Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:WRB-BACE2 (FusionGDB2 ID:99392)

Fusion Gene Summary for WRB-BACE2

Fusion gene summary

Fusion gene information	Fusion gene name: WRB-BACE2
	Fusion gene ID: 99392
		Hgene	Tgene
	Gene symbol	WRB	BACE2
	Gene ID	7485	25825
	Gene name	guided entry of tail-anchored proteins factor 1	beta-secretase 2
	Synonyms	CHD5\|WRB	AEPLC\|ALP56\|ASP1\|ASP21\|BAE2\|CDA13\|CEAP1\|DRAP
	Cytomap	21q22.2	21q22.2-q22.3
	Type of gene	protein-coding	protein-coding
	Description	tail-anchored protein insertion receptor WRBcongenital heart disease 5 proteintryptophan rich basic protein	beta-secretase 256 kDa aspartic-like proteaseDown syndrome region aspartic proteaseSLCO3A1/BACE2 fusionaspartyl protease 1beta-site APP-cleaving enzyme 2beta-site amyloid beta A4 precursor protein-cleaving enzyme 2memapsin-1membrane-associated asp
	Modification date	20200313	20200313
	UniProtAcc	.	Q9Y5Z0
	Ensembl transtripts involved in fusion gene	ENST00000466787, ENST00000333781, ENST00000380708, ENST00000398753, ENST00000541890,	ENST00000328735, ENST00000330333, ENST00000347667, ENST00000466122,
Fusion gene scores	* DoF score	6 X 4 X 6=144	14 X 9 X 8=1008
	# samples	8	14
	** MAII score	log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1008*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: WRB [Title/Abstract] AND BACE2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	WRB(40763762)-BACE2(42647298), # samples:1
Anticipated loss of major functional domain due to fusion event.	WRB-BACE2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. WRB-BACE2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	BACE2	GO:0006509	membrane protein ectodomain proteolysis	10591213

Fusion gene breakpoints across WRB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BACE2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-G9-6353-01A	WRB	chr21	40763762	+	BACE2	chr21	42647298	+

Top

Fusion Gene ORF analysis for WRB-BACE2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000466787	ENST00000328735	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
3UTR-3CDS	ENST00000466787	ENST00000330333	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
3UTR-3CDS	ENST00000466787	ENST00000347667	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
3UTR-3UTR	ENST00000466787	ENST00000466122	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
5CDS-3UTR	ENST00000333781	ENST00000466122	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
5CDS-3UTR	ENST00000380708	ENST00000466122	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
5CDS-3UTR	ENST00000398753	ENST00000466122	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
5CDS-3UTR	ENST00000541890	ENST00000466122	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
Frame-shift	ENST00000333781	ENST00000330333	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
Frame-shift	ENST00000380708	ENST00000330333	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
Frame-shift	ENST00000398753	ENST00000330333	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
Frame-shift	ENST00000541890	ENST00000330333	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
In-frame	ENST00000333781	ENST00000328735	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
In-frame	ENST00000333781	ENST00000347667	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
In-frame	ENST00000380708	ENST00000328735	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
In-frame	ENST00000380708	ENST00000347667	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
In-frame	ENST00000398753	ENST00000328735	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
In-frame	ENST00000398753	ENST00000347667	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
In-frame	ENST00000541890	ENST00000328735	WRB	chr21	40763762	+	BACE2	chr21	42647298	+
In-frame	ENST00000541890	ENST00000347667	WRB	chr21	40763762	+	BACE2	chr21	42647298	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000333781	WRB	chr21	40763762	+	ENST00000328735	BACE2	chr21	42647298	+	1704	477	42	533	163
ENST00000333781	WRB	chr21	40763762	+	ENST00000347667	BACE2	chr21	42647298	+	7625	477	42	533	163
ENST00000541890	WRB	chr21	40763762	+	ENST00000328735	BACE2	chr21	42647298	+	1594	367	31	423	130
ENST00000541890	WRB	chr21	40763762	+	ENST00000347667	BACE2	chr21	42647298	+	7515	367	5241	5639	132
ENST00000398753	WRB	chr21	40763762	+	ENST00000328735	BACE2	chr21	42647298	+	1560	333	99	389	96
ENST00000398753	WRB	chr21	40763762	+	ENST00000347667	BACE2	chr21	42647298	+	7481	333	5207	5605	132
ENST00000380708	WRB	chr21	40763762	+	ENST00000328735	BACE2	chr21	42647298	+	1552	325	22	381	119
ENST00000380708	WRB	chr21	40763762	+	ENST00000347667	BACE2	chr21	42647298	+	7473	325	5199	5597	132

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000333781	ENST00000328735	WRB	chr21	40763762	+	BACE2	chr21	42647298	+	0.007438407	0.99256164
ENST00000333781	ENST00000347667	WRB	chr21	40763762	+	BACE2	chr21	42647298	+	0.020456072	0.979544
ENST00000541890	ENST00000328735	WRB	chr21	40763762	+	BACE2	chr21	42647298	+	0.009720334	0.99027973
ENST00000541890	ENST00000347667	WRB	chr21	40763762	+	BACE2	chr21	42647298	+	0.020141406	0.97985864
ENST00000398753	ENST00000328735	WRB	chr21	40763762	+	BACE2	chr21	42647298	+	0.030714843	0.9692852
ENST00000398753	ENST00000347667	WRB	chr21	40763762	+	BACE2	chr21	42647298	+	0.11893239	0.88106763
ENST00000380708	ENST00000328735	WRB	chr21	40763762	+	BACE2	chr21	42647298	+	0.017907001	0.982093
ENST00000380708	ENST00000347667	WRB	chr21	40763762	+	BACE2	chr21	42647298	+	0.12228572	0.8777142

Top

Fusion Genomic Features for WRB-BACE2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
WRB	chr21	40763762	+	BACE2	chr21	42647297	+	0.008920013	0.99108
WRB	chr21	40763762	+	BACE2	chr21	42647297	+	0.008920013	0.99108

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for WRB-BACE2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:40763762/chr21:42647298)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	BACE2 Q9Y5Z0
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). {ECO:0000269\|PubMed:10591213, ECO:0000269\|PubMed:11083922, ECO:0000269\|PubMed:11423558, ECO:0000269\|PubMed:15857888, ECO:0000269\|PubMed:16816112, ECO:0000269\|PubMed:21907142}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000333781

39_94

112

175.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000333781

1_8

112

175.0

Topological domain

Lumenal

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000333781

30_99

112

175.0

Topological domain

Cytoplasmic

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000380708

1_8

141.0

Topological domain

Lumenal

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000398753

1_8

141.0

Topological domain

Lumenal

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000333781

9_29

112

175.0

Transmembrane

Helical

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000380708

9_29

141.0

Transmembrane

Helical

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000398753

9_29

141.0

Transmembrane

Helical

Tgene

BACE2

chr21:40763762

chr21:42647298

ENST00000328735

495_518

378

397.0

Topological domain

Cytoplasmic

Tgene

BACE2

chr21:40763762

chr21:42647298

ENST00000330333

495_518

434

519.0

Topological domain

Cytoplasmic

Tgene

BACE2

chr21:40763762

chr21:42647298

ENST00000347667

495_518

384

469.0

Topological domain

Cytoplasmic

Tgene

BACE2

chr21:40763762

chr21:42647298

ENST00000328735

474_494

378

397.0

Transmembrane

Helical

Tgene

BACE2

chr21:40763762

chr21:42647298

ENST00000330333

474_494

434

519.0

Transmembrane

Helical

Tgene

BACE2

chr21:40763762

chr21:42647298

ENST00000347667

474_494

384

469.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000380708

39_94

141.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000398753

39_94

141.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000333781

121_148

112

175.0

Topological domain

Lumenal

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000333781

170_174

112

175.0

Topological domain

Cytoplasmic

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000380708

121_148

141.0

Topological domain

Lumenal

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000380708

170_174

141.0

Topological domain

Cytoplasmic

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000380708

30_99

141.0

Topological domain

Cytoplasmic

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000398753

121_148

141.0

Topological domain

Lumenal

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000398753

170_174

141.0

Topological domain

Cytoplasmic

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000398753

30_99

141.0

Topological domain

Cytoplasmic

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000333781

100_120

112

175.0

Transmembrane

Helical

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000333781

149_169

112

175.0

Transmembrane

Helical

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000380708

100_120

141.0

Transmembrane

Helical

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000380708

149_169

141.0

Transmembrane

Helical

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000398753

100_120

141.0

Transmembrane

Helical

Hgene

WRB

chr21:40763762

chr21:42647298

ENST00000398753

149_169

141.0

Transmembrane

Helical

Tgene

BACE2

chr21:40763762

chr21:42647298

ENST00000328735

92_429

378

397.0

Domain

Peptidase A1

Tgene

BACE2

chr21:40763762

chr21:42647298

ENST00000330333

92_429

434

519.0

Domain

Peptidase A1

Tgene

BACE2

chr21:40763762

chr21:42647298

ENST00000347667

92_429

384

469.0

Domain

Peptidase A1

Tgene

BACE2

chr21:40763762

chr21:42647298

ENST00000328735

21_473

378

397.0

Topological domain

Extracellular

Tgene

BACE2

chr21:40763762

chr21:42647298

ENST00000330333

21_473

434

519.0

Topological domain

Extracellular

Tgene

BACE2

chr21:40763762

chr21:42647298

ENST00000347667

21_473

384

469.0

Topological domain

Extracellular

Top

Fusion Gene Sequence for WRB-BACE2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>99392_99392_1_WRB-BACE2_WRB_chr21_40763762_ENST00000333781_BACE2_chr21_42647298_ENST00000328735_length(transcript)=1704nt_BP=477nt
CGCGAGGGCGACGCAGTTCGCAGGCGCGTCGGCGCGCCTGTTCTGGGGCGCTTGGCTTCACCGCGCAGGCGCGGTCGCCGCTGTTGTTGT
GGTCCCCATGGAGCTGCCGTAGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTG
GTGCTCAGCTTCGTGTTTGGATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCATGTCCAGGGTGCTGCAGAAGGACGCG
GAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAACATGATGGACGAGTTTGCCAGATATGCC
AGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTG
ATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCA
ACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCT
TAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCAATGATGAGTCCTCTCTGGTCAGACATC
GCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCACATTTCCAGGGCAGCAGCCGGGATCGAT
GGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTAGATTCACTGTCTTTTGATTCTTGATTTT
CAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAACCAAAACAGAGTGGATTGGGCTGCAGGCT
CTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTC
TGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAATTGCCTTTGAGGTTATTTTCCGCCAGAC
CTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGGGGCCTGGGGATGTAACCAAGCTGTACCC
TTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAGCCAGAATTCACTAGGAGGTCATCAACCG
ATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAGGAAATCTCCTCTTTTGTACCCAATACTT
ATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTT
GACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTGCTGAACTGTGCATCAACCAGGAAGAGTT

>99392_99392_1_WRB-BACE2_WRB_chr21_40763762_ENST00000333781_BACE2_chr21_42647298_ENST00000328735_length(amino acids)=163AA_BP=144
MGRLASPRRRGRRCCCGPHGAAVADPAQPGASGMSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMK

--------------------------------------------------------------
>99392_99392_2_WRB-BACE2_WRB_chr21_40763762_ENST00000333781_BACE2_chr21_42647298_ENST00000347667_length(transcript)=7625nt_BP=477nt
CGCGAGGGCGACGCAGTTCGCAGGCGCGTCGGCGCGCCTGTTCTGGGGCGCTTGGCTTCACCGCGCAGGCGCGGTCGCCGCTGTTGTTGT
GGTCCCCATGGAGCTGCCGTAGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTG
GTGCTCAGCTTCGTGTTTGGATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCATGTCCAGGGTGCTGCAGAAGGACGCG
GAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAACATGATGGACGAGTTTGCCAGATATGCC
AGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTG
ATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCA
ACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCT
TAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCAATGATGAGTCCTCTCTGGTCAGACATC
GCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCACATTTCCAGGGCAGCAGCCGGGATCGAT
GGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTAGATTCACTGTCTTTTGATTCTTGATTTT
CAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAACCAAAACAGAGTGGATTGGGCTGCAGGCT
CTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTC
TGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAATTGCCTTTGAGGTTATTTTCCGCCAGAC
CTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGGGGCCTGGGGATGTAACCAAGCTGTACCC
TTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAGCCAGAATTCACTAGGAGGTCATCAACCG
ATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAGGAAATCTCCTCTTTTGTACCCAATACTT
ATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTT
GACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTGCTGAACTGTGCATCAACCAGGAAGAGTT
CTATCCCCAAGCTGGCCACTATCACATATGCTTACTCTTGCTTAAAATTAATAAATCATGTTTTGATGAGAAAAAACTATTCTATTTCAC
TAGCTTAGTTGTCTCTTTTTCCAAATCTTCTCTGGAAGTAGGTTGGCTATTACCCTGTTGGGAAACAGGGAAATGGCCTGATGCCCCTAT
TTCTGACCAGCTGTCAGGGAAGGAAGATGCAAGATGTGCAGAAGACACAAGGTAACGTCTACTTATCCCCGTGCTTCGAAACCGTGTGTT
TCCCTTTGCAGAACTGGTTAGCCTCAAGCATACCCATCCAATCAGCTTAAATTGTTCAGCAGTTGACCTCTGTGCTTCTTCCTTTGGGGG
TGTTTAATCTTTGGTAACAGTTGTGCAGTGGTAGCCTTATTTCGGGGGGCAGTCCCTACTTTCTGTCACTTATCGAGGCCTTTGCCAAAG
AAAAGTGGAAGCCGTTTCCTTGACATAGCCTTATATGACCTGATGTCATTAGGAGAAGAGTTAAAAGACAGTATCCCCTCTCTCCTGCTT
GTGTGCCAAGTTCAGTGTTCCCTTTGCATTTTTTTGGGGTGGGTTGGCTATATTACAGAATTCCACCAAAAGTGCTAAGTGTCCCCTCCT
GCAGAAGTATCGTTTGTATTCACAGTAGGCTACGTGTGGATGTTTCAGCCATCTGCTCTGCTCCCTGGGTCCCCGGGTCACCACCATACT
GAGAAATATAGGACTCTGCCAAAGAGACGTGGAGGCCACGTCGGCTTGTCATGGTGTCCTGGAAGACTCTCCAGCAGCCAGAAGAACCTT
CTGTGCTGTTTTCACTAGAGAAGATTTGAGTTGCAGCCTCTTGGAAAGAACATGACGGCACGGAACGGGAGGAGGGGGCTCTTGTATCAG
GGCCCGTTGTCACATCCGCTCTCAGCTTGTTGAAAACTCATAATCTCAGAATGCATTTCACACGGAGAGATGTCTGGAAGTCCAATTCTC
ATCCCATTGGCTTTTTCCGTGGTTGCTGTTTTGTGGGCCGCTTTGCACAGGAGTGAAGCCAACACCCCTAGATTGTGCCTTCACCCTTGC
TGTGAAAAATTCAAAGCCCTGAAATAAGAGGAGGGAATCGCAGACATGCCCTGATTAGTTTTCCTGCTTATTTCTTCATACAGGCATCTT
CTGTTCCGTTGTATTGTGTTAGGTTTCAGAGGCGGGGAGCTTCCTCCTGCAGCAGATGAACAGGCATAGTTCTTAAAATACAGGAAAGTA
ACAAGTGAGGTTTCCAGGTAGAGTAGGTGAATGAAGTTTGCCGTCATGCTCTGTATTTCATATCAGATTTCTTTATCTTTTCATATCGCA
TGTCATTGGATGTGACATTTTGATGAAAATACTGAAACTACAAAAGCATAACTTCGCAACAAGAATGAGATAGACAATTGAATGTGGGAC
ATTTTTCTGGCATGTCTTGCTGCTGAGAATCGGACTTCCAGTCAAAACCCTGTTAGTGACACCCACCTCCTCCAGTTATGCAAATTGATG
CTTAGCTTGGCAAGCTTTCAAGGAGGTTTGCTTGGAACAGGAAAGGAATTAACAACCCTTTGAGGGTGTCATTTTTACCTTGTAATACAC
TGTGGAAAATTCTGGAAGACGGTCCTTGCCTGAAAAGGTGCAACTTAGCATTAGGTTGTTATCAGAAACCTTGTCAAGTCTGATGGGAAA
TGAATAGATGCTGCTTTATTTCCTTGATAACTTCTTTGGAAGTCTGAAATAAATCCTGCCTTCAGTAACTGAAACCATTTATTAAAAATA
GCAAGAAACAAGATGGGGACCAATTCTATTTTTATTCTTGGGAATTTGAAAGAGCCACAAGTGATTGGTGTCCGATCTCCCAGCATATAC
TGTACACTATTTTGTATTTCTCCTGAACCAAAACCAAGTACTTAGCACTCAAGAAACAGATGCCCTGTGTGTGACCGAGGGGAGTGTTTT
TCCACAACAGGTTCCACTTCTGAACACTTGGAAGGACCTTGCCTGATTCATGGTGAAACACAGAGGTTTTGGTTGGAGATAAATTTGGGG
TCAGTTACTGTTCAAAATTGTGAAAGTAGTTCCCAGGAAGACAGCATTAGTGACTCCGCAGTGCTTTGGGTAATAGATTTTGAAAAGCAA
TTGTGAGTTGGGGATTCCATCATTTCATTTAAGAGGTGAAGAGGGATTTAATTATTTAATACGCCGGGTGCAAACTTGTTAAATTCCTCT
TTCCCTGTCCCTGCTTGGTGGAGCTGCCACGTGTGGTTCAGTTCTAAGTTCTGGACTAGTGCCACTCGATATCATTGGGAATAAATCGTT
GTTCAACAGTCTGTTCCACAAACAACAGTAATTGAATTTCACAGACTTTATCCTGATTAGTGGAAATCAAATAATGGAGTGGAATCCCCA
TGTGTTTTCTCTTGCACAAACTTATTAGACTTGATTAGAAAACTGTTTGGAGGAAAAACTTGCCAGTAAGTTTTTTGGTTGTTGTTTTGT
TTTTTTTGAAAAACGACGCAACACCATAAAGTGTAAAATTAGGGGTTCTGGCCAAGAGAGGTACTAGATTTTTTTAATGCCGAGAAAAGT
CCATGCCACAGAAGTTATTGTGTATGTCTCTAGGGAGCTTTAAGAATTTCACGTTTGAACTTTACAGCTGTTTACCAATTAAATGGCAAG
CTGGAAAAATACATTTTGAGAGGGGTAGAAAGAATAAGAATATAATTAAAAGTATGCTAACAAAATAAGCAGTACATATTTTTTTAGAAA
ATGCAGTTTAGGCCAGGCACGGTAGCTCGTGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTT
GAGACCAGCCTGGACAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAACGATGGTGATGCCTGTCTGTAATCCCAG
CTACTCTGGAGGCTGAGGCAGGAGAATCGCTTGAACCGGGGAGGCAGAGGTTGTAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGG
GCAACAGAGCAAGACTCCGTCTCAAAAAAGGAAAGAAAATGCAGTTTCATTCCAGCCATCCTTAGATTTCTTTTCCCCTTAAAGTGGCTG
AATCCATTGGAGATGTGATTTATTTTGCAGATCCACCAATTCCAAACTTCAGGAATATTCAAGCGGGAGTCATGTGTAAGTGACAGCTTT
GACAAAGAGAGACTGTGGCTGGGTGGCCCGGGTGTTGCCCACGCGGAGCAAGGATTGGTTCATTCAACGGATGGAGAGTACAGGATGGCT
GGGACCTGGGAAGTTCCAGAATCTGAAAAGAGGGCAGGGCAAGAAGGAGCCAGAAGAGAGGTCCCACCCCTCAGTTGGCAGTGGGGCACG
GAGGTCCGCATCAGCCAAGAACGTCCCCAGGATGCCGTGGGCACCTCATTTCACCCCACGTTTTTGGCACAGTCTACTTTTTAGGTATTT
TGTAAAGGAACTTCTCAGGATTGATTATTTGCCAGAGGAACAATTAGGCCAAGAGAAACTTGCTTGACAGCCATGTGTAAAACACGTCTG
TCCTAATCAAACTAGAGATGCCTCAAGGCCCACGCAGGACACAGGCAGGTTCAAGGTCATGCACCTGGAAATTTGTAGGGGAGGGTCAAG
CAACTGAGGCCAAAGGGGGCCGGTAAAGTGGCTTCTGGGGTCTGAGCATCTGGAAGGCTCCTGGCAGCAGTTACCTGACAGTGTCGTTGA
GGGGCACGGCAGCTGGGCCCTCACCGTTTCCGCCAGCTCTGCTGAGCCAGCCCAGCCCATGCATTCCGAACATCCGACAGCTTCTTTCTC
CAGAATGTCTTCTGTCAGAGACTTCCAGGAAAGGAGCTCCCTCCTGTCTCACTGCTGTCAGCGTGGGAGCCCTGCTCCCCAGGCTCCACG
TCCCCGGAAGGTCCATCTTGTCCTGGAGCACACCCAGCCCCATTCAGGGTCAGTGCAGGAGGGAACAGGGAATCTGCATTTCAGTAAGCT
CCCCAGGTGAGGCTGCAGAGCAGAAACCACGGCTTTCAGACGTGAGCAGGCTCCCTGGGCTCTTGGTGTCACCCTGTTAGCCACATCTGC
GGAATGTGGAAGGCAGAACATAGCCACGCTGCTTAGTGCTGCCAGCGAACCTCAGGTTGCATCAGTGGCTGGAATCTATCACAGCTGTTG
GGGATACGTAACTCCCAGCAATAAATCCAGTATTTTCTTCCCTGCCCTGAGCTTCCTCTGGGTTTCTTATCAGCAGCTATTACACACAGA
TGTCCAGTGCTTCTAAACTAAATTGTACTGTGTAACTTTTACATCACACTTGTGTGCTTAAAAAGCACACCGTGGGTAGTGACTGGGCCA
AGAGACATCACAAAGCTTCCTGATAAATTTGAATCCAGCCACGGCAAGAGCGACGTGCGGGTACCTGGTCCCTGATGCTTGGGTGCCCCG
TTGAGCCTCGGGTACTTCTTGGACACTATTGTGAGAGCAGCCATCCTGGTGTCTCTGCCAGCATCTTGGGGAACGCTGTGATGGTAAAAT
ATCTGTCTCTCCTCTGGGAATCAGGGCAGCCCTGAGAAGTGAGCAGTTCCCTTTACAGATGGATAATTGTTTGTGTAAGACCAACCAGAT
AAAGTCCAAACTGTGTAGAACACACGTGTGCCTCACACATAGCCATCTGAGTAAAATATTTTTTCCAATGTAGATTTATAATTAGAAATG
ACAGATTTATAATATAGACTTCAGTAAGTTGGGCACAGCTGTCACTTTCGTGGTATCAATAAAAGGCTAGAAACCTTGGGTGTCCTTGGC
AACCTAGCCTTTGACATTGATGTTTTTCCATAGGATTTTCTTCATTTGGGTTGGAATAAAAATGCATTTTTATTCACAAGGCACAGACAG
ATAAGAATATCATAAGCAGGGAAGTGTCTCCAAAGGTCAGGACATATGTTTTTCTGTTGAGTGCTATATGTGGAGGTCATTGCAAGTTCC
CTGATATGAGTATGGTTTCGCTTGCTACATTGTGCCTATTAAAGTAAAATTTTACACAAGCCTCGCATTTCTAAGATTAGTGTTCCTGAA
TGAAATGTTAAGAAAACATTAAAAGATTATCTCTTTTTAAGATGGAGGAAAAAAAGTGAACAAAGCTAATTAATCTATCATGAAAATTGC
ACAAAATAACATTTCTTAACAAATTTAATACAATTTTGTGTTCTTTGTTGCTAGTGGTATAAAACGAGATTTTTTTCCCTCATTTTTCTC
ATTGTAGATGTCATCTCTCACATTTATATCAGTGAGGTTTGAAATTCTGTGTAGCAGTTACTCAGCACATATGAGAGGGCAGCGAATGAA
TGAGATTTGTCATGTGCTAATAAAAGCTGAATTTTTGTAATCTAAAATGATGTATTTTCTACTATTGCTGTTAATTTGCATTGTTAAAAA
TTCTTAAAGTTTAATATGTTATGTTCAGTCATTGAAAGCGACCACTCATTTTTTTCTTAAAGTTGATGCCTTTTCTGCTGTGCTAGAGTC
AGTATTTTGCTTCTGGCAGGAGAGCTGCAAACTGTGTATCCTCAAACAGATGCAAAAAGTAGTGCTTTGCAAAACGTTTGTTTTCTGTTT
ATCTCAGATTAACATCCTTTAATACAAGTTTCTTAAGTGTAACTTGTATTTCTGAAAATGCTTAAAATTATTTTATATTTCCCTTTGGGA
ATTTTTCTCTATTTCCAGCACGCTGATTTGATTTAAAAATGTAATAAGACCAAGAGTTGGAGTAAAGGGATATTCATTCCATGTTAAAAG
TGGCTTCATAGCTACTGACAAATGTCTGAACTATTGTCGTGCCCTTCAAAACTGGAGTTTTCTAAAATAATCTTATTTTTATACTTGTAT

>99392_99392_2_WRB-BACE2_WRB_chr21_40763762_ENST00000333781_BACE2_chr21_42647298_ENST00000347667_length(amino acids)=163AA_BP=144
MGRLASPRRRGRRCCCGPHGAAVADPAQPGASGMSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMK

--------------------------------------------------------------
>99392_99392_3_WRB-BACE2_WRB_chr21_40763762_ENST00000380708_BACE2_chr21_42647298_ENST00000328735_length(transcript)=1552nt_BP=325nt
ATGCGCAGACACCCTCAGGCGACTGGCGGGTCGCGGCTTCCAAGCTCTAAATGGAGAGTTGTCCCTACTGTGCGGCAGGCGGAGGAGACC
TATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAA
CATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGAC
AGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGG
CCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATG
AGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTC
AATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCA
CATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTA
GATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAAC
CAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCT
TGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAA
TTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGG
GGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAG
CCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAG
GAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCT
GTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTG
CTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACTATCACATATGCTTACTCTTGCTTAAAATTAATAAATCATGTT

>99392_99392_3_WRB-BACE2_WRB_chr21_40763762_ENST00000380708_BACE2_chr21_42647298_ENST00000328735_length(amino acids)=119AA_BP=100
MAGRGFQALNGELSLLCGRRRRPMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIK

--------------------------------------------------------------
>99392_99392_4_WRB-BACE2_WRB_chr21_40763762_ENST00000380708_BACE2_chr21_42647298_ENST00000347667_length(transcript)=7473nt_BP=325nt
ATGCGCAGACACCCTCAGGCGACTGGCGGGTCGCGGCTTCCAAGCTCTAAATGGAGAGTTGTCCCTACTGTGCGGCAGGCGGAGGAGACC
TATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAA
CATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGAC
AGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGG
CCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATG
AGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTC
AATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCA
CATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTA
GATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAAC
CAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCT
TGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAA
TTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGG
GGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAG
CCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAG
GAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCT
GTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTG
CTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACTATCACATATGCTTACTCTTGCTTAAAATTAATAAATCATGTT
TTGATGAGAAAAAACTATTCTATTTCACTAGCTTAGTTGTCTCTTTTTCCAAATCTTCTCTGGAAGTAGGTTGGCTATTACCCTGTTGGG
AAACAGGGAAATGGCCTGATGCCCCTATTTCTGACCAGCTGTCAGGGAAGGAAGATGCAAGATGTGCAGAAGACACAAGGTAACGTCTAC
TTATCCCCGTGCTTCGAAACCGTGTGTTTCCCTTTGCAGAACTGGTTAGCCTCAAGCATACCCATCCAATCAGCTTAAATTGTTCAGCAG
TTGACCTCTGTGCTTCTTCCTTTGGGGGTGTTTAATCTTTGGTAACAGTTGTGCAGTGGTAGCCTTATTTCGGGGGGCAGTCCCTACTTT
CTGTCACTTATCGAGGCCTTTGCCAAAGAAAAGTGGAAGCCGTTTCCTTGACATAGCCTTATATGACCTGATGTCATTAGGAGAAGAGTT
AAAAGACAGTATCCCCTCTCTCCTGCTTGTGTGCCAAGTTCAGTGTTCCCTTTGCATTTTTTTGGGGTGGGTTGGCTATATTACAGAATT
CCACCAAAAGTGCTAAGTGTCCCCTCCTGCAGAAGTATCGTTTGTATTCACAGTAGGCTACGTGTGGATGTTTCAGCCATCTGCTCTGCT
CCCTGGGTCCCCGGGTCACCACCATACTGAGAAATATAGGACTCTGCCAAAGAGACGTGGAGGCCACGTCGGCTTGTCATGGTGTCCTGG
AAGACTCTCCAGCAGCCAGAAGAACCTTCTGTGCTGTTTTCACTAGAGAAGATTTGAGTTGCAGCCTCTTGGAAAGAACATGACGGCACG
GAACGGGAGGAGGGGGCTCTTGTATCAGGGCCCGTTGTCACATCCGCTCTCAGCTTGTTGAAAACTCATAATCTCAGAATGCATTTCACA
CGGAGAGATGTCTGGAAGTCCAATTCTCATCCCATTGGCTTTTTCCGTGGTTGCTGTTTTGTGGGCCGCTTTGCACAGGAGTGAAGCCAA
CACCCCTAGATTGTGCCTTCACCCTTGCTGTGAAAAATTCAAAGCCCTGAAATAAGAGGAGGGAATCGCAGACATGCCCTGATTAGTTTT
CCTGCTTATTTCTTCATACAGGCATCTTCTGTTCCGTTGTATTGTGTTAGGTTTCAGAGGCGGGGAGCTTCCTCCTGCAGCAGATGAACA
GGCATAGTTCTTAAAATACAGGAAAGTAACAAGTGAGGTTTCCAGGTAGAGTAGGTGAATGAAGTTTGCCGTCATGCTCTGTATTTCATA
TCAGATTTCTTTATCTTTTCATATCGCATGTCATTGGATGTGACATTTTGATGAAAATACTGAAACTACAAAAGCATAACTTCGCAACAA
GAATGAGATAGACAATTGAATGTGGGACATTTTTCTGGCATGTCTTGCTGCTGAGAATCGGACTTCCAGTCAAAACCCTGTTAGTGACAC
CCACCTCCTCCAGTTATGCAAATTGATGCTTAGCTTGGCAAGCTTTCAAGGAGGTTTGCTTGGAACAGGAAAGGAATTAACAACCCTTTG
AGGGTGTCATTTTTACCTTGTAATACACTGTGGAAAATTCTGGAAGACGGTCCTTGCCTGAAAAGGTGCAACTTAGCATTAGGTTGTTAT
CAGAAACCTTGTCAAGTCTGATGGGAAATGAATAGATGCTGCTTTATTTCCTTGATAACTTCTTTGGAAGTCTGAAATAAATCCTGCCTT
CAGTAACTGAAACCATTTATTAAAAATAGCAAGAAACAAGATGGGGACCAATTCTATTTTTATTCTTGGGAATTTGAAAGAGCCACAAGT
GATTGGTGTCCGATCTCCCAGCATATACTGTACACTATTTTGTATTTCTCCTGAACCAAAACCAAGTACTTAGCACTCAAGAAACAGATG
CCCTGTGTGTGACCGAGGGGAGTGTTTTTCCACAACAGGTTCCACTTCTGAACACTTGGAAGGACCTTGCCTGATTCATGGTGAAACACA
GAGGTTTTGGTTGGAGATAAATTTGGGGTCAGTTACTGTTCAAAATTGTGAAAGTAGTTCCCAGGAAGACAGCATTAGTGACTCCGCAGT
GCTTTGGGTAATAGATTTTGAAAAGCAATTGTGAGTTGGGGATTCCATCATTTCATTTAAGAGGTGAAGAGGGATTTAATTATTTAATAC
GCCGGGTGCAAACTTGTTAAATTCCTCTTTCCCTGTCCCTGCTTGGTGGAGCTGCCACGTGTGGTTCAGTTCTAAGTTCTGGACTAGTGC
CACTCGATATCATTGGGAATAAATCGTTGTTCAACAGTCTGTTCCACAAACAACAGTAATTGAATTTCACAGACTTTATCCTGATTAGTG
GAAATCAAATAATGGAGTGGAATCCCCATGTGTTTTCTCTTGCACAAACTTATTAGACTTGATTAGAAAACTGTTTGGAGGAAAAACTTG
CCAGTAAGTTTTTTGGTTGTTGTTTTGTTTTTTTTGAAAAACGACGCAACACCATAAAGTGTAAAATTAGGGGTTCTGGCCAAGAGAGGT
ACTAGATTTTTTTAATGCCGAGAAAAGTCCATGCCACAGAAGTTATTGTGTATGTCTCTAGGGAGCTTTAAGAATTTCACGTTTGAACTT
TACAGCTGTTTACCAATTAAATGGCAAGCTGGAAAAATACATTTTGAGAGGGGTAGAAAGAATAAGAATATAATTAAAAGTATGCTAACA
AAATAAGCAGTACATATTTTTTTAGAAAATGCAGTTTAGGCCAGGCACGGTAGCTCGTGCCTGTAATCCCAGCACTTTGGGAGGCCGAGG
CAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGACAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAA
CGATGGTGATGCCTGTCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCGCTTGAACCGGGGAGGCAGAGGTTGTAGTGAGCC
AAGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCGTCTCAAAAAAGGAAAGAAAATGCAGTTTCATTCCAGCCATCCT
TAGATTTCTTTTCCCCTTAAAGTGGCTGAATCCATTGGAGATGTGATTTATTTTGCAGATCCACCAATTCCAAACTTCAGGAATATTCAA
GCGGGAGTCATGTGTAAGTGACAGCTTTGACAAAGAGAGACTGTGGCTGGGTGGCCCGGGTGTTGCCCACGCGGAGCAAGGATTGGTTCA
TTCAACGGATGGAGAGTACAGGATGGCTGGGACCTGGGAAGTTCCAGAATCTGAAAAGAGGGCAGGGCAAGAAGGAGCCAGAAGAGAGGT
CCCACCCCTCAGTTGGCAGTGGGGCACGGAGGTCCGCATCAGCCAAGAACGTCCCCAGGATGCCGTGGGCACCTCATTTCACCCCACGTT
TTTGGCACAGTCTACTTTTTAGGTATTTTGTAAAGGAACTTCTCAGGATTGATTATTTGCCAGAGGAACAATTAGGCCAAGAGAAACTTG
CTTGACAGCCATGTGTAAAACACGTCTGTCCTAATCAAACTAGAGATGCCTCAAGGCCCACGCAGGACACAGGCAGGTTCAAGGTCATGC
ACCTGGAAATTTGTAGGGGAGGGTCAAGCAACTGAGGCCAAAGGGGGCCGGTAAAGTGGCTTCTGGGGTCTGAGCATCTGGAAGGCTCCT
GGCAGCAGTTACCTGACAGTGTCGTTGAGGGGCACGGCAGCTGGGCCCTCACCGTTTCCGCCAGCTCTGCTGAGCCAGCCCAGCCCATGC
ATTCCGAACATCCGACAGCTTCTTTCTCCAGAATGTCTTCTGTCAGAGACTTCCAGGAAAGGAGCTCCCTCCTGTCTCACTGCTGTCAGC
GTGGGAGCCCTGCTCCCCAGGCTCCACGTCCCCGGAAGGTCCATCTTGTCCTGGAGCACACCCAGCCCCATTCAGGGTCAGTGCAGGAGG
GAACAGGGAATCTGCATTTCAGTAAGCTCCCCAGGTGAGGCTGCAGAGCAGAAACCACGGCTTTCAGACGTGAGCAGGCTCCCTGGGCTC
TTGGTGTCACCCTGTTAGCCACATCTGCGGAATGTGGAAGGCAGAACATAGCCACGCTGCTTAGTGCTGCCAGCGAACCTCAGGTTGCAT
CAGTGGCTGGAATCTATCACAGCTGTTGGGGATACGTAACTCCCAGCAATAAATCCAGTATTTTCTTCCCTGCCCTGAGCTTCCTCTGGG
TTTCTTATCAGCAGCTATTACACACAGATGTCCAGTGCTTCTAAACTAAATTGTACTGTGTAACTTTTACATCACACTTGTGTGCTTAAA
AAGCACACCGTGGGTAGTGACTGGGCCAAGAGACATCACAAAGCTTCCTGATAAATTTGAATCCAGCCACGGCAAGAGCGACGTGCGGGT
ACCTGGTCCCTGATGCTTGGGTGCCCCGTTGAGCCTCGGGTACTTCTTGGACACTATTGTGAGAGCAGCCATCCTGGTGTCTCTGCCAGC
ATCTTGGGGAACGCTGTGATGGTAAAATATCTGTCTCTCCTCTGGGAATCAGGGCAGCCCTGAGAAGTGAGCAGTTCCCTTTACAGATGG
ATAATTGTTTGTGTAAGACCAACCAGATAAAGTCCAAACTGTGTAGAACACACGTGTGCCTCACACATAGCCATCTGAGTAAAATATTTT
TTCCAATGTAGATTTATAATTAGAAATGACAGATTTATAATATAGACTTCAGTAAGTTGGGCACAGCTGTCACTTTCGTGGTATCAATAA
AAGGCTAGAAACCTTGGGTGTCCTTGGCAACCTAGCCTTTGACATTGATGTTTTTCCATAGGATTTTCTTCATTTGGGTTGGAATAAAAA
TGCATTTTTATTCACAAGGCACAGACAGATAAGAATATCATAAGCAGGGAAGTGTCTCCAAAGGTCAGGACATATGTTTTTCTGTTGAGT
GCTATATGTGGAGGTCATTGCAAGTTCCCTGATATGAGTATGGTTTCGCTTGCTACATTGTGCCTATTAAAGTAAAATTTTACACAAGCC
TCGCATTTCTAAGATTAGTGTTCCTGAATGAAATGTTAAGAAAACATTAAAAGATTATCTCTTTTTAAGATGGAGGAAAAAAAGTGAACA
AAGCTAATTAATCTATCATGAAAATTGCACAAAATAACATTTCTTAACAAATTTAATACAATTTTGTGTTCTTTGTTGCTAGTGGTATAA
AACGAGATTTTTTTCCCTCATTTTTCTCATTGTAGATGTCATCTCTCACATTTATATCAGTGAGGTTTGAAATTCTGTGTAGCAGTTACT
CAGCACATATGAGAGGGCAGCGAATGAATGAGATTTGTCATGTGCTAATAAAAGCTGAATTTTTGTAATCTAAAATGATGTATTTTCTAC
TATTGCTGTTAATTTGCATTGTTAAAAATTCTTAAAGTTTAATATGTTATGTTCAGTCATTGAAAGCGACCACTCATTTTTTTCTTAAAG
TTGATGCCTTTTCTGCTGTGCTAGAGTCAGTATTTTGCTTCTGGCAGGAGAGCTGCAAACTGTGTATCCTCAAACAGATGCAAAAAGTAG
TGCTTTGCAAAACGTTTGTTTTCTGTTTATCTCAGATTAACATCCTTTAATACAAGTTTCTTAAGTGTAACTTGTATTTCTGAAAATGCT
TAAAATTATTTTATATTTCCCTTTGGGAATTTTTCTCTATTTCCAGCACGCTGATTTGATTTAAAAATGTAATAAGACCAAGAGTTGGAG
TAAAGGGATATTCATTCCATGTTAAAAGTGGCTTCATAGCTACTGACAAATGTCTGAACTATTGTCGTGCCCTTCAAAACTGGAGTTTTC
TAAAATAATCTTATTTTTATACTTGTATGTTCCAGCAATTTAAGATATATACCATTGAAAGGGAAATAAAACATTTTTGTTTATTTGAAT

>99392_99392_4_WRB-BACE2_WRB_chr21_40763762_ENST00000380708_BACE2_chr21_42647298_ENST00000347667_length(amino acids)=132AA_BP=
MSIWKAPGSSYLTVSLRGTAAGPSPFPPALLSQPSPCIPNIRQLLSPECLLSETSRKGAPSCLTAVSVGALLPRLHVPGRSILSWSTPSP

--------------------------------------------------------------
>99392_99392_5_WRB-BACE2_WRB_chr21_40763762_ENST00000398753_BACE2_chr21_42647298_ENST00000328735_length(transcript)=1560nt_BP=333nt
GGATCCTCCTCCCGTCCTTCTCATCCTTCGTAAGTGGCTGCCTGGCCTCCCAAGGGCCGGTGGGGATGCCGCCCCAGTCCCCCGGCGGGT
CTGGCGTAGATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCC
ACAGTCAACATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAA
GCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAA
TTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATG
CGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTG
AGGTCGTCAATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAA
GAAAATCACATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGAT
GCCTTCTAGATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCA
TTCTAAACCAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAA
CCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTT
TGTATTAATTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAAT
CAGCCTGGGGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTG
AATGGGAGCCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAG
AGGGGAAGGAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCC
AGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCC
AACAGGTGCTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACTATCACATATGCTTACTCTTGCTTAAAATTAATAA

>99392_99392_5_WRB-BACE2_WRB_chr21_40763762_ENST00000398753_BACE2_chr21_42647298_ENST00000328735_length(amino acids)=96AA_BP=77
MSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQKLQVLQCLKFPG

--------------------------------------------------------------
>99392_99392_6_WRB-BACE2_WRB_chr21_40763762_ENST00000398753_BACE2_chr21_42647298_ENST00000347667_length(transcript)=7481nt_BP=333nt
GGATCCTCCTCCCGTCCTTCTCATCCTTCGTAAGTGGCTGCCTGGCCTCCCAAGGGCCGGTGGGGATGCCGCCCCAGTCCCCCGGCGGGT
CTGGCGTAGATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAGAGCGGAGATCCAGGACATGAAGCAGGAGCTCTCC
ACAGTCAACATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAACAAGATGACGGATAAGCTCAAAACCCATGTGAAA
GCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGTATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAA
TTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGATTGTGTCCTATG
CGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTG
AGGTCGTCAATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAACTCAGCTATTAA
GAAAATCACATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGAT
GCCTTCTAGATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAATAATTAAAAAAAAAACTTCA
TTCTAAACCAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCAAAGTGTCTACATGTGCCACCAACATAAAACAAAA
CCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATAGTTGATAACCCCTCTTAGCTTACAGGAAGCTTTT
TGTATTAATTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGGTACAGGAAGGCTTGCAGTATGATGGCAGGAGAAT
CAGCCTGGGGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGCCACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTG
AATGGGAGCCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTTCTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAG
AGGGGAAGGAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGAAAGTAAAAACACTACCTCTTTTGAGACTTTGCCC
AGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCACCCAAAAGAATTATCATCCCAACAGCCAAGACCC
AACAGGTGCTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACTATCACATATGCTTACTCTTGCTTAAAATTAATAA
ATCATGTTTTGATGAGAAAAAACTATTCTATTTCACTAGCTTAGTTGTCTCTTTTTCCAAATCTTCTCTGGAAGTAGGTTGGCTATTACC
CTGTTGGGAAACAGGGAAATGGCCTGATGCCCCTATTTCTGACCAGCTGTCAGGGAAGGAAGATGCAAGATGTGCAGAAGACACAAGGTA
ACGTCTACTTATCCCCGTGCTTCGAAACCGTGTGTTTCCCTTTGCAGAACTGGTTAGCCTCAAGCATACCCATCCAATCAGCTTAAATTG
TTCAGCAGTTGACCTCTGTGCTTCTTCCTTTGGGGGTGTTTAATCTTTGGTAACAGTTGTGCAGTGGTAGCCTTATTTCGGGGGGCAGTC
CCTACTTTCTGTCACTTATCGAGGCCTTTGCCAAAGAAAAGTGGAAGCCGTTTCCTTGACATAGCCTTATATGACCTGATGTCATTAGGA
GAAGAGTTAAAAGACAGTATCCCCTCTCTCCTGCTTGTGTGCCAAGTTCAGTGTTCCCTTTGCATTTTTTTGGGGTGGGTTGGCTATATT
ACAGAATTCCACCAAAAGTGCTAAGTGTCCCCTCCTGCAGAAGTATCGTTTGTATTCACAGTAGGCTACGTGTGGATGTTTCAGCCATCT
GCTCTGCTCCCTGGGTCCCCGGGTCACCACCATACTGAGAAATATAGGACTCTGCCAAAGAGACGTGGAGGCCACGTCGGCTTGTCATGG
TGTCCTGGAAGACTCTCCAGCAGCCAGAAGAACCTTCTGTGCTGTTTTCACTAGAGAAGATTTGAGTTGCAGCCTCTTGGAAAGAACATG
ACGGCACGGAACGGGAGGAGGGGGCTCTTGTATCAGGGCCCGTTGTCACATCCGCTCTCAGCTTGTTGAAAACTCATAATCTCAGAATGC
ATTTCACACGGAGAGATGTCTGGAAGTCCAATTCTCATCCCATTGGCTTTTTCCGTGGTTGCTGTTTTGTGGGCCGCTTTGCACAGGAGT
GAAGCCAACACCCCTAGATTGTGCCTTCACCCTTGCTGTGAAAAATTCAAAGCCCTGAAATAAGAGGAGGGAATCGCAGACATGCCCTGA
TTAGTTTTCCTGCTTATTTCTTCATACAGGCATCTTCTGTTCCGTTGTATTGTGTTAGGTTTCAGAGGCGGGGAGCTTCCTCCTGCAGCA
GATGAACAGGCATAGTTCTTAAAATACAGGAAAGTAACAAGTGAGGTTTCCAGGTAGAGTAGGTGAATGAAGTTTGCCGTCATGCTCTGT
ATTTCATATCAGATTTCTTTATCTTTTCATATCGCATGTCATTGGATGTGACATTTTGATGAAAATACTGAAACTACAAAAGCATAACTT
CGCAACAAGAATGAGATAGACAATTGAATGTGGGACATTTTTCTGGCATGTCTTGCTGCTGAGAATCGGACTTCCAGTCAAAACCCTGTT
AGTGACACCCACCTCCTCCAGTTATGCAAATTGATGCTTAGCTTGGCAAGCTTTCAAGGAGGTTTGCTTGGAACAGGAAAGGAATTAACA
ACCCTTTGAGGGTGTCATTTTTACCTTGTAATACACTGTGGAAAATTCTGGAAGACGGTCCTTGCCTGAAAAGGTGCAACTTAGCATTAG
GTTGTTATCAGAAACCTTGTCAAGTCTGATGGGAAATGAATAGATGCTGCTTTATTTCCTTGATAACTTCTTTGGAAGTCTGAAATAAAT
CCTGCCTTCAGTAACTGAAACCATTTATTAAAAATAGCAAGAAACAAGATGGGGACCAATTCTATTTTTATTCTTGGGAATTTGAAAGAG
CCACAAGTGATTGGTGTCCGATCTCCCAGCATATACTGTACACTATTTTGTATTTCTCCTGAACCAAAACCAAGTACTTAGCACTCAAGA
AACAGATGCCCTGTGTGTGACCGAGGGGAGTGTTTTTCCACAACAGGTTCCACTTCTGAACACTTGGAAGGACCTTGCCTGATTCATGGT
GAAACACAGAGGTTTTGGTTGGAGATAAATTTGGGGTCAGTTACTGTTCAAAATTGTGAAAGTAGTTCCCAGGAAGACAGCATTAGTGAC
TCCGCAGTGCTTTGGGTAATAGATTTTGAAAAGCAATTGTGAGTTGGGGATTCCATCATTTCATTTAAGAGGTGAAGAGGGATTTAATTA
TTTAATACGCCGGGTGCAAACTTGTTAAATTCCTCTTTCCCTGTCCCTGCTTGGTGGAGCTGCCACGTGTGGTTCAGTTCTAAGTTCTGG
ACTAGTGCCACTCGATATCATTGGGAATAAATCGTTGTTCAACAGTCTGTTCCACAAACAACAGTAATTGAATTTCACAGACTTTATCCT
GATTAGTGGAAATCAAATAATGGAGTGGAATCCCCATGTGTTTTCTCTTGCACAAACTTATTAGACTTGATTAGAAAACTGTTTGGAGGA
AAAACTTGCCAGTAAGTTTTTTGGTTGTTGTTTTGTTTTTTTTGAAAAACGACGCAACACCATAAAGTGTAAAATTAGGGGTTCTGGCCA
AGAGAGGTACTAGATTTTTTTAATGCCGAGAAAAGTCCATGCCACAGAAGTTATTGTGTATGTCTCTAGGGAGCTTTAAGAATTTCACGT
TTGAACTTTACAGCTGTTTACCAATTAAATGGCAAGCTGGAAAAATACATTTTGAGAGGGGTAGAAAGAATAAGAATATAATTAAAAGTA
TGCTAACAAAATAAGCAGTACATATTTTTTTAGAAAATGCAGTTTAGGCCAGGCACGGTAGCTCGTGCCTGTAATCCCAGCACTTTGGGA
GGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGACAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAA
TTAGCCAACGATGGTGATGCCTGTCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCGCTTGAACCGGGGAGGCAGAGGTTGT
AGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCGTCTCAAAAAAGGAAAGAAAATGCAGTTTCATTCCA
GCCATCCTTAGATTTCTTTTCCCCTTAAAGTGGCTGAATCCATTGGAGATGTGATTTATTTTGCAGATCCACCAATTCCAAACTTCAGGA
ATATTCAAGCGGGAGTCATGTGTAAGTGACAGCTTTGACAAAGAGAGACTGTGGCTGGGTGGCCCGGGTGTTGCCCACGCGGAGCAAGGA
TTGGTTCATTCAACGGATGGAGAGTACAGGATGGCTGGGACCTGGGAAGTTCCAGAATCTGAAAAGAGGGCAGGGCAAGAAGGAGCCAGA
AGAGAGGTCCCACCCCTCAGTTGGCAGTGGGGCACGGAGGTCCGCATCAGCCAAGAACGTCCCCAGGATGCCGTGGGCACCTCATTTCAC
CCCACGTTTTTGGCACAGTCTACTTTTTAGGTATTTTGTAAAGGAACTTCTCAGGATTGATTATTTGCCAGAGGAACAATTAGGCCAAGA
GAAACTTGCTTGACAGCCATGTGTAAAACACGTCTGTCCTAATCAAACTAGAGATGCCTCAAGGCCCACGCAGGACACAGGCAGGTTCAA
GGTCATGCACCTGGAAATTTGTAGGGGAGGGTCAAGCAACTGAGGCCAAAGGGGGCCGGTAAAGTGGCTTCTGGGGTCTGAGCATCTGGA
AGGCTCCTGGCAGCAGTTACCTGACAGTGTCGTTGAGGGGCACGGCAGCTGGGCCCTCACCGTTTCCGCCAGCTCTGCTGAGCCAGCCCA
GCCCATGCATTCCGAACATCCGACAGCTTCTTTCTCCAGAATGTCTTCTGTCAGAGACTTCCAGGAAAGGAGCTCCCTCCTGTCTCACTG
CTGTCAGCGTGGGAGCCCTGCTCCCCAGGCTCCACGTCCCCGGAAGGTCCATCTTGTCCTGGAGCACACCCAGCCCCATTCAGGGTCAGT
GCAGGAGGGAACAGGGAATCTGCATTTCAGTAAGCTCCCCAGGTGAGGCTGCAGAGCAGAAACCACGGCTTTCAGACGTGAGCAGGCTCC
CTGGGCTCTTGGTGTCACCCTGTTAGCCACATCTGCGGAATGTGGAAGGCAGAACATAGCCACGCTGCTTAGTGCTGCCAGCGAACCTCA
GGTTGCATCAGTGGCTGGAATCTATCACAGCTGTTGGGGATACGTAACTCCCAGCAATAAATCCAGTATTTTCTTCCCTGCCCTGAGCTT
CCTCTGGGTTTCTTATCAGCAGCTATTACACACAGATGTCCAGTGCTTCTAAACTAAATTGTACTGTGTAACTTTTACATCACACTTGTG
TGCTTAAAAAGCACACCGTGGGTAGTGACTGGGCCAAGAGACATCACAAAGCTTCCTGATAAATTTGAATCCAGCCACGGCAAGAGCGAC
GTGCGGGTACCTGGTCCCTGATGCTTGGGTGCCCCGTTGAGCCTCGGGTACTTCTTGGACACTATTGTGAGAGCAGCCATCCTGGTGTCT
CTGCCAGCATCTTGGGGAACGCTGTGATGGTAAAATATCTGTCTCTCCTCTGGGAATCAGGGCAGCCCTGAGAAGTGAGCAGTTCCCTTT
ACAGATGGATAATTGTTTGTGTAAGACCAACCAGATAAAGTCCAAACTGTGTAGAACACACGTGTGCCTCACACATAGCCATCTGAGTAA
AATATTTTTTCCAATGTAGATTTATAATTAGAAATGACAGATTTATAATATAGACTTCAGTAAGTTGGGCACAGCTGTCACTTTCGTGGT
ATCAATAAAAGGCTAGAAACCTTGGGTGTCCTTGGCAACCTAGCCTTTGACATTGATGTTTTTCCATAGGATTTTCTTCATTTGGGTTGG
AATAAAAATGCATTTTTATTCACAAGGCACAGACAGATAAGAATATCATAAGCAGGGAAGTGTCTCCAAAGGTCAGGACATATGTTTTTC
TGTTGAGTGCTATATGTGGAGGTCATTGCAAGTTCCCTGATATGAGTATGGTTTCGCTTGCTACATTGTGCCTATTAAAGTAAAATTTTA
CACAAGCCTCGCATTTCTAAGATTAGTGTTCCTGAATGAAATGTTAAGAAAACATTAAAAGATTATCTCTTTTTAAGATGGAGGAAAAAA
AGTGAACAAAGCTAATTAATCTATCATGAAAATTGCACAAAATAACATTTCTTAACAAATTTAATACAATTTTGTGTTCTTTGTTGCTAG
TGGTATAAAACGAGATTTTTTTCCCTCATTTTTCTCATTGTAGATGTCATCTCTCACATTTATATCAGTGAGGTTTGAAATTCTGTGTAG
CAGTTACTCAGCACATATGAGAGGGCAGCGAATGAATGAGATTTGTCATGTGCTAATAAAAGCTGAATTTTTGTAATCTAAAATGATGTA
TTTTCTACTATTGCTGTTAATTTGCATTGTTAAAAATTCTTAAAGTTTAATATGTTATGTTCAGTCATTGAAAGCGACCACTCATTTTTT
TCTTAAAGTTGATGCCTTTTCTGCTGTGCTAGAGTCAGTATTTTGCTTCTGGCAGGAGAGCTGCAAACTGTGTATCCTCAAACAGATGCA
AAAAGTAGTGCTTTGCAAAACGTTTGTTTTCTGTTTATCTCAGATTAACATCCTTTAATACAAGTTTCTTAAGTGTAACTTGTATTTCTG
AAAATGCTTAAAATTATTTTATATTTCCCTTTGGGAATTTTTCTCTATTTCCAGCACGCTGATTTGATTTAAAAATGTAATAAGACCAAG
AGTTGGAGTAAAGGGATATTCATTCCATGTTAAAAGTGGCTTCATAGCTACTGACAAATGTCTGAACTATTGTCGTGCCCTTCAAAACTG
GAGTTTTCTAAAATAATCTTATTTTTATACTTGTATGTTCCAGCAATTTAAGATATATACCATTGAAAGGGAAATAAAACATTTTTGTTT

>99392_99392_6_WRB-BACE2_WRB_chr21_40763762_ENST00000398753_BACE2_chr21_42647298_ENST00000347667_length(amino acids)=132AA_BP=
MSIWKAPGSSYLTVSLRGTAAGPSPFPPALLSQPSPCIPNIRQLLSPECLLSETSRKGAPSCLTAVSVGALLPRLHVPGRSILSWSTPSP

--------------------------------------------------------------
>99392_99392_7_WRB-BACE2_WRB_chr21_40763762_ENST00000541890_BACE2_chr21_42647298_ENST00000328735_length(transcript)=1594nt_BP=367nt
AGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTGGTGCTCAGCTTCGTGTTTGG
ATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAG
AGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAACATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAA
CAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGT
ATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCT
TTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTG
CCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCAATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGG
CCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCACATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGC
CCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTAGATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCT
ACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAACCAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCA
AAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATA
GTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAATTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGG
TACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGGGGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGC
CACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAGCCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTT
CTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAGGAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGA
AAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCA
CCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTGCTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACT

>99392_99392_7_WRB-BACE2_WRB_chr21_40763762_ENST00000541890_BACE2_chr21_42647298_ENST00000328735_length(amino acids)=130AA_BP=111
MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHV

--------------------------------------------------------------
>99392_99392_8_WRB-BACE2_WRB_chr21_40763762_ENST00000541890_BACE2_chr21_42647298_ENST00000347667_length(transcript)=7515nt_BP=367nt
AGCGGACCCAGCACAGCCAGGAGCGTCCGGGATGAGCTCAGCCGCGGCCGACCACTGGGCGTGGTTGCTGGTGCTCAGCTTCGTGTTTGG
ATGCAATGTTCTTAGGATCCTCCTCCCGTCCTTCTCATCCTTCATGTCCAGGGTGCTGCAGAAGGACGCGGAGCAGGAGTCACAGATGAG
AGCGGAGATCCAGGACATGAAGCAGGAGCTCTCCACAGTCAACATGATGGACGAGTTTGCCAGATATGCCAGGCTGGAAAGAAAGATCAA
CAAGATGACGGATAAGCTCAAAACCCATGTGAAAGCTCGGACAGCTCAATTAGCCAAGATAAAATGGGTGATAAGTGTCGCTTTCTACGT
ATTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAACAGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCT
TTGAGCGAGCCCATTTTGTGGATTGTGTCCTATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCTGCTGCTG
CCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCAATGATGAGTCCTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGG
CCTGACCTCAAGCAACCATGAACTCAGCTATTAAGAAAATCACATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCTCCTGTGC
CCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTAGATTCACTGTCTTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCT
ACTTCCAAGAAAAATAATTAAAAAAAAAACTTCATTCTAAACCAAAACAGAGTGGATTGGGCTGCAGGCTCTATGGGGTTCGTTATGCCA
AAGTGTCTACATGTGCCACCAACATAAAACAAAACCAAGCCTTGGCTCGTTCTCTTCTCTCTTCAATCTCTGGAAAAATAAGTACATATA
GTTGATAACCCCTCTTAGCTTACAGGAAGCTTTTTGTATTAATTGCCTTTGAGGTTATTTTCCGCCAGACCTCAACCTGGGTCAAAGTGG
TACAGGAAGGCTTGCAGTATGATGGCAGGAGAATCAGCCTGGGGCCTGGGGATGTAACCAAGCTGTACCCTTGAGACCTGGAACCAGAGC
CACAGGCCCCTTTTGTGGGTTTCTCTGTGCTCTGAATGGGAGCCAGAATTCACTAGGAGGTCATCAACCGATGGTCCTCACAAGCCTCTT
CTGAAGATGGAAGGCCTTTTGCCCGTTGAGGTAGAGGGGAAGGAAATCTCCTCTTTTGTACCCAATACTTATGTTGTATTGTTGGTGCGA
AAGTAAAAACACTACCTCTTTTGAGACTTTGCCCAGGGTCCTGTGCCTGGATGGGGGTGCAGGCAGCCTTGACCACGGCTGTTCCCCTCA
CCCAAAAGAATTATCATCCCAACAGCCAAGACCCAACAGGTGCTGAACTGTGCATCAACCAGGAAGAGTTCTATCCCCAAGCTGGCCACT
ATCACATATGCTTACTCTTGCTTAAAATTAATAAATCATGTTTTGATGAGAAAAAACTATTCTATTTCACTAGCTTAGTTGTCTCTTTTT
CCAAATCTTCTCTGGAAGTAGGTTGGCTATTACCCTGTTGGGAAACAGGGAAATGGCCTGATGCCCCTATTTCTGACCAGCTGTCAGGGA
AGGAAGATGCAAGATGTGCAGAAGACACAAGGTAACGTCTACTTATCCCCGTGCTTCGAAACCGTGTGTTTCCCTTTGCAGAACTGGTTA
GCCTCAAGCATACCCATCCAATCAGCTTAAATTGTTCAGCAGTTGACCTCTGTGCTTCTTCCTTTGGGGGTGTTTAATCTTTGGTAACAG
TTGTGCAGTGGTAGCCTTATTTCGGGGGGCAGTCCCTACTTTCTGTCACTTATCGAGGCCTTTGCCAAAGAAAAGTGGAAGCCGTTTCCT
TGACATAGCCTTATATGACCTGATGTCATTAGGAGAAGAGTTAAAAGACAGTATCCCCTCTCTCCTGCTTGTGTGCCAAGTTCAGTGTTC
CCTTTGCATTTTTTTGGGGTGGGTTGGCTATATTACAGAATTCCACCAAAAGTGCTAAGTGTCCCCTCCTGCAGAAGTATCGTTTGTATT
CACAGTAGGCTACGTGTGGATGTTTCAGCCATCTGCTCTGCTCCCTGGGTCCCCGGGTCACCACCATACTGAGAAATATAGGACTCTGCC
AAAGAGACGTGGAGGCCACGTCGGCTTGTCATGGTGTCCTGGAAGACTCTCCAGCAGCCAGAAGAACCTTCTGTGCTGTTTTCACTAGAG
AAGATTTGAGTTGCAGCCTCTTGGAAAGAACATGACGGCACGGAACGGGAGGAGGGGGCTCTTGTATCAGGGCCCGTTGTCACATCCGCT
CTCAGCTTGTTGAAAACTCATAATCTCAGAATGCATTTCACACGGAGAGATGTCTGGAAGTCCAATTCTCATCCCATTGGCTTTTTCCGT
GGTTGCTGTTTTGTGGGCCGCTTTGCACAGGAGTGAAGCCAACACCCCTAGATTGTGCCTTCACCCTTGCTGTGAAAAATTCAAAGCCCT
GAAATAAGAGGAGGGAATCGCAGACATGCCCTGATTAGTTTTCCTGCTTATTTCTTCATACAGGCATCTTCTGTTCCGTTGTATTGTGTT
AGGTTTCAGAGGCGGGGAGCTTCCTCCTGCAGCAGATGAACAGGCATAGTTCTTAAAATACAGGAAAGTAACAAGTGAGGTTTCCAGGTA
GAGTAGGTGAATGAAGTTTGCCGTCATGCTCTGTATTTCATATCAGATTTCTTTATCTTTTCATATCGCATGTCATTGGATGTGACATTT
TGATGAAAATACTGAAACTACAAAAGCATAACTTCGCAACAAGAATGAGATAGACAATTGAATGTGGGACATTTTTCTGGCATGTCTTGC
TGCTGAGAATCGGACTTCCAGTCAAAACCCTGTTAGTGACACCCACCTCCTCCAGTTATGCAAATTGATGCTTAGCTTGGCAAGCTTTCA
AGGAGGTTTGCTTGGAACAGGAAAGGAATTAACAACCCTTTGAGGGTGTCATTTTTACCTTGTAATACACTGTGGAAAATTCTGGAAGAC
GGTCCTTGCCTGAAAAGGTGCAACTTAGCATTAGGTTGTTATCAGAAACCTTGTCAAGTCTGATGGGAAATGAATAGATGCTGCTTTATT
TCCTTGATAACTTCTTTGGAAGTCTGAAATAAATCCTGCCTTCAGTAACTGAAACCATTTATTAAAAATAGCAAGAAACAAGATGGGGAC
CAATTCTATTTTTATTCTTGGGAATTTGAAAGAGCCACAAGTGATTGGTGTCCGATCTCCCAGCATATACTGTACACTATTTTGTATTTC
TCCTGAACCAAAACCAAGTACTTAGCACTCAAGAAACAGATGCCCTGTGTGTGACCGAGGGGAGTGTTTTTCCACAACAGGTTCCACTTC
TGAACACTTGGAAGGACCTTGCCTGATTCATGGTGAAACACAGAGGTTTTGGTTGGAGATAAATTTGGGGTCAGTTACTGTTCAAAATTG
TGAAAGTAGTTCCCAGGAAGACAGCATTAGTGACTCCGCAGTGCTTTGGGTAATAGATTTTGAAAAGCAATTGTGAGTTGGGGATTCCAT
CATTTCATTTAAGAGGTGAAGAGGGATTTAATTATTTAATACGCCGGGTGCAAACTTGTTAAATTCCTCTTTCCCTGTCCCTGCTTGGTG
GAGCTGCCACGTGTGGTTCAGTTCTAAGTTCTGGACTAGTGCCACTCGATATCATTGGGAATAAATCGTTGTTCAACAGTCTGTTCCACA
AACAACAGTAATTGAATTTCACAGACTTTATCCTGATTAGTGGAAATCAAATAATGGAGTGGAATCCCCATGTGTTTTCTCTTGCACAAA
CTTATTAGACTTGATTAGAAAACTGTTTGGAGGAAAAACTTGCCAGTAAGTTTTTTGGTTGTTGTTTTGTTTTTTTTGAAAAACGACGCA
ACACCATAAAGTGTAAAATTAGGGGTTCTGGCCAAGAGAGGTACTAGATTTTTTTAATGCCGAGAAAAGTCCATGCCACAGAAGTTATTG
TGTATGTCTCTAGGGAGCTTTAAGAATTTCACGTTTGAACTTTACAGCTGTTTACCAATTAAATGGCAAGCTGGAAAAATACATTTTGAG
AGGGGTAGAAAGAATAAGAATATAATTAAAAGTATGCTAACAAAATAAGCAGTACATATTTTTTTAGAAAATGCAGTTTAGGCCAGGCAC
GGTAGCTCGTGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGACAACAT
GGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAACGATGGTGATGCCTGTCTGTAATCCCAGCTACTCTGGAGGCTGAGGCA
GGAGAATCGCTTGAACCGGGGAGGCAGAGGTTGTAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCGT
CTCAAAAAAGGAAAGAAAATGCAGTTTCATTCCAGCCATCCTTAGATTTCTTTTCCCCTTAAAGTGGCTGAATCCATTGGAGATGTGATT
TATTTTGCAGATCCACCAATTCCAAACTTCAGGAATATTCAAGCGGGAGTCATGTGTAAGTGACAGCTTTGACAAAGAGAGACTGTGGCT
GGGTGGCCCGGGTGTTGCCCACGCGGAGCAAGGATTGGTTCATTCAACGGATGGAGAGTACAGGATGGCTGGGACCTGGGAAGTTCCAGA
ATCTGAAAAGAGGGCAGGGCAAGAAGGAGCCAGAAGAGAGGTCCCACCCCTCAGTTGGCAGTGGGGCACGGAGGTCCGCATCAGCCAAGA
ACGTCCCCAGGATGCCGTGGGCACCTCATTTCACCCCACGTTTTTGGCACAGTCTACTTTTTAGGTATTTTGTAAAGGAACTTCTCAGGA
TTGATTATTTGCCAGAGGAACAATTAGGCCAAGAGAAACTTGCTTGACAGCCATGTGTAAAACACGTCTGTCCTAATCAAACTAGAGATG
CCTCAAGGCCCACGCAGGACACAGGCAGGTTCAAGGTCATGCACCTGGAAATTTGTAGGGGAGGGTCAAGCAACTGAGGCCAAAGGGGGC
CGGTAAAGTGGCTTCTGGGGTCTGAGCATCTGGAAGGCTCCTGGCAGCAGTTACCTGACAGTGTCGTTGAGGGGCACGGCAGCTGGGCCC
TCACCGTTTCCGCCAGCTCTGCTGAGCCAGCCCAGCCCATGCATTCCGAACATCCGACAGCTTCTTTCTCCAGAATGTCTTCTGTCAGAG
ACTTCCAGGAAAGGAGCTCCCTCCTGTCTCACTGCTGTCAGCGTGGGAGCCCTGCTCCCCAGGCTCCACGTCCCCGGAAGGTCCATCTTG
TCCTGGAGCACACCCAGCCCCATTCAGGGTCAGTGCAGGAGGGAACAGGGAATCTGCATTTCAGTAAGCTCCCCAGGTGAGGCTGCAGAG
CAGAAACCACGGCTTTCAGACGTGAGCAGGCTCCCTGGGCTCTTGGTGTCACCCTGTTAGCCACATCTGCGGAATGTGGAAGGCAGAACA
TAGCCACGCTGCTTAGTGCTGCCAGCGAACCTCAGGTTGCATCAGTGGCTGGAATCTATCACAGCTGTTGGGGATACGTAACTCCCAGCA
ATAAATCCAGTATTTTCTTCCCTGCCCTGAGCTTCCTCTGGGTTTCTTATCAGCAGCTATTACACACAGATGTCCAGTGCTTCTAAACTA
AATTGTACTGTGTAACTTTTACATCACACTTGTGTGCTTAAAAAGCACACCGTGGGTAGTGACTGGGCCAAGAGACATCACAAAGCTTCC
TGATAAATTTGAATCCAGCCACGGCAAGAGCGACGTGCGGGTACCTGGTCCCTGATGCTTGGGTGCCCCGTTGAGCCTCGGGTACTTCTT
GGACACTATTGTGAGAGCAGCCATCCTGGTGTCTCTGCCAGCATCTTGGGGAACGCTGTGATGGTAAAATATCTGTCTCTCCTCTGGGAA
TCAGGGCAGCCCTGAGAAGTGAGCAGTTCCCTTTACAGATGGATAATTGTTTGTGTAAGACCAACCAGATAAAGTCCAAACTGTGTAGAA
CACACGTGTGCCTCACACATAGCCATCTGAGTAAAATATTTTTTCCAATGTAGATTTATAATTAGAAATGACAGATTTATAATATAGACT
TCAGTAAGTTGGGCACAGCTGTCACTTTCGTGGTATCAATAAAAGGCTAGAAACCTTGGGTGTCCTTGGCAACCTAGCCTTTGACATTGA
TGTTTTTCCATAGGATTTTCTTCATTTGGGTTGGAATAAAAATGCATTTTTATTCACAAGGCACAGACAGATAAGAATATCATAAGCAGG
GAAGTGTCTCCAAAGGTCAGGACATATGTTTTTCTGTTGAGTGCTATATGTGGAGGTCATTGCAAGTTCCCTGATATGAGTATGGTTTCG
CTTGCTACATTGTGCCTATTAAAGTAAAATTTTACACAAGCCTCGCATTTCTAAGATTAGTGTTCCTGAATGAAATGTTAAGAAAACATT
AAAAGATTATCTCTTTTTAAGATGGAGGAAAAAAAGTGAACAAAGCTAATTAATCTATCATGAAAATTGCACAAAATAACATTTCTTAAC
AAATTTAATACAATTTTGTGTTCTTTGTTGCTAGTGGTATAAAACGAGATTTTTTTCCCTCATTTTTCTCATTGTAGATGTCATCTCTCA
CATTTATATCAGTGAGGTTTGAAATTCTGTGTAGCAGTTACTCAGCACATATGAGAGGGCAGCGAATGAATGAGATTTGTCATGTGCTAA
TAAAAGCTGAATTTTTGTAATCTAAAATGATGTATTTTCTACTATTGCTGTTAATTTGCATTGTTAAAAATTCTTAAAGTTTAATATGTT
ATGTTCAGTCATTGAAAGCGACCACTCATTTTTTTCTTAAAGTTGATGCCTTTTCTGCTGTGCTAGAGTCAGTATTTTGCTTCTGGCAGG
AGAGCTGCAAACTGTGTATCCTCAAACAGATGCAAAAAGTAGTGCTTTGCAAAACGTTTGTTTTCTGTTTATCTCAGATTAACATCCTTT
AATACAAGTTTCTTAAGTGTAACTTGTATTTCTGAAAATGCTTAAAATTATTTTATATTTCCCTTTGGGAATTTTTCTCTATTTCCAGCA
CGCTGATTTGATTTAAAAATGTAATAAGACCAAGAGTTGGAGTAAAGGGATATTCATTCCATGTTAAAAGTGGCTTCATAGCTACTGACA
AATGTCTGAACTATTGTCGTGCCCTTCAAAACTGGAGTTTTCTAAAATAATCTTATTTTTATACTTGTATGTTCCAGCAATTTAAGATAT

>99392_99392_8_WRB-BACE2_WRB_chr21_40763762_ENST00000541890_BACE2_chr21_42647298_ENST00000347667_length(amino acids)=132AA_BP=
MSIWKAPGSSYLTVSLRGTAAGPSPFPPALLSQPSPCIPNIRQLLSPECLLSETSRKGAPSCLTAVSVGALLPRLHVPGRSILSWSTPSP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for WRB-BACE2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	WRB	chr21:40763762	chr21:42647298	ENST00000333781	+	3	5	39_97	112.0	175.0	GET3/TRC40

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	WRB	chr21:40763762	chr21:42647298	ENST00000380708	+	3	5	39_97	78.0	141.0	GET3/TRC40
Hgene	WRB	chr21:40763762	chr21:42647298	ENST00000398753	+	3	5	39_97	78.0	141.0	GET3/TRC40

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for WRB-BACE2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for WRB-BACE2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source