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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BMPR2-PARD3B (FusionGDB2 ID:9936)

Fusion Gene Summary for BMPR2-PARD3B

check button Fusion gene summary
Fusion gene informationFusion gene name: BMPR2-PARD3B
Fusion gene ID: 9936
HgeneTgene
Gene symbol

BMPR2

PARD3B

Gene ID

659

117583

Gene namebone morphogenetic protein receptor type 2par-3 family cell polarity regulator beta
SynonymsBMPR-II|BMPR3|BMR2|BRK-3|POVD1|PPH1|T-ALKALS2CR19|PAR3B|PAR3L|PAR3beta
Cytomap

2q33.1-q33.2

2q33.3

Type of geneprotein-codingprotein-coding
Descriptionbone morphogenetic protein receptor type-2BMP type II receptorBMP type-2 receptorbone morphogenetic protein receptor type IIbone morphogenetic protein receptor, type II (serine/threonine kinase)type II activin receptor-like kinasetype II receptor fopartitioning defective 3 homolog BPAR3-L proteinamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 19amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 proteinpar-3 partitioning defective 3 homolog Bpartitioning
Modification date2020031320200313
UniProtAcc

Q13873

.
Ensembl transtripts involved in fusion geneENST00000374574, ENST00000374580, 
ENST00000479069, 		ENST00000488622, 
ENST00000349953, ENST00000351153, 
ENST00000358768, ENST00000406610, 
ENST00000462231, 
Fusion gene scores* DoF score20 X 12 X 9=216017 X 20 X 10=3400
# samples 2123
** MAII scorelog2(21/2160*10)=-3.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3400*10)=-3.88582898008069
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BMPR2 [Title/Abstract] AND PARD3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBMPR2(203242273)-PARD3B(206110501), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBMPR2

GO:0007178

transmembrane receptor protein serine/threonine kinase signaling pathway

12045205

HgeneBMPR2

GO:0010634

positive regulation of epithelial cell migration

12819188

HgeneBMPR2

GO:0030308

negative regulation of cell growth

12819188

HgeneBMPR2

GO:0030509

BMP signaling pathway

18436533


check buttonFusion gene breakpoints across BMPR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PARD3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A6FHBMPR2chr2

203242273

+PARD3Bchr2

206110501

+


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Fusion Gene ORF analysis for BMPR2-PARD3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000374574ENST00000488622BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
5CDS-intronENST00000374580ENST00000488622BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
In-frameENST00000374574ENST00000349953BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
In-frameENST00000374574ENST00000351153BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
In-frameENST00000374574ENST00000358768BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
In-frameENST00000374574ENST00000406610BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
In-frameENST00000374574ENST00000462231BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
In-frameENST00000374580ENST00000349953BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
In-frameENST00000374580ENST00000351153BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
In-frameENST00000374580ENST00000358768BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
In-frameENST00000374580ENST00000406610BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
In-frameENST00000374580ENST00000462231BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
intron-3CDSENST00000479069ENST00000349953BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
intron-3CDSENST00000479069ENST00000351153BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
intron-3CDSENST00000479069ENST00000358768BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
intron-3CDSENST00000479069ENST00000406610BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
intron-3CDSENST00000479069ENST00000462231BMPR2chr2

203242273

+PARD3Bchr2

206110501

+
intron-intronENST00000479069ENST00000488622BMPR2chr2

203242273

+PARD3Bchr2

206110501

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374580BMPR2chr2203242273+ENST00000406610PARD3Bchr2206110501+64426155242092522
ENST00000374580BMPR2chr2203242273+ENST00000462231PARD3Bchr2206110501+12836155241282253
ENST00000374580BMPR2chr2203242273+ENST00000349953PARD3Bchr2206110501+17906155241789422
ENST00000374580BMPR2chr2203242273+ENST00000358768PARD3Bchr2206110501+20936155242092523
ENST00000374580BMPR2chr2203242273+ENST00000351153PARD3Bchr2206110501+18866155241885454
ENST00000374574BMPR2chr2203242273+ENST00000406610PARD3Bchr2206110501+5944117261594522
ENST00000374574BMPR2chr2203242273+ENST00000462231PARD3Bchr2206110501+78511726784253
ENST00000374574BMPR2chr2203242273+ENST00000349953PARD3Bchr2206110501+1292117261291422
ENST00000374574BMPR2chr2203242273+ENST00000358768PARD3Bchr2206110501+1595117261594523
ENST00000374574BMPR2chr2203242273+ENST00000351153PARD3Bchr2206110501+1388117261387454

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374580ENST00000406610BMPR2chr2203242273+PARD3Bchr2206110501+0.0015699860.99842995
ENST00000374580ENST00000462231BMPR2chr2203242273+PARD3Bchr2206110501+0.008935270.9910648
ENST00000374580ENST00000349953BMPR2chr2203242273+PARD3Bchr2206110501+0.022890320.97710973
ENST00000374580ENST00000358768BMPR2chr2203242273+PARD3Bchr2206110501+0.0204749310.9795251
ENST00000374580ENST00000351153BMPR2chr2203242273+PARD3Bchr2206110501+0.0106221490.9893778
ENST00000374574ENST00000406610BMPR2chr2203242273+PARD3Bchr2206110501+0.001377610.9986224
ENST00000374574ENST00000462231BMPR2chr2203242273+PARD3Bchr2206110501+0.0065876770.9934123
ENST00000374574ENST00000349953BMPR2chr2203242273+PARD3Bchr2206110501+0.028298030.971702
ENST00000374574ENST00000358768BMPR2chr2203242273+PARD3Bchr2206110501+0.0230972490.9769027
ENST00000374574ENST00000351153BMPR2chr2203242273+PARD3Bchr2206110501+0.0127263330.9872737

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Fusion Genomic Features for BMPR2-PARD3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BMPR2chr2203242273+PARD3Bchr2206110501+1.71E-070.9999999
BMPR2chr2203242273+PARD3Bchr2206110501+1.71E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BMPR2-PARD3B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:203242273/chr2:206110501)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BMPR2

Q13873

.
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. {ECO:0000250|UniProtKB:O35607}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePARD3Bchr2:203242273chr2:206110501ENST0000034995314221144_11497131105.0Compositional biasNote=Poly-Pro
TgenePARD3Bchr2:203242273chr2:206110501ENST000003499531422830_8967131105.0Compositional biasNote=Lys-rich
TgenePARD3Bchr2:203242273chr2:206110501ENST0000035876813221144_11496511144.0Compositional biasNote=Poly-Pro
TgenePARD3Bchr2:203242273chr2:206110501ENST000003587681322830_8966511144.0Compositional biasNote=Lys-rich
TgenePARD3Bchr2:203242273chr2:206110501ENST0000040661014231144_11497131206.0Compositional biasNote=Poly-Pro
TgenePARD3Bchr2:203242273chr2:206110501ENST000004066101423830_8967131206.0Compositional biasNote=Lys-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBMPR2chr2:203242273chr2:206110501ENST00000374580+113547_550251039.0Compositional biasNote=Poly-Ser
HgeneBMPR2chr2:203242273chr2:206110501ENST00000374580+113610_618251039.0Compositional biasNote=Poly-Thr
HgeneBMPR2chr2:203242273chr2:206110501ENST00000374580+113901_908251039.0Compositional biasNote=Poly-Asn
HgeneBMPR2chr2:203242273chr2:206110501ENST00000374580+113203_504251039.0DomainProtein kinase
HgeneBMPR2chr2:203242273chr2:206110501ENST00000374580+113209_217251039.0Nucleotide bindingATP
HgeneBMPR2chr2:203242273chr2:206110501ENST00000374580+113280_282251039.0Nucleotide bindingATP
HgeneBMPR2chr2:203242273chr2:206110501ENST00000374580+113337_338251039.0Nucleotide bindingATP
HgeneBMPR2chr2:203242273chr2:206110501ENST00000374580+113172_1038251039.0Topological domainCytoplasmic
HgeneBMPR2chr2:203242273chr2:206110501ENST00000374580+11327_150251039.0Topological domainExtracellular
HgeneBMPR2chr2:203242273chr2:206110501ENST00000374580+113151_171251039.0TransmembraneHelical
TgenePARD3Bchr2:203242273chr2:206110501ENST000003499531422201_2897131105.0DomainPDZ 1
TgenePARD3Bchr2:203242273chr2:206110501ENST000003499531422383_4687131105.0DomainPDZ 2
TgenePARD3Bchr2:203242273chr2:206110501ENST000003499531422498_5857131105.0DomainPDZ 3
TgenePARD3Bchr2:203242273chr2:206110501ENST000003587681322201_2896511144.0DomainPDZ 1
TgenePARD3Bchr2:203242273chr2:206110501ENST000003587681322383_4686511144.0DomainPDZ 2
TgenePARD3Bchr2:203242273chr2:206110501ENST000003587681322498_5856511144.0DomainPDZ 3
TgenePARD3Bchr2:203242273chr2:206110501ENST000004066101423201_2897131206.0DomainPDZ 1
TgenePARD3Bchr2:203242273chr2:206110501ENST000004066101423383_4687131206.0DomainPDZ 2
TgenePARD3Bchr2:203242273chr2:206110501ENST000004066101423498_5857131206.0DomainPDZ 3


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Fusion Gene Sequence for BMPR2-PARD3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9936_9936_1_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374574_PARD3B_chr2_206110501_ENST00000349953_length(transcript)=1292nt_BP=117nt
ATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGA
CCATCCTGCTGGTCAGCACTGCGGCTGTGCCAGATGAAAGCAAGGTTCACTCATTGGCTGGACAAAAATCGGAATCTCCAAGCAAAGATT
TTGGTCCAACTCTGGGTTTGAAAAAGTCCAGCTCCTTGGAGAGTCTGCAGACTGCAGTGGCCGAGGTCAGGAAGAATGACCTTCCCTTTC
ACAGGCCCCGGCCGCACATGGTTCGAGGCCGAGGCTGCAATGAGAGCTTTAGAGCAGCCATTGACAAATCCTACGATGGACCTGAAGAAA
TAGAAGCTGACGGTCTGTCTGATAAGAGCTCTCACTCTGGCCAAGGAGCTCTGAATTGTGAGTCTGCCCCTCAGGGGAATTCGGAGCTAG
AGGACATGGAAAATAAAGCCAGGAAAGTCAAAAAAACGAAAGAGAAGGAGAAGAAAAAGGAAAAGGGCAAATTGAAAGTCAAGGAGAAAA
AGCGCAAAGAGGAGAATGAAGATCCAGAAAGGAAAATAAAGAAGAAGGGCTTCGGCGCCATGCTGAGATTTGGAAAGAAGAAAGAGGATA
AGGGTGGAAAGGCTGAGCAGAAAGGTACTCTGAAACATGGTGGCCTGAGAGAAGAAGAGCTGGAGAAAATGAAAGAAGAGCGTGAAAGTG
GCCGTCCTACGGGTGGAAGCACTGACCGTATCCAGAAGTTGCGGAAAGAGTATTATCAGGCTCGGAGGGAAGGTTTCCCTTTATATGAAG
ACGACGAAGGAAGAGCAAGGCCATCTGAGTATGACCTACTCTGGGTGCCTGGAAGGGGTCCAGATGGGAATGCACACAACCTCCGCTTTG
AAGGGATGGAGAGGCAGTACGCATCCTTACCCAGGGGAGGACCCGCAGATCCTGTAGACTATCTGCCAGCAGCACCTCGGGGGCTCTACA
AGGAAAGGGAGCTTCCCTATTATCCAGGGGCTCATCCTATGCACCCTCCCAAAGGGAGCTATCCCCGCCCCACAGAGCTCAGGGTGGCAG
ATCTCCGGTATCCTCAGCACTACCCACCCCCGCCAGCTCCCCAGCACAAAGGACCCTTTCGACAAGACGTTCCGCCTTCCCCTCCCCAGC
ACCAAAGAATGCCAGCCTATCAGGAAACAGGCAGACCAGGGCCCCGTGGGGGCAGCCCAGACCAGTACCCTTACCGAACCCAGGATTCCC

>9936_9936_1_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374574_PARD3B_chr2_206110501_ENST00000349953_length(amino acids)=422AA_BP=30
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVR
GRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDP
ERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPS
EYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYPQHYP

--------------------------------------------------------------
>9936_9936_2_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374574_PARD3B_chr2_206110501_ENST00000351153_length(transcript)=1388nt_BP=117nt
ATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGA
CCATCCTGCTGGTCAGCACTGCGGCTGTGCCAGATGAAAGCAAGGTTCACTCATTGGCTGGACAAAAATCGGACGGTCTGTCTGATAAGA
GCTCTCACTCTGGCCAAGGAGCTCTGAATTGTGAGTCTGCCCCTCAGGGGAATTCGGAGCTAGAGGACATGGAAAATAAAGCCAGGAAAG
TCAAAAAAACGAAAGAGAAGGAGAAGAAAAAGGAAAAGGGCAAATTGAAAGTCAAGGAGAAAAAGCGCAAAGAGGAGAATGAAGATCCAG
AAAGGAAAATAAAGAAGAAGGGCTTCGGCGCCATGCTGAGATTTGGAAAGAAGAAAGAGGATAAGGGTGGAAAGGCTGAGCAGAAAGGTA
CTCTGAAACATGGTGGCCTGAGAGAAGAAGAGCTGGAGAAAATGAAAGAAGAGCGTGAAAGGATTGGAGCAAAACATCAGGAGCTAAGGG
AAAAGCAGGCAAGAGGTCTTCTTGATTATGCTACTGGTGCAATTGGATCAGTGTATGATATGGATGATGATGAAATGGACCCCAATTATG
CCAGAGTGAACCACTTTCGGGAACCATGCACATCAGCAAATGTCTTTAGATCTCCATCTCCCCCTCGAGCTGGACCATTTGGTTACCCTC
GGGATGGCCATCCACTGTCTCCAGAAAGAGACCACTTAGAGGGTCTCTATGCCAAGGTCAACAAGCCATACCATCCACTGGTTCCAGCTG
ACAGTGGCCGTCCTACGGGTGGAAGCACTGACCGTATCCAGAAGTTGCGGAAAGAGTATTATCAGGCTCGGAGGGAAGGTTTCCCTTTAT
ATGAAGACGACGAAGGAAGAGCAAGGCCATCTGAGTATGACCTACTCTGGGTGCCTGGAAGGGGTCCAGATGGGAATGCACACAACCTCC
GCTTTGAAGGGATGGAGAGGCAGTACGCATCCTTACCCAGGGGAGGACCCGCAGATCCTGTAGACTATCTGCCAGCAGCACCTCGGGGGC
TCTACAAGGAAAGGGAGCTTCCCTATTATCCAGGGGCTCATCCTATGCACCCTCCCAAAGGGAGCTATCCCCGCCCCACAGAGCTCAGGG
TGGCAGATCTCCGGTATCCTCAGCACTACCCACCCCCGCCAGCTCCCCAGCACAAAGGACCCTTTCGACAAGACGTTCCGCCTTCCCCTC
CCCAGCACCAAAGAATGCCAGCCTATCAGGAAACAGGCAGACCAGGGCCCCGTGGGGGCAGCCCAGACCAGTACCCTTACCGAACCCAGG

>9936_9936_2_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374574_PARD3B_chr2_206110501_ENST00000351153_length(amino acids)=454AA_BP=30
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAVPDESKVHSLAGQKSDGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEK
KKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQARGLLD
YATGAIGSVYDMDDDEMDPNYARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGS
TDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPY
YPGAHPMHPPKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNPMT

--------------------------------------------------------------
>9936_9936_3_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374574_PARD3B_chr2_206110501_ENST00000358768_length(transcript)=1595nt_BP=117nt
ATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGA
CCATCCTGCTGGTCAGCACTGCGGCTGTGCCAGATGAAAGCAAGGTTCACTCATTGGCTGGACAAAAATCGGAATCTCCAAGCAAAGATT
TTGGTCCAACTCTGGGTTTGAAAAAGTCCAGCTCCTTGGAGAGTCTGCAGACTGCAGTGGCCGAGGTCAGGAAGAATGACCTTCCCTTTC
ACAGGCCCCGGCCGCACATGGTTCGAGGCCGAGGCTGCAATGAGAGCTTTAGAGCAGCCATTGACAAATCCTACGATGGACCTGAAGAAA
TAGAAGCTGACGGTCTGTCTGATAAGAGCTCTCACTCTGGCCAAGGAGCTCTGAATTGTGAGTCTGCCCCTCAGGGGAATTCGGAGCTAG
AGGACATGGAAAATAAAGCCAGGAAAGTCAAAAAAACGAAAGAGAAGGAGAAGAAAAAGGAAAAGGGCAAATTGAAAGTCAAGGAGAAAA
AGCGCAAAGAGGAGAATGAAGATCCAGAAAGGAAAATAAAGAAGAAGGGCTTCGGCGCCATGCTGAGATTTGGAAAGAAGAAAGAGGATA
AGGGTGGAAAGGCTGAGCAGAAAGGTACTCTGAAACATGGTGGCCTGAGAGAAGAAGAGCTGGAGAAAATGAAAGAAGAGCGTGAAAGGA
TTGGAGCAAAACATCAGGAGCTAAGGGAAAAGCAGGCAAGAGGTCTTCTTGATTATGCTACTGGTGCAATTGGATCAGTGTATGATATGG
ATGATGATGAAATGGACCCCAATTATGCCAGAGTGAACCACTTTCGGGAACCATGCACATCAGCAAATGTCTTTAGATCTCCATCTCCCC
CTCGAGCTGGACCATTTGGTTACCCTCGGGATGGCCATCCACTGTCTCCAGAAAGAGACCACTTAGAGGGTCTCTATGCCAAGGTCAACA
AGCCATACCATCCACTGGTTCCAGCTGACAGTGGCCGTCCTACGGGTGGAAGCACTGACCGTATCCAGAAGTTGCGGAAAGAGTATTATC
AGGCTCGGAGGGAAGGTTTCCCTTTATATGAAGACGACGAAGGAAGAGCAAGGCCATCTGAGTATGACCTACTCTGGGTGCCTGGAAGGG
GTCCAGATGGGAATGCACACAACCTCCGCTTTGAAGGGATGGAGAGGCAGTACGCATCCTTACCCAGGGGAGGACCCGCAGATCCTGTAG
ACTATCTGCCAGCAGCACCTCGGGGGCTCTACAAGGAAAGGGAGCTTCCCTATTATCCAGGGGCTCATCCTATGCACCCTCCCAAAGGGA
GCTATCCCCGCCCCACAGAGCTCAGGGTGGCAGATCTCCGGTATCCTCAGCACTACCCACCCCCGCCAGCTCCCCAGCACAAAGGACCCT
TTCGACAAGACGTTCCGCCTTCCCCTCCCCAGCACCAAAGAATGCCAGCCTATCAGGAAACAGGCAGACCAGGGCCCCGTGGGGGCAGCC

>9936_9936_3_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374574_PARD3B_chr2_206110501_ENST00000358768_length(amino acids)=523AA_BP=30
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVR
GRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDP
ERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNY
ARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLRKEYYQARREGFPL
YEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR

--------------------------------------------------------------
>9936_9936_4_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374574_PARD3B_chr2_206110501_ENST00000406610_length(transcript)=5944nt_BP=117nt
ATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGA
CCATCCTGCTGGTCAGCACTGCGGCTGTGCCAGATGAAAGCAAGGTTCACTCATTGGCTGGACAAAAATCGGAATCTCCAAGCAAAGATT
TTGGTCCAACTCTGGGTTTGAAAAAGTCCAGCTCCTTGGAGAGTCTGCAGACTGCAGTGGCCGAGGTCAGGAAGAATGACCTTCCCTTTC
ACAGGCCCCGGCCGCACATGGTTCGAGGCCGAGGCTGCAATGAGAGCTTTAGAGCAGCCATTGACAAATCCTACGATGGACCTGAAGAAA
TAGAAGCTGACGGTCTGTCTGATAAGAGCTCTCACTCTGGCCAAGGAGCTCTGAATTGTGAGTCTGCCCCTCAGGGGAATTCGGAGCTAG
AGGACATGGAAAATAAAGCCAGGAAAGTCAAAAAAACGAAAGAGAAGGAGAAGAAAAAGGAAAAGGGCAAATTGAAAGTCAAGGAGAAAA
AGCGCAAAGAGGAGAATGAAGATCCAGAAAGGAAAATAAAGAAGAAGGGCTTCGGCGCCATGCTGAGATTTGGAAAGAAGAAAGAGGATA
AGGGTGGAAAGGCTGAGCAGAAAGGTACTCTGAAACATGGTGGCCTGAGAGAAGAAGAGCTGGAGAAAATGAAAGAAGAGCGTGAAAGGA
TTGGAGCAAAACATCAGGAGCTAAGGGAAAAGCAGGCAAGAGGTCTTCTTGATTATGCTACTGGTGCAATTGGATCAGTGTATGATATGG
ATGATGATGAAATGGACCCCAATTATGCCAGAGTGAACCACTTTCGGGAACCATGCACATCAGCAAATGTCTTTAGATCTCCATCTCCCC
CTCGAGCTGGACCATTTGGTTACCCTCGGGATGGCCATCCACTGTCTCCAGAAAGAGACCACTTAGAGGGTCTCTATGCCAAGGTCAACA
AGCCATACCATCCACTGGTTCCAGCTGACAGTGGCCGTCCTACGGGTGGAAGCACTGACCGTATCCAGAAGTTGCGGAAAGAGTATTATC
AGGCTCGGAGGGAAGGTTTCCCTTTATATGAAGACGACGAAGGAAGAGCAAGGCCATCTGAGTATGACCTACTCTGGGTGCCTGGAAGGG
GTCCAGATGGGAATGCACACAACCTCCGCTTTGAAGGGATGGAGAGGCAGTACGCATCCTTACCCAGGGGAGGACCCGCAGATCCTGTAG
ACTATCTGCCAGCAGCACCTCGGGGGCTCTACAAGGAAAGGGAGCTTCCCTATTATCCAGGGGCTCATCCTATGCACCCTCCCAAAGGGA
GCTATCCCCGCCCCACAGAGCTCAGGGTGGCAGATCTCCGGTATCCTCAGCACTACCCACCCCCGCCAGCTCCCCAGCACAAAGGACCCT
TTCGACAAGACGTTCCGCCTTCCCCTCCCCAGCACCAAAGAATGCCAGCCTATCAGGAAACAGGCAGACCAGGGCCCCGTGGGGGCAGCC
CAGACCAGTACCCTTACCGAACCCAGGATTCCCGGCAGAAGAACCCCATGACTGCAGCCGTATAGCTGAGTGCCACCGAGGCCAGCCCGG
TCCAGAAAGGAAGGTGTCTACTCTACCTTTGCCCTTTCTAAACCTGAAGACCTCCTTGGTGTTAGGAATTCTCCATGTTACTGATAAGCT
TTTTCTCACTGACATTGTAACGCATGACTGCTAATCAGAGAGAAAAAGAAGGGGAAGGGAATTGGGGAGGAAAAAAAATCAGAAGGAAGA
CGAAAGATGGGGCTATAAAAACAAAACTACCTGATAGTTGAAACGCTTTCAGAGTTGTTCAAATCAGTGAGAGTGGCAACGGAACACACA
AACAACTAATTATGGAACTCTACTCTGGGGATCCTCTCTGGCTAGATAACCTGTGCTGATGTGCAGACACGTGGACATCCCCCTCTGAGA
CTGGCGGTCCAGAGGCAGTCTCTGCCAGGCAGCATTACCCGCTCCGAGGTGGAGCCTCAGCCCCCTTCTTAGAGCTGTTAAGTCTAAGGT
GTGGCAGAGCAGACAGAGATAGAGGCATCTGAAGTGAGTATAGGTTTTTTGACTAAGAAAAAAAACAACAGCAAACATGACTAGTGATCT
TGAAATATTTTGTACCGAGAGAAAGACTGCATTTATTTGTAGAATTTATCAGGTTTCTGATACCACTCATTGGATGTAAACATTTCATGT
TTCCTCACTTTTGATATGAAAGTCGGTAAAATGCAGTATTAGTCCCGGGAGGATGTGCACAGCTGGTCAGAGCTTCCAGAAGGAATATCT
TCCGAGGACTAAGGTGATCAGGTTAAGAGGGTTCAACATCCCACGGCCCTCACCTTCCTCCCTCCCACATTCCAGGCATGGAGATATCTG
GTTTCAGAGTCAGCCCCAAATCTCCTGCCTATAATTACTTTAACTGGGGTCTCTAAGGTTCCCACTTGAGGGCTAAAATGTAGTTGGGAA
AGAGGGCCTACTGGGGAGGTCTCACAGGAGGCAGTGCCCTGGGAAATGCCAAGTCCAGACTCAGTGCCAAGCAGTAACCATCTGCACTCG
GGGACAGCGAGGAGCTGACCATGGCCTCTGATGACCAGCAGGTATTAGATGGAAGTGAATGAGAGAGAGAGAGAGAGAGAGTATGTGTGT
GTGTGTGTATGTGTGTGTTCGAACACATATGATTGCCAGTATGGAGAATGAAAGATTAATAATGCTTTCTGGAGAGTTTGATGCAAAAGT
GGGGGAAACGGAGAAAAGGCGCTAAGGCTAAATCCATCTGCATTTGCTATATTTCATTAGCTAAAGTCAGGTCAGGGCAGGGCCAAGGCC
TCCAATTGGCAAAGGACAGTGTTATGGCTTTAAAAAGCTGAAACCCCAACCTCTAAGTAGATCACAATGTTTTCTGAGCTTTGCAGTAAT
TTTCTATGGAAACTAAAACCTCTAAAACATACAAGCTGGCCCAAATGAGAACACAAGCAAAAGATGTGGAAGACAGCAAAACCTGAGCAC
TGGTTTGAACCAGGCACTGACATTTGAAATGCTTTAAGCCTTTTCACATTCCTTCTTTATTCCCTCCAAAAAAAAAAGTCTTGAGTTTAA
TTTAGGTCTATTTTGGCTGAGATTAGCATACCTCTGACTCACAGGATTTAATAAATTATAGTATTATTGAATACATAGGACATCCCTCTA
CCCCAGCTTACTCTTATCTTTTTAATTTAAAATAGTATTCTGCTACCAAGAAGGATGCAACTGCTAGTTTTAGATGTAAATAGTGTTATT
TACTGGACTTTGTGATATTATTTTCTTAACTACACTTTACTATGGCCCTGTTGAAAACAGACTATCAAGTTTTTTGTCTCTGTTCTGTCA
TCTCTCTTAAGCCAGGCACCTTTAGAGTGTTTGCAATTTGTTCGAAGTGGTTGAGGATCTCAGGCCCTGCTCACGTGAGGTGGAGTGCAG
GGGAGCTACCGGTTTCCCTGCTGACCTGCTGAATGCTACCTTCCCCTCGAGTTGAATACACCTTAAGGAAAATGATAACACGAGGGACGT
GTAACTTGTTTTGAAGCATTAAAAACCAGCAGCTCTTCACTATGTTCCATATTTTAACCAAACTACTGTAGACTACTAAACATAGCCAAG
CCAGAACATTCCTTCTGGATTAAGCCTAGGCCACTTGAGGGGCAGCCAGGGGTGATGGTGTCAGGTGAGAATCCTGTGTCTTGAAGGAGT
GGCCTTTACAGGAAGAGTGCCCATGTTTTCACCTGCAGCGTTGCCACCAGAGTGTGCAATACCTCCTGCACACAGGCTCAGGGTAAACTG
CTCCAAAGCTGGGTTTTGTGTTGCATACAAAGTCAATAAAATAGTTGCTAATCCTGAATGGCAGCCAGTGATGTGAAGGTACTATTAAAG
TGAACAAAAACTAGATTGCAACAGTTTTCTTTCCTTGCTTGAAGTATAACACACGCTCCATTTGATCCTGCCTGAAAGAAGCTAACATTA
TATTTGTGACAGACAGAGGCTCCATCAAGCCAAGCAACAATTAACAGCTCAAGTGTAAGATTTATAAATGCCCGTGTACTCACCCTTCAA
TTGTTACCACCCAGAGGTTACAGGACTCTTTCCCAGCATTTAGGGGAACAGGCTTTTAGAGTATTTAGAAGACCAGGCTATAATCAGTAA
TGTGCCTGGGAGCAGGAAATAGCTCCCAATTTATTTATGGCCTTGGGAAAACTCAATCCGGTGTCTCCTTGTAGCTCAGAACACTAATAG
CCCCCCTGGAAGAGAGTGGCACATTGAGCTCCAAACCCAATCAACATACATCCACTTGGCTGCAGATCTGACTGCTGGGTCATGAAGGCC
GTGAAATGATGTTTGCCCTCAAGTCACTAGATATTTTAAGAAGCCCTATTTTTCTCCCTTTTTGCAGGAGTAGAGAGATGAAAGAGGACA
GACCATTGAAAACTTTTAGATGCAGGAGAATTGAGACTTCCACAAGGGAGAGAAACACAGCCTCCCCAGAATCCATTATGCCATCGGGTT
GTGGCACTCTCACCCTTGCCATAATACCGTTTCCTAACAATATCAAATCAGTGGATGAAATACAAGCTCAGAAACAGGAACATTTTCCTA
AATCATAACCTAATAGCAAACAAAAATTGAAAAAACAATTATTCTGAAGCTCATTATTCTTAGATCTGTAGATATATATGTGTTGACTCC
CACAGGATGGCACCAAGTAAAGATCTTAAGAGCATAGTAGGGGTTCTGAGACCGACTGTCACCCGTGGATCCTGATGGGGAAGAACAGAG
GCTTCACTGTAGCTATAGTTTTCCACCAAGTCAATCAAATTAAAACATGACTCATTGTCCCCTCCAAAGATTCATAAAATTCTTGAGCTA
AAGTGATCTTCTGAAGAAAAGCCACCTAACAATGTTAGGAGGCTCATAAAGCTCATTTCTCTTTTCCCTGGTATGCACAAATATCAAGCC
TATAAAAAAGTAATTATTTCCCCAAACCTGTAACCACTGCATTCGTTTTCTTTGGAGGAACATTGTAGCATTTCAGGAGGGTCGAGAGAT
CTAAAGAGTTTGGTCTGAATGTGTGTCTGTACAATTCCCTTTGGCATTAAACTCTGAAACCTACAATCAATGGCCTTCAAATTGGTGTTA
AATTGGGAGAACACCCTACTGCTTTCTGAGTCTACGAGCAACAGAAAGACTGGTCTTAGTGCAATTAGGCAGGAGGGATTTGGACTCAGA
AACAGCCACAGAAGTATTTCTCAGCACTCCCAGTTCCTGCCAACTTAGCTGGAAACGATGCCACAGCGAGACCAGAAAGAGGAGTCGCCT
TAAGGTATCCCTACAAAGTCACCTTTCTGATAAAAAGGAGGGAAAAAAAAGTTAGATATCTAAAATAAGCCTAGAATCTCACACACAGCT
GTGACTTCTAAGTGAAACTCTTTTCTCCCTCATGTCCTTAAATAGTCACAGAATCACACACAGCCTGACTTTTAAAGACAAGCTTGGCTA
CAGGAAATGAACCAACCCCAAAGACTCTTCTAACCTGTCTCCTGACTGGGCTCCTTCAGAAAGTGTTCTCCTGTTCCATCTGTAGGGCTG
CTTACTACTGGAACCTAAAACAAAACCTGTTGTTTGTACCATCACTTTTTCTGGTGTTTCCTGTGCTTTTGTGATTCCAAGTCTGTTCAT
AAGTTCTGAAGATAAATTATGTGAAATCATATTTTGGCATATGGGGGTGGAGGATGAATTCTTTACAGACTTTTTAAGATGATCCATTTG
TACCACAGAAAACATTTTGGAAGTTGTTATATATGAGTATATAAATTTTTCTTTTCATATTTTACATTAAAATAAAGCTTTATTCAGTCA

>9936_9936_4_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374574_PARD3B_chr2_206110501_ENST00000406610_length(amino acids)=522AA_BP=30
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVR
GRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDP
ERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNY
ARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLRKEYYQARREGFPL
YEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR

--------------------------------------------------------------
>9936_9936_5_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374574_PARD3B_chr2_206110501_ENST00000462231_length(transcript)=785nt_BP=117nt
ATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGA
CCATCCTGCTGGTCAGCACTGCGGCTGTGCCAGATGAAAGCAAGGTTCACTCATTGGCTGGACAAAAATCGGAATCTCCAAGCAAAGATT
TTGGTCCAACTCTGGGTTTGAAAAAGTCCAGCTCCTTGGAGAGTCTGCAGACTGCAGTGGCCGAGGTCAGGAAGAATGACCTTCCCTTTC
ACAGGCCCCGGCCGCACATGGTTCGAGGCCGAGGCTGCAATGAGAGCTTTAGAGCAGCCATTGACAAATCCTACGATGGACCTGAAGAAA
TAGAAGCTGACGGTCTGTCTGATAAGAGCTCTCACTCTGGCCAAGGAGCTCTGAATTGTGAGTCTGCCCCTCAGGGGAATTCGGAGCTAG
AGGACATGGAAAATAAAGCCAGGAAAGTCAAAAAAACGAAAGAGAAGGAGAAGAAAAAGGAAAAGGGCAAATTGAAAGTCAAGGAGAAAA
AGCGCAAAGAGGAGAATGAAGATCCAGAAAGGAAAATAAAGAAGAAGGGCTTCGGCGCCATGCTGAGGTATGGGCCTGCTTTGAAGGCAA
AGTTGGTTCTCATTTTGTCTCTCCTGAAAAAAGCGCACGCTTTTCCTCGTCTTCAGCCAAATGCATACGGCTCTCAATTCTGTGCTCGTT

>9936_9936_5_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374574_PARD3B_chr2_206110501_ENST00000462231_length(amino acids)=253AA_BP=30
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVR
GRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDP

--------------------------------------------------------------
>9936_9936_6_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374580_PARD3B_chr2_206110501_ENST00000349953_length(transcript)=1790nt_BP=615nt
GGAAGCACCGAAGCGAAACTTAAGGAATCCTGCCTTCCCGGAGCCGCGGGCGATGCGACTAGGGCTGCCGGGCGCCGCCGCCGCCCGTCC
GGCTTCGTCCTTCCCGGCAGTCGGGAACTAGTTCTGACCCTCGCCCCCCGACCCCGGATCGAATCCCCGCCCTCCGCACCCTGGATATGT
TTTCTCCCAGACCTGGATATTTTTTTGATATCGTGAAACTACGAGGGAAATAATTTGGGGGATTTCTTCTTGGCTCCCTGCTTTCCCCAC
AGACATGCCTTCCGTTTGGAGGGCCGCGGCACCCCGTCCGAGGCGAAGGAACCCCCCCAGCCGCGAGGGAGAGAAATGAAGGGAATTTCT
GCAGCGGCATGAAAGCTCTGCAGCTAGGTCCTCTCATCAGCCATTTGTCCTTTCAAACTGTATTGTGATACGGGCAGGATCAGTCCACGG
GAGAGAAGACGAGCCTCCCGGCTGTTTCTCCGCCGGTCTACTTCCCATATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGA
TGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGACCATCCTGCTGGTCAGCACTGCGGCTGTGCCAGATGAAAGCA
AGGTTCACTCATTGGCTGGACAAAAATCGGAATCTCCAAGCAAAGATTTTGGTCCAACTCTGGGTTTGAAAAAGTCCAGCTCCTTGGAGA
GTCTGCAGACTGCAGTGGCCGAGGTCAGGAAGAATGACCTTCCCTTTCACAGGCCCCGGCCGCACATGGTTCGAGGCCGAGGCTGCAATG
AGAGCTTTAGAGCAGCCATTGACAAATCCTACGATGGACCTGAAGAAATAGAAGCTGACGGTCTGTCTGATAAGAGCTCTCACTCTGGCC
AAGGAGCTCTGAATTGTGAGTCTGCCCCTCAGGGGAATTCGGAGCTAGAGGACATGGAAAATAAAGCCAGGAAAGTCAAAAAAACGAAAG
AGAAGGAGAAGAAAAAGGAAAAGGGCAAATTGAAAGTCAAGGAGAAAAAGCGCAAAGAGGAGAATGAAGATCCAGAAAGGAAAATAAAGA
AGAAGGGCTTCGGCGCCATGCTGAGATTTGGAAAGAAGAAAGAGGATAAGGGTGGAAAGGCTGAGCAGAAAGGTACTCTGAAACATGGTG
GCCTGAGAGAAGAAGAGCTGGAGAAAATGAAAGAAGAGCGTGAAAGTGGCCGTCCTACGGGTGGAAGCACTGACCGTATCCAGAAGTTGC
GGAAAGAGTATTATCAGGCTCGGAGGGAAGGTTTCCCTTTATATGAAGACGACGAAGGAAGAGCAAGGCCATCTGAGTATGACCTACTCT
GGGTGCCTGGAAGGGGTCCAGATGGGAATGCACACAACCTCCGCTTTGAAGGGATGGAGAGGCAGTACGCATCCTTACCCAGGGGAGGAC
CCGCAGATCCTGTAGACTATCTGCCAGCAGCACCTCGGGGGCTCTACAAGGAAAGGGAGCTTCCCTATTATCCAGGGGCTCATCCTATGC
ACCCTCCCAAAGGGAGCTATCCCCGCCCCACAGAGCTCAGGGTGGCAGATCTCCGGTATCCTCAGCACTACCCACCCCCGCCAGCTCCCC
AGCACAAAGGACCCTTTCGACAAGACGTTCCGCCTTCCCCTCCCCAGCACCAAAGAATGCCAGCCTATCAGGAAACAGGCAGACCAGGGC

>9936_9936_6_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374580_PARD3B_chr2_206110501_ENST00000349953_length(amino acids)=422AA_BP=30
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVR
GRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDP
ERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPS
EYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYPQHYP

--------------------------------------------------------------
>9936_9936_7_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374580_PARD3B_chr2_206110501_ENST00000351153_length(transcript)=1886nt_BP=615nt
GGAAGCACCGAAGCGAAACTTAAGGAATCCTGCCTTCCCGGAGCCGCGGGCGATGCGACTAGGGCTGCCGGGCGCCGCCGCCGCCCGTCC
GGCTTCGTCCTTCCCGGCAGTCGGGAACTAGTTCTGACCCTCGCCCCCCGACCCCGGATCGAATCCCCGCCCTCCGCACCCTGGATATGT
TTTCTCCCAGACCTGGATATTTTTTTGATATCGTGAAACTACGAGGGAAATAATTTGGGGGATTTCTTCTTGGCTCCCTGCTTTCCCCAC
AGACATGCCTTCCGTTTGGAGGGCCGCGGCACCCCGTCCGAGGCGAAGGAACCCCCCCAGCCGCGAGGGAGAGAAATGAAGGGAATTTCT
GCAGCGGCATGAAAGCTCTGCAGCTAGGTCCTCTCATCAGCCATTTGTCCTTTCAAACTGTATTGTGATACGGGCAGGATCAGTCCACGG
GAGAGAAGACGAGCCTCCCGGCTGTTTCTCCGCCGGTCTACTTCCCATATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGA
TGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGACCATCCTGCTGGTCAGCACTGCGGCTGTGCCAGATGAAAGCA
AGGTTCACTCATTGGCTGGACAAAAATCGGACGGTCTGTCTGATAAGAGCTCTCACTCTGGCCAAGGAGCTCTGAATTGTGAGTCTGCCC
CTCAGGGGAATTCGGAGCTAGAGGACATGGAAAATAAAGCCAGGAAAGTCAAAAAAACGAAAGAGAAGGAGAAGAAAAAGGAAAAGGGCA
AATTGAAAGTCAAGGAGAAAAAGCGCAAAGAGGAGAATGAAGATCCAGAAAGGAAAATAAAGAAGAAGGGCTTCGGCGCCATGCTGAGAT
TTGGAAAGAAGAAAGAGGATAAGGGTGGAAAGGCTGAGCAGAAAGGTACTCTGAAACATGGTGGCCTGAGAGAAGAAGAGCTGGAGAAAA
TGAAAGAAGAGCGTGAAAGGATTGGAGCAAAACATCAGGAGCTAAGGGAAAAGCAGGCAAGAGGTCTTCTTGATTATGCTACTGGTGCAA
TTGGATCAGTGTATGATATGGATGATGATGAAATGGACCCCAATTATGCCAGAGTGAACCACTTTCGGGAACCATGCACATCAGCAAATG
TCTTTAGATCTCCATCTCCCCCTCGAGCTGGACCATTTGGTTACCCTCGGGATGGCCATCCACTGTCTCCAGAAAGAGACCACTTAGAGG
GTCTCTATGCCAAGGTCAACAAGCCATACCATCCACTGGTTCCAGCTGACAGTGGCCGTCCTACGGGTGGAAGCACTGACCGTATCCAGA
AGTTGCGGAAAGAGTATTATCAGGCTCGGAGGGAAGGTTTCCCTTTATATGAAGACGACGAAGGAAGAGCAAGGCCATCTGAGTATGACC
TACTCTGGGTGCCTGGAAGGGGTCCAGATGGGAATGCACACAACCTCCGCTTTGAAGGGATGGAGAGGCAGTACGCATCCTTACCCAGGG
GAGGACCCGCAGATCCTGTAGACTATCTGCCAGCAGCACCTCGGGGGCTCTACAAGGAAAGGGAGCTTCCCTATTATCCAGGGGCTCATC
CTATGCACCCTCCCAAAGGGAGCTATCCCCGCCCCACAGAGCTCAGGGTGGCAGATCTCCGGTATCCTCAGCACTACCCACCCCCGCCAG
CTCCCCAGCACAAAGGACCCTTTCGACAAGACGTTCCGCCTTCCCCTCCCCAGCACCAAAGAATGCCAGCCTATCAGGAAACAGGCAGAC

>9936_9936_7_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374580_PARD3B_chr2_206110501_ENST00000351153_length(amino acids)=454AA_BP=30
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAVPDESKVHSLAGQKSDGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEK
KKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQARGLLD
YATGAIGSVYDMDDDEMDPNYARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGS
TDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPY
YPGAHPMHPPKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNPMT

--------------------------------------------------------------
>9936_9936_8_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374580_PARD3B_chr2_206110501_ENST00000358768_length(transcript)=2093nt_BP=615nt
GGAAGCACCGAAGCGAAACTTAAGGAATCCTGCCTTCCCGGAGCCGCGGGCGATGCGACTAGGGCTGCCGGGCGCCGCCGCCGCCCGTCC
GGCTTCGTCCTTCCCGGCAGTCGGGAACTAGTTCTGACCCTCGCCCCCCGACCCCGGATCGAATCCCCGCCCTCCGCACCCTGGATATGT
TTTCTCCCAGACCTGGATATTTTTTTGATATCGTGAAACTACGAGGGAAATAATTTGGGGGATTTCTTCTTGGCTCCCTGCTTTCCCCAC
AGACATGCCTTCCGTTTGGAGGGCCGCGGCACCCCGTCCGAGGCGAAGGAACCCCCCCAGCCGCGAGGGAGAGAAATGAAGGGAATTTCT
GCAGCGGCATGAAAGCTCTGCAGCTAGGTCCTCTCATCAGCCATTTGTCCTTTCAAACTGTATTGTGATACGGGCAGGATCAGTCCACGG
GAGAGAAGACGAGCCTCCCGGCTGTTTCTCCGCCGGTCTACTTCCCATATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGA
TGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGACCATCCTGCTGGTCAGCACTGCGGCTGTGCCAGATGAAAGCA
AGGTTCACTCATTGGCTGGACAAAAATCGGAATCTCCAAGCAAAGATTTTGGTCCAACTCTGGGTTTGAAAAAGTCCAGCTCCTTGGAGA
GTCTGCAGACTGCAGTGGCCGAGGTCAGGAAGAATGACCTTCCCTTTCACAGGCCCCGGCCGCACATGGTTCGAGGCCGAGGCTGCAATG
AGAGCTTTAGAGCAGCCATTGACAAATCCTACGATGGACCTGAAGAAATAGAAGCTGACGGTCTGTCTGATAAGAGCTCTCACTCTGGCC
AAGGAGCTCTGAATTGTGAGTCTGCCCCTCAGGGGAATTCGGAGCTAGAGGACATGGAAAATAAAGCCAGGAAAGTCAAAAAAACGAAAG
AGAAGGAGAAGAAAAAGGAAAAGGGCAAATTGAAAGTCAAGGAGAAAAAGCGCAAAGAGGAGAATGAAGATCCAGAAAGGAAAATAAAGA
AGAAGGGCTTCGGCGCCATGCTGAGATTTGGAAAGAAGAAAGAGGATAAGGGTGGAAAGGCTGAGCAGAAAGGTACTCTGAAACATGGTG
GCCTGAGAGAAGAAGAGCTGGAGAAAATGAAAGAAGAGCGTGAAAGGATTGGAGCAAAACATCAGGAGCTAAGGGAAAAGCAGGCAAGAG
GTCTTCTTGATTATGCTACTGGTGCAATTGGATCAGTGTATGATATGGATGATGATGAAATGGACCCCAATTATGCCAGAGTGAACCACT
TTCGGGAACCATGCACATCAGCAAATGTCTTTAGATCTCCATCTCCCCCTCGAGCTGGACCATTTGGTTACCCTCGGGATGGCCATCCAC
TGTCTCCAGAAAGAGACCACTTAGAGGGTCTCTATGCCAAGGTCAACAAGCCATACCATCCACTGGTTCCAGCTGACAGTGGCCGTCCTA
CGGGTGGAAGCACTGACCGTATCCAGAAGTTGCGGAAAGAGTATTATCAGGCTCGGAGGGAAGGTTTCCCTTTATATGAAGACGACGAAG
GAAGAGCAAGGCCATCTGAGTATGACCTACTCTGGGTGCCTGGAAGGGGTCCAGATGGGAATGCACACAACCTCCGCTTTGAAGGGATGG
AGAGGCAGTACGCATCCTTACCCAGGGGAGGACCCGCAGATCCTGTAGACTATCTGCCAGCAGCACCTCGGGGGCTCTACAAGGAAAGGG
AGCTTCCCTATTATCCAGGGGCTCATCCTATGCACCCTCCCAAAGGGAGCTATCCCCGCCCCACAGAGCTCAGGGTGGCAGATCTCCGGT
ATCCTCAGCACTACCCACCCCCGCCAGCTCCCCAGCACAAAGGACCCTTTCGACAAGACGTTCCGCCTTCCCCTCCCCAGCACCAAAGAA
TGCCAGCCTATCAGGAAACAGGCAGACCAGGGCCCCGTGGGGGCAGCCCAGACCAGTACCCTTACCGAACCCAGGATTCCCGGCAGAAGA

>9936_9936_8_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374580_PARD3B_chr2_206110501_ENST00000358768_length(amino acids)=523AA_BP=30
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVR
GRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDP
ERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNY
ARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLRKEYYQARREGFPL
YEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR

--------------------------------------------------------------
>9936_9936_9_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374580_PARD3B_chr2_206110501_ENST00000406610_length(transcript)=6442nt_BP=615nt
GGAAGCACCGAAGCGAAACTTAAGGAATCCTGCCTTCCCGGAGCCGCGGGCGATGCGACTAGGGCTGCCGGGCGCCGCCGCCGCCCGTCC
GGCTTCGTCCTTCCCGGCAGTCGGGAACTAGTTCTGACCCTCGCCCCCCGACCCCGGATCGAATCCCCGCCCTCCGCACCCTGGATATGT
TTTCTCCCAGACCTGGATATTTTTTTGATATCGTGAAACTACGAGGGAAATAATTTGGGGGATTTCTTCTTGGCTCCCTGCTTTCCCCAC
AGACATGCCTTCCGTTTGGAGGGCCGCGGCACCCCGTCCGAGGCGAAGGAACCCCCCCAGCCGCGAGGGAGAGAAATGAAGGGAATTTCT
GCAGCGGCATGAAAGCTCTGCAGCTAGGTCCTCTCATCAGCCATTTGTCCTTTCAAACTGTATTGTGATACGGGCAGGATCAGTCCACGG
GAGAGAAGACGAGCCTCCCGGCTGTTTCTCCGCCGGTCTACTTCCCATATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGA
TGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGACCATCCTGCTGGTCAGCACTGCGGCTGTGCCAGATGAAAGCA
AGGTTCACTCATTGGCTGGACAAAAATCGGAATCTCCAAGCAAAGATTTTGGTCCAACTCTGGGTTTGAAAAAGTCCAGCTCCTTGGAGA
GTCTGCAGACTGCAGTGGCCGAGGTCAGGAAGAATGACCTTCCCTTTCACAGGCCCCGGCCGCACATGGTTCGAGGCCGAGGCTGCAATG
AGAGCTTTAGAGCAGCCATTGACAAATCCTACGATGGACCTGAAGAAATAGAAGCTGACGGTCTGTCTGATAAGAGCTCTCACTCTGGCC
AAGGAGCTCTGAATTGTGAGTCTGCCCCTCAGGGGAATTCGGAGCTAGAGGACATGGAAAATAAAGCCAGGAAAGTCAAAAAAACGAAAG
AGAAGGAGAAGAAAAAGGAAAAGGGCAAATTGAAAGTCAAGGAGAAAAAGCGCAAAGAGGAGAATGAAGATCCAGAAAGGAAAATAAAGA
AGAAGGGCTTCGGCGCCATGCTGAGATTTGGAAAGAAGAAAGAGGATAAGGGTGGAAAGGCTGAGCAGAAAGGTACTCTGAAACATGGTG
GCCTGAGAGAAGAAGAGCTGGAGAAAATGAAAGAAGAGCGTGAAAGGATTGGAGCAAAACATCAGGAGCTAAGGGAAAAGCAGGCAAGAG
GTCTTCTTGATTATGCTACTGGTGCAATTGGATCAGTGTATGATATGGATGATGATGAAATGGACCCCAATTATGCCAGAGTGAACCACT
TTCGGGAACCATGCACATCAGCAAATGTCTTTAGATCTCCATCTCCCCCTCGAGCTGGACCATTTGGTTACCCTCGGGATGGCCATCCAC
TGTCTCCAGAAAGAGACCACTTAGAGGGTCTCTATGCCAAGGTCAACAAGCCATACCATCCACTGGTTCCAGCTGACAGTGGCCGTCCTA
CGGGTGGAAGCACTGACCGTATCCAGAAGTTGCGGAAAGAGTATTATCAGGCTCGGAGGGAAGGTTTCCCTTTATATGAAGACGACGAAG
GAAGAGCAAGGCCATCTGAGTATGACCTACTCTGGGTGCCTGGAAGGGGTCCAGATGGGAATGCACACAACCTCCGCTTTGAAGGGATGG
AGAGGCAGTACGCATCCTTACCCAGGGGAGGACCCGCAGATCCTGTAGACTATCTGCCAGCAGCACCTCGGGGGCTCTACAAGGAAAGGG
AGCTTCCCTATTATCCAGGGGCTCATCCTATGCACCCTCCCAAAGGGAGCTATCCCCGCCCCACAGAGCTCAGGGTGGCAGATCTCCGGT
ATCCTCAGCACTACCCACCCCCGCCAGCTCCCCAGCACAAAGGACCCTTTCGACAAGACGTTCCGCCTTCCCCTCCCCAGCACCAAAGAA
TGCCAGCCTATCAGGAAACAGGCAGACCAGGGCCCCGTGGGGGCAGCCCAGACCAGTACCCTTACCGAACCCAGGATTCCCGGCAGAAGA
ACCCCATGACTGCAGCCGTATAGCTGAGTGCCACCGAGGCCAGCCCGGTCCAGAAAGGAAGGTGTCTACTCTACCTTTGCCCTTTCTAAA
CCTGAAGACCTCCTTGGTGTTAGGAATTCTCCATGTTACTGATAAGCTTTTTCTCACTGACATTGTAACGCATGACTGCTAATCAGAGAG
AAAAAGAAGGGGAAGGGAATTGGGGAGGAAAAAAAATCAGAAGGAAGACGAAAGATGGGGCTATAAAAACAAAACTACCTGATAGTTGAA
ACGCTTTCAGAGTTGTTCAAATCAGTGAGAGTGGCAACGGAACACACAAACAACTAATTATGGAACTCTACTCTGGGGATCCTCTCTGGC
TAGATAACCTGTGCTGATGTGCAGACACGTGGACATCCCCCTCTGAGACTGGCGGTCCAGAGGCAGTCTCTGCCAGGCAGCATTACCCGC
TCCGAGGTGGAGCCTCAGCCCCCTTCTTAGAGCTGTTAAGTCTAAGGTGTGGCAGAGCAGACAGAGATAGAGGCATCTGAAGTGAGTATA
GGTTTTTTGACTAAGAAAAAAAACAACAGCAAACATGACTAGTGATCTTGAAATATTTTGTACCGAGAGAAAGACTGCATTTATTTGTAG
AATTTATCAGGTTTCTGATACCACTCATTGGATGTAAACATTTCATGTTTCCTCACTTTTGATATGAAAGTCGGTAAAATGCAGTATTAG
TCCCGGGAGGATGTGCACAGCTGGTCAGAGCTTCCAGAAGGAATATCTTCCGAGGACTAAGGTGATCAGGTTAAGAGGGTTCAACATCCC
ACGGCCCTCACCTTCCTCCCTCCCACATTCCAGGCATGGAGATATCTGGTTTCAGAGTCAGCCCCAAATCTCCTGCCTATAATTACTTTA
ACTGGGGTCTCTAAGGTTCCCACTTGAGGGCTAAAATGTAGTTGGGAAAGAGGGCCTACTGGGGAGGTCTCACAGGAGGCAGTGCCCTGG
GAAATGCCAAGTCCAGACTCAGTGCCAAGCAGTAACCATCTGCACTCGGGGACAGCGAGGAGCTGACCATGGCCTCTGATGACCAGCAGG
TATTAGATGGAAGTGAATGAGAGAGAGAGAGAGAGAGAGTATGTGTGTGTGTGTGTATGTGTGTGTTCGAACACATATGATTGCCAGTAT
GGAGAATGAAAGATTAATAATGCTTTCTGGAGAGTTTGATGCAAAAGTGGGGGAAACGGAGAAAAGGCGCTAAGGCTAAATCCATCTGCA
TTTGCTATATTTCATTAGCTAAAGTCAGGTCAGGGCAGGGCCAAGGCCTCCAATTGGCAAAGGACAGTGTTATGGCTTTAAAAAGCTGAA
ACCCCAACCTCTAAGTAGATCACAATGTTTTCTGAGCTTTGCAGTAATTTTCTATGGAAACTAAAACCTCTAAAACATACAAGCTGGCCC
AAATGAGAACACAAGCAAAAGATGTGGAAGACAGCAAAACCTGAGCACTGGTTTGAACCAGGCACTGACATTTGAAATGCTTTAAGCCTT
TTCACATTCCTTCTTTATTCCCTCCAAAAAAAAAAGTCTTGAGTTTAATTTAGGTCTATTTTGGCTGAGATTAGCATACCTCTGACTCAC
AGGATTTAATAAATTATAGTATTATTGAATACATAGGACATCCCTCTACCCCAGCTTACTCTTATCTTTTTAATTTAAAATAGTATTCTG
CTACCAAGAAGGATGCAACTGCTAGTTTTAGATGTAAATAGTGTTATTTACTGGACTTTGTGATATTATTTTCTTAACTACACTTTACTA
TGGCCCTGTTGAAAACAGACTATCAAGTTTTTTGTCTCTGTTCTGTCATCTCTCTTAAGCCAGGCACCTTTAGAGTGTTTGCAATTTGTT
CGAAGTGGTTGAGGATCTCAGGCCCTGCTCACGTGAGGTGGAGTGCAGGGGAGCTACCGGTTTCCCTGCTGACCTGCTGAATGCTACCTT
CCCCTCGAGTTGAATACACCTTAAGGAAAATGATAACACGAGGGACGTGTAACTTGTTTTGAAGCATTAAAAACCAGCAGCTCTTCACTA
TGTTCCATATTTTAACCAAACTACTGTAGACTACTAAACATAGCCAAGCCAGAACATTCCTTCTGGATTAAGCCTAGGCCACTTGAGGGG
CAGCCAGGGGTGATGGTGTCAGGTGAGAATCCTGTGTCTTGAAGGAGTGGCCTTTACAGGAAGAGTGCCCATGTTTTCACCTGCAGCGTT
GCCACCAGAGTGTGCAATACCTCCTGCACACAGGCTCAGGGTAAACTGCTCCAAAGCTGGGTTTTGTGTTGCATACAAAGTCAATAAAAT
AGTTGCTAATCCTGAATGGCAGCCAGTGATGTGAAGGTACTATTAAAGTGAACAAAAACTAGATTGCAACAGTTTTCTTTCCTTGCTTGA
AGTATAACACACGCTCCATTTGATCCTGCCTGAAAGAAGCTAACATTATATTTGTGACAGACAGAGGCTCCATCAAGCCAAGCAACAATT
AACAGCTCAAGTGTAAGATTTATAAATGCCCGTGTACTCACCCTTCAATTGTTACCACCCAGAGGTTACAGGACTCTTTCCCAGCATTTA
GGGGAACAGGCTTTTAGAGTATTTAGAAGACCAGGCTATAATCAGTAATGTGCCTGGGAGCAGGAAATAGCTCCCAATTTATTTATGGCC
TTGGGAAAACTCAATCCGGTGTCTCCTTGTAGCTCAGAACACTAATAGCCCCCCTGGAAGAGAGTGGCACATTGAGCTCCAAACCCAATC
AACATACATCCACTTGGCTGCAGATCTGACTGCTGGGTCATGAAGGCCGTGAAATGATGTTTGCCCTCAAGTCACTAGATATTTTAAGAA
GCCCTATTTTTCTCCCTTTTTGCAGGAGTAGAGAGATGAAAGAGGACAGACCATTGAAAACTTTTAGATGCAGGAGAATTGAGACTTCCA
CAAGGGAGAGAAACACAGCCTCCCCAGAATCCATTATGCCATCGGGTTGTGGCACTCTCACCCTTGCCATAATACCGTTTCCTAACAATA
TCAAATCAGTGGATGAAATACAAGCTCAGAAACAGGAACATTTTCCTAAATCATAACCTAATAGCAAACAAAAATTGAAAAAACAATTAT
TCTGAAGCTCATTATTCTTAGATCTGTAGATATATATGTGTTGACTCCCACAGGATGGCACCAAGTAAAGATCTTAAGAGCATAGTAGGG
GTTCTGAGACCGACTGTCACCCGTGGATCCTGATGGGGAAGAACAGAGGCTTCACTGTAGCTATAGTTTTCCACCAAGTCAATCAAATTA
AAACATGACTCATTGTCCCCTCCAAAGATTCATAAAATTCTTGAGCTAAAGTGATCTTCTGAAGAAAAGCCACCTAACAATGTTAGGAGG
CTCATAAAGCTCATTTCTCTTTTCCCTGGTATGCACAAATATCAAGCCTATAAAAAAGTAATTATTTCCCCAAACCTGTAACCACTGCAT
TCGTTTTCTTTGGAGGAACATTGTAGCATTTCAGGAGGGTCGAGAGATCTAAAGAGTTTGGTCTGAATGTGTGTCTGTACAATTCCCTTT
GGCATTAAACTCTGAAACCTACAATCAATGGCCTTCAAATTGGTGTTAAATTGGGAGAACACCCTACTGCTTTCTGAGTCTACGAGCAAC
AGAAAGACTGGTCTTAGTGCAATTAGGCAGGAGGGATTTGGACTCAGAAACAGCCACAGAAGTATTTCTCAGCACTCCCAGTTCCTGCCA
ACTTAGCTGGAAACGATGCCACAGCGAGACCAGAAAGAGGAGTCGCCTTAAGGTATCCCTACAAAGTCACCTTTCTGATAAAAAGGAGGG
AAAAAAAAGTTAGATATCTAAAATAAGCCTAGAATCTCACACACAGCTGTGACTTCTAAGTGAAACTCTTTTCTCCCTCATGTCCTTAAA
TAGTCACAGAATCACACACAGCCTGACTTTTAAAGACAAGCTTGGCTACAGGAAATGAACCAACCCCAAAGACTCTTCTAACCTGTCTCC
TGACTGGGCTCCTTCAGAAAGTGTTCTCCTGTTCCATCTGTAGGGCTGCTTACTACTGGAACCTAAAACAAAACCTGTTGTTTGTACCAT
CACTTTTTCTGGTGTTTCCTGTGCTTTTGTGATTCCAAGTCTGTTCATAAGTTCTGAAGATAAATTATGTGAAATCATATTTTGGCATAT
GGGGGTGGAGGATGAATTCTTTACAGACTTTTTAAGATGATCCATTTGTACCACAGAAAACATTTTGGAAGTTGTTATATATGAGTATAT

>9936_9936_9_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374580_PARD3B_chr2_206110501_ENST00000406610_length(amino acids)=522AA_BP=30
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVR
GRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDP
ERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNY
ARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLRKEYYQARREGFPL
YEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR

--------------------------------------------------------------
>9936_9936_10_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374580_PARD3B_chr2_206110501_ENST00000462231_length(transcript)=1283nt_BP=615nt
GGAAGCACCGAAGCGAAACTTAAGGAATCCTGCCTTCCCGGAGCCGCGGGCGATGCGACTAGGGCTGCCGGGCGCCGCCGCCGCCCGTCC
GGCTTCGTCCTTCCCGGCAGTCGGGAACTAGTTCTGACCCTCGCCCCCCGACCCCGGATCGAATCCCCGCCCTCCGCACCCTGGATATGT
TTTCTCCCAGACCTGGATATTTTTTTGATATCGTGAAACTACGAGGGAAATAATTTGGGGGATTTCTTCTTGGCTCCCTGCTTTCCCCAC
AGACATGCCTTCCGTTTGGAGGGCCGCGGCACCCCGTCCGAGGCGAAGGAACCCCCCCAGCCGCGAGGGAGAGAAATGAAGGGAATTTCT
GCAGCGGCATGAAAGCTCTGCAGCTAGGTCCTCTCATCAGCCATTTGTCCTTTCAAACTGTATTGTGATACGGGCAGGATCAGTCCACGG
GAGAGAAGACGAGCCTCCCGGCTGTTTCTCCGCCGGTCTACTTCCCATATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGA
TGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGACCATCCTGCTGGTCAGCACTGCGGCTGTGCCAGATGAAAGCA
AGGTTCACTCATTGGCTGGACAAAAATCGGAATCTCCAAGCAAAGATTTTGGTCCAACTCTGGGTTTGAAAAAGTCCAGCTCCTTGGAGA
GTCTGCAGACTGCAGTGGCCGAGGTCAGGAAGAATGACCTTCCCTTTCACAGGCCCCGGCCGCACATGGTTCGAGGCCGAGGCTGCAATG
AGAGCTTTAGAGCAGCCATTGACAAATCCTACGATGGACCTGAAGAAATAGAAGCTGACGGTCTGTCTGATAAGAGCTCTCACTCTGGCC
AAGGAGCTCTGAATTGTGAGTCTGCCCCTCAGGGGAATTCGGAGCTAGAGGACATGGAAAATAAAGCCAGGAAAGTCAAAAAAACGAAAG
AGAAGGAGAAGAAAAAGGAAAAGGGCAAATTGAAAGTCAAGGAGAAAAAGCGCAAAGAGGAGAATGAAGATCCAGAAAGGAAAATAAAGA
AGAAGGGCTTCGGCGCCATGCTGAGGTATGGGCCTGCTTTGAAGGCAAAGTTGGTTCTCATTTTGTCTCTCCTGAAAAAAGCGCACGCTT
TTCCTCGTCTTCAGCCAAATGCATACGGCTCTCAATTCTGTGCTCGTTCTCTTTCTGCAGAGGCAGAGGAGCTTTTTGGGGAAAGTTACA

>9936_9936_10_BMPR2-PARD3B_BMPR2_chr2_203242273_ENST00000374580_PARD3B_chr2_206110501_ENST00000462231_length(amino acids)=253AA_BP=30
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVR
GRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BMPR2-PARD3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BMPR2-PARD3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BMPR2-PARD3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource