FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:WWTR1-FOSB (FusionGDB2 ID:99551)

Fusion Gene Summary for WWTR1-FOSB

check button Fusion gene summary
Fusion gene informationFusion gene name: WWTR1-FOSB
Fusion gene ID: 99551
HgeneTgene
Gene symbol

WWTR1

FOSB

Gene ID

25937

2354

Gene nameWW domain containing transcription regulator 1FosB proto-oncogene, AP-1 transcription factor subunit
SynonymsTAZAP-1|G0S3|GOS3|GOSB
Cytomap

3q25.1

19q13.32

Type of geneprotein-codingprotein-coding
DescriptionWW domain-containing transcription regulator protein 1transcriptional co-activator with PDZ-binding motifprotein fosBFBJ murine osteosarcoma viral oncogene homolog BFosB proto-oncogene, AP-1 trancription factor subunitG0/G1 switch regulatory protein 3activator protein 1
Modification date2020031320200313
UniProtAcc.

P53539

Ensembl transtripts involved in fusion geneENST00000360632, ENST00000465804, 
ENST00000467467, ENST00000474080, 
ENST00000353609, ENST00000417353, 
ENST00000443841, ENST00000585836, 
ENST00000586615, ENST00000590335, 
ENST00000591858, ENST00000592436, 
ENST00000592811, 
Fusion gene scores* DoF score12 X 10 X 6=7204 X 4 X 2=32
# samples 122
** MAII scorelog2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/32*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WWTR1 [Title/Abstract] AND FOSB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWTR1

GO:0008284

positive regulation of cell proliferation

18227151

HgeneWWTR1

GO:0010718

positive regulation of epithelial to mesenchymal transition

18227151

HgeneWWTR1

GO:0017145

stem cell division

18568018

HgeneWWTR1

GO:0035329

hippo signaling

18227151|20412773

HgeneWWTR1

GO:0060390

regulation of SMAD protein signal transduction

18568018


check buttonFusion gene breakpoints across WWTR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FOSB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB4..WWTR1chr3

149290787

-FOSBchr19

149290787

+


Top

Fusion Gene ORF analysis for WWTR1-FOSB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000360632ENST00000353609WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000360632ENST00000417353WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000360632ENST00000443841WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000360632ENST00000585836WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000360632ENST00000586615WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000360632ENST00000590335WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000360632ENST00000591858WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000360632ENST00000592436WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000360632ENST00000592811WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000465804ENST00000353609WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000465804ENST00000417353WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000465804ENST00000443841WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000465804ENST00000585836WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000465804ENST00000586615WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000465804ENST00000590335WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000465804ENST00000591858WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000465804ENST00000592436WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000465804ENST00000592811WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000467467ENST00000353609WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000467467ENST00000417353WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000467467ENST00000443841WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000467467ENST00000585836WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000467467ENST00000586615WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000467467ENST00000590335WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000467467ENST00000591858WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000467467ENST00000592436WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000467467ENST00000592811WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000474080ENST00000353609WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000474080ENST00000417353WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000474080ENST00000443841WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000474080ENST00000585836WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000474080ENST00000586615WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000474080ENST00000590335WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000474080ENST00000591858WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000474080ENST00000592436WWTR1chr3

149290787

-FOSBchr19

149290787

+
intron-intronENST00000474080ENST00000592811WWTR1chr3

149290787

-FOSBchr19

149290787

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for WWTR1-FOSB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for WWTR1-FOSB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FOSB

P53539

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: FosB interacts with Jun proteins enhancing their DNA binding activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for WWTR1-FOSB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for WWTR1-FOSB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for WWTR1-FOSB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for WWTR1-FOSB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource