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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WWP2-CIRH1A (FusionGDB2 ID:99523)

Fusion Gene Summary for WWP2-CIRH1A

check button Fusion gene summary
Fusion gene informationFusion gene name: WWP2-CIRH1A
Fusion gene ID: 99523
HgeneTgene
Gene symbol

WWP2

CIRH1A

Gene ID

11060

84916

Gene nameWW domain containing E3 ubiquitin protein ligase 2UTP4 small subunit processome component
SynonymsAIP2|WWp2-likeCIRH1A|CIRHIN|NAIC|TEX292
Cytomap

16q22.1

16q22.1

Type of geneprotein-codingprotein-coding
DescriptionNEDD4-like E3 ubiquitin-protein ligase WWP2HECT-type E3 ubiquitin transferase WWP2atrophin-1 interacting protein 2U3 small nucleolar RNA-associated protein 4 homologUTP4 small subunit (SSU) processome componentUTP4, small subunit (SSU) processome component, homologcirrhosis, autosomal recessive 1A (cirhin)testis expressed gene 292
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000544162, ENST00000356003, 
ENST00000359154, ENST00000448661, 
ENST00000542271, ENST00000569174, 
ENST00000568684, 		ENST00000314423, 
ENST00000352319, ENST00000563094, 
ENST00000569615, 
Fusion gene scores* DoF score18 X 16 X 11=31684 X 8 X 6=192
# samples 238
** MAII scorelog2(23/3168*10)=-3.78386656913523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WWP2 [Title/Abstract] AND CIRH1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCIRH1A(69184807)-WWP2(69963350), # samples:1
WWP2(69905834)-CIRH1A(69202724), # samples:1
Anticipated loss of major functional domain due to fusion event.CIRH1A-WWP2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
WWP2-CIRH1A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWP2

GO:0016567

protein ubiquitination

18776082|26280536

HgeneWWP2

GO:0032410

negative regulation of transporter activity

18776082

HgeneWWP2

GO:0034765

regulation of ion transmembrane transport

17289006

HgeneWWP2

GO:0042391

regulation of membrane potential

17289006

HgeneWWP2

GO:0051865

protein autoubiquitination

24105792

HgeneWWP2

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

TgeneCIRH1A

GO:0006355

regulation of transcription, DNA-templated

19732766


check buttonFusion gene breakpoints across WWP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CIRH1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01AWWP2chr16

69905834

+CIRH1Achr16

69202724

+


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Fusion Gene ORF analysis for WWP2-CIRH1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000544162ENST00000314423WWP2chr16

69905834

+CIRH1Achr16

69202724

+
3UTR-3CDSENST00000544162ENST00000352319WWP2chr16

69905834

+CIRH1Achr16

69202724

+
3UTR-intronENST00000544162ENST00000563094WWP2chr16

69905834

+CIRH1Achr16

69202724

+
3UTR-intronENST00000544162ENST00000569615WWP2chr16

69905834

+CIRH1Achr16

69202724

+
5CDS-intronENST00000356003ENST00000563094WWP2chr16

69905834

+CIRH1Achr16

69202724

+
5CDS-intronENST00000356003ENST00000569615WWP2chr16

69905834

+CIRH1Achr16

69202724

+
5CDS-intronENST00000359154ENST00000563094WWP2chr16

69905834

+CIRH1Achr16

69202724

+
5CDS-intronENST00000359154ENST00000569615WWP2chr16

69905834

+CIRH1Achr16

69202724

+
5CDS-intronENST00000448661ENST00000563094WWP2chr16

69905834

+CIRH1Achr16

69202724

+
5CDS-intronENST00000448661ENST00000569615WWP2chr16

69905834

+CIRH1Achr16

69202724

+
5CDS-intronENST00000542271ENST00000563094WWP2chr16

69905834

+CIRH1Achr16

69202724

+
5CDS-intronENST00000542271ENST00000569615WWP2chr16

69905834

+CIRH1Achr16

69202724

+
5CDS-intronENST00000569174ENST00000563094WWP2chr16

69905834

+CIRH1Achr16

69202724

+
5CDS-intronENST00000569174ENST00000569615WWP2chr16

69905834

+CIRH1Achr16

69202724

+
Frame-shiftENST00000356003ENST00000314423WWP2chr16

69905834

+CIRH1Achr16

69202724

+
Frame-shiftENST00000359154ENST00000314423WWP2chr16

69905834

+CIRH1Achr16

69202724

+
Frame-shiftENST00000448661ENST00000314423WWP2chr16

69905834

+CIRH1Achr16

69202724

+
Frame-shiftENST00000542271ENST00000314423WWP2chr16

69905834

+CIRH1Achr16

69202724

+
Frame-shiftENST00000569174ENST00000314423WWP2chr16

69905834

+CIRH1Achr16

69202724

+
In-frameENST00000356003ENST00000352319WWP2chr16

69905834

+CIRH1Achr16

69202724

+
In-frameENST00000359154ENST00000352319WWP2chr16

69905834

+CIRH1Achr16

69202724

+
In-frameENST00000448661ENST00000352319WWP2chr16

69905834

+CIRH1Achr16

69202724

+
In-frameENST00000542271ENST00000352319WWP2chr16

69905834

+CIRH1Achr16

69202724

+
In-frameENST00000569174ENST00000352319WWP2chr16

69905834

+CIRH1Achr16

69202724

+
intron-3CDSENST00000568684ENST00000314423WWP2chr16

69905834

+CIRH1Achr16

69202724

+
intron-3CDSENST00000568684ENST00000352319WWP2chr16

69905834

+CIRH1Achr16

69202724

+
intron-intronENST00000568684ENST00000563094WWP2chr16

69905834

+CIRH1Achr16

69202724

+
intron-intronENST00000568684ENST00000569615WWP2chr16

69905834

+CIRH1Achr16

69202724

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359154WWP2chr1669905834+ENST00000352319CIRH1Achr1669202724+100480471832253
ENST00000448661WWP2chr1669905834+ENST00000352319CIRH1Achr1669202724+98178178809243
ENST00000569174WWP2chr1669905834+ENST00000352319CIRH1Achr1669202724+97377370801243
ENST00000356003WWP2chr1669905834+ENST00000352319CIRH1Achr1669202724+92972926757243
ENST00000542271WWP2chr1669905834+ENST00000352319CIRH1Achr1669202724+716516507109132

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359154ENST00000352319WWP2chr1669905834+CIRH1Achr1669202724+0.0623902340.9376098
ENST00000448661ENST00000352319WWP2chr1669905834+CIRH1Achr1669202724+0.071692040.9283079
ENST00000569174ENST00000352319WWP2chr1669905834+CIRH1Achr1669202724+0.073753680.9262463
ENST00000356003ENST00000352319WWP2chr1669905834+CIRH1Achr1669202724+0.074879620.9251204
ENST00000542271ENST00000352319WWP2chr1669905834+CIRH1Achr1669202724+0.163785370.8362146

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Fusion Genomic Features for WWP2-CIRH1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WWP2chr1669905834+CIRH1Achr1669202723+3.54E-050.9999646
WWP2chr1669905834+CIRH1Achr1669202723+3.54E-050.9999646

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for WWP2-CIRH1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:69184807/chr16:69963350)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWP2chr16:69905834chr16:69202724ENST00000356003+6231_117234871.0DomainC2
HgeneWWP2chr16:69905834chr16:69202724ENST00000359154+7241_117234871.0DomainC2
HgeneWWP2chr16:69905834chr16:69202724ENST00000448661+7241_117234871.0DomainC2
HgeneWWP2chr16:69905834chr16:69202724ENST00000542271+4211_117118755.0DomainC2
HgeneWWP2chr16:69905834chr16:69202724ENST00000569174+791_117234336.0DomainC2
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003523191214567_627533572.0RepeatNote=WD 13
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003523191214628_666533572.0RepeatNote=WD 14
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000563094015136_1810626.0RepeatNote=WD 4
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000563094015182_2260626.0RepeatNote=WD 5
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000563094015227_2750626.0RepeatNote=WD 6
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000563094015276_3170626.0RepeatNote=WD 7
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000563094015318_3770626.0RepeatNote=WD 8
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000563094015378_4270626.0RepeatNote=WD 9
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000563094015428_4750626.0RepeatNote=WD 10
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000563094015476_5160626.0RepeatNote=WD 11
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000563094015517_5660626.0RepeatNote=WD 12
TgeneCIRH1Achr16:69905834chr16:69202724ENST0000056309401551_920626.0RepeatNote=WD 2
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000563094015567_6270626.0RepeatNote=WD 13
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000563094015628_6660626.0RepeatNote=WD 14
TgeneCIRH1Achr16:69905834chr16:69202724ENST000005630940157_500626.0RepeatNote=WD 1
TgeneCIRH1Achr16:69905834chr16:69202724ENST0000056309401593_1350626.0RepeatNote=WD 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWP2chr16:69905834chr16:69202724ENST00000356003+623300_333234871.0DomainWW 1
HgeneWWP2chr16:69905834chr16:69202724ENST00000356003+623330_363234871.0DomainWW 2
HgeneWWP2chr16:69905834chr16:69202724ENST00000356003+623405_437234871.0DomainWW 3
HgeneWWP2chr16:69905834chr16:69202724ENST00000356003+623444_477234871.0DomainWW 4
HgeneWWP2chr16:69905834chr16:69202724ENST00000356003+623536_870234871.0DomainHECT
HgeneWWP2chr16:69905834chr16:69202724ENST00000359154+724300_333234871.0DomainWW 1
HgeneWWP2chr16:69905834chr16:69202724ENST00000359154+724330_363234871.0DomainWW 2
HgeneWWP2chr16:69905834chr16:69202724ENST00000359154+724405_437234871.0DomainWW 3
HgeneWWP2chr16:69905834chr16:69202724ENST00000359154+724444_477234871.0DomainWW 4
HgeneWWP2chr16:69905834chr16:69202724ENST00000359154+724536_870234871.0DomainHECT
HgeneWWP2chr16:69905834chr16:69202724ENST00000448661+724300_333234871.0DomainWW 1
HgeneWWP2chr16:69905834chr16:69202724ENST00000448661+724330_363234871.0DomainWW 2
HgeneWWP2chr16:69905834chr16:69202724ENST00000448661+724405_437234871.0DomainWW 3
HgeneWWP2chr16:69905834chr16:69202724ENST00000448661+724444_477234871.0DomainWW 4
HgeneWWP2chr16:69905834chr16:69202724ENST00000448661+724536_870234871.0DomainHECT
HgeneWWP2chr16:69905834chr16:69202724ENST00000542271+421300_333118755.0DomainWW 1
HgeneWWP2chr16:69905834chr16:69202724ENST00000542271+421330_363118755.0DomainWW 2
HgeneWWP2chr16:69905834chr16:69202724ENST00000542271+421405_437118755.0DomainWW 3
HgeneWWP2chr16:69905834chr16:69202724ENST00000542271+421444_477118755.0DomainWW 4
HgeneWWP2chr16:69905834chr16:69202724ENST00000542271+421536_870118755.0DomainHECT
HgeneWWP2chr16:69905834chr16:69202724ENST00000568684+1141_1170432.0DomainC2
HgeneWWP2chr16:69905834chr16:69202724ENST00000568684+114300_3330432.0DomainWW 1
HgeneWWP2chr16:69905834chr16:69202724ENST00000568684+114330_3630432.0DomainWW 2
HgeneWWP2chr16:69905834chr16:69202724ENST00000568684+114405_4370432.0DomainWW 3
HgeneWWP2chr16:69905834chr16:69202724ENST00000568684+114444_4770432.0DomainWW 4
HgeneWWP2chr16:69905834chr16:69202724ENST00000568684+114536_8700432.0DomainHECT
HgeneWWP2chr16:69905834chr16:69202724ENST00000569174+79300_333234336.0DomainWW 1
HgeneWWP2chr16:69905834chr16:69202724ENST00000569174+79330_363234336.0DomainWW 2
HgeneWWP2chr16:69905834chr16:69202724ENST00000569174+79405_437234336.0DomainWW 3
HgeneWWP2chr16:69905834chr16:69202724ENST00000569174+79444_477234336.0DomainWW 4
HgeneWWP2chr16:69905834chr16:69202724ENST00000569174+79536_870234336.0DomainHECT
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003144231517136_181648687.0RepeatNote=WD 4
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003144231517182_226648687.0RepeatNote=WD 5
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003144231517227_275648687.0RepeatNote=WD 6
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003144231517276_317648687.0RepeatNote=WD 7
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003144231517318_377648687.0RepeatNote=WD 8
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003144231517378_427648687.0RepeatNote=WD 9
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003144231517428_475648687.0RepeatNote=WD 10
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003144231517476_516648687.0RepeatNote=WD 11
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003144231517517_566648687.0RepeatNote=WD 12
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000314423151751_92648687.0RepeatNote=WD 2
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003144231517567_627648687.0RepeatNote=WD 13
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003144231517628_666648687.0RepeatNote=WD 14
TgeneCIRH1Achr16:69905834chr16:69202724ENST0000031442315177_50648687.0RepeatNote=WD 1
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000314423151793_135648687.0RepeatNote=WD 3
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003523191214136_181533572.0RepeatNote=WD 4
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003523191214182_226533572.0RepeatNote=WD 5
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003523191214227_275533572.0RepeatNote=WD 6
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003523191214276_317533572.0RepeatNote=WD 7
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003523191214318_377533572.0RepeatNote=WD 8
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003523191214378_427533572.0RepeatNote=WD 9
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003523191214428_475533572.0RepeatNote=WD 10
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003523191214476_516533572.0RepeatNote=WD 11
TgeneCIRH1Achr16:69905834chr16:69202724ENST000003523191214517_566533572.0RepeatNote=WD 12
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000352319121451_92533572.0RepeatNote=WD 2
TgeneCIRH1Achr16:69905834chr16:69202724ENST0000035231912147_50533572.0RepeatNote=WD 1
TgeneCIRH1Achr16:69905834chr16:69202724ENST00000352319121493_135533572.0RepeatNote=WD 3


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Fusion Gene Sequence for WWP2-CIRH1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99523_99523_1_WWP2-CIRH1A_WWP2_chr16_69905834_ENST00000356003_CIRH1A_chr16_69202724_ENST00000352319_length(transcript)=929nt_BP=729nt
TTGTCTTACAGCTTCACGGTGATGATATGGCATCTGCCAGCTCTAGCCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTT
TGAAAGTGGTGTCCGCAAAGCCCAAGGTGCATAATCGTCAACCTCGAATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTG
AGACCAAGAAGACTGGGAAGCGCATTGGGAGCTCTGAGCTTCTCTGGAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAG
ATTTAAAGGTCTGGAGCTGCCATACCTTGAGAAATGAACTGCTAGGCACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGG
GCAAAATGGAGAACATGCAGCTGACCCTGAACCTGCAGACGGAGAACAAAGGCAGCGTTGTCTCAGGCGGAGAGCTGACAATTTTCCTGG
ACGGGCCAACTGTTGATCTGGGAAATGTGCCTAATGGCAGTGCCCTGACAGATGGATCACAGCTGCCTTCGAGAGACTCCAGTGGAACAG
CAGTAGCTCCAGAGAACCGGCACCAGCCCCCCAGCACAAACTGCTTTGGTGGAAGATCCCGGACGCACAGACATTCGGGTGCTTCAGCCA
GAACAACCCCAGCAACCGGCGAGCAAAGCCCCGGTGCTCGGAGCCGGCACCGCCAGCCCGTCAAGAACTCAGGCCACAGTGGCTTGGCCA
ATGGCACAGCCTCTACTCTTCATGGATCTTTTGGATGAAAGAACACTCGTGGCAGTAGAACGGCCTCTGGATGACATCATTGCTCAGCTC
CCACCACCCATTAAAAAGAAGAAATTTGGAACCTAAAACAGGGCACTGTCTGTGTCCTTCCTTGAACTGTCTACCCTGTTGCTTTTCACA

>99523_99523_1_WWP2-CIRH1A_WWP2_chr16_69905834_ENST00000356003_CIRH1A_chr16_69202724_ENST00000352319_length(amino acids)=243AA_BP=
MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSHLDLKVWSCHT
LRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ

--------------------------------------------------------------
>99523_99523_2_WWP2-CIRH1A_WWP2_chr16_69905834_ENST00000359154_CIRH1A_chr16_69202724_ENST00000352319_length(transcript)=1004nt_BP=804nt
GCGCGGTCACGTGACCCGGCCCGAGTGCGGGCGGTGGAAGGCGGAAGTAGGAGAGGAGTTCGGCGCCGCTTCTGTGGCCACGGCAGCTTC
ACGGTGATGATATGGCATCTGCCAGCTCTAGCCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTTTGAAAGTGGTGTCCG
CAAAGCCCAAGGTGCATAATCGTCAACCTCGAATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTGAGACCAAGAAGACTG
GGAAGCGCATTGGGAGCTCTGAGCTTCTCTGGAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAGATTTAAAGGTCTGGA
GCTGCCATACCTTGAGAAATGAACTGCTAGGCACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGGGCAAAATGGAGAACA
TGCAGCTGACCCTGAACCTGCAGACGGAGAACAAAGGCAGCGTTGTCTCAGGCGGAGAGCTGACAATTTTCCTGGACGGGCCAACTGTTG
ATCTGGGAAATGTGCCTAATGGCAGTGCCCTGACAGATGGATCACAGCTGCCTTCGAGAGACTCCAGTGGAACAGCAGTAGCTCCAGAGA
ACCGGCACCAGCCCCCCAGCACAAACTGCTTTGGTGGAAGATCCCGGACGCACAGACATTCGGGTGCTTCAGCCAGAACAACCCCAGCAA
CCGGCGAGCAAAGCCCCGGTGCTCGGAGCCGGCACCGCCAGCCCGTCAAGAACTCAGGCCACAGTGGCTTGGCCAATGGCACAGCCTCTA
CTCTTCATGGATCTTTTGGATGAAAGAACACTCGTGGCAGTAGAACGGCCTCTGGATGACATCATTGCTCAGCTCCCACCACCCATTAAA
AAGAAGAAATTTGGAACCTAAAACAGGGCACTGTCTGTGTCCTTCCTTGAACTGTCTACCCTGTTGCTTTTCACAAATCATGGTAATAAA

>99523_99523_2_WWP2-CIRH1A_WWP2_chr16_69905834_ENST00000359154_CIRH1A_chr16_69202724_ENST00000352319_length(amino acids)=253AA_BP=
MWPRQLHGDDMASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSH
LDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSG

--------------------------------------------------------------
>99523_99523_3_WWP2-CIRH1A_WWP2_chr16_69905834_ENST00000448661_CIRH1A_chr16_69202724_ENST00000352319_length(transcript)=981nt_BP=781nt
TTCGGCGCCGCTTCTGTGGCCACGGCAGGTAGCGAGCGCTGGCGCGGGGGGCGCGTCTTACAGCTTCACGGTGATGATATGGCATCTGCC
AGCTCTAGCCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTTTGAAAGTGGTGTCCGCAAAGCCCAAGGTGCATAATCGT
CAACCTCGAATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTGAGACCAAGAAGACTGGGAAGCGCATTGGGAGCTCTGAG
CTTCTCTGGAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAGATTTAAAGGTCTGGAGCTGCCATACCTTGAGAAATGAA
CTGCTAGGCACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGGGCAAAATGGAGAACATGCAGCTGACCCTGAACCTGCAG
ACGGAGAACAAAGGCAGCGTTGTCTCAGGCGGAGAGCTGACAATTTTCCTGGACGGGCCAACTGTTGATCTGGGAAATGTGCCTAATGGC
AGTGCCCTGACAGATGGATCACAGCTGCCTTCGAGAGACTCCAGTGGAACAGCAGTAGCTCCAGAGAACCGGCACCAGCCCCCCAGCACA
AACTGCTTTGGTGGAAGATCCCGGACGCACAGACATTCGGGTGCTTCAGCCAGAACAACCCCAGCAACCGGCGAGCAAAGCCCCGGTGCT
CGGAGCCGGCACCGCCAGCCCGTCAAGAACTCAGGCCACAGTGGCTTGGCCAATGGCACAGCCTCTACTCTTCATGGATCTTTTGGATGA
AAGAACACTCGTGGCAGTAGAACGGCCTCTGGATGACATCATTGCTCAGCTCCCACCACCCATTAAAAAGAAGAAATTTGGAACCTAAAA

>99523_99523_3_WWP2-CIRH1A_WWP2_chr16_69905834_ENST00000448661_CIRH1A_chr16_69202724_ENST00000352319_length(amino acids)=243AA_BP=
MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSHLDLKVWSCHT
LRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ

--------------------------------------------------------------
>99523_99523_4_WWP2-CIRH1A_WWP2_chr16_69905834_ENST00000542271_CIRH1A_chr16_69202724_ENST00000352319_length(transcript)=716nt_BP=516nt
ATTTTATAGAAACGTTTAGTACTCACCAAGGCCCTCAGTGGAACTGGCTGAAAATAGCAGCAGACTCACTCAGAAAAGAATTGGAGAGAT
CCATGGCAGGGAAGAGAGATTAAGGGAAGGTAGAGCGCTTAGGAGAGCTTGAAAACCCAAAGGTGGAGAACATGCAGCTGACCCTGAACC
TGCAGACGGAGAACAAAGGCAGCGTTGTCTCAGGCGGAGAGCTGACAATTTTCCTGGACGGGCCAACTGTTGATCTGGGAAATGTGCCTA
ATGGCAGTGCCCTGACAGATGGATCACAGCTGCCTTCGAGAGACTCCAGTGGAACAGCAGTAGCTCCAGAGAACCGGCACCAGCCCCCCA
GCACAAACTGCTTTGGTGGAAGATCCCGGACGCACAGACATTCGGGTGCTTCAGCCAGAACAACCCCAGCAACCGGCGAGCAAAGCCCCG
GTGCTCGGAGCCGGCACCGCCAGCCCGTCAAGAACTCAGGCCACAGTGGCTTGGCCAATGGCACAGCCTCTACTCTTCATGGATCTTTTG
GATGAAAGAACACTCGTGGCAGTAGAACGGCCTCTGGATGACATCATTGCTCAGCTCCCACCACCCATTAAAAAGAAGAAATTTGGAACC

>99523_99523_4_WWP2-CIRH1A_WWP2_chr16_69905834_ENST00000542271_CIRH1A_chr16_69202724_ENST00000352319_length(amino acids)=132AA_BP=
MAKPLWPEFLTGWRCRLRAPGLCSPVAGVVLAEAPECLCVRDLPPKQFVLGGWCRFSGATAVPLESLEGSCDPSVRALPLGTFPRSTVGP

--------------------------------------------------------------
>99523_99523_5_WWP2-CIRH1A_WWP2_chr16_69905834_ENST00000569174_CIRH1A_chr16_69202724_ENST00000352319_length(transcript)=973nt_BP=773nt
AGATGAAACAGAAAGGCTAAAGAGGGCTGGAGTCAGGGGACTTCTCTTCCACCAGCTTCACGGTGATGATATGGCATCTGCCAGCTCTAG
CCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTTTGAAAGTGGTGTCCGCAAAGCCCAAGGTGCATAATCGTCAACCTCG
AATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTGAGACCAAGAAGACTGGGAAGCGCATTGGGAGCTCTGAGCTTCTCTG
GAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAGATTTAAAGGTCTGGAGCTGCCATACCTTGAGAAATGAACTGCTAGG
CACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGGGCAAAATGGAGAACATGCAGCTGACCCTGAACCTGCAGACGGAGAA
CAAAGGCAGCGTTGTCTCAGGCGGAGAGCTGACAATTTTCCTGGACGGGCCAACTGTTGATCTGGGAAATGTGCCTAATGGCAGTGCCCT
GACAGATGGATCACAGCTGCCTTCGAGAGACTCCAGTGGAACAGCAGTAGCTCCAGAGAACCGGCACCAGCCCCCCAGCACAAACTGCTT
TGGTGGAAGATCCCGGACGCACAGACATTCGGGTGCTTCAGCCAGAACAACCCCAGCAACCGGCGAGCAAAGCCCCGGTGCTCGGAGCCG
GCACCGCCAGCCCGTCAAGAACTCAGGCCACAGTGGCTTGGCCAATGGCACAGCCTCTACTCTTCATGGATCTTTTGGATGAAAGAACAC
TCGTGGCAGTAGAACGGCCTCTGGATGACATCATTGCTCAGCTCCCACCACCCATTAAAAAGAAGAAATTTGGAACCTAAAACAGGGCAC

>99523_99523_5_WWP2-CIRH1A_WWP2_chr16_69905834_ENST00000569174_CIRH1A_chr16_69202724_ENST00000352319_length(amino acids)=243AA_BP=
MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSHLDLKVWSCHT
LRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WWP2-CIRH1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WWP2-CIRH1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WWP2-CIRH1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource