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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WWP2-CTSB (FusionGDB2 ID:99524)

Fusion Gene Summary for WWP2-CTSB

check button Fusion gene summary
Fusion gene informationFusion gene name: WWP2-CTSB
Fusion gene ID: 99524
HgeneTgene
Gene symbol

WWP2

CTSB

Gene ID

11060

1508

Gene nameWW domain containing E3 ubiquitin protein ligase 2cathepsin B
SynonymsAIP2|WWp2-likeAPPS|CPSB|RECEUP
Cytomap

16q22.1

8p23.1

Type of geneprotein-codingprotein-coding
DescriptionNEDD4-like E3 ubiquitin-protein ligase WWP2HECT-type E3 ubiquitin transferase WWP2atrophin-1 interacting protein 2cathepsin BAPP secretaseamyloid precursor protein secretasecathepsin B1cysteine proteaseepididymis secretory sperm binding protein
Modification date2020032720200313
UniProtAcc.

P07858

Ensembl transtripts involved in fusion geneENST00000544162, ENST00000356003, 
ENST00000359154, ENST00000448661, 
ENST00000542271, ENST00000568684, 
ENST00000569174, 		ENST00000353047, 
ENST00000434271, ENST00000453527, 
ENST00000530640, ENST00000531089, 
ENST00000345125, ENST00000415599, 
ENST00000533455, ENST00000534510, 
ENST00000525076, 
Fusion gene scores* DoF score18 X 16 X 11=316813 X 14 X 6=1092
# samples 2314
** MAII scorelog2(23/3168*10)=-3.78386656913523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1092*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WWP2 [Title/Abstract] AND CTSB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWWP2(69973809)-CTSB(11705230), # samples:1
Anticipated loss of major functional domain due to fusion event.WWP2-CTSB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WWP2-CTSB seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWP2

GO:0016567

protein ubiquitination

18776082|26280536

HgeneWWP2

GO:0032410

negative regulation of transporter activity

18776082

HgeneWWP2

GO:0034765

regulation of ion transmembrane transport

17289006

HgeneWWP2

GO:0042391

regulation of membrane potential

17289006

HgeneWWP2

GO:0051865

protein autoubiquitination

24105792

HgeneWWP2

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

TgeneCTSB

GO:0006508

proteolysis

7890620|8811434

TgeneCTSB

GO:0030574

collagen catabolic process

22952693

TgeneCTSB

GO:0051603

proteolysis involved in cellular protein catabolic process

22952693


check buttonFusion gene breakpoints across WWP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CTSB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-EM-A2OX-01AWWP2chr16

69973809

+CTSBchr8

11705230

-


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Fusion Gene ORF analysis for WWP2-CTSB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000544162ENST00000353047WWP2chr16

69973809

+CTSBchr8

11705230

-
3UTR-3CDSENST00000544162ENST00000434271WWP2chr16

69973809

+CTSBchr8

11705230

-
3UTR-3CDSENST00000544162ENST00000453527WWP2chr16

69973809

+CTSBchr8

11705230

-
3UTR-3CDSENST00000544162ENST00000530640WWP2chr16

69973809

+CTSBchr8

11705230

-
3UTR-3CDSENST00000544162ENST00000531089WWP2chr16

69973809

+CTSBchr8

11705230

-
3UTR-3UTRENST00000544162ENST00000345125WWP2chr16

69973809

+CTSBchr8

11705230

-
3UTR-3UTRENST00000544162ENST00000415599WWP2chr16

69973809

+CTSBchr8

11705230

-
3UTR-3UTRENST00000544162ENST00000533455WWP2chr16

69973809

+CTSBchr8

11705230

-
3UTR-3UTRENST00000544162ENST00000534510WWP2chr16

69973809

+CTSBchr8

11705230

-
3UTR-intronENST00000544162ENST00000525076WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000356003ENST00000345125WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000356003ENST00000415599WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000356003ENST00000533455WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000356003ENST00000534510WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000359154ENST00000345125WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000359154ENST00000415599WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000359154ENST00000533455WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000359154ENST00000534510WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000448661ENST00000345125WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000448661ENST00000415599WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000448661ENST00000533455WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000448661ENST00000534510WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000542271ENST00000345125WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000542271ENST00000415599WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000542271ENST00000533455WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000542271ENST00000534510WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000568684ENST00000345125WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000568684ENST00000415599WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000568684ENST00000533455WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-3UTRENST00000568684ENST00000534510WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-intronENST00000356003ENST00000525076WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-intronENST00000359154ENST00000525076WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-intronENST00000448661ENST00000525076WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-intronENST00000542271ENST00000525076WWP2chr16

69973809

+CTSBchr8

11705230

-
5CDS-intronENST00000568684ENST00000525076WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000356003ENST00000353047WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000356003ENST00000434271WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000356003ENST00000453527WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000356003ENST00000530640WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000356003ENST00000531089WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000448661ENST00000353047WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000448661ENST00000434271WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000448661ENST00000453527WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000448661ENST00000530640WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000448661ENST00000531089WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000542271ENST00000353047WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000542271ENST00000434271WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000542271ENST00000453527WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000542271ENST00000530640WWP2chr16

69973809

+CTSBchr8

11705230

-
Frame-shiftENST00000542271ENST00000531089WWP2chr16

69973809

+CTSBchr8

11705230

-
In-frameENST00000359154ENST00000353047WWP2chr16

69973809

+CTSBchr8

11705230

-
In-frameENST00000359154ENST00000434271WWP2chr16

69973809

+CTSBchr8

11705230

-
In-frameENST00000359154ENST00000453527WWP2chr16

69973809

+CTSBchr8

11705230

-
In-frameENST00000359154ENST00000530640WWP2chr16

69973809

+CTSBchr8

11705230

-
In-frameENST00000359154ENST00000531089WWP2chr16

69973809

+CTSBchr8

11705230

-
In-frameENST00000568684ENST00000353047WWP2chr16

69973809

+CTSBchr8

11705230

-
In-frameENST00000568684ENST00000434271WWP2chr16

69973809

+CTSBchr8

11705230

-
In-frameENST00000568684ENST00000453527WWP2chr16

69973809

+CTSBchr8

11705230

-
In-frameENST00000568684ENST00000530640WWP2chr16

69973809

+CTSBchr8

11705230

-
In-frameENST00000568684ENST00000531089WWP2chr16

69973809

+CTSBchr8

11705230

-
intron-3CDSENST00000569174ENST00000353047WWP2chr16

69973809

+CTSBchr8

11705230

-
intron-3CDSENST00000569174ENST00000434271WWP2chr16

69973809

+CTSBchr8

11705230

-
intron-3CDSENST00000569174ENST00000453527WWP2chr16

69973809

+CTSBchr8

11705230

-
intron-3CDSENST00000569174ENST00000530640WWP2chr16

69973809

+CTSBchr8

11705230

-
intron-3CDSENST00000569174ENST00000531089WWP2chr16

69973809

+CTSBchr8

11705230

-
intron-3UTRENST00000569174ENST00000345125WWP2chr16

69973809

+CTSBchr8

11705230

-
intron-3UTRENST00000569174ENST00000415599WWP2chr16

69973809

+CTSBchr8

11705230

-
intron-3UTRENST00000569174ENST00000533455WWP2chr16

69973809

+CTSBchr8

11705230

-
intron-3UTRENST00000569174ENST00000534510WWP2chr16

69973809

+CTSBchr8

11705230

-
intron-intronENST00000569174ENST00000525076WWP2chr16

69973809

+CTSBchr8

11705230

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359154WWP2chr1669973809+ENST00000434271CTSBchr811705230-74374449712647858
ENST00000359154WWP2chr1669973809+ENST00000353047CTSBchr811705230-74374449712647858
ENST00000359154WWP2chr1669973809+ENST00000530640CTSBchr811705230-50684449712647858
ENST00000359154WWP2chr1669973809+ENST00000531089CTSBchr811705230-50274449712647858
ENST00000359154WWP2chr1669973809+ENST00000453527CTSBchr811705230-56414449712647858
ENST00000568684WWP2chr1669973809+ENST00000434271CTSBchr811705230-659436064701807445
ENST00000568684WWP2chr1669973809+ENST00000353047CTSBchr811705230-659436064701807445
ENST00000568684WWP2chr1669973809+ENST00000530640CTSBchr811705230-422536064701807445
ENST00000568684WWP2chr1669973809+ENST00000531089CTSBchr811705230-418436064701807445
ENST00000568684WWP2chr1669973809+ENST00000453527CTSBchr811705230-479836064701807445

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359154ENST00000434271WWP2chr1669973809+CTSBchr811705230-0.0027294630.9972705
ENST00000359154ENST00000353047WWP2chr1669973809+CTSBchr811705230-0.0027294630.9972705
ENST00000359154ENST00000530640WWP2chr1669973809+CTSBchr811705230-0.0043533840.99564654
ENST00000359154ENST00000531089WWP2chr1669973809+CTSBchr811705230-0.0042062880.9957937
ENST00000359154ENST00000453527WWP2chr1669973809+CTSBchr811705230-0.0030959880.99690396
ENST00000568684ENST00000434271WWP2chr1669973809+CTSBchr811705230-0.0040269470.99597305
ENST00000568684ENST00000353047WWP2chr1669973809+CTSBchr811705230-0.0040269470.99597305
ENST00000568684ENST00000530640WWP2chr1669973809+CTSBchr811705230-0.0050975570.9949025
ENST00000568684ENST00000531089WWP2chr1669973809+CTSBchr811705230-0.005014880.9949851
ENST00000568684ENST00000453527WWP2chr1669973809+CTSBchr811705230-0.0041750890.99582493

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Fusion Genomic Features for WWP2-CTSB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WWP2-CTSB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:69973809/chr8:11705230)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CTSB

P07858

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:12220505, ECO:0000269|PubMed:3972105}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWP2chr16:69973809chr8:11705230ENST00000356003+1231_1170871.0DomainC2
HgeneWWP2chr16:69973809chr8:11705230ENST00000356003+123300_3330871.0DomainWW 1
HgeneWWP2chr16:69973809chr8:11705230ENST00000356003+123330_3630871.0DomainWW 2
HgeneWWP2chr16:69973809chr8:11705230ENST00000356003+123405_4370871.0DomainWW 3
HgeneWWP2chr16:69973809chr8:11705230ENST00000356003+123444_4770871.0DomainWW 4
HgeneWWP2chr16:69973809chr8:11705230ENST00000356003+123536_8700871.0DomainHECT
HgeneWWP2chr16:69973809chr8:11705230ENST00000359154+1241_1170871.0DomainC2
HgeneWWP2chr16:69973809chr8:11705230ENST00000359154+124300_3330871.0DomainWW 1
HgeneWWP2chr16:69973809chr8:11705230ENST00000359154+124330_3630871.0DomainWW 2
HgeneWWP2chr16:69973809chr8:11705230ENST00000359154+124405_4370871.0DomainWW 3
HgeneWWP2chr16:69973809chr8:11705230ENST00000359154+124444_4770871.0DomainWW 4
HgeneWWP2chr16:69973809chr8:11705230ENST00000359154+124536_8700871.0DomainHECT
HgeneWWP2chr16:69973809chr8:11705230ENST00000448661+1241_1170871.0DomainC2
HgeneWWP2chr16:69973809chr8:11705230ENST00000448661+124300_3330871.0DomainWW 1
HgeneWWP2chr16:69973809chr8:11705230ENST00000448661+124330_3630871.0DomainWW 2
HgeneWWP2chr16:69973809chr8:11705230ENST00000448661+124405_4370871.0DomainWW 3
HgeneWWP2chr16:69973809chr8:11705230ENST00000448661+124444_4770871.0DomainWW 4
HgeneWWP2chr16:69973809chr8:11705230ENST00000448661+124536_8700871.0DomainHECT
HgeneWWP2chr16:69973809chr8:11705230ENST00000542271+1211_1170755.0DomainC2
HgeneWWP2chr16:69973809chr8:11705230ENST00000542271+121300_3330755.0DomainWW 1
HgeneWWP2chr16:69973809chr8:11705230ENST00000542271+121330_3630755.0DomainWW 2
HgeneWWP2chr16:69973809chr8:11705230ENST00000542271+121405_4370755.0DomainWW 3
HgeneWWP2chr16:69973809chr8:11705230ENST00000542271+121444_4770755.0DomainWW 4
HgeneWWP2chr16:69973809chr8:11705230ENST00000542271+121536_8700755.0DomainHECT
HgeneWWP2chr16:69973809chr8:11705230ENST00000568684+1141_1170432.0DomainC2
HgeneWWP2chr16:69973809chr8:11705230ENST00000568684+114300_3330432.0DomainWW 1
HgeneWWP2chr16:69973809chr8:11705230ENST00000568684+114330_3630432.0DomainWW 2
HgeneWWP2chr16:69973809chr8:11705230ENST00000568684+114405_4370432.0DomainWW 3
HgeneWWP2chr16:69973809chr8:11705230ENST00000568684+114444_4770432.0DomainWW 4
HgeneWWP2chr16:69973809chr8:11705230ENST00000568684+114536_8700432.0DomainHECT
HgeneWWP2chr16:69973809chr8:11705230ENST00000569174+191_1170336.0DomainC2
HgeneWWP2chr16:69973809chr8:11705230ENST00000569174+19300_3330336.0DomainWW 1
HgeneWWP2chr16:69973809chr8:11705230ENST00000569174+19330_3630336.0DomainWW 2
HgeneWWP2chr16:69973809chr8:11705230ENST00000569174+19405_4370336.0DomainWW 3
HgeneWWP2chr16:69973809chr8:11705230ENST00000569174+19444_4770336.0DomainWW 4
HgeneWWP2chr16:69973809chr8:11705230ENST00000569174+19536_8700336.0DomainHECT


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Fusion Gene Sequence for WWP2-CTSB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99524_99524_1_WWP2-CTSB_WWP2_chr16_69973809_ENST00000359154_CTSB_chr8_11705230_ENST00000353047_length(transcript)=7437nt_BP=4449nt
GCGCGGTCACGTGACCCGGCCCGAGTGCGGGCGGTGGAAGGCGGAAGTAGGAGAGGAGTTCGGCGCCGCTTCTGTGGCCACGGCAGCTTC
ACGGTGATGATATGGCATCTGCCAGCTCTAGCCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTTTGAAAGTGGTGTCCG
CAAAGCCCAAGGTGCATAATCGTCAACCTCGAATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTGAGACCAAGAAGACTG
GGAAGCGCATTGGGAGCTCTGAGCTTCTCTGGAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAGATTTAAAGGTCTGGA
GCTGCCATACCTTGAGAAATGAACTGCTAGGCACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGGGCAAAATGGAGAACA
TGCAGCTGACCCTGAACCTGCAGACGGAGAACAAAGGCAGCGTTGTCTCAGGCGGAGAGCTGACAATTTTCCTGGACGGGCCAACTGTTG
ATCTGGGAAATGTGCCTAATGGCAGTGCCCTGACAGATGGATCACAGCTGCCTTCGAGAGACTCCAGTGGAACAGCAGTAGCTCCAGAGA
ACCGGCACCAGCCCCCCAGCACAAACTGCTTTGGTGGAAGATCCCGGACGCACAGACATTCGGGTGCTTCAGCCAGAACAACCCCAGCAA
CCGGCGAGCAAAGCCCCGGTGCTCGGAGCCGGCACCGCCAGCCCGTCAAGAACTCAGGCCACAGTGGCTTGGCCAATGGCACAGTGAATG
ATGAACCCACAACAGCCACTGATCCCGAAGAACCTTCCGTTGTTGGTGTGACGTCCCCACCTGCTGCACCCTTGAGTGTGACCCCGAATC
CCAACACGACTTCTCTCCCTGCCCCAGCCACACCGGCTGAAGGAGAGGAACCCAGCACTTCGGGTACACAGCAGCTCCCAGCGGCTGCCC
AGGCCCCCGACGCTCTGCCTGCTGGATGGGAACAGCGAGAGCTGCCCAACGGACGTGTCTATTATGTTGACCACAATACCAAGACCACCA
CCTGGGAGCGGCCCCTTCCTCCAGGCTGGGAAAAACGCACAGATCCCCGAGGCAGGTTTTACTATGTGGATCACAATACTCGGACCACCA
CCTGGCAGCGTCCGACCGCGGAGTACGTGCGCAACTATGAGCAGTGGCAGTCGCAGCGGAATCAGCTCCAGGGGGCCATGCAGCACTTCA
GCCAAAGATTCCTCTACCAGTCTTCGAGTGCTTCGACTGACCATGATCCCCTGGGCCCCCTCCCTCCTGGCTGGGAGAAGAGACAGGACA
ATGGACGGGTGTATTACGTGAACCATAACACTCGCACGACCCAGTGGGAGGATCCCCGGACCCAGGGGATGATCCAGGAACCAGCTCTGC
CCCCAGGATGGGAGATGAAATACACCAGCGAGGGGGTGCGATACTTTGTGGACCACAATACCCGCACCACCACCTTTAAGGATCCTCGCC
CGGGGTTTGAGTCGGGGACGAAGCAAGGTTCCCCTGGTGCTTATGACCGCAGTTTTCGGTGGAAGTATCACCAGTTCCGTTTCCTCTGCC
ATTCAAATGCCCTACCTAGCCACGTGAAGATCAGCGTTTCCAGGCAGACGCTTTTCGAAGATTCCTTCCAACAGATCATGAACATGAAAC
CCTATGACCTGCGCCGCCGGCTCTACATCATCATGCGTGGCGAGGAGGGCCTGGACTATGGGGGCATCGCCAGAGAGTGGTTTTTCCTCC
TGTCTCATGAGGTGCTCAACCCTATGTATTGTTTATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCA
TCAACCCGGACCACCTCACCTACTTTCGCTTTATAGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCA
CCCTCCCTTTCTACAAGCGGATGCTCAATAAGAGACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCT
GGATCAAAGAGAACAACCTGGAAGAATGTGGCCTGGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGC
TGAAGGAGGGCGGCGAGAGCATCCGGGTCACAGAGGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCG
TGGAAGAGCAGACCAAAGCCTTCCTGGATGGCTTCAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGC
TGATGCTGTGCGGCATGCAGGAGATAGACATGAGCGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCC
AGTGGTTCTGGCAGGTGGTGAAGGAGATGGACAACGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCG
GGGGATTTGCCGAACTCATCGGTAGCAACGGACCACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACA
CCTGCATTGAGGAGACCGAGGGCTTTGGACAGGAGTAACCGAGGCCGCCCCTCCCACGCCCCCCAGCGCACATGTAGTCCTGAGTCCTCC
CTGCCTGAGAGGCCACTGGCCCCGCAGCCCTTGGGAGGCCCCCGTGGATGTGGCCCTGTGTGGGACCACACTGTCATCTCGCTGCTGGCA
GAAAAGCCTGATCCCAGGAGGCCCTGCAGTTCCCCCGACCCGCGGATGGCAGTCTGGAATAAAGCCCCCTAGTTGCCTTTGGCCCCACCT
TTGCAAAGTTCCAGAGGGCTGACCCTCTCTGCAAAACTCTCCCCTGTCCTCTAGACCCCACCCTGGGTGTATGTGAGTGTGCAAGGGAAG
GTGTTGCATCCCCAGGGGCTGCCGCAGAGGCCGGAGACCTCCTGGACTAGTTCGGCGAGGAGACTGGCCACTGGGGGTGGCTGTTCGGGA
CTGAGAGCGCCAAGGGTCTTTGCCAGCAAAGGAGGTTCTGCCTGTAATTGAGCCTCTCTGATGATGGAGATGAAGTGAAGGTCTGAGGGA
GCGGGCCCTGGGGCGAGGCCATCTCTGCCTGCCTCCCTAGCAGGCGCCAGCGGTGGAGGCTGAGTCGCAGGACACATGCCGGCCAGTTAA
TTCATTCTCAGCCAATGAAGGTTTGTCTAAGCTGCCTGGGTATCCACGGGACAAAAACAGCAAACTCCCTCAGACTTTGTCCATGTATAA
ACTTGAAGTGGTTGTGTTGTAGGGTTGCAGGTTTTTTGTTACGCTGCTGTCACTTTCTGTCCAGGAGCTGGCACCCCAGGTGTTCTGAGA
CCTTGAGGGACCCAGACCTTTGGGTCCAAGAGTTTCCCAAACAGCCACGCCTCTCAGGAACCCACCTGGCGGTTCCGTGAGCTCAGGCAG
GCCTGACCCGGCGGCACAGCCTGGCAGGGACCTCGTCCCCAAGCCTGGCAGAATGAGAGGGGTTGAGGTCCCGAGCGCCACTCCTAGCCT
TGCCGCCTTCAATAGAGAAGAAATCCCTTTGCTAGATAGGGTCCCCCAGGCAGTCCCCAGTGGCGGGACACAGGGGTCCGGCTGTGGAGC
TCCCCTGCCAGCCCCTGGAGCTCCAGGAGGGCCTGTTGGTCCCCTGTTCAGAATGGAGTGCAGCCCGCCAGCGGAAAGTGTTCATTCTGC
ATAGGTGTGAGGCTTTATCTGCACACAGGACATGAAAACCAGCAGAAAGGCCCTGAGCTGCTGCATAGCCCCATCTGATTTCTGCAGTTC
CCGCCAGCCTCCAACACGGGGACTCTGCCGTAACTGGAATCTTCATAGGTCATATTGAAATCTTCAAGGTGACCATGCCCCACCGGGGTG
CTGGGGCAGTAGTCATGGCAGACTCCCGGCCTGGGCCCCCAGGATTCTAGGACCCCCAGGCAGCCCCTTGGACTGGTCCCGGGTGCCTTC
CAAGCACAGTCTCCATGCTCCCAGATTCTCGACCTTCCCCCGGCCCGGGAGGTGCAGCCTGCGTCTGCCTCTGTCGTGTGTGCTGATTTG
AGTGGCTTAGCTTGCCACAGCGCAGCCTCTTCTGTCCCTTTCAGTCATTTGCTGTACTTCCCTGTGGCACGTTACCATGGAAGCCGCTCC
AGGGTGGGTCAGGGTGCAAGCTGCTGGTGAGGTTTGGAAGCATCAGGCTCACGGGTGTTCATGTGTGTTCGTGCGTGTGTGTGCGTACGT
GTATATAACTGAAGTGTCTGTACGGAATGCCCTTTGCTAGCCATGGGCTGGTCACCAGATTGTTTTGTAATGCCCGCCCCTTGCCTCGAT
ATTGCCAGTTTCTTGTGCAATAAACAATCAGCAGCTGTGGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAG
TGGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGG
GTAGAAATGCATTTTATTCTTTAAGTTCACGTAAGATACAAGTTTCAGACAGGGTCTGAAGGACTGGATTGGCCAAACATCAGACCTGTC
TTCCAAGGAGACCAAGTCCTGGCTACATCCCAGCCTGTGGTTACAGTGCAGACAGGCCATGTGAGCCACCGCTGCCAGCACAGAGCGTCC
TTCCCCCTGTAGACTAGTGCCGTAGGGAGTACCTGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCATCTCCAGGGAGCAAGA
CAGAGACGCAGGAATGGAAAGCGGAGTTCCTAACAGGATGAAAGTTCCCCCATCAGTTCCCCCAGTACCTCCAAGCAAGTAGCTTTCCAC
ATTTGTCACAGAAATCAGAGGAGAGACGGTGTTGGGAGCCCTTTGGAGAACGCCAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAA
TGTCACAACCTCTCTGATCTTGTGCTCAGCATGATTCTTTAATAGAAGTTTTATTTTTTCGTGCACTCTGCTAATCATGTGGGTGAGCCA
GTGGAACAGCGGGAGACCTGTGCTAGTTTTACAGATTGCCTCCTTATGACGCGGCTCAAAAGGAAACCAAGTGGTCAGGAGTTGTTTCTG
ACCCACTGATCTCTACTACCACAAGGAAAATAGTTTAGGAGAAACCAGCTTTTACTGTTTTTGAAAAATTACAGCTTCACCCTGTCAAGT
TAACAAGGAATGCCTGTGCCAATAAAAGTTTTCTCCAACTTGAAGTCTACTCTGATGGGATCTCAGATCCTTTGTCACTGCCTATAGACT
TGTAGCTGCTGTCTCTCTTTGTCCCTGCAGAGAATCACGTCCTGGAACTGCATGTTCTTGCGACTCTTGGGACTTCATCTTAACTTCTCG
CTGCCCCAGCCATGTTTTCAACCATGGCATCCCTCCCCCAATTAGTTCCCTGTCATCCTCGTCAACCTTCTCTGTAAGTGCCTGGTAAGC
TTGCCCTTGCTTAAGAACTCAAAACATAGCTGTGCTCTATTTTTTTGTTGTTGTTGTGACTGACAGAGTGAGATTCCGTCTCCCAGGCTG
GAGTGCAGTGGCGCCTTCTCAGCTCACTGCAACCTGCAGCCTCCTAGATTCAAGCGATTCTCCTGCTTCAGCCTTCCGAGTAGCTGGGAT
GACAGGCACTCACCAATATGCCTGGGTAATTTTTGTATTTTTAAGTACATACAGGATTTCACCATGTTGGCCAGGCTAGTTTCAAACTCC
CGGCCTCAGGTGGTCTGCCTGCCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACTGGGCCCTGCCTGTATTTTTTATCAGCC
ACAAATCCAGCAACAAGCTGAGGATTCAGCTCATAAAACAGGCTTGGTGTCTTGGTGATCTCACATAACCAAGATGCTACCCCGTGGGGA
ACCACATCCCCCTGGATGCCCTCCAGCCTTGGTTTGGGCTGGAGTCAGGGCCTGTATACAGTATTTTGAATTTGTATGCCACTGGTTTGC
ATTGCTGGTCAGGAACTCTAGTGCTTTGCATAGCCCTGGTTTAGAAACATGTTATAGCAGTTCTTGGTATAGAGCAAACTAGAAGAACCA
GCAATCATTCCACTGTCCTGCCAAGGTACACCTCAGTACTCCCCTTCCCAACTGAAGTGGTATGAGGCTAGCTCTTTCCAAAAGCATTCA
AGTTTGGCTTCTGATGTGACTCAGAATTTAGGAACCAGATGCTAGATCAAATAAGCTCTGAAAATCTGAGGAACATTGTAGGAAAGGTTT
GTTAAGCATCTCTTAAGTGCCATGATGAGCATAACAGCCGGCCGTCGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGG
GAGGATGACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGCTGAAACCTCACCTCTACTAAAAATACAAAAATTAGCTGGGCATGG
TGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGACA
GTGCCAGTGCACTCCAGCCTCGGTGACAGCGCAAGGCTCCGTCTCAATAATTAAAAAAAAAAAAAAAAAAAAAAAGGCCGGGCGCAGTGG
CTCAAGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGAGGTCAGGAGTTTTGAGATCAGCCTTGGCAACACGGTG
AAACCCCATCTCTACTAAAAATACAAAATTAGCCAAGCATGCTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGTACGAGAA
TCGCTTGAACCTGGGAGGCAGAGGATGCAGTGAGCCGAGATCACGCCATTGCACTCCAGCCTGGGGGACAAGAGTGAATCTGTGTCTCAC
CAAAAAAAAAAAGAAAAAGAAAGATGCTTAACAAAGGTTACCATAAGCCACAAATTCATAACCACTTATCCTTCCAGTTTCAAGTAGAAT
ATATTCATAACCTCAATAAAGTTCTCCCTGCTCCCAAAGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATCCGCAT
CCTGGGCTGGGGAGTGGAGAATGGCACACCCTACTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACAATGGATACAATTCCTA
CAGCGTCTCCAATAGCGAGAAGGACATCATGGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACTTCCT

>99524_99524_1_WWP2-CTSB_WWP2_chr16_69973809_ENST00000359154_CTSB_chr8_11705230_ENST00000353047_length(amino acids)=858AA_BP=
MWPRQLHGDDMASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSH
LDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSG
TAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAP
LSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVD
HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGM
IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQ
QIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGK
FIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD
WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTG

--------------------------------------------------------------
>99524_99524_2_WWP2-CTSB_WWP2_chr16_69973809_ENST00000359154_CTSB_chr8_11705230_ENST00000434271_length(transcript)=7437nt_BP=4449nt
GCGCGGTCACGTGACCCGGCCCGAGTGCGGGCGGTGGAAGGCGGAAGTAGGAGAGGAGTTCGGCGCCGCTTCTGTGGCCACGGCAGCTTC
ACGGTGATGATATGGCATCTGCCAGCTCTAGCCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTTTGAAAGTGGTGTCCG
CAAAGCCCAAGGTGCATAATCGTCAACCTCGAATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTGAGACCAAGAAGACTG
GGAAGCGCATTGGGAGCTCTGAGCTTCTCTGGAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAGATTTAAAGGTCTGGA
GCTGCCATACCTTGAGAAATGAACTGCTAGGCACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGGGCAAAATGGAGAACA
TGCAGCTGACCCTGAACCTGCAGACGGAGAACAAAGGCAGCGTTGTCTCAGGCGGAGAGCTGACAATTTTCCTGGACGGGCCAACTGTTG
ATCTGGGAAATGTGCCTAATGGCAGTGCCCTGACAGATGGATCACAGCTGCCTTCGAGAGACTCCAGTGGAACAGCAGTAGCTCCAGAGA
ACCGGCACCAGCCCCCCAGCACAAACTGCTTTGGTGGAAGATCCCGGACGCACAGACATTCGGGTGCTTCAGCCAGAACAACCCCAGCAA
CCGGCGAGCAAAGCCCCGGTGCTCGGAGCCGGCACCGCCAGCCCGTCAAGAACTCAGGCCACAGTGGCTTGGCCAATGGCACAGTGAATG
ATGAACCCACAACAGCCACTGATCCCGAAGAACCTTCCGTTGTTGGTGTGACGTCCCCACCTGCTGCACCCTTGAGTGTGACCCCGAATC
CCAACACGACTTCTCTCCCTGCCCCAGCCACACCGGCTGAAGGAGAGGAACCCAGCACTTCGGGTACACAGCAGCTCCCAGCGGCTGCCC
AGGCCCCCGACGCTCTGCCTGCTGGATGGGAACAGCGAGAGCTGCCCAACGGACGTGTCTATTATGTTGACCACAATACCAAGACCACCA
CCTGGGAGCGGCCCCTTCCTCCAGGCTGGGAAAAACGCACAGATCCCCGAGGCAGGTTTTACTATGTGGATCACAATACTCGGACCACCA
CCTGGCAGCGTCCGACCGCGGAGTACGTGCGCAACTATGAGCAGTGGCAGTCGCAGCGGAATCAGCTCCAGGGGGCCATGCAGCACTTCA
GCCAAAGATTCCTCTACCAGTCTTCGAGTGCTTCGACTGACCATGATCCCCTGGGCCCCCTCCCTCCTGGCTGGGAGAAGAGACAGGACA
ATGGACGGGTGTATTACGTGAACCATAACACTCGCACGACCCAGTGGGAGGATCCCCGGACCCAGGGGATGATCCAGGAACCAGCTCTGC
CCCCAGGATGGGAGATGAAATACACCAGCGAGGGGGTGCGATACTTTGTGGACCACAATACCCGCACCACCACCTTTAAGGATCCTCGCC
CGGGGTTTGAGTCGGGGACGAAGCAAGGTTCCCCTGGTGCTTATGACCGCAGTTTTCGGTGGAAGTATCACCAGTTCCGTTTCCTCTGCC
ATTCAAATGCCCTACCTAGCCACGTGAAGATCAGCGTTTCCAGGCAGACGCTTTTCGAAGATTCCTTCCAACAGATCATGAACATGAAAC
CCTATGACCTGCGCCGCCGGCTCTACATCATCATGCGTGGCGAGGAGGGCCTGGACTATGGGGGCATCGCCAGAGAGTGGTTTTTCCTCC
TGTCTCATGAGGTGCTCAACCCTATGTATTGTTTATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCA
TCAACCCGGACCACCTCACCTACTTTCGCTTTATAGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCA
CCCTCCCTTTCTACAAGCGGATGCTCAATAAGAGACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCT
GGATCAAAGAGAACAACCTGGAAGAATGTGGCCTGGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGC
TGAAGGAGGGCGGCGAGAGCATCCGGGTCACAGAGGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCG
TGGAAGAGCAGACCAAAGCCTTCCTGGATGGCTTCAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGC
TGATGCTGTGCGGCATGCAGGAGATAGACATGAGCGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCC
AGTGGTTCTGGCAGGTGGTGAAGGAGATGGACAACGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCG
GGGGATTTGCCGAACTCATCGGTAGCAACGGACCACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACA
CCTGCATTGAGGAGACCGAGGGCTTTGGACAGGAGTAACCGAGGCCGCCCCTCCCACGCCCCCCAGCGCACATGTAGTCCTGAGTCCTCC
CTGCCTGAGAGGCCACTGGCCCCGCAGCCCTTGGGAGGCCCCCGTGGATGTGGCCCTGTGTGGGACCACACTGTCATCTCGCTGCTGGCA
GAAAAGCCTGATCCCAGGAGGCCCTGCAGTTCCCCCGACCCGCGGATGGCAGTCTGGAATAAAGCCCCCTAGTTGCCTTTGGCCCCACCT
TTGCAAAGTTCCAGAGGGCTGACCCTCTCTGCAAAACTCTCCCCTGTCCTCTAGACCCCACCCTGGGTGTATGTGAGTGTGCAAGGGAAG
GTGTTGCATCCCCAGGGGCTGCCGCAGAGGCCGGAGACCTCCTGGACTAGTTCGGCGAGGAGACTGGCCACTGGGGGTGGCTGTTCGGGA
CTGAGAGCGCCAAGGGTCTTTGCCAGCAAAGGAGGTTCTGCCTGTAATTGAGCCTCTCTGATGATGGAGATGAAGTGAAGGTCTGAGGGA
GCGGGCCCTGGGGCGAGGCCATCTCTGCCTGCCTCCCTAGCAGGCGCCAGCGGTGGAGGCTGAGTCGCAGGACACATGCCGGCCAGTTAA
TTCATTCTCAGCCAATGAAGGTTTGTCTAAGCTGCCTGGGTATCCACGGGACAAAAACAGCAAACTCCCTCAGACTTTGTCCATGTATAA
ACTTGAAGTGGTTGTGTTGTAGGGTTGCAGGTTTTTTGTTACGCTGCTGTCACTTTCTGTCCAGGAGCTGGCACCCCAGGTGTTCTGAGA
CCTTGAGGGACCCAGACCTTTGGGTCCAAGAGTTTCCCAAACAGCCACGCCTCTCAGGAACCCACCTGGCGGTTCCGTGAGCTCAGGCAG
GCCTGACCCGGCGGCACAGCCTGGCAGGGACCTCGTCCCCAAGCCTGGCAGAATGAGAGGGGTTGAGGTCCCGAGCGCCACTCCTAGCCT
TGCCGCCTTCAATAGAGAAGAAATCCCTTTGCTAGATAGGGTCCCCCAGGCAGTCCCCAGTGGCGGGACACAGGGGTCCGGCTGTGGAGC
TCCCCTGCCAGCCCCTGGAGCTCCAGGAGGGCCTGTTGGTCCCCTGTTCAGAATGGAGTGCAGCCCGCCAGCGGAAAGTGTTCATTCTGC
ATAGGTGTGAGGCTTTATCTGCACACAGGACATGAAAACCAGCAGAAAGGCCCTGAGCTGCTGCATAGCCCCATCTGATTTCTGCAGTTC
CCGCCAGCCTCCAACACGGGGACTCTGCCGTAACTGGAATCTTCATAGGTCATATTGAAATCTTCAAGGTGACCATGCCCCACCGGGGTG
CTGGGGCAGTAGTCATGGCAGACTCCCGGCCTGGGCCCCCAGGATTCTAGGACCCCCAGGCAGCCCCTTGGACTGGTCCCGGGTGCCTTC
CAAGCACAGTCTCCATGCTCCCAGATTCTCGACCTTCCCCCGGCCCGGGAGGTGCAGCCTGCGTCTGCCTCTGTCGTGTGTGCTGATTTG
AGTGGCTTAGCTTGCCACAGCGCAGCCTCTTCTGTCCCTTTCAGTCATTTGCTGTACTTCCCTGTGGCACGTTACCATGGAAGCCGCTCC
AGGGTGGGTCAGGGTGCAAGCTGCTGGTGAGGTTTGGAAGCATCAGGCTCACGGGTGTTCATGTGTGTTCGTGCGTGTGTGTGCGTACGT
GTATATAACTGAAGTGTCTGTACGGAATGCCCTTTGCTAGCCATGGGCTGGTCACCAGATTGTTTTGTAATGCCCGCCCCTTGCCTCGAT
ATTGCCAGTTTCTTGTGCAATAAACAATCAGCAGCTGTGGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAG
TGGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGG
GTAGAAATGCATTTTATTCTTTAAGTTCACGTAAGATACAAGTTTCAGACAGGGTCTGAAGGACTGGATTGGCCAAACATCAGACCTGTC
TTCCAAGGAGACCAAGTCCTGGCTACATCCCAGCCTGTGGTTACAGTGCAGACAGGCCATGTGAGCCACCGCTGCCAGCACAGAGCGTCC
TTCCCCCTGTAGACTAGTGCCGTAGGGAGTACCTGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCATCTCCAGGGAGCAAGA
CAGAGACGCAGGAATGGAAAGCGGAGTTCCTAACAGGATGAAAGTTCCCCCATCAGTTCCCCCAGTACCTCCAAGCAAGTAGCTTTCCAC
ATTTGTCACAGAAATCAGAGGAGAGACGGTGTTGGGAGCCCTTTGGAGAACGCCAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAA
TGTCACAACCTCTCTGATCTTGTGCTCAGCATGATTCTTTAATAGAAGTTTTATTTTTTCGTGCACTCTGCTAATCATGTGGGTGAGCCA
GTGGAACAGCGGGAGACCTGTGCTAGTTTTACAGATTGCCTCCTTATGACGCGGCTCAAAAGGAAACCAAGTGGTCAGGAGTTGTTTCTG
ACCCACTGATCTCTACTACCACAAGGAAAATAGTTTAGGAGAAACCAGCTTTTACTGTTTTTGAAAAATTACAGCTTCACCCTGTCAAGT
TAACAAGGAATGCCTGTGCCAATAAAAGTTTTCTCCAACTTGAAGTCTACTCTGATGGGATCTCAGATCCTTTGTCACTGCCTATAGACT
TGTAGCTGCTGTCTCTCTTTGTCCCTGCAGAGAATCACGTCCTGGAACTGCATGTTCTTGCGACTCTTGGGACTTCATCTTAACTTCTCG
CTGCCCCAGCCATGTTTTCAACCATGGCATCCCTCCCCCAATTAGTTCCCTGTCATCCTCGTCAACCTTCTCTGTAAGTGCCTGGTAAGC
TTGCCCTTGCTTAAGAACTCAAAACATAGCTGTGCTCTATTTTTTTGTTGTTGTTGTGACTGACAGAGTGAGATTCCGTCTCCCAGGCTG
GAGTGCAGTGGCGCCTTCTCAGCTCACTGCAACCTGCAGCCTCCTAGATTCAAGCGATTCTCCTGCTTCAGCCTTCCGAGTAGCTGGGAT
GACAGGCACTCACCAATATGCCTGGGTAATTTTTGTATTTTTAAGTACATACAGGATTTCACCATGTTGGCCAGGCTAGTTTCAAACTCC
CGGCCTCAGGTGGTCTGCCTGCCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACTGGGCCCTGCCTGTATTTTTTATCAGCC
ACAAATCCAGCAACAAGCTGAGGATTCAGCTCATAAAACAGGCTTGGTGTCTTGGTGATCTCACATAACCAAGATGCTACCCCGTGGGGA
ACCACATCCCCCTGGATGCCCTCCAGCCTTGGTTTGGGCTGGAGTCAGGGCCTGTATACAGTATTTTGAATTTGTATGCCACTGGTTTGC
ATTGCTGGTCAGGAACTCTAGTGCTTTGCATAGCCCTGGTTTAGAAACATGTTATAGCAGTTCTTGGTATAGAGCAAACTAGAAGAACCA
GCAATCATTCCACTGTCCTGCCAAGGTACACCTCAGTACTCCCCTTCCCAACTGAAGTGGTATGAGGCTAGCTCTTTCCAAAAGCATTCA
AGTTTGGCTTCTGATGTGACTCAGAATTTAGGAACCAGATGCTAGATCAAATAAGCTCTGAAAATCTGAGGAACATTGTAGGAAAGGTTT
GTTAAGCATCTCTTAAGTGCCATGATGAGCATAACAGCCGGCCGTCGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGG
GAGGATGACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGCTGAAACCTCACCTCTACTAAAAATACAAAAATTAGCTGGGCATGG
TGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGACA
GTGCCAGTGCACTCCAGCCTCGGTGACAGCGCAAGGCTCCGTCTCAATAATTAAAAAAAAAAAAAAAAAAAAAAAGGCCGGGCGCAGTGG
CTCAAGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGAGGTCAGGAGTTTTGAGATCAGCCTTGGCAACACGGTG
AAACCCCATCTCTACTAAAAATACAAAATTAGCCAAGCATGCTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGTACGAGAA
TCGCTTGAACCTGGGAGGCAGAGGATGCAGTGAGCCGAGATCACGCCATTGCACTCCAGCCTGGGGGACAAGAGTGAATCTGTGTCTCAC
CAAAAAAAAAAAGAAAAAGAAAGATGCTTAACAAAGGTTACCATAAGCCACAAATTCATAACCACTTATCCTTCCAGTTTCAAGTAGAAT
ATATTCATAACCTCAATAAAGTTCTCCCTGCTCCCAAAGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATCCGCAT
CCTGGGCTGGGGAGTGGAGAATGGCACACCCTACTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACAATGGATACAATTCCTA
CAGCGTCTCCAATAGCGAGAAGGACATCATGGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACTTCCT

>99524_99524_2_WWP2-CTSB_WWP2_chr16_69973809_ENST00000359154_CTSB_chr8_11705230_ENST00000434271_length(amino acids)=858AA_BP=
MWPRQLHGDDMASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSH
LDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSG
TAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAP
LSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVD
HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGM
IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQ
QIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGK
FIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD
WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTG

--------------------------------------------------------------
>99524_99524_3_WWP2-CTSB_WWP2_chr16_69973809_ENST00000359154_CTSB_chr8_11705230_ENST00000453527_length(transcript)=5641nt_BP=4449nt
GCGCGGTCACGTGACCCGGCCCGAGTGCGGGCGGTGGAAGGCGGAAGTAGGAGAGGAGTTCGGCGCCGCTTCTGTGGCCACGGCAGCTTC
ACGGTGATGATATGGCATCTGCCAGCTCTAGCCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTTTGAAAGTGGTGTCCG
CAAAGCCCAAGGTGCATAATCGTCAACCTCGAATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTGAGACCAAGAAGACTG
GGAAGCGCATTGGGAGCTCTGAGCTTCTCTGGAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAGATTTAAAGGTCTGGA
GCTGCCATACCTTGAGAAATGAACTGCTAGGCACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGGGCAAAATGGAGAACA
TGCAGCTGACCCTGAACCTGCAGACGGAGAACAAAGGCAGCGTTGTCTCAGGCGGAGAGCTGACAATTTTCCTGGACGGGCCAACTGTTG
ATCTGGGAAATGTGCCTAATGGCAGTGCCCTGACAGATGGATCACAGCTGCCTTCGAGAGACTCCAGTGGAACAGCAGTAGCTCCAGAGA
ACCGGCACCAGCCCCCCAGCACAAACTGCTTTGGTGGAAGATCCCGGACGCACAGACATTCGGGTGCTTCAGCCAGAACAACCCCAGCAA
CCGGCGAGCAAAGCCCCGGTGCTCGGAGCCGGCACCGCCAGCCCGTCAAGAACTCAGGCCACAGTGGCTTGGCCAATGGCACAGTGAATG
ATGAACCCACAACAGCCACTGATCCCGAAGAACCTTCCGTTGTTGGTGTGACGTCCCCACCTGCTGCACCCTTGAGTGTGACCCCGAATC
CCAACACGACTTCTCTCCCTGCCCCAGCCACACCGGCTGAAGGAGAGGAACCCAGCACTTCGGGTACACAGCAGCTCCCAGCGGCTGCCC
AGGCCCCCGACGCTCTGCCTGCTGGATGGGAACAGCGAGAGCTGCCCAACGGACGTGTCTATTATGTTGACCACAATACCAAGACCACCA
CCTGGGAGCGGCCCCTTCCTCCAGGCTGGGAAAAACGCACAGATCCCCGAGGCAGGTTTTACTATGTGGATCACAATACTCGGACCACCA
CCTGGCAGCGTCCGACCGCGGAGTACGTGCGCAACTATGAGCAGTGGCAGTCGCAGCGGAATCAGCTCCAGGGGGCCATGCAGCACTTCA
GCCAAAGATTCCTCTACCAGTCTTCGAGTGCTTCGACTGACCATGATCCCCTGGGCCCCCTCCCTCCTGGCTGGGAGAAGAGACAGGACA
ATGGACGGGTGTATTACGTGAACCATAACACTCGCACGACCCAGTGGGAGGATCCCCGGACCCAGGGGATGATCCAGGAACCAGCTCTGC
CCCCAGGATGGGAGATGAAATACACCAGCGAGGGGGTGCGATACTTTGTGGACCACAATACCCGCACCACCACCTTTAAGGATCCTCGCC
CGGGGTTTGAGTCGGGGACGAAGCAAGGTTCCCCTGGTGCTTATGACCGCAGTTTTCGGTGGAAGTATCACCAGTTCCGTTTCCTCTGCC
ATTCAAATGCCCTACCTAGCCACGTGAAGATCAGCGTTTCCAGGCAGACGCTTTTCGAAGATTCCTTCCAACAGATCATGAACATGAAAC
CCTATGACCTGCGCCGCCGGCTCTACATCATCATGCGTGGCGAGGAGGGCCTGGACTATGGGGGCATCGCCAGAGAGTGGTTTTTCCTCC
TGTCTCATGAGGTGCTCAACCCTATGTATTGTTTATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCA
TCAACCCGGACCACCTCACCTACTTTCGCTTTATAGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCA
CCCTCCCTTTCTACAAGCGGATGCTCAATAAGAGACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCT
GGATCAAAGAGAACAACCTGGAAGAATGTGGCCTGGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGC
TGAAGGAGGGCGGCGAGAGCATCCGGGTCACAGAGGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCG
TGGAAGAGCAGACCAAAGCCTTCCTGGATGGCTTCAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGC
TGATGCTGTGCGGCATGCAGGAGATAGACATGAGCGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCC
AGTGGTTCTGGCAGGTGGTGAAGGAGATGGACAACGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCG
GGGGATTTGCCGAACTCATCGGTAGCAACGGACCACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACA
CCTGCATTGAGGAGACCGAGGGCTTTGGACAGGAGTAACCGAGGCCGCCCCTCCCACGCCCCCCAGCGCACATGTAGTCCTGAGTCCTCC
CTGCCTGAGAGGCCACTGGCCCCGCAGCCCTTGGGAGGCCCCCGTGGATGTGGCCCTGTGTGGGACCACACTGTCATCTCGCTGCTGGCA
GAAAAGCCTGATCCCAGGAGGCCCTGCAGTTCCCCCGACCCGCGGATGGCAGTCTGGAATAAAGCCCCCTAGTTGCCTTTGGCCCCACCT
TTGCAAAGTTCCAGAGGGCTGACCCTCTCTGCAAAACTCTCCCCTGTCCTCTAGACCCCACCCTGGGTGTATGTGAGTGTGCAAGGGAAG
GTGTTGCATCCCCAGGGGCTGCCGCAGAGGCCGGAGACCTCCTGGACTAGTTCGGCGAGGAGACTGGCCACTGGGGGTGGCTGTTCGGGA
CTGAGAGCGCCAAGGGTCTTTGCCAGCAAAGGAGGTTCTGCCTGTAATTGAGCCTCTCTGATGATGGAGATGAAGTGAAGGTCTGAGGGA
GCGGGCCCTGGGGCGAGGCCATCTCTGCCTGCCTCCCTAGCAGGCGCCAGCGGTGGAGGCTGAGTCGCAGGACACATGCCGGCCAGTTAA
TTCATTCTCAGCCAATGAAGGTTTGTCTAAGCTGCCTGGGTATCCACGGGACAAAAACAGCAAACTCCCTCAGACTTTGTCCATGTATAA
ACTTGAAGTGGTTGTGTTGTAGGGTTGCAGGTTTTTTGTTACGCTGCTGTCACTTTCTGTCCAGGAGCTGGCACCCCAGGTGTTCTGAGA
CCTTGAGGGACCCAGACCTTTGGGTCCAAGAGTTTCCCAAACAGCCACGCCTCTCAGGAACCCACCTGGCGGTTCCGTGAGCTCAGGCAG
GCCTGACCCGGCGGCACAGCCTGGCAGGGACCTCGTCCCCAAGCCTGGCAGAATGAGAGGGGTTGAGGTCCCGAGCGCCACTCCTAGCCT
TGCCGCCTTCAATAGAGAAGAAATCCCTTTGCTAGATAGGGTCCCCCAGGCAGTCCCCAGTGGCGGGACACAGGGGTCCGGCTGTGGAGC
TCCCCTGCCAGCCCCTGGAGCTCCAGGAGGGCCTGTTGGTCCCCTGTTCAGAATGGAGTGCAGCCCGCCAGCGGAAAGTGTTCATTCTGC
ATAGGTGTGAGGCTTTATCTGCACACAGGACATGAAAACCAGCAGAAAGGCCCTGAGCTGCTGCATAGCCCCATCTGATTTCTGCAGTTC
CCGCCAGCCTCCAACACGGGGACTCTGCCGTAACTGGAATCTTCATAGGTCATATTGAAATCTTCAAGGTGACCATGCCCCACCGGGGTG
CTGGGGCAGTAGTCATGGCAGACTCCCGGCCTGGGCCCCCAGGATTCTAGGACCCCCAGGCAGCCCCTTGGACTGGTCCCGGGTGCCTTC
CAAGCACAGTCTCCATGCTCCCAGATTCTCGACCTTCCCCCGGCCCGGGAGGTGCAGCCTGCGTCTGCCTCTGTCGTGTGTGCTGATTTG
AGTGGCTTAGCTTGCCACAGCGCAGCCTCTTCTGTCCCTTTCAGTCATTTGCTGTACTTCCCTGTGGCACGTTACCATGGAAGCCGCTCC
AGGGTGGGTCAGGGTGCAAGCTGCTGGTGAGGTTTGGAAGCATCAGGCTCACGGGTGTTCATGTGTGTTCGTGCGTGTGTGTGCGTACGT
GTATATAACTGAAGTGTCTGTACGGAATGCCCTTTGCTAGCCATGGGCTGGTCACCAGATTGTTTTGTAATGCCCGCCCCTTGCCTCGAT
ATTGCCAGTTTCTTGTGCAATAAACAATCAGCAGCTGTGGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAG
TGGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGG
GTAGAAATGCATTTTATTCTTTAAGTTCACGTAAGATACAAGTTTCAGACAGGGTCTGAAGGACTGGATTGGCCAAACATCAGACCTGTC
TTCCAAGGAGACCAAGTCCTGGCTACATCCCAGCCTGTGGTTACAGTGCAGACAGGCCATGTGAGCCACCGCTGCCAGCACAGAGCGTCC
TTCCCCCTGTAGACTAGTGCCGTAGGGAGTACCTGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCATCTCCAGGGAGCAAGA
CAGAGACGCAGGAATGGAAAGCGGAGTTCCTAACAGGATGAAAGTTCCCCCATCAGTTCCCCCAGTACCTCCAAGCAAGTAGCTTTCCAC
ATTTGTCACAGAAATCAGAGGAGAGACGGTGTTGGGAGCCCTTTGGAGAACGCCAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAA
TGTCACAACCTCTCTGATCTTGTGCTCAGCATGATTCTTTAATAGAAGTTTTATTTTTTCGTGCACTCTGCTAATCATGTGGGTGAGCCA
GTGGAACAGCGGGAGACCTGTGCTAGTTTTACAGATTGCCTCCTTATGACGCGGCTCAAAAGGAAACCAAGTGGTCAGGAGTTGTTTCTG
ACCCACTGATCTCTACTACCACAAGGAAAATAGTTTAGGAGAAACCAGCTTTTACTGTTTTTGAAAAATTACAGCTTCACCCTGTCAAGT
TAACAAGGAATGCCTGTGCCAATAAAAGTTTTCTCCAACTTGGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATCC
GCATCCTGGGCTGGGGAGTGGAGAATGGCACACCCTACTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACAATGGATACAATT
CCTACAGCGTCTCCAATAGCGAGAAGGACATCATGGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACT

>99524_99524_3_WWP2-CTSB_WWP2_chr16_69973809_ENST00000359154_CTSB_chr8_11705230_ENST00000453527_length(amino acids)=858AA_BP=
MWPRQLHGDDMASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSH
LDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSG
TAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAP
LSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVD
HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGM
IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQ
QIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGK
FIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD
WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTG

--------------------------------------------------------------
>99524_99524_4_WWP2-CTSB_WWP2_chr16_69973809_ENST00000359154_CTSB_chr8_11705230_ENST00000530640_length(transcript)=5068nt_BP=4449nt
GCGCGGTCACGTGACCCGGCCCGAGTGCGGGCGGTGGAAGGCGGAAGTAGGAGAGGAGTTCGGCGCCGCTTCTGTGGCCACGGCAGCTTC
ACGGTGATGATATGGCATCTGCCAGCTCTAGCCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTTTGAAAGTGGTGTCCG
CAAAGCCCAAGGTGCATAATCGTCAACCTCGAATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTGAGACCAAGAAGACTG
GGAAGCGCATTGGGAGCTCTGAGCTTCTCTGGAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAGATTTAAAGGTCTGGA
GCTGCCATACCTTGAGAAATGAACTGCTAGGCACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGGGCAAAATGGAGAACA
TGCAGCTGACCCTGAACCTGCAGACGGAGAACAAAGGCAGCGTTGTCTCAGGCGGAGAGCTGACAATTTTCCTGGACGGGCCAACTGTTG
ATCTGGGAAATGTGCCTAATGGCAGTGCCCTGACAGATGGATCACAGCTGCCTTCGAGAGACTCCAGTGGAACAGCAGTAGCTCCAGAGA
ACCGGCACCAGCCCCCCAGCACAAACTGCTTTGGTGGAAGATCCCGGACGCACAGACATTCGGGTGCTTCAGCCAGAACAACCCCAGCAA
CCGGCGAGCAAAGCCCCGGTGCTCGGAGCCGGCACCGCCAGCCCGTCAAGAACTCAGGCCACAGTGGCTTGGCCAATGGCACAGTGAATG
ATGAACCCACAACAGCCACTGATCCCGAAGAACCTTCCGTTGTTGGTGTGACGTCCCCACCTGCTGCACCCTTGAGTGTGACCCCGAATC
CCAACACGACTTCTCTCCCTGCCCCAGCCACACCGGCTGAAGGAGAGGAACCCAGCACTTCGGGTACACAGCAGCTCCCAGCGGCTGCCC
AGGCCCCCGACGCTCTGCCTGCTGGATGGGAACAGCGAGAGCTGCCCAACGGACGTGTCTATTATGTTGACCACAATACCAAGACCACCA
CCTGGGAGCGGCCCCTTCCTCCAGGCTGGGAAAAACGCACAGATCCCCGAGGCAGGTTTTACTATGTGGATCACAATACTCGGACCACCA
CCTGGCAGCGTCCGACCGCGGAGTACGTGCGCAACTATGAGCAGTGGCAGTCGCAGCGGAATCAGCTCCAGGGGGCCATGCAGCACTTCA
GCCAAAGATTCCTCTACCAGTCTTCGAGTGCTTCGACTGACCATGATCCCCTGGGCCCCCTCCCTCCTGGCTGGGAGAAGAGACAGGACA
ATGGACGGGTGTATTACGTGAACCATAACACTCGCACGACCCAGTGGGAGGATCCCCGGACCCAGGGGATGATCCAGGAACCAGCTCTGC
CCCCAGGATGGGAGATGAAATACACCAGCGAGGGGGTGCGATACTTTGTGGACCACAATACCCGCACCACCACCTTTAAGGATCCTCGCC
CGGGGTTTGAGTCGGGGACGAAGCAAGGTTCCCCTGGTGCTTATGACCGCAGTTTTCGGTGGAAGTATCACCAGTTCCGTTTCCTCTGCC
ATTCAAATGCCCTACCTAGCCACGTGAAGATCAGCGTTTCCAGGCAGACGCTTTTCGAAGATTCCTTCCAACAGATCATGAACATGAAAC
CCTATGACCTGCGCCGCCGGCTCTACATCATCATGCGTGGCGAGGAGGGCCTGGACTATGGGGGCATCGCCAGAGAGTGGTTTTTCCTCC
TGTCTCATGAGGTGCTCAACCCTATGTATTGTTTATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCA
TCAACCCGGACCACCTCACCTACTTTCGCTTTATAGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCA
CCCTCCCTTTCTACAAGCGGATGCTCAATAAGAGACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCT
GGATCAAAGAGAACAACCTGGAAGAATGTGGCCTGGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGC
TGAAGGAGGGCGGCGAGAGCATCCGGGTCACAGAGGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCG
TGGAAGAGCAGACCAAAGCCTTCCTGGATGGCTTCAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGC
TGATGCTGTGCGGCATGCAGGAGATAGACATGAGCGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCC
AGTGGTTCTGGCAGGTGGTGAAGGAGATGGACAACGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCG
GGGGATTTGCCGAACTCATCGGTAGCAACGGACCACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACA
CCTGCATTGAGGAGACCGAGGGCTTTGGACAGGAGTAACCGAGGCCGCCCCTCCCACGCCCCCCAGCGCACATGTAGTCCTGAGTCCTCC
CTGCCTGAGAGGCCACTGGCCCCGCAGCCCTTGGGAGGCCCCCGTGGATGTGGCCCTGTGTGGGACCACACTGTCATCTCGCTGCTGGCA
GAAAAGCCTGATCCCAGGAGGCCCTGCAGTTCCCCCGACCCGCGGATGGCAGTCTGGAATAAAGCCCCCTAGTTGCCTTTGGCCCCACCT
TTGCAAAGTTCCAGAGGGCTGACCCTCTCTGCAAAACTCTCCCCTGTCCTCTAGACCCCACCCTGGGTGTATGTGAGTGTGCAAGGGAAG
GTGTTGCATCCCCAGGGGCTGCCGCAGAGGCCGGAGACCTCCTGGACTAGTTCGGCGAGGAGACTGGCCACTGGGGGTGGCTGTTCGGGA
CTGAGAGCGCCAAGGGTCTTTGCCAGCAAAGGAGGTTCTGCCTGTAATTGAGCCTCTCTGATGATGGAGATGAAGTGAAGGTCTGAGGGA
GCGGGCCCTGGGGCGAGGCCATCTCTGCCTGCCTCCCTAGCAGGCGCCAGCGGTGGAGGCTGAGTCGCAGGACACATGCCGGCCAGTTAA
TTCATTCTCAGCCAATGAAGGTTTGTCTAAGCTGCCTGGGTATCCACGGGACAAAAACAGCAAACTCCCTCAGACTTTGTCCATGTATAA
ACTTGAAGTGGTTGTGTTGTAGGGTTGCAGGTTTTTTGTTACGCTGCTGTCACTTTCTGTCCAGGAGCTGGCACCCCAGGTGTTCTGAGA
CCTTGAGGGACCCAGACCTTTGGGTCCAAGAGTTTCCCAAACAGCCACGCCTCTCAGGAACCCACCTGGCGGTTCCGTGAGCTCAGGCAG
GCCTGACCCGGCGGCACAGCCTGGCAGGGACCTCGTCCCCAAGCCTGGCAGAATGAGAGGGGTTGAGGTCCCGAGCGCCACTCCTAGCCT
TGCCGCCTTCAATAGAGAAGAAATCCCTTTGCTAGATAGGGTCCCCCAGGCAGTCCCCAGTGGCGGGACACAGGGGTCCGGCTGTGGAGC
TCCCCTGCCAGCCCCTGGAGCTCCAGGAGGGCCTGTTGGTCCCCTGTTCAGAATGGAGTGCAGCCCGCCAGCGGAAAGTGTTCATTCTGC
ATAGGTGTGAGGCTTTATCTGCACACAGGACATGAAAACCAGCAGAAAGGCCCTGAGCTGCTGCATAGCCCCATCTGATTTCTGCAGTTC
CCGCCAGCCTCCAACACGGGGACTCTGCCGTAACTGGAATCTTCATAGGTCATATTGAAATCTTCAAGGTGACCATGCCCCACCGGGGTG
CTGGGGCAGTAGTCATGGCAGACTCCCGGCCTGGGCCCCCAGGATTCTAGGACCCCCAGGCAGCCCCTTGGACTGGTCCCGGGTGCCTTC
CAAGCACAGTCTCCATGCTCCCAGATTCTCGACCTTCCCCCGGCCCGGGAGGTGCAGCCTGCGTCTGCCTCTGTCGTGTGTGCTGATTTG
AGTGGCTTAGCTTGCCACAGCGCAGCCTCTTCTGTCCCTTTCAGTCATTTGCTGTACTTCCCTGTGGCACGTTACCATGGAAGCCGCTCC
AGGGTGGGTCAGGGTGCAAGCTGCTGGTGAGGTTTGGAAGCATCAGGCTCACGGGTGTTCATGTGTGTTCGTGCGTGTGTGTGCGTACGT
GTATATAACTGAAGTGTCTGTACGGAATGCCCTTTGCTAGCCATGGGCTGGTCACCAGATTGTTTTGTAATGCCCGCCCCTTGCCTCGAT
ATTGCCAGTTTCTTGTGCAATAAACAATCAGCAGCTGTGAGAATCACGTCCTGGAACTGCATGTTCTTGCGACTCTTGGGACTTCATCTT
AACTTCTCGCTGCCCCAGCCATGTTTTCAACCATGGCATCCCTCCCCCAATTAGTTCCCTGTCATCCTCGTCAACCTTCTCTGTAAGTGC
CTGGTAAGCTTGCCCTTGCTTAAGAACTCAAAACATAGCTGTGCTCTAGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCG
AATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGC
GAGATCGGGGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAGAATGGCACAC
CCTACTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACAATGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCA
TGGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACTTCCTGCTCTACAAGTCAGGAGCCTGGCTACAGC

>99524_99524_4_WWP2-CTSB_WWP2_chr16_69973809_ENST00000359154_CTSB_chr8_11705230_ENST00000530640_length(amino acids)=858AA_BP=
MWPRQLHGDDMASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSH
LDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSG
TAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAP
LSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVD
HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGM
IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQ
QIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGK
FIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD
WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTG

--------------------------------------------------------------
>99524_99524_5_WWP2-CTSB_WWP2_chr16_69973809_ENST00000359154_CTSB_chr8_11705230_ENST00000531089_length(transcript)=5027nt_BP=4449nt
GCGCGGTCACGTGACCCGGCCCGAGTGCGGGCGGTGGAAGGCGGAAGTAGGAGAGGAGTTCGGCGCCGCTTCTGTGGCCACGGCAGCTTC
ACGGTGATGATATGGCATCTGCCAGCTCTAGCCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTTTGAAAGTGGTGTCCG
CAAAGCCCAAGGTGCATAATCGTCAACCTCGAATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTGAGACCAAGAAGACTG
GGAAGCGCATTGGGAGCTCTGAGCTTCTCTGGAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAGATTTAAAGGTCTGGA
GCTGCCATACCTTGAGAAATGAACTGCTAGGCACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGGGCAAAATGGAGAACA
TGCAGCTGACCCTGAACCTGCAGACGGAGAACAAAGGCAGCGTTGTCTCAGGCGGAGAGCTGACAATTTTCCTGGACGGGCCAACTGTTG
ATCTGGGAAATGTGCCTAATGGCAGTGCCCTGACAGATGGATCACAGCTGCCTTCGAGAGACTCCAGTGGAACAGCAGTAGCTCCAGAGA
ACCGGCACCAGCCCCCCAGCACAAACTGCTTTGGTGGAAGATCCCGGACGCACAGACATTCGGGTGCTTCAGCCAGAACAACCCCAGCAA
CCGGCGAGCAAAGCCCCGGTGCTCGGAGCCGGCACCGCCAGCCCGTCAAGAACTCAGGCCACAGTGGCTTGGCCAATGGCACAGTGAATG
ATGAACCCACAACAGCCACTGATCCCGAAGAACCTTCCGTTGTTGGTGTGACGTCCCCACCTGCTGCACCCTTGAGTGTGACCCCGAATC
CCAACACGACTTCTCTCCCTGCCCCAGCCACACCGGCTGAAGGAGAGGAACCCAGCACTTCGGGTACACAGCAGCTCCCAGCGGCTGCCC
AGGCCCCCGACGCTCTGCCTGCTGGATGGGAACAGCGAGAGCTGCCCAACGGACGTGTCTATTATGTTGACCACAATACCAAGACCACCA
CCTGGGAGCGGCCCCTTCCTCCAGGCTGGGAAAAACGCACAGATCCCCGAGGCAGGTTTTACTATGTGGATCACAATACTCGGACCACCA
CCTGGCAGCGTCCGACCGCGGAGTACGTGCGCAACTATGAGCAGTGGCAGTCGCAGCGGAATCAGCTCCAGGGGGCCATGCAGCACTTCA
GCCAAAGATTCCTCTACCAGTCTTCGAGTGCTTCGACTGACCATGATCCCCTGGGCCCCCTCCCTCCTGGCTGGGAGAAGAGACAGGACA
ATGGACGGGTGTATTACGTGAACCATAACACTCGCACGACCCAGTGGGAGGATCCCCGGACCCAGGGGATGATCCAGGAACCAGCTCTGC
CCCCAGGATGGGAGATGAAATACACCAGCGAGGGGGTGCGATACTTTGTGGACCACAATACCCGCACCACCACCTTTAAGGATCCTCGCC
CGGGGTTTGAGTCGGGGACGAAGCAAGGTTCCCCTGGTGCTTATGACCGCAGTTTTCGGTGGAAGTATCACCAGTTCCGTTTCCTCTGCC
ATTCAAATGCCCTACCTAGCCACGTGAAGATCAGCGTTTCCAGGCAGACGCTTTTCGAAGATTCCTTCCAACAGATCATGAACATGAAAC
CCTATGACCTGCGCCGCCGGCTCTACATCATCATGCGTGGCGAGGAGGGCCTGGACTATGGGGGCATCGCCAGAGAGTGGTTTTTCCTCC
TGTCTCATGAGGTGCTCAACCCTATGTATTGTTTATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCA
TCAACCCGGACCACCTCACCTACTTTCGCTTTATAGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCA
CCCTCCCTTTCTACAAGCGGATGCTCAATAAGAGACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCT
GGATCAAAGAGAACAACCTGGAAGAATGTGGCCTGGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGC
TGAAGGAGGGCGGCGAGAGCATCCGGGTCACAGAGGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCG
TGGAAGAGCAGACCAAAGCCTTCCTGGATGGCTTCAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGC
TGATGCTGTGCGGCATGCAGGAGATAGACATGAGCGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCC
AGTGGTTCTGGCAGGTGGTGAAGGAGATGGACAACGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCG
GGGGATTTGCCGAACTCATCGGTAGCAACGGACCACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACA
CCTGCATTGAGGAGACCGAGGGCTTTGGACAGGAGTAACCGAGGCCGCCCCTCCCACGCCCCCCAGCGCACATGTAGTCCTGAGTCCTCC
CTGCCTGAGAGGCCACTGGCCCCGCAGCCCTTGGGAGGCCCCCGTGGATGTGGCCCTGTGTGGGACCACACTGTCATCTCGCTGCTGGCA
GAAAAGCCTGATCCCAGGAGGCCCTGCAGTTCCCCCGACCCGCGGATGGCAGTCTGGAATAAAGCCCCCTAGTTGCCTTTGGCCCCACCT
TTGCAAAGTTCCAGAGGGCTGACCCTCTCTGCAAAACTCTCCCCTGTCCTCTAGACCCCACCCTGGGTGTATGTGAGTGTGCAAGGGAAG
GTGTTGCATCCCCAGGGGCTGCCGCAGAGGCCGGAGACCTCCTGGACTAGTTCGGCGAGGAGACTGGCCACTGGGGGTGGCTGTTCGGGA
CTGAGAGCGCCAAGGGTCTTTGCCAGCAAAGGAGGTTCTGCCTGTAATTGAGCCTCTCTGATGATGGAGATGAAGTGAAGGTCTGAGGGA
GCGGGCCCTGGGGCGAGGCCATCTCTGCCTGCCTCCCTAGCAGGCGCCAGCGGTGGAGGCTGAGTCGCAGGACACATGCCGGCCAGTTAA
TTCATTCTCAGCCAATGAAGGTTTGTCTAAGCTGCCTGGGTATCCACGGGACAAAAACAGCAAACTCCCTCAGACTTTGTCCATGTATAA
ACTTGAAGTGGTTGTGTTGTAGGGTTGCAGGTTTTTTGTTACGCTGCTGTCACTTTCTGTCCAGGAGCTGGCACCCCAGGTGTTCTGAGA
CCTTGAGGGACCCAGACCTTTGGGTCCAAGAGTTTCCCAAACAGCCACGCCTCTCAGGAACCCACCTGGCGGTTCCGTGAGCTCAGGCAG
GCCTGACCCGGCGGCACAGCCTGGCAGGGACCTCGTCCCCAAGCCTGGCAGAATGAGAGGGGTTGAGGTCCCGAGCGCCACTCCTAGCCT
TGCCGCCTTCAATAGAGAAGAAATCCCTTTGCTAGATAGGGTCCCCCAGGCAGTCCCCAGTGGCGGGACACAGGGGTCCGGCTGTGGAGC
TCCCCTGCCAGCCCCTGGAGCTCCAGGAGGGCCTGTTGGTCCCCTGTTCAGAATGGAGTGCAGCCCGCCAGCGGAAAGTGTTCATTCTGC
ATAGGTGTGAGGCTTTATCTGCACACAGGACATGAAAACCAGCAGAAAGGCCCTGAGCTGCTGCATAGCCCCATCTGATTTCTGCAGTTC
CCGCCAGCCTCCAACACGGGGACTCTGCCGTAACTGGAATCTTCATAGGTCATATTGAAATCTTCAAGGTGACCATGCCCCACCGGGGTG
CTGGGGCAGTAGTCATGGCAGACTCCCGGCCTGGGCCCCCAGGATTCTAGGACCCCCAGGCAGCCCCTTGGACTGGTCCCGGGTGCCTTC
CAAGCACAGTCTCCATGCTCCCAGATTCTCGACCTTCCCCCGGCCCGGGAGGTGCAGCCTGCGTCTGCCTCTGTCGTGTGTGCTGATTTG
AGTGGCTTAGCTTGCCACAGCGCAGCCTCTTCTGTCCCTTTCAGTCATTTGCTGTACTTCCCTGTGGCACGTTACCATGGAAGCCGCTCC
AGGGTGGGTCAGGGTGCAAGCTGCTGGTGAGGTTTGGAAGCATCAGGCTCACGGGTGTTCATGTGTGTTCGTGCGTGTGTGTGCGTACGT
GTATATAACTGAAGTGTCTGTACGGAATGCCCTTTGCTAGCCATGGGCTGGTCACCAGATTGTTTTGTAATGCCCGCCCCTTGCCTCGAT
ATTGCCAGTTTCTTGTGCAATAAACAATCAGCAGCTGTGAGAATCACGTCCTGGAACTGCATGTTCTTGCGACTCTTGGGACTTCATCTT
AACTTCTCGCTGCCCCAGCCATGTTTTCAACCATGGCATCCCTCCCCCAATTAGTTCCCTGTCATCCTCGTCAACCTTCTCTGTAAGTGC
CTGGTAAGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTAC
TGGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGGGAGTGTACCAACACGTCACCGGAGAGATGATG
GGTGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAGAATGGCACACCCTACTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGT
GACAATGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCATGGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTC

>99524_99524_5_WWP2-CTSB_WWP2_chr16_69973809_ENST00000359154_CTSB_chr8_11705230_ENST00000531089_length(amino acids)=858AA_BP=
MWPRQLHGDDMASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSH
LDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSG
TAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAP
LSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVD
HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGM
IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQ
QIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGK
FIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD
WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTG

--------------------------------------------------------------
>99524_99524_6_WWP2-CTSB_WWP2_chr16_69973809_ENST00000568684_CTSB_chr8_11705230_ENST00000353047_length(transcript)=6594nt_BP=3606nt
CCCCTCCTGCGTGTGGTTCTTGGAGAAAGTTGGAGGTGGTGGTGATTTCAGTCGCCTTGGCCGCCTTGAGCCGGAGCTGAGCGGAGGCAC
TGGGCCGAGCCTGCTTCCCGGGCCTTCCTACCATGCCAGGGCTGCTCCCTGCCTCCGCCACCCTGGCACACCTTCACCCGCGTACCGCCT
CCTCCCCGTCGCTCTGCCTTTTCCAAAACTCACTTGGGCCCTCCGTGCGCAGGGTTCTTTTTTGGTTTTTCTGTAAAAATCAAAACAAAA
AACAGAGACTTTTGAGAGGAGCAGATGCCACCTAAAGTCCCACTGCATTCCCTGCAAAGCGCTCAAATGTGGAAGCCAGTCATTGGCATT
TTTATTTTTTATTGATTGATTGATTTTTTCACCAGTGGCTTTTTGTAACCTCTGTGTTCTGCTGTGTTTCTTGTGTTTAGTCTTCGAGTG
CTTCGACTGACCATGATCCCCTGGGCCCCCTCCCTCCTGGCTGGGAGAAGAGACAGGACAATGGACGGGTGTATTACGTGAACCATAACA
CTCGCACGACCCAGTGGGAGGATCCCCGGACCCAGGGGATGATCCAGGAACCAGCTCTGCCCCCAGGATGGGAGATGAAATACACCAGCG
AGGGGGTGCGATACTTTGTGGACCACAATACCCGCACCACCACCTTTAAGGATCCTCGCCCGGGGTTTGAGTCGGGGACGAAGCAAGGTT
CCCCTGGTGCTTATGACCGCAGTTTTCGGTGGAAGTATCACCAGTTCCGTTTCCTCTGCCATTCAAATGCCCTACCTAGCCACGTGAAGA
TCAGCGTTTCCAGGCAGACGCTTTTCGAAGATTCCTTCCAACAGATCATGAACATGAAACCCTATGACCTGCGCCGCCGGCTCTACATCA
TCATGCGTGGCGAGGAGGGCCTGGACTATGGGGGCATCGCCAGAGAGTGGTTTTTCCTCCTGTCTCATGAGGTGCTCAACCCTATGTATT
GTTTATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCATCAACCCGGACCACCTCACCTACTTTCGCT
TTATAGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCACCCTCCCTTTCTACAAGCGGATGCTCAATA
AGAGACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCTGGATCAAAGAGAACAACCTGGAAGAATGTG
GCCTGGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGCTGAAGGAGGGCGGCGAGAGCATCCGGGTCA
CAGAGGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCGTGGAAGAGCAGACCAAAGCCTTCCTGGATG
GCTTCAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGCTGATGCTGTGCGGCATGCAGGAGATAGACA
TGAGCGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCCAGTGGTTCTGGCAGGTGGTGAAGGAGATGG
ACAACGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCGGGGGATTTGCCGAACTCATCGGTAGCAACG
GACCACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACACCTGCATTGAGGAGACCGAGGGCTTTGGAC
AGGAGTAACCGAGGCCGCCCCTCCCACGCCCCCCAGCGCACATGTAGTCCTGAGTCCTCCCTGCCTGAGAGGCCACTGGCCCCGCAGCCC
TTGGGAGGCCCCCGTGGATGTGGCCCTGTGTGGGACCACACTGTCATCTCGCTGCTGGCAGAAAAGCCTGATCCCAGGAGGCCCTGCAGT
TCCCCCGACCCGCGGATGGCAGTCTGGAATAAAGCCCCCTAGTTGCCTTTGGCCCCACCTTTGCAAAGTTCCAGAGGGCTGACCCTCTCT
GCAAAACTCTCCCCTGTCCTCTAGACCCCACCCTGGGTGTATGTGAGTGTGCAAGGGAAGGTGTTGCATCCCCAGGGGCTGCCGCAGAGG
CCGGAGACCTCCTGGACTAGTTCGGCGAGGAGACTGGCCACTGGGGGTGGCTGTTCGGGACTGAGAGCGCCAAGGGTCTTTGCCAGCAAA
GGAGGTTCTGCCTGTAATTGAGCCTCTCTGATGATGGAGATGAAGTGAAGGTCTGAGGGAGCGGGCCCTGGGGCGAGGCCATCTCTGCCT
GCCTCCCTAGCAGGCGCCAGCGGTGGAGGCTGAGTCGCAGGACACATGCCGGCCAGTTAATTCATTCTCAGCCAATGAAGGTTTGTCTAA
GCTGCCTGGGTATCCACGGGACAAAAACAGCAAACTCCCTCAGACTTTGTCCATGTATAAACTTGAAGTGGTTGTGTTGTAGGGTTGCAG
GTTTTTTGTTACGCTGCTGTCACTTTCTGTCCAGGAGCTGGCACCCCAGGTGTTCTGAGACCTTGAGGGACCCAGACCTTTGGGTCCAAG
AGTTTCCCAAACAGCCACGCCTCTCAGGAACCCACCTGGCGGTTCCGTGAGCTCAGGCAGGCCTGACCCGGCGGCACAGCCTGGCAGGGA
CCTCGTCCCCAAGCCTGGCAGAATGAGAGGGGTTGAGGTCCCGAGCGCCACTCCTAGCCTTGCCGCCTTCAATAGAGAAGAAATCCCTTT
GCTAGATAGGGTCCCCCAGGCAGTCCCCAGTGGCGGGACACAGGGGTCCGGCTGTGGAGCTCCCCTGCCAGCCCCTGGAGCTCCAGGAGG
GCCTGTTGGTCCCCTGTTCAGAATGGAGTGCAGCCCGCCAGCGGAAAGTGTTCATTCTGCATAGGTGTGAGGCTTTATCTGCACACAGGA
CATGAAAACCAGCAGAAAGGCCCTGAGCTGCTGCATAGCCCCATCTGATTTCTGCAGTTCCCGCCAGCCTCCAACACGGGGACTCTGCCG
TAACTGGAATCTTCATAGGTCATATTGAAATCTTCAAGGTGACCATGCCCCACCGGGGTGCTGGGGCAGTAGTCATGGCAGACTCCCGGC
CTGGGCCCCCAGGATTCTAGGACCCCCAGGCAGCCCCTTGGACTGGTCCCGGGTGCCTTCCAAGCACAGTCTCCATGCTCCCAGATTCTC
GACCTTCCCCCGGCCCGGGAGGTGCAGCCTGCGTCTGCCTCTGTCGTGTGTGCTGATTTGAGTGGCTTAGCTTGCCACAGCGCAGCCTCT
TCTGTCCCTTTCAGTCATTTGCTGTACTTCCCTGTGGCACGTTACCATGGAAGCCGCTCCAGGGTGGGTCAGGGTGCAAGCTGCTGGTGA
GGTTTGGAAGCATCAGGCTCACGGGTGTTCATGTGTGTTCGTGCGTGTGTGTGCGTACGTGTATATAACTGAAGTGTCTGTACGGAATGC
CCTTTGCTAGCCATGGGCTGGTCACCAGATTGTTTTGTAATGCCCGCCCCTTGCCTCGATATTGCCAGTTTCTTGTGCAATAAACAATCA
GCAGCTGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTACT
GGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGGGTAGAAATGCATTTTATTCTTTAAGTTCACGTA
AGATACAAGTTTCAGACAGGGTCTGAAGGACTGGATTGGCCAAACATCAGACCTGTCTTCCAAGGAGACCAAGTCCTGGCTACATCCCAG
CCTGTGGTTACAGTGCAGACAGGCCATGTGAGCCACCGCTGCCAGCACAGAGCGTCCTTCCCCCTGTAGACTAGTGCCGTAGGGAGTACC
TGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCATCTCCAGGGAGCAAGACAGAGACGCAGGAATGGAAAGCGGAGTTCCTAA
CAGGATGAAAGTTCCCCCATCAGTTCCCCCAGTACCTCCAAGCAAGTAGCTTTCCACATTTGTCACAGAAATCAGAGGAGAGACGGTGTT
GGGAGCCCTTTGGAGAACGCCAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAATGTCACAACCTCTCTGATCTTGTGCTCAGCATG
ATTCTTTAATAGAAGTTTTATTTTTTCGTGCACTCTGCTAATCATGTGGGTGAGCCAGTGGAACAGCGGGAGACCTGTGCTAGTTTTACA
GATTGCCTCCTTATGACGCGGCTCAAAAGGAAACCAAGTGGTCAGGAGTTGTTTCTGACCCACTGATCTCTACTACCACAAGGAAAATAG
TTTAGGAGAAACCAGCTTTTACTGTTTTTGAAAAATTACAGCTTCACCCTGTCAAGTTAACAAGGAATGCCTGTGCCAATAAAAGTTTTC
TCCAACTTGAAGTCTACTCTGATGGGATCTCAGATCCTTTGTCACTGCCTATAGACTTGTAGCTGCTGTCTCTCTTTGTCCCTGCAGAGA
ATCACGTCCTGGAACTGCATGTTCTTGCGACTCTTGGGACTTCATCTTAACTTCTCGCTGCCCCAGCCATGTTTTCAACCATGGCATCCC
TCCCCCAATTAGTTCCCTGTCATCCTCGTCAACCTTCTCTGTAAGTGCCTGGTAAGCTTGCCCTTGCTTAAGAACTCAAAACATAGCTGT
GCTCTATTTTTTTGTTGTTGTTGTGACTGACAGAGTGAGATTCCGTCTCCCAGGCTGGAGTGCAGTGGCGCCTTCTCAGCTCACTGCAAC
CTGCAGCCTCCTAGATTCAAGCGATTCTCCTGCTTCAGCCTTCCGAGTAGCTGGGATGACAGGCACTCACCAATATGCCTGGGTAATTTT
TGTATTTTTAAGTACATACAGGATTTCACCATGTTGGCCAGGCTAGTTTCAAACTCCCGGCCTCAGGTGGTCTGCCTGCCTCAGCCTCCC
AAAGTGTTGGGATTACAGGCGTGAGCCACTGGGCCCTGCCTGTATTTTTTATCAGCCACAAATCCAGCAACAAGCTGAGGATTCAGCTCA
TAAAACAGGCTTGGTGTCTTGGTGATCTCACATAACCAAGATGCTACCCCGTGGGGAACCACATCCCCCTGGATGCCCTCCAGCCTTGGT
TTGGGCTGGAGTCAGGGCCTGTATACAGTATTTTGAATTTGTATGCCACTGGTTTGCATTGCTGGTCAGGAACTCTAGTGCTTTGCATAG
CCCTGGTTTAGAAACATGTTATAGCAGTTCTTGGTATAGAGCAAACTAGAAGAACCAGCAATCATTCCACTGTCCTGCCAAGGTACACCT
CAGTACTCCCCTTCCCAACTGAAGTGGTATGAGGCTAGCTCTTTCCAAAAGCATTCAAGTTTGGCTTCTGATGTGACTCAGAATTTAGGA
ACCAGATGCTAGATCAAATAAGCTCTGAAAATCTGAGGAACATTGTAGGAAAGGTTTGTTAAGCATCTCTTAAGTGCCATGATGAGCATA
ACAGCCGGCCGTCGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGAGGATGACAAGGTCAGGAGTTCAAGACCAGCC
TGGCCAACATGCTGAAACCTCACCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAG
GCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGACAGTGCCAGTGCACTCCAGCCTCGGTGACAGCGCA
AGGCTCCGTCTCAATAATTAAAAAAAAAAAAAAAAAAAAAAAGGCCGGGCGCAGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCT
GAGGCGGGCAGATCACCTGAGGTCAGGAGTTTTGAGATCAGCCTTGGCAACACGGTGAAACCCCATCTCTACTAAAAATACAAAATTAGC
CAAGCATGCTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGTACGAGAATCGCTTGAACCTGGGAGGCAGAGGATGCAGTGA
GCCGAGATCACGCCATTGCACTCCAGCCTGGGGGACAAGAGTGAATCTGTGTCTCACCAAAAAAAAAAAGAAAAAGAAAGATGCTTAACA
AAGGTTACCATAAGCCACAAATTCATAACCACTTATCCTTCCAGTTTCAAGTAGAATATATTCATAACCTCAATAAAGTTCTCCCTGCTC
CCAAAGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAGAATGGCACACCCTA
CTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACAATGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCATGGC
CGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACTTCCTGCTCTACAAGTCAGGAGCCTGGCTACAGCCCGA

>99524_99524_6_WWP2-CTSB_WWP2_chr16_69973809_ENST00000568684_CTSB_chr8_11705230_ENST00000353047_length(amino acids)=445AA_BP=
MGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDR
SFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAG
KNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFI
QDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKS

--------------------------------------------------------------
>99524_99524_7_WWP2-CTSB_WWP2_chr16_69973809_ENST00000568684_CTSB_chr8_11705230_ENST00000434271_length(transcript)=6594nt_BP=3606nt
CCCCTCCTGCGTGTGGTTCTTGGAGAAAGTTGGAGGTGGTGGTGATTTCAGTCGCCTTGGCCGCCTTGAGCCGGAGCTGAGCGGAGGCAC
TGGGCCGAGCCTGCTTCCCGGGCCTTCCTACCATGCCAGGGCTGCTCCCTGCCTCCGCCACCCTGGCACACCTTCACCCGCGTACCGCCT
CCTCCCCGTCGCTCTGCCTTTTCCAAAACTCACTTGGGCCCTCCGTGCGCAGGGTTCTTTTTTGGTTTTTCTGTAAAAATCAAAACAAAA
AACAGAGACTTTTGAGAGGAGCAGATGCCACCTAAAGTCCCACTGCATTCCCTGCAAAGCGCTCAAATGTGGAAGCCAGTCATTGGCATT
TTTATTTTTTATTGATTGATTGATTTTTTCACCAGTGGCTTTTTGTAACCTCTGTGTTCTGCTGTGTTTCTTGTGTTTAGTCTTCGAGTG
CTTCGACTGACCATGATCCCCTGGGCCCCCTCCCTCCTGGCTGGGAGAAGAGACAGGACAATGGACGGGTGTATTACGTGAACCATAACA
CTCGCACGACCCAGTGGGAGGATCCCCGGACCCAGGGGATGATCCAGGAACCAGCTCTGCCCCCAGGATGGGAGATGAAATACACCAGCG
AGGGGGTGCGATACTTTGTGGACCACAATACCCGCACCACCACCTTTAAGGATCCTCGCCCGGGGTTTGAGTCGGGGACGAAGCAAGGTT
CCCCTGGTGCTTATGACCGCAGTTTTCGGTGGAAGTATCACCAGTTCCGTTTCCTCTGCCATTCAAATGCCCTACCTAGCCACGTGAAGA
TCAGCGTTTCCAGGCAGACGCTTTTCGAAGATTCCTTCCAACAGATCATGAACATGAAACCCTATGACCTGCGCCGCCGGCTCTACATCA
TCATGCGTGGCGAGGAGGGCCTGGACTATGGGGGCATCGCCAGAGAGTGGTTTTTCCTCCTGTCTCATGAGGTGCTCAACCCTATGTATT
GTTTATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCATCAACCCGGACCACCTCACCTACTTTCGCT
TTATAGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCACCCTCCCTTTCTACAAGCGGATGCTCAATA
AGAGACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCTGGATCAAAGAGAACAACCTGGAAGAATGTG
GCCTGGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGCTGAAGGAGGGCGGCGAGAGCATCCGGGTCA
CAGAGGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCGTGGAAGAGCAGACCAAAGCCTTCCTGGATG
GCTTCAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGCTGATGCTGTGCGGCATGCAGGAGATAGACA
TGAGCGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCCAGTGGTTCTGGCAGGTGGTGAAGGAGATGG
ACAACGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCGGGGGATTTGCCGAACTCATCGGTAGCAACG
GACCACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACACCTGCATTGAGGAGACCGAGGGCTTTGGAC
AGGAGTAACCGAGGCCGCCCCTCCCACGCCCCCCAGCGCACATGTAGTCCTGAGTCCTCCCTGCCTGAGAGGCCACTGGCCCCGCAGCCC
TTGGGAGGCCCCCGTGGATGTGGCCCTGTGTGGGACCACACTGTCATCTCGCTGCTGGCAGAAAAGCCTGATCCCAGGAGGCCCTGCAGT
TCCCCCGACCCGCGGATGGCAGTCTGGAATAAAGCCCCCTAGTTGCCTTTGGCCCCACCTTTGCAAAGTTCCAGAGGGCTGACCCTCTCT
GCAAAACTCTCCCCTGTCCTCTAGACCCCACCCTGGGTGTATGTGAGTGTGCAAGGGAAGGTGTTGCATCCCCAGGGGCTGCCGCAGAGG
CCGGAGACCTCCTGGACTAGTTCGGCGAGGAGACTGGCCACTGGGGGTGGCTGTTCGGGACTGAGAGCGCCAAGGGTCTTTGCCAGCAAA
GGAGGTTCTGCCTGTAATTGAGCCTCTCTGATGATGGAGATGAAGTGAAGGTCTGAGGGAGCGGGCCCTGGGGCGAGGCCATCTCTGCCT
GCCTCCCTAGCAGGCGCCAGCGGTGGAGGCTGAGTCGCAGGACACATGCCGGCCAGTTAATTCATTCTCAGCCAATGAAGGTTTGTCTAA
GCTGCCTGGGTATCCACGGGACAAAAACAGCAAACTCCCTCAGACTTTGTCCATGTATAAACTTGAAGTGGTTGTGTTGTAGGGTTGCAG
GTTTTTTGTTACGCTGCTGTCACTTTCTGTCCAGGAGCTGGCACCCCAGGTGTTCTGAGACCTTGAGGGACCCAGACCTTTGGGTCCAAG
AGTTTCCCAAACAGCCACGCCTCTCAGGAACCCACCTGGCGGTTCCGTGAGCTCAGGCAGGCCTGACCCGGCGGCACAGCCTGGCAGGGA
CCTCGTCCCCAAGCCTGGCAGAATGAGAGGGGTTGAGGTCCCGAGCGCCACTCCTAGCCTTGCCGCCTTCAATAGAGAAGAAATCCCTTT
GCTAGATAGGGTCCCCCAGGCAGTCCCCAGTGGCGGGACACAGGGGTCCGGCTGTGGAGCTCCCCTGCCAGCCCCTGGAGCTCCAGGAGG
GCCTGTTGGTCCCCTGTTCAGAATGGAGTGCAGCCCGCCAGCGGAAAGTGTTCATTCTGCATAGGTGTGAGGCTTTATCTGCACACAGGA
CATGAAAACCAGCAGAAAGGCCCTGAGCTGCTGCATAGCCCCATCTGATTTCTGCAGTTCCCGCCAGCCTCCAACACGGGGACTCTGCCG
TAACTGGAATCTTCATAGGTCATATTGAAATCTTCAAGGTGACCATGCCCCACCGGGGTGCTGGGGCAGTAGTCATGGCAGACTCCCGGC
CTGGGCCCCCAGGATTCTAGGACCCCCAGGCAGCCCCTTGGACTGGTCCCGGGTGCCTTCCAAGCACAGTCTCCATGCTCCCAGATTCTC
GACCTTCCCCCGGCCCGGGAGGTGCAGCCTGCGTCTGCCTCTGTCGTGTGTGCTGATTTGAGTGGCTTAGCTTGCCACAGCGCAGCCTCT
TCTGTCCCTTTCAGTCATTTGCTGTACTTCCCTGTGGCACGTTACCATGGAAGCCGCTCCAGGGTGGGTCAGGGTGCAAGCTGCTGGTGA
GGTTTGGAAGCATCAGGCTCACGGGTGTTCATGTGTGTTCGTGCGTGTGTGTGCGTACGTGTATATAACTGAAGTGTCTGTACGGAATGC
CCTTTGCTAGCCATGGGCTGGTCACCAGATTGTTTTGTAATGCCCGCCCCTTGCCTCGATATTGCCAGTTTCTTGTGCAATAAACAATCA
GCAGCTGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTACT
GGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGGGTAGAAATGCATTTTATTCTTTAAGTTCACGTA
AGATACAAGTTTCAGACAGGGTCTGAAGGACTGGATTGGCCAAACATCAGACCTGTCTTCCAAGGAGACCAAGTCCTGGCTACATCCCAG
CCTGTGGTTACAGTGCAGACAGGCCATGTGAGCCACCGCTGCCAGCACAGAGCGTCCTTCCCCCTGTAGACTAGTGCCGTAGGGAGTACC
TGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCATCTCCAGGGAGCAAGACAGAGACGCAGGAATGGAAAGCGGAGTTCCTAA
CAGGATGAAAGTTCCCCCATCAGTTCCCCCAGTACCTCCAAGCAAGTAGCTTTCCACATTTGTCACAGAAATCAGAGGAGAGACGGTGTT
GGGAGCCCTTTGGAGAACGCCAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAATGTCACAACCTCTCTGATCTTGTGCTCAGCATG
ATTCTTTAATAGAAGTTTTATTTTTTCGTGCACTCTGCTAATCATGTGGGTGAGCCAGTGGAACAGCGGGAGACCTGTGCTAGTTTTACA
GATTGCCTCCTTATGACGCGGCTCAAAAGGAAACCAAGTGGTCAGGAGTTGTTTCTGACCCACTGATCTCTACTACCACAAGGAAAATAG
TTTAGGAGAAACCAGCTTTTACTGTTTTTGAAAAATTACAGCTTCACCCTGTCAAGTTAACAAGGAATGCCTGTGCCAATAAAAGTTTTC
TCCAACTTGAAGTCTACTCTGATGGGATCTCAGATCCTTTGTCACTGCCTATAGACTTGTAGCTGCTGTCTCTCTTTGTCCCTGCAGAGA
ATCACGTCCTGGAACTGCATGTTCTTGCGACTCTTGGGACTTCATCTTAACTTCTCGCTGCCCCAGCCATGTTTTCAACCATGGCATCCC
TCCCCCAATTAGTTCCCTGTCATCCTCGTCAACCTTCTCTGTAAGTGCCTGGTAAGCTTGCCCTTGCTTAAGAACTCAAAACATAGCTGT
GCTCTATTTTTTTGTTGTTGTTGTGACTGACAGAGTGAGATTCCGTCTCCCAGGCTGGAGTGCAGTGGCGCCTTCTCAGCTCACTGCAAC
CTGCAGCCTCCTAGATTCAAGCGATTCTCCTGCTTCAGCCTTCCGAGTAGCTGGGATGACAGGCACTCACCAATATGCCTGGGTAATTTT
TGTATTTTTAAGTACATACAGGATTTCACCATGTTGGCCAGGCTAGTTTCAAACTCCCGGCCTCAGGTGGTCTGCCTGCCTCAGCCTCCC
AAAGTGTTGGGATTACAGGCGTGAGCCACTGGGCCCTGCCTGTATTTTTTATCAGCCACAAATCCAGCAACAAGCTGAGGATTCAGCTCA
TAAAACAGGCTTGGTGTCTTGGTGATCTCACATAACCAAGATGCTACCCCGTGGGGAACCACATCCCCCTGGATGCCCTCCAGCCTTGGT
TTGGGCTGGAGTCAGGGCCTGTATACAGTATTTTGAATTTGTATGCCACTGGTTTGCATTGCTGGTCAGGAACTCTAGTGCTTTGCATAG
CCCTGGTTTAGAAACATGTTATAGCAGTTCTTGGTATAGAGCAAACTAGAAGAACCAGCAATCATTCCACTGTCCTGCCAAGGTACACCT
CAGTACTCCCCTTCCCAACTGAAGTGGTATGAGGCTAGCTCTTTCCAAAAGCATTCAAGTTTGGCTTCTGATGTGACTCAGAATTTAGGA
ACCAGATGCTAGATCAAATAAGCTCTGAAAATCTGAGGAACATTGTAGGAAAGGTTTGTTAAGCATCTCTTAAGTGCCATGATGAGCATA
ACAGCCGGCCGTCGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGAGGATGACAAGGTCAGGAGTTCAAGACCAGCC
TGGCCAACATGCTGAAACCTCACCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAG
GCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGACAGTGCCAGTGCACTCCAGCCTCGGTGACAGCGCA
AGGCTCCGTCTCAATAATTAAAAAAAAAAAAAAAAAAAAAAAGGCCGGGCGCAGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCT
GAGGCGGGCAGATCACCTGAGGTCAGGAGTTTTGAGATCAGCCTTGGCAACACGGTGAAACCCCATCTCTACTAAAAATACAAAATTAGC
CAAGCATGCTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGTACGAGAATCGCTTGAACCTGGGAGGCAGAGGATGCAGTGA
GCCGAGATCACGCCATTGCACTCCAGCCTGGGGGACAAGAGTGAATCTGTGTCTCACCAAAAAAAAAAAGAAAAAGAAAGATGCTTAACA
AAGGTTACCATAAGCCACAAATTCATAACCACTTATCCTTCCAGTTTCAAGTAGAATATATTCATAACCTCAATAAAGTTCTCCCTGCTC
CCAAAGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAGAATGGCACACCCTA
CTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACAATGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCATGGC
CGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACTTCCTGCTCTACAAGTCAGGAGCCTGGCTACAGCCCGA

>99524_99524_7_WWP2-CTSB_WWP2_chr16_69973809_ENST00000568684_CTSB_chr8_11705230_ENST00000434271_length(amino acids)=445AA_BP=
MGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDR
SFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAG
KNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFI
QDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKS

--------------------------------------------------------------
>99524_99524_8_WWP2-CTSB_WWP2_chr16_69973809_ENST00000568684_CTSB_chr8_11705230_ENST00000453527_length(transcript)=4798nt_BP=3606nt
CCCCTCCTGCGTGTGGTTCTTGGAGAAAGTTGGAGGTGGTGGTGATTTCAGTCGCCTTGGCCGCCTTGAGCCGGAGCTGAGCGGAGGCAC
TGGGCCGAGCCTGCTTCCCGGGCCTTCCTACCATGCCAGGGCTGCTCCCTGCCTCCGCCACCCTGGCACACCTTCACCCGCGTACCGCCT
CCTCCCCGTCGCTCTGCCTTTTCCAAAACTCACTTGGGCCCTCCGTGCGCAGGGTTCTTTTTTGGTTTTTCTGTAAAAATCAAAACAAAA
AACAGAGACTTTTGAGAGGAGCAGATGCCACCTAAAGTCCCACTGCATTCCCTGCAAAGCGCTCAAATGTGGAAGCCAGTCATTGGCATT
TTTATTTTTTATTGATTGATTGATTTTTTCACCAGTGGCTTTTTGTAACCTCTGTGTTCTGCTGTGTTTCTTGTGTTTAGTCTTCGAGTG
CTTCGACTGACCATGATCCCCTGGGCCCCCTCCCTCCTGGCTGGGAGAAGAGACAGGACAATGGACGGGTGTATTACGTGAACCATAACA
CTCGCACGACCCAGTGGGAGGATCCCCGGACCCAGGGGATGATCCAGGAACCAGCTCTGCCCCCAGGATGGGAGATGAAATACACCAGCG
AGGGGGTGCGATACTTTGTGGACCACAATACCCGCACCACCACCTTTAAGGATCCTCGCCCGGGGTTTGAGTCGGGGACGAAGCAAGGTT
CCCCTGGTGCTTATGACCGCAGTTTTCGGTGGAAGTATCACCAGTTCCGTTTCCTCTGCCATTCAAATGCCCTACCTAGCCACGTGAAGA
TCAGCGTTTCCAGGCAGACGCTTTTCGAAGATTCCTTCCAACAGATCATGAACATGAAACCCTATGACCTGCGCCGCCGGCTCTACATCA
TCATGCGTGGCGAGGAGGGCCTGGACTATGGGGGCATCGCCAGAGAGTGGTTTTTCCTCCTGTCTCATGAGGTGCTCAACCCTATGTATT
GTTTATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCATCAACCCGGACCACCTCACCTACTTTCGCT
TTATAGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCACCCTCCCTTTCTACAAGCGGATGCTCAATA
AGAGACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCTGGATCAAAGAGAACAACCTGGAAGAATGTG
GCCTGGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGCTGAAGGAGGGCGGCGAGAGCATCCGGGTCA
CAGAGGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCGTGGAAGAGCAGACCAAAGCCTTCCTGGATG
GCTTCAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGCTGATGCTGTGCGGCATGCAGGAGATAGACA
TGAGCGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCCAGTGGTTCTGGCAGGTGGTGAAGGAGATGG
ACAACGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCGGGGGATTTGCCGAACTCATCGGTAGCAACG
GACCACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACACCTGCATTGAGGAGACCGAGGGCTTTGGAC
AGGAGTAACCGAGGCCGCCCCTCCCACGCCCCCCAGCGCACATGTAGTCCTGAGTCCTCCCTGCCTGAGAGGCCACTGGCCCCGCAGCCC
TTGGGAGGCCCCCGTGGATGTGGCCCTGTGTGGGACCACACTGTCATCTCGCTGCTGGCAGAAAAGCCTGATCCCAGGAGGCCCTGCAGT
TCCCCCGACCCGCGGATGGCAGTCTGGAATAAAGCCCCCTAGTTGCCTTTGGCCCCACCTTTGCAAAGTTCCAGAGGGCTGACCCTCTCT
GCAAAACTCTCCCCTGTCCTCTAGACCCCACCCTGGGTGTATGTGAGTGTGCAAGGGAAGGTGTTGCATCCCCAGGGGCTGCCGCAGAGG
CCGGAGACCTCCTGGACTAGTTCGGCGAGGAGACTGGCCACTGGGGGTGGCTGTTCGGGACTGAGAGCGCCAAGGGTCTTTGCCAGCAAA
GGAGGTTCTGCCTGTAATTGAGCCTCTCTGATGATGGAGATGAAGTGAAGGTCTGAGGGAGCGGGCCCTGGGGCGAGGCCATCTCTGCCT
GCCTCCCTAGCAGGCGCCAGCGGTGGAGGCTGAGTCGCAGGACACATGCCGGCCAGTTAATTCATTCTCAGCCAATGAAGGTTTGTCTAA
GCTGCCTGGGTATCCACGGGACAAAAACAGCAAACTCCCTCAGACTTTGTCCATGTATAAACTTGAAGTGGTTGTGTTGTAGGGTTGCAG
GTTTTTTGTTACGCTGCTGTCACTTTCTGTCCAGGAGCTGGCACCCCAGGTGTTCTGAGACCTTGAGGGACCCAGACCTTTGGGTCCAAG
AGTTTCCCAAACAGCCACGCCTCTCAGGAACCCACCTGGCGGTTCCGTGAGCTCAGGCAGGCCTGACCCGGCGGCACAGCCTGGCAGGGA
CCTCGTCCCCAAGCCTGGCAGAATGAGAGGGGTTGAGGTCCCGAGCGCCACTCCTAGCCTTGCCGCCTTCAATAGAGAAGAAATCCCTTT
GCTAGATAGGGTCCCCCAGGCAGTCCCCAGTGGCGGGACACAGGGGTCCGGCTGTGGAGCTCCCCTGCCAGCCCCTGGAGCTCCAGGAGG
GCCTGTTGGTCCCCTGTTCAGAATGGAGTGCAGCCCGCCAGCGGAAAGTGTTCATTCTGCATAGGTGTGAGGCTTTATCTGCACACAGGA
CATGAAAACCAGCAGAAAGGCCCTGAGCTGCTGCATAGCCCCATCTGATTTCTGCAGTTCCCGCCAGCCTCCAACACGGGGACTCTGCCG
TAACTGGAATCTTCATAGGTCATATTGAAATCTTCAAGGTGACCATGCCCCACCGGGGTGCTGGGGCAGTAGTCATGGCAGACTCCCGGC
CTGGGCCCCCAGGATTCTAGGACCCCCAGGCAGCCCCTTGGACTGGTCCCGGGTGCCTTCCAAGCACAGTCTCCATGCTCCCAGATTCTC
GACCTTCCCCCGGCCCGGGAGGTGCAGCCTGCGTCTGCCTCTGTCGTGTGTGCTGATTTGAGTGGCTTAGCTTGCCACAGCGCAGCCTCT
TCTGTCCCTTTCAGTCATTTGCTGTACTTCCCTGTGGCACGTTACCATGGAAGCCGCTCCAGGGTGGGTCAGGGTGCAAGCTGCTGGTGA
GGTTTGGAAGCATCAGGCTCACGGGTGTTCATGTGTGTTCGTGCGTGTGTGTGCGTACGTGTATATAACTGAAGTGTCTGTACGGAATGC
CCTTTGCTAGCCATGGGCTGGTCACCAGATTGTTTTGTAATGCCCGCCCCTTGCCTCGATATTGCCAGTTTCTTGTGCAATAAACAATCA
GCAGCTGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTACT
GGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGGGTAGAAATGCATTTTATTCTTTAAGTTCACGTA
AGATACAAGTTTCAGACAGGGTCTGAAGGACTGGATTGGCCAAACATCAGACCTGTCTTCCAAGGAGACCAAGTCCTGGCTACATCCCAG
CCTGTGGTTACAGTGCAGACAGGCCATGTGAGCCACCGCTGCCAGCACAGAGCGTCCTTCCCCCTGTAGACTAGTGCCGTAGGGAGTACC
TGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCATCTCCAGGGAGCAAGACAGAGACGCAGGAATGGAAAGCGGAGTTCCTAA
CAGGATGAAAGTTCCCCCATCAGTTCCCCCAGTACCTCCAAGCAAGTAGCTTTCCACATTTGTCACAGAAATCAGAGGAGAGACGGTGTT
GGGAGCCCTTTGGAGAACGCCAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAATGTCACAACCTCTCTGATCTTGTGCTCAGCATG
ATTCTTTAATAGAAGTTTTATTTTTTCGTGCACTCTGCTAATCATGTGGGTGAGCCAGTGGAACAGCGGGAGACCTGTGCTAGTTTTACA
GATTGCCTCCTTATGACGCGGCTCAAAAGGAAACCAAGTGGTCAGGAGTTGTTTCTGACCCACTGATCTCTACTACCACAAGGAAAATAG
TTTAGGAGAAACCAGCTTTTACTGTTTTTGAAAAATTACAGCTTCACCCTGTCAAGTTAACAAGGAATGCCTGTGCCAATAAAAGTTTTC
TCCAACTTGGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAGAATGGCACAC
CCTACTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACAATGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCA
TGGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACTTCCTGCTCTACAAGTCAGGAGCCTGGCTACAGC

>99524_99524_8_WWP2-CTSB_WWP2_chr16_69973809_ENST00000568684_CTSB_chr8_11705230_ENST00000453527_length(amino acids)=445AA_BP=
MGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDR
SFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAG
KNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFI
QDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKS

--------------------------------------------------------------
>99524_99524_9_WWP2-CTSB_WWP2_chr16_69973809_ENST00000568684_CTSB_chr8_11705230_ENST00000530640_length(transcript)=4225nt_BP=3606nt
CCCCTCCTGCGTGTGGTTCTTGGAGAAAGTTGGAGGTGGTGGTGATTTCAGTCGCCTTGGCCGCCTTGAGCCGGAGCTGAGCGGAGGCAC
TGGGCCGAGCCTGCTTCCCGGGCCTTCCTACCATGCCAGGGCTGCTCCCTGCCTCCGCCACCCTGGCACACCTTCACCCGCGTACCGCCT
CCTCCCCGTCGCTCTGCCTTTTCCAAAACTCACTTGGGCCCTCCGTGCGCAGGGTTCTTTTTTGGTTTTTCTGTAAAAATCAAAACAAAA
AACAGAGACTTTTGAGAGGAGCAGATGCCACCTAAAGTCCCACTGCATTCCCTGCAAAGCGCTCAAATGTGGAAGCCAGTCATTGGCATT
TTTATTTTTTATTGATTGATTGATTTTTTCACCAGTGGCTTTTTGTAACCTCTGTGTTCTGCTGTGTTTCTTGTGTTTAGTCTTCGAGTG
CTTCGACTGACCATGATCCCCTGGGCCCCCTCCCTCCTGGCTGGGAGAAGAGACAGGACAATGGACGGGTGTATTACGTGAACCATAACA
CTCGCACGACCCAGTGGGAGGATCCCCGGACCCAGGGGATGATCCAGGAACCAGCTCTGCCCCCAGGATGGGAGATGAAATACACCAGCG
AGGGGGTGCGATACTTTGTGGACCACAATACCCGCACCACCACCTTTAAGGATCCTCGCCCGGGGTTTGAGTCGGGGACGAAGCAAGGTT
CCCCTGGTGCTTATGACCGCAGTTTTCGGTGGAAGTATCACCAGTTCCGTTTCCTCTGCCATTCAAATGCCCTACCTAGCCACGTGAAGA
TCAGCGTTTCCAGGCAGACGCTTTTCGAAGATTCCTTCCAACAGATCATGAACATGAAACCCTATGACCTGCGCCGCCGGCTCTACATCA
TCATGCGTGGCGAGGAGGGCCTGGACTATGGGGGCATCGCCAGAGAGTGGTTTTTCCTCCTGTCTCATGAGGTGCTCAACCCTATGTATT
GTTTATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCATCAACCCGGACCACCTCACCTACTTTCGCT
TTATAGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCACCCTCCCTTTCTACAAGCGGATGCTCAATA
AGAGACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCTGGATCAAAGAGAACAACCTGGAAGAATGTG
GCCTGGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGCTGAAGGAGGGCGGCGAGAGCATCCGGGTCA
CAGAGGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCGTGGAAGAGCAGACCAAAGCCTTCCTGGATG
GCTTCAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGCTGATGCTGTGCGGCATGCAGGAGATAGACA
TGAGCGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCCAGTGGTTCTGGCAGGTGGTGAAGGAGATGG
ACAACGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCGGGGGATTTGCCGAACTCATCGGTAGCAACG
GACCACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACACCTGCATTGAGGAGACCGAGGGCTTTGGAC
AGGAGTAACCGAGGCCGCCCCTCCCACGCCCCCCAGCGCACATGTAGTCCTGAGTCCTCCCTGCCTGAGAGGCCACTGGCCCCGCAGCCC
TTGGGAGGCCCCCGTGGATGTGGCCCTGTGTGGGACCACACTGTCATCTCGCTGCTGGCAGAAAAGCCTGATCCCAGGAGGCCCTGCAGT
TCCCCCGACCCGCGGATGGCAGTCTGGAATAAAGCCCCCTAGTTGCCTTTGGCCCCACCTTTGCAAAGTTCCAGAGGGCTGACCCTCTCT
GCAAAACTCTCCCCTGTCCTCTAGACCCCACCCTGGGTGTATGTGAGTGTGCAAGGGAAGGTGTTGCATCCCCAGGGGCTGCCGCAGAGG
CCGGAGACCTCCTGGACTAGTTCGGCGAGGAGACTGGCCACTGGGGGTGGCTGTTCGGGACTGAGAGCGCCAAGGGTCTTTGCCAGCAAA
GGAGGTTCTGCCTGTAATTGAGCCTCTCTGATGATGGAGATGAAGTGAAGGTCTGAGGGAGCGGGCCCTGGGGCGAGGCCATCTCTGCCT
GCCTCCCTAGCAGGCGCCAGCGGTGGAGGCTGAGTCGCAGGACACATGCCGGCCAGTTAATTCATTCTCAGCCAATGAAGGTTTGTCTAA
GCTGCCTGGGTATCCACGGGACAAAAACAGCAAACTCCCTCAGACTTTGTCCATGTATAAACTTGAAGTGGTTGTGTTGTAGGGTTGCAG
GTTTTTTGTTACGCTGCTGTCACTTTCTGTCCAGGAGCTGGCACCCCAGGTGTTCTGAGACCTTGAGGGACCCAGACCTTTGGGTCCAAG
AGTTTCCCAAACAGCCACGCCTCTCAGGAACCCACCTGGCGGTTCCGTGAGCTCAGGCAGGCCTGACCCGGCGGCACAGCCTGGCAGGGA
CCTCGTCCCCAAGCCTGGCAGAATGAGAGGGGTTGAGGTCCCGAGCGCCACTCCTAGCCTTGCCGCCTTCAATAGAGAAGAAATCCCTTT
GCTAGATAGGGTCCCCCAGGCAGTCCCCAGTGGCGGGACACAGGGGTCCGGCTGTGGAGCTCCCCTGCCAGCCCCTGGAGCTCCAGGAGG
GCCTGTTGGTCCCCTGTTCAGAATGGAGTGCAGCCCGCCAGCGGAAAGTGTTCATTCTGCATAGGTGTGAGGCTTTATCTGCACACAGGA
CATGAAAACCAGCAGAAAGGCCCTGAGCTGCTGCATAGCCCCATCTGATTTCTGCAGTTCCCGCCAGCCTCCAACACGGGGACTCTGCCG
TAACTGGAATCTTCATAGGTCATATTGAAATCTTCAAGGTGACCATGCCCCACCGGGGTGCTGGGGCAGTAGTCATGGCAGACTCCCGGC
CTGGGCCCCCAGGATTCTAGGACCCCCAGGCAGCCCCTTGGACTGGTCCCGGGTGCCTTCCAAGCACAGTCTCCATGCTCCCAGATTCTC
GACCTTCCCCCGGCCCGGGAGGTGCAGCCTGCGTCTGCCTCTGTCGTGTGTGCTGATTTGAGTGGCTTAGCTTGCCACAGCGCAGCCTCT
TCTGTCCCTTTCAGTCATTTGCTGTACTTCCCTGTGGCACGTTACCATGGAAGCCGCTCCAGGGTGGGTCAGGGTGCAAGCTGCTGGTGA
GGTTTGGAAGCATCAGGCTCACGGGTGTTCATGTGTGTTCGTGCGTGTGTGTGCGTACGTGTATATAACTGAAGTGTCTGTACGGAATGC
CCTTTGCTAGCCATGGGCTGGTCACCAGATTGTTTTGTAATGCCCGCCCCTTGCCTCGATATTGCCAGTTTCTTGTGCAATAAACAATCA
GCAGCTAGAATCACGTCCTGGAACTGCATGTTCTTGCGACTCTTGGGACTTCATCTTAACTTCTCGCTGCCCCAGCCATGTTTTCAACCA
TGGCATCCCTCCCCCAATTAGTTCCCTGTCATCCTCGTCAACCTTCTCTGTAAGTGCCTGGTAAGCTTGCCCTTGCTTAAGAACTCAAAA
CATAGCTGTGCTCTAGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAGTGGTGGCTGGAATTCCACGCACCG
ATCAGTACTGGGAAAAGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGCGAGATCGGGGAGTGTACCAACACGTCACCGGAG
AGATGATGGGTGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAGAATGGCACACCCTACTGGCTGGTTGCCAACTCCTGGAACACTG
ACTGGGGTGACAATGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCATGGCCGAGATCTACAAAAACGGCCCCGTGGAGG

>99524_99524_9_WWP2-CTSB_WWP2_chr16_69973809_ENST00000568684_CTSB_chr8_11705230_ENST00000530640_length(amino acids)=445AA_BP=
MGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDR
SFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAG
KNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFI
QDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKS

--------------------------------------------------------------
>99524_99524_10_WWP2-CTSB_WWP2_chr16_69973809_ENST00000568684_CTSB_chr8_11705230_ENST00000531089_length(transcript)=4184nt_BP=3606nt
CCCCTCCTGCGTGTGGTTCTTGGAGAAAGTTGGAGGTGGTGGTGATTTCAGTCGCCTTGGCCGCCTTGAGCCGGAGCTGAGCGGAGGCAC
TGGGCCGAGCCTGCTTCCCGGGCCTTCCTACCATGCCAGGGCTGCTCCCTGCCTCCGCCACCCTGGCACACCTTCACCCGCGTACCGCCT
CCTCCCCGTCGCTCTGCCTTTTCCAAAACTCACTTGGGCCCTCCGTGCGCAGGGTTCTTTTTTGGTTTTTCTGTAAAAATCAAAACAAAA
AACAGAGACTTTTGAGAGGAGCAGATGCCACCTAAAGTCCCACTGCATTCCCTGCAAAGCGCTCAAATGTGGAAGCCAGTCATTGGCATT
TTTATTTTTTATTGATTGATTGATTTTTTCACCAGTGGCTTTTTGTAACCTCTGTGTTCTGCTGTGTTTCTTGTGTTTAGTCTTCGAGTG
CTTCGACTGACCATGATCCCCTGGGCCCCCTCCCTCCTGGCTGGGAGAAGAGACAGGACAATGGACGGGTGTATTACGTGAACCATAACA
CTCGCACGACCCAGTGGGAGGATCCCCGGACCCAGGGGATGATCCAGGAACCAGCTCTGCCCCCAGGATGGGAGATGAAATACACCAGCG
AGGGGGTGCGATACTTTGTGGACCACAATACCCGCACCACCACCTTTAAGGATCCTCGCCCGGGGTTTGAGTCGGGGACGAAGCAAGGTT
CCCCTGGTGCTTATGACCGCAGTTTTCGGTGGAAGTATCACCAGTTCCGTTTCCTCTGCCATTCAAATGCCCTACCTAGCCACGTGAAGA
TCAGCGTTTCCAGGCAGACGCTTTTCGAAGATTCCTTCCAACAGATCATGAACATGAAACCCTATGACCTGCGCCGCCGGCTCTACATCA
TCATGCGTGGCGAGGAGGGCCTGGACTATGGGGGCATCGCCAGAGAGTGGTTTTTCCTCCTGTCTCATGAGGTGCTCAACCCTATGTATT
GTTTATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCATCAACCCGGACCACCTCACCTACTTTCGCT
TTATAGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCACCCTCCCTTTCTACAAGCGGATGCTCAATA
AGAGACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCTGGATCAAAGAGAACAACCTGGAAGAATGTG
GCCTGGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGCTGAAGGAGGGCGGCGAGAGCATCCGGGTCA
CAGAGGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCGTGGAAGAGCAGACCAAAGCCTTCCTGGATG
GCTTCAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGCTGATGCTGTGCGGCATGCAGGAGATAGACA
TGAGCGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCCAGTGGTTCTGGCAGGTGGTGAAGGAGATGG
ACAACGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCGGGGGATTTGCCGAACTCATCGGTAGCAACG
GACCACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACACCTGCATTGAGGAGACCGAGGGCTTTGGAC
AGGAGTAACCGAGGCCGCCCCTCCCACGCCCCCCAGCGCACATGTAGTCCTGAGTCCTCCCTGCCTGAGAGGCCACTGGCCCCGCAGCCC
TTGGGAGGCCCCCGTGGATGTGGCCCTGTGTGGGACCACACTGTCATCTCGCTGCTGGCAGAAAAGCCTGATCCCAGGAGGCCCTGCAGT
TCCCCCGACCCGCGGATGGCAGTCTGGAATAAAGCCCCCTAGTTGCCTTTGGCCCCACCTTTGCAAAGTTCCAGAGGGCTGACCCTCTCT
GCAAAACTCTCCCCTGTCCTCTAGACCCCACCCTGGGTGTATGTGAGTGTGCAAGGGAAGGTGTTGCATCCCCAGGGGCTGCCGCAGAGG
CCGGAGACCTCCTGGACTAGTTCGGCGAGGAGACTGGCCACTGGGGGTGGCTGTTCGGGACTGAGAGCGCCAAGGGTCTTTGCCAGCAAA
GGAGGTTCTGCCTGTAATTGAGCCTCTCTGATGATGGAGATGAAGTGAAGGTCTGAGGGAGCGGGCCCTGGGGCGAGGCCATCTCTGCCT
GCCTCCCTAGCAGGCGCCAGCGGTGGAGGCTGAGTCGCAGGACACATGCCGGCCAGTTAATTCATTCTCAGCCAATGAAGGTTTGTCTAA
GCTGCCTGGGTATCCACGGGACAAAAACAGCAAACTCCCTCAGACTTTGTCCATGTATAAACTTGAAGTGGTTGTGTTGTAGGGTTGCAG
GTTTTTTGTTACGCTGCTGTCACTTTCTGTCCAGGAGCTGGCACCCCAGGTGTTCTGAGACCTTGAGGGACCCAGACCTTTGGGTCCAAG
AGTTTCCCAAACAGCCACGCCTCTCAGGAACCCACCTGGCGGTTCCGTGAGCTCAGGCAGGCCTGACCCGGCGGCACAGCCTGGCAGGGA
CCTCGTCCCCAAGCCTGGCAGAATGAGAGGGGTTGAGGTCCCGAGCGCCACTCCTAGCCTTGCCGCCTTCAATAGAGAAGAAATCCCTTT
GCTAGATAGGGTCCCCCAGGCAGTCCCCAGTGGCGGGACACAGGGGTCCGGCTGTGGAGCTCCCCTGCCAGCCCCTGGAGCTCCAGGAGG
GCCTGTTGGTCCCCTGTTCAGAATGGAGTGCAGCCCGCCAGCGGAAAGTGTTCATTCTGCATAGGTGTGAGGCTTTATCTGCACACAGGA
CATGAAAACCAGCAGAAAGGCCCTGAGCTGCTGCATAGCCCCATCTGATTTCTGCAGTTCCCGCCAGCCTCCAACACGGGGACTCTGCCG
TAACTGGAATCTTCATAGGTCATATTGAAATCTTCAAGGTGACCATGCCCCACCGGGGTGCTGGGGCAGTAGTCATGGCAGACTCCCGGC
CTGGGCCCCCAGGATTCTAGGACCCCCAGGCAGCCCCTTGGACTGGTCCCGGGTGCCTTCCAAGCACAGTCTCCATGCTCCCAGATTCTC
GACCTTCCCCCGGCCCGGGAGGTGCAGCCTGCGTCTGCCTCTGTCGTGTGTGCTGATTTGAGTGGCTTAGCTTGCCACAGCGCAGCCTCT
TCTGTCCCTTTCAGTCATTTGCTGTACTTCCCTGTGGCACGTTACCATGGAAGCCGCTCCAGGGTGGGTCAGGGTGCAAGCTGCTGGTGA
GGTTTGGAAGCATCAGGCTCACGGGTGTTCATGTGTGTTCGTGCGTGTGTGTGCGTACGTGTATATAACTGAAGTGTCTGTACGGAATGC
CCTTTGCTAGCCATGGGCTGGTCACCAGATTGTTTTGTAATGCCCGCCCCTTGCCTCGATATTGCCAGTTTCTTGTGCAATAAACAATCA
GCAGCTAGAATCACGTCCTGGAACTGCATGTTCTTGCGACTCTTGGGACTTCATCTTAACTTCTCGCTGCCCCAGCCATGTTTTCAACCA
TGGCATCCCTCCCCCAATTAGTTCCCTGTCATCCTCGTCAACCTTCTCTGTAAGTGCCTGGTAAGCTTCTTTAAAATACTCAGAGGACAG
GATCACTGTGGAATCGAATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTAATCTGCCGTGGGCCTGTCG
TGCCAGTCCTGGGGGCGAGATCGGGGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATCCGCATCCTGGGCTGGGGA
GTGGAGAATGGCACACCCTACTGGCTGGTTGCCAACTCCTGGAACACTGACTGGGGTGACAATGGATACAATTCCTACAGCGTCTCCAAT
AGCGAGAAGGACATCATGGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACTTCCTGCTCTACAAGTCA

>99524_99524_10_WWP2-CTSB_WWP2_chr16_69973809_ENST00000568684_CTSB_chr8_11705230_ENST00000531089_length(amino acids)=445AA_BP=
MGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDR
SFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAG
KNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFI
QDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for WWP2-CTSB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WWP2-CTSB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WWP2-CTSB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource