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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WWC3-SHROOM2 (FusionGDB2 ID:99471)

Fusion Gene Summary for WWC3-SHROOM2

check button Fusion gene summary
Fusion gene informationFusion gene name: WWC3-SHROOM2
Fusion gene ID: 99471
HgeneTgene
Gene symbol

WWC3

SHROOM2

Gene ID

55841

357

Gene nameWWC family member 3shroom family member 2
SynonymsBM042APXL|HSAPXL
Cytomap

Xp22.2

Xp22.2

Type of geneprotein-codingprotein-coding
Descriptionprotein WWC3protein Shroom2APX homolog of Xenopusapical-like protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000380861, ENST00000454666, 
ENST00000466248, 		ENST00000418909, 
ENST00000493668, ENST00000380913, 
Fusion gene scores* DoF score4 X 4 X 2=326 X 5 X 5=150
# samples 48
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WWC3 [Title/Abstract] AND SHROOM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSHROOM2(9912953)-WWC3(10031485), # samples:1
WWC3(10102636)-SHROOM2(9841692), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWC3

GO:0000122

negative regulation of transcription by RNA polymerase II

24682284

HgeneWWC3

GO:0035331

negative regulation of hippo signaling

24682284

TgeneSHROOM2

GO:0000902

cell morphogenesis

16684770


check buttonFusion gene breakpoints across WWC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SHROOM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-4357-01AWWC3chrX

10102636

-SHROOM2chrX

9841692

+


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Fusion Gene ORF analysis for WWC3-SHROOM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000380861ENST00000418909WWC3chrX

10102636

-SHROOM2chrX

9841692

+
5CDS-intronENST00000380861ENST00000493668WWC3chrX

10102636

-SHROOM2chrX

9841692

+
5CDS-intronENST00000454666ENST00000418909WWC3chrX

10102636

-SHROOM2chrX

9841692

+
5CDS-intronENST00000454666ENST00000493668WWC3chrX

10102636

-SHROOM2chrX

9841692

+
In-frameENST00000380861ENST00000380913WWC3chrX

10102636

-SHROOM2chrX

9841692

+
In-frameENST00000454666ENST00000380913WWC3chrX

10102636

-SHROOM2chrX

9841692

+
intron-3CDSENST00000466248ENST00000380913WWC3chrX

10102636

-SHROOM2chrX

9841692

+
intron-intronENST00000466248ENST00000418909WWC3chrX

10102636

-SHROOM2chrX

9841692

+
intron-intronENST00000466248ENST00000493668WWC3chrX

10102636

-SHROOM2chrX

9841692

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380861WWC3chrX10102636-ENST00000380913SHROOM2chrX9841692+1034631542278392605
ENST00000454666WWC3chrX10102636-ENST00000380913SHROOM2chrX9841692+1003528438075282482

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380861ENST00000380913WWC3chrX10102636-SHROOM2chrX9841692+0.0020972050.99790275
ENST00000454666ENST00000380913WWC3chrX10102636-SHROOM2chrX9841692+0.0014639610.998536

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Fusion Genomic Features for WWC3-SHROOM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WWC3-SHROOM2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:9912953/chrX:10031485)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWC3chrX:10102636chrX:9841692ENST00000380861-1923230_3449211093.0Coiled coilOntology_term=ECO:0000255
HgeneWWC3chrX:10102636chrX:9841692ENST00000380861-192340_1269211093.0Coiled coilOntology_term=ECO:0000255
HgeneWWC3chrX:10102636chrX:9841692ENST00000380861-1923761_8129211093.0Coiled coilOntology_term=ECO:0000255
HgeneWWC3chrX:10102636chrX:9841692ENST00000454666-1822230_3449211093.0Coiled coilOntology_term=ECO:0000255
HgeneWWC3chrX:10102636chrX:9841692ENST00000454666-182240_1269211093.0Coiled coilOntology_term=ECO:0000255
HgeneWWC3chrX:10102636chrX:9841692ENST00000454666-1822761_8129211093.0Coiled coilOntology_term=ECO:0000255
HgeneWWC3chrX:10102636chrX:9841692ENST00000380861-1923347_4669211093.0Compositional biasNote=Ser-rich
HgeneWWC3chrX:10102636chrX:9841692ENST00000454666-1822347_4669211093.0Compositional biasNote=Ser-rich
HgeneWWC3chrX:10102636chrX:9841692ENST00000380861-1923598_7239211093.0DomainC2
HgeneWWC3chrX:10102636chrX:9841692ENST00000454666-1822598_7239211093.0DomainC2
TgeneSHROOM2chrX:10102636chrX:9841692ENST000003809130101065_1068551617.0Compositional biasNote=Poly-Pro
TgeneSHROOM2chrX:10102636chrX:9841692ENST00000380913010150_153551617.0Compositional biasNote=Poly-Ser
TgeneSHROOM2chrX:10102636chrX:9841692ENST00000380913010314_320551617.0Compositional biasNote=Poly-Pro
TgeneSHROOM2chrX:10102636chrX:9841692ENST00000380913010343_346551617.0Compositional biasNote=Poly-Ala
TgeneSHROOM2chrX:10102636chrX:9841692ENST000003809130101317_1611551617.0DomainASD2
TgeneSHROOM2chrX:10102636chrX:9841692ENST00000380913010684_773551617.0DomainASD1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWC3chrX:10102636chrX:9841692ENST00000380861-1923967_10369211093.0Coiled coilOntology_term=ECO:0000255
HgeneWWC3chrX:10102636chrX:9841692ENST00000454666-1822967_10369211093.0Coiled coilOntology_term=ECO:0000255
TgeneSHROOM2chrX:10102636chrX:9841692ENST0000038091301026_108551617.0DomainPDZ


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Fusion Gene Sequence for WWC3-SHROOM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99471_99471_1_WWC3-SHROOM2_WWC3_chrX_10102636_ENST00000380861_SHROOM2_chrX_9841692_ENST00000380913_length(transcript)=10346nt_BP=3154nt
GCGGGGCCCGCGCCGTCATGCCTTGGCTGAGCGGCGGCCGGCGGCGACGGCGGGGACAGCCGCGCGAGGCCCCGCGGGAGCCGCCGCCTT
CTGCGCAGCCCCAGCGGGAACCGCGCCGCCGGCGCCCCCCGCCGCGGTCCCCACGCCCCCAGCTCCTTCCGCGCCGCCGCCGCGGGCCCG
GGAGAGCGCCGAGCTGCCGCTGCCCGCCGGCTGGGAGGAGGCGCGAGACTACGACGGTCGCGTCTTTTACATTGACCACAACACGCGCCA
GACGTCGTGGATCGACCCCCGCGACCGGATAACAAAGCCATTGACCTTTGCCGATTGTGTTGGGGACGAACTTCCTTTAGGATGGGAAAC
CGTATATGATAAACAAATTGGAGTTTATTACATGGACCACATAAATAAACTTACCCAGATTGAGGATCCAAGAGAACAGTGGAGGCGAGA
GCAAGAGCGCATGTTGAAGGAATATTTAATTGTAGCTCAGGAGGCTCTCAATGCCAAGAAAGAAATCTACCAGATTAAGCAGCAGCGGTT
CGAGCTGGCCCAGGAGGAATACCAGCAGCTGCACAAAATGTGTGAGGATGACAGCCGCTCGTACGCCAGCTCATTCTCTGGATATTCAAC
AAATACAAAGTATGACCCACACCAAATTAAAGCAGAAATAGCAAGTCGTCGGGATAGGCTTTCCAGATTAAAACGAGAGCTGACCCAGAT
GAAGCAGGAACTGCAGTACAAAGAAAAGGGGGTGGAGACCCTGCAAGAGATTGATCGGAAGATGTCAAGTACTCACACCAGCTACAAACT
GGATGAGGCGCAGGCTATCATGAGTGAGCTCCGGACCATCAAGAAGGCCATTTGCACAGGCGAGAAGGAGAGGCGGGACCTGATGCATAG
CCTGGCCAAGCTGACCGATAGCTTCAAGAACAGCTGCTCCGTTACCGACTCTCTAGTGGACTTCCCTCACCATGTAGGCGTGCCTGGCGA
TGCTGGTGTACCCCAGCAGTTCTGCGATGCCGGCTCCCAGACTGATATCATCGGGGAGTTTGTCTTTGATGATAAAACAAGACTTGTAGA
CCGAGTCAGACTTAATTGGCAATATGAAGAAGCCAGAAAGAGAGTCGCCAACATCCAGCAGCAGCTGGCCCGGCTTGACAATGAGTCCTG
GCCAAGCACGGCCGAGGCTGACAGGGACCGGCTGCAGCTCATCAAGGAGAAGGAGGCCCTGCTGCAGGAGCTTCAGCTCATCATTGCACA
GCGCCGCTCTGCGGGAGATGTGGCCCGGCTGGAGGAGGAGCGGGAGCGCCTAGAGGAGGAGCTGCGGCGTGCACGGGCCACCTCCGCACA
GGGCGCCACGGAGAGGATTCTGCTTCAGGAAAAAAGGAATTGTCTACTTATGCAGCTGGAAGAAGCCACCCGCTTAACATCCTACCTCCA
GTCCCAGTTAAAAAGCCTGTGTGCCAGCACCCTGACGGTGTCCTCGGGGAGCAGCCGCGGGTCCCTAGCCTCCAGCCGTGGGTCTCTGGC
CTCCAGCCGGGGCTCCCTGAGCTCGGTCAGCTTCACGGACATCTACGGCCTCCCGCAGTACGAGAAGCCCGACGCTGAGGGCAGCCAGCT
TCTACGCTTCGACCTCATTCCCTTCGACTCTCTGGGGCGAGATGCTCCCTTTTCAGAGCCCCCAGGCCCCTCGGGCTTCCACAAGCAGAG
GCGGTCCCTGGACACGCCCCAGTCCCTGGCATCGCTGTCCTCCCGCTCCTCGCTGTCCTCGCTGTCGCCCCCAAGCTCGCCCCTGGACAC
GCCCTTCCTCCCTGCCTCACGGGACTCGCCGCTGGCGCAGCTGGCGGACAGCTGTGAGGGGCCAGGCCTGGGCGCCCTAGACAGACTGCG
GGCACACGCCTCGGCTATGGGGGACGAAGACTTACCAGGCATGGCGGCCCTTCAGCCACACGGGGTCCCCGGGGATGGGGAAGGGCCGCA
CGAGCGAGGACCCCCACCAGCCAGCGCTCCCGTGGGTGGAACAGTGACTCTTCGAGAAGACAGTGCCAAGAGGTTGGAGAGGAGGGCACG
CCGCATCTCCGCATGTCTGTCGGATTATTCGCTAGCCAGCGACAGTGGGGTGTTTGAACCTCTAACCAAAAGGAACGAAGATGCCGAGGA
GCCTGCCTACGGAGACACGGCCAGTAACGGAGATCCCCAGATCCACGTGGGACTCCTGCGCGACAGTGGCAGCGAGTGTCTCCTCGTGCA
CGTGCTGCAGCTGAAGAACCCGGCGGGGCTGGCGGTGAAGGAAGACTGCAAAGTCCACATCCGAGTCTATTTGCCCCCACTGGACTCGGG
CACGCCCAACACTTACTGCTCCAAGGCTCTGGAGTTCCAAGTGCCGCTGGTGTTTAACGAAGTGTTCAGAATCCCCGTGCATTCCAGCGC
GTTGACACTGAAGTCACTTCAGTTATACGTGTGTTCAGTGACTCCGCAGCTGCAGGAAGAACTGCTGGGCATTGCTCAGATTAACCTGGC
TGACTATGACAGTTTGAGTGAGATGCAGCTGCGCTGGCATTCCGTGCAGGTGTTCACCAGCTCTGAACCATCAAGGACGCGGGAGGCTGG
GTGTGCAGGAGAGAGCTCCGCCCGGGACCCTGCACACACCATCTCCATCTCCGGCAAGACGGATGCGGTGACGGTGCTCCTGGCCAGAAC
CACGGCACAGCTGCAGGCGGTGGAGAGGGAACTGGCCGAGGAGCGGGCCAAGCTGGAGTACACGGAGGAGGAGGTCCTGGAGATGGAGCG
CAAGGAGGAGCAGGCCGAGGCCATATCCGAGCGGAGTTGGCAAGCGGACTCGGTGGATAGCGGCTGTAGCAACTGCACCCAGACCAGCCC
TCCGTACCCAGAGCCCTGTTGCATGGGTATCGACTCCATCCTGGGCCACCCATTTGCTGCTCAGGCAGGGCCTTACAGCCCCGAGAAATT
TCAGCCCTCGCCTCTTAAGGTTGATAAGGAAACCAACACGGAAGATCTCTTTCTGGAAGAAGCAGCCAGCCTCGTGAAGGAGCGGCCCAG
CCGCCGGGCCCGAGGGTCGCCTTTTGTTCGGAGTGGCACGATTGTCCGTTCCCAGACATTCTCGCCTGGAGCACGAAGCCAGTATGTTTG
CAGAATTGAAGAGGGCAGTAAAGCCGCGGCGGTCGACAAGTTACTGGCTGGAGATGAGATCGTCGGCATCAATGACATTGGTCTCTCAGG
GTTTAGACAGGAAGCGATTTGCCTGGTGAAGGGGTCCCATAAGACCCTGAAGCTGGTCGTCAAAAGGAGGAGCGAGCTGGGCTGGAGGCC
TCACTCCTGGCATGCCACCAAGTTCTCTGACAGCCACCCCGAGCTAGCGGCCTCCCCATTCACCTCCACCAGCGGCTGTCCTTCCTGGTC
CGGCCGACACCACGCGAGTTCTTCCTCCCACGACCTGTCCAGTTCCTGGGAGCAGACGAACCTACAGCGCACCTTAGATCACTTCAGCTC
CTTGGGGAGCGTTGACAGCCTGGACCACCCCTCCAGTCGCCTCTCGGTGGCCAAGTCCAACAGCAGCATCGACCACCTGGGCAGCCACAG
CAAGCGCGACTCGGCCTACGGCTCCTTCTCCACCAGCTCTAGCACTCCTGACCACACCTTGTCCAAAGCCGACACGTCCTCCGCAGAGAA
CATCCTCTACACTGTGGGCCTCTGGGAGGCTCCCAGGCAGGGTGGCCGGCAGGCCCAGGCCGCAGGCGACCCTCAGGGCTCGGAGGAGAA
GCTCAGTTGTTTCCCGCCCAGGGTCCCCGGTGACAGCGGCAAAGGCCCCAGGCCAGAGTACAATGCCGAGCCCAAGCTGGCTGCCCCTGG
GAGGTCCAATTTTGGGCCAGTCTGGTATGTTCCCGATAAGAAGAAAGCACCATCATCCCCACCTCCTCCCCCTCCCCCTCTCCGCAGTGA
CAGCTTTGCTGCCACCAAGAGCCACGAGAAGGCCCAGGGCCCTGTGTTCTCAGAGGCGGCTGCGGCACAGCACTTTACGGCCCTGGCCCA
GGCTCAGCCTCGTGGTGACCGGAGACCAGAGCTCACCGATCGGCCTTGGAGGTCAGCACACCCGGGGAGCCTCGGGAAGGGATCGGGAGG
CCCGGGCTGCCCACAGGAGGCCCACGCAGACGGCAGCTGGCCGCCCTCCAAGGATGGAGCTTCCAGTAGGCTGCAGGCCTCTCTGTCCAG
CTCAGATGTGCGCTTCCCTCAGTCTCCTCATAGCGGCCGACACCCTCCCCTATACAGCGACCACAGCCCCCTCTGTGCTGACAGCCTTGG
GCAGGAGCCAGGGGCTGCCAGCTTCCAGAACGACAGCCCTCCTCAGGTGAGGGGGCTCAGCAGCTGTGACCAGAAGCTGGGGAGCGGCTG
GCAGGGTCCCCGGCCCTGTGTGCAGGGAGACCTGCAAGCAGCACAGCTCTGGGCGGGATGCTGGCCTTCTGACACAGCCCTTGGAGCCCT
CGAGAGTCTTCCCCCACCCACGGTGGGCCAGAGCCCACGCCATCACCTACCTCAGCCTGAGGGTCCTCCGGATGCCCGCGAGACAGGACG
GTGTTACCCGCTGGACAAAGGGGCCGAGGGCTGCTCCGCGGGAGCCCAGGAGCCTCCCAGGGCCAGCCGTGCAGAAAAAGCCAGCCAGAG
GCTGGCAGCCAGCATCACGTGGGCAGATGGGGAGAGCAGCAGGATCTGCCCGCAGGAGACGCCCCTGTTGCACTCCCTGACCCAGGAGGG
GAAGCGCCGGCCTGAGAGCAGTCCAGAGGACAGCGCCACCAGACCGCCACCGTTCGACGCCCACGTGGGCAAGCCCACCCGAAGAAGCGA
CCGCTTTGCCACCACCCTGCGGAATGAGATCCAGATGCATAGAGCCAAGCTGCAGAAGAGCCGGAGCACAGTGGCTCTGACTGCAGCAGG
GGAGGCGGAGGATGGCACCGGCCGCTGGAGGGCCGGGTTGGGAGGTGGCACCCAGGAAGGACCCCTCGCTGGCACCTATAAAGACCACCT
GAAAGAGGCCCAAGCCCGGGTCCTGAGGGCCACGTCCTTCAAGCGCCGCGACTTGGACCCCAACCCAGGAGACCTATACCCGGAGTCACT
GGAACACCGGATGGGGGATCCAGACACTGTCCCCCACTTCTGGGAGGCAGGCCTGGCCCAGCCACCCTCATCTACAAGTGGCGGGCCCCA
CCCGCCCCGCATCGGAGGCCGGAGACGGTTCACAGCTGAGCAGAAATTGAAGTCCTACTCGGAACCTGAGAAGATGAACGAGGTGGGCCT
CACGAGGGGCTACAGTCCTCACCAGCACCCCAGGACATCTGAGGATACTGTGGGCACGTTTGCTGACAGGTGGAAGTTTTTTGAGGAAAC
GAGCAAACCTGTTCCCCAGAGGCCTGCCCAGAAGCAAGCTCTTCACGGAATCCCGAGAGACAAGCCAGAGAGGCCGCGGACAGCGGGCCG
CACATGTGAGGGCACGGAGCCCTGGTCGCGCACCACCTCCCTTGGGGACAGCCTCAACGCTCACAGCGCAGCGGAGAAGGCAGGGACTTC
AGACCTGCCGCGGAGGCTCGGCACCTTTGCAGAGTATCAGGCCTCTTGGAAGGAACAGAGGAAACCTCTGGAGGCCAGGAGCTCTGGGCG
CTGCCACTCAGCGGATGACATCCTGGATGTGAGCCTGGACCCACAGGAGAGGCCGCAGCACGTTCATGGGAGGTCCCGGTCTTCACCGTC
CACAGACCACTACAAGCAGGAAGCTTCTGTCGAACTGCGAAGGCAGGCAGGGGACCCCGGCGAGCCCAGAGAAGAGCTTCCCTCCGCAGT
CCGGGCCGAGGAGGGACAGTCCACGCCGAGACAAGCAGATGCCCAGTGTCGGGAAGGCAGCCCAGGATCACAGCAGCACCCACCGAGTCA
GAAGGCACCGAACCCACCCACATTCTCTGAACTATCTCACTGCCGGGGAGCCCCAGAGCTGCCCCGGGAGGGCCGGGGCCGAGCGGGAAC
CCTACCTCGAGATTATAGATACTCGGAGGAGAGCACCCCAGCAGACTTGGGACCCCGAGCCCAGAGCCCTGGCTCACCCCTGCATGCTCG
AGGACAAGACTCGTGGCCAGTGAGCTCAGCCCTGCTCTCCAAGAGGCCAGCCCCACAGAGGCCACCGCCACCCAAGCGCGAGCCCAGGAG
ATACAGGGCCACAGACGGCGCACCTGCTGACGCCCCCGTGGGCGTCCTCGGCAGGCCCTTCCCAACGCCATCCCCTGCGTCCCTGGATGT
GTATGTGGCCCGCCTGTCCCTCTCCCACAGCCCCTCTGTGTTCAGCAGTGCCCAGCCCCAGGACACCCCGAAGGCCACTGTCTGTGAGCG
TGGAAGCCAGCATGTGAGCGGGGACGCATCACGTCCTCTGCCAGAAGCACTGCTCCCTCCCAAGCAGCAGCACCTGCGCCTGCAGACGGC
CACCATGGAGACCTCGCGCTCCCCCTCGCCCCAGTTCGCCCCCCAGAAACTGACGGACAAACCTCCCCTGCTCATCCAGGATGAGGATTC
AACCAGAATTGAGCGGGTGATGGACAACAACACCACGGTGAAGATGGTGCCCATCAAGATCGTGCACTCGGAGAGCCAGCCAGAGAAGGA
GAGCCGCCAGAGCCTGGCATGCCCCGCCGAGCCACCTGCCCTGCCCCACGGGCTGGAGAAAGACCAGATCAAGACGCTGAGCACATCTGA
GCAGTTCTACTCGCGCTTCTGTCTGTACACGCGGCAGGGTGCTGAGCCCGAGGCCCCACATAGGGCCCAGCCGGCTGAGCCCCAGCCCCT
GGGCACCCAGGTGCCCCCCGAGAAAGACCGCTGCACCTCCCCTCCAGGGCTCAGCTACATGAAGGCCAAAGAGAAGACTGTGGAAGACCT
GAAGTCGGAGGAGCTGGCCAGGGAGATCGTGGGGAAGGATAAGTCCCTGGCCGACATCCTGGATCCCAGTGTGAAGATCAAAACCACTAT
GGACTTGATGGAAGGCATCTTCCCCAAAGACGAGCACCTCCTGGAAGAAGCCCAGCAACGGAGGAAGCTGCTCCCCAAAATCCCCTCTCC
TAGAAGCACAGAGGAGAGGAAAGAGGAGCCCAGCGTGCCTGCGGCCGTGTCCCTGGCCACCAATTCTACCTACTACAGCACGTCGGCCCC
CAAGGCGGAGCTGCTGATCAAGATGAAGGACCTGCAGGAGCAGCAGGAGCACGAAGAGGATTCGGGAAGCGACTTGGACCACGACCTGTC
GGTGAAGAAGCAGGAGCTCATCGAGAGCATCAGCCGCAAGCTGCAGGTGCTCCGGGAGGCCCGCGAGAGCCTGCTGGAGGACGTGCAGGC
CAACACCGTGCTGGGGGCCGAGGTGGAGGCCATCGTGAAAGGCGTCTGCAAGCCCAGCGAGTTTGACAAGTTCCGGATGTTCATTGGAGA
CCTGGACAAAGTGGTGAACCTCCTGCTGTCGCTGTCAGGCCGCCTGGCCCGGGTGGAGAATGCCCTCAATAATTTGGACGACGGCGCTTC
TCCCGGTGATCGGCAATCACTGCTTGAGAAGCAGAGAGTCCTGATCCAGCAGCACGAGGACGCCAAGGAGCTCAAGGAGAACCTGGACCG
CCGCGAGCGCATCGTCTTTGACATTTTGGCCAACTATCTGAGCGAGGAGAGCCTCGCGGACTATGAGCACTTCGTGAAGATGAAGTCGGC
CCTCATCATCGAGCAGCGGGAGCTGGAAGATAAAATCCACCTTGGTGAAGAGCAGCTGAAGTGCTTATTGGACAGCCTTCAGCCCGAAAG
GGGCAAATAAGAGACCAGTCCCCGGTGGAGGAGGGGCACGGGGCCTCCGAGCTCCAGCTCCGTTCCCAAGGATACTCGTGAAGACCCCAT
CTGTGTTCATGGCCTGGAAAGAGACTTCTCCCATAGCAAAGAGGCTGTTATAAAAGCAATAACTTTTGTGTTTGTGTGGGATGATTTATT
TAATTTTTTAGTTTCCCCTTTGATTGCTGAGAGCCATTTTCCTTTACACATAACTACACCTGACACCAGGCTCTGCTGGATGTGAGTTTC
CACTGCATGGGCTGTGGGCTGGGCCTGTGGTGCCTGCCGAGTGGTCACTGTCAGTGGGAAACCCGTTGTTCCTCCCGTCTTCAGATGCTG
AGCCAACTGCTTGGACAGCAGCCAGCGCGTCATGACGTGCATGAGAGGGGGACCCTGGTGCTCATCTTCTCTTGTCATTCATCCAGGCAT
GGGCTGCCAGGTTTTGTCCCTGCTCGTTCAACAGTGTGAGCATTTGTCTCTGTTATCTAATGATGTTCTCTGACCCAGCAGAAATCATCA
TCATGATGATGATAATTTATTAACTTTTTGGAAGGGTGAATAGTTTCCTAATGGTTAAAAACCAACTGTGAAAGGAACCACCTGTGTGGT
TGGGTTCACTCATTCTCAGATTAAATTGCCACTTAAAGAAATAACGTGCATGCTTTAAAAAACACAGTCACGCACCAAGCAGGCAAATAG
CTTTAGTCCTTCTCACCTCACATCACAGTTGTTCTGCAAAGTAAAATTTTTTGGTTAAGAGCGTGTCCAGTAGTAATGTGCTTGTTAGCT
GTTTCTCAAGACCAACAGAAGATTTTTTCAGTTACTTTCCCCCCATGTATTTTGTATGCATATGATTGTCCGTGATAATTGGCTACTTTT
CCATTGTTTCCTCCTTAAATCGTTTAGCATGGCATGAGGGCCACATTCCATGGACGGGAAGACCCCTTCCTCTTCAGAGGTCCCGTGGAC
TACACAGCTCCTGAGCTTGATCTTTTTCTGCCATGAAGTTTAAAGATTCTATGCCCATTTCCTTGATTGAAATGGCAGGATTCTAAAGAG
AGCCTGGTTTGTTAAAAGAAAACACTGTCATGCTGTCAGTTCCCAATTGACAAGTCACAGACTGGGAGAAAATATTTGCAAATCGTGTAT
CTGACAAAAGGTTTGTGTCCAGGATGTACAAAGAACTCTCAAACCGGATAGTAAGAAAACAAACAGCCCAAGTGAAAAGCAGGCAAAAGA
CTTGAATAGACACTTCACCAAAGAGCATACACGCGTGGCAAACAAGCACACGAAAAGACGTTCAGCCGCCGATGGCTTGGTTATAATTTA
TAACTTACTTATTTTTATCTAATAATTGTAGATTCAGTGTATTTCTTCAAAAAATGTTTAATTAAATGCATGTTAATGGTGAGTGAATCC
CTTGGGTGACTTCGTGTTTAGGTCGTATTAGGGCATTTGTTGGATCAACGGATCATTTTAACCCTGACTTCCCCTTATTCCCATAAAAGA
AGTTTTCCAGTGGAATGGAGATTTCATTTTGTCAGCAGCAGTGACCACAGCCTTACCAAAGCAGACGCGTGCGCGTGCACAGATGCACAC
ACACAGATGTCTTAAAAGACTAGAATCCACACTTCCTGAGCCAGAGGGGCCGTGTTGACGGTAATGCATTCTCTATAGAGCCAAGTCCAA
ACTGGCAAGCTCAATGATGCAGGCAATAAACCGCCTTTTTGGCAGCCTACCAATGCCAAAAGGATAAATGTCTTTCCAAAAGTGTGTATT
CCTGTTAAATTAAGCTCTTGCTAACTTGAAAAATCCCTGTTCTGCCAGCGAAGCTTCCTCCTCCTCTCCAGCTGGTAGTCACTTGCGTGA
ATGCTGGTCAGTCTGAAAAGGTGAAGCTGGCTGTGCACTTACCCCCATCTTTCTCCCTCGGGGAGACGACCCAAGGAATTTCAGAGTATT
TTGTTTGGCAGAGCTTTTACCTGTTATTCTTTGCCCTCAAATACAGTATTGTGGTCATTTTGATGATATGTGTGTAAAATGTGAATAATC
CAATTGGTGTCTGTACTCAGCCTTTTGATGTCTTTTTAGGACTTTCTCTTCTACACAGCAATACGTCGTGCTCGAGTATCCTTGTAGCAA
AGCACATAGAGCCAGCTGTCCTGTCAGTTCCCCTGTTTGCCTCTGAAACGTCTGGTTAGTGGGGACCCAAAGATTCTAGTGAGTCAACAT
CCATAACTCTGTATCTAGTTGTATTATTCATAGAAAATCAATCTGGTGCTAATGGTTGGCCCTGGTGTTGTTGGGTGGCAGCTGCTCCTT
CGCCCTCTTGTAGTGTGGCTGTGGAGGGCTCTGCCTATGGGGGGTGGCCTGTGGCTTGTATCCTTCAGTCCACCACAGCAAATGTGTGTA

>99471_99471_1_WWC3-SHROOM2_WWC3_chrX_10102636_ENST00000380861_SHROOM2_chrX_9841692_ENST00000380913_length(amino acids)=2605AA_BP=1044
MAERRPAATAGTAARGPAGAAAFCAAPAGTAPPAPPAAVPTPPAPSAPPPRARESAELPLPAGWEEARDYDGRVFYIDHNTRQTSWIDPR
DRITKPLTFADCVGDELPLGWETVYDKQIGVYYMDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEY
QQLHKMCEDDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRKMSSTHTSYKLDEAQAIM
SELRTIKKAICTGEKERRDLMHSLAKLTDSFKNSCSVTDSLVDFPHHVGVPGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRVRLNWQ
YEEARKRVANIQQQLARLDNESWPSTAEADRDRLQLIKEKEALLQELQLIIAQRRSAGDVARLEEERERLEEELRRARATSAQGATERIL
LQEKRNCLLMQLEEATRLTSYLQSQLKSLCASTLTVSSGSSRGSLASSRGSLASSRGSLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIP
FDSLGRDAPFSEPPGPSGFHKQRRSLDTPQSLASLSSRSSLSSLSPPSSPLDTPFLPASRDSPLAQLADSCEGPGLGALDRLRAHASAMG
DEDLPGMAALQPHGVPGDGEGPHERGPPPASAPVGGTVTLREDSAKRLERRARRISACLSDYSLASDSGVFEPLTKRNEDAEEPAYGDTA
SNGDPQIHVGLLRDSGSECLLVHVLQLKNPAGLAVKEDCKVHIRVYLPPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQ
LYVCSVTPQLQEELLGIAQINLADYDSLSEMQLRWHSVQVFTSSEPSRTREAGCAGESSARDPAHTISISGKTDAVTVLLARTTAQLQAV
ERELAEERAKLEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSNCTQTSPPYPEPCCMGIDSILGHPFAAQAGPYSPEKFQPSPLKV
DKETNTEDLFLEEAASLVKERPSRRARGSPFVRSGTIVRSQTFSPGARSQYVCRIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQEAIC
LVKGSHKTLKLVVKRRSELGWRPHSWHATKFSDSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDSL
DHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENILYTVGLWEAPRQGGRQAQAAGDPQGSEEKLSCFPPR
VPGDSGKGPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDR
RPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCADSLGQEPGAAS
FQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGDLQAAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDARETGRCYPLDKG
AEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSDRFATTLR
NEIQMHRAKLQKSRSTVALTAAGEAEDGTGRWRAGLGGGTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGDP
DTVPHFWEAGLAQPPSSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVGTFADRWKFFEETSKPVPQR
PAQKQALHGIPRDKPERPRTAGRTCEGTEPWSRTTSLGDSLNAHSAAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADDI
LDVSLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPT
FSELSHCRGAPELPREGRGRAGTLPRDYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGA
PADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRS
PSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFC
LYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIF
PKDEHLLEEAQQRRKLLPKIPSPRSTEERKEEPSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVKKQELI
ESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSL

--------------------------------------------------------------
>99471_99471_2_WWC3-SHROOM2_WWC3_chrX_10102636_ENST00000454666_SHROOM2_chrX_9841692_ENST00000380913_length(transcript)=10035nt_BP=2843nt
TGACCTTTGCCGATTGTGTTGGGGACGAACTTCCTTTAGGATGGGAAACCGTATATGATAAACAAATTGGAGTTTATTACATGGACCACA
TAAATAAACTTACCCAGATTGAGGATCCAAGAGAACAGTGGAGGCGAGAGCAAGAGCGCATGTTGAAGGAATATTTAATTGTAGCTCAGG
AGGCTCTCAATGCCAAGAAAGAAATCTACCAGATTAAGCAGCAGCGGTTCGAGCTGGCCCAGGAGGAATACCAGCAGCTGCACAAAATGT
GTGAGGATGACAGCCGCTCGTACGCCAGCTCATTCTCTGGATATTCAACAAATACAAAGTATGACCCACACCAAATTAAAGCAGAAATAG
CAAGTCGTCGGGATAGGCTTTCCAGATTAAAACGAGAGCTGACCCAGATGAAGCAGGAACTGCAGTACAAAGAAAAGGGGGTGGAGACCC
TGCAAGAGATTGATCGGAAGATGTCAAGTACTCACACCAGCTACAAACTGGATGAGGCGCAGGCTATCATGAGTGAGCTCCGGACCATCA
AGAAGGCCATTTGCACAGGCGAGAAGGAGAGGCGGGACCTGATGCATAGCCTGGCCAAGCTGACCGATAGCTTCAAGAACAGCTGCTCCG
TTACCGACTCTCTAGTGGACTTCCCTCACCATGTAGGCGTGCCTGGCGATGCTGGTGTACCCCAGCAGTTCTGCGATGCCGGCTCCCAGA
CTGATATCATCGGGGAGTTTGTCTTTGATGATAAAACAAGACTTGTAGACCGAGTCAGACTTAATTGGCAATATGAAGAAGCCAGAAAGA
GAGTCGCCAACATCCAGCAGCAGCTGGCCCGGCTTGACAATGAGTCCTGGCCAAGCACGGCCGAGGCTGACAGGGACCGGCTGCAGCTCA
TCAAGGAGAAGGAGGCCCTGCTGCAGGAGCTTCAGCTCATCATTGCACAGCGCCGCTCTGCGGGAGATGTGGCCCGGCTGGAGGAGGAGC
GGGAGCGCCTAGAGGAGGAGCTGCGGCGTGCACGGGCCACCTCCGCACAGGGCGCCACGGAGAGGATTCTGCTTCAGGAAAAAAGGAATT
GTCTACTTATGCAGCTGGAAGAAGCCACCCGCTTAACATCCTACCTCCAGTCCCAGTTAAAAAGCCTGTGTGCCAGCACCCTGACGGTGT
CCTCGGGGAGCAGCCGCGGGTCCCTAGCCTCCAGCCGTGGGTCTCTGGCCTCCAGCCGGGGCTCCCTGAGCTCGGTCAGCTTCACGGACA
TCTACGGCCTCCCGCAGTACGAGAAGCCCGACGCTGAGGGCAGCCAGCTTCTACGCTTCGACCTCATTCCCTTCGACTCTCTGGGGCGAG
ATGCTCCCTTTTCAGAGCCCCCAGGCCCCTCGGGCTTCCACAAGCAGAGGCGGTCCCTGGACACGCCCCAGTCCCTGGCATCGCTGTCCT
CCCGCTCCTCGCTGTCCTCGCTGTCGCCCCCAAGCTCGCCCCTGGACACGCCCTTCCTCCCTGCCTCACGGGACTCGCCGCTGGCGCAGC
TGGCGGACAGCTGTGAGGGGCCAGGCCTGGGCGCCCTAGACAGACTGCGGGCACACGCCTCGGCTATGGGGGACGAAGACTTACCAGGCA
TGGCGGCCCTTCAGCCACACGGGGTCCCCGGGGATGGGGAAGGGCCGCACGAGCGAGGACCCCCACCAGCCAGCGCTCCCGTGGGTGGAA
CAGTGACTCTTCGAGAAGACAGTGCCAAGAGGTTGGAGAGGAGGGCACGCCGCATCTCCGCATGTCTGTCGGATTATTCGCTAGCCAGCG
ACAGTGGGGTGTTTGAACCTCTAACCAAAAGGAACGAAGATGCCGAGGAGCCTGCCTACGGAGACACGGCCAGTAACGGAGATCCCCAGA
TCCACGTGGGACTCCTGCGCGACAGTGGCAGCGAGTGTCTCCTCGTGCACGTGCTGCAGCTGAAGAACCCGGCGGGGCTGGCGGTGAAGG
AAGACTGCAAAGTCCACATCCGAGTCTATTTGCCCCCACTGGACTCGGGCACGCCCAACACTTACTGCTCCAAGGCTCTGGAGTTCCAAG
TGCCGCTGGTGTTTAACGAAGTGTTCAGAATCCCCGTGCATTCCAGCGCGTTGACACTGAAGTCACTTCAGTTATACGTGTGTTCAGTGA
CTCCGCAGCTGCAGGAAGAACTGCTGGGCATTGCTCAGATTAACCTGGCTGACTATGACAGTTTGAGTGAGATGCAGCTGCGCTGGCATT
CCGTGCAGGTGTTCACCAGCTCTGAACCATCAAGGACGCGGGAGGCTGGGTGTGCAGGAGAGAGCTCCGCCCGGGACCCTGCACACACCA
TCTCCATCTCCGGCAAGACGGATGCGGTGACGGTGCTCCTGGCCAGAACCACGGCACAGCTGCAGGCGGTGGAGAGGGAACTGGCCGAGG
AGCGGGCCAAGCTGGAGTACACGGAGGAGGAGGTCCTGGAGATGGAGCGCAAGGAGGAGCAGGCCGAGGCCATATCCGAGCGGAGTTGGC
AAGCGGACTCGGTGGATAGCGGCTGTAGCAACTGCACCCAGACCAGCCCTCCGTACCCAGAGCCCTGTTGCATGGGTATCGACTCCATCC
TGGGCCACCCATTTGCTGCTCAGGCAGGGCCTTACAGCCCCGAGAAATTTCAGCCCTCGCCTCTTAAGGTTGATAAGGAAACCAACACGG
AAGATCTCTTTCTGGAAGAAGCAGCCAGCCTCGTGAAGGAGCGGCCCAGCCGCCGGGCCCGAGGGTCGCCTTTTGTTCGGAGTGGCACGA
TTGTCCGTTCCCAGACATTCTCGCCTGGAGCACGAAGCCAGTATGTTTGCAGAATTGAAGAGGGCAGTAAAGCCGCGGCGGTCGACAAGT
TACTGGCTGGAGATGAGATCGTCGGCATCAATGACATTGGTCTCTCAGGGTTTAGACAGGAAGCGATTTGCCTGGTGAAGGGGTCCCATA
AGACCCTGAAGCTGGTCGTCAAAAGGAGGAGCGAGCTGGGCTGGAGGCCTCACTCCTGGCATGCCACCAAGTTCTCTGACAGCCACCCCG
AGCTAGCGGCCTCCCCATTCACCTCCACCAGCGGCTGTCCTTCCTGGTCCGGCCGACACCACGCGAGTTCTTCCTCCCACGACCTGTCCA
GTTCCTGGGAGCAGACGAACCTACAGCGCACCTTAGATCACTTCAGCTCCTTGGGGAGCGTTGACAGCCTGGACCACCCCTCCAGTCGCC
TCTCGGTGGCCAAGTCCAACAGCAGCATCGACCACCTGGGCAGCCACAGCAAGCGCGACTCGGCCTACGGCTCCTTCTCCACCAGCTCTA
GCACTCCTGACCACACCTTGTCCAAAGCCGACACGTCCTCCGCAGAGAACATCCTCTACACTGTGGGCCTCTGGGAGGCTCCCAGGCAGG
GTGGCCGGCAGGCCCAGGCCGCAGGCGACCCTCAGGGCTCGGAGGAGAAGCTCAGTTGTTTCCCGCCCAGGGTCCCCGGTGACAGCGGCA
AAGGCCCCAGGCCAGAGTACAATGCCGAGCCCAAGCTGGCTGCCCCTGGGAGGTCCAATTTTGGGCCAGTCTGGTATGTTCCCGATAAGA
AGAAAGCACCATCATCCCCACCTCCTCCCCCTCCCCCTCTCCGCAGTGACAGCTTTGCTGCCACCAAGAGCCACGAGAAGGCCCAGGGCC
CTGTGTTCTCAGAGGCGGCTGCGGCACAGCACTTTACGGCCCTGGCCCAGGCTCAGCCTCGTGGTGACCGGAGACCAGAGCTCACCGATC
GGCCTTGGAGGTCAGCACACCCGGGGAGCCTCGGGAAGGGATCGGGAGGCCCGGGCTGCCCACAGGAGGCCCACGCAGACGGCAGCTGGC
CGCCCTCCAAGGATGGAGCTTCCAGTAGGCTGCAGGCCTCTCTGTCCAGCTCAGATGTGCGCTTCCCTCAGTCTCCTCATAGCGGCCGAC
ACCCTCCCCTATACAGCGACCACAGCCCCCTCTGTGCTGACAGCCTTGGGCAGGAGCCAGGGGCTGCCAGCTTCCAGAACGACAGCCCTC
CTCAGGTGAGGGGGCTCAGCAGCTGTGACCAGAAGCTGGGGAGCGGCTGGCAGGGTCCCCGGCCCTGTGTGCAGGGAGACCTGCAAGCAG
CACAGCTCTGGGCGGGATGCTGGCCTTCTGACACAGCCCTTGGAGCCCTCGAGAGTCTTCCCCCACCCACGGTGGGCCAGAGCCCACGCC
ATCACCTACCTCAGCCTGAGGGTCCTCCGGATGCCCGCGAGACAGGACGGTGTTACCCGCTGGACAAAGGGGCCGAGGGCTGCTCCGCGG
GAGCCCAGGAGCCTCCCAGGGCCAGCCGTGCAGAAAAAGCCAGCCAGAGGCTGGCAGCCAGCATCACGTGGGCAGATGGGGAGAGCAGCA
GGATCTGCCCGCAGGAGACGCCCCTGTTGCACTCCCTGACCCAGGAGGGGAAGCGCCGGCCTGAGAGCAGTCCAGAGGACAGCGCCACCA
GACCGCCACCGTTCGACGCCCACGTGGGCAAGCCCACCCGAAGAAGCGACCGCTTTGCCACCACCCTGCGGAATGAGATCCAGATGCATA
GAGCCAAGCTGCAGAAGAGCCGGAGCACAGTGGCTCTGACTGCAGCAGGGGAGGCGGAGGATGGCACCGGCCGCTGGAGGGCCGGGTTGG
GAGGTGGCACCCAGGAAGGACCCCTCGCTGGCACCTATAAAGACCACCTGAAAGAGGCCCAAGCCCGGGTCCTGAGGGCCACGTCCTTCA
AGCGCCGCGACTTGGACCCCAACCCAGGAGACCTATACCCGGAGTCACTGGAACACCGGATGGGGGATCCAGACACTGTCCCCCACTTCT
GGGAGGCAGGCCTGGCCCAGCCACCCTCATCTACAAGTGGCGGGCCCCACCCGCCCCGCATCGGAGGCCGGAGACGGTTCACAGCTGAGC
AGAAATTGAAGTCCTACTCGGAACCTGAGAAGATGAACGAGGTGGGCCTCACGAGGGGCTACAGTCCTCACCAGCACCCCAGGACATCTG
AGGATACTGTGGGCACGTTTGCTGACAGGTGGAAGTTTTTTGAGGAAACGAGCAAACCTGTTCCCCAGAGGCCTGCCCAGAAGCAAGCTC
TTCACGGAATCCCGAGAGACAAGCCAGAGAGGCCGCGGACAGCGGGCCGCACATGTGAGGGCACGGAGCCCTGGTCGCGCACCACCTCCC
TTGGGGACAGCCTCAACGCTCACAGCGCAGCGGAGAAGGCAGGGACTTCAGACCTGCCGCGGAGGCTCGGCACCTTTGCAGAGTATCAGG
CCTCTTGGAAGGAACAGAGGAAACCTCTGGAGGCCAGGAGCTCTGGGCGCTGCCACTCAGCGGATGACATCCTGGATGTGAGCCTGGACC
CACAGGAGAGGCCGCAGCACGTTCATGGGAGGTCCCGGTCTTCACCGTCCACAGACCACTACAAGCAGGAAGCTTCTGTCGAACTGCGAA
GGCAGGCAGGGGACCCCGGCGAGCCCAGAGAAGAGCTTCCCTCCGCAGTCCGGGCCGAGGAGGGACAGTCCACGCCGAGACAAGCAGATG
CCCAGTGTCGGGAAGGCAGCCCAGGATCACAGCAGCACCCACCGAGTCAGAAGGCACCGAACCCACCCACATTCTCTGAACTATCTCACT
GCCGGGGAGCCCCAGAGCTGCCCCGGGAGGGCCGGGGCCGAGCGGGAACCCTACCTCGAGATTATAGATACTCGGAGGAGAGCACCCCAG
CAGACTTGGGACCCCGAGCCCAGAGCCCTGGCTCACCCCTGCATGCTCGAGGACAAGACTCGTGGCCAGTGAGCTCAGCCCTGCTCTCCA
AGAGGCCAGCCCCACAGAGGCCACCGCCACCCAAGCGCGAGCCCAGGAGATACAGGGCCACAGACGGCGCACCTGCTGACGCCCCCGTGG
GCGTCCTCGGCAGGCCCTTCCCAACGCCATCCCCTGCGTCCCTGGATGTGTATGTGGCCCGCCTGTCCCTCTCCCACAGCCCCTCTGTGT
TCAGCAGTGCCCAGCCCCAGGACACCCCGAAGGCCACTGTCTGTGAGCGTGGAAGCCAGCATGTGAGCGGGGACGCATCACGTCCTCTGC
CAGAAGCACTGCTCCCTCCCAAGCAGCAGCACCTGCGCCTGCAGACGGCCACCATGGAGACCTCGCGCTCCCCCTCGCCCCAGTTCGCCC
CCCAGAAACTGACGGACAAACCTCCCCTGCTCATCCAGGATGAGGATTCAACCAGAATTGAGCGGGTGATGGACAACAACACCACGGTGA
AGATGGTGCCCATCAAGATCGTGCACTCGGAGAGCCAGCCAGAGAAGGAGAGCCGCCAGAGCCTGGCATGCCCCGCCGAGCCACCTGCCC
TGCCCCACGGGCTGGAGAAAGACCAGATCAAGACGCTGAGCACATCTGAGCAGTTCTACTCGCGCTTCTGTCTGTACACGCGGCAGGGTG
CTGAGCCCGAGGCCCCACATAGGGCCCAGCCGGCTGAGCCCCAGCCCCTGGGCACCCAGGTGCCCCCCGAGAAAGACCGCTGCACCTCCC
CTCCAGGGCTCAGCTACATGAAGGCCAAAGAGAAGACTGTGGAAGACCTGAAGTCGGAGGAGCTGGCCAGGGAGATCGTGGGGAAGGATA
AGTCCCTGGCCGACATCCTGGATCCCAGTGTGAAGATCAAAACCACTATGGACTTGATGGAAGGCATCTTCCCCAAAGACGAGCACCTCC
TGGAAGAAGCCCAGCAACGGAGGAAGCTGCTCCCCAAAATCCCCTCTCCTAGAAGCACAGAGGAGAGGAAAGAGGAGCCCAGCGTGCCTG
CGGCCGTGTCCCTGGCCACCAATTCTACCTACTACAGCACGTCGGCCCCCAAGGCGGAGCTGCTGATCAAGATGAAGGACCTGCAGGAGC
AGCAGGAGCACGAAGAGGATTCGGGAAGCGACTTGGACCACGACCTGTCGGTGAAGAAGCAGGAGCTCATCGAGAGCATCAGCCGCAAGC
TGCAGGTGCTCCGGGAGGCCCGCGAGAGCCTGCTGGAGGACGTGCAGGCCAACACCGTGCTGGGGGCCGAGGTGGAGGCCATCGTGAAAG
GCGTCTGCAAGCCCAGCGAGTTTGACAAGTTCCGGATGTTCATTGGAGACCTGGACAAAGTGGTGAACCTCCTGCTGTCGCTGTCAGGCC
GCCTGGCCCGGGTGGAGAATGCCCTCAATAATTTGGACGACGGCGCTTCTCCCGGTGATCGGCAATCACTGCTTGAGAAGCAGAGAGTCC
TGATCCAGCAGCACGAGGACGCCAAGGAGCTCAAGGAGAACCTGGACCGCCGCGAGCGCATCGTCTTTGACATTTTGGCCAACTATCTGA
GCGAGGAGAGCCTCGCGGACTATGAGCACTTCGTGAAGATGAAGTCGGCCCTCATCATCGAGCAGCGGGAGCTGGAAGATAAAATCCACC
TTGGTGAAGAGCAGCTGAAGTGCTTATTGGACAGCCTTCAGCCCGAAAGGGGCAAATAAGAGACCAGTCCCCGGTGGAGGAGGGGCACGG
GGCCTCCGAGCTCCAGCTCCGTTCCCAAGGATACTCGTGAAGACCCCATCTGTGTTCATGGCCTGGAAAGAGACTTCTCCCATAGCAAAG
AGGCTGTTATAAAAGCAATAACTTTTGTGTTTGTGTGGGATGATTTATTTAATTTTTTAGTTTCCCCTTTGATTGCTGAGAGCCATTTTC
CTTTACACATAACTACACCTGACACCAGGCTCTGCTGGATGTGAGTTTCCACTGCATGGGCTGTGGGCTGGGCCTGTGGTGCCTGCCGAG
TGGTCACTGTCAGTGGGAAACCCGTTGTTCCTCCCGTCTTCAGATGCTGAGCCAACTGCTTGGACAGCAGCCAGCGCGTCATGACGTGCA
TGAGAGGGGGACCCTGGTGCTCATCTTCTCTTGTCATTCATCCAGGCATGGGCTGCCAGGTTTTGTCCCTGCTCGTTCAACAGTGTGAGC
ATTTGTCTCTGTTATCTAATGATGTTCTCTGACCCAGCAGAAATCATCATCATGATGATGATAATTTATTAACTTTTTGGAAGGGTGAAT
AGTTTCCTAATGGTTAAAAACCAACTGTGAAAGGAACCACCTGTGTGGTTGGGTTCACTCATTCTCAGATTAAATTGCCACTTAAAGAAA
TAACGTGCATGCTTTAAAAAACACAGTCACGCACCAAGCAGGCAAATAGCTTTAGTCCTTCTCACCTCACATCACAGTTGTTCTGCAAAG
TAAAATTTTTTGGTTAAGAGCGTGTCCAGTAGTAATGTGCTTGTTAGCTGTTTCTCAAGACCAACAGAAGATTTTTTCAGTTACTTTCCC
CCCATGTATTTTGTATGCATATGATTGTCCGTGATAATTGGCTACTTTTCCATTGTTTCCTCCTTAAATCGTTTAGCATGGCATGAGGGC
CACATTCCATGGACGGGAAGACCCCTTCCTCTTCAGAGGTCCCGTGGACTACACAGCTCCTGAGCTTGATCTTTTTCTGCCATGAAGTTT
AAAGATTCTATGCCCATTTCCTTGATTGAAATGGCAGGATTCTAAAGAGAGCCTGGTTTGTTAAAAGAAAACACTGTCATGCTGTCAGTT
CCCAATTGACAAGTCACAGACTGGGAGAAAATATTTGCAAATCGTGTATCTGACAAAAGGTTTGTGTCCAGGATGTACAAAGAACTCTCA
AACCGGATAGTAAGAAAACAAACAGCCCAAGTGAAAAGCAGGCAAAAGACTTGAATAGACACTTCACCAAAGAGCATACACGCGTGGCAA
ACAAGCACACGAAAAGACGTTCAGCCGCCGATGGCTTGGTTATAATTTATAACTTACTTATTTTTATCTAATAATTGTAGATTCAGTGTA
TTTCTTCAAAAAATGTTTAATTAAATGCATGTTAATGGTGAGTGAATCCCTTGGGTGACTTCGTGTTTAGGTCGTATTAGGGCATTTGTT
GGATCAACGGATCATTTTAACCCTGACTTCCCCTTATTCCCATAAAAGAAGTTTTCCAGTGGAATGGAGATTTCATTTTGTCAGCAGCAG
TGACCACAGCCTTACCAAAGCAGACGCGTGCGCGTGCACAGATGCACACACACAGATGTCTTAAAAGACTAGAATCCACACTTCCTGAGC
CAGAGGGGCCGTGTTGACGGTAATGCATTCTCTATAGAGCCAAGTCCAAACTGGCAAGCTCAATGATGCAGGCAATAAACCGCCTTTTTG
GCAGCCTACCAATGCCAAAAGGATAAATGTCTTTCCAAAAGTGTGTATTCCTGTTAAATTAAGCTCTTGCTAACTTGAAAAATCCCTGTT
CTGCCAGCGAAGCTTCCTCCTCCTCTCCAGCTGGTAGTCACTTGCGTGAATGCTGGTCAGTCTGAAAAGGTGAAGCTGGCTGTGCACTTA
CCCCCATCTTTCTCCCTCGGGGAGACGACCCAAGGAATTTCAGAGTATTTTGTTTGGCAGAGCTTTTACCTGTTATTCTTTGCCCTCAAA
TACAGTATTGTGGTCATTTTGATGATATGTGTGTAAAATGTGAATAATCCAATTGGTGTCTGTACTCAGCCTTTTGATGTCTTTTTAGGA
CTTTCTCTTCTACACAGCAATACGTCGTGCTCGAGTATCCTTGTAGCAAAGCACATAGAGCCAGCTGTCCTGTCAGTTCCCCTGTTTGCC
TCTGAAACGTCTGGTTAGTGGGGACCCAAAGATTCTAGTGAGTCAACATCCATAACTCTGTATCTAGTTGTATTATTCATAGAAAATCAA
TCTGGTGCTAATGGTTGGCCCTGGTGTTGTTGGGTGGCAGCTGCTCCTTCGCCCTCTTGTAGTGTGGCTGTGGAGGGCTCTGCCTATGGG
GGGTGGCCTGTGGCTTGTATCCTTCAGTCCACCACAGCAAATGTGTGTAGATTTCATGCTCGACACTTACCACTCACCTATCAACAGATC

>99471_99471_2_WWC3-SHROOM2_WWC3_chrX_10102636_ENST00000454666_SHROOM2_chrX_9841692_ENST00000380913_length(amino acids)=2482AA_BP=921
MDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQLHKMCEDDSRSYASSFSGYSTNTKYDPHQIK
AEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRKMSSTHTSYKLDEAQAIMSELRTIKKAICTGEKERRDLMHSLAKLTDSFKN
SCSVTDSLVDFPHHVGVPGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRVRLNWQYEEARKRVANIQQQLARLDNESWPSTAEADRDR
LQLIKEKEALLQELQLIIAQRRSAGDVARLEEERERLEEELRRARATSAQGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCAST
LTVSSGSSRGSLASSRGSLASSRGSLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAPFSEPPGPSGFHKQRRSLDTPQSLA
SLSSRSSLSSLSPPSSPLDTPFLPASRDSPLAQLADSCEGPGLGALDRLRAHASAMGDEDLPGMAALQPHGVPGDGEGPHERGPPPASAP
VGGTVTLREDSAKRLERRARRISACLSDYSLASDSGVFEPLTKRNEDAEEPAYGDTASNGDPQIHVGLLRDSGSECLLVHVLQLKNPAGL
AVKEDCKVHIRVYLPPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQINLADYDSLSEMQL
RWHSVQVFTSSEPSRTREAGCAGESSARDPAHTISISGKTDAVTVLLARTTAQLQAVERELAEERAKLEYTEEEVLEMERKEEQAEAISE
RSWQADSVDSGCSNCTQTSPPYPEPCCMGIDSILGHPFAAQAGPYSPEKFQPSPLKVDKETNTEDLFLEEAASLVKERPSRRARGSPFVR
SGTIVRSQTFSPGARSQYVCRIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVKRRSELGWRPHSWHATKFSD
SHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDSLDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFS
TSSSTPDHTLSKADTSSAENILYTVGLWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGPVWYV
PDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHAD
GSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGD
LQAAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDARETGRCYPLDKGAEGCSAGAQEPPRASRAEKASQRLAASITWADG
ESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQKSRSTVALTAAGEAEDGTGRWR
AGLGGGTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGDPDTVPHFWEAGLAQPPSSTSGGPHPPRIGGRRRF
TAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVGTFADRWKFFEETSKPVPQRPAQKQALHGIPRDKPERPRTAGRTCEGTEPWSR
TTSLGDSLNAHSAAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADDILDVSLDPQERPQHVHGRSRSSPSTDHYKQEASV
ELRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYSEE
STPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHS
PSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNN
TTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCLYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDR
CTSPPGLSYMKAKEKTVEDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEERKEEP
SVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGAEVEA
IVKGVCKPSEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELKENLDRRERIVFDILA

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Fusion Gene PPI Analysis for WWC3-SHROOM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WWC3-SHROOM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WWC3-SHROOM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource