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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:WWP1-NUBPL (FusionGDB2 ID:99517)

Fusion Gene Summary for WWP1-NUBPL

Fusion gene summary

Fusion gene information	Fusion gene name: WWP1-NUBPL
	Fusion gene ID: 99517
		Hgene	Tgene
	Gene symbol	WWP1	NUBPL
	Gene ID	11059	80224
	Gene name	WW domain containing E3 ubiquitin protein ligase 1	nucleotide binding protein like
	Synonyms	AIP5\|Tiul1\|hSDRP1	C14orf127\|IND1\|MC1DN21\|huInd1
	Cytomap	8q21.3	14q12
	Type of gene	protein-coding	protein-coding
	Description	NEDD4-like E3 ubiquitin-protein ligase WWP1HECT-type E3 ubiquitin transferase WWP1Nedd-4-like ubiquitin-protein ligaseTGIF-interacting ubiquitin ligase 1WW domain-containing protein 1atrophin-1 interacting protein 5	iron-sulfur protein NUBPLIND1 homologiron-sulfur protein required for NADH dehydrogenase
	Modification date	20200322	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000523863, ENST00000265428, ENST00000341922, ENST00000517970, ENST00000349423,	ENST00000281081, ENST00000536705, ENST00000418681,
Fusion gene scores	* DoF score	18 X 12 X 9=1944	17 X 14 X 7=1666
	# samples	19	17
	** MAII score	log2(19/1944*10)=-3.35495689527483 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1666*10)=-3.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: WWP1 [Title/Abstract] AND NUBPL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	WWP1(87393858)-NUBPL(32295835), # samples:3
Anticipated loss of major functional domain due to fusion event.	WWP1-NUBPL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. WWP1-NUBPL seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across WWP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUBPL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E9-A22A-01A	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
ChimerDB4	BRCA	TCGA-E9-A22A-01A	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
ChimerDB4	BRCA	TCGA-E9-A22A-01A	WWP1	chr8	87393858	-	NUBPL	chr14	32295835	+
ChimerDB4	BRCA	TCGA-E9-A22A-01A	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+

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Fusion Gene ORF analysis for WWP1-NUBPL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000523863	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
3UTR-3CDS	ENST00000523863	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
3UTR-3CDS	ENST00000523863	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
3UTR-3CDS	ENST00000523863	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
3UTR-3CDS	ENST00000523863	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
3UTR-3CDS	ENST00000523863	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
3UTR-3UTR	ENST00000523863	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
3UTR-3UTR	ENST00000523863	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
3UTR-intron	ENST00000523863	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
5CDS-3UTR	ENST00000265428	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
5CDS-3UTR	ENST00000265428	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
5CDS-3UTR	ENST00000341922	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
5CDS-3UTR	ENST00000341922	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
5CDS-3UTR	ENST00000517970	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
5CDS-3UTR	ENST00000517970	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
5CDS-intron	ENST00000265428	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
5CDS-intron	ENST00000341922	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
5CDS-intron	ENST00000517970	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
Frame-shift	ENST00000265428	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
Frame-shift	ENST00000265428	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
Frame-shift	ENST00000341922	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
Frame-shift	ENST00000341922	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
Frame-shift	ENST00000517970	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
Frame-shift	ENST00000517970	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
In-frame	ENST00000265428	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
In-frame	ENST00000265428	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
In-frame	ENST00000265428	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
In-frame	ENST00000265428	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
In-frame	ENST00000341922	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
In-frame	ENST00000341922	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
In-frame	ENST00000341922	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
In-frame	ENST00000341922	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
In-frame	ENST00000517970	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
In-frame	ENST00000517970	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
In-frame	ENST00000517970	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
In-frame	ENST00000517970	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
intron-3CDS	ENST00000349423	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
intron-3CDS	ENST00000349423	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
intron-3CDS	ENST00000349423	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
intron-3CDS	ENST00000349423	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+
intron-3CDS	ENST00000349423	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
intron-3CDS	ENST00000349423	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
intron-3UTR	ENST00000349423	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32256986	+
intron-3UTR	ENST00000349423	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+
intron-intron	ENST00000349423	ENST00000418681	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000517970	WWP1	chr8	87393858	+	ENST00000281081	NUBPL	chr14	32295835	+	3038	641	307	993	228
ENST00000517970	WWP1	chr8	87393858	+	ENST00000536705	NUBPL	chr14	32295835	+	3007	641	307	993	228
ENST00000341922	WWP1	chr8	87393858	+	ENST00000281081	NUBPL	chr14	32295835	+	2741	344	10	696	228
ENST00000341922	WWP1	chr8	87393858	+	ENST00000536705	NUBPL	chr14	32295835	+	2710	344	10	696	228
ENST00000265428	WWP1	chr8	87393858	+	ENST00000281081	NUBPL	chr14	32295835	+	2741	344	10	696	228
ENST00000265428	WWP1	chr8	87393858	+	ENST00000536705	NUBPL	chr14	32295835	+	2710	344	10	696	228
ENST00000517970	WWP1	chr8	87393858	+	ENST00000281081	NUBPL	chr14	32142561	+	3263	641	307	1218	303
ENST00000517970	WWP1	chr8	87393858	+	ENST00000536705	NUBPL	chr14	32142561	+	3232	641	307	1218	303
ENST00000341922	WWP1	chr8	87393858	+	ENST00000281081	NUBPL	chr14	32142561	+	2966	344	10	921	303
ENST00000341922	WWP1	chr8	87393858	+	ENST00000536705	NUBPL	chr14	32142561	+	2935	344	10	921	303
ENST00000265428	WWP1	chr8	87393858	+	ENST00000281081	NUBPL	chr14	32142561	+	2966	344	10	921	303
ENST00000265428	WWP1	chr8	87393858	+	ENST00000536705	NUBPL	chr14	32142561	+	2935	344	10	921	303

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000517970	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+	0.000423185	0.99957687
ENST00000517970	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+	0.000439606	0.9995604
ENST00000341922	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+	0.000530763	0.9994692
ENST00000341922	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+	0.000536769	0.99946326
ENST00000265428	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+	0.000530763	0.9994692
ENST00000265428	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32295835	+	0.000536769	0.99946326
ENST00000517970	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+	0.000203602	0.99979645
ENST00000517970	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+	0.000215831	0.9997842
ENST00000341922	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+	0.000183075	0.99981695
ENST00000341922	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+	0.00019015	0.9998099
ENST00000265428	ENST00000281081	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+	0.000183075	0.99981695
ENST00000265428	ENST00000536705	WWP1	chr8	87393858	+	NUBPL	chr14	32142561	+	0.00019015	0.9998099

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Fusion Genomic Features for WWP1-NUBPL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
WWP1	chr8	87393858	+	NUBPL	chr14	32256985	+	2.10E-05	0.999979
WWP1	chr8	87393858	+	NUBPL	chr14	32142560	+	1.16E-06	0.9999988
WWP1	chr8	87393858	+	NUBPL	chr14	32295834	+	2.34E-07	0.99999976
WWP1	chr8	87393858	+	NUBPL	chr14	32256985	+	2.10E-05	0.999979
WWP1	chr8	87393858	+	NUBPL	chr14	32142560	+	1.16E-06	0.9999988
WWP1	chr8	87393858	+	NUBPL	chr14	32295834	+	2.34E-07	0.99999976

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WWP1-NUBPL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:87393858/chr14:32295835)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000265428

1_116

111

923.0

Domain

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000265428

349_382

111

923.0

Domain

WW 1

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000265428

381_414

111

923.0

Domain

WW 2

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000265428

456_489

111

923.0

Domain

WW 3

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000265428

496_529

111

923.0

Domain

WW 4

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000265428

588_922

111

923.0

Domain

HECT

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000341922

1_116

111

793.0

Domain

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000341922

349_382

111

793.0

Domain

WW 1

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000341922

381_414

111

793.0

Domain

WW 2

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000341922

456_489

111

793.0

Domain

WW 3

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000341922

496_529

111

793.0

Domain

WW 4

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000341922

588_922

111

793.0

Domain

HECT

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000349423

1_116

705.0

Domain

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000349423

349_382

705.0

Domain

WW 1

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000349423

381_414

705.0

Domain

WW 2

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000349423

456_489

705.0

Domain

WW 3

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000349423

496_529

705.0

Domain

WW 4

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000349423

588_922

705.0

Domain

HECT

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000517970

1_116

111

923.0

Domain

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000517970

349_382

111

923.0

Domain

WW 1

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000517970

381_414

111

923.0

Domain

WW 2

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000517970

456_489

111

923.0

Domain

WW 3

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000517970

496_529

111

923.0

Domain

WW 4

Hgene

WWP1

chr8:87393858

chr14:32142561

ENST00000517970

588_922

111

923.0

Domain

HECT

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000265428

1_116

111

923.0

Domain

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000265428

349_382

111

923.0

Domain

WW 1

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000265428

381_414

111

923.0

Domain

WW 2

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000265428

456_489

111

923.0

Domain

WW 3

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000265428

496_529

111

923.0

Domain

WW 4

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000265428

588_922

111

923.0

Domain

HECT

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000341922

1_116

111

793.0

Domain

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000341922

349_382

111

793.0

Domain

WW 1

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000341922

381_414

111

793.0

Domain

WW 2

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000341922

456_489

111

793.0

Domain

WW 3

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000341922

496_529

111

793.0

Domain

WW 4

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000341922

588_922

111

793.0

Domain

HECT

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000349423

1_116

705.0

Domain

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000349423

349_382

705.0

Domain

WW 1

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000349423

381_414

705.0

Domain

WW 2

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000349423

456_489

705.0

Domain

WW 3

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000349423

496_529

705.0

Domain

WW 4

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000349423

588_922

705.0

Domain

HECT

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000517970

1_116

111

923.0

Domain

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000517970

349_382

111

923.0

Domain

WW 1

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000517970

381_414

111

923.0

Domain

WW 2

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000517970

456_489

111

923.0

Domain

WW 3

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000517970

496_529

111

923.0

Domain

WW 4

Hgene

WWP1

chr8:87393858

chr14:32295835

ENST00000517970

588_922

111

923.0

Domain

HECT

Tgene

NUBPL

chr8:87393858

chr14:32142561

ENST00000281081

75_82

127

320.0

Nucleotide binding

ATP

Tgene

NUBPL

chr8:87393858

chr14:32295835

ENST00000281081

75_82

202

320.0

Nucleotide binding

ATP

Top

Fusion Gene Sequence for WWP1-NUBPL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>99517_99517_1_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000265428_NUBPL_chr14_32142561_ENST00000281081_length(transcript)=2966nt_BP=344nt
ATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTTGCAGTTACAGGTAACTGTTTCTAGTGC
CAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGGAGAAATTACGAAAACAGCAAAATCCAG
TAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATTGGAATTTCAAGTTTGGAGCCATCGCAC
TTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACACAATAGAAAATGCAACCTAATGAGGCC
TCTCTTGAATTATGGTATTGCTTGTATGTCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGTAGTTTGGAGAGGCCTTATGGTAATGTC
GGCCATTGAGAAATTGTTGAGGCAGGTAGATTGGGGTCAACTGGACTACTTAGTTGTAGACATGCCACCAGGAACTGGAGATGTGCAGTT
ATCAGTCTCACAGAATATTCCTATAACAGGTGCTGTGATTGTCTCCACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGA
GATGTTTCGCAGAGTCCACGTGCCCGTCCTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATAT
TTTTGGTGCTGATGGTGCAAGGAAACTAGCACAGACCCTTGGTCTTGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGC
TTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAG
ATTGCCATCACCTTCAGAATGATTCCCCAAGTGTCCTGGAAATTTGCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGG
TGATGGAACCTACAGAAATAATAGAAATCATAACTGTTTTATTTCTAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCA
CAAAACTTTGATGTATCAATGTTAACTGCTATATTTAGGAATTTTTTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTT
ATTGAATTACCCCTTTAGAAATCACGAGTTTATGATGTTACAAGTCCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATT
AGTAATTTAAATGATATACTAAATTTGTGTATGGGCATAAGTATTACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTT
TGGTACTGTCTTGGACATGTTCTTAATATGAACCTCTGCTTCTTCATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCA
GGAGTGGAGCCTGAACATATGTATTTTTAGTAAGACCATGATGATGTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAA
CATTTAACAAGTTAATTATAATTGTTCTTCCATTTGTGTGAGTGGGTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATT
TGAAGGCACTCAACCTTGAGTGTCTTGCTGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTA
GATTCATCTTTTTGTACACCAATGTGCTTTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCA
CTTTGGGAGGTTGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATAC
AAAAATTAGCTGGGTGTGGTGGCATATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAG
GTTGCAGTGAGTGGAGATTGTACCACTGCACTCCAGCCTGGTCAATGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAG
TCGGGGGAGATGCAATATTTAGCATTTCCTCAAACTTTTTTTGGCCATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAG
TTCACATTTCAAATAATACATTTTGAAAAACATTTATCTTGTCTAATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGT
AGCAGATAGTTTTAAAGCTGCAAGTACTGATAAGTGTGAGCCATTAGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAA
TGTCTTGACATCTGTTGCTCTACAGTTGTCAACTAGAAAATTAGGCATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACAT
GTACATTGATGTTTATTGCAATTTTATGTGTAATAACCAAAAACAACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTA
CATTCATACCGTGAGTGCTACTCAGCAATAAAAAAGAACAAACTATGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATG
AAAAAGGCCAATTTAAAAAGGTTTTGTACCAAAAGATTCCATTTATATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGAT
TAGTGGTGGCTGTGTTAAGGAGGGGGTGAGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAAT
GTTCTATATCACAGCTATCGATGTCAGTATCCCAGTTGTGATATTGTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGA

>99517_99517_1_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000265428_NUBPL_chr14_32142561_ENST00000281081_length(amino acids)=303AA_BP=112
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKA
DALLGKATIDLKQALLIHNRKCNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVS
QNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNIREASDT

--------------------------------------------------------------
>99517_99517_2_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000265428_NUBPL_chr14_32142561_ENST00000536705_length(transcript)=2935nt_BP=344nt
ATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTTGCAGTTACAGGTAACTGTTTCTAGTGC
CAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGGAGAAATTACGAAAACAGCAAAATCCAG
TAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATTGGAATTTCAAGTTTGGAGCCATCGCAC
TTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACACAATAGAAAATGCAACCTAATGAGGCC
TCTCTTGAATTATGGTATTGCTTGTATGTCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGTAGTTTGGAGAGGCCTTATGGTAATGTC
GGCCATTGAGAAATTGTTGAGGCAGGTAGATTGGGGTCAACTGGACTACTTAGTTGTAGACATGCCACCAGGAACTGGAGATGTGCAGTT
ATCAGTCTCACAGAATATTCCTATAACAGGTGCTGTGATTGTCTCCACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGA
GATGTTTCGCAGAGTCCACGTGCCCGTCCTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATAT
TTTTGGTGCTGATGGTGCAAGGAAACTAGCACAGACCCTTGGTCTTGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGC
TTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAG
ATTGCCATCACCTTCAGAATGATTCCCCAAGTGTCCTGGAAATTTGCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGG
TGATGGAACCTACAGAAATAATAGAAATCATAACTGTTTTATTTCTAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCA
CAAAACTTTGATGTATCAATGTTAACTGCTATATTTAGGAATTTTTTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTT
ATTGAATTACCCCTTTAGAAATCACGAGTTTATGATGTTACAAGTCCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATT
AGTAATTTAAATGATATACTAAATTTGTGTATGGGCATAAGTATTACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTT
TGGTACTGTCTTGGACATGTTCTTAATATGAACCTCTGCTTCTTCATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCA
GGAGTGGAGCCTGAACATATGTATTTTTAGTAAGACCATGATGATGTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAA
CATTTAACAAGTTAATTATAATTGTTCTTCCATTTGTGTGAGTGGGTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATT
TGAAGGCACTCAACCTTGAGTGTCTTGCTGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTA
GATTCATCTTTTTGTACACCAATGTGCTTTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCA
CTTTGGGAGGTTGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATAC
AAAAATTAGCTGGGTGTGGTGGCATATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAG
GTTGCAGTGAGTGGAGATTGTACCACTGCACTCCAGCCTGGTCAATGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAG
TCGGGGGAGATGCAATATTTAGCATTTCCTCAAACTTTTTTTGGCCATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAG
TTCACATTTCAAATAATACATTTTGAAAAACATTTATCTTGTCTAATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGT
AGCAGATAGTTTTAAAGCTGCAAGTACTGATAAGTGTGAGCCATTAGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAA
TGTCTTGACATCTGTTGCTCTACAGTTGTCAACTAGAAAATTAGGCATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACAT
GTACATTGATGTTTATTGCAATTTTATGTGTAATAACCAAAAACAACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTA
CATTCATACCGTGAGTGCTACTCAGCAATAAAAAAGAACAAACTATGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATG
AAAAAGGCCAATTTAAAAAGGTTTTGTACCAAAAGATTCCATTTATATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGAT
TAGTGGTGGCTGTGTTAAGGAGGGGGTGAGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAAT
GTTCTATATCACAGCTATCGATGTCAGTATCCCAGTTGTGATATTGTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGA

>99517_99517_2_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000265428_NUBPL_chr14_32142561_ENST00000536705_length(amino acids)=303AA_BP=112
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKA
DALLGKATIDLKQALLIHNRKCNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVS
QNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNIREASDT

--------------------------------------------------------------
>99517_99517_3_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000265428_NUBPL_chr14_32295835_ENST00000281081_length(transcript)=2741nt_BP=344nt
ATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTTGCAGTTACAGGTAACTGTTTCTAGTGC
CAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGGAGAAATTACGAAAACAGCAAAATCCAG
TAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATTGGAATTTCAAGTTTGGAGCCATCGCAC
TTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACACAATAGAAAATGTGCTGTGATTGTCTC
CACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCACGTGCCCGTCCTTGGCCTTGTCCAAAA
CATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGGAAACTAGCACAGACCCTTGGTCT
TGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGA
TGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGAATGATTCCCCAAGTGTCCTGGAAATTT
GCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTACAGAAATAATAGAAATCATAACTGTTTTATTTC
TAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCACAAAACTTTGATGTATCAATGTTAACTGCTATATTTAGGAATTTT
TTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTTATTGAATTACCCCTTTAGAAATCACGAGTTTATGATGTTACAAGT
CCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATTAGTAATTTAAATGATATACTAAATTTGTGTATGGGCATAAGTATT
ACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACATGTTCTTAATATGAACCTCTGCTTCTTC
ATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACATATGTATTTTTAGTAAGACCATGATGAT
GTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTATAATTGTTCTTCCATTTGTGTGAGTGG
GTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTGAGTGTCTTGCTGAGGGTTACTGTATCT
AGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTTTGTACACCAATGTGCTTTTGTTAATTAAAAAAA
GTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAG
ACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCATATGCCTGTAATCCCAGCTAC
TCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGATTGTACCACTGCACTCCAGCCTGGTCAA
TGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATATTTAGCATTTCCTCAAACTTTTTTTGGC
CATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATACATTTTGAAAAACATTTATCTTGTCTA
ATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGCTGCAAGTACTGATAAGTGTGAGCCATT
AGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGCTCTACAGTTGTCAACTAGAAAATTAGG
CATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACATGTACATTGATGTTTATTGCAATTTTATGTGTAATAACCAAAAACA
ACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTACATTCATACCGTGAGTGCTACTCAGCAATAAAAAAGAACAAACTA
TGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATGAAAAAGGCCAATTTAAAAAGGTTTTGTACCAAAAGATTCCATTTA
TATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAAGGAGGGGGTGAGGATGGGAGAGAATTG
GGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTATCGATGTCAGTATCCCAGTTGTGATATT
GTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGAAGGGCACATGGAATCTCTGTATTATTTCAACTGCATGTAAATCTA

>99517_99517_3_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000265428_NUBPL_chr14_32295835_ENST00000281081_length(amino acids)=228AA_BP=112
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKA
DALLGKATIDLKQALLIHNRKCAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVL

--------------------------------------------------------------
>99517_99517_4_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000265428_NUBPL_chr14_32295835_ENST00000536705_length(transcript)=2710nt_BP=344nt
ATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTTGCAGTTACAGGTAACTGTTTCTAGTGC
CAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGGAGAAATTACGAAAACAGCAAAATCCAG
TAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATTGGAATTTCAAGTTTGGAGCCATCGCAC
TTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACACAATAGAAAATGTGCTGTGATTGTCTC
CACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCACGTGCCCGTCCTTGGCCTTGTCCAAAA
CATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGGAAACTAGCACAGACCCTTGGTCT
TGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGA
TGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGAATGATTCCCCAAGTGTCCTGGAAATTT
GCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTACAGAAATAATAGAAATCATAACTGTTTTATTTC
TAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCACAAAACTTTGATGTATCAATGTTAACTGCTATATTTAGGAATTTT
TTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTTATTGAATTACCCCTTTAGAAATCACGAGTTTATGATGTTACAAGT
CCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATTAGTAATTTAAATGATATACTAAATTTGTGTATGGGCATAAGTATT
ACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACATGTTCTTAATATGAACCTCTGCTTCTTC
ATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACATATGTATTTTTAGTAAGACCATGATGAT
GTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTATAATTGTTCTTCCATTTGTGTGAGTGG
GTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTGAGTGTCTTGCTGAGGGTTACTGTATCT
AGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTTTGTACACCAATGTGCTTTTGTTAATTAAAAAAA
GTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAG
ACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCATATGCCTGTAATCCCAGCTAC
TCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGATTGTACCACTGCACTCCAGCCTGGTCAA
TGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATATTTAGCATTTCCTCAAACTTTTTTTGGC
CATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATACATTTTGAAAAACATTTATCTTGTCTA
ATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGCTGCAAGTACTGATAAGTGTGAGCCATT
AGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGCTCTACAGTTGTCAACTAGAAAATTAGG
CATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACATGTACATTGATGTTTATTGCAATTTTATGTGTAATAACCAAAAACA
ACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTACATTCATACCGTGAGTGCTACTCAGCAATAAAAAAGAACAAACTA
TGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATGAAAAAGGCCAATTTAAAAAGGTTTTGTACCAAAAGATTCCATTTA
TATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAAGGAGGGGGTGAGGATGGGAGAGAATTG
GGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTATCGATGTCAGTATCCCAGTTGTGATATT
GTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGAAGGGCACATGGAATCTCTGTATTATTTCAACTGCATGTAAATCTA

>99517_99517_4_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000265428_NUBPL_chr14_32295835_ENST00000536705_length(amino acids)=228AA_BP=112
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKA
DALLGKATIDLKQALLIHNRKCAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVL

--------------------------------------------------------------
>99517_99517_5_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000341922_NUBPL_chr14_32142561_ENST00000281081_length(transcript)=2966nt_BP=344nt
ATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTTGCAGTTACAGGTAACTGTTTCTAGTGC
CAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGGAGAAATTACGAAAACAGCAAAATCCAG
TAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATTGGAATTTCAAGTTTGGAGCCATCGCAC
TTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACACAATAGAAAATGCAACCTAATGAGGCC
TCTCTTGAATTATGGTATTGCTTGTATGTCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGTAGTTTGGAGAGGCCTTATGGTAATGTC
GGCCATTGAGAAATTGTTGAGGCAGGTAGATTGGGGTCAACTGGACTACTTAGTTGTAGACATGCCACCAGGAACTGGAGATGTGCAGTT
ATCAGTCTCACAGAATATTCCTATAACAGGTGCTGTGATTGTCTCCACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGA
GATGTTTCGCAGAGTCCACGTGCCCGTCCTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATAT
TTTTGGTGCTGATGGTGCAAGGAAACTAGCACAGACCCTTGGTCTTGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGC
TTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAG
ATTGCCATCACCTTCAGAATGATTCCCCAAGTGTCCTGGAAATTTGCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGG
TGATGGAACCTACAGAAATAATAGAAATCATAACTGTTTTATTTCTAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCA
CAAAACTTTGATGTATCAATGTTAACTGCTATATTTAGGAATTTTTTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTT
ATTGAATTACCCCTTTAGAAATCACGAGTTTATGATGTTACAAGTCCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATT
AGTAATTTAAATGATATACTAAATTTGTGTATGGGCATAAGTATTACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTT
TGGTACTGTCTTGGACATGTTCTTAATATGAACCTCTGCTTCTTCATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCA
GGAGTGGAGCCTGAACATATGTATTTTTAGTAAGACCATGATGATGTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAA
CATTTAACAAGTTAATTATAATTGTTCTTCCATTTGTGTGAGTGGGTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATT
TGAAGGCACTCAACCTTGAGTGTCTTGCTGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTA
GATTCATCTTTTTGTACACCAATGTGCTTTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCA
CTTTGGGAGGTTGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATAC
AAAAATTAGCTGGGTGTGGTGGCATATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAG
GTTGCAGTGAGTGGAGATTGTACCACTGCACTCCAGCCTGGTCAATGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAG
TCGGGGGAGATGCAATATTTAGCATTTCCTCAAACTTTTTTTGGCCATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAG
TTCACATTTCAAATAATACATTTTGAAAAACATTTATCTTGTCTAATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGT
AGCAGATAGTTTTAAAGCTGCAAGTACTGATAAGTGTGAGCCATTAGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAA
TGTCTTGACATCTGTTGCTCTACAGTTGTCAACTAGAAAATTAGGCATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACAT
GTACATTGATGTTTATTGCAATTTTATGTGTAATAACCAAAAACAACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTA
CATTCATACCGTGAGTGCTACTCAGCAATAAAAAAGAACAAACTATGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATG
AAAAAGGCCAATTTAAAAAGGTTTTGTACCAAAAGATTCCATTTATATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGAT
TAGTGGTGGCTGTGTTAAGGAGGGGGTGAGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAAT
GTTCTATATCACAGCTATCGATGTCAGTATCCCAGTTGTGATATTGTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGA

>99517_99517_5_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000341922_NUBPL_chr14_32142561_ENST00000281081_length(amino acids)=303AA_BP=112
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKA
DALLGKATIDLKQALLIHNRKCNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVS
QNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNIREASDT

--------------------------------------------------------------
>99517_99517_6_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000341922_NUBPL_chr14_32142561_ENST00000536705_length(transcript)=2935nt_BP=344nt
ATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTTGCAGTTACAGGTAACTGTTTCTAGTGC
CAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGGAGAAATTACGAAAACAGCAAAATCCAG
TAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATTGGAATTTCAAGTTTGGAGCCATCGCAC
TTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACACAATAGAAAATGCAACCTAATGAGGCC
TCTCTTGAATTATGGTATTGCTTGTATGTCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGTAGTTTGGAGAGGCCTTATGGTAATGTC
GGCCATTGAGAAATTGTTGAGGCAGGTAGATTGGGGTCAACTGGACTACTTAGTTGTAGACATGCCACCAGGAACTGGAGATGTGCAGTT
ATCAGTCTCACAGAATATTCCTATAACAGGTGCTGTGATTGTCTCCACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGA
GATGTTTCGCAGAGTCCACGTGCCCGTCCTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATAT
TTTTGGTGCTGATGGTGCAAGGAAACTAGCACAGACCCTTGGTCTTGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGC
TTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAG
ATTGCCATCACCTTCAGAATGATTCCCCAAGTGTCCTGGAAATTTGCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGG
TGATGGAACCTACAGAAATAATAGAAATCATAACTGTTTTATTTCTAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCA
CAAAACTTTGATGTATCAATGTTAACTGCTATATTTAGGAATTTTTTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTT
ATTGAATTACCCCTTTAGAAATCACGAGTTTATGATGTTACAAGTCCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATT
AGTAATTTAAATGATATACTAAATTTGTGTATGGGCATAAGTATTACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTT
TGGTACTGTCTTGGACATGTTCTTAATATGAACCTCTGCTTCTTCATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCA
GGAGTGGAGCCTGAACATATGTATTTTTAGTAAGACCATGATGATGTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAA
CATTTAACAAGTTAATTATAATTGTTCTTCCATTTGTGTGAGTGGGTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATT
TGAAGGCACTCAACCTTGAGTGTCTTGCTGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTA
GATTCATCTTTTTGTACACCAATGTGCTTTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCA
CTTTGGGAGGTTGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATAC
AAAAATTAGCTGGGTGTGGTGGCATATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAG
GTTGCAGTGAGTGGAGATTGTACCACTGCACTCCAGCCTGGTCAATGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAG
TCGGGGGAGATGCAATATTTAGCATTTCCTCAAACTTTTTTTGGCCATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAG
TTCACATTTCAAATAATACATTTTGAAAAACATTTATCTTGTCTAATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGT
AGCAGATAGTTTTAAAGCTGCAAGTACTGATAAGTGTGAGCCATTAGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAA
TGTCTTGACATCTGTTGCTCTACAGTTGTCAACTAGAAAATTAGGCATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACAT
GTACATTGATGTTTATTGCAATTTTATGTGTAATAACCAAAAACAACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTA
CATTCATACCGTGAGTGCTACTCAGCAATAAAAAAGAACAAACTATGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATG
AAAAAGGCCAATTTAAAAAGGTTTTGTACCAAAAGATTCCATTTATATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGAT
TAGTGGTGGCTGTGTTAAGGAGGGGGTGAGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAAT
GTTCTATATCACAGCTATCGATGTCAGTATCCCAGTTGTGATATTGTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGA

>99517_99517_6_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000341922_NUBPL_chr14_32142561_ENST00000536705_length(amino acids)=303AA_BP=112
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKA
DALLGKATIDLKQALLIHNRKCNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVS
QNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNIREASDT

--------------------------------------------------------------
>99517_99517_7_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000341922_NUBPL_chr14_32295835_ENST00000281081_length(transcript)=2741nt_BP=344nt
ATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTTGCAGTTACAGGTAACTGTTTCTAGTGC
CAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGGAGAAATTACGAAAACAGCAAAATCCAG
TAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATTGGAATTTCAAGTTTGGAGCCATCGCAC
TTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACACAATAGAAAATGTGCTGTGATTGTCTC
CACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCACGTGCCCGTCCTTGGCCTTGTCCAAAA
CATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGGAAACTAGCACAGACCCTTGGTCT
TGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGA
TGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGAATGATTCCCCAAGTGTCCTGGAAATTT
GCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTACAGAAATAATAGAAATCATAACTGTTTTATTTC
TAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCACAAAACTTTGATGTATCAATGTTAACTGCTATATTTAGGAATTTT
TTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTTATTGAATTACCCCTTTAGAAATCACGAGTTTATGATGTTACAAGT
CCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATTAGTAATTTAAATGATATACTAAATTTGTGTATGGGCATAAGTATT
ACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACATGTTCTTAATATGAACCTCTGCTTCTTC
ATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACATATGTATTTTTAGTAAGACCATGATGAT
GTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTATAATTGTTCTTCCATTTGTGTGAGTGG
GTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTGAGTGTCTTGCTGAGGGTTACTGTATCT
AGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTTTGTACACCAATGTGCTTTTGTTAATTAAAAAAA
GTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAG
ACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCATATGCCTGTAATCCCAGCTAC
TCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGATTGTACCACTGCACTCCAGCCTGGTCAA
TGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATATTTAGCATTTCCTCAAACTTTTTTTGGC
CATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATACATTTTGAAAAACATTTATCTTGTCTA
ATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGCTGCAAGTACTGATAAGTGTGAGCCATT
AGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGCTCTACAGTTGTCAACTAGAAAATTAGG
CATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACATGTACATTGATGTTTATTGCAATTTTATGTGTAATAACCAAAAACA
ACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTACATTCATACCGTGAGTGCTACTCAGCAATAAAAAAGAACAAACTA
TGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATGAAAAAGGCCAATTTAAAAAGGTTTTGTACCAAAAGATTCCATTTA
TATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAAGGAGGGGGTGAGGATGGGAGAGAATTG
GGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTATCGATGTCAGTATCCCAGTTGTGATATT
GTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGAAGGGCACATGGAATCTCTGTATTATTTCAACTGCATGTAAATCTA

>99517_99517_7_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000341922_NUBPL_chr14_32295835_ENST00000281081_length(amino acids)=228AA_BP=112
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKA
DALLGKATIDLKQALLIHNRKCAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVL

--------------------------------------------------------------
>99517_99517_8_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000341922_NUBPL_chr14_32295835_ENST00000536705_length(transcript)=2710nt_BP=344nt
ATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTTGCAGTTACAGGTAACTGTTTCTAGTGC
CAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGGAGAAATTACGAAAACAGCAAAATCCAG
TAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATTGGAATTTCAAGTTTGGAGCCATCGCAC
TTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACACAATAGAAAATGTGCTGTGATTGTCTC
CACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCACGTGCCCGTCCTTGGCCTTGTCCAAAA
CATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGGAAACTAGCACAGACCCTTGGTCT
TGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGA
TGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGAATGATTCCCCAAGTGTCCTGGAAATTT
GCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTACAGAAATAATAGAAATCATAACTGTTTTATTTC
TAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCACAAAACTTTGATGTATCAATGTTAACTGCTATATTTAGGAATTTT
TTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTTATTGAATTACCCCTTTAGAAATCACGAGTTTATGATGTTACAAGT
CCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATTAGTAATTTAAATGATATACTAAATTTGTGTATGGGCATAAGTATT
ACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACATGTTCTTAATATGAACCTCTGCTTCTTC
ATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACATATGTATTTTTAGTAAGACCATGATGAT
GTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTATAATTGTTCTTCCATTTGTGTGAGTGG
GTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTGAGTGTCTTGCTGAGGGTTACTGTATCT
AGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTTTGTACACCAATGTGCTTTTGTTAATTAAAAAAA
GTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAG
ACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCATATGCCTGTAATCCCAGCTAC
TCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGATTGTACCACTGCACTCCAGCCTGGTCAA
TGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATATTTAGCATTTCCTCAAACTTTTTTTGGC
CATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATACATTTTGAAAAACATTTATCTTGTCTA
ATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGCTGCAAGTACTGATAAGTGTGAGCCATT
AGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGCTCTACAGTTGTCAACTAGAAAATTAGG
CATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACATGTACATTGATGTTTATTGCAATTTTATGTGTAATAACCAAAAACA
ACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTACATTCATACCGTGAGTGCTACTCAGCAATAAAAAAGAACAAACTA
TGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATGAAAAAGGCCAATTTAAAAAGGTTTTGTACCAAAAGATTCCATTTA
TATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAAGGAGGGGGTGAGGATGGGAGAGAATTG
GGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTATCGATGTCAGTATCCCAGTTGTGATATT
GTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGAAGGGCACATGGAATCTCTGTATTATTTCAACTGCATGTAAATCTA

>99517_99517_8_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000341922_NUBPL_chr14_32295835_ENST00000536705_length(amino acids)=228AA_BP=112
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKA
DALLGKATIDLKQALLIHNRKCAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVL

--------------------------------------------------------------
>99517_99517_9_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000517970_NUBPL_chr14_32142561_ENST00000281081_length(transcript)=3263nt_BP=641nt
GGCGAGCTCCGCGTGCGGGTTCCGAGTGGCTGCTGGCGGCCTGGGCTGCCGGGGCCGACGCCTGGGTGGCTGCTGCCGCCGCGCCTGCTG
CGAGATGGCGATCTTGGGCGCGGAAGGGTGAGGGCGCCCGCCGCAGGAGGAGGTGCCGCTGCCGTGGCCGCCCGGCTGCCGGGAGCCGAC
AGCTTCGCGCCGGGGTTGTCTCCTCACAGACTATGAGCTCCTTGAAAGAGGGAATCGTGTCTTACTCATCTTTGTATCCCCAGTGTCTAG
CAGTTCCTGATACATAGTTTTAGCTGAATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTT
GCAGTTACAGGTAACTGTTTCTAGTGCCAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGG
AGAAATTACGAAAACAGCAAAATCCAGTAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATT
GGAATTTCAAGTTTGGAGCCATCGCACTTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACA
CAATAGAAAATGCAACCTAATGAGGCCTCTCTTGAATTATGGTATTGCTTGTATGTCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGT
AGTTTGGAGAGGCCTTATGGTAATGTCGGCCATTGAGAAATTGTTGAGGCAGGTAGATTGGGGTCAACTGGACTACTTAGTTGTAGACAT
GCCACCAGGAACTGGAGATGTGCAGTTATCAGTCTCACAGAATATTCCTATAACAGGTGCTGTGATTGTCTCCACGCCCCAGGACATCGC
ATTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCACGTGCCCGTCCTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTG
TCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGGAAACTAGCACAGACCCTTGGTCTTGAAGTTCTAGGAGACAT
TCCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTT
GAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGAATGATTCCCCAAGTGTCCTGGAAATTTGCCTGGTACTGACATTAA
GAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTACAGAAATAATAGAAATCATAACTGTTTTATTTCTAAGGAAAGAATGTCTTC
ATATTTGACTTGCTAAGCTAAGGTTCACAAAACTTTGATGTATCAATGTTAACTGCTATATTTAGGAATTTTTTGAAAGCTGGTGTGTAC
CACCTGCAAAGAACTGCATTTTATTTTATTGAATTACCCCTTTAGAAATCACGAGTTTATGATGTTACAAGTCCATTTTGGGAGAGAACT
GTACACTTTTTGCAGGACCACAGAATTAGTAATTTAAATGATATACTAAATTTGTGTATGGGCATAAGTATTACGCCTTCCCACCAGGCA
ATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACATGTTCTTAATATGAACCTCTGCTTCTTCATCTGGATCACACTATAC
CCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACATATGTATTTTTAGTAAGACCATGATGATGTTGATGATGATTCTGGT
AATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTATAATTGTTCTTCCATTTGTGTGAGTGGGTACTATTATCTCCATTT
TACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTGAGTGTCTTGCTGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTG
GATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTTTGTACACCAATGTGCTTTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCG
TGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATG
GTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCATATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGG
AGAATCATTTCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGATTGTACCACTGCACTCCAGCCTGGTCAATGGAGTGCGACTCCATCT
CAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATATTTAGCATTTCCTCAAACTTTTTTTGGCCATGAAATCCACCACCCC
CCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATACATTTTGAAAAACATTTATCTTGTCTAATTGAAGCTCAAAGAGAT
AGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGCTGCAAGTACTGATAAGTGTGAGCCATTAGTTAATTCGCATTTATA
AAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGCTCTACAGTTGTCAACTAGAAAATTAGGCATAGAGTTTCACATTAT
TATAAGCATGTTTTCACACAAAAACATGTACATTGATGTTTATTGCAATTTTATGTGTAATAACCAAAAACAACCCAGATTTTCTTCATT
GGGTAAATGATTAAACAAACCATAGTACATTCATACCGTGAGTGCTACTCAGCAATAAAAAAGAACAAACTATGGGTACAGGCAGCAACT
TATAATTCCAGAGAATTATGCTGAATGAAAAAGGCCAATTTAAAAAGGTTTTGTACCAAAAGATTCCATTTATATAACGTTCTTGAAGTG
ACATAATTATAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAAGGAGGGGGTGAGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAAC
ATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTATCGATGTCAGTATCCCAGTTGTGATATTGTGCTATAGTTTTGCAAG
ATGTTACCACTGGGGGAAATTGGGTGAAGGGCACATGGAATCTCTGTATTATTTCAACTGCATGTAAATCTACAATTATCTCAAAATAAA

>99517_99517_9_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000517970_NUBPL_chr14_32142561_ENST00000281081_length(amino acids)=303AA_BP=112
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKA
DALLGKATIDLKQALLIHNRKCNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVS
QNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNIREASDT

--------------------------------------------------------------
>99517_99517_10_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000517970_NUBPL_chr14_32142561_ENST00000536705_length(transcript)=3232nt_BP=641nt
GGCGAGCTCCGCGTGCGGGTTCCGAGTGGCTGCTGGCGGCCTGGGCTGCCGGGGCCGACGCCTGGGTGGCTGCTGCCGCCGCGCCTGCTG
CGAGATGGCGATCTTGGGCGCGGAAGGGTGAGGGCGCCCGCCGCAGGAGGAGGTGCCGCTGCCGTGGCCGCCCGGCTGCCGGGAGCCGAC
AGCTTCGCGCCGGGGTTGTCTCCTCACAGACTATGAGCTCCTTGAAAGAGGGAATCGTGTCTTACTCATCTTTGTATCCCCAGTGTCTAG
CAGTTCCTGATACATAGTTTTAGCTGAATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTT
GCAGTTACAGGTAACTGTTTCTAGTGCCAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGG
AGAAATTACGAAAACAGCAAAATCCAGTAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATT
GGAATTTCAAGTTTGGAGCCATCGCACTTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACA
CAATAGAAAATGCAACCTAATGAGGCCTCTCTTGAATTATGGTATTGCTTGTATGTCTATGGGCTTTCTGGTTGAAGAAAGTGAACCAGT
AGTTTGGAGAGGCCTTATGGTAATGTCGGCCATTGAGAAATTGTTGAGGCAGGTAGATTGGGGTCAACTGGACTACTTAGTTGTAGACAT
GCCACCAGGAACTGGAGATGTGCAGTTATCAGTCTCACAGAATATTCCTATAACAGGTGCTGTGATTGTCTCCACGCCCCAGGACATCGC
ATTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCACGTGCCCGTCCTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTG
TCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGCAAGGAAACTAGCACAGACCCTTGGTCTTGAAGTTCTAGGAGACAT
TCCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCCAATTGTGTTTTCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTT
GAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGAATGATTCCCCAAGTGTCCTGGAAATTTGCCTGGTACTGACATTAA
GAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTACAGAAATAATAGAAATCATAACTGTTTTATTTCTAAGGAAAGAATGTCTTC
ATATTTGACTTGCTAAGCTAAGGTTCACAAAACTTTGATGTATCAATGTTAACTGCTATATTTAGGAATTTTTTGAAAGCTGGTGTGTAC
CACCTGCAAAGAACTGCATTTTATTTTATTGAATTACCCCTTTAGAAATCACGAGTTTATGATGTTACAAGTCCATTTTGGGAGAGAACT
GTACACTTTTTGCAGGACCACAGAATTAGTAATTTAAATGATATACTAAATTTGTGTATGGGCATAAGTATTACGCCTTCCCACCAGGCA
ATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACATGTTCTTAATATGAACCTCTGCTTCTTCATCTGGATCACACTATAC
CCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACATATGTATTTTTAGTAAGACCATGATGATGTTGATGATGATTCTGGT
AATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTATAATTGTTCTTCCATTTGTGTGAGTGGGTACTATTATCTCCATTT
TACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTGAGTGTCTTGCTGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTG
GATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTTTGTACACCAATGTGCTTTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCG
TGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATG
GTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCATATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGG
AGAATCATTTCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGATTGTACCACTGCACTCCAGCCTGGTCAATGGAGTGCGACTCCATCT
CAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATATTTAGCATTTCCTCAAACTTTTTTTGGCCATGAAATCCACCACCCC
CCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATACATTTTGAAAAACATTTATCTTGTCTAATTGAAGCTCAAAGAGAT
AGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGCTGCAAGTACTGATAAGTGTGAGCCATTAGTTAATTCGCATTTATA
AAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGCTCTACAGTTGTCAACTAGAAAATTAGGCATAGAGTTTCACATTAT
TATAAGCATGTTTTCACACAAAAACATGTACATTGATGTTTATTGCAATTTTATGTGTAATAACCAAAAACAACCCAGATTTTCTTCATT
GGGTAAATGATTAAACAAACCATAGTACATTCATACCGTGAGTGCTACTCAGCAATAAAAAAGAACAAACTATGGGTACAGGCAGCAACT
TATAATTCCAGAGAATTATGCTGAATGAAAAAGGCCAATTTAAAAAGGTTTTGTACCAAAAGATTCCATTTATATAACGTTCTTGAAGTG
ACATAATTATAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAAGGAGGGGGTGAGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAAC
ATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTATCGATGTCAGTATCCCAGTTGTGATATTGTGCTATAGTTTTGCAAG

>99517_99517_10_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000517970_NUBPL_chr14_32142561_ENST00000536705_length(amino acids)=303AA_BP=112
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKA
DALLGKATIDLKQALLIHNRKCNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVS
QNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVLGDIPLHLNIREASDT

--------------------------------------------------------------
>99517_99517_11_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000517970_NUBPL_chr14_32295835_ENST00000281081_length(transcript)=3038nt_BP=641nt
GGCGAGCTCCGCGTGCGGGTTCCGAGTGGCTGCTGGCGGCCTGGGCTGCCGGGGCCGACGCCTGGGTGGCTGCTGCCGCCGCGCCTGCTG
CGAGATGGCGATCTTGGGCGCGGAAGGGTGAGGGCGCCCGCCGCAGGAGGAGGTGCCGCTGCCGTGGCCGCCCGGCTGCCGGGAGCCGAC
AGCTTCGCGCCGGGGTTGTCTCCTCACAGACTATGAGCTCCTTGAAAGAGGGAATCGTGTCTTACTCATCTTTGTATCCCCAGTGTCTAG
CAGTTCCTGATACATAGTTTTAGCTGAATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTT
GCAGTTACAGGTAACTGTTTCTAGTGCCAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGG
AGAAATTACGAAAACAGCAAAATCCAGTAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATT
GGAATTTCAAGTTTGGAGCCATCGCACTTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACA
CAATAGAAAATGTGCTGTGATTGTCTCCACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCA
CGTGCCCGTCCTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGC
AAGGAAACTAGCACAGACCCTTGGTCTTGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCC
AATTGTGTTTTCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGA
ATGATTCCCCAAGTGTCCTGGAAATTTGCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTACAGAAA
TAATAGAAATCATAACTGTTTTATTTCTAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCACAAAACTTTGATGTATCA
ATGTTAACTGCTATATTTAGGAATTTTTTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTTATTGAATTACCCCTTTAG
AAATCACGAGTTTATGATGTTACAAGTCCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATTAGTAATTTAAATGATATA
CTAAATTTGTGTATGGGCATAAGTATTACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACAT
GTTCTTAATATGAACCTCTGCTTCTTCATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACAT
ATGTATTTTTAGTAAGACCATGATGATGTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTA
TAATTGTTCTTCCATTTGTGTGAGTGGGTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTG
AGTGTCTTGCTGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTTTGTACA
CCAATGTGCTTTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTG
GGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTG
GTGGCATATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGAT
TGTACCACTGCACTCCAGCCTGGTCAATGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATAT
TTAGCATTTCCTCAAACTTTTTTTGGCCATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATA
CATTTTGAAAAACATTTATCTTGTCTAATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGC
TGCAAGTACTGATAAGTGTGAGCCATTAGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGC
TCTACAGTTGTCAACTAGAAAATTAGGCATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACATGTACATTGATGTTTATTG
CAATTTTATGTGTAATAACCAAAAACAACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTACATTCATACCGTGAGTGC
TACTCAGCAATAAAAAAGAACAAACTATGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATGAAAAAGGCCAATTTAAAA
AGGTTTTGTACCAAAAGATTCCATTTATATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAA
GGAGGGGGTGAGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTAT
CGATGTCAGTATCCCAGTTGTGATATTGTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGAAGGGCACATGGAATCTCT

>99517_99517_11_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000517970_NUBPL_chr14_32295835_ENST00000281081_length(amino acids)=228AA_BP=112
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKA
DALLGKATIDLKQALLIHNRKCAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVL

--------------------------------------------------------------
>99517_99517_12_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000517970_NUBPL_chr14_32295835_ENST00000536705_length(transcript)=3007nt_BP=641nt
GGCGAGCTCCGCGTGCGGGTTCCGAGTGGCTGCTGGCGGCCTGGGCTGCCGGGGCCGACGCCTGGGTGGCTGCTGCCGCCGCGCCTGCTG
CGAGATGGCGATCTTGGGCGCGGAAGGGTGAGGGCGCCCGCCGCAGGAGGAGGTGCCGCTGCCGTGGCCGCCCGGCTGCCGGGAGCCGAC
AGCTTCGCGCCGGGGTTGTCTCCTCACAGACTATGAGCTCCTTGAAAGAGGGAATCGTGTCTTACTCATCTTTGTATCCCCAGTGTCTAG
CAGTTCCTGATACATAGTTTTAGCTGAATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTT
GCAGTTACAGGTAACTGTTTCTAGTGCCAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGG
AGAAATTACGAAAACAGCAAAATCCAGTAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATT
GGAATTTCAAGTTTGGAGCCATCGCACTTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACA
CAATAGAAAATGTGCTGTGATTGTCTCCACGCCCCAGGACATCGCATTGATGGATGCACACAAGGGTGCTGAGATGTTTCGCAGAGTCCA
CGTGCCCGTCCTTGGCCTTGTCCAAAACATGAGTGTTTTCCAGTGTCCAAAATGTAAACACAAAACTCATATTTTTGGTGCTGATGGTGC
AAGGAAACTAGCACAGACCCTTGGTCTTGAAGTTCTAGGAGACATTCCCTTACACCTTAATATAAGGGAAGCTTCAGATACAGGCCAGCC
AATTGTGTTTTCACAGCCTGAAAGTGATGAGGCCAAAGCTTACTTGAGGATTGCTGTGGAAGTGGTAAGAAGATTGCCATCACCTTCAGA
ATGATTCCCCAAGTGTCCTGGAAATTTGCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTACAGAAA
TAATAGAAATCATAACTGTTTTATTTCTAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCACAAAACTTTGATGTATCA
ATGTTAACTGCTATATTTAGGAATTTTTTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCATTTTATTTTATTGAATTACCCCTTTAG
AAATCACGAGTTTATGATGTTACAAGTCCATTTTGGGAGAGAACTGTACACTTTTTGCAGGACCACAGAATTAGTAATTTAAATGATATA
CTAAATTTGTGTATGGGCATAAGTATTACGCCTTCCCACCAGGCAATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACAT
GTTCTTAATATGAACCTCTGCTTCTTCATCTGGATCACACTATACCCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACAT
ATGTATTTTTAGTAAGACCATGATGATGTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTA
TAATTGTTCTTCCATTTGTGTGAGTGGGTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTG
AGTGTCTTGCTGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTTTGTACA
CCAATGTGCTTTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGTG
GGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTG
GTGGCATATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCATTTCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGAT
TGTACCACTGCACTCCAGCCTGGTCAATGGAGTGCGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATAT
TTAGCATTTCCTCAAACTTTTTTTGGCCATGAAATCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATA
CATTTTGAAAAACATTTATCTTGTCTAATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGC
TGCAAGTACTGATAAGTGTGAGCCATTAGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGC
TCTACAGTTGTCAACTAGAAAATTAGGCATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACATGTACATTGATGTTTATTG
CAATTTTATGTGTAATAACCAAAAACAACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTACATTCATACCGTGAGTGC
TACTCAGCAATAAAAAAGAACAAACTATGGGTACAGGCAGCAACTTATAATTCCAGAGAATTATGCTGAATGAAAAAGGCCAATTTAAAA
AGGTTTTGTACCAAAAGATTCCATTTATATAACGTTCTTGAAGTGACATAATTATAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAA
GGAGGGGGTGAGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAACATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTAT
CGATGTCAGTATCCCAGTTGTGATATTGTGCTATAGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGAAGGGCACATGGAATCTCT

>99517_99517_12_WWP1-NUBPL_WWP1_chr8_87393858_ENST00000517970_NUBPL_chr14_32295835_ENST00000536705_length(amino acids)=228AA_BP=112
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKA
DALLGKATIDLKQALLIHNRKCAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLGLEVL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for WWP1-NUBPL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for WWP1-NUBPL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for WWP1-NUBPL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source