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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WRAP73-GRB14 (FusionGDB2 ID:99388)

Fusion Gene Summary for WRAP73-GRB14

check button Fusion gene summary
Fusion gene informationFusion gene name: WRAP73-GRB14
Fusion gene ID: 99388
HgeneTgene
Gene symbol

WRAP73

GRB14

Gene ID

49856

2888

Gene nameWD repeat containing, antisense to TP73growth factor receptor bound protein 14
SynonymsWDR8-
Cytomap

1p36.32

2q24.3

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein WRAP73WD repeat domain 8epididymis secretory sperm binding proteingrowth factor receptor-bound protein 14GRB14 adapter protein
Modification date2020031320200313
UniProtAcc.

Q14449

Ensembl transtripts involved in fusion geneENST00000270708, ENST00000378322, 
ENST00000497306, ENST00000263915, 
ENST00000543549, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 7 X 4=140
# samples 39
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/140*10)=-0.637429920615292
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WRAP73 [Title/Abstract] AND GRB14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWRAP73(3553558)-GRB14(165354000), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across WRAP73 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRB14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1407WRAP73chr1

3553558

-GRB14chr2

165354000

-


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Fusion Gene ORF analysis for WRAP73-GRB14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000270708ENST00000497306WRAP73chr1

3553558

-GRB14chr2

165354000

-
5CDS-intronENST00000378322ENST00000497306WRAP73chr1

3553558

-GRB14chr2

165354000

-
In-frameENST00000270708ENST00000263915WRAP73chr1

3553558

-GRB14chr2

165354000

-
In-frameENST00000270708ENST00000543549WRAP73chr1

3553558

-GRB14chr2

165354000

-
In-frameENST00000378322ENST00000263915WRAP73chr1

3553558

-GRB14chr2

165354000

-
In-frameENST00000378322ENST00000543549WRAP73chr1

3553558

-GRB14chr2

165354000

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000378322WRAP73chr13553558-ENST00000263915GRB14chr2165354000-1314575591093344
ENST00000378322WRAP73chr13553558-ENST00000543549GRB14chr2165354000-1307575591093344
ENST00000270708WRAP73chr13553558-ENST00000263915GRB14chr2165354000-132959081108366
ENST00000270708WRAP73chr13553558-ENST00000543549GRB14chr2165354000-132259081108366

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378322ENST00000263915WRAP73chr13553558-GRB14chr2165354000-0.0038477690.9961522
ENST00000378322ENST00000543549WRAP73chr13553558-GRB14chr2165354000-0.003857990.99614197
ENST00000270708ENST00000263915WRAP73chr13553558-GRB14chr2165354000-0.0044578670.9955421
ENST00000270708ENST00000543549WRAP73chr13553558-GRB14chr2165354000-0.0044962660.9955037

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Fusion Genomic Features for WRAP73-GRB14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WRAP73-GRB14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:3553558/chr2:165354000)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GRB14

Q14449

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWRAP73chr1:3553558chr2:165354000ENST00000270708-51246_86172461.0RepeatNote=WD 1
HgeneWRAP73chr1:3553558chr2:165354000ENST00000270708-51289_129172461.0RepeatNote=WD 2
TgeneGRB14chr1:3553558chr2:165354000ENST00000263915814439_535368541.0DomainSH2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWRAP73chr1:3553558chr2:165354000ENST00000270708-512176_210172461.0RepeatNote=WD 3
HgeneWRAP73chr1:3553558chr2:165354000ENST00000270708-512221_260172461.0RepeatNote=WD 4
HgeneWRAP73chr1:3553558chr2:165354000ENST00000270708-512328_369172461.0RepeatNote=WD 5
HgeneWRAP73chr1:3553558chr2:165354000ENST00000270708-512371_410172461.0RepeatNote=WD 6
TgeneGRB14chr1:3553558chr2:165354000ENST00000263915814106_192368541.0DomainRas-associating
TgeneGRB14chr1:3553558chr2:165354000ENST00000263915814234_342368541.0DomainPH


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Fusion Gene Sequence for WRAP73-GRB14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99388_99388_1_WRAP73-GRB14_WRAP73_chr1_3553558_ENST00000270708_GRB14_chr2_165354000_ENST00000263915_length(transcript)=1329nt_BP=590nt
GTTGCAGCCTGCTGCGCGCCCAGGGGTCCCGCGGGTTTTCGGGCGCAGGGTGGCGCCCGCGGCAGGCGGCGGCCATGAACTTCTCCGAGG
TATTCAAGCTCTCCAGCTTACTCTGCAAGTTCTCCCCGGACGGCAAGTACCTGGCTTCCTGTGTCCAGTACCGGTTAGTGGTCCGGGATG
TGAACACCCTTCAGATCCTTCAGCTGTACACGTGCCTAGACCAGATCCAGCACATCGAGTGGTCGGCAGACTCGCTCTTCATCCTGTGCG
CCATGTACAAGCGAGGGCTGGTGCAGGTCTGGTCTTTAGAGCAGCCCGAATGGCACTGCAAAATAGACGAGGGCTCAGCCGGGCTGGTGG
CCTCGTGCTGGAGCCCGGACGGGCGCCACATTCTCAACACCACGGAATTCCATCTGCGGATAACCGTCTGGTCCTTGTGCACAAAATCCG
TGTCTTACATCAAATACCCGAAAGCTTGTCTGCAGGGAATCACCTTCACCAGGGACGGCCGCTACATGGCGCTGGCAGAACGGCGCGACT
GCAAAGATTACGTGAGCATCTTCGTCTGCAGTGATTGGCAGCTCCTGCGGAGAAGTATATCAGAGAATTCCCTGGTAGCAATGGACTTCT
CAGGCCAGAAAAGCAGAGTTATAGAAAATCCCACTGAAGCCCTTTCAGTTGCGGTTGAAGAAGGACTCGCTTGGAGGAAAAAAGGATGTT
TACGCCTGGGCACTCACGGTAGCCCCACTGCCTCTTCACAGAGCTCTGCCACAAACATGGCTATCCACCGGTCCCAGCCATGGTTTCACC
ACAAAATTTCTAGAGATGAGGCTCAGCGATTGATTATTCAGCAAGGACTTGTGGATGGAGTTTTCTTGGTACGGGATAGTCAGAGTAACC
CCAAAACTTTCGTACTGTCAATGAGTCATGGACAAAAAATAAAGCACTTTCAAATTATACCAGTAGAAGATGACGGTGAAATGTTCCACA
CACTGGATGATGGCCACACAAGATTTACAGATCTAATACAGCTGGTGGAGTTCTATCAACTCAATAAGGGCGTTCTTCCTTGCAAGTTGA
AACATTATTGTGCTAGGATTGCTCTCTAGACAAGCCAGAAGTGACTTATTAAACTATTGAAGGAAAAGGACTCAAGAAAAATAATAAAAG
ACCATAAATAAGGGCGAAAACATTACCATGTGAAAAGAATGTATTTCACCTGCAAGTTACAAAAAAATAGTTTGTGCATTGCAAATAAGC

>99388_99388_1_WRAP73-GRB14_WRAP73_chr1_3553558_ENST00000270708_GRB14_chr2_165354000_ENST00000263915_length(amino acids)=366AA_BP=194
MLRAQGSRGFSGAGWRPRQAAAMNFSEVFKLSSLLCKFSPDGKYLASCVQYRLVVRDVNTLQILQLYTCLDQIQHIEWSADSLFILCAMY
KRGLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEFHLRITVWSLCTKSVSYIKYPKACLQGITFTRDGRYMALAERRDCKD
YVSIFVCSDWQLLRRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPTASSQSSATNMAIHRSQPWFHHKI
SRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHY

--------------------------------------------------------------
>99388_99388_2_WRAP73-GRB14_WRAP73_chr1_3553558_ENST00000270708_GRB14_chr2_165354000_ENST00000543549_length(transcript)=1322nt_BP=590nt
GTTGCAGCCTGCTGCGCGCCCAGGGGTCCCGCGGGTTTTCGGGCGCAGGGTGGCGCCCGCGGCAGGCGGCGGCCATGAACTTCTCCGAGG
TATTCAAGCTCTCCAGCTTACTCTGCAAGTTCTCCCCGGACGGCAAGTACCTGGCTTCCTGTGTCCAGTACCGGTTAGTGGTCCGGGATG
TGAACACCCTTCAGATCCTTCAGCTGTACACGTGCCTAGACCAGATCCAGCACATCGAGTGGTCGGCAGACTCGCTCTTCATCCTGTGCG
CCATGTACAAGCGAGGGCTGGTGCAGGTCTGGTCTTTAGAGCAGCCCGAATGGCACTGCAAAATAGACGAGGGCTCAGCCGGGCTGGTGG
CCTCGTGCTGGAGCCCGGACGGGCGCCACATTCTCAACACCACGGAATTCCATCTGCGGATAACCGTCTGGTCCTTGTGCACAAAATCCG
TGTCTTACATCAAATACCCGAAAGCTTGTCTGCAGGGAATCACCTTCACCAGGGACGGCCGCTACATGGCGCTGGCAGAACGGCGCGACT
GCAAAGATTACGTGAGCATCTTCGTCTGCAGTGATTGGCAGCTCCTGCGGAGAAGTATATCAGAGAATTCCCTGGTAGCAATGGACTTCT
CAGGCCAGAAAAGCAGAGTTATAGAAAATCCCACTGAAGCCCTTTCAGTTGCGGTTGAAGAAGGACTCGCTTGGAGGAAAAAAGGATGTT
TACGCCTGGGCACTCACGGTAGCCCCACTGCCTCTTCACAGAGCTCTGCCACAAACATGGCTATCCACCGGTCCCAGCCATGGTTTCACC
ACAAAATTTCTAGAGATGAGGCTCAGCGATTGATTATTCAGCAAGGACTTGTGGATGGAGTTTTCTTGGTACGGGATAGTCAGAGTAACC
CCAAAACTTTCGTACTGTCAATGAGTCATGGACAAAAAATAAAGCACTTTCAAATTATACCAGTAGAAGATGACGGTGAAATGTTCCACA
CACTGGATGATGGCCACACAAGATTTACAGATCTAATACAGCTGGTGGAGTTCTATCAACTCAATAAGGGCGTTCTTCCTTGCAAGTTGA
AACATTATTGTGCTAGGATTGCTCTCTAGACAAGCCAGAAGTGACTTATTAAACTATTGAAGGAAAAGGACTCAAGAAAAATAATAAAAG
ACCATAAATAAGGGCGAAAACATTACCATGTGAAAAGAATGTATTTCACCTGCAAGTTACAAAAAAATAGTTTGTGCATTGCAAATAAGC

>99388_99388_2_WRAP73-GRB14_WRAP73_chr1_3553558_ENST00000270708_GRB14_chr2_165354000_ENST00000543549_length(amino acids)=366AA_BP=194
MLRAQGSRGFSGAGWRPRQAAAMNFSEVFKLSSLLCKFSPDGKYLASCVQYRLVVRDVNTLQILQLYTCLDQIQHIEWSADSLFILCAMY
KRGLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEFHLRITVWSLCTKSVSYIKYPKACLQGITFTRDGRYMALAERRDCKD
YVSIFVCSDWQLLRRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPTASSQSSATNMAIHRSQPWFHHKI
SRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHY

--------------------------------------------------------------
>99388_99388_3_WRAP73-GRB14_WRAP73_chr1_3553558_ENST00000378322_GRB14_chr2_165354000_ENST00000263915_length(transcript)=1314nt_BP=575nt
GCGCCCAGGGGTCCCGCGGGTTTTCGGGCGCAGGGTGGCGCCCGCGGCAGGCGGCGGCCATGAACTTCTCCGAGGTATTCAAGCTCTCCA
GCTTACTCTGCAAGTTCTCCCCGGACGGCAAGTACCTGGCTTCCTGTGTCCAGTACCGGTTAGTGGTCCGGGATGTGAACACCCTTCAGA
TCCTTCAGCTGTACACGTGCCTAGACCAGATCCAGCACATCGAGTGGTCGGCAGACTCGCTCTTCATCCTGTGCGCCATGTACAAGCGAG
GGCTGGTGCAGGTCTGGTCTTTAGAGCAGCCCGAATGGCACTGCAAAATAGACGAGGGCTCAGCCGGGCTGGTGGCCTCGTGCTGGAGCC
CGGACGGGCGCCACATTCTCAACACCACGGAATTCCATCTGCGGATAACCGTCTGGTCCTTGTGCACAAAATCCGTGTCTTACATCAAAT
ACCCGAAAGCTTGTCTGCAGGGAATCACCTTCACCAGGGACGGCCGCTACATGGCGCTGGCAGAACGGCGCGACTGCAAAGATTACGTGA
GCATCTTCGTCTGCAGTGATTGGCAGCTCCTGCGGAGAAGTATATCAGAGAATTCCCTGGTAGCAATGGACTTCTCAGGCCAGAAAAGCA
GAGTTATAGAAAATCCCACTGAAGCCCTTTCAGTTGCGGTTGAAGAAGGACTCGCTTGGAGGAAAAAAGGATGTTTACGCCTGGGCACTC
ACGGTAGCCCCACTGCCTCTTCACAGAGCTCTGCCACAAACATGGCTATCCACCGGTCCCAGCCATGGTTTCACCACAAAATTTCTAGAG
ATGAGGCTCAGCGATTGATTATTCAGCAAGGACTTGTGGATGGAGTTTTCTTGGTACGGGATAGTCAGAGTAACCCCAAAACTTTCGTAC
TGTCAATGAGTCATGGACAAAAAATAAAGCACTTTCAAATTATACCAGTAGAAGATGACGGTGAAATGTTCCACACACTGGATGATGGCC
ACACAAGATTTACAGATCTAATACAGCTGGTGGAGTTCTATCAACTCAATAAGGGCGTTCTTCCTTGCAAGTTGAAACATTATTGTGCTA
GGATTGCTCTCTAGACAAGCCAGAAGTGACTTATTAAACTATTGAAGGAAAAGGACTCAAGAAAAATAATAAAAGACCATAAATAAGGGC
GAAAACATTACCATGTGAAAAGAATGTATTTCACCTGCAAGTTACAAAAAAATAGTTTGTGCATTGCAAATAAGCAAAGACTTGGATTGA

>99388_99388_3_WRAP73-GRB14_WRAP73_chr1_3553558_ENST00000378322_GRB14_chr2_165354000_ENST00000263915_length(amino acids)=344AA_BP=172
MNFSEVFKLSSLLCKFSPDGKYLASCVQYRLVVRDVNTLQILQLYTCLDQIQHIEWSADSLFILCAMYKRGLVQVWSLEQPEWHCKIDEG
SAGLVASCWSPDGRHILNTTEFHLRITVWSLCTKSVSYIKYPKACLQGITFTRDGRYMALAERRDCKDYVSIFVCSDWQLLRRSISENSL
VAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVR

--------------------------------------------------------------
>99388_99388_4_WRAP73-GRB14_WRAP73_chr1_3553558_ENST00000378322_GRB14_chr2_165354000_ENST00000543549_length(transcript)=1307nt_BP=575nt
GCGCCCAGGGGTCCCGCGGGTTTTCGGGCGCAGGGTGGCGCCCGCGGCAGGCGGCGGCCATGAACTTCTCCGAGGTATTCAAGCTCTCCA
GCTTACTCTGCAAGTTCTCCCCGGACGGCAAGTACCTGGCTTCCTGTGTCCAGTACCGGTTAGTGGTCCGGGATGTGAACACCCTTCAGA
TCCTTCAGCTGTACACGTGCCTAGACCAGATCCAGCACATCGAGTGGTCGGCAGACTCGCTCTTCATCCTGTGCGCCATGTACAAGCGAG
GGCTGGTGCAGGTCTGGTCTTTAGAGCAGCCCGAATGGCACTGCAAAATAGACGAGGGCTCAGCCGGGCTGGTGGCCTCGTGCTGGAGCC
CGGACGGGCGCCACATTCTCAACACCACGGAATTCCATCTGCGGATAACCGTCTGGTCCTTGTGCACAAAATCCGTGTCTTACATCAAAT
ACCCGAAAGCTTGTCTGCAGGGAATCACCTTCACCAGGGACGGCCGCTACATGGCGCTGGCAGAACGGCGCGACTGCAAAGATTACGTGA
GCATCTTCGTCTGCAGTGATTGGCAGCTCCTGCGGAGAAGTATATCAGAGAATTCCCTGGTAGCAATGGACTTCTCAGGCCAGAAAAGCA
GAGTTATAGAAAATCCCACTGAAGCCCTTTCAGTTGCGGTTGAAGAAGGACTCGCTTGGAGGAAAAAAGGATGTTTACGCCTGGGCACTC
ACGGTAGCCCCACTGCCTCTTCACAGAGCTCTGCCACAAACATGGCTATCCACCGGTCCCAGCCATGGTTTCACCACAAAATTTCTAGAG
ATGAGGCTCAGCGATTGATTATTCAGCAAGGACTTGTGGATGGAGTTTTCTTGGTACGGGATAGTCAGAGTAACCCCAAAACTTTCGTAC
TGTCAATGAGTCATGGACAAAAAATAAAGCACTTTCAAATTATACCAGTAGAAGATGACGGTGAAATGTTCCACACACTGGATGATGGCC
ACACAAGATTTACAGATCTAATACAGCTGGTGGAGTTCTATCAACTCAATAAGGGCGTTCTTCCTTGCAAGTTGAAACATTATTGTGCTA
GGATTGCTCTCTAGACAAGCCAGAAGTGACTTATTAAACTATTGAAGGAAAAGGACTCAAGAAAAATAATAAAAGACCATAAATAAGGGC
GAAAACATTACCATGTGAAAAGAATGTATTTCACCTGCAAGTTACAAAAAAATAGTTTGTGCATTGCAAATAAGCAAAGACTTGGATTGA

>99388_99388_4_WRAP73-GRB14_WRAP73_chr1_3553558_ENST00000378322_GRB14_chr2_165354000_ENST00000543549_length(amino acids)=344AA_BP=172
MNFSEVFKLSSLLCKFSPDGKYLASCVQYRLVVRDVNTLQILQLYTCLDQIQHIEWSADSLFILCAMYKRGLVQVWSLEQPEWHCKIDEG
SAGLVASCWSPDGRHILNTTEFHLRITVWSLCTKSVSYIKYPKACLQGITFTRDGRYMALAERRDCKDYVSIFVCSDWQLLRRSISENSL
VAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVR

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Fusion Gene PPI Analysis for WRAP73-GRB14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WRAP73-GRB14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WRAP73-GRB14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource