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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WWOX-RTF1 (FusionGDB2 ID:99495)

Fusion Gene Summary for WWOX-RTF1

check button Fusion gene summary
Fusion gene informationFusion gene name: WWOX-RTF1
Fusion gene ID: 99495
HgeneTgene
Gene symbol

WWOX

RTF1

Gene ID

51741

23168

Gene nameWW domain containing oxidoreductaseRTF1 homolog, Paf1/RNA polymerase II complex component
SynonymsD16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1GTL7|KIAA0252
Cytomap

16q23.1-q23.2

15q15.1

Type of geneprotein-codingprotein-coding
DescriptionWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1RNA polymerase-associated protein RTF1 homologRtf1, Paf1/RNA polymerase II complex component, homologortholog of mouse gene trap locus 7
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000565791, ENST00000355860, 
ENST00000406884, ENST00000408984, 
ENST00000566780, ENST00000402655, 
ENST00000539474, ENST00000569818, 
ENST00000389629, ENST00000462276, 
Fusion gene scores* DoF score26 X 26 X 8=540814 X 10 X 5=700
# samples 3115
** MAII scorelog2(31/5408*10)=-4.12475503100795
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/700*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WWOX [Title/Abstract] AND RTF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWWOX(78198186)-RTF1(41745099), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

HgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691

TgeneRTF1

GO:0019827

stem cell population maintenance

19345177

TgeneRTF1

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

20178742

TgeneRTF1

GO:0045944

positive regulation of transcription by RNA polymerase II

20178742


check buttonFusion gene breakpoints across WWOX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RTF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5803-01AWWOXchr16

78198186

+RTF1chr15

41745099

+


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Fusion Gene ORF analysis for WWOX-RTF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000565791ENST00000389629WWOXchr16

78198186

+RTF1chr15

41745099

+
3UTR-3UTRENST00000565791ENST00000462276WWOXchr16

78198186

+RTF1chr15

41745099

+
5CDS-3UTRENST00000355860ENST00000462276WWOXchr16

78198186

+RTF1chr15

41745099

+
5CDS-3UTRENST00000406884ENST00000462276WWOXchr16

78198186

+RTF1chr15

41745099

+
5CDS-3UTRENST00000408984ENST00000462276WWOXchr16

78198186

+RTF1chr15

41745099

+
5CDS-3UTRENST00000566780ENST00000462276WWOXchr16

78198186

+RTF1chr15

41745099

+
In-frameENST00000355860ENST00000389629WWOXchr16

78198186

+RTF1chr15

41745099

+
In-frameENST00000406884ENST00000389629WWOXchr16

78198186

+RTF1chr15

41745099

+
In-frameENST00000408984ENST00000389629WWOXchr16

78198186

+RTF1chr15

41745099

+
In-frameENST00000566780ENST00000389629WWOXchr16

78198186

+RTF1chr15

41745099

+
intron-3CDSENST00000402655ENST00000389629WWOXchr16

78198186

+RTF1chr15

41745099

+
intron-3CDSENST00000539474ENST00000389629WWOXchr16

78198186

+RTF1chr15

41745099

+
intron-3CDSENST00000569818ENST00000389629WWOXchr16

78198186

+RTF1chr15

41745099

+
intron-3UTRENST00000402655ENST00000462276WWOXchr16

78198186

+RTF1chr15

41745099

+
intron-3UTRENST00000539474ENST00000462276WWOXchr16

78198186

+RTF1chr15

41745099

+
intron-3UTRENST00000569818ENST00000462276WWOXchr16

78198186

+RTF1chr15

41745099

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000566780WWOXchr1678198186+ENST00000389629RTF1chr1541745099+55828823662705779
ENST00000406884WWOXchr1678198186+ENST00000389629RTF1chr1541745099+53416411252464779
ENST00000408984WWOXchr1678198186+ENST00000389629RTF1chr1541745099+5301601852424779
ENST00000355860WWOXchr1678198186+ENST00000389629RTF1chr1541745099+53166161002439779

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000566780ENST00000389629WWOXchr1678198186+RTF1chr1541745099+0.0008787690.99912125
ENST00000406884ENST00000389629WWOXchr1678198186+RTF1chr1541745099+0.0007938730.9992061
ENST00000408984ENST00000389629WWOXchr1678198186+RTF1chr1541745099+0.0007988270.99920124
ENST00000355860ENST00000389629WWOXchr1678198186+RTF1chr1541745099+0.0007803010.99921966

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Fusion Genomic Features for WWOX-RTF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WWOXchr1678198186+RTF1chr1541745098+2.47E-050.9999752
WWOXchr1678198186+RTF1chr1541745098+2.47E-050.9999752

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for WWOX-RTF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:78198186/chr15:41745099)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWOXchr16:78198186chr15:41745099ENST00000355860+5616_49172190.0DomainWW 1
HgeneWWOXchr16:78198186chr15:41745099ENST00000355860+5657_90172190.0DomainWW 2
HgeneWWOXchr16:78198186chr15:41745099ENST00000406884+5616_49172235.0DomainWW 1
HgeneWWOXchr16:78198186chr15:41745099ENST00000406884+5657_90172235.0DomainWW 2
HgeneWWOXchr16:78198186chr15:41745099ENST00000408984+51016_49172311.6666666666667DomainWW 1
HgeneWWOXchr16:78198186chr15:41745099ENST00000408984+51057_90172311.6666666666667DomainWW 2
HgeneWWOXchr16:78198186chr15:41745099ENST00000566780+5916_49172415.0DomainWW 1
HgeneWWOXchr16:78198186chr15:41745099ENST00000566780+5957_90172415.0DomainWW 2
HgeneWWOXchr16:78198186chr15:41745099ENST00000355860+5650_55172190.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr15:41745099ENST00000406884+5650_55172235.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr15:41745099ENST00000408984+51050_55172311.6666666666667MotifNuclear localization signal
HgeneWWOXchr16:78198186chr15:41745099ENST00000566780+5950_55172415.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr15:41745099ENST00000355860+56131_137172190.0Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr15:41745099ENST00000406884+56131_137172235.0Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr15:41745099ENST00000408984+510131_137172311.6666666666667Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr15:41745099ENST00000566780+59131_137172415.0Nucleotide bindingNADP
TgeneRTF1chr16:78198186chr15:41745099ENST00000389629118526_560103711.0Coiled coilOntology_term=ECO:0000255
TgeneRTF1chr16:78198186chr15:41745099ENST00000389629118135_173103711.0Compositional biasNote=Ser-rich
TgeneRTF1chr16:78198186chr15:41745099ENST00000389629118174_345103711.0Compositional biasNote=Glu-rich
TgeneRTF1chr16:78198186chr15:41745099ENST00000389629118214_307103711.0Compositional biasNote=Lys-rich
TgeneRTF1chr16:78198186chr15:41745099ENST00000389629118353_484103711.0DomainPlus3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWOXchr16:78198186chr15:41745099ENST00000402655+1516_490312.0DomainWW 1
HgeneWWOXchr16:78198186chr15:41745099ENST00000402655+1557_900312.0DomainWW 2
HgeneWWOXchr16:78198186chr15:41745099ENST00000569818+1116_49037.0DomainWW 1
HgeneWWOXchr16:78198186chr15:41745099ENST00000569818+1157_90037.0DomainWW 2
HgeneWWOXchr16:78198186chr15:41745099ENST00000402655+1550_550312.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr15:41745099ENST00000569818+1150_55037.0MotifNuclear localization signal
HgeneWWOXchr16:78198186chr15:41745099ENST00000402655+15131_1370312.0Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr15:41745099ENST00000569818+11131_137037.0Nucleotide bindingNADP
HgeneWWOXchr16:78198186chr15:41745099ENST00000355860+56209_273172190.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr15:41745099ENST00000402655+15209_2730312.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr15:41745099ENST00000406884+56209_273172235.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr15:41745099ENST00000408984+510209_273172311.6666666666667RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr15:41745099ENST00000566780+59209_273172415.0RegionMediates targeting to the mitochondria
HgeneWWOXchr16:78198186chr15:41745099ENST00000569818+11209_273037.0RegionMediates targeting to the mitochondria
TgeneRTF1chr16:78198186chr15:41745099ENST0000038962911810_18103711.0Compositional biasNote=Poly-Ala


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Fusion Gene Sequence for WWOX-RTF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99495_99495_1_WWOX-RTF1_WWOX_chr16_78198186_ENST00000355860_RTF1_chr15_41745099_ENST00000389629_length(transcript)=5316nt_BP=616nt
GCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCC
ACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCAC
CAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGG
AGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGA
CCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCT
CCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCA
TGGTGCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGTGGACATTTGGGAG
CAATAAAAATAAGAAGAAAGGAAAAGCCAGAAAAATAGAGAAGAAAGGAACCATGAAGAAACAGGCCAACAAAACTGCCTCCTCAGGCAG
TTCAGACAAAGACAGTTCAGCTGAGAGCTCAGCCCCTGAGGAAGGTGAAGTGTCAGACTCTGACAGCAACAGCTCCTCTTCCAGTTCAGA
TTCAGACTCTTCCTCAGAAGATGAAGAGTTCCATGATGGCTATGGAGAAGACCTCATGGGAGATGAGGAAGACAGGGCCCGTCTGGAACA
GATGACAGAGAAAGAGAGAGAGCAAGAACTGTTCAATCGCATAGAGAAGAGGGAGGTGTTGAAAAGAAGATTTGAAATCAAGAAAAAACT
AAAAACAGCCAAAAAGAAAGAAAAGAAAGAAAAGAAGAAAAAGCAAGAAGAGGAGCAAGAAAAGAAAAAACTGACACAGATTCAAGAATC
TCAGGTAACATCCCACAACAAGGAACGGCGTTCCAAGCGGGATGAGAAACTAGACAAGAAATCTCAAGCCATGGAGGAGCTAAAAGCAGA
GCGAGAAAAACGAAAGAACAGAACAGCTGAGCTCCTTGCCAAAAAACAGCCATTAAAAACCAGTGAGGTCTACTCTGATGATGAAGAGGA
GGAAGAGGATGACAAATCCAGTGAAAAGTCAGACCGCTCATCACGAACATCATCGTCTGATGAAGAAGAGGAGAAAGAAGAGATCCCTCC
CAAATCCCAACCAGTTTCCTTACCTGAAGAATTGAATCGGGTTCGATTATCACGGCATAAGCTAGAACGCTGGTGTCACATGCCCTTCTT
TGCTAAAACTGTCACAGGATGTTTTGTGCGGATTGGCATCGGAAACCACAACAGCAAACCAGTTTACCGGGTCGCTGAGATTACGGGTGT
TGTGGAAACTGCCAAAGTTTACCAACTAGGTGGCACCAGAACAAACAAAGGGCTGCAACTACGGCATGGCAATGACCAACGCGTGTTCCG
TTTAGAGTTTGTCTCAAACCAAGAATTCACCGAAAGTGAGTTTATGAAGTGGAAAGAAGCGATGTTCTCTGCTGGCATGCAGTTGCCCAC
TCTAGATGAAATCAATAAAAAGGAATTATCTATTAAAGAAGCTCTTAATTATAAATTCAATGATCAGGACATTGAAGAGATTGTAAAAGA
GAAAGAAAGGTTCAGAAAAGCTCCACCCAACTACGCTATGAAGAAGACTCAGCTACTGAAGGAAAAGGCCATGGCTGAGGACCTGGGGGA
TCAGGACAAGGCCAAACAAATCCAAGATCAACTGAATGAGCTGGAGGAACGGGCAGAGGCCCTGGACCGCCAGCGGACCAAGAACATATC
CGCTATCAGTTACATCAACCAGCGGAACCGGGAGTGGAACATTGTAGAGTCTGAGAAGGCCCTTGTGGCTGAAAGTCACAACATGAAAAA
CCAACAGATGGATCCCTTTACTCGGCGGCAGTGCAAGCCTACCATCGTTTCTAATTCCAGAGACCCAGCTGTTCAAGCTGCCATCTTGGC
CCAGCTGAATGCAAAATACGGTTCTGGAGTGTTACCAGATGCTCCAAAGGAAATGAGCAAGGGTCAAGGCAAAGATAAAGATTTGAATTC
TAAGTCAGCCAGTGACCTCTCAGAAGATCTGTTCAAAGTACACGATTTTGATGTGAAGATTGACTTACAAGTTCCCAGCTCAGAGTCAAA
GGCTTTAGCCATCACCTCCAAGGCTCCGCCAGCCAAGGATGGGGCTCCAAGGAGATCTCTGAACTTGGAAGACTACAAAAAACGACGAGG
GCTTATTTGAGCACACCCAGCCTGCTGCTTCTGACCCTGCATGCCCCATCGCAGCGTCCCACCTTTCCTCCTTTCCTTTGATTTAGCCTC
TTTGGGCTGGAGCAGCTGTTGAACTGGGAAGAGACTCTAAACTGCCAGTCATCTGTAATATAAACCATTTGCTGTATAGACCTCCTTTGT
CTGCACACCATCTCCCACCAGCCTCCCCTCCCCCAGGGCCCCACCCAGTGTGGGCCTGGGCTCTCTTGGGCTTTATCCATGTCTTTAGAT
TTGTGTTTGCCTTTTGTTTTTTTAACCGCGCAGTTCATTGGCCACTCTGCACGCATTCAGTATTACCATGGAGCTGGGAATCTTGCTGGA
GCCCCTGGGGCAATAGCAGCAGCACCAGGCGGTCTCCTCTACAGACTGCCTTGGCCCACCCATTGAACATTCGGCACGTGACCTTGTGGG
GGGAGCGGGGATTGGGCACCTGCGATCCTCTTTCCTCTCTTCATCTTTCTCTTCTGCCCTTCTTTTTGGAAGAAGGGGTTTCAAAACCAG
TTTAGTTTCCAAAAAGTGTACATTTGTGGGGGGGGGGGGTCTAATTTGAGAGCGAGAGTGTGTATGTGTGTGTGTGTAAGTGTGTGGATT
TTTTTATCATTTTTTTAAAATGCAGTACTCTTTGTATCAGTCTGTCATGGGTCTATAGCTGTTTCAGATTTTTTTCAGCTGTACTTGAGC
ATCTGAAACTGCAAGAAAGAAACTCATTAAATGTGATTCTTCTTACTAAACAGGCCTGACTGCTGTAGCTGTGTAACTTCCCCATTCCCA
CCTACTCTTCCCATCCTTTCCCAACTTTGGAGAAAACTCCCCAGTTTAGCCCCCTGACCTGCAGGCTGTGTCCTGGCAGGTGTGGGAGGG
AAGCCCATGGCCAGGTACCAGGGAGGGCAGTGAATGTCTTGCTCTTCCCATGGGTACAGCCCACAGCTTCTTGGCTGAACGTAGAACTTC
TTTTTCTCACCCAGTATACCAGCCTCTTCCTGGTGATTCTGTTTTGCTGCTTTGGCAAGAACTACATTTTGTTTTTAAGAGAAATTTCTG
AATATGAATGTGGAGAGCAAACACAAAAAGATTTAGGTTACGCCGGGTGCAGTAGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCTA
GGCGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAATCTGACTAACACGGTGAAACCCCATCTCTACTAAAACTACAAAACTTAGCCG
GGCATGGTGGTGCGTGCCTGTAATCCCAGCTACTCGGGGGGCTGAGACAGGAGAATCCCTTGAACCTGGGAGGCGGAGGTTGTGGTGAGC
CAAGATCGTGCCACTGCACTCCAGTCTGGGTGACAGAGTGAGACTCCGCCTCAAAAAGATTTAGGTTGCAAATGTTTCAAGCATGTGCAG
TTTTGTGTGTGTGTATACATATATATGGTCAGCATATATATTGTGCAGCTAGGGCGAAGCCAGCAGAGGTGTGTGTATGTCTTTATGAAA
TGTTTGAAAAGAGATAAACTGACTGCTTGATAATCACTCTCAGGTGTAAAGCTCCAAGTGTAAATAAAAGTGGCATTTAACAAATCTTTC
AGAACAAAGTACAGCTGACTATATATACCAAGAGCTAAGCTAAAGGAACAGCTGAGAGCTCCGATCTCCACGAGAGACTAATCTAAAAGC
TCTGCTTTGTACTTCCTCACCCTGCTTTCGTACAAGGAAGGGGGACGATGGGAAATCATGGACTTGTAAGTTGTATTTAAACATAAAAAT
GAACTTGGTAACTTCTGGGTTTAGTAGAGCCTCAGTGTCGCTTTAACTTAGTTTACTTTTTTTTTATTTTTAAAGCAGCAATGGATGGTT
TTAAAGGAGTATTATGATTGTAAAATTGCTAAATATGACTGTAACACAGCTTTGTGGTAGCTGTGACACAGTTCACTTGGGCAAAGGAGT
GGTGATGGACTCGTTAAAATCATATATACTTGAATAGTCCATTGACCGAAACTCTTTATAGACTATTGTGTAAATGTGGAATCACAGACT
GTTAACATTGCCTGGACTTCAGCAGAGTCCTGGAGCTGCTGGGACCTCTCCTATCATGATGAACTTGGACTTTTTTTTTTGATTTCTGGT
TTTAAAAAACATAAAATTATAGAATCCAGATAATTCGCTGGAGTCATTCTGATCCACCATGTAGATCTGTATTTAGTATCATTTGGATTT
GGAGAAGTGTTGATTACATTATGGCTGTGTAATAAAATTTTTATTAAAACTGCATCACACTGTAGCCACTTTGCCACCACCTCCCCACAT
GTAGCCGCTGAAACCCCCACGAGATGCCAATGCACACAGCAGGGAGAAAAGCCAACCAAAGAAGACCGAAGGGTATCTTTCCACCCGAGT
AGCCTCTGTAGTGATTGGGACCAAGACTAAGGACTTGTCTCCAATCTCAGCTGAGGCAGTGCCTCTGAACCAAGATCTTGGTCAGGCATT
AAGACACTGGCTTTGTCCTACCAACTAGGATTTCTTGGTGGTTCACACTATTTCTTGTGCTGGGGAATTCCCTCATTGGGCCCCTCCTCC
CTCCACAGTGTGGTTTCAGTGTTGAAGGGTGCAGCACCCAAGGTTGTTTTTATGCATTTTTTCAGTTCCTTCCAAGAAGCAAAAAGGCCA
GTGTCCATCTGCCTAGTTCATAATGTTTATAGGTCTGTTTGTCTGTCTTGCTTCTGGCAGGTGTAGGGAAAGTCTACTGCCTGCCACTCC
CTTCAAAAAGAATGTTTTTGCTTTTGTGAAGTCCTGACTTGCCACTCAAACTGTACCAATATTGTAAATAAATGTTATGCCATTTTAACA

>99495_99495_1_WWOX-RTF1_WWOX_chr16_78198186_ENST00000355860_RTF1_chr15_41745099_ENST00000389629_length(amino acids)=779AA_BP=172
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWWTFGSNKN
KKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTE
KEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREK
RKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKT
VTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDE
INKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAIS
YINQRNREWNIVESEKALVAESHNMKNQQMDPFTRRQCKPTIVSNSRDPAVQAAILAQLNAKYGSGVLPDAPKEMSKGQGKDKDLNSKSA

--------------------------------------------------------------
>99495_99495_2_WWOX-RTF1_WWOX_chr16_78198186_ENST00000406884_RTF1_chr15_41745099_ENST00000389629_length(transcript)=5341nt_BP=641nt
GCAGTGCGCAGGCGTGAGCGGTCGGGCCCCGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCG
GGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGC
CTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAA
CTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATA
TAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACG
GCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCG
AAACCGCCAAGTCTTTTGCCCTCCATGGTGCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTT
TAGAAGAATGGTGGACATTTGGGAGCAATAAAAATAAGAAGAAAGGAAAAGCCAGAAAAATAGAGAAGAAAGGAACCATGAAGAAACAGG
CCAACAAAACTGCCTCCTCAGGCAGTTCAGACAAAGACAGTTCAGCTGAGAGCTCAGCCCCTGAGGAAGGTGAAGTGTCAGACTCTGACA
GCAACAGCTCCTCTTCCAGTTCAGATTCAGACTCTTCCTCAGAAGATGAAGAGTTCCATGATGGCTATGGAGAAGACCTCATGGGAGATG
AGGAAGACAGGGCCCGTCTGGAACAGATGACAGAGAAAGAGAGAGAGCAAGAACTGTTCAATCGCATAGAGAAGAGGGAGGTGTTGAAAA
GAAGATTTGAAATCAAGAAAAAACTAAAAACAGCCAAAAAGAAAGAAAAGAAAGAAAAGAAGAAAAAGCAAGAAGAGGAGCAAGAAAAGA
AAAAACTGACACAGATTCAAGAATCTCAGGTAACATCCCACAACAAGGAACGGCGTTCCAAGCGGGATGAGAAACTAGACAAGAAATCTC
AAGCCATGGAGGAGCTAAAAGCAGAGCGAGAAAAACGAAAGAACAGAACAGCTGAGCTCCTTGCCAAAAAACAGCCATTAAAAACCAGTG
AGGTCTACTCTGATGATGAAGAGGAGGAAGAGGATGACAAATCCAGTGAAAAGTCAGACCGCTCATCACGAACATCATCGTCTGATGAAG
AAGAGGAGAAAGAAGAGATCCCTCCCAAATCCCAACCAGTTTCCTTACCTGAAGAATTGAATCGGGTTCGATTATCACGGCATAAGCTAG
AACGCTGGTGTCACATGCCCTTCTTTGCTAAAACTGTCACAGGATGTTTTGTGCGGATTGGCATCGGAAACCACAACAGCAAACCAGTTT
ACCGGGTCGCTGAGATTACGGGTGTTGTGGAAACTGCCAAAGTTTACCAACTAGGTGGCACCAGAACAAACAAAGGGCTGCAACTACGGC
ATGGCAATGACCAACGCGTGTTCCGTTTAGAGTTTGTCTCAAACCAAGAATTCACCGAAAGTGAGTTTATGAAGTGGAAAGAAGCGATGT
TCTCTGCTGGCATGCAGTTGCCCACTCTAGATGAAATCAATAAAAAGGAATTATCTATTAAAGAAGCTCTTAATTATAAATTCAATGATC
AGGACATTGAAGAGATTGTAAAAGAGAAAGAAAGGTTCAGAAAAGCTCCACCCAACTACGCTATGAAGAAGACTCAGCTACTGAAGGAAA
AGGCCATGGCTGAGGACCTGGGGGATCAGGACAAGGCCAAACAAATCCAAGATCAACTGAATGAGCTGGAGGAACGGGCAGAGGCCCTGG
ACCGCCAGCGGACCAAGAACATATCCGCTATCAGTTACATCAACCAGCGGAACCGGGAGTGGAACATTGTAGAGTCTGAGAAGGCCCTTG
TGGCTGAAAGTCACAACATGAAAAACCAACAGATGGATCCCTTTACTCGGCGGCAGTGCAAGCCTACCATCGTTTCTAATTCCAGAGACC
CAGCTGTTCAAGCTGCCATCTTGGCCCAGCTGAATGCAAAATACGGTTCTGGAGTGTTACCAGATGCTCCAAAGGAAATGAGCAAGGGTC
AAGGCAAAGATAAAGATTTGAATTCTAAGTCAGCCAGTGACCTCTCAGAAGATCTGTTCAAAGTACACGATTTTGATGTGAAGATTGACT
TACAAGTTCCCAGCTCAGAGTCAAAGGCTTTAGCCATCACCTCCAAGGCTCCGCCAGCCAAGGATGGGGCTCCAAGGAGATCTCTGAACT
TGGAAGACTACAAAAAACGACGAGGGCTTATTTGAGCACACCCAGCCTGCTGCTTCTGACCCTGCATGCCCCATCGCAGCGTCCCACCTT
TCCTCCTTTCCTTTGATTTAGCCTCTTTGGGCTGGAGCAGCTGTTGAACTGGGAAGAGACTCTAAACTGCCAGTCATCTGTAATATAAAC
CATTTGCTGTATAGACCTCCTTTGTCTGCACACCATCTCCCACCAGCCTCCCCTCCCCCAGGGCCCCACCCAGTGTGGGCCTGGGCTCTC
TTGGGCTTTATCCATGTCTTTAGATTTGTGTTTGCCTTTTGTTTTTTTAACCGCGCAGTTCATTGGCCACTCTGCACGCATTCAGTATTA
CCATGGAGCTGGGAATCTTGCTGGAGCCCCTGGGGCAATAGCAGCAGCACCAGGCGGTCTCCTCTACAGACTGCCTTGGCCCACCCATTG
AACATTCGGCACGTGACCTTGTGGGGGGAGCGGGGATTGGGCACCTGCGATCCTCTTTCCTCTCTTCATCTTTCTCTTCTGCCCTTCTTT
TTGGAAGAAGGGGTTTCAAAACCAGTTTAGTTTCCAAAAAGTGTACATTTGTGGGGGGGGGGGGTCTAATTTGAGAGCGAGAGTGTGTAT
GTGTGTGTGTGTAAGTGTGTGGATTTTTTTATCATTTTTTTAAAATGCAGTACTCTTTGTATCAGTCTGTCATGGGTCTATAGCTGTTTC
AGATTTTTTTCAGCTGTACTTGAGCATCTGAAACTGCAAGAAAGAAACTCATTAAATGTGATTCTTCTTACTAAACAGGCCTGACTGCTG
TAGCTGTGTAACTTCCCCATTCCCACCTACTCTTCCCATCCTTTCCCAACTTTGGAGAAAACTCCCCAGTTTAGCCCCCTGACCTGCAGG
CTGTGTCCTGGCAGGTGTGGGAGGGAAGCCCATGGCCAGGTACCAGGGAGGGCAGTGAATGTCTTGCTCTTCCCATGGGTACAGCCCACA
GCTTCTTGGCTGAACGTAGAACTTCTTTTTCTCACCCAGTATACCAGCCTCTTCCTGGTGATTCTGTTTTGCTGCTTTGGCAAGAACTAC
ATTTTGTTTTTAAGAGAAATTTCTGAATATGAATGTGGAGAGCAAACACAAAAAGATTTAGGTTACGCCGGGTGCAGTAGCTCACGCCTG
TAATCCCAGCACTTTGGGAGGCCTAGGCGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAATCTGACTAACACGGTGAAACCCCATCT
CTACTAAAACTACAAAACTTAGCCGGGCATGGTGGTGCGTGCCTGTAATCCCAGCTACTCGGGGGGCTGAGACAGGAGAATCCCTTGAAC
CTGGGAGGCGGAGGTTGTGGTGAGCCAAGATCGTGCCACTGCACTCCAGTCTGGGTGACAGAGTGAGACTCCGCCTCAAAAAGATTTAGG
TTGCAAATGTTTCAAGCATGTGCAGTTTTGTGTGTGTGTATACATATATATGGTCAGCATATATATTGTGCAGCTAGGGCGAAGCCAGCA
GAGGTGTGTGTATGTCTTTATGAAATGTTTGAAAAGAGATAAACTGACTGCTTGATAATCACTCTCAGGTGTAAAGCTCCAAGTGTAAAT
AAAAGTGGCATTTAACAAATCTTTCAGAACAAAGTACAGCTGACTATATATACCAAGAGCTAAGCTAAAGGAACAGCTGAGAGCTCCGAT
CTCCACGAGAGACTAATCTAAAAGCTCTGCTTTGTACTTCCTCACCCTGCTTTCGTACAAGGAAGGGGGACGATGGGAAATCATGGACTT
GTAAGTTGTATTTAAACATAAAAATGAACTTGGTAACTTCTGGGTTTAGTAGAGCCTCAGTGTCGCTTTAACTTAGTTTACTTTTTTTTT
ATTTTTAAAGCAGCAATGGATGGTTTTAAAGGAGTATTATGATTGTAAAATTGCTAAATATGACTGTAACACAGCTTTGTGGTAGCTGTG
ACACAGTTCACTTGGGCAAAGGAGTGGTGATGGACTCGTTAAAATCATATATACTTGAATAGTCCATTGACCGAAACTCTTTATAGACTA
TTGTGTAAATGTGGAATCACAGACTGTTAACATTGCCTGGACTTCAGCAGAGTCCTGGAGCTGCTGGGACCTCTCCTATCATGATGAACT
TGGACTTTTTTTTTTGATTTCTGGTTTTAAAAAACATAAAATTATAGAATCCAGATAATTCGCTGGAGTCATTCTGATCCACCATGTAGA
TCTGTATTTAGTATCATTTGGATTTGGAGAAGTGTTGATTACATTATGGCTGTGTAATAAAATTTTTATTAAAACTGCATCACACTGTAG
CCACTTTGCCACCACCTCCCCACATGTAGCCGCTGAAACCCCCACGAGATGCCAATGCACACAGCAGGGAGAAAAGCCAACCAAAGAAGA
CCGAAGGGTATCTTTCCACCCGAGTAGCCTCTGTAGTGATTGGGACCAAGACTAAGGACTTGTCTCCAATCTCAGCTGAGGCAGTGCCTC
TGAACCAAGATCTTGGTCAGGCATTAAGACACTGGCTTTGTCCTACCAACTAGGATTTCTTGGTGGTTCACACTATTTCTTGTGCTGGGG
AATTCCCTCATTGGGCCCCTCCTCCCTCCACAGTGTGGTTTCAGTGTTGAAGGGTGCAGCACCCAAGGTTGTTTTTATGCATTTTTTCAG
TTCCTTCCAAGAAGCAAAAAGGCCAGTGTCCATCTGCCTAGTTCATAATGTTTATAGGTCTGTTTGTCTGTCTTGCTTCTGGCAGGTGTA
GGGAAAGTCTACTGCCTGCCACTCCCTTCAAAAAGAATGTTTTTGCTTTTGTGAAGTCCTGACTTGCCACTCAAACTGTACCAATATTGT

>99495_99495_2_WWOX-RTF1_WWOX_chr16_78198186_ENST00000406884_RTF1_chr15_41745099_ENST00000389629_length(amino acids)=779AA_BP=172
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWWTFGSNKN
KKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTE
KEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREK
RKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKT
VTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDE
INKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAIS
YINQRNREWNIVESEKALVAESHNMKNQQMDPFTRRQCKPTIVSNSRDPAVQAAILAQLNAKYGSGVLPDAPKEMSKGQGKDKDLNSKSA

--------------------------------------------------------------
>99495_99495_3_WWOX-RTF1_WWOX_chr16_78198186_ENST00000408984_RTF1_chr15_41745099_ENST00000389629_length(transcript)=5301nt_BP=601nt
GGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAGTCAGCCATGGC
AGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAGGACGGCTGGGT
TTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGG
ATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTT
TACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTT
CACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGTGCACATGTGAT
CTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGTGGACATTTGGGAGCAATAAAAATAAGAA
GAAAGGAAAAGCCAGAAAAATAGAGAAGAAAGGAACCATGAAGAAACAGGCCAACAAAACTGCCTCCTCAGGCAGTTCAGACAAAGACAG
TTCAGCTGAGAGCTCAGCCCCTGAGGAAGGTGAAGTGTCAGACTCTGACAGCAACAGCTCCTCTTCCAGTTCAGATTCAGACTCTTCCTC
AGAAGATGAAGAGTTCCATGATGGCTATGGAGAAGACCTCATGGGAGATGAGGAAGACAGGGCCCGTCTGGAACAGATGACAGAGAAAGA
GAGAGAGCAAGAACTGTTCAATCGCATAGAGAAGAGGGAGGTGTTGAAAAGAAGATTTGAAATCAAGAAAAAACTAAAAACAGCCAAAAA
GAAAGAAAAGAAAGAAAAGAAGAAAAAGCAAGAAGAGGAGCAAGAAAAGAAAAAACTGACACAGATTCAAGAATCTCAGGTAACATCCCA
CAACAAGGAACGGCGTTCCAAGCGGGATGAGAAACTAGACAAGAAATCTCAAGCCATGGAGGAGCTAAAAGCAGAGCGAGAAAAACGAAA
GAACAGAACAGCTGAGCTCCTTGCCAAAAAACAGCCATTAAAAACCAGTGAGGTCTACTCTGATGATGAAGAGGAGGAAGAGGATGACAA
ATCCAGTGAAAAGTCAGACCGCTCATCACGAACATCATCGTCTGATGAAGAAGAGGAGAAAGAAGAGATCCCTCCCAAATCCCAACCAGT
TTCCTTACCTGAAGAATTGAATCGGGTTCGATTATCACGGCATAAGCTAGAACGCTGGTGTCACATGCCCTTCTTTGCTAAAACTGTCAC
AGGATGTTTTGTGCGGATTGGCATCGGAAACCACAACAGCAAACCAGTTTACCGGGTCGCTGAGATTACGGGTGTTGTGGAAACTGCCAA
AGTTTACCAACTAGGTGGCACCAGAACAAACAAAGGGCTGCAACTACGGCATGGCAATGACCAACGCGTGTTCCGTTTAGAGTTTGTCTC
AAACCAAGAATTCACCGAAAGTGAGTTTATGAAGTGGAAAGAAGCGATGTTCTCTGCTGGCATGCAGTTGCCCACTCTAGATGAAATCAA
TAAAAAGGAATTATCTATTAAAGAAGCTCTTAATTATAAATTCAATGATCAGGACATTGAAGAGATTGTAAAAGAGAAAGAAAGGTTCAG
AAAAGCTCCACCCAACTACGCTATGAAGAAGACTCAGCTACTGAAGGAAAAGGCCATGGCTGAGGACCTGGGGGATCAGGACAAGGCCAA
ACAAATCCAAGATCAACTGAATGAGCTGGAGGAACGGGCAGAGGCCCTGGACCGCCAGCGGACCAAGAACATATCCGCTATCAGTTACAT
CAACCAGCGGAACCGGGAGTGGAACATTGTAGAGTCTGAGAAGGCCCTTGTGGCTGAAAGTCACAACATGAAAAACCAACAGATGGATCC
CTTTACTCGGCGGCAGTGCAAGCCTACCATCGTTTCTAATTCCAGAGACCCAGCTGTTCAAGCTGCCATCTTGGCCCAGCTGAATGCAAA
ATACGGTTCTGGAGTGTTACCAGATGCTCCAAAGGAAATGAGCAAGGGTCAAGGCAAAGATAAAGATTTGAATTCTAAGTCAGCCAGTGA
CCTCTCAGAAGATCTGTTCAAAGTACACGATTTTGATGTGAAGATTGACTTACAAGTTCCCAGCTCAGAGTCAAAGGCTTTAGCCATCAC
CTCCAAGGCTCCGCCAGCCAAGGATGGGGCTCCAAGGAGATCTCTGAACTTGGAAGACTACAAAAAACGACGAGGGCTTATTTGAGCACA
CCCAGCCTGCTGCTTCTGACCCTGCATGCCCCATCGCAGCGTCCCACCTTTCCTCCTTTCCTTTGATTTAGCCTCTTTGGGCTGGAGCAG
CTGTTGAACTGGGAAGAGACTCTAAACTGCCAGTCATCTGTAATATAAACCATTTGCTGTATAGACCTCCTTTGTCTGCACACCATCTCC
CACCAGCCTCCCCTCCCCCAGGGCCCCACCCAGTGTGGGCCTGGGCTCTCTTGGGCTTTATCCATGTCTTTAGATTTGTGTTTGCCTTTT
GTTTTTTTAACCGCGCAGTTCATTGGCCACTCTGCACGCATTCAGTATTACCATGGAGCTGGGAATCTTGCTGGAGCCCCTGGGGCAATA
GCAGCAGCACCAGGCGGTCTCCTCTACAGACTGCCTTGGCCCACCCATTGAACATTCGGCACGTGACCTTGTGGGGGGAGCGGGGATTGG
GCACCTGCGATCCTCTTTCCTCTCTTCATCTTTCTCTTCTGCCCTTCTTTTTGGAAGAAGGGGTTTCAAAACCAGTTTAGTTTCCAAAAA
GTGTACATTTGTGGGGGGGGGGGGTCTAATTTGAGAGCGAGAGTGTGTATGTGTGTGTGTGTAAGTGTGTGGATTTTTTTATCATTTTTT
TAAAATGCAGTACTCTTTGTATCAGTCTGTCATGGGTCTATAGCTGTTTCAGATTTTTTTCAGCTGTACTTGAGCATCTGAAACTGCAAG
AAAGAAACTCATTAAATGTGATTCTTCTTACTAAACAGGCCTGACTGCTGTAGCTGTGTAACTTCCCCATTCCCACCTACTCTTCCCATC
CTTTCCCAACTTTGGAGAAAACTCCCCAGTTTAGCCCCCTGACCTGCAGGCTGTGTCCTGGCAGGTGTGGGAGGGAAGCCCATGGCCAGG
TACCAGGGAGGGCAGTGAATGTCTTGCTCTTCCCATGGGTACAGCCCACAGCTTCTTGGCTGAACGTAGAACTTCTTTTTCTCACCCAGT
ATACCAGCCTCTTCCTGGTGATTCTGTTTTGCTGCTTTGGCAAGAACTACATTTTGTTTTTAAGAGAAATTTCTGAATATGAATGTGGAG
AGCAAACACAAAAAGATTTAGGTTACGCCGGGTGCAGTAGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCTAGGCGGGTGGATCACC
TGAGGTCAGGAGTTCAAGACCAATCTGACTAACACGGTGAAACCCCATCTCTACTAAAACTACAAAACTTAGCCGGGCATGGTGGTGCGT
GCCTGTAATCCCAGCTACTCGGGGGGCTGAGACAGGAGAATCCCTTGAACCTGGGAGGCGGAGGTTGTGGTGAGCCAAGATCGTGCCACT
GCACTCCAGTCTGGGTGACAGAGTGAGACTCCGCCTCAAAAAGATTTAGGTTGCAAATGTTTCAAGCATGTGCAGTTTTGTGTGTGTGTA
TACATATATATGGTCAGCATATATATTGTGCAGCTAGGGCGAAGCCAGCAGAGGTGTGTGTATGTCTTTATGAAATGTTTGAAAAGAGAT
AAACTGACTGCTTGATAATCACTCTCAGGTGTAAAGCTCCAAGTGTAAATAAAAGTGGCATTTAACAAATCTTTCAGAACAAAGTACAGC
TGACTATATATACCAAGAGCTAAGCTAAAGGAACAGCTGAGAGCTCCGATCTCCACGAGAGACTAATCTAAAAGCTCTGCTTTGTACTTC
CTCACCCTGCTTTCGTACAAGGAAGGGGGACGATGGGAAATCATGGACTTGTAAGTTGTATTTAAACATAAAAATGAACTTGGTAACTTC
TGGGTTTAGTAGAGCCTCAGTGTCGCTTTAACTTAGTTTACTTTTTTTTTATTTTTAAAGCAGCAATGGATGGTTTTAAAGGAGTATTAT
GATTGTAAAATTGCTAAATATGACTGTAACACAGCTTTGTGGTAGCTGTGACACAGTTCACTTGGGCAAAGGAGTGGTGATGGACTCGTT
AAAATCATATATACTTGAATAGTCCATTGACCGAAACTCTTTATAGACTATTGTGTAAATGTGGAATCACAGACTGTTAACATTGCCTGG
ACTTCAGCAGAGTCCTGGAGCTGCTGGGACCTCTCCTATCATGATGAACTTGGACTTTTTTTTTTGATTTCTGGTTTTAAAAAACATAAA
ATTATAGAATCCAGATAATTCGCTGGAGTCATTCTGATCCACCATGTAGATCTGTATTTAGTATCATTTGGATTTGGAGAAGTGTTGATT
ACATTATGGCTGTGTAATAAAATTTTTATTAAAACTGCATCACACTGTAGCCACTTTGCCACCACCTCCCCACATGTAGCCGCTGAAACC
CCCACGAGATGCCAATGCACACAGCAGGGAGAAAAGCCAACCAAAGAAGACCGAAGGGTATCTTTCCACCCGAGTAGCCTCTGTAGTGAT
TGGGACCAAGACTAAGGACTTGTCTCCAATCTCAGCTGAGGCAGTGCCTCTGAACCAAGATCTTGGTCAGGCATTAAGACACTGGCTTTG
TCCTACCAACTAGGATTTCTTGGTGGTTCACACTATTTCTTGTGCTGGGGAATTCCCTCATTGGGCCCCTCCTCCCTCCACAGTGTGGTT
TCAGTGTTGAAGGGTGCAGCACCCAAGGTTGTTTTTATGCATTTTTTCAGTTCCTTCCAAGAAGCAAAAAGGCCAGTGTCCATCTGCCTA
GTTCATAATGTTTATAGGTCTGTTTGTCTGTCTTGCTTCTGGCAGGTGTAGGGAAAGTCTACTGCCTGCCACTCCCTTCAAAAAGAATGT

>99495_99495_3_WWOX-RTF1_WWOX_chr16_78198186_ENST00000408984_RTF1_chr15_41745099_ENST00000389629_length(amino acids)=779AA_BP=172
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWWTFGSNKN
KKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTE
KEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREK
RKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKT
VTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDE
INKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAIS
YINQRNREWNIVESEKALVAESHNMKNQQMDPFTRRQCKPTIVSNSRDPAVQAAILAQLNAKYGSGVLPDAPKEMSKGQGKDKDLNSKSA

--------------------------------------------------------------
>99495_99495_4_WWOX-RTF1_WWOX_chr16_78198186_ENST00000566780_RTF1_chr15_41745099_ENST00000389629_length(transcript)=5582nt_BP=882nt
GTCCTGGCCCGAAACTGGATGCGCACGCCCCTTCCCTGCGGCGGGGAGGCTGACAAGGCTCCGCTCTATCTCTAGCGCCTCGGAGCGCTC
TCCGGCTTTGCTGTCTAGCCCGGCGGCAGCGCGATCTCTTAGGCACTTTCACCGCCTTCCTCTCCAGGCCCTGCCCCTTTGACGCCGGCC
GTCGCGATATTGCGGAGACTGGATTTCAGCTTCGTGGTCGGCGGAGCGGCCCCTGGAGGGCGCAGTGCGCAGGCGTGAGCGGTCGGGCCC
CGACGCGCGCGGGTCTCGTTTGGAGCGGGAGTGAGTTCCTGAGCGAGTGGACCCGGCAGCGGGCGATAGGGGGGCCAGGTGCCTCCACAG
TCAGCCATGGCAGCGCTGCGCTACGCGGGGCTGGACGACACGGACAGTGAGGACGAGCTGCCTCCGGGCTGGGAGGAGAGAACCACCAAG
GACGGCTGGGTTTACTACGCCAATCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGAT
TTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCA
AGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAG
GGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGT
GCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGTGGACATTTGGGAGCAAT
AAAAATAAGAAGAAAGGAAAAGCCAGAAAAATAGAGAAGAAAGGAACCATGAAGAAACAGGCCAACAAAACTGCCTCCTCAGGCAGTTCA
GACAAAGACAGTTCAGCTGAGAGCTCAGCCCCTGAGGAAGGTGAAGTGTCAGACTCTGACAGCAACAGCTCCTCTTCCAGTTCAGATTCA
GACTCTTCCTCAGAAGATGAAGAGTTCCATGATGGCTATGGAGAAGACCTCATGGGAGATGAGGAAGACAGGGCCCGTCTGGAACAGATG
ACAGAGAAAGAGAGAGAGCAAGAACTGTTCAATCGCATAGAGAAGAGGGAGGTGTTGAAAAGAAGATTTGAAATCAAGAAAAAACTAAAA
ACAGCCAAAAAGAAAGAAAAGAAAGAAAAGAAGAAAAAGCAAGAAGAGGAGCAAGAAAAGAAAAAACTGACACAGATTCAAGAATCTCAG
GTAACATCCCACAACAAGGAACGGCGTTCCAAGCGGGATGAGAAACTAGACAAGAAATCTCAAGCCATGGAGGAGCTAAAAGCAGAGCGA
GAAAAACGAAAGAACAGAACAGCTGAGCTCCTTGCCAAAAAACAGCCATTAAAAACCAGTGAGGTCTACTCTGATGATGAAGAGGAGGAA
GAGGATGACAAATCCAGTGAAAAGTCAGACCGCTCATCACGAACATCATCGTCTGATGAAGAAGAGGAGAAAGAAGAGATCCCTCCCAAA
TCCCAACCAGTTTCCTTACCTGAAGAATTGAATCGGGTTCGATTATCACGGCATAAGCTAGAACGCTGGTGTCACATGCCCTTCTTTGCT
AAAACTGTCACAGGATGTTTTGTGCGGATTGGCATCGGAAACCACAACAGCAAACCAGTTTACCGGGTCGCTGAGATTACGGGTGTTGTG
GAAACTGCCAAAGTTTACCAACTAGGTGGCACCAGAACAAACAAAGGGCTGCAACTACGGCATGGCAATGACCAACGCGTGTTCCGTTTA
GAGTTTGTCTCAAACCAAGAATTCACCGAAAGTGAGTTTATGAAGTGGAAAGAAGCGATGTTCTCTGCTGGCATGCAGTTGCCCACTCTA
GATGAAATCAATAAAAAGGAATTATCTATTAAAGAAGCTCTTAATTATAAATTCAATGATCAGGACATTGAAGAGATTGTAAAAGAGAAA
GAAAGGTTCAGAAAAGCTCCACCCAACTACGCTATGAAGAAGACTCAGCTACTGAAGGAAAAGGCCATGGCTGAGGACCTGGGGGATCAG
GACAAGGCCAAACAAATCCAAGATCAACTGAATGAGCTGGAGGAACGGGCAGAGGCCCTGGACCGCCAGCGGACCAAGAACATATCCGCT
ATCAGTTACATCAACCAGCGGAACCGGGAGTGGAACATTGTAGAGTCTGAGAAGGCCCTTGTGGCTGAAAGTCACAACATGAAAAACCAA
CAGATGGATCCCTTTACTCGGCGGCAGTGCAAGCCTACCATCGTTTCTAATTCCAGAGACCCAGCTGTTCAAGCTGCCATCTTGGCCCAG
CTGAATGCAAAATACGGTTCTGGAGTGTTACCAGATGCTCCAAAGGAAATGAGCAAGGGTCAAGGCAAAGATAAAGATTTGAATTCTAAG
TCAGCCAGTGACCTCTCAGAAGATCTGTTCAAAGTACACGATTTTGATGTGAAGATTGACTTACAAGTTCCCAGCTCAGAGTCAAAGGCT
TTAGCCATCACCTCCAAGGCTCCGCCAGCCAAGGATGGGGCTCCAAGGAGATCTCTGAACTTGGAAGACTACAAAAAACGACGAGGGCTT
ATTTGAGCACACCCAGCCTGCTGCTTCTGACCCTGCATGCCCCATCGCAGCGTCCCACCTTTCCTCCTTTCCTTTGATTTAGCCTCTTTG
GGCTGGAGCAGCTGTTGAACTGGGAAGAGACTCTAAACTGCCAGTCATCTGTAATATAAACCATTTGCTGTATAGACCTCCTTTGTCTGC
ACACCATCTCCCACCAGCCTCCCCTCCCCCAGGGCCCCACCCAGTGTGGGCCTGGGCTCTCTTGGGCTTTATCCATGTCTTTAGATTTGT
GTTTGCCTTTTGTTTTTTTAACCGCGCAGTTCATTGGCCACTCTGCACGCATTCAGTATTACCATGGAGCTGGGAATCTTGCTGGAGCCC
CTGGGGCAATAGCAGCAGCACCAGGCGGTCTCCTCTACAGACTGCCTTGGCCCACCCATTGAACATTCGGCACGTGACCTTGTGGGGGGA
GCGGGGATTGGGCACCTGCGATCCTCTTTCCTCTCTTCATCTTTCTCTTCTGCCCTTCTTTTTGGAAGAAGGGGTTTCAAAACCAGTTTA
GTTTCCAAAAAGTGTACATTTGTGGGGGGGGGGGGTCTAATTTGAGAGCGAGAGTGTGTATGTGTGTGTGTGTAAGTGTGTGGATTTTTT
TATCATTTTTTTAAAATGCAGTACTCTTTGTATCAGTCTGTCATGGGTCTATAGCTGTTTCAGATTTTTTTCAGCTGTACTTGAGCATCT
GAAACTGCAAGAAAGAAACTCATTAAATGTGATTCTTCTTACTAAACAGGCCTGACTGCTGTAGCTGTGTAACTTCCCCATTCCCACCTA
CTCTTCCCATCCTTTCCCAACTTTGGAGAAAACTCCCCAGTTTAGCCCCCTGACCTGCAGGCTGTGTCCTGGCAGGTGTGGGAGGGAAGC
CCATGGCCAGGTACCAGGGAGGGCAGTGAATGTCTTGCTCTTCCCATGGGTACAGCCCACAGCTTCTTGGCTGAACGTAGAACTTCTTTT
TCTCACCCAGTATACCAGCCTCTTCCTGGTGATTCTGTTTTGCTGCTTTGGCAAGAACTACATTTTGTTTTTAAGAGAAATTTCTGAATA
TGAATGTGGAGAGCAAACACAAAAAGATTTAGGTTACGCCGGGTGCAGTAGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCTAGGCG
GGTGGATCACCTGAGGTCAGGAGTTCAAGACCAATCTGACTAACACGGTGAAACCCCATCTCTACTAAAACTACAAAACTTAGCCGGGCA
TGGTGGTGCGTGCCTGTAATCCCAGCTACTCGGGGGGCTGAGACAGGAGAATCCCTTGAACCTGGGAGGCGGAGGTTGTGGTGAGCCAAG
ATCGTGCCACTGCACTCCAGTCTGGGTGACAGAGTGAGACTCCGCCTCAAAAAGATTTAGGTTGCAAATGTTTCAAGCATGTGCAGTTTT
GTGTGTGTGTATACATATATATGGTCAGCATATATATTGTGCAGCTAGGGCGAAGCCAGCAGAGGTGTGTGTATGTCTTTATGAAATGTT
TGAAAAGAGATAAACTGACTGCTTGATAATCACTCTCAGGTGTAAAGCTCCAAGTGTAAATAAAAGTGGCATTTAACAAATCTTTCAGAA
CAAAGTACAGCTGACTATATATACCAAGAGCTAAGCTAAAGGAACAGCTGAGAGCTCCGATCTCCACGAGAGACTAATCTAAAAGCTCTG
CTTTGTACTTCCTCACCCTGCTTTCGTACAAGGAAGGGGGACGATGGGAAATCATGGACTTGTAAGTTGTATTTAAACATAAAAATGAAC
TTGGTAACTTCTGGGTTTAGTAGAGCCTCAGTGTCGCTTTAACTTAGTTTACTTTTTTTTTATTTTTAAAGCAGCAATGGATGGTTTTAA
AGGAGTATTATGATTGTAAAATTGCTAAATATGACTGTAACACAGCTTTGTGGTAGCTGTGACACAGTTCACTTGGGCAAAGGAGTGGTG
ATGGACTCGTTAAAATCATATATACTTGAATAGTCCATTGACCGAAACTCTTTATAGACTATTGTGTAAATGTGGAATCACAGACTGTTA
ACATTGCCTGGACTTCAGCAGAGTCCTGGAGCTGCTGGGACCTCTCCTATCATGATGAACTTGGACTTTTTTTTTTGATTTCTGGTTTTA
AAAAACATAAAATTATAGAATCCAGATAATTCGCTGGAGTCATTCTGATCCACCATGTAGATCTGTATTTAGTATCATTTGGATTTGGAG
AAGTGTTGATTACATTATGGCTGTGTAATAAAATTTTTATTAAAACTGCATCACACTGTAGCCACTTTGCCACCACCTCCCCACATGTAG
CCGCTGAAACCCCCACGAGATGCCAATGCACACAGCAGGGAGAAAAGCCAACCAAAGAAGACCGAAGGGTATCTTTCCACCCGAGTAGCC
TCTGTAGTGATTGGGACCAAGACTAAGGACTTGTCTCCAATCTCAGCTGAGGCAGTGCCTCTGAACCAAGATCTTGGTCAGGCATTAAGA
CACTGGCTTTGTCCTACCAACTAGGATTTCTTGGTGGTTCACACTATTTCTTGTGCTGGGGAATTCCCTCATTGGGCCCCTCCTCCCTCC
ACAGTGTGGTTTCAGTGTTGAAGGGTGCAGCACCCAAGGTTGTTTTTATGCATTTTTTCAGTTCCTTCCAAGAAGCAAAAAGGCCAGTGT
CCATCTGCCTAGTTCATAATGTTTATAGGTCTGTTTGTCTGTCTTGCTTCTGGCAGGTGTAGGGAAAGTCTACTGCCTGCCACTCCCTTC
AAAAAGAATGTTTTTGCTTTTGTGAAGTCCTGACTTGCCACTCAAACTGTACCAATATTGTAAATAAATGTTATGCCATTTTAACAAAGG

>99495_99495_4_WWOX-RTF1_WWOX_chr16_78198186_ENST00000566780_RTF1_chr15_41745099_ENST00000389629_length(amino acids)=779AA_BP=172
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL
AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWWTFGSNKN
KKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTE
KEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREK
RKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKT
VTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDE
INKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAIS
YINQRNREWNIVESEKALVAESHNMKNQQMDPFTRRQCKPTIVSNSRDPAVQAAILAQLNAKYGSGVLPDAPKEMSKGQGKDKDLNSKSA

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Fusion Gene PPI Analysis for WWOX-RTF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneWWOXchr16:78198186chr15:41745099ENST00000355860+56125_414172.0190.0MAPT
HgeneWWOXchr16:78198186chr15:41745099ENST00000402655+15125_4140312.0MAPT
HgeneWWOXchr16:78198186chr15:41745099ENST00000406884+56125_414172.0235.0MAPT
HgeneWWOXchr16:78198186chr15:41745099ENST00000408984+510125_414172.0311.6666666666667MAPT
HgeneWWOXchr16:78198186chr15:41745099ENST00000566780+59125_414172.0415.0MAPT
HgeneWWOXchr16:78198186chr15:41745099ENST00000569818+11125_414037.0MAPT


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WWOX-RTF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WWOX-RTF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource