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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WWP2-FAM214A (FusionGDB2 ID:99527)

Fusion Gene Summary for WWP2-FAM214A

check button Fusion gene summary
Fusion gene informationFusion gene name: WWP2-FAM214A
Fusion gene ID: 99527
HgeneTgene
Gene symbol

WWP2

FAM214A

Gene ID

11060

56204

Gene nameWW domain containing E3 ubiquitin protein ligase 2family with sequence similarity 214 member A
SynonymsAIP2|WWp2-likeKIAA1370
Cytomap

16q22.1

15q21.2-q21.3

Type of geneprotein-codingprotein-coding
DescriptionNEDD4-like E3 ubiquitin-protein ligase WWP2HECT-type E3 ubiquitin transferase WWP2atrophin-1 interacting protein 2protein FAM214A
Modification date2020032720200313
UniProtAcc.

Q32MH5

Ensembl transtripts involved in fusion geneENST00000544162, ENST00000356003, 
ENST00000359154, ENST00000448661, 
ENST00000569174, ENST00000542271, 
ENST00000568684, 		ENST00000261844, 
ENST00000546305, ENST00000562351, 
Fusion gene scores* DoF score18 X 16 X 11=31688 X 7 X 4=224
# samples 238
** MAII scorelog2(23/3168*10)=-3.78386656913523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WWP2 [Title/Abstract] AND FAM214A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWWP2(69833198)-FAM214A(52906054), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWP2

GO:0016567

protein ubiquitination

18776082|26280536

HgeneWWP2

GO:0032410

negative regulation of transporter activity

18776082

HgeneWWP2

GO:0034765

regulation of ion transmembrane transport

17289006

HgeneWWP2

GO:0042391

regulation of membrane potential

17289006

HgeneWWP2

GO:0051865

protein autoubiquitination

24105792

HgeneWWP2

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006


check buttonFusion gene breakpoints across WWP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM214A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4QI-01AWWP2chr16

69833198

+FAM214Achr15

52906054

-


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Fusion Gene ORF analysis for WWP2-FAM214A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000544162ENST00000261844WWP2chr16

69833198

+FAM214Achr15

52906054

-
3UTR-intronENST00000544162ENST00000546305WWP2chr16

69833198

+FAM214Achr15

52906054

-
3UTR-intronENST00000544162ENST00000562351WWP2chr16

69833198

+FAM214Achr15

52906054

-
5CDS-intronENST00000356003ENST00000546305WWP2chr16

69833198

+FAM214Achr15

52906054

-
5CDS-intronENST00000356003ENST00000562351WWP2chr16

69833198

+FAM214Achr15

52906054

-
5CDS-intronENST00000359154ENST00000546305WWP2chr16

69833198

+FAM214Achr15

52906054

-
5CDS-intronENST00000359154ENST00000562351WWP2chr16

69833198

+FAM214Achr15

52906054

-
5CDS-intronENST00000448661ENST00000546305WWP2chr16

69833198

+FAM214Achr15

52906054

-
5CDS-intronENST00000448661ENST00000562351WWP2chr16

69833198

+FAM214Achr15

52906054

-
5CDS-intronENST00000569174ENST00000546305WWP2chr16

69833198

+FAM214Achr15

52906054

-
5CDS-intronENST00000569174ENST00000562351WWP2chr16

69833198

+FAM214Achr15

52906054

-
In-frameENST00000356003ENST00000261844WWP2chr16

69833198

+FAM214Achr15

52906054

-
In-frameENST00000359154ENST00000261844WWP2chr16

69833198

+FAM214Achr15

52906054

-
In-frameENST00000448661ENST00000261844WWP2chr16

69833198

+FAM214Achr15

52906054

-
In-frameENST00000569174ENST00000261844WWP2chr16

69833198

+FAM214Achr15

52906054

-
intron-3CDSENST00000542271ENST00000261844WWP2chr16

69833198

+FAM214Achr15

52906054

-
intron-3CDSENST00000568684ENST00000261844WWP2chr16

69833198

+FAM214Achr15

52906054

-
intron-intronENST00000542271ENST00000546305WWP2chr16

69833198

+FAM214Achr15

52906054

-
intron-intronENST00000542271ENST00000562351WWP2chr16

69833198

+FAM214Achr15

52906054

-
intron-intronENST00000568684ENST00000546305WWP2chr16

69833198

+FAM214Achr15

52906054

-
intron-intronENST00000568684ENST00000562351WWP2chr16

69833198

+FAM214Achr15

52906054

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359154WWP2chr1669833198+ENST00000261844FAM214Achr1552906054-44894417136551194
ENST00000448661WWP2chr1669833198+ENST00000261844FAM214Achr1552906054-44664187836321184
ENST00000569174WWP2chr1669833198+ENST00000261844FAM214Achr1552906054-44584107036241184
ENST00000356003WWP2chr1669833198+ENST00000261844FAM214Achr1552906054-44143662635801184

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359154ENST00000261844WWP2chr1669833198+FAM214Achr1552906054-0.0002215520.99977845
ENST00000448661ENST00000261844WWP2chr1669833198+FAM214Achr1552906054-0.0002162320.9997838
ENST00000569174ENST00000261844WWP2chr1669833198+FAM214Achr1552906054-0.0002123890.9997876
ENST00000356003ENST00000261844WWP2chr1669833198+FAM214Achr1552906054-0.0001991070.99980086

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Fusion Genomic Features for WWP2-FAM214A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WWP2-FAM214A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:69833198/chr15:52906054)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAM214A

Q32MH5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWP2chr16:69833198chr15:52906054ENST00000356003+3231_117113871.0DomainC2
HgeneWWP2chr16:69833198chr15:52906054ENST00000356003+323300_333113871.0DomainWW 1
HgeneWWP2chr16:69833198chr15:52906054ENST00000356003+323330_363113871.0DomainWW 2
HgeneWWP2chr16:69833198chr15:52906054ENST00000356003+323405_437113871.0DomainWW 3
HgeneWWP2chr16:69833198chr15:52906054ENST00000356003+323444_477113871.0DomainWW 4
HgeneWWP2chr16:69833198chr15:52906054ENST00000356003+323536_870113871.0DomainHECT
HgeneWWP2chr16:69833198chr15:52906054ENST00000359154+4241_117113871.0DomainC2
HgeneWWP2chr16:69833198chr15:52906054ENST00000359154+424300_333113871.0DomainWW 1
HgeneWWP2chr16:69833198chr15:52906054ENST00000359154+424330_363113871.0DomainWW 2
HgeneWWP2chr16:69833198chr15:52906054ENST00000359154+424405_437113871.0DomainWW 3
HgeneWWP2chr16:69833198chr15:52906054ENST00000359154+424444_477113871.0DomainWW 4
HgeneWWP2chr16:69833198chr15:52906054ENST00000359154+424536_870113871.0DomainHECT
HgeneWWP2chr16:69833198chr15:52906054ENST00000448661+4241_117113871.0DomainC2
HgeneWWP2chr16:69833198chr15:52906054ENST00000448661+424300_333113871.0DomainWW 1
HgeneWWP2chr16:69833198chr15:52906054ENST00000448661+424330_363113871.0DomainWW 2
HgeneWWP2chr16:69833198chr15:52906054ENST00000448661+424405_437113871.0DomainWW 3
HgeneWWP2chr16:69833198chr15:52906054ENST00000448661+424444_477113871.0DomainWW 4
HgeneWWP2chr16:69833198chr15:52906054ENST00000448661+424536_870113871.0DomainHECT
HgeneWWP2chr16:69833198chr15:52906054ENST00000542271+1211_1170755.0DomainC2
HgeneWWP2chr16:69833198chr15:52906054ENST00000542271+121300_3330755.0DomainWW 1
HgeneWWP2chr16:69833198chr15:52906054ENST00000542271+121330_3630755.0DomainWW 2
HgeneWWP2chr16:69833198chr15:52906054ENST00000542271+121405_4370755.0DomainWW 3
HgeneWWP2chr16:69833198chr15:52906054ENST00000542271+121444_4770755.0DomainWW 4
HgeneWWP2chr16:69833198chr15:52906054ENST00000542271+121536_8700755.0DomainHECT
HgeneWWP2chr16:69833198chr15:52906054ENST00000568684+1141_1170432.0DomainC2
HgeneWWP2chr16:69833198chr15:52906054ENST00000568684+114300_3330432.0DomainWW 1
HgeneWWP2chr16:69833198chr15:52906054ENST00000568684+114330_3630432.0DomainWW 2
HgeneWWP2chr16:69833198chr15:52906054ENST00000568684+114405_4370432.0DomainWW 3
HgeneWWP2chr16:69833198chr15:52906054ENST00000568684+114444_4770432.0DomainWW 4
HgeneWWP2chr16:69833198chr15:52906054ENST00000568684+114536_8700432.0DomainHECT
HgeneWWP2chr16:69833198chr15:52906054ENST00000569174+491_117113336.0DomainC2
HgeneWWP2chr16:69833198chr15:52906054ENST00000569174+49300_333113336.0DomainWW 1
HgeneWWP2chr16:69833198chr15:52906054ENST00000569174+49330_363113336.0DomainWW 2
HgeneWWP2chr16:69833198chr15:52906054ENST00000569174+49405_437113336.0DomainWW 3
HgeneWWP2chr16:69833198chr15:52906054ENST00000569174+49444_477113336.0DomainWW 4
HgeneWWP2chr16:69833198chr15:52906054ENST00000569174+49536_870113336.0DomainHECT


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Fusion Gene Sequence for WWP2-FAM214A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99527_99527_1_WWP2-FAM214A_WWP2_chr16_69833198_ENST00000356003_FAM214A_chr15_52906054_ENST00000261844_length(transcript)=4414nt_BP=366nt
TTGTCTTACAGCTTCACGGTGATGATATGGCATCTGCCAGCTCTAGCCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTT
TGAAAGTGGTGTCCGCAAAGCCCAAGGTGCATAATCGTCAACCTCGAATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTG
AGACCAAGAAGACTGGGAAGCGCATTGGGAGCTCTGAGCTTCTCTGGAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAG
ATTTAAAGGTCTGGAGCTGCCATACCTTGAGAAATGAACTGCTAGGCACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGG
GCAAAAATACTCTGGATGAATATTTTGAATATGATGCAGAGGAGTTCTTGGTCTCTTTGGCCTTGCTGATAACAGAAGGACGAACACCTG
AATGTTCTGTAAAAGGTCGAACAGAAAGCTTTCATTGCCCTCCAGCACAGTCTTGTTACCCAGTAACTACCAAACATGAATGTAGTGACA
AGCTGGCCCAGTGCCGCCAAGCCAGACGAACTAGGTCTGAGGTCACATTGTTGTGGAAGAATAACCTTCCAATCATGGTGGAAATGATGC
TACTACCAGACTGCTGCTACAGCGATGATGGGCCCACCACAGAGGGAATTGATCTAAATGATCCTGCGATTAAGCAAGATGCATTATTAT
TAGAAAGATGGATCTTGGAGCCAGTTCCTCGACAGAATGGTGACCGATTTATTGAAGAGAAGACGCTTCTGTTGGCTGTCCGCTCATTTG
TGTTTTTTTCTCAGTTAAGTGCATGGCTGAGTGTTTCTCATGGTGCTATTCCACGAAATATTCTCTACAGAATCAGTGCTGCTGATGTAG
ACCTACAGTGGAATTTTTCACAGACTCCAATTGAGCATGTGTTTCCTGTTCCCAATGTTTCTCACAATGTTGCCTTGAAAGTCAGTGTTC
AGTCCTTGCCCAGACAATCTAATTATCCAGTTTTGACGTGCAGTATTCACACTAATATTGGCCTTTATGAGAAAAGAATTCAACAACATA
AACTTAAAACTCATCAGCACCATAACCCAAATGAAGCAGAACAATGTGGTACAAACAGTTCACAGCGTCTGTGTAGCAAACAAACTTGGA
CCATGGCACCTGAAAGTGTGTTACATGCAAAAAGTGGCCCAAGTCCAGAATATACTGCAGCTGTCAAAAATATCAAACTATATCCAGGCA
CTGGCAGTAAATCTGACCATGGGACATCTCAAGCCAATATTCTAGGCTTTAGTGGTATAGGTGATATAAAATCACAAGAAACATCAGTGA
GAACTTTAAAATCATTTTCAATGGTTGATTCCAGTATCTCTAACCGCCAGAGTTTCTGGCAGTCAGCTGGTGAGACTAACCCTTTAATAG
GCTCTTTAATTCAGGAGCGGCAAGAAATCATTGCAAGAATTGCCCAACATTTGATTCATTGTGATCCAAGCACTTCACATGTTTCTGGAC
GTCCATTTAATACTCAAGAGTCTAGTTCACTCCATTCAAAACTTTTCCGGGTTTCACAAGAAAATGAGAACGTGGGAAAAGGTAAAGAAG
CTTTCTCCATGACTTTTGGTAGTCCAGAGTTTAGTTCCCCAGAAGACACCAATGAGGGGAAAATTCGACTAAAACCAGAAACTCCTCGAA
GTGAAACTTGTATTTCTAATGACTTTTATTCTCATATGCCTGTTGGAGAGACTAATCCTTTGATAGGCTCTTTACTCCAGGAGCGGCAAG
ATGTTATTGCAAGGATTGCTCAACACTTGGAGCACATTGATCCAACAGCATCACATATCCCCCGGCAGTCATTCAACATGCATGACTCCA
GTTCGGTTGCATCTAAAGTGTTTAGGAGTTCATATGAAGACAAAAATTTGTTGAAGAAAAATAAGGATGAGTCCTCAGTTTCCATTTCTC
ACACAAAATGTTCCTTGTTAGGAGACATCAGTGATGGGAAAAACTTAGTACCTAATAAATGTTTTACTTCTTTTAAAAATAATAGTAAAG
AAAAGTGTTCTTTGAAACATCAAACAAGAAATCAGTGTCAGAACAATCCTAGTGAAATCATCCAAAGTACGTATCAGGAGACACAGAACA
AAAGTTCTAGTTTATCAACTTCCTCAATTTTGTCTCAGCACAAAGAAAATAACTTAGATTTGACAAGCAGATTCAAGGAGCAAGAAATGA
GCAATGGAATTGATAAACAGTATTCAAATTGCACCACTATTGACAAACAGATTTGTACAAATAAGTATAAGGAAAAAATAATAAATGAGA
ACTATAATCCAAAATTCTTTGGCAATCTTCAGTCTGATGATTCCAAAAAAAATGACTCAAAAATAAAAGTTACTGTGTTGGAAATGTCTG
AATATTTGAACAAATATGAAAGCATGTCCTCAAATAAAGACTCAAAAAGGCCTAAGACATGTGAGCAAAATACTCAACTTAATAGCATAG
AGAATTATCTCAATAAAGATAATGAAGGTTTCAAATGTAAAAAGTCAGACCAATTAAAAAATGAACAAGATAAGCAAGAAGATCCAACTA
ATGAAAAATCCCAAAACTATTCTCAGAGAAGAAGTATAAAAGACTGTTTGTCTACATGTGAGCAACCAAAAAATACAGAGGTATTGAGGA
CTACACTGAAACATTCAAATGTGTGGCGAAAACATAATTTTCATTCCTTGGATGGAACTTCAACCAGAGCCTTTCATCCTCAAACTGGAT
TGCCTCTTCTTTCAAGCCCTGTTCCTCAAAGAAAAACACAATCAGGTTGCTTTGATCTGGATTCTTCATTACTACATCTGAAAAGCTTCT
CATCTAGAAGTCCTCGACCATGTTTAAACATTGAAGATGATCCAGATATTCATGAAAAACCATTTTTGAGTTCTAGTGCTCCACCTATAA
CAAGTCTTAGTCTCCTAGGAAATTTTGAGGAATCTGTCTTGAACTATCGTTTCGATCCTCTCGGCATTGTTGATGGTTTTACTGCCGAGG
TAGGGGCAAGTGGTGCTTTCTGCCCCACACATTTGACTCTTCCAGTTGAAGTGTCATTCTACAGTGTTTCAGATGACAATGCTCCCTCTC
CTTATATGGGTGTGATTACTTTAGAGTCCCTTGGTAAAAGGGGTTATCGAGTACCTCCTTCAGGAACAATACAAGTGACCTTATTTAATC
CTAATAAGACTGTGGTGAAGATGTTTGTTGTGATATATGATTTACGAGATATGCCAGCCAATCATCAGACATTCCTACGACAAAGAACTT
TTTCTGTACCTGTTAAACAAGAAGTGAAGAGAAGTGTTAATAAAGAGAACATCCGACACACAGAAGAACGGTTATTACGCTACCTCATAC
ATCTGAGGTTCCAGAGTTCTAAATCTGGAAAGATCTACCTCCATAGAGACGTACGGCTCCTGTTCTCTAGAAAGTCAATGGAGGTTGATA
GCGGTGCTGCATATGAACTCAAATCTTACACTGAATCACCAACAAACCCTCAGTTTTCACCAAGATGTTGATAAGGAGTGATGATTTAAA
GTATTTACTCAGTACCCAAGTTTGCAAGTAAAAATTAGCATAGAATGGAGTGTACCAAATTAACAATCAGGAGAGTGGATTCTCTCCTGT
TATCCTGGACCAGTTTTTATGAAAGGATTCCTGAAATGAAATCCATATATTCCATGTAGACTGGAAAAACTCATGTCCTAATCCTTTTTG
TACTGTTGAAACCACTTCATTGGACATGTTGCAATAGCAAAACCCCCAGTTAGATTAGTGTTTACACATTTTCTCAGTTATTTAATATTT
AATGTTTTCCTTAATACTCAAGTGATGTTTGTCTCTAGTGTTCTAATGTAGCACAAATCCTATGTAAAATCATACTATGTATTTTTGACA
TTAATGTTGAAATCAAATATATGCACAAGTCTTTAATTTTGTGTAATGTGTTAAGTGCTGTTCATTTAAGTTATTGAAAATGAGAATAAA
ATGTTGAGCTTCTTTAAAAGTAACACACTATGCAAGCATGTGTACTTTTTATATCTCTCATGTTTAGTTTTTATAACACCATATCCAGGT
TGCTATCTCACATAGTAGTCCTTTAACATATTGTATTAGCAGTGCAATGTGGACTAAGCTGCTTCACTTTCCCTTTGCAAGTTCAGATCA
TCATGCCCATTCATAGCCAGGATTCCTTATCCCCAAAACAGTTCTATTTTTCCTTAATCACTACTATAGAGTCTTTACATTAAATTACTG
TCGTATGCTAGATAATTTTCTCAAATTGTTAAAAGAATATGTACTTTGGAAACAAATTAGTATTTATATTGTAAATATATTCAAAAAAAA

>99527_99527_1_WWP2-FAM214A_WWP2_chr16_69833198_ENST00000356003_FAM214A_chr15_52906054_ENST00000261844_length(amino acids)=1184AA_BP=114
MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSHLDLKVWSCHT
LRNELLGTASVNLSNVLKNNGGKNTLDEYFEYDAEEFLVSLALLITEGRTPECSVKGRTESFHCPPAQSCYPVTTKHECSDKLAQCRQAR
RTRSEVTLLWKNNLPIMVEMMLLPDCCYSDDGPTTEGIDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKTLLLAVRSFVFFSQLSAW
LSVSHGAIPRNILYRISAADVDLQWNFSQTPIEHVFPVPNVSHNVALKVSVQSLPRQSNYPVLTCSIHTNIGLYEKRIQQHKLKTHQHHN
PNEAEQCGTNSSQRLCSKQTWTMAPESVLHAKSGPSPEYTAAVKNIKLYPGTGSKSDHGTSQANILGFSGIGDIKSQETSVRTLKSFSMV
DSSISNRQSFWQSAGETNPLIGSLIQERQEIIARIAQHLIHCDPSTSHVSGRPFNTQESSSLHSKLFRVSQENENVGKGKEAFSMTFGSP
EFSSPEDTNEGKIRLKPETPRSETCISNDFYSHMPVGETNPLIGSLLQERQDVIARIAQHLEHIDPTASHIPRQSFNMHDSSSVASKVFR
SSYEDKNLLKKNKDESSVSISHTKCSLLGDISDGKNLVPNKCFTSFKNNSKEKCSLKHQTRNQCQNNPSEIIQSTYQETQNKSSSLSTSS
ILSQHKENNLDLTSRFKEQEMSNGIDKQYSNCTTIDKQICTNKYKEKIINENYNPKFFGNLQSDDSKKNDSKIKVTVLEMSEYLNKYESM
SSNKDSKRPKTCEQNTQLNSIENYLNKDNEGFKCKKSDQLKNEQDKQEDPTNEKSQNYSQRRSIKDCLSTCEQPKNTEVLRTTLKHSNVW
RKHNFHSLDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDSSLLHLKSFSSRSPRPCLNIEDDPDIHEKPFLSSSAPPITSLSLLGNF
EESVLNYRFDPLGIVDGFTAEVGASGAFCPTHLTLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNKTVVKMF
VVIYDLRDMPANHQTFLRQRTFSVPVKQEVKRSVNKENIRHTEERLLRYLIHLRFQSSKSGKIYLHRDVRLLFSRKSMEVDSGAAYELKS

--------------------------------------------------------------
>99527_99527_2_WWP2-FAM214A_WWP2_chr16_69833198_ENST00000359154_FAM214A_chr15_52906054_ENST00000261844_length(transcript)=4489nt_BP=441nt
GCGCGGTCACGTGACCCGGCCCGAGTGCGGGCGGTGGAAGGCGGAAGTAGGAGAGGAGTTCGGCGCCGCTTCTGTGGCCACGGCAGCTTC
ACGGTGATGATATGGCATCTGCCAGCTCTAGCCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTTTGAAAGTGGTGTCCG
CAAAGCCCAAGGTGCATAATCGTCAACCTCGAATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTGAGACCAAGAAGACTG
GGAAGCGCATTGGGAGCTCTGAGCTTCTCTGGAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAGATTTAAAGGTCTGGA
GCTGCCATACCTTGAGAAATGAACTGCTAGGCACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGGGCAAAAATACTCTGG
ATGAATATTTTGAATATGATGCAGAGGAGTTCTTGGTCTCTTTGGCCTTGCTGATAACAGAAGGACGAACACCTGAATGTTCTGTAAAAG
GTCGAACAGAAAGCTTTCATTGCCCTCCAGCACAGTCTTGTTACCCAGTAACTACCAAACATGAATGTAGTGACAAGCTGGCCCAGTGCC
GCCAAGCCAGACGAACTAGGTCTGAGGTCACATTGTTGTGGAAGAATAACCTTCCAATCATGGTGGAAATGATGCTACTACCAGACTGCT
GCTACAGCGATGATGGGCCCACCACAGAGGGAATTGATCTAAATGATCCTGCGATTAAGCAAGATGCATTATTATTAGAAAGATGGATCT
TGGAGCCAGTTCCTCGACAGAATGGTGACCGATTTATTGAAGAGAAGACGCTTCTGTTGGCTGTCCGCTCATTTGTGTTTTTTTCTCAGT
TAAGTGCATGGCTGAGTGTTTCTCATGGTGCTATTCCACGAAATATTCTCTACAGAATCAGTGCTGCTGATGTAGACCTACAGTGGAATT
TTTCACAGACTCCAATTGAGCATGTGTTTCCTGTTCCCAATGTTTCTCACAATGTTGCCTTGAAAGTCAGTGTTCAGTCCTTGCCCAGAC
AATCTAATTATCCAGTTTTGACGTGCAGTATTCACACTAATATTGGCCTTTATGAGAAAAGAATTCAACAACATAAACTTAAAACTCATC
AGCACCATAACCCAAATGAAGCAGAACAATGTGGTACAAACAGTTCACAGCGTCTGTGTAGCAAACAAACTTGGACCATGGCACCTGAAA
GTGTGTTACATGCAAAAAGTGGCCCAAGTCCAGAATATACTGCAGCTGTCAAAAATATCAAACTATATCCAGGCACTGGCAGTAAATCTG
ACCATGGGACATCTCAAGCCAATATTCTAGGCTTTAGTGGTATAGGTGATATAAAATCACAAGAAACATCAGTGAGAACTTTAAAATCAT
TTTCAATGGTTGATTCCAGTATCTCTAACCGCCAGAGTTTCTGGCAGTCAGCTGGTGAGACTAACCCTTTAATAGGCTCTTTAATTCAGG
AGCGGCAAGAAATCATTGCAAGAATTGCCCAACATTTGATTCATTGTGATCCAAGCACTTCACATGTTTCTGGACGTCCATTTAATACTC
AAGAGTCTAGTTCACTCCATTCAAAACTTTTCCGGGTTTCACAAGAAAATGAGAACGTGGGAAAAGGTAAAGAAGCTTTCTCCATGACTT
TTGGTAGTCCAGAGTTTAGTTCCCCAGAAGACACCAATGAGGGGAAAATTCGACTAAAACCAGAAACTCCTCGAAGTGAAACTTGTATTT
CTAATGACTTTTATTCTCATATGCCTGTTGGAGAGACTAATCCTTTGATAGGCTCTTTACTCCAGGAGCGGCAAGATGTTATTGCAAGGA
TTGCTCAACACTTGGAGCACATTGATCCAACAGCATCACATATCCCCCGGCAGTCATTCAACATGCATGACTCCAGTTCGGTTGCATCTA
AAGTGTTTAGGAGTTCATATGAAGACAAAAATTTGTTGAAGAAAAATAAGGATGAGTCCTCAGTTTCCATTTCTCACACAAAATGTTCCT
TGTTAGGAGACATCAGTGATGGGAAAAACTTAGTACCTAATAAATGTTTTACTTCTTTTAAAAATAATAGTAAAGAAAAGTGTTCTTTGA
AACATCAAACAAGAAATCAGTGTCAGAACAATCCTAGTGAAATCATCCAAAGTACGTATCAGGAGACACAGAACAAAAGTTCTAGTTTAT
CAACTTCCTCAATTTTGTCTCAGCACAAAGAAAATAACTTAGATTTGACAAGCAGATTCAAGGAGCAAGAAATGAGCAATGGAATTGATA
AACAGTATTCAAATTGCACCACTATTGACAAACAGATTTGTACAAATAAGTATAAGGAAAAAATAATAAATGAGAACTATAATCCAAAAT
TCTTTGGCAATCTTCAGTCTGATGATTCCAAAAAAAATGACTCAAAAATAAAAGTTACTGTGTTGGAAATGTCTGAATATTTGAACAAAT
ATGAAAGCATGTCCTCAAATAAAGACTCAAAAAGGCCTAAGACATGTGAGCAAAATACTCAACTTAATAGCATAGAGAATTATCTCAATA
AAGATAATGAAGGTTTCAAATGTAAAAAGTCAGACCAATTAAAAAATGAACAAGATAAGCAAGAAGATCCAACTAATGAAAAATCCCAAA
ACTATTCTCAGAGAAGAAGTATAAAAGACTGTTTGTCTACATGTGAGCAACCAAAAAATACAGAGGTATTGAGGACTACACTGAAACATT
CAAATGTGTGGCGAAAACATAATTTTCATTCCTTGGATGGAACTTCAACCAGAGCCTTTCATCCTCAAACTGGATTGCCTCTTCTTTCAA
GCCCTGTTCCTCAAAGAAAAACACAATCAGGTTGCTTTGATCTGGATTCTTCATTACTACATCTGAAAAGCTTCTCATCTAGAAGTCCTC
GACCATGTTTAAACATTGAAGATGATCCAGATATTCATGAAAAACCATTTTTGAGTTCTAGTGCTCCACCTATAACAAGTCTTAGTCTCC
TAGGAAATTTTGAGGAATCTGTCTTGAACTATCGTTTCGATCCTCTCGGCATTGTTGATGGTTTTACTGCCGAGGTAGGGGCAAGTGGTG
CTTTCTGCCCCACACATTTGACTCTTCCAGTTGAAGTGTCATTCTACAGTGTTTCAGATGACAATGCTCCCTCTCCTTATATGGGTGTGA
TTACTTTAGAGTCCCTTGGTAAAAGGGGTTATCGAGTACCTCCTTCAGGAACAATACAAGTGACCTTATTTAATCCTAATAAGACTGTGG
TGAAGATGTTTGTTGTGATATATGATTTACGAGATATGCCAGCCAATCATCAGACATTCCTACGACAAAGAACTTTTTCTGTACCTGTTA
AACAAGAAGTGAAGAGAAGTGTTAATAAAGAGAACATCCGACACACAGAAGAACGGTTATTACGCTACCTCATACATCTGAGGTTCCAGA
GTTCTAAATCTGGAAAGATCTACCTCCATAGAGACGTACGGCTCCTGTTCTCTAGAAAGTCAATGGAGGTTGATAGCGGTGCTGCATATG
AACTCAAATCTTACACTGAATCACCAACAAACCCTCAGTTTTCACCAAGATGTTGATAAGGAGTGATGATTTAAAGTATTTACTCAGTAC
CCAAGTTTGCAAGTAAAAATTAGCATAGAATGGAGTGTACCAAATTAACAATCAGGAGAGTGGATTCTCTCCTGTTATCCTGGACCAGTT
TTTATGAAAGGATTCCTGAAATGAAATCCATATATTCCATGTAGACTGGAAAAACTCATGTCCTAATCCTTTTTGTACTGTTGAAACCAC
TTCATTGGACATGTTGCAATAGCAAAACCCCCAGTTAGATTAGTGTTTACACATTTTCTCAGTTATTTAATATTTAATGTTTTCCTTAAT
ACTCAAGTGATGTTTGTCTCTAGTGTTCTAATGTAGCACAAATCCTATGTAAAATCATACTATGTATTTTTGACATTAATGTTGAAATCA
AATATATGCACAAGTCTTTAATTTTGTGTAATGTGTTAAGTGCTGTTCATTTAAGTTATTGAAAATGAGAATAAAATGTTGAGCTTCTTT
AAAAGTAACACACTATGCAAGCATGTGTACTTTTTATATCTCTCATGTTTAGTTTTTATAACACCATATCCAGGTTGCTATCTCACATAG
TAGTCCTTTAACATATTGTATTAGCAGTGCAATGTGGACTAAGCTGCTTCACTTTCCCTTTGCAAGTTCAGATCATCATGCCCATTCATA
GCCAGGATTCCTTATCCCCAAAACAGTTCTATTTTTCCTTAATCACTACTATAGAGTCTTTACATTAAATTACTGTCGTATGCTAGATAA

>99527_99527_2_WWP2-FAM214A_WWP2_chr16_69833198_ENST00000359154_FAM214A_chr15_52906054_ENST00000261844_length(amino acids)=1194AA_BP=124
MWPRQLHGDDMASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSH
LDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKNTLDEYFEYDAEEFLVSLALLITEGRTPECSVKGRTESFHCPPAQSCYPVTTKHECS
DKLAQCRQARRTRSEVTLLWKNNLPIMVEMMLLPDCCYSDDGPTTEGIDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKTLLLAVRS
FVFFSQLSAWLSVSHGAIPRNILYRISAADVDLQWNFSQTPIEHVFPVPNVSHNVALKVSVQSLPRQSNYPVLTCSIHTNIGLYEKRIQQ
HKLKTHQHHNPNEAEQCGTNSSQRLCSKQTWTMAPESVLHAKSGPSPEYTAAVKNIKLYPGTGSKSDHGTSQANILGFSGIGDIKSQETS
VRTLKSFSMVDSSISNRQSFWQSAGETNPLIGSLIQERQEIIARIAQHLIHCDPSTSHVSGRPFNTQESSSLHSKLFRVSQENENVGKGK
EAFSMTFGSPEFSSPEDTNEGKIRLKPETPRSETCISNDFYSHMPVGETNPLIGSLLQERQDVIARIAQHLEHIDPTASHIPRQSFNMHD
SSSVASKVFRSSYEDKNLLKKNKDESSVSISHTKCSLLGDISDGKNLVPNKCFTSFKNNSKEKCSLKHQTRNQCQNNPSEIIQSTYQETQ
NKSSSLSTSSILSQHKENNLDLTSRFKEQEMSNGIDKQYSNCTTIDKQICTNKYKEKIINENYNPKFFGNLQSDDSKKNDSKIKVTVLEM
SEYLNKYESMSSNKDSKRPKTCEQNTQLNSIENYLNKDNEGFKCKKSDQLKNEQDKQEDPTNEKSQNYSQRRSIKDCLSTCEQPKNTEVL
RTTLKHSNVWRKHNFHSLDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDSSLLHLKSFSSRSPRPCLNIEDDPDIHEKPFLSSSAPP
ITSLSLLGNFEESVLNYRFDPLGIVDGFTAEVGASGAFCPTHLTLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLF
NPNKTVVKMFVVIYDLRDMPANHQTFLRQRTFSVPVKQEVKRSVNKENIRHTEERLLRYLIHLRFQSSKSGKIYLHRDVRLLFSRKSMEV

--------------------------------------------------------------
>99527_99527_3_WWP2-FAM214A_WWP2_chr16_69833198_ENST00000448661_FAM214A_chr15_52906054_ENST00000261844_length(transcript)=4466nt_BP=418nt
TTCGGCGCCGCTTCTGTGGCCACGGCAGGTAGCGAGCGCTGGCGCGGGGGGCGCGTCTTACAGCTTCACGGTGATGATATGGCATCTGCC
AGCTCTAGCCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTTTGAAAGTGGTGTCCGCAAAGCCCAAGGTGCATAATCGT
CAACCTCGAATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTGAGACCAAGAAGACTGGGAAGCGCATTGGGAGCTCTGAG
CTTCTCTGGAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAGATTTAAAGGTCTGGAGCTGCCATACCTTGAGAAATGAA
CTGCTAGGCACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGGGCAAAAATACTCTGGATGAATATTTTGAATATGATGCA
GAGGAGTTCTTGGTCTCTTTGGCCTTGCTGATAACAGAAGGACGAACACCTGAATGTTCTGTAAAAGGTCGAACAGAAAGCTTTCATTGC
CCTCCAGCACAGTCTTGTTACCCAGTAACTACCAAACATGAATGTAGTGACAAGCTGGCCCAGTGCCGCCAAGCCAGACGAACTAGGTCT
GAGGTCACATTGTTGTGGAAGAATAACCTTCCAATCATGGTGGAAATGATGCTACTACCAGACTGCTGCTACAGCGATGATGGGCCCACC
ACAGAGGGAATTGATCTAAATGATCCTGCGATTAAGCAAGATGCATTATTATTAGAAAGATGGATCTTGGAGCCAGTTCCTCGACAGAAT
GGTGACCGATTTATTGAAGAGAAGACGCTTCTGTTGGCTGTCCGCTCATTTGTGTTTTTTTCTCAGTTAAGTGCATGGCTGAGTGTTTCT
CATGGTGCTATTCCACGAAATATTCTCTACAGAATCAGTGCTGCTGATGTAGACCTACAGTGGAATTTTTCACAGACTCCAATTGAGCAT
GTGTTTCCTGTTCCCAATGTTTCTCACAATGTTGCCTTGAAAGTCAGTGTTCAGTCCTTGCCCAGACAATCTAATTATCCAGTTTTGACG
TGCAGTATTCACACTAATATTGGCCTTTATGAGAAAAGAATTCAACAACATAAACTTAAAACTCATCAGCACCATAACCCAAATGAAGCA
GAACAATGTGGTACAAACAGTTCACAGCGTCTGTGTAGCAAACAAACTTGGACCATGGCACCTGAAAGTGTGTTACATGCAAAAAGTGGC
CCAAGTCCAGAATATACTGCAGCTGTCAAAAATATCAAACTATATCCAGGCACTGGCAGTAAATCTGACCATGGGACATCTCAAGCCAAT
ATTCTAGGCTTTAGTGGTATAGGTGATATAAAATCACAAGAAACATCAGTGAGAACTTTAAAATCATTTTCAATGGTTGATTCCAGTATC
TCTAACCGCCAGAGTTTCTGGCAGTCAGCTGGTGAGACTAACCCTTTAATAGGCTCTTTAATTCAGGAGCGGCAAGAAATCATTGCAAGA
ATTGCCCAACATTTGATTCATTGTGATCCAAGCACTTCACATGTTTCTGGACGTCCATTTAATACTCAAGAGTCTAGTTCACTCCATTCA
AAACTTTTCCGGGTTTCACAAGAAAATGAGAACGTGGGAAAAGGTAAAGAAGCTTTCTCCATGACTTTTGGTAGTCCAGAGTTTAGTTCC
CCAGAAGACACCAATGAGGGGAAAATTCGACTAAAACCAGAAACTCCTCGAAGTGAAACTTGTATTTCTAATGACTTTTATTCTCATATG
CCTGTTGGAGAGACTAATCCTTTGATAGGCTCTTTACTCCAGGAGCGGCAAGATGTTATTGCAAGGATTGCTCAACACTTGGAGCACATT
GATCCAACAGCATCACATATCCCCCGGCAGTCATTCAACATGCATGACTCCAGTTCGGTTGCATCTAAAGTGTTTAGGAGTTCATATGAA
GACAAAAATTTGTTGAAGAAAAATAAGGATGAGTCCTCAGTTTCCATTTCTCACACAAAATGTTCCTTGTTAGGAGACATCAGTGATGGG
AAAAACTTAGTACCTAATAAATGTTTTACTTCTTTTAAAAATAATAGTAAAGAAAAGTGTTCTTTGAAACATCAAACAAGAAATCAGTGT
CAGAACAATCCTAGTGAAATCATCCAAAGTACGTATCAGGAGACACAGAACAAAAGTTCTAGTTTATCAACTTCCTCAATTTTGTCTCAG
CACAAAGAAAATAACTTAGATTTGACAAGCAGATTCAAGGAGCAAGAAATGAGCAATGGAATTGATAAACAGTATTCAAATTGCACCACT
ATTGACAAACAGATTTGTACAAATAAGTATAAGGAAAAAATAATAAATGAGAACTATAATCCAAAATTCTTTGGCAATCTTCAGTCTGAT
GATTCCAAAAAAAATGACTCAAAAATAAAAGTTACTGTGTTGGAAATGTCTGAATATTTGAACAAATATGAAAGCATGTCCTCAAATAAA
GACTCAAAAAGGCCTAAGACATGTGAGCAAAATACTCAACTTAATAGCATAGAGAATTATCTCAATAAAGATAATGAAGGTTTCAAATGT
AAAAAGTCAGACCAATTAAAAAATGAACAAGATAAGCAAGAAGATCCAACTAATGAAAAATCCCAAAACTATTCTCAGAGAAGAAGTATA
AAAGACTGTTTGTCTACATGTGAGCAACCAAAAAATACAGAGGTATTGAGGACTACACTGAAACATTCAAATGTGTGGCGAAAACATAAT
TTTCATTCCTTGGATGGAACTTCAACCAGAGCCTTTCATCCTCAAACTGGATTGCCTCTTCTTTCAAGCCCTGTTCCTCAAAGAAAAACA
CAATCAGGTTGCTTTGATCTGGATTCTTCATTACTACATCTGAAAAGCTTCTCATCTAGAAGTCCTCGACCATGTTTAAACATTGAAGAT
GATCCAGATATTCATGAAAAACCATTTTTGAGTTCTAGTGCTCCACCTATAACAAGTCTTAGTCTCCTAGGAAATTTTGAGGAATCTGTC
TTGAACTATCGTTTCGATCCTCTCGGCATTGTTGATGGTTTTACTGCCGAGGTAGGGGCAAGTGGTGCTTTCTGCCCCACACATTTGACT
CTTCCAGTTGAAGTGTCATTCTACAGTGTTTCAGATGACAATGCTCCCTCTCCTTATATGGGTGTGATTACTTTAGAGTCCCTTGGTAAA
AGGGGTTATCGAGTACCTCCTTCAGGAACAATACAAGTGACCTTATTTAATCCTAATAAGACTGTGGTGAAGATGTTTGTTGTGATATAT
GATTTACGAGATATGCCAGCCAATCATCAGACATTCCTACGACAAAGAACTTTTTCTGTACCTGTTAAACAAGAAGTGAAGAGAAGTGTT
AATAAAGAGAACATCCGACACACAGAAGAACGGTTATTACGCTACCTCATACATCTGAGGTTCCAGAGTTCTAAATCTGGAAAGATCTAC
CTCCATAGAGACGTACGGCTCCTGTTCTCTAGAAAGTCAATGGAGGTTGATAGCGGTGCTGCATATGAACTCAAATCTTACACTGAATCA
CCAACAAACCCTCAGTTTTCACCAAGATGTTGATAAGGAGTGATGATTTAAAGTATTTACTCAGTACCCAAGTTTGCAAGTAAAAATTAG
CATAGAATGGAGTGTACCAAATTAACAATCAGGAGAGTGGATTCTCTCCTGTTATCCTGGACCAGTTTTTATGAAAGGATTCCTGAAATG
AAATCCATATATTCCATGTAGACTGGAAAAACTCATGTCCTAATCCTTTTTGTACTGTTGAAACCACTTCATTGGACATGTTGCAATAGC
AAAACCCCCAGTTAGATTAGTGTTTACACATTTTCTCAGTTATTTAATATTTAATGTTTTCCTTAATACTCAAGTGATGTTTGTCTCTAG
TGTTCTAATGTAGCACAAATCCTATGTAAAATCATACTATGTATTTTTGACATTAATGTTGAAATCAAATATATGCACAAGTCTTTAATT
TTGTGTAATGTGTTAAGTGCTGTTCATTTAAGTTATTGAAAATGAGAATAAAATGTTGAGCTTCTTTAAAAGTAACACACTATGCAAGCA
TGTGTACTTTTTATATCTCTCATGTTTAGTTTTTATAACACCATATCCAGGTTGCTATCTCACATAGTAGTCCTTTAACATATTGTATTA
GCAGTGCAATGTGGACTAAGCTGCTTCACTTTCCCTTTGCAAGTTCAGATCATCATGCCCATTCATAGCCAGGATTCCTTATCCCCAAAA
CAGTTCTATTTTTCCTTAATCACTACTATAGAGTCTTTACATTAAATTACTGTCGTATGCTAGATAATTTTCTCAAATTGTTAAAAGAAT

>99527_99527_3_WWP2-FAM214A_WWP2_chr16_69833198_ENST00000448661_FAM214A_chr15_52906054_ENST00000261844_length(amino acids)=1184AA_BP=114
MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSHLDLKVWSCHT
LRNELLGTASVNLSNVLKNNGGKNTLDEYFEYDAEEFLVSLALLITEGRTPECSVKGRTESFHCPPAQSCYPVTTKHECSDKLAQCRQAR
RTRSEVTLLWKNNLPIMVEMMLLPDCCYSDDGPTTEGIDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKTLLLAVRSFVFFSQLSAW
LSVSHGAIPRNILYRISAADVDLQWNFSQTPIEHVFPVPNVSHNVALKVSVQSLPRQSNYPVLTCSIHTNIGLYEKRIQQHKLKTHQHHN
PNEAEQCGTNSSQRLCSKQTWTMAPESVLHAKSGPSPEYTAAVKNIKLYPGTGSKSDHGTSQANILGFSGIGDIKSQETSVRTLKSFSMV
DSSISNRQSFWQSAGETNPLIGSLIQERQEIIARIAQHLIHCDPSTSHVSGRPFNTQESSSLHSKLFRVSQENENVGKGKEAFSMTFGSP
EFSSPEDTNEGKIRLKPETPRSETCISNDFYSHMPVGETNPLIGSLLQERQDVIARIAQHLEHIDPTASHIPRQSFNMHDSSSVASKVFR
SSYEDKNLLKKNKDESSVSISHTKCSLLGDISDGKNLVPNKCFTSFKNNSKEKCSLKHQTRNQCQNNPSEIIQSTYQETQNKSSSLSTSS
ILSQHKENNLDLTSRFKEQEMSNGIDKQYSNCTTIDKQICTNKYKEKIINENYNPKFFGNLQSDDSKKNDSKIKVTVLEMSEYLNKYESM
SSNKDSKRPKTCEQNTQLNSIENYLNKDNEGFKCKKSDQLKNEQDKQEDPTNEKSQNYSQRRSIKDCLSTCEQPKNTEVLRTTLKHSNVW
RKHNFHSLDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDSSLLHLKSFSSRSPRPCLNIEDDPDIHEKPFLSSSAPPITSLSLLGNF
EESVLNYRFDPLGIVDGFTAEVGASGAFCPTHLTLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNKTVVKMF
VVIYDLRDMPANHQTFLRQRTFSVPVKQEVKRSVNKENIRHTEERLLRYLIHLRFQSSKSGKIYLHRDVRLLFSRKSMEVDSGAAYELKS

--------------------------------------------------------------
>99527_99527_4_WWP2-FAM214A_WWP2_chr16_69833198_ENST00000569174_FAM214A_chr15_52906054_ENST00000261844_length(transcript)=4458nt_BP=410nt
AGATGAAACAGAAAGGCTAAAGAGGGCTGGAGTCAGGGGACTTCTCTTCCACCAGCTTCACGGTGATGATATGGCATCTGCCAGCTCTAG
CCGGGCAGGAGTGGCCCTGCCTTTTGAGAAGTCTCAGCTCACTTTGAAAGTGGTGTCCGCAAAGCCCAAGGTGCATAATCGTCAACCTCG
AATTAACTCCTACGTGGAGGTGGCGGTGGATGGACTCCCCAGTGAGACCAAGAAGACTGGGAAGCGCATTGGGAGCTCTGAGCTTCTCTG
GAATGAGATCATCATTTTGAATGTCACGGCACAGAGTCATTTAGATTTAAAGGTCTGGAGCTGCCATACCTTGAGAAATGAACTGCTAGG
CACCGCATCTGTCAACCTCTCCAACGTCTTGAAGAACAATGGGGGCAAAAATACTCTGGATGAATATTTTGAATATGATGCAGAGGAGTT
CTTGGTCTCTTTGGCCTTGCTGATAACAGAAGGACGAACACCTGAATGTTCTGTAAAAGGTCGAACAGAAAGCTTTCATTGCCCTCCAGC
ACAGTCTTGTTACCCAGTAACTACCAAACATGAATGTAGTGACAAGCTGGCCCAGTGCCGCCAAGCCAGACGAACTAGGTCTGAGGTCAC
ATTGTTGTGGAAGAATAACCTTCCAATCATGGTGGAAATGATGCTACTACCAGACTGCTGCTACAGCGATGATGGGCCCACCACAGAGGG
AATTGATCTAAATGATCCTGCGATTAAGCAAGATGCATTATTATTAGAAAGATGGATCTTGGAGCCAGTTCCTCGACAGAATGGTGACCG
ATTTATTGAAGAGAAGACGCTTCTGTTGGCTGTCCGCTCATTTGTGTTTTTTTCTCAGTTAAGTGCATGGCTGAGTGTTTCTCATGGTGC
TATTCCACGAAATATTCTCTACAGAATCAGTGCTGCTGATGTAGACCTACAGTGGAATTTTTCACAGACTCCAATTGAGCATGTGTTTCC
TGTTCCCAATGTTTCTCACAATGTTGCCTTGAAAGTCAGTGTTCAGTCCTTGCCCAGACAATCTAATTATCCAGTTTTGACGTGCAGTAT
TCACACTAATATTGGCCTTTATGAGAAAAGAATTCAACAACATAAACTTAAAACTCATCAGCACCATAACCCAAATGAAGCAGAACAATG
TGGTACAAACAGTTCACAGCGTCTGTGTAGCAAACAAACTTGGACCATGGCACCTGAAAGTGTGTTACATGCAAAAAGTGGCCCAAGTCC
AGAATATACTGCAGCTGTCAAAAATATCAAACTATATCCAGGCACTGGCAGTAAATCTGACCATGGGACATCTCAAGCCAATATTCTAGG
CTTTAGTGGTATAGGTGATATAAAATCACAAGAAACATCAGTGAGAACTTTAAAATCATTTTCAATGGTTGATTCCAGTATCTCTAACCG
CCAGAGTTTCTGGCAGTCAGCTGGTGAGACTAACCCTTTAATAGGCTCTTTAATTCAGGAGCGGCAAGAAATCATTGCAAGAATTGCCCA
ACATTTGATTCATTGTGATCCAAGCACTTCACATGTTTCTGGACGTCCATTTAATACTCAAGAGTCTAGTTCACTCCATTCAAAACTTTT
CCGGGTTTCACAAGAAAATGAGAACGTGGGAAAAGGTAAAGAAGCTTTCTCCATGACTTTTGGTAGTCCAGAGTTTAGTTCCCCAGAAGA
CACCAATGAGGGGAAAATTCGACTAAAACCAGAAACTCCTCGAAGTGAAACTTGTATTTCTAATGACTTTTATTCTCATATGCCTGTTGG
AGAGACTAATCCTTTGATAGGCTCTTTACTCCAGGAGCGGCAAGATGTTATTGCAAGGATTGCTCAACACTTGGAGCACATTGATCCAAC
AGCATCACATATCCCCCGGCAGTCATTCAACATGCATGACTCCAGTTCGGTTGCATCTAAAGTGTTTAGGAGTTCATATGAAGACAAAAA
TTTGTTGAAGAAAAATAAGGATGAGTCCTCAGTTTCCATTTCTCACACAAAATGTTCCTTGTTAGGAGACATCAGTGATGGGAAAAACTT
AGTACCTAATAAATGTTTTACTTCTTTTAAAAATAATAGTAAAGAAAAGTGTTCTTTGAAACATCAAACAAGAAATCAGTGTCAGAACAA
TCCTAGTGAAATCATCCAAAGTACGTATCAGGAGACACAGAACAAAAGTTCTAGTTTATCAACTTCCTCAATTTTGTCTCAGCACAAAGA
AAATAACTTAGATTTGACAAGCAGATTCAAGGAGCAAGAAATGAGCAATGGAATTGATAAACAGTATTCAAATTGCACCACTATTGACAA
ACAGATTTGTACAAATAAGTATAAGGAAAAAATAATAAATGAGAACTATAATCCAAAATTCTTTGGCAATCTTCAGTCTGATGATTCCAA
AAAAAATGACTCAAAAATAAAAGTTACTGTGTTGGAAATGTCTGAATATTTGAACAAATATGAAAGCATGTCCTCAAATAAAGACTCAAA
AAGGCCTAAGACATGTGAGCAAAATACTCAACTTAATAGCATAGAGAATTATCTCAATAAAGATAATGAAGGTTTCAAATGTAAAAAGTC
AGACCAATTAAAAAATGAACAAGATAAGCAAGAAGATCCAACTAATGAAAAATCCCAAAACTATTCTCAGAGAAGAAGTATAAAAGACTG
TTTGTCTACATGTGAGCAACCAAAAAATACAGAGGTATTGAGGACTACACTGAAACATTCAAATGTGTGGCGAAAACATAATTTTCATTC
CTTGGATGGAACTTCAACCAGAGCCTTTCATCCTCAAACTGGATTGCCTCTTCTTTCAAGCCCTGTTCCTCAAAGAAAAACACAATCAGG
TTGCTTTGATCTGGATTCTTCATTACTACATCTGAAAAGCTTCTCATCTAGAAGTCCTCGACCATGTTTAAACATTGAAGATGATCCAGA
TATTCATGAAAAACCATTTTTGAGTTCTAGTGCTCCACCTATAACAAGTCTTAGTCTCCTAGGAAATTTTGAGGAATCTGTCTTGAACTA
TCGTTTCGATCCTCTCGGCATTGTTGATGGTTTTACTGCCGAGGTAGGGGCAAGTGGTGCTTTCTGCCCCACACATTTGACTCTTCCAGT
TGAAGTGTCATTCTACAGTGTTTCAGATGACAATGCTCCCTCTCCTTATATGGGTGTGATTACTTTAGAGTCCCTTGGTAAAAGGGGTTA
TCGAGTACCTCCTTCAGGAACAATACAAGTGACCTTATTTAATCCTAATAAGACTGTGGTGAAGATGTTTGTTGTGATATATGATTTACG
AGATATGCCAGCCAATCATCAGACATTCCTACGACAAAGAACTTTTTCTGTACCTGTTAAACAAGAAGTGAAGAGAAGTGTTAATAAAGA
GAACATCCGACACACAGAAGAACGGTTATTACGCTACCTCATACATCTGAGGTTCCAGAGTTCTAAATCTGGAAAGATCTACCTCCATAG
AGACGTACGGCTCCTGTTCTCTAGAAAGTCAATGGAGGTTGATAGCGGTGCTGCATATGAACTCAAATCTTACACTGAATCACCAACAAA
CCCTCAGTTTTCACCAAGATGTTGATAAGGAGTGATGATTTAAAGTATTTACTCAGTACCCAAGTTTGCAAGTAAAAATTAGCATAGAAT
GGAGTGTACCAAATTAACAATCAGGAGAGTGGATTCTCTCCTGTTATCCTGGACCAGTTTTTATGAAAGGATTCCTGAAATGAAATCCAT
ATATTCCATGTAGACTGGAAAAACTCATGTCCTAATCCTTTTTGTACTGTTGAAACCACTTCATTGGACATGTTGCAATAGCAAAACCCC
CAGTTAGATTAGTGTTTACACATTTTCTCAGTTATTTAATATTTAATGTTTTCCTTAATACTCAAGTGATGTTTGTCTCTAGTGTTCTAA
TGTAGCACAAATCCTATGTAAAATCATACTATGTATTTTTGACATTAATGTTGAAATCAAATATATGCACAAGTCTTTAATTTTGTGTAA
TGTGTTAAGTGCTGTTCATTTAAGTTATTGAAAATGAGAATAAAATGTTGAGCTTCTTTAAAAGTAACACACTATGCAAGCATGTGTACT
TTTTATATCTCTCATGTTTAGTTTTTATAACACCATATCCAGGTTGCTATCTCACATAGTAGTCCTTTAACATATTGTATTAGCAGTGCA
ATGTGGACTAAGCTGCTTCACTTTCCCTTTGCAAGTTCAGATCATCATGCCCATTCATAGCCAGGATTCCTTATCCCCAAAACAGTTCTA
TTTTTCCTTAATCACTACTATAGAGTCTTTACATTAAATTACTGTCGTATGCTAGATAATTTTCTCAAATTGTTAAAAGAATATGTACTT

>99527_99527_4_WWP2-FAM214A_WWP2_chr16_69833198_ENST00000569174_FAM214A_chr15_52906054_ENST00000261844_length(amino acids)=1184AA_BP=114
MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSHLDLKVWSCHT
LRNELLGTASVNLSNVLKNNGGKNTLDEYFEYDAEEFLVSLALLITEGRTPECSVKGRTESFHCPPAQSCYPVTTKHECSDKLAQCRQAR
RTRSEVTLLWKNNLPIMVEMMLLPDCCYSDDGPTTEGIDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKTLLLAVRSFVFFSQLSAW
LSVSHGAIPRNILYRISAADVDLQWNFSQTPIEHVFPVPNVSHNVALKVSVQSLPRQSNYPVLTCSIHTNIGLYEKRIQQHKLKTHQHHN
PNEAEQCGTNSSQRLCSKQTWTMAPESVLHAKSGPSPEYTAAVKNIKLYPGTGSKSDHGTSQANILGFSGIGDIKSQETSVRTLKSFSMV
DSSISNRQSFWQSAGETNPLIGSLIQERQEIIARIAQHLIHCDPSTSHVSGRPFNTQESSSLHSKLFRVSQENENVGKGKEAFSMTFGSP
EFSSPEDTNEGKIRLKPETPRSETCISNDFYSHMPVGETNPLIGSLLQERQDVIARIAQHLEHIDPTASHIPRQSFNMHDSSSVASKVFR
SSYEDKNLLKKNKDESSVSISHTKCSLLGDISDGKNLVPNKCFTSFKNNSKEKCSLKHQTRNQCQNNPSEIIQSTYQETQNKSSSLSTSS
ILSQHKENNLDLTSRFKEQEMSNGIDKQYSNCTTIDKQICTNKYKEKIINENYNPKFFGNLQSDDSKKNDSKIKVTVLEMSEYLNKYESM
SSNKDSKRPKTCEQNTQLNSIENYLNKDNEGFKCKKSDQLKNEQDKQEDPTNEKSQNYSQRRSIKDCLSTCEQPKNTEVLRTTLKHSNVW
RKHNFHSLDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDSSLLHLKSFSSRSPRPCLNIEDDPDIHEKPFLSSSAPPITSLSLLGNF
EESVLNYRFDPLGIVDGFTAEVGASGAFCPTHLTLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNKTVVKMF
VVIYDLRDMPANHQTFLRQRTFSVPVKQEVKRSVNKENIRHTEERLLRYLIHLRFQSSKSGKIYLHRDVRLLFSRKSMEVDSGAAYELKS

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Fusion Gene PPI Analysis for WWP2-FAM214A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WWP2-FAM214A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WWP2-FAM214A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource