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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WWOX-C15orf41 (FusionGDB2 ID:99475)

Fusion Gene Summary for WWOX-C15orf41

check button Fusion gene summary
Fusion gene informationFusion gene name: WWOX-C15orf41
Fusion gene ID: 99475
HgeneTgene
Gene symbol

WWOX

C15orf41

Gene ID

51741

84529

Gene nameWW domain containing oxidoreductasechromosome 15 open reading frame 41
SynonymsD16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1HH114
Cytomap

16q23.1-q23.2

15q14

Type of geneprotein-codingprotein-coding
DescriptionWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1protein C15orf41uncharacterized protein C15orf41
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000565791, ENST00000355860, 
ENST00000406884, ENST00000408984, 
ENST00000566780, ENST00000402655, 
ENST00000539474, ENST00000569818, 
ENST00000338183, ENST00000437989, 
ENST00000562877, ENST00000566621, 
ENST00000567389, ENST00000569302, 
ENST00000562489, ENST00000563167, 
ENST00000565792, 
Fusion gene scores* DoF score26 X 26 X 8=54088 X 5 X 7=280
# samples 3110
** MAII scorelog2(31/5408*10)=-4.12475503100795
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WWOX [Title/Abstract] AND C15orf41 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWWOX(78198186)-C15orf41(37100525), # samples:2
Anticipated loss of major functional domain due to fusion event.WWOX-C15orf41 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WWOX-C15orf41 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
WWOX-C15orf41 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

HgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check buttonFusion gene breakpoints across WWOX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C15orf41 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-5415-01AWWOXchr16

78198186

-C15orf41chr15

37100525

+
ChimerDB4GBMTCGA-06-5415-01AWWOXchr16

78198186

+C15orf41chr15

37100525

+


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Fusion Gene ORF analysis for WWOX-C15orf41

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000565791ENST00000338183WWOXchr16

78198186

+C15orf41chr15

37100525

+
3UTR-3CDSENST00000565791ENST00000437989WWOXchr16

78198186

+C15orf41chr15

37100525

+
3UTR-3CDSENST00000565791ENST00000562877WWOXchr16

78198186

+C15orf41chr15

37100525

+
3UTR-3CDSENST00000565791ENST00000566621WWOXchr16

78198186

+C15orf41chr15

37100525

+
3UTR-3CDSENST00000565791ENST00000567389WWOXchr16

78198186

+C15orf41chr15

37100525

+
3UTR-3CDSENST00000565791ENST00000569302WWOXchr16

78198186

+C15orf41chr15

37100525

+
3UTR-3UTRENST00000565791ENST00000562489WWOXchr16

78198186

+C15orf41chr15

37100525

+
3UTR-3UTRENST00000565791ENST00000563167WWOXchr16

78198186

+C15orf41chr15

37100525

+
3UTR-3UTRENST00000565791ENST00000565792WWOXchr16

78198186

+C15orf41chr15

37100525

+
5CDS-3UTRENST00000355860ENST00000562489WWOXchr16

78198186

+C15orf41chr15

37100525

+
5CDS-3UTRENST00000355860ENST00000563167WWOXchr16

78198186

+C15orf41chr15

37100525

+
5CDS-3UTRENST00000355860ENST00000565792WWOXchr16

78198186

+C15orf41chr15

37100525

+
5CDS-3UTRENST00000406884ENST00000562489WWOXchr16

78198186

+C15orf41chr15

37100525

+
5CDS-3UTRENST00000406884ENST00000563167WWOXchr16

78198186

+C15orf41chr15

37100525

+
5CDS-3UTRENST00000406884ENST00000565792WWOXchr16

78198186

+C15orf41chr15

37100525

+
5CDS-3UTRENST00000408984ENST00000562489WWOXchr16

78198186

+C15orf41chr15

37100525

+
5CDS-3UTRENST00000408984ENST00000563167WWOXchr16

78198186

+C15orf41chr15

37100525

+
5CDS-3UTRENST00000408984ENST00000565792WWOXchr16

78198186

+C15orf41chr15

37100525

+
5CDS-3UTRENST00000566780ENST00000562489WWOXchr16

78198186

+C15orf41chr15

37100525

+
5CDS-3UTRENST00000566780ENST00000563167WWOXchr16

78198186

+C15orf41chr15

37100525

+
5CDS-3UTRENST00000566780ENST00000565792WWOXchr16

78198186

+C15orf41chr15

37100525

+
Frame-shiftENST00000355860ENST00000338183WWOXchr16

78198186

+C15orf41chr15

37100525

+
Frame-shiftENST00000355860ENST00000567389WWOXchr16

78198186

+C15orf41chr15

37100525

+
Frame-shiftENST00000355860ENST00000569302WWOXchr16

78198186

+C15orf41chr15

37100525

+
Frame-shiftENST00000406884ENST00000338183WWOXchr16

78198186

+C15orf41chr15

37100525

+
Frame-shiftENST00000406884ENST00000567389WWOXchr16

78198186

+C15orf41chr15

37100525

+
Frame-shiftENST00000406884ENST00000569302WWOXchr16

78198186

+C15orf41chr15

37100525

+
Frame-shiftENST00000408984ENST00000338183WWOXchr16

78198186

+C15orf41chr15

37100525

+
Frame-shiftENST00000408984ENST00000567389WWOXchr16

78198186

+C15orf41chr15

37100525

+
Frame-shiftENST00000408984ENST00000569302WWOXchr16

78198186

+C15orf41chr15

37100525

+
Frame-shiftENST00000566780ENST00000338183WWOXchr16

78198186

+C15orf41chr15

37100525

+
Frame-shiftENST00000566780ENST00000567389WWOXchr16

78198186

+C15orf41chr15

37100525

+
Frame-shiftENST00000566780ENST00000569302WWOXchr16

78198186

+C15orf41chr15

37100525

+
In-frameENST00000355860ENST00000437989WWOXchr16

78198186

+C15orf41chr15

37100525

+
In-frameENST00000355860ENST00000562877WWOXchr16

78198186

+C15orf41chr15

37100525

+
In-frameENST00000355860ENST00000566621WWOXchr16

78198186

+C15orf41chr15

37100525

+
In-frameENST00000406884ENST00000437989WWOXchr16

78198186

+C15orf41chr15

37100525

+
In-frameENST00000406884ENST00000562877WWOXchr16

78198186

+C15orf41chr15

37100525

+
In-frameENST00000406884ENST00000566621WWOXchr16

78198186

+C15orf41chr15

37100525

+
In-frameENST00000408984ENST00000437989WWOXchr16

78198186

+C15orf41chr15

37100525

+
In-frameENST00000408984ENST00000562877WWOXchr16

78198186

+C15orf41chr15

37100525

+
In-frameENST00000408984ENST00000566621WWOXchr16

78198186

+C15orf41chr15

37100525

+
In-frameENST00000566780ENST00000437989WWOXchr16

78198186

+C15orf41chr15

37100525

+
In-frameENST00000566780ENST00000562877WWOXchr16

78198186

+C15orf41chr15

37100525

+
In-frameENST00000566780ENST00000566621WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000402655ENST00000338183WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000402655ENST00000437989WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000402655ENST00000562877WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000402655ENST00000566621WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000402655ENST00000567389WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000402655ENST00000569302WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000539474ENST00000338183WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000539474ENST00000437989WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000539474ENST00000562877WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000539474ENST00000566621WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000539474ENST00000567389WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000539474ENST00000569302WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000569818ENST00000338183WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000569818ENST00000437989WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000569818ENST00000562877WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000569818ENST00000566621WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000569818ENST00000567389WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3CDSENST00000569818ENST00000569302WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3UTRENST00000402655ENST00000562489WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3UTRENST00000402655ENST00000563167WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3UTRENST00000402655ENST00000565792WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3UTRENST00000539474ENST00000562489WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3UTRENST00000539474ENST00000563167WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3UTRENST00000539474ENST00000565792WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3UTRENST00000569818ENST00000562489WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3UTRENST00000569818ENST00000563167WWOXchr16

78198186

+C15orf41chr15

37100525

+
intron-3UTRENST00000569818ENST00000565792WWOXchr16

78198186

+C15orf41chr15

37100525

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000566780WWOXchr1678198186+ENST00000566621C15orf41chr1537100525+27828823661118250
ENST00000566780WWOXchr1678198186+ENST00000437989C15orf41chr1537100525+23898823661079237
ENST00000566780WWOXchr1678198186+ENST00000562877C15orf41chr1537100525+10128823661010215
ENST00000406884WWOXchr1678198186+ENST00000566621C15orf41chr1537100525+2541641125877250
ENST00000406884WWOXchr1678198186+ENST00000437989C15orf41chr1537100525+2148641125838237
ENST00000406884WWOXchr1678198186+ENST00000562877C15orf41chr1537100525+771641125769215
ENST00000408984WWOXchr1678198186+ENST00000566621C15orf41chr1537100525+250160185837250
ENST00000408984WWOXchr1678198186+ENST00000437989C15orf41chr1537100525+210860185798237
ENST00000408984WWOXchr1678198186+ENST00000562877C15orf41chr1537100525+73160185729215
ENST00000355860WWOXchr1678198186+ENST00000566621C15orf41chr1537100525+2516616100852250
ENST00000355860WWOXchr1678198186+ENST00000437989C15orf41chr1537100525+2123616100813237
ENST00000355860WWOXchr1678198186+ENST00000562877C15orf41chr1537100525+746616100744215

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000566780ENST00000566621WWOXchr1678198186+C15orf41chr1537100525+0.0041141920.9958858
ENST00000566780ENST00000437989WWOXchr1678198186+C15orf41chr1537100525+0.0028946060.9971054
ENST00000566780ENST00000562877WWOXchr1678198186+C15orf41chr1537100525+0.79791240.20208761
ENST00000406884ENST00000566621WWOXchr1678198186+C15orf41chr1537100525+0.002905540.9970945
ENST00000406884ENST00000437989WWOXchr1678198186+C15orf41chr1537100525+0.0023478370.99765223
ENST00000406884ENST00000562877WWOXchr1678198186+C15orf41chr1537100525+0.85343780.1465622
ENST00000408984ENST00000566621WWOXchr1678198186+C15orf41chr1537100525+0.0024934180.99750656
ENST00000408984ENST00000437989WWOXchr1678198186+C15orf41chr1537100525+0.0018569530.9981431
ENST00000408984ENST00000562877WWOXchr1678198186+C15orf41chr1537100525+0.73189750.26810247
ENST00000355860ENST00000566621WWOXchr1678198186+C15orf41chr1537100525+0.0027050260.99729496
ENST00000355860ENST00000437989WWOXchr1678198186+C15orf41chr1537100525+0.0018386610.9981614
ENST00000355860ENST00000562877WWOXchr1678198186+C15orf41chr1537100525+0.7885920.211408

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Fusion Genomic Features for WWOX-C15orf41


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WWOXchr1678198186+C15orf41chr1537100524+0.0075139840.992486
WWOXchr1678198186+C15orf41chr1537100524+0.0075139840.992486

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for WWOX-C15orf41


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:78198186/chr15:37100525)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWOXchr16:78198186chr15:37100525ENST00000355860+5616_49172190.0DomainWW 1
HgeneWWOXchr16:78198186chr15:37100525ENST00000355860+5657_90172190.0DomainWW 2
HgeneWWOXchr16:78198186chr15:37100525ENST00000406884+5616_49172235.0DomainWW 1
HgeneWWOXchr16:78198186chr15:37100525ENST00000406884+5657_90172235.0DomainWW 2
HgeneWWOXchr16:78198186chr15:37100525ENST00000408984+51016_49172311.6666666666667DomainWW 1
HgeneWWOXchr16:78198186chr15:37100525ENST00000408984+51057_90172311.6666666666667DomainWW 2
HgeneWWOXchr16:78198186chr15:37100525ENST00000566780+5916_49172415.0DomainWW 1
HgeneWWOXchr16:78198186chr15:37100525ENST00000566780+5957_90172415.0DomainWW 2
HgeneWWOXchr16:78198186chr15:37100525ENST00000355860+5650_55172190.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr15:37100525ENST00000406884+5650_55172235.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr15:37100525ENST00000408984+51050_55172311.6666666666667MotifNuclear localization signal
HgeneWWOXchr16:78198186chr15:37100525ENST00000566780+5950_55172415.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr15:37100525ENST00000355860+56131_137172190.0Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr15:37100525ENST00000406884+56131_137172235.0Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr15:37100525ENST00000408984+510131_137172311.6666666666667Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr15:37100525ENST00000566780+59131_137172415.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWOXchr16:78198186chr15:37100525ENST00000402655+1516_490312.0DomainWW 1
HgeneWWOXchr16:78198186chr15:37100525ENST00000402655+1557_900312.0DomainWW 2
HgeneWWOXchr16:78198186chr15:37100525ENST00000569818+1116_49037.0DomainWW 1
HgeneWWOXchr16:78198186chr15:37100525ENST00000569818+1157_90037.0DomainWW 2
HgeneWWOXchr16:78198186chr15:37100525ENST00000402655+1550_550312.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr15:37100525ENST00000569818+1150_55037.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr15:37100525ENST00000402655+15131_1370312.0Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr15:37100525ENST00000569818+11131_137037.0Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr15:37100525ENST00000355860+56209_273172190.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr15:37100525ENST00000402655+15209_2730312.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr15:37100525ENST00000406884+56209_273172235.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr15:37100525ENST00000408984+510209_273172311.6666666666667RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr15:37100525ENST00000566780+59209_273172415.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr15:37100525ENST00000569818+11209_273037.0RegionMediates targeting to the mitochondria


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Fusion Gene Sequence for WWOX-C15orf41


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99475_99475_1_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000355860_C15orf41_chr15_37100525_ENST00000437989_length(transcript)=2123nt_BP=616nt
GCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCC
ACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCAC
CAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGG
AGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGA
CCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCT
CCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCA
TGGTGCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGATTTGGGCCAGGCT
TAGTCATCTATTGGTATGGATTTATCCAGGAGCTGGACTGCAACCGGGAAAGGGGCATCCTGCTCAAAGCCTGTTTCCCCACGAACATTG
TCACCTTATGCCACAGCATAGCTTGACCCTGAAGATCCTGGAAGAGAAGCTGGGAGGAAAAGAGACCCAGCATTGCATTACCATCGTGGA
ATAATCTAGCGCAAACCTAGGAAAGCTGAAGCCACAAAGTCCAAAGCCACCTTTGTACTCACCTGCAGAGCTCCAGAAGACCTTGATGGC
AGCCTGCCTATGCTGTGTGTTTGCTATATTCAATCTTTACGGCTTCCTGACTTCTGTGACAGTAAGCCAAGTGCAAAAATACACTTGATG
AGAATTTCCTCTTTTAATAATGTTATTTGAACACCACATATTTTAGATTTATCTTATTTGAAAGTATTAGTTCCATTGTGCCTGGAAACC
ACACTCCTTTAGATTGGGGGCCGAGAGGCGACAACCCAACATTGAGGAGAGTTTATTTTTAAACATGGCTAGTTGTCAGTATGTACGTGA
GCTAGTATTTTTATGAGTCGAGTTTTTTAAAGGCACATTCTGTATACTGCTTAGTATATGCATTTTATACCATGTAATTATAAAACACTC
GAGTAAGTTCAGCATTAGAAATGTTTAGCTTTGTATGAACTGAGTGTGCCAGAAATAAACCTGGAGCAATTTTTAAATAAGCAAAATAAA
GGAGATTTTTCTATTTGTTCACTTTAATTTATTCACTTTTGTGTACTTTTATGTACTGCAAATCAGATTTCAGTCTAAAGCGAAACATCA
GTAAGTTAATAATAAACCTATCTTTTGGGAAGTTGAATATTAATCTGTACCCAAAACGTATTTAGTAAAATATTTGCCCCCGCCACCCTG
CCATGCTGACATAACAACTTTTATAATGTTGAATAGATGATATGGGAAATACTAATAACAACAATGTAATTTTTGCAGACAGCTTTAACT
TATATACATTGCTTGATTTTTTTCAAAAGACTAAATATGTCATTTATACTTTGTTTATTTTCTACCAAAGAAGGTTTGTAAAAATATGCC
TGCTGCTTTTCCTTTTGAAGGACACAAACCTGGTCCCAACATGTGTGGATTTTAACTCTGAGTGGGGTGCATTAAATCAAAAGAGAGAGG
CAGAAGATGAAATGCTAAAGAAGGGTCAGGCAAACTTCTGTTTCAGTATAAAATTCATCATGCAGGCTTCTGAGTGAAATAGAATGATTT
GAAACCACTACTGTATTGCCTGGATACACACACACACACACACACACACTTTATACAAAAATGTTAAAAGCAGGTTTCCTGGCATGTTCT
AAACTGTTTTTTCTTTAGGAATAAATTACATTTATCTGCACAGATGTTGAAAATCCTGTTAAACCCTTGTCAAGGATTTGTTTATTTTAC

>99475_99475_1_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000355860_C15orf41_chr15_37100525_ENST00000437989_length(amino acids)=237AA_BP=159
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWIWARLSHL

--------------------------------------------------------------
>99475_99475_2_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000355860_C15orf41_chr15_37100525_ENST00000562877_length(transcript)=746nt_BP=616nt
GCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCC
ACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCAC
CAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGG
AGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGA
CCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCT
CCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCA
TGGTGCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGATTTGGGCCAGGCT
TAGTCATCTATTGGTATGGATTTATCCAGGAGCTGGACTGCAACCGGGAAAGGGGCATCCTGCTCAAAGCCTGTTTCCCCACGAACATTG

>99475_99475_2_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000355860_C15orf41_chr15_37100525_ENST00000562877_length(amino acids)=215AA_BP=159
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWIWARLSHL

--------------------------------------------------------------
>99475_99475_3_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000355860_C15orf41_chr15_37100525_ENST00000566621_length(transcript)=2516nt_BP=616nt
GCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCC
ACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCAC
CAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGG
AGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGA
CCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCT
CCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCA
TGGTGCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGATTTGGGCCAGGCT
TAGTCATCTATTGGTATGGATTTATCCAGGAGCTGGACTGCAACCGGGAAAGGGGCATCCTGCTCAAAGCCTGTTTCCCCACGAACATTG
TCACCTTATGCCACAGCATAGCTTGACCCTGAAGATCCTGGAAGAGAAGCTGGGAGGAAAAGGTGAATCCGGAAGCAATTTTACTTTCCT
GCACTGTAAGATCCTGGCAACATCTGCCCTGAACTTCAGCTGAACTCTTGCTGCCCGTAGTCACACCACTACCTCTTTAGACAAACATAT
CAAGAGTTTCTGTTTTCCTTCATCCCTTGCTGATGTGAACAGCCAAGAACTACAGACACAACCCACTCATTATCAGCATTTCTGTCTCTG
TCAAACAATTAGTTTATAGATAGTCATAATCTTTCTTTCTTCCGGATGGTTTATCCTTGTATGCTGAACAAAAGAAAAAATGTGAAGACT
GAAAGGTGTGATTTTTCAATTCTCCTCCCAGTTACCGAATCACCCTCTTATTTTTTTTTCCCTAAGCCTCCGTTCACTGTCTCTCCCTCT
CCCTTTCTCTTCATGTGCACTCACAGAGACCCAGCATTGCATTACCATCGTGGAATAATCTAGCGCAAACCTAGGAAAGCTGAAGCCACA
AAGTCCAAAGCCACCTTTGTACTCACCTGCAGAGCTCCAGAAGACCTTGATGGCAGCCTGCCTATGCTGTGTGTTTGCTATATTCAATCT
TTACGGCTTCCTGACTTCTGTGACAGTAAGCCAAGTGCAAAAATACACTTGATGAGAATTTCCTCTTTTAATAATGTTATTTGAACACCA
CATATTTTAGATTTATCTTATTTGAAAGTATTAGTTCCATTGTGCCTGGAAACCACACTCCTTTAGATTGGGGGCCGAGAGGCGACAACC
CAACATTGAGGAGAGTTTATTTTTAAACATGGCTAGTTGTCAGTATGTACGTGAGCTAGTATTTTTATGAGTCGAGTTTTTTAAAGGCAC
ATTCTGTATACTGCTTAGTATATGCATTTTATACCATGTAATTATAAAACACTCGAGTAAGTTCAGCATTAGAAATGTTTAGCTTTGTAT
GAACTGAGTGTGCCAGAAATAAACCTGGAGCAATTTTTAAATAAGCAAAATAAAGGAGATTTTTCTATTTGTTCACTTTAATTTATTCAC
TTTTGTGTACTTTTATGTACTGCAAATCAGATTTCAGTCTAAAGCGAAACATCAGTAAGTTAATAATAAACCTATCTTTTGGGAAGTTGA
ATATTAATCTGTACCCAAAACGTATTTAGTAAAATATTTGCCCCCGCCACCCTGCCATGCTGACATAACAACTTTTATAATGTTGAATAG
ATGATATGGGAAATACTAATAACAACAATGTAATTTTTGCAGACAGCTTTAACTTATATACATTGCTTGATTTTTTTCAAAAGACTAAAT
ATGTCATTTATACTTTGTTTATTTTCTACCAAAGAAGGTTTGTAAAAATATGCCTGCTGCTTTTCCTTTTGAAGGACACAAACCTGGTCC
CAACATGTGTGGATTTTAACTCTGAGTGGGGTGCATTAAATCAAAAGAGAGAGGCAGAAGATGAAATGCTAAAGAAGGGTCAGGCAAACT
TCTGTTTCAGTATAAAATTCATCATGCAGGCTTCTGAGTGAAATAGAATGATTTGAAACCACTACTGTATTGCCTGGATACACACACACA
CACACACACACACTTTATACAAAAATGTTAAAAGCAGGTTTCCTGGCATGTTCTAAACTGTTTTTTCTTTAGGAATAAATTACATTTATC

>99475_99475_3_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000355860_C15orf41_chr15_37100525_ENST00000566621_length(amino acids)=250AA_BP=159
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWIWARLSHL

--------------------------------------------------------------
>99475_99475_4_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000406884_C15orf41_chr15_37100525_ENST00000437989_length(transcript)=2148nt_BP=641nt
GCAGTGCGCAGGCGTGAGCGGTCGGGCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCG
GGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGC
CTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAA
CTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATA
TAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACG
GCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCG
AAACCGCCAAGTCTTTTGCCCTCCATGGTGCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTT
TAGAAGAATGGATTTGGGCCAGGCTTAGTCATCTATTGGTATGGATTTATCCAGGAGCTGGACTGCAACCGGGAAAGGGGCATCCTGCTC
AAAGCCTGTTTCCCCACGAACATTGTCACCTTATGCCACAGCATAGCTTGACCCTGAAGATCCTGGAAGAGAAGCTGGGAGGAAAAGAGA
CCCAGCATTGCATTACCATCGTGGAATAATCTAGCGCAAACCTAGGAAAGCTGAAGCCACAAAGTCCAAAGCCACCTTTGTACTCACCTG
CAGAGCTCCAGAAGACCTTGATGGCAGCCTGCCTATGCTGTGTGTTTGCTATATTCAATCTTTACGGCTTCCTGACTTCTGTGACAGTAA
GCCAAGTGCAAAAATACACTTGATGAGAATTTCCTCTTTTAATAATGTTATTTGAACACCACATATTTTAGATTTATCTTATTTGAAAGT
ATTAGTTCCATTGTGCCTGGAAACCACACTCCTTTAGATTGGGGGCCGAGAGGCGACAACCCAACATTGAGGAGAGTTTATTTTTAAACA
TGGCTAGTTGTCAGTATGTACGTGAGCTAGTATTTTTATGAGTCGAGTTTTTTAAAGGCACATTCTGTATACTGCTTAGTATATGCATTT
TATACCATGTAATTATAAAACACTCGAGTAAGTTCAGCATTAGAAATGTTTAGCTTTGTATGAACTGAGTGTGCCAGAAATAAACCTGGA
GCAATTTTTAAATAAGCAAAATAAAGGAGATTTTTCTATTTGTTCACTTTAATTTATTCACTTTTGTGTACTTTTATGTACTGCAAATCA
GATTTCAGTCTAAAGCGAAACATCAGTAAGTTAATAATAAACCTATCTTTTGGGAAGTTGAATATTAATCTGTACCCAAAACGTATTTAG
TAAAATATTTGCCCCCGCCACCCTGCCATGCTGACATAACAACTTTTATAATGTTGAATAGATGATATGGGAAATACTAATAACAACAAT
GTAATTTTTGCAGACAGCTTTAACTTATATACATTGCTTGATTTTTTTCAAAAGACTAAATATGTCATTTATACTTTGTTTATTTTCTAC
CAAAGAAGGTTTGTAAAAATATGCCTGCTGCTTTTCCTTTTGAAGGACACAAACCTGGTCCCAACATGTGTGGATTTTAACTCTGAGTGG
GGTGCATTAAATCAAAAGAGAGAGGCAGAAGATGAAATGCTAAAGAAGGGTCAGGCAAACTTCTGTTTCAGTATAAAATTCATCATGCAG
GCTTCTGAGTGAAATAGAATGATTTGAAACCACTACTGTATTGCCTGGATACACACACACACACACACACACACTTTATACAAAAATGTT
AAAAGCAGGTTTCCTGGCATGTTCTAAACTGTTTTTTCTTTAGGAATAAATTACATTTATCTGCACAGATGTTGAAAATCCTGTTAAACC

>99475_99475_4_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000406884_C15orf41_chr15_37100525_ENST00000437989_length(amino acids)=237AA_BP=159
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWIWARLSHL

--------------------------------------------------------------
>99475_99475_5_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000406884_C15orf41_chr15_37100525_ENST00000562877_length(transcript)=771nt_BP=641nt
GCAGTGCGCAGGCGTGAGCGGTCGGGCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCG
GGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGC
CTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAA
CTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATA
TAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACG
GCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCG
AAACCGCCAAGTCTTTTGCCCTCCATGGTGCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTT
TAGAAGAATGGATTTGGGCCAGGCTTAGTCATCTATTGGTATGGATTTATCCAGGAGCTGGACTGCAACCGGGAAAGGGGCATCCTGCTC

>99475_99475_5_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000406884_C15orf41_chr15_37100525_ENST00000562877_length(amino acids)=215AA_BP=159
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWIWARLSHL

--------------------------------------------------------------
>99475_99475_6_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000406884_C15orf41_chr15_37100525_ENST00000566621_length(transcript)=2541nt_BP=641nt
GCAGTGCGCAGGCGTGAGCGGTCGGGCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCG
GGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGC
CTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAA
CTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATA
TAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACG
GCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCG
AAACCGCCAAGTCTTTTGCCCTCCATGGTGCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTT
TAGAAGAATGGATTTGGGCCAGGCTTAGTCATCTATTGGTATGGATTTATCCAGGAGCTGGACTGCAACCGGGAAAGGGGCATCCTGCTC
AAAGCCTGTTTCCCCACGAACATTGTCACCTTATGCCACAGCATAGCTTGACCCTGAAGATCCTGGAAGAGAAGCTGGGAGGAAAAGGTG
AATCCGGAAGCAATTTTACTTTCCTGCACTGTAAGATCCTGGCAACATCTGCCCTGAACTTCAGCTGAACTCTTGCTGCCCGTAGTCACA
CCACTACCTCTTTAGACAAACATATCAAGAGTTTCTGTTTTCCTTCATCCCTTGCTGATGTGAACAGCCAAGAACTACAGACACAACCCA
CTCATTATCAGCATTTCTGTCTCTGTCAAACAATTAGTTTATAGATAGTCATAATCTTTCTTTCTTCCGGATGGTTTATCCTTGTATGCT
GAACAAAAGAAAAAATGTGAAGACTGAAAGGTGTGATTTTTCAATTCTCCTCCCAGTTACCGAATCACCCTCTTATTTTTTTTTCCCTAA
GCCTCCGTTCACTGTCTCTCCCTCTCCCTTTCTCTTCATGTGCACTCACAGAGACCCAGCATTGCATTACCATCGTGGAATAATCTAGCG
CAAACCTAGGAAAGCTGAAGCCACAAAGTCCAAAGCCACCTTTGTACTCACCTGCAGAGCTCCAGAAGACCTTGATGGCAGCCTGCCTAT
GCTGTGTGTTTGCTATATTCAATCTTTACGGCTTCCTGACTTCTGTGACAGTAAGCCAAGTGCAAAAATACACTTGATGAGAATTTCCTC
TTTTAATAATGTTATTTGAACACCACATATTTTAGATTTATCTTATTTGAAAGTATTAGTTCCATTGTGCCTGGAAACCACACTCCTTTA
GATTGGGGGCCGAGAGGCGACAACCCAACATTGAGGAGAGTTTATTTTTAAACATGGCTAGTTGTCAGTATGTACGTGAGCTAGTATTTT
TATGAGTCGAGTTTTTTAAAGGCACATTCTGTATACTGCTTAGTATATGCATTTTATACCATGTAATTATAAAACACTCGAGTAAGTTCA
GCATTAGAAATGTTTAGCTTTGTATGAACTGAGTGTGCCAGAAATAAACCTGGAGCAATTTTTAAATAAGCAAAATAAAGGAGATTTTTC
TATTTGTTCACTTTAATTTATTCACTTTTGTGTACTTTTATGTACTGCAAATCAGATTTCAGTCTAAAGCGAAACATCAGTAAGTTAATA
ATAAACCTATCTTTTGGGAAGTTGAATATTAATCTGTACCCAAAACGTATTTAGTAAAATATTTGCCCCCGCCACCCTGCCATGCTGACA
TAACAACTTTTATAATGTTGAATAGATGATATGGGAAATACTAATAACAACAATGTAATTTTTGCAGACAGCTTTAACTTATATACATTG
CTTGATTTTTTTCAAAAGACTAAATATGTCATTTATACTTTGTTTATTTTCTACCAAAGAAGGTTTGTAAAAATATGCCTGCTGCTTTTC
CTTTTGAAGGACACAAACCTGGTCCCAACATGTGTGGATTTTAACTCTGAGTGGGGTGCATTAAATCAAAAGAGAGAGGCAGAAGATGAA
ATGCTAAAGAAGGGTCAGGCAAACTTCTGTTTCAGTATAAAATTCATCATGCAGGCTTCTGAGTGAAATAGAATGATTTGAAACCACTAC
TGTATTGCCTGGATACACACACACACACACACACACACTTTATACAAAAATGTTAAAAGCAGGTTTCCTGGCATGTTCTAAACTGTTTTT
TCTTTAGGAATAAATTACATTTATCTGCACAGATGTTGAAAATCCTGTTAAACCCTTGTCAAGGATTTGTTTATTTTACATTAAACAAAT

>99475_99475_6_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000406884_C15orf41_chr15_37100525_ENST00000566621_length(amino acids)=250AA_BP=159
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWIWARLSHL

--------------------------------------------------------------
>99475_99475_7_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000408984_C15orf41_chr15_37100525_ENST00000437989_length(transcript)=2108nt_BP=601nt
GGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGC
AGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGT
TTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGG
ATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTT
TACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTT
CACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGTGCACATGTGAT
CTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGATTTGGGCCAGGCTTAGTCATCTATTGGT
ATGGATTTATCCAGGAGCTGGACTGCAACCGGGAAAGGGGCATCCTGCTCAAAGCCTGTTTCCCCACGAACATTGTCACCTTATGCCACA
GCATAGCTTGACCCTGAAGATCCTGGAAGAGAAGCTGGGAGGAAAAGAGACCCAGCATTGCATTACCATCGTGGAATAATCTAGCGCAAA
CCTAGGAAAGCTGAAGCCACAAAGTCCAAAGCCACCTTTGTACTCACCTGCAGAGCTCCAGAAGACCTTGATGGCAGCCTGCCTATGCTG
TGTGTTTGCTATATTCAATCTTTACGGCTTCCTGACTTCTGTGACAGTAAGCCAAGTGCAAAAATACACTTGATGAGAATTTCCTCTTTT
AATAATGTTATTTGAACACCACATATTTTAGATTTATCTTATTTGAAAGTATTAGTTCCATTGTGCCTGGAAACCACACTCCTTTAGATT
GGGGGCCGAGAGGCGACAACCCAACATTGAGGAGAGTTTATTTTTAAACATGGCTAGTTGTCAGTATGTACGTGAGCTAGTATTTTTATG
AGTCGAGTTTTTTAAAGGCACATTCTGTATACTGCTTAGTATATGCATTTTATACCATGTAATTATAAAACACTCGAGTAAGTTCAGCAT
TAGAAATGTTTAGCTTTGTATGAACTGAGTGTGCCAGAAATAAACCTGGAGCAATTTTTAAATAAGCAAAATAAAGGAGATTTTTCTATT
TGTTCACTTTAATTTATTCACTTTTGTGTACTTTTATGTACTGCAAATCAGATTTCAGTCTAAAGCGAAACATCAGTAAGTTAATAATAA
ACCTATCTTTTGGGAAGTTGAATATTAATCTGTACCCAAAACGTATTTAGTAAAATATTTGCCCCCGCCACCCTGCCATGCTGACATAAC
AACTTTTATAATGTTGAATAGATGATATGGGAAATACTAATAACAACAATGTAATTTTTGCAGACAGCTTTAACTTATATACATTGCTTG
ATTTTTTTCAAAAGACTAAATATGTCATTTATACTTTGTTTATTTTCTACCAAAGAAGGTTTGTAAAAATATGCCTGCTGCTTTTCCTTT
TGAAGGACACAAACCTGGTCCCAACATGTGTGGATTTTAACTCTGAGTGGGGTGCATTAAATCAAAAGAGAGAGGCAGAAGATGAAATGC
TAAAGAAGGGTCAGGCAAACTTCTGTTTCAGTATAAAATTCATCATGCAGGCTTCTGAGTGAAATAGAATGATTTGAAACCACTACTGTA
TTGCCTGGATACACACACACACACACACACACACTTTATACAAAAATGTTAAAAGCAGGTTTCCTGGCATGTTCTAAACTGTTTTTTCTT
TAGGAATAAATTACATTTATCTGCACAGATGTTGAAAATCCTGTTAAACCCTTGTCAAGGATTTGTTTATTTTACATTAAACAAATTTAT

>99475_99475_7_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000408984_C15orf41_chr15_37100525_ENST00000437989_length(amino acids)=237AA_BP=159
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWIWARLSHL

--------------------------------------------------------------
>99475_99475_8_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000408984_C15orf41_chr15_37100525_ENST00000562877_length(transcript)=731nt_BP=601nt
GGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGC
AGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGT
TTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGG
ATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTT
TACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTT
CACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGTGCACATGTGAT
CTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGATTTGGGCCAGGCTTAGTCATCTATTGGT
ATGGATTTATCCAGGAGCTGGACTGCAACCGGGAAAGGGGCATCCTGCTCAAAGCCTGTTTCCCCACGAACATTGTCACCTTATGCCACA

>99475_99475_8_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000408984_C15orf41_chr15_37100525_ENST00000562877_length(amino acids)=215AA_BP=159
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWIWARLSHL

--------------------------------------------------------------
>99475_99475_9_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000408984_C15orf41_chr15_37100525_ENST00000566621_length(transcript)=2501nt_BP=601nt
GGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGC
AGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGT
TTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGG
ATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTT
TACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTT
CACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGTGCACATGTGAT
CTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGATTTGGGCCAGGCTTAGTCATCTATTGGT
ATGGATTTATCCAGGAGCTGGACTGCAACCGGGAAAGGGGCATCCTGCTCAAAGCCTGTTTCCCCACGAACATTGTCACCTTATGCCACA
GCATAGCTTGACCCTGAAGATCCTGGAAGAGAAGCTGGGAGGAAAAGGTGAATCCGGAAGCAATTTTACTTTCCTGCACTGTAAGATCCT
GGCAACATCTGCCCTGAACTTCAGCTGAACTCTTGCTGCCCGTAGTCACACCACTACCTCTTTAGACAAACATATCAAGAGTTTCTGTTT
TCCTTCATCCCTTGCTGATGTGAACAGCCAAGAACTACAGACACAACCCACTCATTATCAGCATTTCTGTCTCTGTCAAACAATTAGTTT
ATAGATAGTCATAATCTTTCTTTCTTCCGGATGGTTTATCCTTGTATGCTGAACAAAAGAAAAAATGTGAAGACTGAAAGGTGTGATTTT
TCAATTCTCCTCCCAGTTACCGAATCACCCTCTTATTTTTTTTTCCCTAAGCCTCCGTTCACTGTCTCTCCCTCTCCCTTTCTCTTCATG
TGCACTCACAGAGACCCAGCATTGCATTACCATCGTGGAATAATCTAGCGCAAACCTAGGAAAGCTGAAGCCACAAAGTCCAAAGCCACC
TTTGTACTCACCTGCAGAGCTCCAGAAGACCTTGATGGCAGCCTGCCTATGCTGTGTGTTTGCTATATTCAATCTTTACGGCTTCCTGAC
TTCTGTGACAGTAAGCCAAGTGCAAAAATACACTTGATGAGAATTTCCTCTTTTAATAATGTTATTTGAACACCACATATTTTAGATTTA
TCTTATTTGAAAGTATTAGTTCCATTGTGCCTGGAAACCACACTCCTTTAGATTGGGGGCCGAGAGGCGACAACCCAACATTGAGGAGAG
TTTATTTTTAAACATGGCTAGTTGTCAGTATGTACGTGAGCTAGTATTTTTATGAGTCGAGTTTTTTAAAGGCACATTCTGTATACTGCT
TAGTATATGCATTTTATACCATGTAATTATAAAACACTCGAGTAAGTTCAGCATTAGAAATGTTTAGCTTTGTATGAACTGAGTGTGCCA
GAAATAAACCTGGAGCAATTTTTAAATAAGCAAAATAAAGGAGATTTTTCTATTTGTTCACTTTAATTTATTCACTTTTGTGTACTTTTA
TGTACTGCAAATCAGATTTCAGTCTAAAGCGAAACATCAGTAAGTTAATAATAAACCTATCTTTTGGGAAGTTGAATATTAATCTGTACC
CAAAACGTATTTAGTAAAATATTTGCCCCCGCCACCCTGCCATGCTGACATAACAACTTTTATAATGTTGAATAGATGATATGGGAAATA
CTAATAACAACAATGTAATTTTTGCAGACAGCTTTAACTTATATACATTGCTTGATTTTTTTCAAAAGACTAAATATGTCATTTATACTT
TGTTTATTTTCTACCAAAGAAGGTTTGTAAAAATATGCCTGCTGCTTTTCCTTTTGAAGGACACAAACCTGGTCCCAACATGTGTGGATT
TTAACTCTGAGTGGGGTGCATTAAATCAAAAGAGAGAGGCAGAAGATGAAATGCTAAAGAAGGGTCAGGCAAACTTCTGTTTCAGTATAA
AATTCATCATGCAGGCTTCTGAGTGAAATAGAATGATTTGAAACCACTACTGTATTGCCTGGATACACACACACACACACACACACACTT
TATACAAAAATGTTAAAAGCAGGTTTCCTGGCATGTTCTAAACTGTTTTTTCTTTAGGAATAAATTACATTTATCTGCACAGATGTTGAA

>99475_99475_9_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000408984_C15orf41_chr15_37100525_ENST00000566621_length(amino acids)=250AA_BP=159
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWIWARLSHL

--------------------------------------------------------------
>99475_99475_10_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000566780_C15orf41_chr15_37100525_ENST00000437989_length(transcript)=2389nt_BP=882nt
GTCCTGGCCCGAAACTGGATGCGCACGCCCCTTCCCTGCGGCGGGGAGGCTGACAAGGCTCCGCTCTATCTCTAGCGCCTCGGAGCGCTC
TCCGGCTTTGCTGTCTAGCCCGGCGGCAGCGCGATCTCTTAGGCACTTTCACCGCCTTCCTCTCCAGGCCCTGCCCCTTTGACGCCGGCC
GTCGCGATATTGCGGAGACTGGATTTCAGCTTCGTGGTCGGCGGAGCGGCCCCTGGAGGGCGCAGTGCGCAGGCGTGAGCGGTCGGGCCC
CGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAG
TCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAG
GACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGAT
TTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCA
AGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAG
GGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGT
GCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGATTTGGGCCAGGCTTAGT
CATCTATTGGTATGGATTTATCCAGGAGCTGGACTGCAACCGGGAAAGGGGCATCCTGCTCAAAGCCTGTTTCCCCACGAACATTGTCAC
CTTATGCCACAGCATAGCTTGACCCTGAAGATCCTGGAAGAGAAGCTGGGAGGAAAAGAGACCCAGCATTGCATTACCATCGTGGAATAA
TCTAGCGCAAACCTAGGAAAGCTGAAGCCACAAAGTCCAAAGCCACCTTTGTACTCACCTGCAGAGCTCCAGAAGACCTTGATGGCAGCC
TGCCTATGCTGTGTGTTTGCTATATTCAATCTTTACGGCTTCCTGACTTCTGTGACAGTAAGCCAAGTGCAAAAATACACTTGATGAGAA
TTTCCTCTTTTAATAATGTTATTTGAACACCACATATTTTAGATTTATCTTATTTGAAAGTATTAGTTCCATTGTGCCTGGAAACCACAC
TCCTTTAGATTGGGGGCCGAGAGGCGACAACCCAACATTGAGGAGAGTTTATTTTTAAACATGGCTAGTTGTCAGTATGTACGTGAGCTA
GTATTTTTATGAGTCGAGTTTTTTAAAGGCACATTCTGTATACTGCTTAGTATATGCATTTTATACCATGTAATTATAAAACACTCGAGT
AAGTTCAGCATTAGAAATGTTTAGCTTTGTATGAACTGAGTGTGCCAGAAATAAACCTGGAGCAATTTTTAAATAAGCAAAATAAAGGAG
ATTTTTCTATTTGTTCACTTTAATTTATTCACTTTTGTGTACTTTTATGTACTGCAAATCAGATTTCAGTCTAAAGCGAAACATCAGTAA
GTTAATAATAAACCTATCTTTTGGGAAGTTGAATATTAATCTGTACCCAAAACGTATTTAGTAAAATATTTGCCCCCGCCACCCTGCCAT
GCTGACATAACAACTTTTATAATGTTGAATAGATGATATGGGAAATACTAATAACAACAATGTAATTTTTGCAGACAGCTTTAACTTATA
TACATTGCTTGATTTTTTTCAAAAGACTAAATATGTCATTTATACTTTGTTTATTTTCTACCAAAGAAGGTTTGTAAAAATATGCCTGCT
GCTTTTCCTTTTGAAGGACACAAACCTGGTCCCAACATGTGTGGATTTTAACTCTGAGTGGGGTGCATTAAATCAAAAGAGAGAGGCAGA
AGATGAAATGCTAAAGAAGGGTCAGGCAAACTTCTGTTTCAGTATAAAATTCATCATGCAGGCTTCTGAGTGAAATAGAATGATTTGAAA
CCACTACTGTATTGCCTGGATACACACACACACACACACACACACTTTATACAAAAATGTTAAAAGCAGGTTTCCTGGCATGTTCTAAAC
TGTTTTTTCTTTAGGAATAAATTACATTTATCTGCACAGATGTTGAAAATCCTGTTAAACCCTTGTCAAGGATTTGTTTATTTTACATTA

>99475_99475_10_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000566780_C15orf41_chr15_37100525_ENST00000437989_length(amino acids)=237AA_BP=159
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWIWARLSHL

--------------------------------------------------------------
>99475_99475_11_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000566780_C15orf41_chr15_37100525_ENST00000562877_length(transcript)=1012nt_BP=882nt
GTCCTGGCCCGAAACTGGATGCGCACGCCCCTTCCCTGCGGCGGGGAGGCTGACAAGGCTCCGCTCTATCTCTAGCGCCTCGGAGCGCTC
TCCGGCTTTGCTGTCTAGCCCGGCGGCAGCGCGATCTCTTAGGCACTTTCACCGCCTTCCTCTCCAGGCCCTGCCCCTTTGACGCCGGCC
GTCGCGATATTGCGGAGACTGGATTTCAGCTTCGTGGTCGGCGGAGCGGCCCCTGGAGGGCGCAGTGCGCAGGCGTGAGCGGTCGGGCCC
CGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAG
TCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAG
GACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGAT
TTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCA
AGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAG
GGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGT
GCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGATTTGGGCCAGGCTTAGT
CATCTATTGGTATGGATTTATCCAGGAGCTGGACTGCAACCGGGAAAGGGGCATCCTGCTCAAAGCCTGTTTCCCCACGAACATTGTCAC

>99475_99475_11_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000566780_C15orf41_chr15_37100525_ENST00000562877_length(amino acids)=215AA_BP=159
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWIWARLSHL

--------------------------------------------------------------
>99475_99475_12_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000566780_C15orf41_chr15_37100525_ENST00000566621_length(transcript)=2782nt_BP=882nt
GTCCTGGCCCGAAACTGGATGCGCACGCCCCTTCCCTGCGGCGGGGAGGCTGACAAGGCTCCGCTCTATCTCTAGCGCCTCGGAGCGCTC
TCCGGCTTTGCTGTCTAGCCCGGCGGCAGCGCGATCTCTTAGGCACTTTCACCGCCTTCCTCTCCAGGCCCTGCCCCTTTGACGCCGGCC
GTCGCGATATTGCGGAGACTGGATTTCAGCTTCGTGGTCGGCGGAGCGGCCCCTGGAGGGCGCAGTGCGCAGGCGTGAGCGGTCGGGCCC
CGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAG
TCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAG
GACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGAT
TTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCA
AGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAG
GGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGT
GCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGATTTGGGCCAGGCTTAGT
CATCTATTGGTATGGATTTATCCAGGAGCTGGACTGCAACCGGGAAAGGGGCATCCTGCTCAAAGCCTGTTTCCCCACGAACATTGTCAC
CTTATGCCACAGCATAGCTTGACCCTGAAGATCCTGGAAGAGAAGCTGGGAGGAAAAGGTGAATCCGGAAGCAATTTTACTTTCCTGCAC
TGTAAGATCCTGGCAACATCTGCCCTGAACTTCAGCTGAACTCTTGCTGCCCGTAGTCACACCACTACCTCTTTAGACAAACATATCAAG
AGTTTCTGTTTTCCTTCATCCCTTGCTGATGTGAACAGCCAAGAACTACAGACACAACCCACTCATTATCAGCATTTCTGTCTCTGTCAA
ACAATTAGTTTATAGATAGTCATAATCTTTCTTTCTTCCGGATGGTTTATCCTTGTATGCTGAACAAAAGAAAAAATGTGAAGACTGAAA
GGTGTGATTTTTCAATTCTCCTCCCAGTTACCGAATCACCCTCTTATTTTTTTTTCCCTAAGCCTCCGTTCACTGTCTCTCCCTCTCCCT
TTCTCTTCATGTGCACTCACAGAGACCCAGCATTGCATTACCATCGTGGAATAATCTAGCGCAAACCTAGGAAAGCTGAAGCCACAAAGT
CCAAAGCCACCTTTGTACTCACCTGCAGAGCTCCAGAAGACCTTGATGGCAGCCTGCCTATGCTGTGTGTTTGCTATATTCAATCTTTAC
GGCTTCCTGACTTCTGTGACAGTAAGCCAAGTGCAAAAATACACTTGATGAGAATTTCCTCTTTTAATAATGTTATTTGAACACCACATA
TTTTAGATTTATCTTATTTGAAAGTATTAGTTCCATTGTGCCTGGAAACCACACTCCTTTAGATTGGGGGCCGAGAGGCGACAACCCAAC
ATTGAGGAGAGTTTATTTTTAAACATGGCTAGTTGTCAGTATGTACGTGAGCTAGTATTTTTATGAGTCGAGTTTTTTAAAGGCACATTC
TGTATACTGCTTAGTATATGCATTTTATACCATGTAATTATAAAACACTCGAGTAAGTTCAGCATTAGAAATGTTTAGCTTTGTATGAAC
TGAGTGTGCCAGAAATAAACCTGGAGCAATTTTTAAATAAGCAAAATAAAGGAGATTTTTCTATTTGTTCACTTTAATTTATTCACTTTT
GTGTACTTTTATGTACTGCAAATCAGATTTCAGTCTAAAGCGAAACATCAGTAAGTTAATAATAAACCTATCTTTTGGGAAGTTGAATAT
TAATCTGTACCCAAAACGTATTTAGTAAAATATTTGCCCCCGCCACCCTGCCATGCTGACATAACAACTTTTATAATGTTGAATAGATGA
TATGGGAAATACTAATAACAACAATGTAATTTTTGCAGACAGCTTTAACTTATATACATTGCTTGATTTTTTTCAAAAGACTAAATATGT
CATTTATACTTTGTTTATTTTCTACCAAAGAAGGTTTGTAAAAATATGCCTGCTGCTTTTCCTTTTGAAGGACACAAACCTGGTCCCAAC
ATGTGTGGATTTTAACTCTGAGTGGGGTGCATTAAATCAAAAGAGAGAGGCAGAAGATGAAATGCTAAAGAAGGGTCAGGCAAACTTCTG
TTTCAGTATAAAATTCATCATGCAGGCTTCTGAGTGAAATAGAATGATTTGAAACCACTACTGTATTGCCTGGATACACACACACACACA
CACACACACTTTATACAAAAATGTTAAAAGCAGGTTTCCTGGCATGTTCTAAACTGTTTTTTCTTTAGGAATAAATTACATTTATCTGCA

>99475_99475_12_WWOX-C15orf41_WWOX_chr16_78198186_ENST00000566780_C15orf41_chr15_37100525_ENST00000566621_length(amino acids)=250AA_BP=159
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWIWARLSHL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WWOX-C15orf41


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneWWOXchr16:78198186chr15:37100525ENST00000355860+56125_414172.0190.0MAPT
HgeneWWOXchr16:78198186chr15:37100525ENST00000402655+15125_4140312.0MAPT
HgeneWWOXchr16:78198186chr15:37100525ENST00000406884+56125_414172.0235.0MAPT
HgeneWWOXchr16:78198186chr15:37100525ENST00000408984+510125_414172.0311.6666666666667MAPT
HgeneWWOXchr16:78198186chr15:37100525ENST00000566780+59125_414172.0415.0MAPT
HgeneWWOXchr16:78198186chr15:37100525ENST00000569818+11125_414037.0MAPT


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WWOX-C15orf41


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WWOX-C15orf41


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource