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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WWOX-NUDT7 (FusionGDB2 ID:99490)

Fusion Gene Summary for WWOX-NUDT7

check button Fusion gene summary
Fusion gene informationFusion gene name: WWOX-NUDT7
Fusion gene ID: 99490
HgeneTgene
Gene symbol

WWOX

NUDT7

Gene ID

51741

283927

Gene nameWW domain containing oxidoreductasenudix hydrolase 7
SynonymsD16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1-
Cytomap

16q23.1-q23.2

16q23.1

Type of geneprotein-codingprotein-coding
DescriptionWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1peroxisomal coenzyme A diphosphatase NUDT7nudix (nucleoside diphosphate linked moiety X)-type motif 7
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000355860, ENST00000402655, 
ENST00000406884, ENST00000408984, 
ENST00000539474, ENST00000566780, 
ENST00000565791, ENST00000569818, 
ENST00000564031, ENST00000437314, 
ENST00000563839, ENST00000568787, 
ENST00000268533, ENST00000564085, 
Fusion gene scores* DoF score26 X 26 X 8=54081 X 1 X 2=2
# samples 312
** MAII scorelog2(31/5408*10)=-4.12475503100795
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context

PubMed: WWOX [Title/Abstract] AND NUDT7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWWOX(78458952)-NUDT7(77775479), # samples:2
WWOX(78149051)-NUDT7(77775479), # samples:2
Anticipated loss of major functional domain due to fusion event.WWOX-NUDT7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WWOX-NUDT7 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
WWOX-NUDT7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

HgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check buttonFusion gene breakpoints across WWOX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUDT7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-H4-A2HQ-01AWWOXchr16

78458952

+NUDT7chr16

77775479

+
ChimerDB4OVTCGA-24-1842-01AWWOXchr16

78149051

+NUDT7chr16

77775479

+


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Fusion Gene ORF analysis for WWOX-NUDT7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000355860ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000402655ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000406884ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000408984ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000408984ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000539474ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000566780ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-3UTRENST00000566780ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000355860ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000355860ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000355860ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000402655ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000402655ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000402655ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000406884ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000406884ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000406884ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000408984ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-intronENST00000408984ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000408984ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-intronENST00000408984ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000408984ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-intronENST00000408984ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000539474ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000539474ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000539474ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000566780ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-intronENST00000566780ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000566780ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-intronENST00000566780ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
5CDS-intronENST00000566780ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
5CDS-intronENST00000566780ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000355860ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000402655ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000406884ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000408984ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000408984ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
Frame-shiftENST00000539474ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000566780ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
Frame-shiftENST00000566780ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
In-frameENST00000355860ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
In-frameENST00000402655ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
In-frameENST00000406884ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
In-frameENST00000408984ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
In-frameENST00000408984ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
In-frameENST00000539474ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
In-frameENST00000566780ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
In-frameENST00000566780ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-3CDSENST00000355860ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000355860ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000402655ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000402655ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000406884ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000406884ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000539474ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000539474ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000565791ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000565791ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-3CDSENST00000565791ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000565791ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-3CDSENST00000569818ENST00000268533WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000569818ENST00000268533WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-3CDSENST00000569818ENST00000564085WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3CDSENST00000569818ENST00000564085WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-3UTRENST00000355860ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3UTRENST00000402655ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3UTRENST00000406884ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3UTRENST00000539474ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3UTRENST00000565791ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3UTRENST00000565791ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-3UTRENST00000569818ENST00000564031WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-3UTRENST00000569818ENST00000564031WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-intronENST00000355860ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000355860ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000355860ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000402655ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000402655ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000402655ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000406884ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000406884ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000406884ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000539474ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000539474ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000539474ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000565791ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000565791ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-intronENST00000565791ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000565791ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-intronENST00000565791ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000565791ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-intronENST00000569818ENST00000437314WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000569818ENST00000437314WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-intronENST00000569818ENST00000563839WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000569818ENST00000563839WWOXchr16

78149051

+NUDT7chr16

77775479

+
intron-intronENST00000569818ENST00000568787WWOXchr16

78458952

+NUDT7chr16

77775479

+
intron-intronENST00000569818ENST00000568787WWOXchr16

78149051

+NUDT7chr16

77775479

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000566780WWOXchr1678458952+ENST00000268533NUDT7chr1677775479+183611573661169267
ENST00000408984WWOXchr1678458952+ENST00000268533NUDT7chr1677775479+155587685888267
ENST00000566780WWOXchr1678149051+ENST00000564085NUDT7chr1677775479+1163775366845159
ENST00000406884WWOXchr1678149051+ENST00000564085NUDT7chr1677775479+922534125604159
ENST00000539474WWOXchr1678149051+ENST00000564085NUDT7chr1677775479+922534125604159
ENST00000402655WWOXchr1678149051+ENST00000564085NUDT7chr1677775479+922534125604159
ENST00000408984WWOXchr1678149051+ENST00000564085NUDT7chr1677775479+88249485564159
ENST00000355860WWOXchr1678149051+ENST00000564085NUDT7chr1677775479+897509100579159

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000566780ENST00000268533WWOXchr1678458952+NUDT7chr1677775479+0.003803490.9961965
ENST00000408984ENST00000268533WWOXchr1678458952+NUDT7chr1677775479+0.0018954810.99810445
ENST00000566780ENST00000564085WWOXchr1678149051+NUDT7chr1677775479+0.0079093040.9920907
ENST00000406884ENST00000564085WWOXchr1678149051+NUDT7chr1677775479+0.0064471770.9935528
ENST00000539474ENST00000564085WWOXchr1678149051+NUDT7chr1677775479+0.0064471770.9935528
ENST00000402655ENST00000564085WWOXchr1678149051+NUDT7chr1677775479+0.0064471770.9935528
ENST00000408984ENST00000564085WWOXchr1678149051+NUDT7chr1677775479+0.0046970280.99530303
ENST00000355860ENST00000564085WWOXchr1678149051+NUDT7chr1677775479+0.0047552090.9952448

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Fusion Genomic Features for WWOX-NUDT7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WWOXchr1678458952+NUDT7chr1677775478+6.95E-080.9999999
WWOXchr1678149051+NUDT7chr1677775478+1.82E-111
WWOXchr1678458952+NUDT7chr1677775478+6.95E-080.9999999
WWOXchr1678149051+NUDT7chr1677775478+1.82E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for WWOX-NUDT7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:78458952/chr16:77775479)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWOXchr16:78149051chr16:77775479ENST00000355860+4616_49136190.0DomainWW 1
HgeneWWOXchr16:78149051chr16:77775479ENST00000355860+4657_90136190.0DomainWW 2
HgeneWWOXchr16:78149051chr16:77775479ENST00000402655+4516_49136312.0DomainWW 1
HgeneWWOXchr16:78149051chr16:77775479ENST00000402655+4557_90136312.0DomainWW 2
HgeneWWOXchr16:78149051chr16:77775479ENST00000406884+4616_49136235.0DomainWW 1
HgeneWWOXchr16:78149051chr16:77775479ENST00000406884+4657_90136235.0DomainWW 2
HgeneWWOXchr16:78149051chr16:77775479ENST00000408984+41016_49136311.6666666666667DomainWW 1
HgeneWWOXchr16:78149051chr16:77775479ENST00000408984+41057_90136311.6666666666667DomainWW 2
HgeneWWOXchr16:78149051chr16:77775479ENST00000566780+4916_49136415.0DomainWW 1
HgeneWWOXchr16:78149051chr16:77775479ENST00000566780+4957_90136415.0DomainWW 2
HgeneWWOXchr16:78458952chr16:77775479ENST00000408984+71016_49263311.6666666666667DomainWW 1
HgeneWWOXchr16:78458952chr16:77775479ENST00000408984+71057_90263311.6666666666667DomainWW 2
HgeneWWOXchr16:78458952chr16:77775479ENST00000566780+7916_49263415.0DomainWW 1
HgeneWWOXchr16:78458952chr16:77775479ENST00000566780+7957_90263415.0DomainWW 2
HgeneWWOXchr16:78149051chr16:77775479ENST00000355860+4650_55136190.0MotifNuclear localization signal
HgeneWWOXchr16:78149051chr16:77775479ENST00000402655+4550_55136312.0MotifNuclear localization signal
HgeneWWOXchr16:78149051chr16:77775479ENST00000406884+4650_55136235.0MotifNuclear localization signal
HgeneWWOXchr16:78149051chr16:77775479ENST00000408984+41050_55136311.6666666666667MotifNuclear localization signal
HgeneWWOXchr16:78149051chr16:77775479ENST00000566780+4950_55136415.0MotifNuclear localization signal
HgeneWWOXchr16:78458952chr16:77775479ENST00000408984+71050_55263311.6666666666667MotifNuclear localization signal
HgeneWWOXchr16:78458952chr16:77775479ENST00000566780+7950_55263415.0MotifNuclear localization signal
HgeneWWOXchr16:78149051chr16:77775479ENST00000355860+46131_137136190.0Nucleotide bindingNADP
HgeneWWOXchr16:78149051chr16:77775479ENST00000402655+45131_137136312.0Nucleotide bindingNADP
HgeneWWOXchr16:78149051chr16:77775479ENST00000406884+46131_137136235.0Nucleotide bindingNADP
HgeneWWOXchr16:78149051chr16:77775479ENST00000408984+410131_137136311.6666666666667Nucleotide bindingNADP
HgeneWWOXchr16:78149051chr16:77775479ENST00000566780+49131_137136415.0Nucleotide bindingNADP
HgeneWWOXchr16:78458952chr16:77775479ENST00000408984+710131_137263311.6666666666667Nucleotide bindingNADP
HgeneWWOXchr16:78458952chr16:77775479ENST00000566780+79131_137263415.0Nucleotide bindingNADP
TgeneNUDT7chr16:78149051chr16:77775479ENST0000026853324236_238116239.0MotifMicrobody targeting signal
TgeneNUDT7chr16:78149051chr16:77775479ENST0000043731413236_23863186.0MotifMicrobody targeting signal
TgeneNUDT7chr16:78149051chr16:77775479ENST000004373141377_9863186.0MotifNote=Nudix box
TgeneNUDT7chr16:78458952chr16:77775479ENST0000026853324236_238116239.0MotifMicrobody targeting signal
TgeneNUDT7chr16:78458952chr16:77775479ENST0000043731413236_23863186.0MotifMicrobody targeting signal
TgeneNUDT7chr16:78458952chr16:77775479ENST000004373141377_9863186.0MotifNote=Nudix box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWOXchr16:78149051chr16:77775479ENST00000569818+1116_49037.0DomainWW 1
HgeneWWOXchr16:78149051chr16:77775479ENST00000569818+1157_90037.0DomainWW 2
HgeneWWOXchr16:78458952chr16:77775479ENST00000355860+1616_490190.0DomainWW 1
HgeneWWOXchr16:78458952chr16:77775479ENST00000355860+1657_900190.0DomainWW 2
HgeneWWOXchr16:78458952chr16:77775479ENST00000402655+1516_490312.0DomainWW 1
HgeneWWOXchr16:78458952chr16:77775479ENST00000402655+1557_900312.0DomainWW 2
HgeneWWOXchr16:78458952chr16:77775479ENST00000406884+1616_490235.0DomainWW 1
HgeneWWOXchr16:78458952chr16:77775479ENST00000406884+1657_900235.0DomainWW 2
HgeneWWOXchr16:78458952chr16:77775479ENST00000569818+1116_49037.0DomainWW 1
HgeneWWOXchr16:78458952chr16:77775479ENST00000569818+1157_90037.0DomainWW 2
HgeneWWOXchr16:78149051chr16:77775479ENST00000569818+1150_55037.0MotifNuclear localization signal
HgeneWWOXchr16:78458952chr16:77775479ENST00000355860+1650_550190.0MotifNuclear localization signal
HgeneWWOXchr16:78458952chr16:77775479ENST00000402655+1550_550312.0MotifNuclear localization signal
HgeneWWOXchr16:78458952chr16:77775479ENST00000406884+1650_550235.0MotifNuclear localization signal
HgeneWWOXchr16:78458952chr16:77775479ENST00000569818+1150_55037.0MotifNuclear localization signal
HgeneWWOXchr16:78149051chr16:77775479ENST00000569818+11131_137037.0Nucleotide bindingNADP
HgeneWWOXchr16:78458952chr16:77775479ENST00000355860+16131_1370190.0Nucleotide bindingNADP
HgeneWWOXchr16:78458952chr16:77775479ENST00000402655+15131_1370312.0Nucleotide bindingNADP
HgeneWWOXchr16:78458952chr16:77775479ENST00000406884+16131_1370235.0Nucleotide bindingNADP
HgeneWWOXchr16:78458952chr16:77775479ENST00000569818+11131_137037.0Nucleotide bindingNADP
HgeneWWOXchr16:78149051chr16:77775479ENST00000355860+46209_273136190.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78149051chr16:77775479ENST00000402655+45209_273136312.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78149051chr16:77775479ENST00000406884+46209_273136235.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78149051chr16:77775479ENST00000408984+410209_273136311.6666666666667RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78149051chr16:77775479ENST00000566780+49209_273136415.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78149051chr16:77775479ENST00000569818+11209_273037.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78458952chr16:77775479ENST00000355860+16209_2730190.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78458952chr16:77775479ENST00000402655+15209_2730312.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78458952chr16:77775479ENST00000406884+16209_2730235.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78458952chr16:77775479ENST00000408984+710209_273263311.6666666666667RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78458952chr16:77775479ENST00000566780+79209_273263415.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78458952chr16:77775479ENST00000569818+11209_273037.0RegionMediates targeting to the mitochondria
TgeneNUDT7chr16:78149051chr16:77775479ENST000002685332437_172116239.0DomainNudix hydrolase
TgeneNUDT7chr16:78149051chr16:77775479ENST000004373141337_17263186.0DomainNudix hydrolase
TgeneNUDT7chr16:78458952chr16:77775479ENST000002685332437_172116239.0DomainNudix hydrolase
TgeneNUDT7chr16:78458952chr16:77775479ENST000004373141337_17263186.0DomainNudix hydrolase
TgeneNUDT7chr16:78149051chr16:77775479ENST000002685332477_98116239.0MotifNote=Nudix box
TgeneNUDT7chr16:78458952chr16:77775479ENST000002685332477_98116239.0MotifNote=Nudix box


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Fusion Gene Sequence for WWOX-NUDT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99490_99490_1_WWOX-NUDT7_WWOX_chr16_78149051_ENST00000355860_NUDT7_chr16_77775479_ENST00000564085_length(transcript)=897nt_BP=509nt
GCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCC
ACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCAC
CAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGG
AGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGA
CCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCT
CCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGATACATTGATAACTCCATTTGTGGGTT
TAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCTCTGGCCTATTTCCTGCATCCACAGG
TCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACAAACCCTGAAGACGGTGTCACTTACC
AGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCCACCTTTGAGGTTCAATTTAATCTTA

>99490_99490_1_WWOX-NUDT7_WWOX_chr16_78149051_ENST00000355860_NUDT7_chr16_77775479_ENST00000564085_length(amino acids)=159AA_BP=136
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL

--------------------------------------------------------------
>99490_99490_2_WWOX-NUDT7_WWOX_chr16_78149051_ENST00000402655_NUDT7_chr16_77775479_ENST00000564085_length(transcript)=922nt_BP=534nt
GCAGTGCGCAGGCGTGAGCGGTCGGGCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCG
GGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGC
CTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAA
CTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATA
TAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACG
GCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGAT
ACATTGATAACTCCATTTGTGGGTTTAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCT
CTGGCCTATTTCCTGCATCCACAGGTCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACA
AACCCTGAAGACGGTGTCACTTACCAGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCC
ACCTTTGAGGTTCAATTTAATCTTAATGATGTATTAGCATCCTCTGAAGAGTTATTCCTGAAGGTTCATAAAAAAGCTACAAGCAGGTTA

>99490_99490_2_WWOX-NUDT7_WWOX_chr16_78149051_ENST00000402655_NUDT7_chr16_77775479_ENST00000564085_length(amino acids)=159AA_BP=136
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL

--------------------------------------------------------------
>99490_99490_3_WWOX-NUDT7_WWOX_chr16_78149051_ENST00000406884_NUDT7_chr16_77775479_ENST00000564085_length(transcript)=922nt_BP=534nt
GCAGTGCGCAGGCGTGAGCGGTCGGGCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCG
GGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGC
CTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAA
CTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATA
TAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACG
GCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGAT
ACATTGATAACTCCATTTGTGGGTTTAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCT
CTGGCCTATTTCCTGCATCCACAGGTCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACA
AACCCTGAAGACGGTGTCACTTACCAGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCC
ACCTTTGAGGTTCAATTTAATCTTAATGATGTATTAGCATCCTCTGAAGAGTTATTCCTGAAGGTTCATAAAAAAGCTACAAGCAGGTTA

>99490_99490_3_WWOX-NUDT7_WWOX_chr16_78149051_ENST00000406884_NUDT7_chr16_77775479_ENST00000564085_length(amino acids)=159AA_BP=136
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL

--------------------------------------------------------------
>99490_99490_4_WWOX-NUDT7_WWOX_chr16_78149051_ENST00000408984_NUDT7_chr16_77775479_ENST00000564085_length(transcript)=882nt_BP=494nt
GGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGC
AGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGT
TTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGG
ATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTT
TACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTT
CACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGATACATTGATAACTCCATTTGTGGGTTTAATAGACCACAACT
TCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCTCTGGCCTATTTCCTGCATCCACAGGTCCATGACCAGCATT
ACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACAAACCCTGAAGACGGTGTCACTTACCAGATCAAGGGAATGA
CGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCCACCTTTGAGGTTCAATTTAATCTTAATGATGTATTAGCAT

>99490_99490_4_WWOX-NUDT7_WWOX_chr16_78149051_ENST00000408984_NUDT7_chr16_77775479_ENST00000564085_length(amino acids)=159AA_BP=136
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL

--------------------------------------------------------------
>99490_99490_5_WWOX-NUDT7_WWOX_chr16_78149051_ENST00000539474_NUDT7_chr16_77775479_ENST00000564085_length(transcript)=922nt_BP=534nt
GCAGTGCGCAGGCGTGAGCGGTCGGGCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCG
GGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGC
CTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAA
CTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATA
TAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACG
GCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGAT
ACATTGATAACTCCATTTGTGGGTTTAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCT
CTGGCCTATTTCCTGCATCCACAGGTCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACA
AACCCTGAAGACGGTGTCACTTACCAGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCC
ACCTTTGAGGTTCAATTTAATCTTAATGATGTATTAGCATCCTCTGAAGAGTTATTCCTGAAGGTTCATAAAAAAGCTACAAGCAGGTTA

>99490_99490_5_WWOX-NUDT7_WWOX_chr16_78149051_ENST00000539474_NUDT7_chr16_77775479_ENST00000564085_length(amino acids)=159AA_BP=136
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL

--------------------------------------------------------------
>99490_99490_6_WWOX-NUDT7_WWOX_chr16_78149051_ENST00000566780_NUDT7_chr16_77775479_ENST00000564085_length(transcript)=1163nt_BP=775nt
GTCCTGGCCCGAAACTGGATGCGCACGCCCCTTCCCTGCGGCGGGGAGGCTGACAAGGCTCCGCTCTATCTCTAGCGCCTCGGAGCGCTC
TCCGGCTTTGCTGTCTAGCCCGGCGGCAGCGCGATCTCTTAGGCACTTTCACCGCCTTCCTCTCCAGGCCCTGCCCCTTTGACGCCGGCC
GTCGCGATATTGCGGAGACTGGATTTCAGCTTCGTGGTCGGCGGAGCGGCCCCTGGAGGGCGCAGTGCGCAGGCGTGAGCGGTCGGGCCC
CGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAG
TCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAG
GACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGAT
TTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCA
AGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAG
GGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGACAGATACATTGATAACTCCATTTGTGGGTTTAAT
AGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCTCTGGCCTATTTCCTGCATCCACAGGTCCA
TGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACAAACCCTGAAGACGGTGTCACTTACCAGAT
CAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCCACCTTTGAGGTTCAATTTAATCTTAATGA

>99490_99490_6_WWOX-NUDT7_WWOX_chr16_78149051_ENST00000566780_NUDT7_chr16_77775479_ENST00000564085_length(amino acids)=159AA_BP=136
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL

--------------------------------------------------------------
>99490_99490_7_WWOX-NUDT7_WWOX_chr16_78458952_ENST00000408984_NUDT7_chr16_77775479_ENST00000268533_length(transcript)=1555nt_BP=876nt
GGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGC
AGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGT
TTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGG
ATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTT
TACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTT
CACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGTGCACATGTGAT
CTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGCATAAAGCCAAGGTAGAAGCAATGACCCT
GGACCTCGCTCTGCTCCGTAGCGTGCAGCATTTTGCTGAAGCATTCAAGGCCAAGAATGTGCCTCTTCATGTGCTTGTGTGCAACGCAGC
AACTTTTGCTCTACCCTGGAGTCTCACCAAAGATGGCCTGGAGACCACCTTTCAAGTGAATCATCTGGGGCACTTCTACCTTGTCCAGCT
CCTCCAGGATGTTTTGTGCCGCTCAGCTCCTGCCCGTGTCATTGTGGTCTCCTCAGAGTCCCATCGACAGATACATTGATAACTCCATTT
GTGGGTTTAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCTCTGGCCTATTTCCTGCAT
CCACAGGTCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACAAACCCTGAAGACGGTGTC
ACTTACCAGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCCACCTTTGAGGTTCAATTT
AATCTTAATGATGTATTAGCATCCTCTGAAGAGTTATTCCTGAAGGTTCATAAAAAAGCTACAAGCAGGTTATGATTTACTAGAGCAAGA
GACAAAGAACTATTCACGAGGATTCTGTGTGTGCTTATTCGTAGAACAACAACAATGCCAGCTGTTGGAATTTGACAGGTGTGAATATTT
TTTCTGCAGTATGTAGTTAGAATCCTTGCCTCTTTTCCAGTTGCCTTCTATTGTCTGAAAAAGTAAAAGCCATTCAAAAATGAAAACTAT
GTTCATAGTGTTGCATATTTTCACCCACAATATGTTAATAATATTTTTCTTACACATATAATAAAGAATATCTGGCACATACTAGGCCCT

>99490_99490_7_WWOX-NUDT7_WWOX_chr16_78458952_ENST00000408984_NUDT7_chr16_77775479_ENST00000268533_length(amino acids)=267AA_BP=
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAM

--------------------------------------------------------------
>99490_99490_8_WWOX-NUDT7_WWOX_chr16_78458952_ENST00000566780_NUDT7_chr16_77775479_ENST00000268533_length(transcript)=1836nt_BP=1157nt
GTCCTGGCCCGAAACTGGATGCGCACGCCCCTTCCCTGCGGCGGGGAGGCTGACAAGGCTCCGCTCTATCTCTAGCGCCTCGGAGCGCTC
TCCGGCTTTGCTGTCTAGCCCGGCGGCAGCGCGATCTCTTAGGCACTTTCACCGCCTTCCTCTCCAGGCCCTGCCCCTTTGACGCCGGCC
GTCGCGATATTGCGGAGACTGGATTTCAGCTTCGTGGTCGGCGGAGCGGCCCCTGGAGGGCGCAGTGCGCAGGCGTGAGCGGTCGGGCCC
CGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAG
TCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAG
GACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGAT
TTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCA
AGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAG
GGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGT
GCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGCATAAAGCCAAGGTAGAA
GCAATGACCCTGGACCTCGCTCTGCTCCGTAGCGTGCAGCATTTTGCTGAAGCATTCAAGGCCAAGAATGTGCCTCTTCATGTGCTTGTG
TGCAACGCAGCAACTTTTGCTCTACCCTGGAGTCTCACCAAAGATGGCCTGGAGACCACCTTTCAAGTGAATCATCTGGGGCACTTCTAC
CTTGTCCAGCTCCTCCAGGATGTTTTGTGCCGCTCAGCTCCTGCCCGTGTCATTGTGGTCTCCTCAGAGTCCCATCGACAGATACATTGA
TAACTCCATTTGTGGGTTTAATAGACCACAACTTCCAGGCCCAGCCGAATCCTGCTGAAGTTAAGGATGTATTCCTGGTGCCTCTGGCCT
ATTTCCTGCATCCACAGGTCCATGACCAGCATTACGTCACACGTCTTGGTCACCGTTTTATTAATCATATCTTTGAGTACACAAACCCTG
AAGACGGTGTCACTTACCAGATCAAGGGAATGACGGCAAACCTTGCAGTGTTGGTGGCCTTTATCATTTTGGAAAAAAAACCCACCTTTG
AGGTTCAATTTAATCTTAATGATGTATTAGCATCCTCTGAAGAGTTATTCCTGAAGGTTCATAAAAAAGCTACAAGCAGGTTATGATTTA
CTAGAGCAAGAGACAAAGAACTATTCACGAGGATTCTGTGTGTGCTTATTCGTAGAACAACAACAATGCCAGCTGTTGGAATTTGACAGG
TGTGAATATTTTTTCTGCAGTATGTAGTTAGAATCCTTGCCTCTTTTCCAGTTGCCTTCTATTGTCTGAAAAAGTAAAAGCCATTCAAAA
ATGAAAACTATGTTCATAGTGTTGCATATTTTCACCCACAATATGTTAATAATATTTTTCTTACACATATAATAAAGAATATCTGGCACA

>99490_99490_8_WWOX-NUDT7_WWOX_chr16_78458952_ENST00000566780_NUDT7_chr16_77775479_ENST00000268533_length(amino acids)=267AA_BP=
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAM

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Fusion Gene PPI Analysis for WWOX-NUDT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneWWOXchr16:78149051chr16:77775479ENST00000355860+46125_414136.33333333333334190.0MAPT
HgeneWWOXchr16:78149051chr16:77775479ENST00000402655+45125_414136.33333333333334312.0MAPT
HgeneWWOXchr16:78149051chr16:77775479ENST00000406884+46125_414136.33333333333334235.0MAPT
HgeneWWOXchr16:78149051chr16:77775479ENST00000408984+410125_414136.33333333333334311.6666666666667MAPT
HgeneWWOXchr16:78149051chr16:77775479ENST00000566780+49125_414136.33333333333334415.0MAPT
HgeneWWOXchr16:78149051chr16:77775479ENST00000569818+11125_414037.0MAPT
HgeneWWOXchr16:78458952chr16:77775479ENST00000355860+16125_4140190.0MAPT
HgeneWWOXchr16:78458952chr16:77775479ENST00000402655+15125_4140312.0MAPT
HgeneWWOXchr16:78458952chr16:77775479ENST00000406884+16125_4140235.0MAPT
HgeneWWOXchr16:78458952chr16:77775479ENST00000408984+710125_414263.6666666666667311.6666666666667MAPT
HgeneWWOXchr16:78458952chr16:77775479ENST00000566780+79125_414263.6666666666667415.0MAPT
HgeneWWOXchr16:78458952chr16:77775479ENST00000569818+11125_414037.0MAPT


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WWOX-NUDT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WWOX-NUDT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource