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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:XDH-RPS27A (FusionGDB2 ID:99586)

Fusion Gene Summary for XDH-RPS27A

check button Fusion gene summary
Fusion gene informationFusion gene name: XDH-RPS27A
Fusion gene ID: 99586
HgeneTgene
Gene symbol

XDH

RPS27A

Gene ID

7498

6233

Gene namexanthine dehydrogenaseribosomal protein S27a
SynonymsXAN1|XO|XORCEP80|HEL112|S27A|UBA80|UBC|UBCEP1|UBCEP80
Cytomap

2p23.1

2p16.1

Type of geneprotein-codingprotein-coding
Descriptionxanthine dehydrogenase/oxidasexanthine oxidoreductaseubiquitin-40S ribosomal protein S27a40S ribosomal protein S27aepididymis luminal protein 112ubiquitin Cubiquitin and ribosomal protein S27aubiquitin carboxyl extension protein 80ubiquitin-CEP80
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000379416, ENST00000491727, 
ENST00000272317, ENST00000402285, 
ENST00000404735, 
Fusion gene scores* DoF score1 X 1 X 1=112 X 13 X 6=936
# samples 117
** MAII scorelog2(1/1*10)=3.32192809488736log2(17/936*10)=-2.4609737834457
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XDH [Title/Abstract] AND RPS27A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointXDH(31562355)-RPS27A(55461967), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXDH

GO:0001933

negative regulation of protein phosphorylation

18386220

HgeneXDH

GO:0001937

negative regulation of endothelial cell proliferation

18386220

HgeneXDH

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

18386220

HgeneXDH

GO:0009115

xanthine catabolic process

8670112|17301077

HgeneXDH

GO:0010629

negative regulation of gene expression

18386220

HgeneXDH

GO:0045602

negative regulation of endothelial cell differentiation

18386220

HgeneXDH

GO:0051898

negative regulation of protein kinase B signaling

18386220

HgeneXDH

GO:1900745

positive regulation of p38MAPK cascade

18386220

HgeneXDH

GO:1900747

negative regulation of vascular endothelial growth factor signaling pathway

18386220

HgeneXDH

GO:2000379

positive regulation of reactive oxygen species metabolic process

18386220

HgeneXDH

GO:2001213

negative regulation of vasculogenesis

18386220


check buttonFusion gene breakpoints across XDH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPS27A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A1KR-01AXDHchr2

31562355

-RPS27Achr2

55461967

+


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Fusion Gene ORF analysis for XDH-RPS27A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000379416ENST00000272317XDHchr2

31562355

-RPS27Achr2

55461967

+
In-frameENST00000379416ENST00000402285XDHchr2

31562355

-RPS27Achr2

55461967

+
In-frameENST00000379416ENST00000404735XDHchr2

31562355

-RPS27Achr2

55461967

+
intron-3CDSENST00000491727ENST00000272317XDHchr2

31562355

-RPS27Achr2

55461967

+
intron-3CDSENST00000491727ENST00000402285XDHchr2

31562355

-RPS27Achr2

55461967

+
intron-3CDSENST00000491727ENST00000404735XDHchr2

31562355

-RPS27Achr2

55461967

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000379416XDHchr231562355-ENST00000402285RPS27Achr255461967+411638234941041351
ENST00000379416XDHchr231562355-ENST00000272317RPS27Achr255461967+438138234941041351
ENST00000379416XDHchr231562355-ENST00000404735RPS27Achr255461967+428338234941041351

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379416ENST00000402285XDHchr231562355-RPS27Achr255461967+0.0012059910.99879396
ENST00000379416ENST00000272317XDHchr231562355-RPS27Achr255461967+0.0008550250.9991449
ENST00000379416ENST00000404735XDHchr231562355-RPS27Achr255461967+0.0009865360.9990134

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Fusion Genomic Features for XDH-RPS27A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
XDHchr231562354-RPS27Achr255461966+0.0007243240.99927574
XDHchr231562354-RPS27Achr255461966+0.0007243240.99927574

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for XDH-RPS27A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:31562355/chr2:55461967)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXDHchr2:31562355chr2:55461967ENST00000379416-3436229_41412581334.0DomainFAD-binding PCMH-type
HgeneXDHchr2:31562355chr2:55461967ENST00000379416-34364_9112581334.0Domain2Fe-2S ferredoxin-type
HgeneXDHchr2:31562355chr2:55461967ENST00000379416-3436257_26412581334.0Nucleotide bindingFAD
HgeneXDHchr2:31562355chr2:55461967ENST00000379416-3436347_35112581334.0Nucleotide bindingFAD
TgeneRPS27Achr2:31562355chr2:55461967ENST000002723173677_9963157.0Compositional biasNote=Lys-rich (highly basic)
TgeneRPS27Achr2:31562355chr2:55461967ENST000004022853677_9963157.0Compositional biasNote=Lys-rich (highly basic)
TgeneRPS27Achr2:31562355chr2:55461967ENST000004047352577_9963157.0Compositional biasNote=Lys-rich (highly basic)
TgeneRPS27Achr2:31562355chr2:55461967ENST0000027231736121_14463157.0Zinc fingerNote=C4-type
TgeneRPS27Achr2:31562355chr2:55461967ENST0000040228536121_14463157.0Zinc fingerNote=C4-type
TgeneRPS27Achr2:31562355chr2:55461967ENST0000040473525121_14463157.0Zinc fingerNote=C4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRPS27Achr2:31562355chr2:55461967ENST00000272317361_7663157.0DomainUbiquitin-like
TgeneRPS27Achr2:31562355chr2:55461967ENST00000402285361_7663157.0DomainUbiquitin-like
TgeneRPS27Achr2:31562355chr2:55461967ENST00000404735251_7663157.0DomainUbiquitin-like


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Fusion Gene Sequence for XDH-RPS27A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99586_99586_1_XDH-RPS27A_XDH_chr2_31562355_ENST00000379416_RPS27A_chr2_55461967_ENST00000272317_length(transcript)=4381nt_BP=3823nt
GTCTCTTAGGAGTGAGGTACCTGGAGTTCGGGGACCCCAACCTGTGACAATGACAGCAGACAAATTGGTTTTCTTTGTGAATGGCAGAAA
GGTGGTGGAGAAAAATGCAGATCCAGAGACAACCCTTTTGGCCTACCTGAGAAGAAAGTTGGGGCTGAGTGGAACCAAGCTCGGCTGTGG
AGAGGGGGGCTGCGGGGCTTGCACAGTGATGCTCTCCAAGTATGATCGTCTGCAGAACAAGATCGTCCACTTTTCTGCCAATGCCTGCCT
GGCCCCCATCTGCTCCTTGCACCATGTTGCAGTGACAACTGTGGAAGGAATAGGAAGCACCAAGACGAGGCTGCATCCTGTGCAGGAGAG
AATTGCCAAAAGCCACGGCTCCCAGTGCGGGTTCTGCACCCCTGGCATCGTCATGAGTATGTACACACTGCTCCGGAATCAGCCCGAGCC
CACCATGGAGGAGATTGAGAATGCCTTCCAAGGAAATCTGTGCCGCTGCACAGGCTACAGACCCATCCTCCAGGGCTTCCGGACCTTTGC
CAGGGATGGTGGATGCTGTGGAGGAGATGGGAATAATCCAAATTGCTGCATGAACCAGAAGAAAGACCACTCAGTCAGCCTCTCGCCATC
TTTATTCAAACCAGAGGAGTTCACGCCCCTGGATCCAACCCAGGAGCCCATTTTTCCCCCAGAGTTGCTGAGGCTGAAAGACACTCCTCG
GAAGCAGCTGCGATTTGAAGGGGAGCGTGTGACGTGGATACAGGCCTCAACCCTCAAGGAGCTGCTGGACCTCAAGGCTCAGCACCCTGA
CGCCAAGCTGGTCGTGGGGAACACGGAGATTGGCATTGAGATGAAGTTCAAGAATATGCTGTTTCCTATGATTGTCTGCCCAGCCTGGAT
CCCTGAGCTGAATTCGGTAGAACATGGACCCGACGGTATCTCCTTTGGAGCTGCTTGCCCCCTGAGCATTGTGGAAAAAACCCTGGTGGA
TGCTGTTGCTAAGCTTCCTGCCCAAAAGACAGAGGTGTTCAGAGGGGTCCTGGAGCAGCTGCGCTGGTTTGCTGGGAAGCAAGTCAAGTC
TGTGGCGTCCGTTGGAGGGAACATCATCACTGCCAGCCCCATCTCCGACCTCAACCCCGTGTTCATGGCCAGTGGGGCCAAGCTGACACT
TGTGTCCAGAGGCACCAGGAGAACTGTCCAGATGGACCACACCTTCTTCCCTGGCTACAGAAAGACCCTGCTGAGCCCGGAGGAGATACT
GCTCTCCATAGAGATCCCCTACAGCAGGGAGGGGGAGTATTTCTCAGCATTCAAGCAGGCCTCCCGGAGAGAAGATGACATTGCCAAGGT
AACCAGTGGCATGAGAGTTTTATTCAAGCCAGGAACCACAGAGGTACAGGAGCTGGCCCTTTGCTATGGTGGAATGGCCAACAGAACCAT
CTCAGCCCTCAAGACCACTCAGAGGCAGCTTTCCAAGCTCTGGAAGGAGGAGCTGCTGCAGGACGTGTGTGCAGGACTGGCAGAGGAGCT
GCATCTGCCTCCCGATGCCCCTGGTGGCATGGTGGACTTCCGGTGCACCCTCACCCTCAGCTTCTTCTTCAAGTTCTACCTGACAGTCCT
TCAGAAGCTGGGCCAAGAGAACCTGGAAGACAAGTGTGGTAAACTGGACCCCACTTTCGCCAGTGCAACTTTACTGTTTCAGAAAGACCC
CCCAGCCGATGTCCAGCTCTTCCAAGAGGTGCCCAAGGGTCAGTCTGAGGAGGACATGGTGGGCCGGCCCCTGCCCCACCTGGCAGCGGA
CATGCAGGCCTCTGGTGAGGCCGTGTACTGTGACGACATTCCTCGCTACGAGAATGAGCTGTCTCTCCGGCTGGTCACCAGCACCCGGGC
CCACGCCAAGATCAAGTCCATAGATACATCAGAAGCTAAGAAGGTTCCAGGGTTTGTTTGTTTCATTTCCGCTGATGATGTTCCTGGGAG
TAACATAACTGGAATTTGTAATGATGAGACAGTCTTTGCGAAGGATAAGGTTACTTGTGTTGGGCATATCATTGGTGCTGTGGTTGCTGA
CACCCCGGAACACACACAGAGAGCTGCCCAAGGGGTGAAAATCACCTATGAAGAACTACCAGCCATTATCACAATTGAGGATGCTATAAA
GAACAACTCCTTTTATGGACCTGAGCTGAAGATCGAGAAAGGGGACCTAAAGAAGGGGTTTTCCGAAGCAGATAATGTTGTGTCAGGGGA
GATATACATCGGTGGCCAAGAGCACTTCTACCTGGAGACTCACTGCACCATTGCTGTTCCAAAAGGCGAGGCAGGGGAGATGGAGCTCTT
TGTGTCTACACAGAACACCATGAAGACCCAGAGCTTTGTTGCAAAAATGTTGGGGGTTCCAGCAAACCGGATTGTGGTTCGAGTGAAGAG
AATGGGAGGAGGCTTTGGAGGCAAGGAGACCCGGAGCACTGTGGTGTCCACGGCAGTGGCCCTGGCTGCATATAAGACCGGCCGCCCTGT
GCGATGCATGCTGGACCGTGATGAGGACATGCTGATAACTGGTGGCAGACATCCCTTCCTGGCCAGATACAAGGTTGGCTTCATGAAGAC
TGGGACAGTTGTGGCTCTTGAGGTGGACCACTTCAGCAATGTGGGGAACACCCAGGATCTCTCTCAGAGTATTATGGAACGAGCTTTATT
CCACATGGACAACTGCTATAAAATCCCCAACATCCGGGGCACTGGGCGGCTGTGCAAAACCAACCTTCCCTCCAACACGGCCTTCCGGGG
CTTTGGGGGGCCCCAGGGGATGCTCATTGCCGAGTGCTGGATGAGTGAAGTTGCAGTGACCTGTGGGATGCCTGCAGAGGAGGTGCGGAG
AAAAAACCTGTACAAAGAAGGGGACCTGACACACTTCAACCAGAAGCTTGAGGGTTTCACCTTGCCCAGATGCTGGGAAGAATGCCTAGC
AAGCTCTCAGTATCATGCTCGGAAGAGTGAGGTTGACAAGTTCAACAAGGAGAATTGTTGGAAAAAGAGAGGATTGTGCATAATTCCCAC
CAAGTTTGGAATAAGCTTTACAGTTCCTTTTCTGAATCAGGCAGGAGCCCTACTTCATGTGTACACAGATGGCTCTGTGCTGCTGACCCA
CGGGGGGACTGAGATGGGCCAAGGCCTTCATACCAAAATGGTCCAGGTGGCCAGTAGAGCTCTGAAAATCCCCACCTCTAAGATTTATAT
CAGCGAGACAAGCACTAACACTGTGCCCAACACCTCTCCCACGGCTGCCTCTGTCAGCGCTGACCTCAATGGACAGGCCGTCTATGCGGC
TTGTCAGACCATCTTGAAAAGGCTGGAACCCTACAAGAAGAAGAATCCCAGTGGCTCCTGGGAAGACTGGGTCACAGCTGCCTACATGGA
CACAGTGAGCTTGTCTGCCACTGGGTTTTATAGAACACCCAATCTGGGCTACAGCTTTGAGACTAACTCAGGGAACCCCTTCCACTACTT
CAGCTATGGGGTGGCTTGCTCTGAAGTAGAAATCGACTGCCTAACAGGAGATCATAAGAACCTCCGCACAGATATTGTCATGGATGTTGG
CTCCAGTCTAAACCCTGCCATTGATATTGGACAGGTGGAAGGGGCATTTGTCCAGGGCCTTGGCCTCTTCACCCTAGAGGAGCTACACTA
TTCCCCCGAGGGGAGCCTGCACACCCGTGGCCCTAGCACCTACAAGATCCCGGCATTTGGCAGCATCCCCATTGAGTTCAGGGTGTCCCT
GCTCCGCGACTGCCCCAACAAGAAGGCCATCTATGCATCGAAGGAGTCTACTCTTCATCTTGTGTTGAGACTTCGTGGTGGTGCTAAGAA
AAGGAAGAAGAAGTCTTACACCACTCCCAAGAAGAATAAGCACAAGAGAAAGAAGGTTAAGCTGGCTGTCCTGAAATATTATAAGGTGGA
TGAGAATGGCAAAATTAGTCGCCTTCGTCGAGAGTGCCCTTCTGATGAATGTGGTGCTGGGGTGTTTATGGCAAGTCACTTTGACAGACA
TTATTGTGGCAAATGTTGTCTGACTTACTGTTTCAACAAACCAGAAGACAAGTAACTGTATGAGTTAATAAAAGACATGAACTAACATTT
ATTGTTGGGTTTTATTGCAGTAAAAAGAATGGTTTTTAAGCACCAAATTGATGGTCACACCATTTCCTTTTAGTAGTGCTACTGCTATCG
CTGTGTGAATGTTGCCTCTGGGGATTATGTGACCCAGTGGTTCTGTATACCTGCCAGGTGCCAACCACTTGTAAAGGTCTTGATATTTTC

>99586_99586_1_XDH-RPS27A_XDH_chr2_31562355_ENST00000379416_RPS27A_chr2_55461967_ENST00000272317_length(amino acids)=1351AA_BP=1258
MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSLHHVAVTTVEG
IGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCC
MNQKKDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERVTWIQASTLKELLDLKAQHPDAKLVVGNTEIGIEMKF
KNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISD
LNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQ
ELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLD
PTFASATLLFQKDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVP
GFVCFISADDVPGSNITGICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKGDL
KKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVS
TAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGR
LCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNK
ENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAA
SVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTG
DHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKES
TLHLVLRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYCFNKPED

--------------------------------------------------------------
>99586_99586_2_XDH-RPS27A_XDH_chr2_31562355_ENST00000379416_RPS27A_chr2_55461967_ENST00000402285_length(transcript)=4116nt_BP=3823nt
GTCTCTTAGGAGTGAGGTACCTGGAGTTCGGGGACCCCAACCTGTGACAATGACAGCAGACAAATTGGTTTTCTTTGTGAATGGCAGAAA
GGTGGTGGAGAAAAATGCAGATCCAGAGACAACCCTTTTGGCCTACCTGAGAAGAAAGTTGGGGCTGAGTGGAACCAAGCTCGGCTGTGG
AGAGGGGGGCTGCGGGGCTTGCACAGTGATGCTCTCCAAGTATGATCGTCTGCAGAACAAGATCGTCCACTTTTCTGCCAATGCCTGCCT
GGCCCCCATCTGCTCCTTGCACCATGTTGCAGTGACAACTGTGGAAGGAATAGGAAGCACCAAGACGAGGCTGCATCCTGTGCAGGAGAG
AATTGCCAAAAGCCACGGCTCCCAGTGCGGGTTCTGCACCCCTGGCATCGTCATGAGTATGTACACACTGCTCCGGAATCAGCCCGAGCC
CACCATGGAGGAGATTGAGAATGCCTTCCAAGGAAATCTGTGCCGCTGCACAGGCTACAGACCCATCCTCCAGGGCTTCCGGACCTTTGC
CAGGGATGGTGGATGCTGTGGAGGAGATGGGAATAATCCAAATTGCTGCATGAACCAGAAGAAAGACCACTCAGTCAGCCTCTCGCCATC
TTTATTCAAACCAGAGGAGTTCACGCCCCTGGATCCAACCCAGGAGCCCATTTTTCCCCCAGAGTTGCTGAGGCTGAAAGACACTCCTCG
GAAGCAGCTGCGATTTGAAGGGGAGCGTGTGACGTGGATACAGGCCTCAACCCTCAAGGAGCTGCTGGACCTCAAGGCTCAGCACCCTGA
CGCCAAGCTGGTCGTGGGGAACACGGAGATTGGCATTGAGATGAAGTTCAAGAATATGCTGTTTCCTATGATTGTCTGCCCAGCCTGGAT
CCCTGAGCTGAATTCGGTAGAACATGGACCCGACGGTATCTCCTTTGGAGCTGCTTGCCCCCTGAGCATTGTGGAAAAAACCCTGGTGGA
TGCTGTTGCTAAGCTTCCTGCCCAAAAGACAGAGGTGTTCAGAGGGGTCCTGGAGCAGCTGCGCTGGTTTGCTGGGAAGCAAGTCAAGTC
TGTGGCGTCCGTTGGAGGGAACATCATCACTGCCAGCCCCATCTCCGACCTCAACCCCGTGTTCATGGCCAGTGGGGCCAAGCTGACACT
TGTGTCCAGAGGCACCAGGAGAACTGTCCAGATGGACCACACCTTCTTCCCTGGCTACAGAAAGACCCTGCTGAGCCCGGAGGAGATACT
GCTCTCCATAGAGATCCCCTACAGCAGGGAGGGGGAGTATTTCTCAGCATTCAAGCAGGCCTCCCGGAGAGAAGATGACATTGCCAAGGT
AACCAGTGGCATGAGAGTTTTATTCAAGCCAGGAACCACAGAGGTACAGGAGCTGGCCCTTTGCTATGGTGGAATGGCCAACAGAACCAT
CTCAGCCCTCAAGACCACTCAGAGGCAGCTTTCCAAGCTCTGGAAGGAGGAGCTGCTGCAGGACGTGTGTGCAGGACTGGCAGAGGAGCT
GCATCTGCCTCCCGATGCCCCTGGTGGCATGGTGGACTTCCGGTGCACCCTCACCCTCAGCTTCTTCTTCAAGTTCTACCTGACAGTCCT
TCAGAAGCTGGGCCAAGAGAACCTGGAAGACAAGTGTGGTAAACTGGACCCCACTTTCGCCAGTGCAACTTTACTGTTTCAGAAAGACCC
CCCAGCCGATGTCCAGCTCTTCCAAGAGGTGCCCAAGGGTCAGTCTGAGGAGGACATGGTGGGCCGGCCCCTGCCCCACCTGGCAGCGGA
CATGCAGGCCTCTGGTGAGGCCGTGTACTGTGACGACATTCCTCGCTACGAGAATGAGCTGTCTCTCCGGCTGGTCACCAGCACCCGGGC
CCACGCCAAGATCAAGTCCATAGATACATCAGAAGCTAAGAAGGTTCCAGGGTTTGTTTGTTTCATTTCCGCTGATGATGTTCCTGGGAG
TAACATAACTGGAATTTGTAATGATGAGACAGTCTTTGCGAAGGATAAGGTTACTTGTGTTGGGCATATCATTGGTGCTGTGGTTGCTGA
CACCCCGGAACACACACAGAGAGCTGCCCAAGGGGTGAAAATCACCTATGAAGAACTACCAGCCATTATCACAATTGAGGATGCTATAAA
GAACAACTCCTTTTATGGACCTGAGCTGAAGATCGAGAAAGGGGACCTAAAGAAGGGGTTTTCCGAAGCAGATAATGTTGTGTCAGGGGA
GATATACATCGGTGGCCAAGAGCACTTCTACCTGGAGACTCACTGCACCATTGCTGTTCCAAAAGGCGAGGCAGGGGAGATGGAGCTCTT
TGTGTCTACACAGAACACCATGAAGACCCAGAGCTTTGTTGCAAAAATGTTGGGGGTTCCAGCAAACCGGATTGTGGTTCGAGTGAAGAG
AATGGGAGGAGGCTTTGGAGGCAAGGAGACCCGGAGCACTGTGGTGTCCACGGCAGTGGCCCTGGCTGCATATAAGACCGGCCGCCCTGT
GCGATGCATGCTGGACCGTGATGAGGACATGCTGATAACTGGTGGCAGACATCCCTTCCTGGCCAGATACAAGGTTGGCTTCATGAAGAC
TGGGACAGTTGTGGCTCTTGAGGTGGACCACTTCAGCAATGTGGGGAACACCCAGGATCTCTCTCAGAGTATTATGGAACGAGCTTTATT
CCACATGGACAACTGCTATAAAATCCCCAACATCCGGGGCACTGGGCGGCTGTGCAAAACCAACCTTCCCTCCAACACGGCCTTCCGGGG
CTTTGGGGGGCCCCAGGGGATGCTCATTGCCGAGTGCTGGATGAGTGAAGTTGCAGTGACCTGTGGGATGCCTGCAGAGGAGGTGCGGAG
AAAAAACCTGTACAAAGAAGGGGACCTGACACACTTCAACCAGAAGCTTGAGGGTTTCACCTTGCCCAGATGCTGGGAAGAATGCCTAGC
AAGCTCTCAGTATCATGCTCGGAAGAGTGAGGTTGACAAGTTCAACAAGGAGAATTGTTGGAAAAAGAGAGGATTGTGCATAATTCCCAC
CAAGTTTGGAATAAGCTTTACAGTTCCTTTTCTGAATCAGGCAGGAGCCCTACTTCATGTGTACACAGATGGCTCTGTGCTGCTGACCCA
CGGGGGGACTGAGATGGGCCAAGGCCTTCATACCAAAATGGTCCAGGTGGCCAGTAGAGCTCTGAAAATCCCCACCTCTAAGATTTATAT
CAGCGAGACAAGCACTAACACTGTGCCCAACACCTCTCCCACGGCTGCCTCTGTCAGCGCTGACCTCAATGGACAGGCCGTCTATGCGGC
TTGTCAGACCATCTTGAAAAGGCTGGAACCCTACAAGAAGAAGAATCCCAGTGGCTCCTGGGAAGACTGGGTCACAGCTGCCTACATGGA
CACAGTGAGCTTGTCTGCCACTGGGTTTTATAGAACACCCAATCTGGGCTACAGCTTTGAGACTAACTCAGGGAACCCCTTCCACTACTT
CAGCTATGGGGTGGCTTGCTCTGAAGTAGAAATCGACTGCCTAACAGGAGATCATAAGAACCTCCGCACAGATATTGTCATGGATGTTGG
CTCCAGTCTAAACCCTGCCATTGATATTGGACAGGTGGAAGGGGCATTTGTCCAGGGCCTTGGCCTCTTCACCCTAGAGGAGCTACACTA
TTCCCCCGAGGGGAGCCTGCACACCCGTGGCCCTAGCACCTACAAGATCCCGGCATTTGGCAGCATCCCCATTGAGTTCAGGGTGTCCCT
GCTCCGCGACTGCCCCAACAAGAAGGCCATCTATGCATCGAAGGAGTCTACTCTTCATCTTGTGTTGAGACTTCGTGGTGGTGCTAAGAA
AAGGAAGAAGAAGTCTTACACCACTCCCAAGAAGAATAAGCACAAGAGAAAGAAGGTTAAGCTGGCTGTCCTGAAATATTATAAGGTGGA
TGAGAATGGCAAAATTAGTCGCCTTCGTCGAGAGTGCCCTTCTGATGAATGTGGTGCTGGGGTGTTTATGGCAAGTCACTTTGACAGACA

>99586_99586_2_XDH-RPS27A_XDH_chr2_31562355_ENST00000379416_RPS27A_chr2_55461967_ENST00000402285_length(amino acids)=1351AA_BP=1258
MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSLHHVAVTTVEG
IGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCC
MNQKKDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERVTWIQASTLKELLDLKAQHPDAKLVVGNTEIGIEMKF
KNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISD
LNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQ
ELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLD
PTFASATLLFQKDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVP
GFVCFISADDVPGSNITGICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKGDL
KKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVS
TAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGR
LCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNK
ENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAA
SVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTG
DHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKES
TLHLVLRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYCFNKPED

--------------------------------------------------------------
>99586_99586_3_XDH-RPS27A_XDH_chr2_31562355_ENST00000379416_RPS27A_chr2_55461967_ENST00000404735_length(transcript)=4283nt_BP=3823nt
GTCTCTTAGGAGTGAGGTACCTGGAGTTCGGGGACCCCAACCTGTGACAATGACAGCAGACAAATTGGTTTTCTTTGTGAATGGCAGAAA
GGTGGTGGAGAAAAATGCAGATCCAGAGACAACCCTTTTGGCCTACCTGAGAAGAAAGTTGGGGCTGAGTGGAACCAAGCTCGGCTGTGG
AGAGGGGGGCTGCGGGGCTTGCACAGTGATGCTCTCCAAGTATGATCGTCTGCAGAACAAGATCGTCCACTTTTCTGCCAATGCCTGCCT
GGCCCCCATCTGCTCCTTGCACCATGTTGCAGTGACAACTGTGGAAGGAATAGGAAGCACCAAGACGAGGCTGCATCCTGTGCAGGAGAG
AATTGCCAAAAGCCACGGCTCCCAGTGCGGGTTCTGCACCCCTGGCATCGTCATGAGTATGTACACACTGCTCCGGAATCAGCCCGAGCC
CACCATGGAGGAGATTGAGAATGCCTTCCAAGGAAATCTGTGCCGCTGCACAGGCTACAGACCCATCCTCCAGGGCTTCCGGACCTTTGC
CAGGGATGGTGGATGCTGTGGAGGAGATGGGAATAATCCAAATTGCTGCATGAACCAGAAGAAAGACCACTCAGTCAGCCTCTCGCCATC
TTTATTCAAACCAGAGGAGTTCACGCCCCTGGATCCAACCCAGGAGCCCATTTTTCCCCCAGAGTTGCTGAGGCTGAAAGACACTCCTCG
GAAGCAGCTGCGATTTGAAGGGGAGCGTGTGACGTGGATACAGGCCTCAACCCTCAAGGAGCTGCTGGACCTCAAGGCTCAGCACCCTGA
CGCCAAGCTGGTCGTGGGGAACACGGAGATTGGCATTGAGATGAAGTTCAAGAATATGCTGTTTCCTATGATTGTCTGCCCAGCCTGGAT
CCCTGAGCTGAATTCGGTAGAACATGGACCCGACGGTATCTCCTTTGGAGCTGCTTGCCCCCTGAGCATTGTGGAAAAAACCCTGGTGGA
TGCTGTTGCTAAGCTTCCTGCCCAAAAGACAGAGGTGTTCAGAGGGGTCCTGGAGCAGCTGCGCTGGTTTGCTGGGAAGCAAGTCAAGTC
TGTGGCGTCCGTTGGAGGGAACATCATCACTGCCAGCCCCATCTCCGACCTCAACCCCGTGTTCATGGCCAGTGGGGCCAAGCTGACACT
TGTGTCCAGAGGCACCAGGAGAACTGTCCAGATGGACCACACCTTCTTCCCTGGCTACAGAAAGACCCTGCTGAGCCCGGAGGAGATACT
GCTCTCCATAGAGATCCCCTACAGCAGGGAGGGGGAGTATTTCTCAGCATTCAAGCAGGCCTCCCGGAGAGAAGATGACATTGCCAAGGT
AACCAGTGGCATGAGAGTTTTATTCAAGCCAGGAACCACAGAGGTACAGGAGCTGGCCCTTTGCTATGGTGGAATGGCCAACAGAACCAT
CTCAGCCCTCAAGACCACTCAGAGGCAGCTTTCCAAGCTCTGGAAGGAGGAGCTGCTGCAGGACGTGTGTGCAGGACTGGCAGAGGAGCT
GCATCTGCCTCCCGATGCCCCTGGTGGCATGGTGGACTTCCGGTGCACCCTCACCCTCAGCTTCTTCTTCAAGTTCTACCTGACAGTCCT
TCAGAAGCTGGGCCAAGAGAACCTGGAAGACAAGTGTGGTAAACTGGACCCCACTTTCGCCAGTGCAACTTTACTGTTTCAGAAAGACCC
CCCAGCCGATGTCCAGCTCTTCCAAGAGGTGCCCAAGGGTCAGTCTGAGGAGGACATGGTGGGCCGGCCCCTGCCCCACCTGGCAGCGGA
CATGCAGGCCTCTGGTGAGGCCGTGTACTGTGACGACATTCCTCGCTACGAGAATGAGCTGTCTCTCCGGCTGGTCACCAGCACCCGGGC
CCACGCCAAGATCAAGTCCATAGATACATCAGAAGCTAAGAAGGTTCCAGGGTTTGTTTGTTTCATTTCCGCTGATGATGTTCCTGGGAG
TAACATAACTGGAATTTGTAATGATGAGACAGTCTTTGCGAAGGATAAGGTTACTTGTGTTGGGCATATCATTGGTGCTGTGGTTGCTGA
CACCCCGGAACACACACAGAGAGCTGCCCAAGGGGTGAAAATCACCTATGAAGAACTACCAGCCATTATCACAATTGAGGATGCTATAAA
GAACAACTCCTTTTATGGACCTGAGCTGAAGATCGAGAAAGGGGACCTAAAGAAGGGGTTTTCCGAAGCAGATAATGTTGTGTCAGGGGA
GATATACATCGGTGGCCAAGAGCACTTCTACCTGGAGACTCACTGCACCATTGCTGTTCCAAAAGGCGAGGCAGGGGAGATGGAGCTCTT
TGTGTCTACACAGAACACCATGAAGACCCAGAGCTTTGTTGCAAAAATGTTGGGGGTTCCAGCAAACCGGATTGTGGTTCGAGTGAAGAG
AATGGGAGGAGGCTTTGGAGGCAAGGAGACCCGGAGCACTGTGGTGTCCACGGCAGTGGCCCTGGCTGCATATAAGACCGGCCGCCCTGT
GCGATGCATGCTGGACCGTGATGAGGACATGCTGATAACTGGTGGCAGACATCCCTTCCTGGCCAGATACAAGGTTGGCTTCATGAAGAC
TGGGACAGTTGTGGCTCTTGAGGTGGACCACTTCAGCAATGTGGGGAACACCCAGGATCTCTCTCAGAGTATTATGGAACGAGCTTTATT
CCACATGGACAACTGCTATAAAATCCCCAACATCCGGGGCACTGGGCGGCTGTGCAAAACCAACCTTCCCTCCAACACGGCCTTCCGGGG
CTTTGGGGGGCCCCAGGGGATGCTCATTGCCGAGTGCTGGATGAGTGAAGTTGCAGTGACCTGTGGGATGCCTGCAGAGGAGGTGCGGAG
AAAAAACCTGTACAAAGAAGGGGACCTGACACACTTCAACCAGAAGCTTGAGGGTTTCACCTTGCCCAGATGCTGGGAAGAATGCCTAGC
AAGCTCTCAGTATCATGCTCGGAAGAGTGAGGTTGACAAGTTCAACAAGGAGAATTGTTGGAAAAAGAGAGGATTGTGCATAATTCCCAC
CAAGTTTGGAATAAGCTTTACAGTTCCTTTTCTGAATCAGGCAGGAGCCCTACTTCATGTGTACACAGATGGCTCTGTGCTGCTGACCCA
CGGGGGGACTGAGATGGGCCAAGGCCTTCATACCAAAATGGTCCAGGTGGCCAGTAGAGCTCTGAAAATCCCCACCTCTAAGATTTATAT
CAGCGAGACAAGCACTAACACTGTGCCCAACACCTCTCCCACGGCTGCCTCTGTCAGCGCTGACCTCAATGGACAGGCCGTCTATGCGGC
TTGTCAGACCATCTTGAAAAGGCTGGAACCCTACAAGAAGAAGAATCCCAGTGGCTCCTGGGAAGACTGGGTCACAGCTGCCTACATGGA
CACAGTGAGCTTGTCTGCCACTGGGTTTTATAGAACACCCAATCTGGGCTACAGCTTTGAGACTAACTCAGGGAACCCCTTCCACTACTT
CAGCTATGGGGTGGCTTGCTCTGAAGTAGAAATCGACTGCCTAACAGGAGATCATAAGAACCTCCGCACAGATATTGTCATGGATGTTGG
CTCCAGTCTAAACCCTGCCATTGATATTGGACAGGTGGAAGGGGCATTTGTCCAGGGCCTTGGCCTCTTCACCCTAGAGGAGCTACACTA
TTCCCCCGAGGGGAGCCTGCACACCCGTGGCCCTAGCACCTACAAGATCCCGGCATTTGGCAGCATCCCCATTGAGTTCAGGGTGTCCCT
GCTCCGCGACTGCCCCAACAAGAAGGCCATCTATGCATCGAAGGAGTCTACTCTTCATCTTGTGTTGAGACTTCGTGGTGGTGCTAAGAA
AAGGAAGAAGAAGTCTTACACCACTCCCAAGAAGAATAAGCACAAGAGAAAGAAGGTTAAGCTGGCTGTCCTGAAATATTATAAGGTGGA
TGAGAATGGCAAAATTAGTCGCCTTCGTCGAGAGTGCCCTTCTGATGAATGTGGTGCTGGGGTGTTTATGGCAAGTCACTTTGACAGACA
TTATTGTGGCAAATGTTGTCTGACTTACTGTTTCAACAAACCAGAAGACAAGTAACTGTATGAGTTAATAAAAGACATGAACTAACATTT
ATTGTTGGGTTTTATTGCAGTAAAAAGAATGGTTTTTAAGCACCAAATTGATGGTCACACCATTTCCTTTTAGTAGTGCTACTGCTATCG

>99586_99586_3_XDH-RPS27A_XDH_chr2_31562355_ENST00000379416_RPS27A_chr2_55461967_ENST00000404735_length(amino acids)=1351AA_BP=1258
MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSLHHVAVTTVEG
IGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCC
MNQKKDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERVTWIQASTLKELLDLKAQHPDAKLVVGNTEIGIEMKF
KNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISD
LNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQ
ELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLD
PTFASATLLFQKDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVP
GFVCFISADDVPGSNITGICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKGDL
KKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVS
TAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGR
LCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNK
ENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAA
SVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTG
DHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKES
TLHLVLRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYCFNKPED

--------------------------------------------------------------

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Fusion Gene PPI Analysis for XDH-RPS27A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for XDH-RPS27A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for XDH-RPS27A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource