGGTCTGGACACTGAAACCACCGTGGAAGTCGCCTGGTGTGAACTGCAGGATCGAAAATTAACAAAGTCTGAGAGGCAGAGATTTAA
AGAAGAAGCTGAAATGTTAAAAGGTCTTCAGCATCCCAATATTGTTAGATTTTATGATTCCTGGGAATCCACAGTAAAAGGAAAGAAGTG
CATTGTTTTGGTGACTGAACTTATGACGTCTGGAACACTTAAAACGTATCTGAAAAGGTTTAAAGTGATGAAGATCAAAGTTCTAAGAAG
CTGGTGCCGTCAGATCCTTAAAGGTCTTCAGTTTCTTCATACTCGAACTCCACCTATCATTCACCGCGATCTTAAATGTGACAACATCTT
TATCACCGGCCCTACTGGCTCAGTCAAGATTGGAGACCTCGGTCTGGCAACCCTGAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTAC
CCCAGAGTTCATGGCCCCTGAGATGTATGAGGAGAAATATGATGAATCCGTTGACGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGC
TACATCTGAATATCCTTACTCGGAGTGCCAAAATGCTGCACAGATCTACCGTCGCGTGACCAGTGGGGTGAAGCCAGCCAGTTTTGACAA
AGTAGCAATTCCTGAAGTGAAGGAAATTATTGAAGGATGCATACGACAAAACAAAGATGAAAGATATTCCATCAAAGACCTTTTGAACCA
TGCCTTCTTCCAAGAGGAAACAGGAGTACGGGTAGAATTAGCAGAAGAAGATGATGGAGAAAAAATAGCCATAAAATTATGGCTACGTAT
TGAAGATATTAAGAAATTAAAGGGAAAATACAAAGATAATGAAGCTATTGAGTTTTCTTTTGATTTAGAGAGAGATGTCCCAGAAGATGT
TGCACAAGAAATGGTAGAGTCTGGGTATGTCTGTGAAGGTGATCACAAGACCATGGCTAAAGCTATCAAAGACAGAGTATCATTAATTAA
GAGGAAACGAGAGCAGCGGCAGTTGGTACGGGAGGAGCAAGAAAAAAAAAAGCAGGAAGAGAGCAGTCTCAAACAGCAGGTAGAACAATC
CAGTGCTTCCCAGACAGGAATCAAGCAGCTCCCTTCTGCTAGCACCGGCATACCTACTGCTTCTACCACTTCAGCTTCAGTTTCTACACA
AGTAGAACCTGAAGAACCTGAGGCAGATCAACATCAACAACTACAGTACCAGCAACCCAGTATATCTGTGTTATCTGATGGGACGGTTGA
CAGTGGTCAGGGATCCTCTGTCTTCACAGAATCTCGAGTGAGCAGCCAACAGACAGTTTCATATGGTTCCCAACATGAACAGGCACATTC
TACAGGCACAGTCCCAGGGCATATACCTTCTACTGTCCAAGCACAGTCTCAGCCCCATGGGGTATATCCACCCTCAAGTGTGGTGAACAG
CCCCCCCTCCCAGCCCCCCCAGCCCGTCGTCCCTGCTAAGCCCGTGCAATGCGTCCATCATGTGTCCACTCAACCCAGCTGCCCAGGACG
GGGCAAGATGTCCAAGCTGCTGAACCCAGAGGAGATGACCTCGAGAGATTATTACTTCGACTCCTATGCCCACTTTGGGATCCACGAGGA
AATGCTGAAGGATGAGGTGCGGACTCTCACTTACCGGAACTCCATGTACCACAACAAGCACGTGTTCAAGGACAAAGTGGTACTGGATGT
GGGGAGTGGTACTGGGATCCTTTCCATGTTCGCTGCCAAGGCAGGGGCCAAGAAGGTGTTTGGGATCGAATGCTCCAGTATTTCTGACTA
CTCAGAGAAGATCATTAAGGCCAACCACTTGGACAACATCATCACCATATTTAAGGGTAAAGTGGAAGAGGTGGAGCTGCCTGTGGAGAA
GGTGGACATCATCATCAGCGAGTGGATGGGCTACTGTCTGTTCTATGAGTCCATGCTCAACACGGTGATCTTTGCCAGGGACAAGTGGCT
GAAACCTGGAGGGCTTATGTTTCCAGACCGGGCAGCTTTGTACGTGGTAGCGATTGAAGACAGACAGTACAAGGACTTCAAAATCCACTG
GTGGGAGAATGTCTATGGCTTTGACATGACCTGCATCCGGGACGTGGCCATGAAGGAGCCTCTAGTGGACATCGTGGATCCAAAGCAAGT
GGTGACCAATGCCTGTTTGATAAAGGAGGTGGACATTTACACAGTGAAGACGGAAGAGCTATCGTTCACATCTGCATTCTGCCTGCAGAT
ACAGCGCAACGACTACGTCCACGCCCTGGTCACCTATTTTAATATTGAATTTACCAAGTGCCACAAGAAAATGGGGTTTTCCACAGCCCC
TGATGCTCCCTACACCCACTGGAAGCAGACCGTCTTCTACTTGGAAGATTACCTCACTGTCCGGAGGGGGGAGGAAATCTACGGGACCAT
ATCCATGAAGCCAAATGCCAAAAATGTGCGAGACCTCGATTTCACAGTAGACTTGGATTTTAAGGGACAGCTGTGTGAAACATCTGTATC
TAATGACTACAAAATGCGTTAGCACACGTGGGAAGCTGCAGAGAGCAACGAGAAAAGGAACTCTCACCTCGATCTGCCGTGCCGTCCCAA
AGAATACCGTTTGCAGGACTACACACTTGAAAACCAGAGTTTTCAACTCTGCCTTGAAGATTGGTGAACTCCCCAGGGCTCCCGTGGGCT
CTGCCACTGGACAGAAGGCCTCCAGCTCCTCCGCTCTGCCCTGGTAGCCCTTCACGAAGGCTTTGTGTTGCCAACAAAGAGCGACCTGGC
GTGCTGTGGCTGGGCCCCGAGGGTGGAAACGTATTCGCGTCTCCCCGTCTCCTCCTTAACTGTGACTCTCCGGGTCTTCTGAGTTTTGCA
TGCTGCGGGTGTCTAGGACAGATTGCTTCCACTAGAACCTGGAGACATAGCATCTTTGATAGCATAAGCCAGATTATCTGTGTGTGCGGT
GGTGTGCGTGTGCGTGCATGTGTGAATGTGAGCAGCATAGTTGATATTTACCCACAAACACCTGTATATGCGTGCATATACAACCAAGTG
GGTAGACCTAGGTGTTCTCTCAGAGGGGTGTGTGTGTGTGTGCGTGCGCGTGTGCCTAGAATATATATTACTCTCAGAGGAGATTCTGTT
GCTTTTGAATAGGAATTTGTTTTGTGATTAGTTCGCCCCTTCCCCACCCCTTACCAGATGTTAAGCAGCTATGAAACATTCTCTGTACTA
GTTCTGGTCTCCTTTTGACTGGACTGTGGCTCTGAACCTTGAGCATAGTACCACGGACTCCGTGGGCGCTCAATAAACACACATGAGAAC

>99337_99337_9_WNK1-PRMT8_WNK1_chr12_971436_ENST00000537687_PRMT8_chr12_3649772_ENST00000382622_length(amino acids)=1131AA_BP=762
MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA
AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS
QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL
KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKT
YLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDE
SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAE
EDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEK
KKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSS
QQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSR
DYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIIT
IFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDV
AMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLE

--------------------------------------------------------------
>99337_99337_10_WNK1-PRMT8_WNK1_chr12_971436_ENST00000537687_PRMT8_chr12_3649772_ENST00000452611_length(transcript)=3892nt_BP=2782nt
CCGGCCCTTCGCCTCTGGGCGATGGGCGACCTGTGAGGCCGGTCCCCATCGCTGGGGGCGCGTGTGGGAGGAGGCGGCCGCCCGAGTGAC
CGGGAGCCGGGCCGCGGCCTTCCCTCGCCCGCCTCGGCCCCTCCCACTCCTCTGCCCCGGGGCCGCCACCGCCCGGGCGTCGGACCTGGT
CCCGTGCTCGCGGTGCCGCCGCCCTCTGGGCCTAGCCCGCCCAGCTCGGCGAGCGGCGGCAGTGGGAGCCGCGTCCGCCGCATCCGCCTC
GACTCGGTGCCGGCCCCTGGCCCTCCCCTCATGACTGCGGCGCCTCTGCTGCCACCGCCCGCCCGGCCGCCGCTCGCCGCAGGATGGATG
CGGACCGTGCGGCGCTAACCCCCGTGGCTCAGCTCCCGAATCGCCCGCCTTCGAGCCCTCCTCGTGAGCCGCAGCAGCCTCGGTGCCAGC
CCCCGCCGCAGCTGGGCCCAGCGGTCCGCCTGTCCCTCGTTGCGGCTTGTCGGTGCTGAGTGAGGCGTCGTCCGGGTCGGCGCGAACCCG
CCCGGCCGCGGTTCCCTGCAGACCTCTGCGCGGGCGGCTCGGCCCTTCACGCCCTTTTCGTTCACGAATCCGAGCCCGCTCGCCTCTCTC
CAGCGAACCGACCATGTCTGGCGGCGCCGCAGAGAAGCAGAGCAGCACTCCCGGTTCCCTGTTCCTCTCGCCGCCGGCTCCTGCCCCCAA
GAATGGCTCCAGCTCCGATTCCTCCGTGGGGGAGAAACTGGGAGCCGCGGCCGCCGACGCTGTGACCGGCAGGACCGAGGAGTACAGGCG
CCGCCGCCACACTATGGACAAGGACAGCCGTGGGGCGGCCGCGACCACTACCACCACTGAGCACCGCTTCTTCCGCCGGAGCGTCATCTG
TGACTCCAATGCCACTGCACTGGAGCTTCCCGGCCTTCCTCTTTCCCTGCCCCAGCCCAGCATCCCCGCGGCTGTCCCGCAGAGTGCTCC
ACCGGAGCCCCACCGGGAAGAGACCGTGACCGCCACCGCCACTTCCCAGGTAGCCCAGCAGCCTCCAGCCGCTGCCGCCCCTGGGGAACA
GGCCGTCGCGGGCCCTGCCCCCTCGACTGTCCCCAGCAGTACCAGCAAAGACCGCCCAGTGTCCCAGCCTAGCCTTGTGGGGAGCAAAGA
GGAGCCGCCGCCGGCGAGAAGTGGCAGCGGCGGCGGCAGCGCCAAGGAGCCACAGGAGGAACGGAGCCAGCAGCAGGATGATATCGAAGA
GCTGGAGACCAAGGCCGTGGGAATGTCTAACGATGGCCGCTTTCTCAAGTTTGACATCGAAATCGGCAGAGGCTCCTTTAAGACGGTCTA
CAAAGGTCTGGACACTGAAACCACCGTGGAAGTCGCCTGGTGTGAACTGCAGGATCGAAAATTAACAAAGTCTGAGAGGCAGAGATTTAA
AGAAGAAGCTGAAATGTTAAAAGGTCTTCAGCATCCCAATATTGTTAGATTTTATGATTCCTGGGAATCCACAGTAAAAGGAAAGAAGTG
CATTGTTTTGGTGACTGAACTTATGACGTCTGGAACACTTAAAACGTATCTGAAAAGGTTTAAAGTGATGAAGATCAAAGTTCTAAGAAG
CTGGTGCCGTCAGATCCTTAAAGGTCTTCAGTTTCTTCATACTCGAACTCCACCTATCATTCACCGCGATCTTAAATGTGACAACATCTT
TATCACCGGCCCTACTGGCTCAGTCAAGATTGGAGACCTCGGTCTGGCAACCCTGAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTAC
CCCAGAGTTCATGGCCCCTGAGATGTATGAGGAGAAATATGATGAATCCGTTGACGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGC
TACATCTGAATATCCTTACTCGGAGTGCCAAAATGCTGCACAGATCTACCGTCGCGTGACCAGTGGGGTGAAGCCAGCCAGTTTTGACAA
AGTAGCAATTCCTGAAGTGAAGGAAATTATTGAAGGATGCATACGACAAAACAAAGATGAAAGATATTCCATCAAAGACCTTTTGAACCA
TGCCTTCTTCCAAGAGGAAACAGGAGTACGGGTAGAATTAGCAGAAGAAGATGATGGAGAAAAAATAGCCATAAAATTATGGCTACGTAT
TGAAGATATTAAGAAATTAAAGGGAAAATACAAAGATAATGAAGCTATTGAGTTTTCTTTTGATTTAGAGAGAGATGTCCCAGAAGATGT
TGCACAAGAAATGGTAGAGTCTGGGTATGTCTGTGAAGGTGATCACAAGACCATGGCTAAAGCTATCAAAGACAGAGTATCATTAATTAA
GAGGAAACGAGAGCAGCGGCAGTTGGTACGGGAGGAGCAAGAAAAAAAAAAGCAGGAAGAGAGCAGTCTCAAACAGCAGGTAGAACAATC
CAGTGCTTCCCAGACAGGAATCAAGCAGCTCCCTTCTGCTAGCACCGGCATACCTACTGCTTCTACCACTTCAGCTTCAGTTTCTACACA
AGTAGAACCTGAAGAACCTGAGGCAGATCAACATCAACAACTACAGTACCAGCAACCCAGTATATCTGTGTTATCTGATGGGACGGTTGA
CAGTGGTCAGGGATCCTCTGTCTTCACAGAATCTCGAGTGAGCAGCCAACAGACAGTTTCATATGGTTCCCAACATGAACAGGCACATTC
TACAGGCACAGTCCCAGGGCATATACCTTCTACTGTCCAAGCACAGTCTCAGCCCCATGGGGTATATCCACCCTCAAGTGTGGTGAACAG
CCCCCCCTCCCAGCCCCCCCAGCCCGTCGTCCCTGCTAAGCCCGTGCAATGCGTCCATCATGTGTCCACTCAACCCAGCTGCCCAGGACG
GGGCAAGATGTCCAAGCTGCTGAACCCAGAGGAGATGACCTCGAGAGATTATTACTTCGACTCCTATGCCCACTTTGGGATCCACGAGGA
AATGCTGAAGGATGAGGTGCGGACTCTCACTTACCGGAACTCCATGTACCACAACAAGCACGTGTTCAAGGACAAAGTGGTACTGGATGT
GGGGAGTGGTACTGGGATCCTTTCCATGTTCGCTGCCAAGGCAGGGGCCAAGAAGGTGTTTGGGATCGAATGCTCCAGTATTTCTGACTA
CTCAGAGAAGATCATTAAGGCCAACCACTTGGACAACATCATCACCATATTTAAGGGTAAAGTGGAAGAGGTGGAGCTGCCTGTGGAGAA
GGTGGACATCATCATCAGCGAGTGGATGGGCTACTGTCTGTTCTATGAGTCCATGCTCAACACGGTGATCTTTGCCAGGGACAAGTGGCT
GAAACCTGGAGGGCTTATGTTTCCAGACCGGGCAGCTTTGTACGTGGTAGCGATTGAAGACAGACAGTACAAGGACTTCAAAATCCACTG
GTGGGAGAATGTCTATGGCTTTGACATGACCTGCATCCGGGACGTGGCCATGAAGGAGCCTCTAGTGGACATCGTGGATCCAAAGCAAGT
GGTGACCAATGCCTGTTTGATAAAGGAGGTGGACATTTACACAGTGAAGACGGAAGAGCTATCGTTCACATCTGCATTCTGCCTGCAGAT
ACAGCGCAACGACTACGTCCACGCCCTGGTCACCTATTTTAATATTGAATTTACCAAGTGCCACAAGAAAATGGGGTTTTCCACAGCCCC
TGATGCTCCCTACACCCACTGGAAGCAGACCGTCTTCTACTTGGAAGATTACCTCACTGTCCGGAGGGGGGAGGAAATCTACGGGACCAT
ATCCATGAAGCCAAATGCCAAAAATGTGCGAGACCTCGATTTCACAGTAGACTTGGATTTTAAGGGACAGCTGTGTGAAACATCTGTATC

>99337_99337_10_WNK1-PRMT8_WNK1_chr12_971436_ENST00000537687_PRMT8_chr12_3649772_ENST00000452611_length(amino acids)=1132AA_BP=762
MSVLSEASSGSARTRPAAVPCRPLRGRLGPSRPFRSRIRARSPLSSEPTMSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGA
AAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATS
QVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFL
KFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKT
YLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDE
SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAE
EDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEK
KKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSS
QQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSR
DYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIIT
IFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDV
AMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WNK1-PRMT8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WNK1-PRMT8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WNK1-PRMT8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource