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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:WRN-ADAM9 (FusionGDB2 ID:99398)

Fusion Gene Summary for WRN-ADAM9

Fusion gene summary

Fusion gene information	Fusion gene name: WRN-ADAM9
	Fusion gene ID: 99398
		Hgene	Tgene
	Gene symbol	WRN	ADAM9
	Gene ID	7486	8754
	Gene name	WRN RecQ like helicase	ADAM metallopeptidase domain 9
	Synonyms	RECQ3\|RECQL2\|RECQL3	CORD9\|MCMP\|MDC9\|Mltng
	Cytomap	8p12	8p11.22
	Type of gene	protein-coding	protein-coding
	Description	Werner syndrome ATP-dependent helicaseDNA helicase, RecQ-like type 3Werner syndrome RecQ like helicaseWerner syndrome, RecQ helicase-likeexonuclease WRNrecQ protein-like 2	disintegrin and metalloproteinase domain-containing protein 9ADAM metallopeptidase domain 9 (meltrin gamma)cellular disintegrin-related proteincone rod dystrophy 9metalloprotease/disintegrin/cysteine-rich protein 9myeloma cell metalloproteinase
	Modification date	20200320	20200313
	UniProtAcc	.	Q13443
	Ensembl transtripts involved in fusion gene	ENST00000298139,	ENST00000484143, ENST00000481513, ENST00000466936, ENST00000487273,
Fusion gene scores	* DoF score	8 X 6 X 6=288	12 X 12 X 8=1152
	# samples	8	13
	** MAII score	log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/1152*10)=-3.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: WRN [Title/Abstract] AND ADAM9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	WRN(30982516)-ADAM9(38871484), # samples:2
Anticipated loss of major functional domain due to fusion event.	WRN-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. WRN-ADAM9 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	WRN	GO:0000731	DNA synthesis involved in DNA repair	17563354
Hgene	WRN	GO:0006259	DNA metabolic process	16622405
Hgene	WRN	GO:0006284	base-excision repair	17611195
Hgene	WRN	GO:0006974	cellular response to DNA damage stimulus	18203716
Hgene	WRN	GO:0006979	response to oxidative stress	17611195
Hgene	WRN	GO:0009267	cellular response to starvation	11420665
Hgene	WRN	GO:0010225	response to UV-C	17563354
Hgene	WRN	GO:0031297	replication fork processing	17115688
Hgene	WRN	GO:0032508	DNA duplex unwinding	11735402\|26420422
Hgene	WRN	GO:0044806	G-quadruplex DNA unwinding	11735402
Hgene	WRN	GO:0051345	positive regulation of hydrolase activity	17611195
Hgene	WRN	GO:0061820	telomeric D-loop disassembly	15200954\|19734539\|26420422
Hgene	WRN	GO:0071480	cellular response to gamma radiation	21639834
Hgene	WRN	GO:0098530	positive regulation of strand invasion	26420422
Hgene	WRN	GO:1902570	protein localization to nucleolus	11420665
Tgene	ADAM9	GO:0000186	activation of MAPKK activity	17704059
Tgene	ADAM9	GO:0006509	membrane protein ectodomain proteolysis	9920899
Tgene	ADAM9	GO:0034612	response to tumor necrosis factor	11831872
Tgene	ADAM9	GO:0050714	positive regulation of protein secretion	17704059

Fusion gene breakpoints across WRN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADAM9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-B6-A0I1-01A	WRN	chr8	30982516	-	ADAM9	chr8	38871484	+
ChimerDB4	BRCA	TCGA-B6-A0I1-01A	WRN	chr8	30982516	+	ADAM9	chr8	38871484	+

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Fusion Gene ORF analysis for WRN-ADAM9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000298139	ENST00000484143	WRN	chr8	30982516	+	ADAM9	chr8	38871484	+
Frame-shift	ENST00000298139	ENST00000481513	WRN	chr8	30982516	+	ADAM9	chr8	38871484	+
In-frame	ENST00000298139	ENST00000466936	WRN	chr8	30982516	+	ADAM9	chr8	38871484	+
In-frame	ENST00000298139	ENST00000487273	WRN	chr8	30982516	+	ADAM9	chr8	38871484	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000298139

WRN

chr8

30982516

ENST00000487273

ADAM9

chr8

38871484

6581

3074

249

5279

1676

ENST00000298139

WRN

chr8

30982516

ENST00000466936

ADAM9

chr8

38871484

4678

3074

249

3263

1004

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000298139	ENST00000487273	WRN	chr8	30982516	+	ADAM9	chr8	38871484	+	9.57E-05	0.9999043
ENST00000298139	ENST00000466936	WRN	chr8	30982516	+	ADAM9	chr8	38871484	+	8.70E-05	0.999913

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Fusion Genomic Features for WRN-ADAM9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
WRN	chr8	30982516	+	ADAM9	chr8	38871483	+	0.000213238	0.9997868
WRN	chr8	30982516	+	ADAM9	chr8	38871483	+	0.000213238	0.9997868

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WRN-ADAM9

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:30982516/chr8:38871484)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ADAM9 Q13443
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250\|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269\|PubMed:12054541}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

WRN

chr8:30982516

chr8:38871484

ENST00000298139

507_510

941

1433.0

Compositional bias

Note=Poly-Glu

Hgene

WRN

chr8:30982516

chr8:38871484

ENST00000298139

558_724

941

1433.0

Domain

Helicase ATP-binding

Hgene

WRN

chr8:30982516

chr8:38871484

ENST00000298139

60_228

941

1433.0

Domain

Note=3'-5' exonuclease

Hgene

WRN

chr8:30982516

chr8:38871484

ENST00000298139

749_899

941

1433.0

Domain

Helicase C-terminal

Hgene

WRN

chr8:30982516

chr8:38871484

ENST00000298139

668_671

941

1433.0

Motif

Note=DEAH box

Hgene

WRN

chr8:30982516

chr8:38871484

ENST00000298139

571_578

941

1433.0

Nucleotide binding

ATP

Hgene

WRN

chr8:30982516

chr8:38871484

ENST00000298139

424_477

941

1433.0

Region

Note=2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K

Hgene

WRN

chr8:30982516

chr8:38871484

ENST00000298139

424_450

941

1433.0

Repeat

Hgene

WRN

chr8:30982516

chr8:38871484

ENST00000298139

451_477

941

1433.0

Repeat

Tgene

ADAM9

chr8:30982516

chr8:38871484

ENST00000487273

505_634

820.0

Compositional bias

Note=Cys-rich

Tgene

ADAM9

chr8:30982516

chr8:38871484

ENST00000487273

790_795

820.0

Compositional bias

Note=Poly-Pro

Tgene

ADAM9

chr8:30982516

chr8:38871484

ENST00000487273

212_406

820.0

Domain

Peptidase M12B

Tgene

ADAM9

chr8:30982516

chr8:38871484

ENST00000487273

414_501

820.0

Domain

Disintegrin

Tgene

ADAM9

chr8:30982516

chr8:38871484

ENST00000487273

644_698

820.0

Domain

EGF-like

Tgene

ADAM9

chr8:30982516

chr8:38871484

ENST00000487273

719_819

820.0

Topological domain

Cytoplasmic

Tgene

ADAM9

chr8:30982516

chr8:38871484

ENST00000487273

698_718

820.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

WRN

chr8:30982516

chr8:38871484

ENST00000298139

1150_1229

941

1433.0

Domain

HRDC

Tgene

ADAM9

chr8:30982516

chr8:38871484

ENST00000487273

29_697

820.0

Topological domain

Extracellular

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Fusion Gene Sequence for WRN-ADAM9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>99398_99398_1_WRN-ADAM9_WRN_chr8_30982516_ENST00000298139_ADAM9_chr8_38871484_ENST00000466936_length(transcript)=4678nt_BP=3074nt
GGAGCTGATGTGTACTGTGTGCGCCGGGGAGGCGCCGGCTTGTACTCGGCAGCGCGGGAATAAAGTTTGCTGATTTGGTGTCTAGCCTGG
ATGCCTGGGTTGCAGGCCCTGCTTGTGGTGGCGCTCCACAGTCATCCGGCTGAAGAAGACCTGTTGGACTGGATCTTCTCGGGTTTTCTT
TCAGATATTGTTTTGTATTTACCCATGAAGACATTGTTTTTTGGACTCTGCAAATAGGACATTTCAAAGATGAGTGAAAAAAAATTGGAA
ACAACTGCACAGCAGCGGAAATGTCCTGAATGGATGAATGTGCAGAATAAAAGATGTGCTGTAGAAGAAAGAAAGGCATGTGTTCGGAAG
AGTGTTTTTGAAGATGACCTCCCCTTCTTAGAATTCACTGGATCCATTGTGTATAGTTACGATGCTAGTGATTGCTCTTTCCTGTCAGAA
GATATTAGCATGAGTCTATCAGATGGGGATGTGGTGGGATTTGACATGGAGTGGCCACCATTATACAATAGAGGGAAACTTGGCAAAGTT
GCACTAATTCAGTTGTGTGTTTCTGAGAGCAAATGTTACTTGTTCCACGTTTCTTCCATGTCAGTTTTTCCCCAGGGATTAAAAATGTTG
CTTGAAAATAAAGCAGTTAAAAAGGCAGGTGTAGGAATTGAAGGAGATCAGTGGAAACTTCTACGTGACTTTGATATCAAATTGAAGAAT
TTTGTGGAGTTGACAGATGTTGCCAATAAAAAGCTGAAATGCACAGAGACCTGGAGCCTTAACAGTCTGGTTAAACACCTCTTAGGTAAA
CAGCTCCTGAAAGACAAGTCTATCCGCTGTAGCAATTGGAGTAAATTTCCTCTCACTGAGGACCAGAAACTGTATGCAGCCACTGATGCT
TATGCTGGTTTTATTATTTACCGAAATTTAGAGATTTTGGATGATACTGTGCAAAGGTTTGCTATAAATAAAGAGGAAGAAATCCTACTT
AGCGACATGAACAAACAGTTGACTTCAATCTCTGAGGAAGTGATGGATCTGGCTAAGCATCTTCCTCATGCTTTCAGTAAATTGGAAAAC
CCACGGAGGGTTTCTATCTTACTAAAGGATATTTCAGAAAATCTATATTCACTGAGGAGGATGATAATTGGGTCTACTAACATTGAGACT
GAACTGAGGCCCAGCAATAATTTAAACTTATTATCCTTTGAAGATTCAACTACTGGGGGAGTACAACAGAAACAAATTAGAGAACATGAA
GTTTTAATTCACGTTGAAGATGAAACATGGGACCCAACACTTGATCATTTAGCTAAACATGATGGAGAAGATGTACTTGGAAATAAAGTG
GAACGAAAAGAAGATGGATTTGAAGATGGAGTAGAAGACAACAAATTGAAAGAGAATATGGAAAGAGCTTGTTTGATGTCGTTAGATATT
ACAGAACATGAACTCCAAATTTTGGAACAGCAGTCTCAGGAAGAATATCTTAGTGATATTGCTTATAAATCTACTGAGCATTTATCTCCC
AATGATAATGAAAACGATACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGCATTTATCTCCCAATGATAAT
GAAAACGATACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGTCTTTAGAAAACCTCAATAGTGGCACGGTA
GAACCAACTCATTCTAAATGCTTAAAAATGGAAAGAAATCTGGGTCTTCCTACTAAAGAAGAAGAAGAAGATGATGAAAATGAAGCTAAT
GAAGGGGAAGAAGATGATGATAAGGACTTTTTGTGGCCAGCACCCAATGAAGAGCAAGTTACTTGCCTCAAGATGTACTTTGGCCATTCC
AGTTTTAAACCAGTTCAGTGGAAAGTGATTCATTCAGTATTAGAAGAAAGAAGAGATAATGTTGCTGTCATGGCAACTGGATATGGAAAG
AGTTTGTGCTTCCAGTATCCACCTGTTTATGTAGGCAAGATTGGCCTTGTTATCTCTCCCCTTATTTCTCTGATGGAAGACCAAGTGCTA
CAGCTTAAAATGTCCAACATCCCAGCTTGCTTCCTTGGATCAGCACAGTCAGAAAATGTTCTAACAGATATTAAATTAGGTAAATACCGG
ATTGTATACGTAACTCCAGAATACTGTTCAGGTAACATGGGCCTGCTCCAGCAACTTGAGGCTGATATTGGTATCACGCTCATTGCTGTG
GATGAGGCTCACTGTATTTCTGAGTGGGGGCATGATTTTAGGGATTCATTCAGGAAGTTGGGCTCCCTAAAGACAGCACTGCCAATGGTT
CCAATCGTTGCACTTACTGCTACTGCAAGTTCTTCAATCCGGGAAGACATTGTACGTTGCTTAAATCTGAGAAATCCTCAGATCACCTGT
ACTGGTTTTGATCGACCAAACCTGTATTTAGAAGTTAGGCGAAAAACAGGGAATATCCTTCAGGATCTGCAGCCATTTCTTGTCAAAACA
AGTTCCCACTGGGAATTTGAAGGTCCAACAATCATCTACTGTCCTTCTAGAAAAATGACACAACAAGTTACAGGTGAACTTAGGAAACTG
AATCTATCCTGTGGAACATACCATGCGGGCATGAGTTTTAGCACAAGGAAAGACATTCATCATAGGTTTGTAAGAGATGAAATTCAGTGT
GTCATAGCTACCATAGCTTTTGGAATGGGCATTAATAAAGCTGACATTCGCCAAGTCATTCATTACGGTGCTCCTAAGGACATGGAATCA
TATTATCAGGAGATTGGTAGAGCTGGTCGTGATGGACTTCAAAGTTCTTGTCACGTCCTCTGGGCTCCTGCAGACATTAACTTAAATAGG
CACCTTCTTACTGAGATACGTAATGAGAAGTTTCGATTATACAAATTAAAGATGATGGCAAAGATGGAAAAATATCTTCATTCTAGCAGA
TGTAGGAGACAAATCATCTTGTCTCATTTTGAGGACAAACAAGTACAAAAAGCCTCCTTGGGAATTATGGGAACTGAAAAATGCTGTGAT
AATTGCAGGTCCAGAGACCTTTTGCCTGAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATA
CAGAGGTGTGGTCCTCTCTGCATCAGAGAACAGAGTACTCCTGGGGACAGAGCTGGCCAGAATACCCAAAATAATTGGCAGATGTCAAAT
TTGGCTTTCTGTGTTTATTACTAGAGCATAAACATTTCTAGTTTTGTTTGAGTGTTTTACAGTCCTTTTTGGCAGTTAGGTATTATACCT
TTTTTTCTTTTGCAATGGTTTTCATGAGAAATCTTTATTCCCATTACATGTGTATGTTTTATTTTTCTTCTGAACTTTGTAATACTTTGC
TATGTTGAATTGTTTCTGTTGGTAGCGCACTTTTGCAGCATTCTTCAAATAGGAGGCAAAAAAATCTTTAGATTAATTATTAGTACTTAC
AAAAACCAAGGAAATGCTGACTTAGGCCTATCTTCTGGTCCACTATCTGATTTCTTTATCTTAGTGTGTTGTTGGTCCATTGTTTAATAG
AAAATTAGTAGAGGAGTTTGAATTTACCTTACAGCATAAACCAGATAGAAAATAACGCATTCATCCAGTCATGCATCCAATGATTACCAA
GGCAGAAGGCCAAACACCACATAATTTGTGTCACTTGACAAAAGCAGTAATGTTAAAAGGCATTTTTTTCCTCATAGAGGTTTCTTGGCA
TACTTTCTTCAGACATACACTGTTTGGGCTTGAGTTTTGACTCATTATTTGCTGATGAAGCTACTTTAATCTGTTTGTGCCTTGGTATCT
TCGCTTTAAAATGTAATAATAGTTACCACTTTATGGATATACTGGGAAACTTAACTGAGTTAATACTTACAAGATGCTTAGAACAGTCTG
ACAATTTTTAACTCAACGAATGTTATTATTTGTTGCTATTATTGACAGCGTATGTTCTTAAAACTGCCAAAAATTGATTTAATTATATAG
AAACTTATGTAACTATTATCTTATATAATACTTAAGTATCATAAGTATGATAGAGTTATGCTTTTCTGGGTGTTTGAAAAATGTCAACTA
AGACAGATGGTGTCTCACTTATTTCTTGGTTATTTAATATTGTTCAGTTAGATGAAAGTGTGATTGTAGATTTGAAATACAAAATAAAAC
TTGGATACTGTGATTTTTTTAACATGGCCAGACTGTCATGTATTATAATGACATATACTTTTGTCCATAAAATGAAATTAAGTTTCACTG
AAAAATTTACATACTTTCCCCTGGGGATTCTATTGCTTCAGATTAAAGTTTATAAAGTATCATTAGTGTCTTCCACAGGGTCATTTTACA
CAAACACAGTTTTAGTGAGATGTCAACTGGCTTTTGTTGGTTGTTGGATTGACTGTGATTTAAAATGTTAAAGATGATATAATGCATCTT
GTTCTGCTTCTAGGCTGAAAGGTCACTGAGGCAGAGCTGTTTGTACCTTGTATCCCCTGGAATTTTGCCTAAACATTTGTGTACTCATAG

>99398_99398_1_WRN-ADAM9_WRN_chr8_30982516_ENST00000298139_ADAM9_chr8_38871484_ENST00000466936_length(amino acids)=1004AA_BP=940
MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYN
RGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL
VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPH
AFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE
DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLK
HLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL
KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTD
IKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL
RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRF
VRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME
KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRDLLPEDFVVYTYNKEGTLITDHPNIQRCGPLCIREQSTPGDRAGQNTQ

--------------------------------------------------------------
>99398_99398_2_WRN-ADAM9_WRN_chr8_30982516_ENST00000298139_ADAM9_chr8_38871484_ENST00000487273_length(transcript)=6581nt_BP=3074nt
GGAGCTGATGTGTACTGTGTGCGCCGGGGAGGCGCCGGCTTGTACTCGGCAGCGCGGGAATAAAGTTTGCTGATTTGGTGTCTAGCCTGG
ATGCCTGGGTTGCAGGCCCTGCTTGTGGTGGCGCTCCACAGTCATCCGGCTGAAGAAGACCTGTTGGACTGGATCTTCTCGGGTTTTCTT
TCAGATATTGTTTTGTATTTACCCATGAAGACATTGTTTTTTGGACTCTGCAAATAGGACATTTCAAAGATGAGTGAAAAAAAATTGGAA
ACAACTGCACAGCAGCGGAAATGTCCTGAATGGATGAATGTGCAGAATAAAAGATGTGCTGTAGAAGAAAGAAAGGCATGTGTTCGGAAG
AGTGTTTTTGAAGATGACCTCCCCTTCTTAGAATTCACTGGATCCATTGTGTATAGTTACGATGCTAGTGATTGCTCTTTCCTGTCAGAA
GATATTAGCATGAGTCTATCAGATGGGGATGTGGTGGGATTTGACATGGAGTGGCCACCATTATACAATAGAGGGAAACTTGGCAAAGTT
GCACTAATTCAGTTGTGTGTTTCTGAGAGCAAATGTTACTTGTTCCACGTTTCTTCCATGTCAGTTTTTCCCCAGGGATTAAAAATGTTG
CTTGAAAATAAAGCAGTTAAAAAGGCAGGTGTAGGAATTGAAGGAGATCAGTGGAAACTTCTACGTGACTTTGATATCAAATTGAAGAAT
TTTGTGGAGTTGACAGATGTTGCCAATAAAAAGCTGAAATGCACAGAGACCTGGAGCCTTAACAGTCTGGTTAAACACCTCTTAGGTAAA
CAGCTCCTGAAAGACAAGTCTATCCGCTGTAGCAATTGGAGTAAATTTCCTCTCACTGAGGACCAGAAACTGTATGCAGCCACTGATGCT
TATGCTGGTTTTATTATTTACCGAAATTTAGAGATTTTGGATGATACTGTGCAAAGGTTTGCTATAAATAAAGAGGAAGAAATCCTACTT
AGCGACATGAACAAACAGTTGACTTCAATCTCTGAGGAAGTGATGGATCTGGCTAAGCATCTTCCTCATGCTTTCAGTAAATTGGAAAAC
CCACGGAGGGTTTCTATCTTACTAAAGGATATTTCAGAAAATCTATATTCACTGAGGAGGATGATAATTGGGTCTACTAACATTGAGACT
GAACTGAGGCCCAGCAATAATTTAAACTTATTATCCTTTGAAGATTCAACTACTGGGGGAGTACAACAGAAACAAATTAGAGAACATGAA
GTTTTAATTCACGTTGAAGATGAAACATGGGACCCAACACTTGATCATTTAGCTAAACATGATGGAGAAGATGTACTTGGAAATAAAGTG
GAACGAAAAGAAGATGGATTTGAAGATGGAGTAGAAGACAACAAATTGAAAGAGAATATGGAAAGAGCTTGTTTGATGTCGTTAGATATT
ACAGAACATGAACTCCAAATTTTGGAACAGCAGTCTCAGGAAGAATATCTTAGTGATATTGCTTATAAATCTACTGAGCATTTATCTCCC
AATGATAATGAAAACGATACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGCATTTATCTCCCAATGATAAT
GAAAACGATACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGTCTTTAGAAAACCTCAATAGTGGCACGGTA
GAACCAACTCATTCTAAATGCTTAAAAATGGAAAGAAATCTGGGTCTTCCTACTAAAGAAGAAGAAGAAGATGATGAAAATGAAGCTAAT
GAAGGGGAAGAAGATGATGATAAGGACTTTTTGTGGCCAGCACCCAATGAAGAGCAAGTTACTTGCCTCAAGATGTACTTTGGCCATTCC
AGTTTTAAACCAGTTCAGTGGAAAGTGATTCATTCAGTATTAGAAGAAAGAAGAGATAATGTTGCTGTCATGGCAACTGGATATGGAAAG
AGTTTGTGCTTCCAGTATCCACCTGTTTATGTAGGCAAGATTGGCCTTGTTATCTCTCCCCTTATTTCTCTGATGGAAGACCAAGTGCTA
CAGCTTAAAATGTCCAACATCCCAGCTTGCTTCCTTGGATCAGCACAGTCAGAAAATGTTCTAACAGATATTAAATTAGGTAAATACCGG
ATTGTATACGTAACTCCAGAATACTGTTCAGGTAACATGGGCCTGCTCCAGCAACTTGAGGCTGATATTGGTATCACGCTCATTGCTGTG
GATGAGGCTCACTGTATTTCTGAGTGGGGGCATGATTTTAGGGATTCATTCAGGAAGTTGGGCTCCCTAAAGACAGCACTGCCAATGGTT
CCAATCGTTGCACTTACTGCTACTGCAAGTTCTTCAATCCGGGAAGACATTGTACGTTGCTTAAATCTGAGAAATCCTCAGATCACCTGT
ACTGGTTTTGATCGACCAAACCTGTATTTAGAAGTTAGGCGAAAAACAGGGAATATCCTTCAGGATCTGCAGCCATTTCTTGTCAAAACA
AGTTCCCACTGGGAATTTGAAGGTCCAACAATCATCTACTGTCCTTCTAGAAAAATGACACAACAAGTTACAGGTGAACTTAGGAAACTG
AATCTATCCTGTGGAACATACCATGCGGGCATGAGTTTTAGCACAAGGAAAGACATTCATCATAGGTTTGTAAGAGATGAAATTCAGTGT
GTCATAGCTACCATAGCTTTTGGAATGGGCATTAATAAAGCTGACATTCGCCAAGTCATTCATTACGGTGCTCCTAAGGACATGGAATCA
TATTATCAGGAGATTGGTAGAGCTGGTCGTGATGGACTTCAAAGTTCTTGTCACGTCCTCTGGGCTCCTGCAGACATTAACTTAAATAGG
CACCTTCTTACTGAGATACGTAATGAGAAGTTTCGATTATACAAATTAAAGATGATGGCAAAGATGGAAAAATATCTTCATTCTAGCAGA
TGTAGGAGACAAATCATCTTGTCTCATTTTGAGGACAAACAAGTACAAAAAGCCTCCTTGGGAATTATGGGAACTGAAAAATGCTGTGAT
AATTGCAGGTCCAGAGACCTTTTGCCTGAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATA
CAGAATCATTGTCATTATCGGGGCTATGTGGAGGGAGTTCATAATTCATCCATTGCTCTTAGCGACTGTTTTGGACTCAGAGGATTGCTG
CATTTAGAGAATGCGAGTTATGGGATTGAACCCCTGCAGAACAGCTCTCATTTTGAGCACATCATTTATCGAATGGATGATGTCTACAAA
GAGCCTCTGAAATGTGGAGTTTCCAACAAGGATATAGAGAAAGAAACTGCAAAGGATGAAGAGGAAGAGCCTCCCAGCATGACTCAGCTA
CTTCGAAGAAGAAGAGCTGTCTTGCCACAGACCCGGTATGTGGAGCTGTTCATTGTCGTAGACAAGGAAAGGTATGACATGATGGGAAGA
AATCAGACTGCTGTGAGAGAAGAGATGATTCTCCTGGCAAACTACTTGGATAGTATGTATATTATGTTAAATATTCGAATTGTGCTAGTT
GGACTGGAGATTTGGACCAATGGAAACCTGATCAACATAGTTGGGGGTGCTGGTGATGTGCTGGGGAACTTCGTGCAGTGGCGGGAAAAG
TTTCTTATCACACGTCGGAGACATGACAGTGCACAGCTAGTTCTAAAGAAAGGTTTTGGTGGAACTGCAGGAATGGCATTTGTGGGAACA
GTGTGTTCAAGGAGCCACGCAGGCGGGATTAATGTGTTTGGACAAATCACTGTGGAGACATTTGCTTCCATTGTTGCTCATGAATTGGGT
CATAATCTTGGAATGAATCACGATGATGGGAGAGATTGTTCCTGTGGAGCAAAGAGCTGCATCATGAATTCAGGAGCATCGGGTTCCAGA
AACTTTAGCAGTTGCAGTGCAGAGGACTTTGAGAAGTTAACTTTAAATAAAGGAGGAAACTGCCTTCTTAATATTCCAAAGCCTGATGAA
GCCTATAGTGCTCCCTCCTGTGGTAATAAGTTGGTGGACGCTGGGGAAGAGTGTGACTGTGGTACTCCAAAGGAATGTGAATTGGACCCT
TGCTGCGAAGGAAGTACCTGTAAGCTTAAATCATTTGCTGAGTGTGCATATGGTGACTGTTGTAAAGACTGTCGGTTCCTTCCAGGAGGT
ACTTTATGCCGAGGAAAAACCAGTGAGTGTGATGTTCCAGAGTACTGCAATGGTTCTTCTCAGTTCTGTCAGCCAGATGTTTTTATTCAG
AATGGATATCCTTGCCAGAATAACAAAGCCTATTGCTACAACGGCATGTGCCAGTATTATGATGCTCAATGTCAAGTCATCTTTGGCTCA
AAAGCCAAGGCTGCCCCCAAAGATTGTTTCATTGAAGTGAATTCTAAAGGTGACAGATTTGGCAATTGTGGTTTCTCTGGCAATGAATAC
AAGAAGTGTGCCACTGGGAATGCTTTGTGTGGAAAGCTTCAGTGTGAGAATGTACAAGAGATACCTGTATTTGGAATTGTGCCTGCTATT
ATTCAAACGCCTAGTCGAGGCACCAAATGTTGGGGTGTGGATTTCCAGCTAGGATCAGATGTTCCAGATCCTGGGATGGTTAACGAAGGC
ACAAAATGTGGTGCTGGAAAGATCTGTAGAAACTTCCAGTGTGTAGATGCTTCTGTTCTGAATTATGACTGTGATGTTCAGAAAAAGTGT
CATGGACATGGGGTATGTAATAGCAATAAGAATTGTCACTGTGAAAATGGCTGGGCTCCCCCAAATTGTGAGACTAAAGGATACGGAGGA
AGTGTGGACAGTGGACCTACATACAATGAAATGAATACTGCATTGAGGGACGGACTTCTGGTCTTCTTCTTCCTAATTGTTCCCCTTATT
GTCTGTGCTATTTTTATCTTCATCAAGAGGGATCAACTGTGGAGAAGCTACTTCAGAAAGAAGAGATCACAAACATATGAGTCAGATGGC
AAAAATCAAGCAAACCCTTCTAGACAGCCGGGGAGTGTTCCTCGACATGTTTCTCCAGTGACACCTCCCAGAGAAGTTCCTATATATGCA
AACAGATTTGCAGTACCAACCTATGCAGCCAAGCAACCTCAGCAGTTCCCATCAAGGCCACCTCCACCACAACCGAAAGTATCATCTCAG
GGAAACTTAATTCCTGCCCGTCCTGCTCCTGCACCTCCTTTATATAGTTCCCTCACTTGATTTTTTTAACCTTCTTTTTGCAAATGTCTT
CAGGGAACTGAGCTAATACTTTTTTTTTTTCTTGATGTTTTCTTGAAAAGCCTTTCTGTTGCAACTATGAATGAAAACAAAACACCACAA
AACAGACTTCACTAACACAGAAAAACAGAAACTGAGTGTGAGAGTTGTGAAATACAAGGAAATGCAGTAAAGCCAGGGAATTTACAATAA
CATTTCCGTTTCCATCATTGAATAAGTCTTATTCAGTCATCGGTGAGGTTAATGCACTAATCATGGATTTTTTGAACATGTTATTGCAGT
GATTCTCAAATTAACTGTATTGGTGTAAGAGTTTTGTCATTAAGTGTTTAAGTGTTATTCTGAATTTTCTACCTTAGTTATCATTAATGT
AGTTCCTCATTGAACATGTGATAATCTAATACCTGTGAAAACTGACTAATCAGCTGCCAATAATATCTAATATTTTTCATCATGCACGAA
TTAATAATCATCATACTCTAGAATCTTGTCTGTCACTCACTACATGAATAAGCAAATATTGTCTTCAAAAGAATGCACAAGAACCACAAT
TAAGATGTCATATTATTTTGAAAGTACAAAATATACTAAAAGAGTGTGTGTGTATTCACGCAGTTACTCGCTTCCATTTTTATGACCTTT
CAACTATAGGTAATAACTCTTAGAGAAATTAATTTAATATTAGAATTTCTATTATGAATCATGTGAAAGCATGACATTCGTTCACAATAG
CACTATTTTAAATAAATTATAAGCTTTAAGGTACGAAGTATTTAATAGATCTAATCAAATATGTTGATTCATGGCTATAATAAAGCAGGA
GCAATTATAAAATCTTCAATCAATTGAACTTTTACAAAACCACTTGAGAATTTCATGAGCACTTTAAAATCTGAACTTTCAAAGCTTGCT
ATTAAATCATTTAGAATGTTTACATTTACTAAGGTGTGCTGGGTCATGTAAAATATTAGACACTAATATTTTCATAGAAATTAGGCTGGA
GAAAGAAGGAAGAAATGGTTTTCTTAAATACCTACAAAAAAGTTACTGTGGTATCTATGAGTTATCATCTTAGCTGTGTTAAAAATGAAT
TTTTACTATGGCAGATATGGTATGGATCGTAAAATTTTAAGCACTAAAAATTTTTTCATAACCTTTCATAATAAAGTTTAATAATAGGTT
TATTAACTGAATTTCATTAGTTTTTTAAAAGTGTTTTTGGTTTGTGTATATATACATATACAAATACAACATTTACAATAAATAAAATAC

>99398_99398_2_WRN-ADAM9_WRN_chr8_30982516_ENST00000298139_ADAM9_chr8_38871484_ENST00000487273_length(amino acids)=1676AA_BP=940
MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYN
RGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL
VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPH
AFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE
DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLK
HLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL
KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTD
IKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL
RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRF
VRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME
KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDC
FGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKE
RYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTA
GMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLL
NIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFC
QPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPV
FGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNC
ETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPP

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Fusion Gene PPI Analysis for WRN-ADAM9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	WRN	chr8:30982516	chr8:38871484	ENST00000298139	+	23	35	2_277	941.6666666666666	1433.0	WRNIP1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	WRN	chr8:30982516	chr8:38871484	ENST00000298139	+	23	35	987_993	941.6666666666666	1433.0	DNA

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for WRN-ADAM9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for WRN-ADAM9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source