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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WWOX-ABI1 (FusionGDB2 ID:99472)

Fusion Gene Summary for WWOX-ABI1

check button Fusion gene summary
Fusion gene informationFusion gene name: WWOX-ABI1
Fusion gene ID: 99472
HgeneTgene
Gene symbol

WWOX

ABI1

Gene ID

51741

10006

Gene nameWW domain containing oxidoreductaseabl interactor 1
SynonymsD16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1ABI-1|ABLBP4|E3B1|NAP1BP|SSH3BP|SSH3BP1
Cytomap

16q23.1-q23.2

10p12.1

Type of geneprotein-codingprotein-coding
DescriptionWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1abl interactor 1Abelson interactor 1Abl-interactor protein 1 longabl-binding protein 4eps8 SH3 domain-binding proteininteractor protein AblBP4nap1 binding proteinspectrin SH3 domain-binding protein 1
Modification date2020031320200327
UniProtAcc.

Q8IZP0

Ensembl transtripts involved in fusion geneENST00000355860, ENST00000402655, 
ENST00000406884, ENST00000408984, 
ENST00000539474, ENST00000565791, 
ENST00000566780, ENST00000569818, 
ENST00000346832, ENST00000355394, 
ENST00000359188, ENST00000376134, 
ENST00000376137, ENST00000376138, 
ENST00000376139, ENST00000376142, 
ENST00000376160, ENST00000376166, 
ENST00000376170, ENST00000490841, 
ENST00000536334, ENST00000376140, 
ENST00000473481, 
Fusion gene scores* DoF score26 X 26 X 8=540814 X 8 X 5=560
# samples 3113
** MAII scorelog2(31/5408*10)=-4.12475503100795
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/560*10)=-2.10691520391651
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WWOX [Title/Abstract] AND ABI1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWWOX(78787691)-ABI1(27035825), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

HgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691

TgeneABI1

GO:0018108

peptidyl-tyrosine phosphorylation

17101133


check buttonFusion gene breakpoints across WWOX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABM150882WWOXchr16

78787691

-ABI1chr10

27035825

+


Top

Fusion Gene ORF analysis for WWOX-ABI1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000355860ENST00000346832WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000355860ENST00000355394WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000355860ENST00000359188WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000355860ENST00000376134WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000355860ENST00000376137WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000355860ENST00000376138WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000355860ENST00000376139WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000355860ENST00000376142WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000355860ENST00000376160WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000355860ENST00000376166WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000355860ENST00000376170WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000355860ENST00000490841WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000355860ENST00000536334WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000346832WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000355394WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000359188WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000376134WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000376137WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000376138WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000376139WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000376142WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000376160WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000376166WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000376170WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000490841WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000402655ENST00000536334WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000346832WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000355394WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000359188WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000376134WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000376137WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000376138WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000376139WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000376142WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000376160WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000376166WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000376170WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000490841WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000406884ENST00000536334WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000346832WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000355394WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000359188WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000376134WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000376137WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000376138WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000376139WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000376142WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000376160WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000376166WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000376170WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000490841WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000408984ENST00000536334WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000346832WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000355394WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000359188WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000376134WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000376137WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000376138WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000376139WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000376142WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000376160WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000376166WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000376170WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000490841WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000539474ENST00000536334WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000346832WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000355394WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000359188WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000376134WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000376137WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000376138WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000376139WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000376142WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000376160WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000376166WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000376170WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000490841WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000565791ENST00000536334WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000346832WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000355394WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000359188WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000376134WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000376137WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000376138WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000376139WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000376142WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000376160WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000376166WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000376170WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000490841WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000566780ENST00000536334WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000346832WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000355394WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000359188WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000376134WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000376137WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000376138WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000376139WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000376142WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000376160WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000376166WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000376170WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000490841WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-3UTRENST00000569818ENST00000536334WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000355860ENST00000376140WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000355860ENST00000473481WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000402655ENST00000376140WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000402655ENST00000473481WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000406884ENST00000376140WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000406884ENST00000473481WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000408984ENST00000376140WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000408984ENST00000473481WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000539474ENST00000376140WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000539474ENST00000473481WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000565791ENST00000376140WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000565791ENST00000473481WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000566780ENST00000376140WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000566780ENST00000473481WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000569818ENST00000376140WWOXchr16

78787691

-ABI1chr10

27035825

+
intron-intronENST00000569818ENST00000473481WWOXchr16

78787691

-ABI1chr10

27035825

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for WWOX-ABI1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for WWOX-ABI1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:78787691/:27035825)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABI1

Q8IZP0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for WWOX-ABI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for WWOX-ABI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WWOX-ABI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WWOX-ABI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource