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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:XIAP-SH2D1A (FusionGDB2 ID:99597)

Fusion Gene Summary for XIAP-SH2D1A

check button Fusion gene summary
Fusion gene informationFusion gene name: XIAP-SH2D1A
Fusion gene ID: 99597
HgeneTgene
Gene symbol

XIAP

SH2D1A

Gene ID

331

4068

Gene nameX-linked inhibitor of apoptosisSH2 domain containing 1A
SynonymsAPI3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3DSHP|EBVS|IMD5|LYP|MTCP1|SAP|SAP/SH2D1A|XLP|XLPD|XLPD1
Cytomap

Xq25

Xq25

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase XIAPIAP-like proteinIAP-like protein 1RING-type E3 ubiquitin transferase XIAPX-linked IAPX-linked inhibitor of apoptosis, E3 ubiquitin protein ligasebaculoviral IAP repeat-containing protein 4inhibitor of apoptosis proteSH2 domain-containing protein 1ADuncan disease SH2-proteinSLAM associated protein/SH2 domain protein 1ASLAM-associated proteinT cell signal transduction molecule SAPsignaling lymphocyte activation molecule-associated proteinsignaling lymphocytic act
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000468691, ENST00000355640, 
ENST00000371199, ENST00000434753, 
ENST00000360027, ENST00000371139, 
ENST00000477673, ENST00000491950, 
Fusion gene scores* DoF score9 X 7 X 6=3783 X 2 X 3=18
# samples 93
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: XIAP [Title/Abstract] AND SH2D1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointXIAP(123022568)-SH2D1A(123499611), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXIAP

GO:0031398

positive regulation of protein ubiquitination

21931591

HgeneXIAP

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

11583623

HgeneXIAP

GO:1902530

positive regulation of protein linear polyubiquitination

21931591

TgeneSH2D1A

GO:0007267

cell-cell signaling

9774102


check buttonFusion gene breakpoints across XIAP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SH2D1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-F5-6810XIAPchrX

123022568

+SH2D1AchrX

123499611

+


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Fusion Gene ORF analysis for XIAP-SH2D1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000468691ENST00000360027XIAPchrX

123022568

+SH2D1AchrX

123499611

+
3UTR-3CDSENST00000468691ENST00000371139XIAPchrX

123022568

+SH2D1AchrX

123499611

+
3UTR-intronENST00000468691ENST00000477673XIAPchrX

123022568

+SH2D1AchrX

123499611

+
3UTR-intronENST00000468691ENST00000491950XIAPchrX

123022568

+SH2D1AchrX

123499611

+
5CDS-intronENST00000355640ENST00000477673XIAPchrX

123022568

+SH2D1AchrX

123499611

+
5CDS-intronENST00000355640ENST00000491950XIAPchrX

123022568

+SH2D1AchrX

123499611

+
5CDS-intronENST00000371199ENST00000477673XIAPchrX

123022568

+SH2D1AchrX

123499611

+
5CDS-intronENST00000371199ENST00000491950XIAPchrX

123022568

+SH2D1AchrX

123499611

+
5CDS-intronENST00000434753ENST00000477673XIAPchrX

123022568

+SH2D1AchrX

123499611

+
5CDS-intronENST00000434753ENST00000491950XIAPchrX

123022568

+SH2D1AchrX

123499611

+
In-frameENST00000355640ENST00000360027XIAPchrX

123022568

+SH2D1AchrX

123499611

+
In-frameENST00000355640ENST00000371139XIAPchrX

123022568

+SH2D1AchrX

123499611

+
In-frameENST00000371199ENST00000360027XIAPchrX

123022568

+SH2D1AchrX

123499611

+
In-frameENST00000371199ENST00000371139XIAPchrX

123022568

+SH2D1AchrX

123499611

+
In-frameENST00000434753ENST00000360027XIAPchrX

123022568

+SH2D1AchrX

123499611

+
In-frameENST00000434753ENST00000371139XIAPchrX

123022568

+SH2D1AchrX

123499611

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000434753XIAPchrX123022568+ENST00000371139SH2D1AchrX123499611+3117110361352448
ENST00000434753XIAPchrX123022568+ENST00000360027SH2D1AchrX123499611+1441110361343445
ENST00000371199XIAPchrX123022568+ENST00000371139SH2D1AchrX123499611+329012761791525448
ENST00000371199XIAPchrX123022568+ENST00000360027SH2D1AchrX123499611+161412761791516445
ENST00000355640XIAPchrX123022568+ENST00000371139SH2D1AchrX123499611+329712833061532408
ENST00000355640XIAPchrX123022568+ENST00000360027SH2D1AchrX123499611+162112833061523405

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000434753ENST00000371139XIAPchrX123022568+SH2D1AchrX123499611+0.0001171920.9998828
ENST00000434753ENST00000360027XIAPchrX123022568+SH2D1AchrX123499611+0.0006780220.99932194
ENST00000371199ENST00000371139XIAPchrX123022568+SH2D1AchrX123499611+0.0001294160.99987054
ENST00000371199ENST00000360027XIAPchrX123022568+SH2D1AchrX123499611+0.0007148630.99928516
ENST00000355640ENST00000371139XIAPchrX123022568+SH2D1AchrX123499611+0.0001197680.9998802
ENST00000355640ENST00000360027XIAPchrX123022568+SH2D1AchrX123499611+0.0007243370.9992756

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Fusion Genomic Features for XIAP-SH2D1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
XIAPchrX123022568+SH2D1AchrX123499610+1.62E-081
XIAPchrX123022568+SH2D1AchrX123499610+1.62E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for XIAP-SH2D1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:123022568/chrX:123499611)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXIAPchrX:123022568chrX:123499611ENST00000355640+37163_230325498.0RepeatNote=BIR 2
HgeneXIAPchrX:123022568chrX:123499611ENST00000355640+3726_93325498.0RepeatNote=BIR 1
HgeneXIAPchrX:123022568chrX:123499611ENST00000371199+37163_230325498.0RepeatNote=BIR 2
HgeneXIAPchrX:123022568chrX:123499611ENST00000371199+3726_93325498.0RepeatNote=BIR 1
HgeneXIAPchrX:123022568chrX:123499611ENST00000434753+37163_230325498.0RepeatNote=BIR 2
HgeneXIAPchrX:123022568chrX:123499611ENST00000434753+3726_93325498.0RepeatNote=BIR 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXIAPchrX:123022568chrX:123499611ENST00000355640+37265_330325498.0RepeatNote=BIR 3
HgeneXIAPchrX:123022568chrX:123499611ENST00000371199+37265_330325498.0RepeatNote=BIR 3
HgeneXIAPchrX:123022568chrX:123499611ENST00000434753+37265_330325498.0RepeatNote=BIR 3
HgeneXIAPchrX:123022568chrX:123499611ENST00000355640+37450_485325498.0Zinc fingerRING-type
HgeneXIAPchrX:123022568chrX:123499611ENST00000371199+37450_485325498.0Zinc fingerRING-type
HgeneXIAPchrX:123022568chrX:123499611ENST00000434753+37450_485325498.0Zinc fingerRING-type
TgeneSH2D1AchrX:123022568chrX:123499611ENST00000360027046_10445126.0DomainSH2
TgeneSH2D1AchrX:123022568chrX:123499611ENST00000371139046_10445129.0DomainSH2


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Fusion Gene Sequence for XIAP-SH2D1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99597_99597_1_XIAP-SH2D1A_XIAP_chrX_123022568_ENST00000355640_SH2D1A_chrX_123499611_ENST00000360027_length(transcript)=1621nt_BP=1283nt
TCGGGCCGGCTGTCCTGGCGCGGTGGGTACAGCTTGTGTAGGCTTTCCCCTCCCCCGCTTTCCCTCCTTCCCCTCTCCTCCCTCCCCTCT
TCTTTTCCCCTCCACTTCCCTCGGGCCGGCGCTGCTGGGGAGGGCGGGAAGGCCGCGCCAGCCCATCAGGGGTGGCCCGGCCCCGGCTGC
TTGCCCGGGTTCCTCGGACTGCCGACGGCAGGCGTGGGTGGGTGGGTGACTTCAGGCCTGCAGGATTGCCTTCCTAAACCCTGTGACACC
TAAGAAAAGGTGGACAAGTCCTATTTTCAAGAGAAGATGACTTTTAACAGTTTTGAAGGATCTAAAACTTGTGTACCTGCAGACATCAAT
AAGGAAGAAGAATTTGTAGAAGAGTTTAATAGATTAAAAACTTTTGCTAATTTTCCAAGTGGTAGTCCTGTTTCAGCATCAACACTGGCA
CGAGCAGGGTTTCTTTATACTGGTGAAGGAGATACCGTGCGGTGCTTTAGTTGTCATGCAGCTGTAGATAGATGGCAATATGGAGACTCA
GCAGTTGGAAGACACAGGAAAGTATCCCCAAATTGCAGATTTATCAACGGCTTTTATCTTGAAAATAGTGCCACGCAGTCTACAAATTCT
GGTATCCAGAATGGTCAGTACAAAGTTGAAAACTATCTGGGAAGCAGAGATCATTTTGCCTTAGACAGGCCATCTGAGACACATGCAGAC
TATCTTTTGAGAACTGGGCAGGTTGTAGATATATCAGACACCATATACCCGAGGAACCCTGCCATGTATAGTGAAGAAGCTAGATTAAAG
TCCTTTCAGAACTGGCCAGACTATGCTCACCTAACCCCAAGAGAGTTAGCAAGTGCTGGACTCTACTACACAGGTATTGGTGACCAAGTG
CAGTGCTTTTGTTGTGGTGGAAAACTGAAAAATTGGGAACCTTGTGATCGTGCCTGGTCAGAACACAGGCGACACTTTCCTAATTGCTTC
TTTGTTTTGGGCCGGAATCTTAATATTCGAAGTGAATCTGATGCTGTGAGTTCTGATAGGAATTTCCCAAATTCAACAAATCTTCCAAGA
AATCCATCCATGGCAGATTATGAAGCACGGATCTTTACTTTTGGGACATGGATATACTCAGTTAACAAGGAGCAGCTTGCAAGAGCTGGA
TTTTATGCTTTAGGTGAAGGTGATAAAGTAAAGTGCTTTCACTGTGGAGGAGGGCTAACTGATTGGAAGCCCAGTGAAGACCCTTGGGAA
CAACATGCTAAATGGTATCCAGGGTATCACGGTTACATTTATACATACCGAGTGTCCCAGACAGAAACAGGTTCTTGGAGTGCTGAGACA
GCACCTGGGGTACATAAAAGATATTTCCGGAAAATAAAAAATCTCATTTCAGCATTTCAGAAGCCAGATCAAGGCATTGTAATACCTCTG
CAGTATCCAGTTGAGAAGAAGTCCTCAGCTAGAAGTACACAAGGGATAAGAGAAGATCCTGATGTCTGCCTGAAAGCCCCATGAAGAAAA
ATAAAACACCTTGTACTTTATTTTCTATAATTTAAATATATGCTAAGTCTTATATATTGTAGATAATACAGTTCGGTGAGCTACAAATGC

>99597_99597_1_XIAP-SH2D1A_XIAP_chrX_123022568_ENST00000355640_SH2D1A_chrX_123499611_ENST00000360027_length(amino acids)=405AA_BP=0
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNC
RFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIF
TFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGYHGYIYTYRVSQTETGSWSAETAPGVHKRYFRKI

--------------------------------------------------------------
>99597_99597_2_XIAP-SH2D1A_XIAP_chrX_123022568_ENST00000355640_SH2D1A_chrX_123499611_ENST00000371139_length(transcript)=3297nt_BP=1283nt
TCGGGCCGGCTGTCCTGGCGCGGTGGGTACAGCTTGTGTAGGCTTTCCCCTCCCCCGCTTTCCCTCCTTCCCCTCTCCTCCCTCCCCTCT
TCTTTTCCCCTCCACTTCCCTCGGGCCGGCGCTGCTGGGGAGGGCGGGAAGGCCGCGCCAGCCCATCAGGGGTGGCCCGGCCCCGGCTGC
TTGCCCGGGTTCCTCGGACTGCCGACGGCAGGCGTGGGTGGGTGGGTGACTTCAGGCCTGCAGGATTGCCTTCCTAAACCCTGTGACACC
TAAGAAAAGGTGGACAAGTCCTATTTTCAAGAGAAGATGACTTTTAACAGTTTTGAAGGATCTAAAACTTGTGTACCTGCAGACATCAAT
AAGGAAGAAGAATTTGTAGAAGAGTTTAATAGATTAAAAACTTTTGCTAATTTTCCAAGTGGTAGTCCTGTTTCAGCATCAACACTGGCA
CGAGCAGGGTTTCTTTATACTGGTGAAGGAGATACCGTGCGGTGCTTTAGTTGTCATGCAGCTGTAGATAGATGGCAATATGGAGACTCA
GCAGTTGGAAGACACAGGAAAGTATCCCCAAATTGCAGATTTATCAACGGCTTTTATCTTGAAAATAGTGCCACGCAGTCTACAAATTCT
GGTATCCAGAATGGTCAGTACAAAGTTGAAAACTATCTGGGAAGCAGAGATCATTTTGCCTTAGACAGGCCATCTGAGACACATGCAGAC
TATCTTTTGAGAACTGGGCAGGTTGTAGATATATCAGACACCATATACCCGAGGAACCCTGCCATGTATAGTGAAGAAGCTAGATTAAAG
TCCTTTCAGAACTGGCCAGACTATGCTCACCTAACCCCAAGAGAGTTAGCAAGTGCTGGACTCTACTACACAGGTATTGGTGACCAAGTG
CAGTGCTTTTGTTGTGGTGGAAAACTGAAAAATTGGGAACCTTGTGATCGTGCCTGGTCAGAACACAGGCGACACTTTCCTAATTGCTTC
TTTGTTTTGGGCCGGAATCTTAATATTCGAAGTGAATCTGATGCTGTGAGTTCTGATAGGAATTTCCCAAATTCAACAAATCTTCCAAGA
AATCCATCCATGGCAGATTATGAAGCACGGATCTTTACTTTTGGGACATGGATATACTCAGTTAACAAGGAGCAGCTTGCAAGAGCTGGA
TTTTATGCTTTAGGTGAAGGTGATAAAGTAAAGTGCTTTCACTGTGGAGGAGGGCTAACTGATTGGAAGCCCAGTGAAGACCCTTGGGAA
CAACATGCTAAATGGTATCCAGGGTATCACGGTTACATTTATACATACCGAGTGTCCCAGACAGAAACAGGTTCTTGGAGTGCTGAGACA
GCACCTGGGGTACATAAAAGATATTTCCGGAAAATAAAAAATCTCATTTCAGCATTTCAGAAGCCAGATCAAGGCATTGTAATACCTCTG
CAGTATCCAGTTGAGAAGAAGTCCTCAGCTAGAAGTACACAAGGTACTACAGGGATAAGAGAAGATCCTGATGTCTGCCTGAAAGCCCCA
TGAAGAAAAATAAAACACCTTGTACTTTATTTTCTATAATTTAAATATATGCTAAGTCTTATATATTGTAGATAATACAGTTCGGTGAGC
TACAAATGCATTTCTAAAGCCATTGTAGTCCTGTAATGGAAGCATCTAGCATGTCGTCAAAGCTGAAATGGACTTTTGTACATAGTGAGG
AGCTTTGAAACGAGGATTGGGAAAAAGTAATTCCGTAGGTTATTTTCAGTTATTATATTTACAAATGGGAAACAAAAGGATAATGAATAC
TTTATAAAGGATTAATGTCAATTCTTGCCAAATATAAATAAAAATAATCCTCAGTTTTTGTGAAAAGCTCCATTTTTAGTGAAATATTAT
TTTATAGCTACTAATTTTAAAATGTCTTGCTTGATTGTATGGTGGGAAGTTGGCTGGTGTCCCTTGTCTTTGCCAAGTTCTCCACTAGCT
ATGGTGTCATAGGCTCTTTTGGGATTTTTGAAGCTGTATACTGTGTGCTAAAACAAGCACTAAACAAAGAGTGAAGGATTTATGTTTAAT
TCTGAAAGCAACCTTCTTGCCTAGTGTTCTGATATTGGACAGTAAAATCCACAGACCAACCTGGAGTTGAAAATCTTATAATTTAAAATA
TGCTCTAAACATGTTTATCGTATTTGATGCTACAGGATTTGAAATTGTATTACAAATCCAATGAAATGAGTTTTTCTTTTCATTTACCTC
TGCCCCAGTTGTTTCTACTACATGGAAGACCTCATTTTGAAGGGAAATTTCAGCAGCTGCAGCTCATGAGTAACTGATTTGTAACAAGCC
TCCTTTTAAAGTAACCCTACAAAACCACTGGAAAGTTTATGGTTGTATTATTTTTTAAAAAAATTCCAAGTGATTGAAACCTACACGAGA
TACAGAATTTTATGCGGCATTTTCTTCTCACATTTATATTTTTGTGATTTTGTGATTGATTATATGTCACTTTGCTACAGGGCTCACAGA
ATTCATTCACTCAACAAACATAATAGGGCGCTGAGGGCATAGAAGTAAAAACACCTGGTCCCTGCTCTCAGTTCACTGTCTTGTTGGACG
AGAAAACAATAACGATAAAAGACAGTGAAAGAAAATAACGATAAAAGACAGTGAAAGAAAATAACAATAAAAGACAAGGAAAAAATAACA
ATGAAAGTTGATAAGTACATGATAAGCGAGGTTCCCCGTGTGTAGGTAGATCTGGTCTTTAGAGGCAGATAGATAGGTCAGTGCAAATAC
TCTGGTCCATGGGCCATATGAAAAGGCTAAGCTTCACTGTAAAATAATAACTGGGAATTCTGGATTGTGTATGGGTGTTGGTGAACTTGG
TTTTAATTAGTGAACTGCTGAGAGACAGAGCTATTCTCCATGTACTGGCAAGACCTGATTTCTGAGCATTTAATATGGATGCCGTGGGAG
TACAAAAGTGGAGTGTGGCCTGAGTAATGCATTATGGGTGGTTTACCATTTCTTGAGGTAAAAGCATCACATGAACTTGTAAAGGAATTT
AAAAATCCTACTTTCATAATAAGTTGCATAGGTTTAATAATTTTTAATTATATGGCTTGAGTTTAAATTGTAATAGGCGTAACTAATTTT
AACTCTATAATGTGTTCATTCTGGAATAATCCTAAACATATGAATTATGTTTGCATGTTCACTTCCAAGAGCCTTTTTTTGAAAAAAAGC

>99597_99597_2_XIAP-SH2D1A_XIAP_chrX_123022568_ENST00000355640_SH2D1A_chrX_123499611_ENST00000371139_length(amino acids)=408AA_BP=0
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNC
RFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIF
TFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGYHGYIYTYRVSQTETGSWSAETAPGVHKRYFRKI

--------------------------------------------------------------
>99597_99597_3_XIAP-SH2D1A_XIAP_chrX_123022568_ENST00000371199_SH2D1A_chrX_123499611_ENST00000360027_length(transcript)=1614nt_BP=1276nt
TGACGGACCGCGCCCGGTGTCTCTTTGAGGCCCTGACGTGGACACACTTCGGGTTTCACGACTCCGGGTTTCTCCAGGGGATGGGCCGGC
CGGTAGAGGCGCGTGAGGGAGACGAAGGGACTTCCGTTTCCTTCACCTAGGCTGGGGCCAAGCCGCAGAGCGGAGTTGGCATTTCCAGAT
TGGGGCTCGGGCCGCGCCTCCTCCGGGACCCTCCCCTTGGACCGAGCCGATCGCCGCGGGGCAGTTCGGGCCGGCTGTCCTGGCGCGAAA
AGGTGGACAAGTCCTATTTTCAAGAGAAGATGACTTTTAACAGTTTTGAAGGATCTAAAACTTGTGTACCTGCAGACATCAATAAGGAAG
AAGAATTTGTAGAAGAGTTTAATAGATTAAAAACTTTTGCTAATTTTCCAAGTGGTAGTCCTGTTTCAGCATCAACACTGGCACGAGCAG
GGTTTCTTTATACTGGTGAAGGAGATACCGTGCGGTGCTTTAGTTGTCATGCAGCTGTAGATAGATGGCAATATGGAGACTCAGCAGTTG
GAAGACACAGGAAAGTATCCCCAAATTGCAGATTTATCAACGGCTTTTATCTTGAAAATAGTGCCACGCAGTCTACAAATTCTGGTATCC
AGAATGGTCAGTACAAAGTTGAAAACTATCTGGGAAGCAGAGATCATTTTGCCTTAGACAGGCCATCTGAGACACATGCAGACTATCTTT
TGAGAACTGGGCAGGTTGTAGATATATCAGACACCATATACCCGAGGAACCCTGCCATGTATAGTGAAGAAGCTAGATTAAAGTCCTTTC
AGAACTGGCCAGACTATGCTCACCTAACCCCAAGAGAGTTAGCAAGTGCTGGACTCTACTACACAGGTATTGGTGACCAAGTGCAGTGCT
TTTGTTGTGGTGGAAAACTGAAAAATTGGGAACCTTGTGATCGTGCCTGGTCAGAACACAGGCGACACTTTCCTAATTGCTTCTTTGTTT
TGGGCCGGAATCTTAATATTCGAAGTGAATCTGATGCTGTGAGTTCTGATAGGAATTTCCCAAATTCAACAAATCTTCCAAGAAATCCAT
CCATGGCAGATTATGAAGCACGGATCTTTACTTTTGGGACATGGATATACTCAGTTAACAAGGAGCAGCTTGCAAGAGCTGGATTTTATG
CTTTAGGTGAAGGTGATAAAGTAAAGTGCTTTCACTGTGGAGGAGGGCTAACTGATTGGAAGCCCAGTGAAGACCCTTGGGAACAACATG
CTAAATGGTATCCAGGGTATCACGGTTACATTTATACATACCGAGTGTCCCAGACAGAAACAGGTTCTTGGAGTGCTGAGACAGCACCTG
GGGTACATAAAAGATATTTCCGGAAAATAAAAAATCTCATTTCAGCATTTCAGAAGCCAGATCAAGGCATTGTAATACCTCTGCAGTATC
CAGTTGAGAAGAAGTCCTCAGCTAGAAGTACACAAGGGATAAGAGAAGATCCTGATGTCTGCCTGAAAGCCCCATGAAGAAAAATAAAAC

>99597_99597_3_XIAP-SH2D1A_XIAP_chrX_123022568_ENST00000371199_SH2D1A_chrX_123499611_ENST00000360027_length(amino acids)=445AA_BP=1
MGLGPRLLRDPPLGPSRSPRGSSGRLSWREKVDKSYFQEKMTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARA
GFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYL
LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFV
LGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQH

--------------------------------------------------------------
>99597_99597_4_XIAP-SH2D1A_XIAP_chrX_123022568_ENST00000371199_SH2D1A_chrX_123499611_ENST00000371139_length(transcript)=3290nt_BP=1276nt
TGACGGACCGCGCCCGGTGTCTCTTTGAGGCCCTGACGTGGACACACTTCGGGTTTCACGACTCCGGGTTTCTCCAGGGGATGGGCCGGC
CGGTAGAGGCGCGTGAGGGAGACGAAGGGACTTCCGTTTCCTTCACCTAGGCTGGGGCCAAGCCGCAGAGCGGAGTTGGCATTTCCAGAT
TGGGGCTCGGGCCGCGCCTCCTCCGGGACCCTCCCCTTGGACCGAGCCGATCGCCGCGGGGCAGTTCGGGCCGGCTGTCCTGGCGCGAAA
AGGTGGACAAGTCCTATTTTCAAGAGAAGATGACTTTTAACAGTTTTGAAGGATCTAAAACTTGTGTACCTGCAGACATCAATAAGGAAG
AAGAATTTGTAGAAGAGTTTAATAGATTAAAAACTTTTGCTAATTTTCCAAGTGGTAGTCCTGTTTCAGCATCAACACTGGCACGAGCAG
GGTTTCTTTATACTGGTGAAGGAGATACCGTGCGGTGCTTTAGTTGTCATGCAGCTGTAGATAGATGGCAATATGGAGACTCAGCAGTTG
GAAGACACAGGAAAGTATCCCCAAATTGCAGATTTATCAACGGCTTTTATCTTGAAAATAGTGCCACGCAGTCTACAAATTCTGGTATCC
AGAATGGTCAGTACAAAGTTGAAAACTATCTGGGAAGCAGAGATCATTTTGCCTTAGACAGGCCATCTGAGACACATGCAGACTATCTTT
TGAGAACTGGGCAGGTTGTAGATATATCAGACACCATATACCCGAGGAACCCTGCCATGTATAGTGAAGAAGCTAGATTAAAGTCCTTTC
AGAACTGGCCAGACTATGCTCACCTAACCCCAAGAGAGTTAGCAAGTGCTGGACTCTACTACACAGGTATTGGTGACCAAGTGCAGTGCT
TTTGTTGTGGTGGAAAACTGAAAAATTGGGAACCTTGTGATCGTGCCTGGTCAGAACACAGGCGACACTTTCCTAATTGCTTCTTTGTTT
TGGGCCGGAATCTTAATATTCGAAGTGAATCTGATGCTGTGAGTTCTGATAGGAATTTCCCAAATTCAACAAATCTTCCAAGAAATCCAT
CCATGGCAGATTATGAAGCACGGATCTTTACTTTTGGGACATGGATATACTCAGTTAACAAGGAGCAGCTTGCAAGAGCTGGATTTTATG
CTTTAGGTGAAGGTGATAAAGTAAAGTGCTTTCACTGTGGAGGAGGGCTAACTGATTGGAAGCCCAGTGAAGACCCTTGGGAACAACATG
CTAAATGGTATCCAGGGTATCACGGTTACATTTATACATACCGAGTGTCCCAGACAGAAACAGGTTCTTGGAGTGCTGAGACAGCACCTG
GGGTACATAAAAGATATTTCCGGAAAATAAAAAATCTCATTTCAGCATTTCAGAAGCCAGATCAAGGCATTGTAATACCTCTGCAGTATC
CAGTTGAGAAGAAGTCCTCAGCTAGAAGTACACAAGGTACTACAGGGATAAGAGAAGATCCTGATGTCTGCCTGAAAGCCCCATGAAGAA
AAATAAAACACCTTGTACTTTATTTTCTATAATTTAAATATATGCTAAGTCTTATATATTGTAGATAATACAGTTCGGTGAGCTACAAAT
GCATTTCTAAAGCCATTGTAGTCCTGTAATGGAAGCATCTAGCATGTCGTCAAAGCTGAAATGGACTTTTGTACATAGTGAGGAGCTTTG
AAACGAGGATTGGGAAAAAGTAATTCCGTAGGTTATTTTCAGTTATTATATTTACAAATGGGAAACAAAAGGATAATGAATACTTTATAA
AGGATTAATGTCAATTCTTGCCAAATATAAATAAAAATAATCCTCAGTTTTTGTGAAAAGCTCCATTTTTAGTGAAATATTATTTTATAG
CTACTAATTTTAAAATGTCTTGCTTGATTGTATGGTGGGAAGTTGGCTGGTGTCCCTTGTCTTTGCCAAGTTCTCCACTAGCTATGGTGT
CATAGGCTCTTTTGGGATTTTTGAAGCTGTATACTGTGTGCTAAAACAAGCACTAAACAAAGAGTGAAGGATTTATGTTTAATTCTGAAA
GCAACCTTCTTGCCTAGTGTTCTGATATTGGACAGTAAAATCCACAGACCAACCTGGAGTTGAAAATCTTATAATTTAAAATATGCTCTA
AACATGTTTATCGTATTTGATGCTACAGGATTTGAAATTGTATTACAAATCCAATGAAATGAGTTTTTCTTTTCATTTACCTCTGCCCCA
GTTGTTTCTACTACATGGAAGACCTCATTTTGAAGGGAAATTTCAGCAGCTGCAGCTCATGAGTAACTGATTTGTAACAAGCCTCCTTTT
AAAGTAACCCTACAAAACCACTGGAAAGTTTATGGTTGTATTATTTTTTAAAAAAATTCCAAGTGATTGAAACCTACACGAGATACAGAA
TTTTATGCGGCATTTTCTTCTCACATTTATATTTTTGTGATTTTGTGATTGATTATATGTCACTTTGCTACAGGGCTCACAGAATTCATT
CACTCAACAAACATAATAGGGCGCTGAGGGCATAGAAGTAAAAACACCTGGTCCCTGCTCTCAGTTCACTGTCTTGTTGGACGAGAAAAC
AATAACGATAAAAGACAGTGAAAGAAAATAACGATAAAAGACAGTGAAAGAAAATAACAATAAAAGACAAGGAAAAAATAACAATGAAAG
TTGATAAGTACATGATAAGCGAGGTTCCCCGTGTGTAGGTAGATCTGGTCTTTAGAGGCAGATAGATAGGTCAGTGCAAATACTCTGGTC
CATGGGCCATATGAAAAGGCTAAGCTTCACTGTAAAATAATAACTGGGAATTCTGGATTGTGTATGGGTGTTGGTGAACTTGGTTTTAAT
TAGTGAACTGCTGAGAGACAGAGCTATTCTCCATGTACTGGCAAGACCTGATTTCTGAGCATTTAATATGGATGCCGTGGGAGTACAAAA
GTGGAGTGTGGCCTGAGTAATGCATTATGGGTGGTTTACCATTTCTTGAGGTAAAAGCATCACATGAACTTGTAAAGGAATTTAAAAATC
CTACTTTCATAATAAGTTGCATAGGTTTAATAATTTTTAATTATATGGCTTGAGTTTAAATTGTAATAGGCGTAACTAATTTTAACTCTA
TAATGTGTTCATTCTGGAATAATCCTAAACATATGAATTATGTTTGCATGTTCACTTCCAAGAGCCTTTTTTTGAAAAAAAGCTTTTTTT

>99597_99597_4_XIAP-SH2D1A_XIAP_chrX_123022568_ENST00000371199_SH2D1A_chrX_123499611_ENST00000371139_length(amino acids)=448AA_BP=1
MGLGPRLLRDPPLGPSRSPRGSSGRLSWREKVDKSYFQEKMTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARA
GFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYL
LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFV
LGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQH

--------------------------------------------------------------
>99597_99597_5_XIAP-SH2D1A_XIAP_chrX_123022568_ENST00000434753_SH2D1A_chrX_123499611_ENST00000360027_length(transcript)=1441nt_BP=1103nt
TTCTTACTGCCCCCATCCGGTTCGGGGAGGTGGCGGGACCTTGGCGGCGCCCGGAGCCGGCGTGGCGCTCATCGAGGGACGCCCGGCCCA
AGTGAAAAGGTGGACAAGTCCTATTTTCAAGAGAAGATGACTTTTAACAGTTTTGAAGGATCTAAAACTTGTGTACCTGCAGACATCAAT
AAGGAAGAAGAATTTGTAGAAGAGTTTAATAGATTAAAAACTTTTGCTAATTTTCCAAGTGGTAGTCCTGTTTCAGCATCAACACTGGCA
CGAGCAGGGTTTCTTTATACTGGTGAAGGAGATACCGTGCGGTGCTTTAGTTGTCATGCAGCTGTAGATAGATGGCAATATGGAGACTCA
GCAGTTGGAAGACACAGGAAAGTATCCCCAAATTGCAGATTTATCAACGGCTTTTATCTTGAAAATAGTGCCACGCAGTCTACAAATTCT
GGTATCCAGAATGGTCAGTACAAAGTTGAAAACTATCTGGGAAGCAGAGATCATTTTGCCTTAGACAGGCCATCTGAGACACATGCAGAC
TATCTTTTGAGAACTGGGCAGGTTGTAGATATATCAGACACCATATACCCGAGGAACCCTGCCATGTATAGTGAAGAAGCTAGATTAAAG
TCCTTTCAGAACTGGCCAGACTATGCTCACCTAACCCCAAGAGAGTTAGCAAGTGCTGGACTCTACTACACAGGTATTGGTGACCAAGTG
CAGTGCTTTTGTTGTGGTGGAAAACTGAAAAATTGGGAACCTTGTGATCGTGCCTGGTCAGAACACAGGCGACACTTTCCTAATTGCTTC
TTTGTTTTGGGCCGGAATCTTAATATTCGAAGTGAATCTGATGCTGTGAGTTCTGATAGGAATTTCCCAAATTCAACAAATCTTCCAAGA
AATCCATCCATGGCAGATTATGAAGCACGGATCTTTACTTTTGGGACATGGATATACTCAGTTAACAAGGAGCAGCTTGCAAGAGCTGGA
TTTTATGCTTTAGGTGAAGGTGATAAAGTAAAGTGCTTTCACTGTGGAGGAGGGCTAACTGATTGGAAGCCCAGTGAAGACCCTTGGGAA
CAACATGCTAAATGGTATCCAGGGTATCACGGTTACATTTATACATACCGAGTGTCCCAGACAGAAACAGGTTCTTGGAGTGCTGAGACA
GCACCTGGGGTACATAAAAGATATTTCCGGAAAATAAAAAATCTCATTTCAGCATTTCAGAAGCCAGATCAAGGCATTGTAATACCTCTG
CAGTATCCAGTTGAGAAGAAGTCCTCAGCTAGAAGTACACAAGGGATAAGAGAAGATCCTGATGTCTGCCTGAAAGCCCCATGAAGAAAA
ATAAAACACCTTGTACTTTATTTTCTATAATTTAAATATATGCTAAGTCTTATATATTGTAGATAATACAGTTCGGTGAGCTACAAATGC

>99597_99597_5_XIAP-SH2D1A_XIAP_chrX_123022568_ENST00000434753_SH2D1A_chrX_123499611_ENST00000360027_length(amino acids)=445AA_BP=1
MPPSGSGRWRDLGGARSRRGAHRGTPGPSEKVDKSYFQEKMTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARA
GFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYL
LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFV
LGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQH

--------------------------------------------------------------
>99597_99597_6_XIAP-SH2D1A_XIAP_chrX_123022568_ENST00000434753_SH2D1A_chrX_123499611_ENST00000371139_length(transcript)=3117nt_BP=1103nt
TTCTTACTGCCCCCATCCGGTTCGGGGAGGTGGCGGGACCTTGGCGGCGCCCGGAGCCGGCGTGGCGCTCATCGAGGGACGCCCGGCCCA
AGTGAAAAGGTGGACAAGTCCTATTTTCAAGAGAAGATGACTTTTAACAGTTTTGAAGGATCTAAAACTTGTGTACCTGCAGACATCAAT
AAGGAAGAAGAATTTGTAGAAGAGTTTAATAGATTAAAAACTTTTGCTAATTTTCCAAGTGGTAGTCCTGTTTCAGCATCAACACTGGCA
CGAGCAGGGTTTCTTTATACTGGTGAAGGAGATACCGTGCGGTGCTTTAGTTGTCATGCAGCTGTAGATAGATGGCAATATGGAGACTCA
GCAGTTGGAAGACACAGGAAAGTATCCCCAAATTGCAGATTTATCAACGGCTTTTATCTTGAAAATAGTGCCACGCAGTCTACAAATTCT
GGTATCCAGAATGGTCAGTACAAAGTTGAAAACTATCTGGGAAGCAGAGATCATTTTGCCTTAGACAGGCCATCTGAGACACATGCAGAC
TATCTTTTGAGAACTGGGCAGGTTGTAGATATATCAGACACCATATACCCGAGGAACCCTGCCATGTATAGTGAAGAAGCTAGATTAAAG
TCCTTTCAGAACTGGCCAGACTATGCTCACCTAACCCCAAGAGAGTTAGCAAGTGCTGGACTCTACTACACAGGTATTGGTGACCAAGTG
CAGTGCTTTTGTTGTGGTGGAAAACTGAAAAATTGGGAACCTTGTGATCGTGCCTGGTCAGAACACAGGCGACACTTTCCTAATTGCTTC
TTTGTTTTGGGCCGGAATCTTAATATTCGAAGTGAATCTGATGCTGTGAGTTCTGATAGGAATTTCCCAAATTCAACAAATCTTCCAAGA
AATCCATCCATGGCAGATTATGAAGCACGGATCTTTACTTTTGGGACATGGATATACTCAGTTAACAAGGAGCAGCTTGCAAGAGCTGGA
TTTTATGCTTTAGGTGAAGGTGATAAAGTAAAGTGCTTTCACTGTGGAGGAGGGCTAACTGATTGGAAGCCCAGTGAAGACCCTTGGGAA
CAACATGCTAAATGGTATCCAGGGTATCACGGTTACATTTATACATACCGAGTGTCCCAGACAGAAACAGGTTCTTGGAGTGCTGAGACA
GCACCTGGGGTACATAAAAGATATTTCCGGAAAATAAAAAATCTCATTTCAGCATTTCAGAAGCCAGATCAAGGCATTGTAATACCTCTG
CAGTATCCAGTTGAGAAGAAGTCCTCAGCTAGAAGTACACAAGGTACTACAGGGATAAGAGAAGATCCTGATGTCTGCCTGAAAGCCCCA
TGAAGAAAAATAAAACACCTTGTACTTTATTTTCTATAATTTAAATATATGCTAAGTCTTATATATTGTAGATAATACAGTTCGGTGAGC
TACAAATGCATTTCTAAAGCCATTGTAGTCCTGTAATGGAAGCATCTAGCATGTCGTCAAAGCTGAAATGGACTTTTGTACATAGTGAGG
AGCTTTGAAACGAGGATTGGGAAAAAGTAATTCCGTAGGTTATTTTCAGTTATTATATTTACAAATGGGAAACAAAAGGATAATGAATAC
TTTATAAAGGATTAATGTCAATTCTTGCCAAATATAAATAAAAATAATCCTCAGTTTTTGTGAAAAGCTCCATTTTTAGTGAAATATTAT
TTTATAGCTACTAATTTTAAAATGTCTTGCTTGATTGTATGGTGGGAAGTTGGCTGGTGTCCCTTGTCTTTGCCAAGTTCTCCACTAGCT
ATGGTGTCATAGGCTCTTTTGGGATTTTTGAAGCTGTATACTGTGTGCTAAAACAAGCACTAAACAAAGAGTGAAGGATTTATGTTTAAT
TCTGAAAGCAACCTTCTTGCCTAGTGTTCTGATATTGGACAGTAAAATCCACAGACCAACCTGGAGTTGAAAATCTTATAATTTAAAATA
TGCTCTAAACATGTTTATCGTATTTGATGCTACAGGATTTGAAATTGTATTACAAATCCAATGAAATGAGTTTTTCTTTTCATTTACCTC
TGCCCCAGTTGTTTCTACTACATGGAAGACCTCATTTTGAAGGGAAATTTCAGCAGCTGCAGCTCATGAGTAACTGATTTGTAACAAGCC
TCCTTTTAAAGTAACCCTACAAAACCACTGGAAAGTTTATGGTTGTATTATTTTTTAAAAAAATTCCAAGTGATTGAAACCTACACGAGA
TACAGAATTTTATGCGGCATTTTCTTCTCACATTTATATTTTTGTGATTTTGTGATTGATTATATGTCACTTTGCTACAGGGCTCACAGA
ATTCATTCACTCAACAAACATAATAGGGCGCTGAGGGCATAGAAGTAAAAACACCTGGTCCCTGCTCTCAGTTCACTGTCTTGTTGGACG
AGAAAACAATAACGATAAAAGACAGTGAAAGAAAATAACGATAAAAGACAGTGAAAGAAAATAACAATAAAAGACAAGGAAAAAATAACA
ATGAAAGTTGATAAGTACATGATAAGCGAGGTTCCCCGTGTGTAGGTAGATCTGGTCTTTAGAGGCAGATAGATAGGTCAGTGCAAATAC
TCTGGTCCATGGGCCATATGAAAAGGCTAAGCTTCACTGTAAAATAATAACTGGGAATTCTGGATTGTGTATGGGTGTTGGTGAACTTGG
TTTTAATTAGTGAACTGCTGAGAGACAGAGCTATTCTCCATGTACTGGCAAGACCTGATTTCTGAGCATTTAATATGGATGCCGTGGGAG
TACAAAAGTGGAGTGTGGCCTGAGTAATGCATTATGGGTGGTTTACCATTTCTTGAGGTAAAAGCATCACATGAACTTGTAAAGGAATTT
AAAAATCCTACTTTCATAATAAGTTGCATAGGTTTAATAATTTTTAATTATATGGCTTGAGTTTAAATTGTAATAGGCGTAACTAATTTT
AACTCTATAATGTGTTCATTCTGGAATAATCCTAAACATATGAATTATGTTTGCATGTTCACTTCCAAGAGCCTTTTTTTGAAAAAAAGC

>99597_99597_6_XIAP-SH2D1A_XIAP_chrX_123022568_ENST00000434753_SH2D1A_chrX_123499611_ENST00000371139_length(amino acids)=448AA_BP=1
MPPSGSGRWRDLGGARSRRGAHRGTPGPSEKVDKSYFQEKMTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARA
GFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYL
LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFV
LGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for XIAP-SH2D1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneXIAPchrX:123022568chrX:123499611ENST00000355640+37141_149325.6666666666667498.0caspase-7
HgeneXIAPchrX:123022568chrX:123499611ENST00000371199+37141_149325.6666666666667498.0caspase-7
HgeneXIAPchrX:123022568chrX:123499611ENST00000434753+37141_149325.6666666666667498.0caspase-7
TgeneSH2D1AchrX:123022568chrX:123499611ENST000003600270467_9245.666666666666664126.0FYN SH3 domain
TgeneSH2D1AchrX:123022568chrX:123499611ENST000003711390467_9245.666666666666664129.0FYN SH3 domain


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for XIAP-SH2D1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for XIAP-SH2D1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource