Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:XPC-RCOR1 (FusionGDB2 ID:99632)

Fusion Gene Summary for XPC-RCOR1

Fusion gene summary

Fusion gene information	Fusion gene name: XPC-RCOR1
	Fusion gene ID: 99632
		Hgene	Tgene
	Gene symbol	XPC	RCOR1
	Gene ID	7508	23186
	Gene name	XPC complex subunit, DNA damage recognition and repair factor	REST corepressor 1
	Synonyms	RAD4\|XP3\|XPCC\|p125	COREST\|RCOR
	Cytomap	3p25.1	14q32.31-q32.32
	Type of gene	protein-coding	protein-coding
	Description	DNA repair protein complementing XP-C cellsmutant xeroderma pigmentosum group Cxeroderma pigmentosum, complementation group C	REST corepressor 1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000285021, ENST00000449060,	ENST00000262241, ENST00000570597,
Fusion gene scores	* DoF score	5 X 5 X 3=75	13 X 15 X 4=780
	# samples	5	15
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/780*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: XPC [Title/Abstract] AND RCOR1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	XPC(14209757)-RCOR1(103177272), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	XPC	GO:0000715	nucleotide-excision repair, DNA damage recognition	10873465\|19941824
Hgene	XPC	GO:0006289	nucleotide-excision repair	8168482\|9734359\|11259578
Hgene	XPC	GO:0045893	positive regulation of transcription, DNA-templated	29973595\|31527837
Hgene	XPC	GO:0070914	UV-damage excision repair	8077226
Tgene	RCOR1	GO:0045892	negative regulation of transcription, DNA-templated	10449787
Tgene	RCOR1	GO:0070933	histone H4 deacetylation	17555596

Fusion gene breakpoints across XPC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RCOR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A06Q-01A	XPC	chr3	14209757	-	RCOR1	chr14	103177272	+

Top

Fusion Gene ORF analysis for XPC-RCOR1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000285021	ENST00000262241	XPC	chr3	14209757	-	RCOR1	chr14	103177272	+
In-frame	ENST00000285021	ENST00000570597	XPC	chr3	14209757	-	RCOR1	chr14	103177272	+
In-frame	ENST00000449060	ENST00000262241	XPC	chr3	14209757	-	RCOR1	chr14	103177272	+
In-frame	ENST00000449060	ENST00000570597	XPC	chr3	14209757	-	RCOR1	chr14	103177272	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000285021	XPC	chr3	14209757	-	ENST00000262241	RCOR1	chr14	103177272	+	5500	751	215	1429	404
ENST00000285021	XPC	chr3	14209757	-	ENST00000570597	RCOR1	chr14	103177272	+	5499	751	215	1429	404
ENST00000449060	XPC	chr3	14209757	-	ENST00000262241	RCOR1	chr14	103177272	+	5174	425	0	1103	367
ENST00000449060	XPC	chr3	14209757	-	ENST00000570597	RCOR1	chr14	103177272	+	5173	425	0	1103	367

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000285021	ENST00000262241	XPC	chr3	14209757	-	RCOR1	chr14	103177272	+	0.000159763	0.99984026
ENST00000285021	ENST00000570597	XPC	chr3	14209757	-	RCOR1	chr14	103177272	+	0.000159247	0.99984074
ENST00000449060	ENST00000262241	XPC	chr3	14209757	-	RCOR1	chr14	103177272	+	0.000153316	0.9998467
ENST00000449060	ENST00000570597	XPC	chr3	14209757	-	RCOR1	chr14	103177272	+	0.000152904	0.99984705

Top

Fusion Genomic Features for XPC-RCOR1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
XPC	chr3	14209756	-	RCOR1	chr14	103177271	+	1.35E-06	0.9999987
XPC	chr3	14209756	-	RCOR1	chr14	103177271	+	1.35E-06	0.9999987

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for XPC-RCOR1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:14209757/chr14:103177272)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000285021

124_130

178

941.0

Compositional bias

Note=Poly-Glu

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000285021

30_177

178

941.0

Compositional bias

Note=Glu-rich (acidic)

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000285021

30_34

178

941.0

Compositional bias

Note=Poly-Glu

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000449060

124_130

141

904.0

Compositional bias

Note=Poly-Glu

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000449060

30_34

141

904.0

Compositional bias

Note=Poly-Glu

Tgene

RCOR1

chr3:14209757

chr14:103177272

ENST00000570597

334_369

256

483.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

RCOR1

chr3:14209757

chr14:103177272

ENST00000570597

381_432

256

483.0

Domain

SANT 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000285021

359_395

178

941.0

Compositional bias

Note=Lys-rich (basic)

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000285021

408_431

178

941.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000285021

432_461

178

941.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000285021

466_493

178

941.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000285021

501_507

178

941.0

Compositional bias

Note=Poly-Ser

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000449060

30_177

141

904.0

Compositional bias

Note=Glu-rich (acidic)

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000449060

359_395

141

904.0

Compositional bias

Note=Lys-rich (basic)

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000449060

408_431

141

904.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000449060

432_461

141

904.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000449060

466_493

141

904.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000449060

501_507

141

904.0

Compositional bias

Note=Poly-Ser

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000285021

390_395

178

941.0

Motif

Nuclear localization signal

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000449060

390_395

141

904.0

Motif

Nuclear localization signal

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000285021

607_741

178

941.0

Region

Note=DNA-binding%3B preference for heteroduplex DNA

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000285021

607_766

178

941.0

Region

Note=Minimal sensor domain involved in damage recognition

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000285021

767_831

178

941.0

Region

Note=DNA-binding%3B preference for single stranded DNA%3B required for formation of stable nucleoprotein complex

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000449060

607_741

141

904.0

Region

Note=DNA-binding%3B preference for heteroduplex DNA

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000449060

607_766

141

904.0

Region

Note=Minimal sensor domain involved in damage recognition

Hgene

XPC

chr3:14209757

chr14:103177272

ENST00000449060

767_831

141

904.0

Region

Note=DNA-binding%3B preference for single stranded DNA%3B required for formation of stable nucleoprotein complex

Tgene

RCOR1

chr3:14209757

chr14:103177272

ENST00000570597

244_273

256

483.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

RCOR1

chr3:14209757

chr14:103177272

ENST00000570597

21_77

256

483.0

Compositional bias

Note=Ala-rich

Tgene

RCOR1

chr3:14209757

chr14:103177272

ENST00000570597

103_189

256

483.0

Domain

ELM2

Tgene

RCOR1

chr3:14209757

chr14:103177272

ENST00000570597

190_241

256

483.0

Domain

SANT 1

Top

Fusion Gene Sequence for XPC-RCOR1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>99632_99632_1_XPC-RCOR1_XPC_chr3_14209757_ENST00000285021_RCOR1_chr14_103177272_ENST00000262241_length(transcript)=5500nt_BP=751nt
ATACACCGGAAATAGAGAGAAACCTGTTGTGCTCTTTCCTGCTTCCCGCAGTTTTTTAGTGGCCACGGGTATGGGGTGGAGCTTCCTTTA
GGGGCGTGACTAGGCCTCCAACGAAGGGGCGTGGCCAAGCGCACCGCCTCGGGGCGGGGCCGGCGTTCTAGCGCATCGCGGCCGGGTGCG
TCACTCGCGAAGTGGAATTTGCCCAGACAAGCAACATGGCTCGGAAACGCGCGGCCGGCGGGGAGCCGCGGGGACGCGAACTGCGCAGCC
AGAAATCCAAGGCCAAGAGCAAGGCCCGGCGTGAGGAGGAGGAGGAGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCT
CCAAAGTTTCACAAGGAAAGAGGAAAAGAGGCTGCAGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGA
CTGTTAAATCTGAAAACCTCAAGGTTATAAAGGATGAAGCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGG
CACACCATCTGAAGAGAGGGGCTACCATGAATGAAGACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGTTGAAGAAC
TTAGTGAGCCTGTGCTGGGTGACGTGAGAGAAAGTACAGCCTTCTCTCGATCTCTTCTGCCTGTGAAGCCAGTGGAGATAGAGATTGAAA
CGCCAGAGCAGGCGAAGACAAGAGAAAGAAGCGAGGATGAACTGGAAGAGGCAAATGGAAACAATCCCATTGACATTGAGGTTGATCAAA
ACAAGGAAAGCAAAAAGGAGGTTCCCCCTACTGAGACAGTTCCTCAGGTCAAAAAAGAAAAACATAGCACACAAGCTAAAAATAGAGCAA
AAAGGAAACCTCCAAAAGGAATGTTTCTTTCTCAAGAAGATGTGGAGGCTGTTTCTGCCAATGCCACTGCTGCTACCACGGTGCTGAGAC
AACTAGACATGGAATTGGTTTCAGTCAAACGACAGATCCAGAATATTAAACAGACAAACAGTGCTCTCAAAGAAAAACTTGATGGTGGAA
TAGAACCATATCGACTTCCAGAGGTCATTCAGAAATGTAATGCACGTTGGACTACAGAAGAGCAGCTTCTCGCCGTACAAGCCATCAGGA
AATATGGCCGAGATTTTCAGGCAATCTCAGACGTGATTGGGAACAAATCAGTGGTACAAGTGAAAAACTTTTTTGTAAATTATCGACGCC
GCTTCAACATAGATGAAGTTTTACAAGAATGGGAGGCAGAACATGGTAAAGAAGAGACCAATGGGCCCAGTAACCAGAAGCCTGTGAAGT
CCCCAGATAATTCCATTAAGATGCCCGAAGAGGAAGACGAGGCTCCTGTTCTGGATGTCAGATATGCATCTGCCTCCTGAGAAACTGGTG
GCTTTGAACACTTGGTGTGGACTACTGTGTTATCCGGGATATCAGGTATTATGAGACATCACCTAGCCATCTGCATCACATCTCTCTGGA
CAAGCAGCTATTACCAAAAAAGGCATATACTTCCAGTCCTGTGCTCCATCTGCCTTAATTCTTTGCTCGTTCCTCCATGTTGGCGCCACT
TCCCAGAGAGCTCCACTGCATCTCACACTCTGCCCACGTGCTGGGGAAGTCTCACGGCCTGCACATCTCTTGTGACTCTGGGAACCGCCT
CTCCCGCCGGAGCCCCCGAGCCCCACCAATGGCAGCTCTTCCCAGTCAGCAGCTTCAGAGCAGGCAGTCTCCTTGGAAGGCCCGACTCTG
TTCCTGCATGGCCTGCAGTTTCTACTTTGTGCATAGAGTCATTTTCAGAGTCACCGCGACCCTGTTGGCCTTCTAGAAAGTTTCTTTTGT
TCTTTTCTGAGACAACCACCTAAGTGATAATACGCTTTTTTGGAAACTAATATATATTGCCAGACTGCATCATAACCTTTATCATGCCAA
GCATCCTGATGCAACTCACATTTCCCTAAACATGGGGTACAGTTATGATTTATAAATTGAGTTGGCTTAAATCTCCCTCTTCTCCCTTCC
CAAGTGTTACAAAGATCATTTACTGCAACTGTCGTTGGACACTGTAGCTTAAAGGGAACGTGGACCTCAATGCTTTCTGCCTTCAACTTT
TCAGCATTGTGACCCCAGGGTGGTTGCCACCCCATCTTTTCCTGACCCCCCCCACCCCCCCACCTCCAAGAGGTTCGGCCCACATCACTG
TACCTGGTGCTTGTAAATTTGGAATTGGTGCCTTCTCCTTTTGGCAACCATGGTTATCAATCCTTTTTCTGTTTTAGTGTCTTATTTCTT
CTTTCAAGTTATTTGCTAGCCAAAGATGACATCACTGAGATTAGGAGACAGGGGAGAGCTTGCTGCAGATTCTGACAGTGCAGATTTTAA
ATGTCAGGATATTAGAATAGCTGGCGCTGGTTTATGAAAGCTGCGCGTTGTTCCGCGTTCTCTCGGTGTGCCTGGCCTTTTATGTGGCAC
TCTGTATGTCAGTTTGTGTCCTTCATGTGCTGATGTGATTACACAAACACCATGCACTCTCTTTTCATATCAGAGTACAGGACAGAGAAG
TGATCAATGTATTGGTCTAGTGAGACTGAGATGAAAAGAAATAACCTACAGAGTGGTCTGTAATGCCTTTTGGTTGGACTGGGAACAAGT
AAAAATTTCTAATAAACATTTTGAGACTTCCAGAATCACTTTTGTTATCTTATCAGACCATGGGCCTGCTGAGGGTTGAGCAGACAGCCT
GCATTCTAACATACCCTGTTCCCACCCCACGGCCATTCAGACTGCACTCAATACGCTGAAGTCGCTTTTGTTGTTGTTGTTGTTGTTTGC
ATCATTTGGATTTTTTTCCTGCTTTCAATACCAAAAAAATGCAGATGCTTTAAGGCCTAAACAGAATTCTGAAGAATTTAAAATATGCAA
TTAAAGTTTGATATGTTTTGTCTCCCAAGCACCTTGTTTTTTGTTGTTGTTGTTGTTGTTGAAGTCAGCTGATTTTCTCTTTAGAAAGAG
GGTCAGCTAGAAACCTAGGTTTTTTGGAATTGTAAATTTTTTTTTAGTATAGTCTGGAGAGAAAGGTCATTCAAAAGGAAAGTACAATGG
GACTTGCTGCCCTTCATCATCTCGTTCCCGTGCCAGGTGTGTGTTGGTCACGTAAAAGCCTGGGAAGCATCAGAGGAGTCCCGGATTGCT
GCTGCTACCTGGAGACAGGGTTAGCAAAATAACACTAGTGATGAGGGAGAGGCTTCTTTTCACCATAAGCCTGCTGTGTACACCGAGGGC
GGCAGGAGAAGCATGGGAAGGAGTCAGCCTAAGTTTGCACATTGCATAAAGGGTACACTAAGGTATGAGCTGAAGCTTTAGGTTCTCCGT
GCTTCCCTCAAGACCTCCTTCTTGCTAACAGAAGCAGTAGGCAATTGCTGCAGTGCGTTTCTCACCCTGCCAATAGGTCTGTCTGTATCT
CTGTTAAGGAAAATAGCCTGGTCCCTCCTGGCAGTGCTTGGAAGCTTGATGCTAATTTTTATATAGCGTGGCAAACTGACCAGCAGTGCC
AGGCCTTGATCTGTATTCTGCACTATCCCTTTACTTGGTTCCTGGCACTGAATGGTCTCCAGCCCTGAAGAATCACGTGTGATCACAGCA
GCTGACCTGGGCTTTCTCCCCGAGAGGAAGGGGCATGTCATTTTTATTTGACAGAGGGAAAATGGGAGCTGTCCTTGACTGCCTTTGTTG
TGCTTTCCCGCGTAAGATAGCACTGTGTTTTAAACTGTTGCATTACACTGTCTTTGCAATGATGTAAATGTAAGAAATCACTTAGCTTTA
AAAGCGCAGTGGTTTGATCTTATTTATATGAAGACTTTTTAACATATCAAGAATTAGGTGCATTGGCAGGTAGGGTTTGGGGTGTGATAA
CTGCTTCAGATGGAATGTTCACTTAAGCTTTGTCTTCTTAAAAATTATCAATGTGAATGTCATAATTATATATATTTTTGTGGAAAATTT
TCTCCTAAGTATAAGTTATTGTGCAAAATATAGTGTCATTGATGCAAATAATAGTTTAACTTTTAGTTTAGAACTCCTAAAAGATATAAA
TTGTATTGCATATGCATTAAAAGTTTGTTTTATTTAATTTTATGTAGATGTGTGAAGTGTTAGGTAAAATTTTTTTCACTTATCCATTTA
AACACCTTGTTACTTGAATATTGTGTTGACTGGTCTGCAACAGTGATCCATTCTGTAATATAGCTCTTTTAACTGGGAAGGAACCACACC
CCAGTTGTGCCGATTACATTAGTGTTGGCACACAGTCGGGTGCTAGTGTAACACAAATGCCGCGTTGTCTGGGTGTACAGTGTTTGTGGA
GACGCCACTTCCTCAAAATGGTTTTTGATTGTTTTTAACCTATAAGACGTTCTGATGCTCACAAACCTCTATTCAACACACAAAACAAAC
ATGAAAAGGTAGTTAGTTGGGTTGTAACAGCTTACTGGGGTGGACTCATAAAACAGTGGCTTTCTGTTCATCTAAAGTTTCCTCAGATAC
CACAGACCACTGTTAAGTGTGCTCATTGTCACTTTAAATTTCAACGATACCCTATTTTTGTCATTCTAAATATCAGATGTACTATTGGTA
TAATTGCACACCAAAAATAAGCCAAACAGTGCATTACGCTAACTGGATCCCTGCTTTTATGTGAGCTAAGGAAAGATGGAGCCAACTCCA
ACGAGGGCCTCTTTTTCTCTCTTGTCTAGCCTGTTTCTAAACCGAATGATCCAGGATTCAAGCTTCTATTGTCAAGTGAAACTTTCCTCA
GATGGACTCCAGGTAGCCAGGTCACCTAAACCTAGTGGTCCTGTGCGATGCTCTTTCTGCCAGTCCCTGAATCTCTGCAGCTTCTCTTAC
CTGTCTTACCTGTAGTAAAGCACAATTGCAGTGGCGTCGCATTCAGAAGAAGGGAAGGTCAGCAGAGGCTATGCATGTTGTGTGATGATG
AGTGTTTACAGCCACCTTCTCCTAAAACGAAATTTATACCGGGGTGGATAGTATTCCATTAGGTAGACTTATCGACTTTGCTAAGTGCTT
TTTAGACAGCTTAAAAAATTTTCAAGATTTTAAAAGATGTATAAGGTTAAGTTTGCAAATATAATGGAAATGCTGTATATCTTTTGAAGT
GATGAAATCCACGTTGGAATTTTAAAGAAAATATGTTGTAATAATGCTGTTGTAAGTAATATTTTAATGTCTCTTTGCCTGTTTTCTATT
TCAGCACATTCATTGTGGTGAATGTTCATAGCATTATAACTGCTTAGCCATTGAATGATAACATTTGTTAGTGGAAATTGGAAAATTTAT
TTGTGAAATTCTGCAGAATTCATTTTTCTATTTCCAATATTTGCTGAGGTTAAATAAAAATTTTCAAGCCATTGATGTAATAAAATATGA

>99632_99632_1_XPC-RCOR1_XPC_chr3_14209757_ENST00000285021_RCOR1_chr14_103177272_ENST00000262241_length(amino acids)=404AA_BP=178
MARKRAAGGEPRGRELRSQKSKAKSKARREEEEEDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKD
EALSDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSE
DELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQ
IQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWE

--------------------------------------------------------------
>99632_99632_2_XPC-RCOR1_XPC_chr3_14209757_ENST00000285021_RCOR1_chr14_103177272_ENST00000570597_length(transcript)=5499nt_BP=751nt
ATACACCGGAAATAGAGAGAAACCTGTTGTGCTCTTTCCTGCTTCCCGCAGTTTTTTAGTGGCCACGGGTATGGGGTGGAGCTTCCTTTA
GGGGCGTGACTAGGCCTCCAACGAAGGGGCGTGGCCAAGCGCACCGCCTCGGGGCGGGGCCGGCGTTCTAGCGCATCGCGGCCGGGTGCG
TCACTCGCGAAGTGGAATTTGCCCAGACAAGCAACATGGCTCGGAAACGCGCGGCCGGCGGGGAGCCGCGGGGACGCGAACTGCGCAGCC
AGAAATCCAAGGCCAAGAGCAAGGCCCGGCGTGAGGAGGAGGAGGAGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCT
CCAAAGTTTCACAAGGAAAGAGGAAAAGAGGCTGCAGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGA
CTGTTAAATCTGAAAACCTCAAGGTTATAAAGGATGAAGCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGG
CACACCATCTGAAGAGAGGGGCTACCATGAATGAAGACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGTTGAAGAAC
TTAGTGAGCCTGTGCTGGGTGACGTGAGAGAAAGTACAGCCTTCTCTCGATCTCTTCTGCCTGTGAAGCCAGTGGAGATAGAGATTGAAA
CGCCAGAGCAGGCGAAGACAAGAGAAAGAAGCGAGGATGAACTGGAAGAGGCAAATGGAAACAATCCCATTGACATTGAGGTTGATCAAA
ACAAGGAAAGCAAAAAGGAGGTTCCCCCTACTGAGACAGTTCCTCAGGTCAAAAAAGAAAAACATAGCACACAAGCTAAAAATAGAGCAA
AAAGGAAACCTCCAAAAGGAATGTTTCTTTCTCAAGAAGATGTGGAGGCTGTTTCTGCCAATGCCACTGCTGCTACCACGGTGCTGAGAC
AACTAGACATGGAATTGGTTTCAGTCAAACGACAGATCCAGAATATTAAACAGACAAACAGTGCTCTCAAAGAAAAACTTGATGGTGGAA
TAGAACCATATCGACTTCCAGAGGTCATTCAGAAATGTAATGCACGTTGGACTACAGAAGAGCAGCTTCTCGCCGTACAAGCCATCAGGA
AATATGGCCGAGATTTTCAGGCAATCTCAGACGTGATTGGGAACAAATCAGTGGTACAAGTGAAAAACTTTTTTGTAAATTATCGACGCC
GCTTCAACATAGATGAAGTTTTACAAGAATGGGAGGCAGAACATGGTAAAGAAGAGACCAATGGGCCCAGTAACCAGAAGCCTGTGAAGT
CCCCAGATAATTCCATTAAGATGCCCGAAGAGGAAGACGAGGCTCCTGTTCTGGATGTCAGATATGCATCTGCCTCCTGAGAAACTGGTG
GCTTTGAACACTTGGTGTGGACTACTGTGTTATCCGGGATATCAGGTATTATGAGACATCACCTAGCCATCTGCATCACATCTCTCTGGA
CAAGCAGCTATTACCAAAAAAGGCATATACTTCCAGTCCTGTGCTCCATCTGCCTTAATTCTTTGCTCGTTCCTCCATGTTGGCGCCACT
TCCCAGAGAGCTCCACTGCATCTCACACTCTGCCCACGTGCTGGGGAAGTCTCACGGCCTGCACATCTCTTGTGACTCTGGGAACCGCCT
CTCCCGCCGGAGCCCCCGAGCCCCACCAATGGCAGCTCTTCCCAGTCAGCAGCTTCAGAGCAGGCAGTCTCCTTGGAAGGCCCGACTCTG
TTCCTGCATGGCCTGCAGTTTCTACTTTGTGCATAGAGTCATTTTCAGAGTCACCGCGACCCTGTTGGCCTTCTAGAAAGTTTCTTTTGT
TCTTTTCTGAGACAACCACCTAAGTGATAATACGCTTTTTTGGAAACTAATATATATTGCCAGACTGCATCATAACCTTTATCATGCCAA
GCATCCTGATGCAACTCACATTTCCCTAAACATGGGGTACAGTTATGATTTATAAATTGAGTTGGCTTAAATCTCCCTCTTCTCCCTTCC
CAAGTGTTACAAAGATCATTTACTGCAACTGTCGTTGGACACTGTAGCTTAAAGGGAACGTGGACCTCAATGCTTTCTGCCTTCAACTTT
TCAGCATTGTGACCCCAGGGTGGTTGCCACCCCATCTTTTCCTGACCCCCCCCACCCCCCCACCTCCAAGAGGTTCGGCCCACATCACTG
TACCTGGTGCTTGTAAATTTGGAATTGGTGCCTTCTCCTTTTGGCAACCATGGTTATCAATCCTTTTTCTGTTTTAGTGTCTTATTTCTT
CTTTCAAGTTATTTGCTAGCCAAAGATGACATCACTGAGATTAGGAGACAGGGGAGAGCTTGCTGCAGATTCTGACAGTGCAGATTTTAA
ATGTCAGGATATTAGAATAGCTGGCGCTGGTTTATGAAAGCTGCGCGTTGTTCCGCGTTCTCTCGGTGTGCCTGGCCTTTTATGTGGCAC
TCTGTATGTCAGTTTGTGTCCTTCATGTGCTGATGTGATTACACAAACACCATGCACTCTCTTTTCATATCAGAGTACAGGACAGAGAAG
TGATCAATGTATTGGTCTAGTGAGACTGAGATGAAAAGAAATAACCTACAGAGTGGTCTGTAATGCCTTTTGGTTGGACTGGGAACAAGT
AAAAATTTCTAATAAACATTTTGAGACTTCCAGAATCACTTTTGTTATCTTATCAGACCATGGGCCTGCTGAGGGTTGAGCAGACAGCCT
GCATTCTAACATACCCTGTTCCCACCCCACGGCCATTCAGACTGCACTCAATACGCTGAAGTCGCTTTTGTTGTTGTTGTTGTTGTTTGC
ATCATTTGGATTTTTTTCCTGCTTTCAATACCAAAAAAATGCAGATGCTTTAAGGCCTAAACAGAATTCTGAAGAATTTAAAATATGCAA
TTAAAGTTTGATATGTTTTGTCTCCCAAGCACCTTGTTTTTTGTTGTTGTTGTTGTTGTTGAAGTCAGCTGATTTTCTCTTTAGAAAGAG
GGTCAGCTAGAAACCTAGGTTTTTTGGAATTGTAAATTTTTTTTTAGTATAGTCTGGAGAGAAAGGTCATTCAAAAGGAAAGTACAATGG
GACTTGCTGCCCTTCATCATCTCGTTCCCGTGCCAGGTGTGTGTTGGTCACGTAAAAGCCTGGGAAGCATCAGAGGAGTCCCGGATTGCT
GCTGCTACCTGGAGACAGGGTTAGCAAAATAACACTAGTGATGAGGGAGAGGCTTCTTTTCACCATAAGCCTGCTGTGTACACCGAGGGC
GGCAGGAGAAGCATGGGAAGGAGTCAGCCTAAGTTTGCACATTGCATAAAGGGTACACTAAGGTATGAGCTGAAGCTTTAGGTTCTCCGT
GCTTCCCTCAAGACCTCCTTCTTGCTAACAGAAGCAGTAGGCAATTGCTGCAGTGCGTTTCTCACCCTGCCAATAGGTCTGTCTGTATCT
CTGTTAAGGAAAATAGCCTGGTCCCTCCTGGCAGTGCTTGGAAGCTTGATGCTAATTTTTATATAGCGTGGCAAACTGACCAGCAGTGCC
AGGCCTTGATCTGTATTCTGCACTATCCCTTTACTTGGTTCCTGGCACTGAATGGTCTCCAGCCCTGAAGAATCACGTGTGATCACAGCA
GCTGACCTGGGCTTTCTCCCCGAGAGGAAGGGGCATGTCATTTTTATTTGACAGAGGGAAAATGGGAGCTGTCCTTGACTGCCTTTGTTG
TGCTTTCCCGCGTAAGATAGCACTGTGTTTTAAACTGTTGCATTACACTGTCTTTGCAATGATGTAAATGTAAGAAATCACTTAGCTTTA
AAAGCGCAGTGGTTTGATCTTATTTATATGAAGACTTTTTAACATATCAAGAATTAGGTGCATTGGCAGGTAGGGTTTGGGGTGTGATAA
CTGCTTCAGATGGAATGTTCACTTAAGCTTTGTCTTCTTAAAAATTATCAATGTGAATGTCATAATTATATATATTTTTGTGGAAAATTT
TCTCCTAAGTATAAGTTATTGTGCAAAATATAGTGTCATTGATGCAAATAATAGTTTAACTTTTAGTTTAGAACTCCTAAAAGATATAAA
TTGTATTGCATATGCATTAAAAGTTTGTTTTATTTAATTTTATGTAGATGTGTGAAGTGTTAGGTAAAATTTTTTTCACTTATCCATTTA
AACACCTTGTTACTTGAATATTGTGTTGACTGGTCTGCAACAGTGATCCATTCTGTAATATAGCTCTTTTAACTGGGAAGGAACCACACC
CCAGTTGTGCCGATTACATTAGTGTTGGCACACAGTCGGGTGCTAGTGTAACACAAATGCCGCGTTGTCTGGGTGTACAGTGTTTGTGGA
GACGCCACTTCCTCAAAATGGTTTTTGATTGTTTTTAACCTATAAGACGTTCTGATGCTCACAAACCTCTATTCAACACACAAAACAAAC
ATGAAAAGGTAGTTAGTTGGGTTGTAACAGCTTACTGGGGTGGACTCATAAAACAGTGGCTTTCTGTTCATCTAAAGTTTCCTCAGATAC
CACAGACCACTGTTAAGTGTGCTCATTGTCACTTTAAATTTCAACGATACCCTATTTTTGTCATTCTAAATATCAGATGTACTATTGGTA
TAATTGCACACCAAAAATAAGCCAAACAGTGCATTACGCTAACTGGATCCCTGCTTTTATGTGAGCTAAGGAAAGATGGAGCCAACTCCA
ACGAGGGCCTCTTTTTCTCTCTTGTCTAGCCTGTTTCTAAACCGAATGATCCAGGATTCAAGCTTCTATTGTCAAGTGAAACTTTCCTCA
GATGGACTCCAGGTAGCCAGGTCACCTAAACCTAGTGGTCCTGTGCGATGCTCTTTCTGCCAGTCCCTGAATCTCTGCAGCTTCTCTTAC
CTGTCTTACCTGTAGTAAAGCACAATTGCAGTGGCGTCGCATTCAGAAGAAGGGAAGGTCAGCAGAGGCTATGCATGTTGTGTGATGATG
AGTGTTTACAGCCACCTTCTCCTAAAACGAAATTTATACCGGGGTGGATAGTATTCCATTAGGTAGACTTATCGACTTTGCTAAGTGCTT
TTTAGACAGCTTAAAAAATTTTCAAGATTTTAAAAGATGTATAAGGTTAAGTTTGCAAATATAATGGAAATGCTGTATATCTTTTGAAGT
GATGAAATCCACGTTGGAATTTTAAAGAAAATATGTTGTAATAATGCTGTTGTAAGTAATATTTTAATGTCTCTTTGCCTGTTTTCTATT
TCAGCACATTCATTGTGGTGAATGTTCATAGCATTATAACTGCTTAGCCATTGAATGATAACATTTGTTAGTGGAAATTGGAAAATTTAT
TTGTGAAATTCTGCAGAATTCATTTTTCTATTTCCAATATTTGCTGAGGTTAAATAAAAATTTTCAAGCCATTGATGTAATAAAATATGA

>99632_99632_2_XPC-RCOR1_XPC_chr3_14209757_ENST00000285021_RCOR1_chr14_103177272_ENST00000570597_length(amino acids)=404AA_BP=178
MARKRAAGGEPRGRELRSQKSKAKSKARREEEEEDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKD
EALSDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSE
DELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQ
IQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWE

--------------------------------------------------------------
>99632_99632_3_XPC-RCOR1_XPC_chr3_14209757_ENST00000449060_RCOR1_chr14_103177272_ENST00000262241_length(transcript)=5174nt_BP=425nt
ATGGCTCGGAAACGCGCGGCCGGCGGGGAGCCGCGGGGACGCGAACTGCGCAGCCAGAAATCCAAGGCCAAGAGCAAGGCCCGGCGTGAG
GAGGAGGAGGAGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAGGAAAAGAGGCTGC
AGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAAGGTTATAAAGGAT
GAAGCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGCTACCATGAATGAA
GACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGCGAAGACAAGAGAAAGAAGCGAGGATGAACTGGAAGAGGCAAAT
GGAAACAATCCCATTGACATTGAGGTTGATCAAAACAAGGAAAGCAAAAAGGAGGTTCCCCCTACTGAGACAGTTCCTCAGGTCAAAAAA
GAAAAACATAGCACACAAGCTAAAAATAGAGCAAAAAGGAAACCTCCAAAAGGAATGTTTCTTTCTCAAGAAGATGTGGAGGCTGTTTCT
GCCAATGCCACTGCTGCTACCACGGTGCTGAGACAACTAGACATGGAATTGGTTTCAGTCAAACGACAGATCCAGAATATTAAACAGACA
AACAGTGCTCTCAAAGAAAAACTTGATGGTGGAATAGAACCATATCGACTTCCAGAGGTCATTCAGAAATGTAATGCACGTTGGACTACA
GAAGAGCAGCTTCTCGCCGTACAAGCCATCAGGAAATATGGCCGAGATTTTCAGGCAATCTCAGACGTGATTGGGAACAAATCAGTGGTA
CAAGTGAAAAACTTTTTTGTAAATTATCGACGCCGCTTCAACATAGATGAAGTTTTACAAGAATGGGAGGCAGAACATGGTAAAGAAGAG
ACCAATGGGCCCAGTAACCAGAAGCCTGTGAAGTCCCCAGATAATTCCATTAAGATGCCCGAAGAGGAAGACGAGGCTCCTGTTCTGGAT
GTCAGATATGCATCTGCCTCCTGAGAAACTGGTGGCTTTGAACACTTGGTGTGGACTACTGTGTTATCCGGGATATCAGGTATTATGAGA
CATCACCTAGCCATCTGCATCACATCTCTCTGGACAAGCAGCTATTACCAAAAAAGGCATATACTTCCAGTCCTGTGCTCCATCTGCCTT
AATTCTTTGCTCGTTCCTCCATGTTGGCGCCACTTCCCAGAGAGCTCCACTGCATCTCACACTCTGCCCACGTGCTGGGGAAGTCTCACG
GCCTGCACATCTCTTGTGACTCTGGGAACCGCCTCTCCCGCCGGAGCCCCCGAGCCCCACCAATGGCAGCTCTTCCCAGTCAGCAGCTTC
AGAGCAGGCAGTCTCCTTGGAAGGCCCGACTCTGTTCCTGCATGGCCTGCAGTTTCTACTTTGTGCATAGAGTCATTTTCAGAGTCACCG
CGACCCTGTTGGCCTTCTAGAAAGTTTCTTTTGTTCTTTTCTGAGACAACCACCTAAGTGATAATACGCTTTTTTGGAAACTAATATATA
TTGCCAGACTGCATCATAACCTTTATCATGCCAAGCATCCTGATGCAACTCACATTTCCCTAAACATGGGGTACAGTTATGATTTATAAA
TTGAGTTGGCTTAAATCTCCCTCTTCTCCCTTCCCAAGTGTTACAAAGATCATTTACTGCAACTGTCGTTGGACACTGTAGCTTAAAGGG
AACGTGGACCTCAATGCTTTCTGCCTTCAACTTTTCAGCATTGTGACCCCAGGGTGGTTGCCACCCCATCTTTTCCTGACCCCCCCCACC
CCCCCACCTCCAAGAGGTTCGGCCCACATCACTGTACCTGGTGCTTGTAAATTTGGAATTGGTGCCTTCTCCTTTTGGCAACCATGGTTA
TCAATCCTTTTTCTGTTTTAGTGTCTTATTTCTTCTTTCAAGTTATTTGCTAGCCAAAGATGACATCACTGAGATTAGGAGACAGGGGAG
AGCTTGCTGCAGATTCTGACAGTGCAGATTTTAAATGTCAGGATATTAGAATAGCTGGCGCTGGTTTATGAAAGCTGCGCGTTGTTCCGC
GTTCTCTCGGTGTGCCTGGCCTTTTATGTGGCACTCTGTATGTCAGTTTGTGTCCTTCATGTGCTGATGTGATTACACAAACACCATGCA
CTCTCTTTTCATATCAGAGTACAGGACAGAGAAGTGATCAATGTATTGGTCTAGTGAGACTGAGATGAAAAGAAATAACCTACAGAGTGG
TCTGTAATGCCTTTTGGTTGGACTGGGAACAAGTAAAAATTTCTAATAAACATTTTGAGACTTCCAGAATCACTTTTGTTATCTTATCAG
ACCATGGGCCTGCTGAGGGTTGAGCAGACAGCCTGCATTCTAACATACCCTGTTCCCACCCCACGGCCATTCAGACTGCACTCAATACGC
TGAAGTCGCTTTTGTTGTTGTTGTTGTTGTTTGCATCATTTGGATTTTTTTCCTGCTTTCAATACCAAAAAAATGCAGATGCTTTAAGGC
CTAAACAGAATTCTGAAGAATTTAAAATATGCAATTAAAGTTTGATATGTTTTGTCTCCCAAGCACCTTGTTTTTTGTTGTTGTTGTTGT
TGTTGAAGTCAGCTGATTTTCTCTTTAGAAAGAGGGTCAGCTAGAAACCTAGGTTTTTTGGAATTGTAAATTTTTTTTTAGTATAGTCTG
GAGAGAAAGGTCATTCAAAAGGAAAGTACAATGGGACTTGCTGCCCTTCATCATCTCGTTCCCGTGCCAGGTGTGTGTTGGTCACGTAAA
AGCCTGGGAAGCATCAGAGGAGTCCCGGATTGCTGCTGCTACCTGGAGACAGGGTTAGCAAAATAACACTAGTGATGAGGGAGAGGCTTC
TTTTCACCATAAGCCTGCTGTGTACACCGAGGGCGGCAGGAGAAGCATGGGAAGGAGTCAGCCTAAGTTTGCACATTGCATAAAGGGTAC
ACTAAGGTATGAGCTGAAGCTTTAGGTTCTCCGTGCTTCCCTCAAGACCTCCTTCTTGCTAACAGAAGCAGTAGGCAATTGCTGCAGTGC
GTTTCTCACCCTGCCAATAGGTCTGTCTGTATCTCTGTTAAGGAAAATAGCCTGGTCCCTCCTGGCAGTGCTTGGAAGCTTGATGCTAAT
TTTTATATAGCGTGGCAAACTGACCAGCAGTGCCAGGCCTTGATCTGTATTCTGCACTATCCCTTTACTTGGTTCCTGGCACTGAATGGT
CTCCAGCCCTGAAGAATCACGTGTGATCACAGCAGCTGACCTGGGCTTTCTCCCCGAGAGGAAGGGGCATGTCATTTTTATTTGACAGAG
GGAAAATGGGAGCTGTCCTTGACTGCCTTTGTTGTGCTTTCCCGCGTAAGATAGCACTGTGTTTTAAACTGTTGCATTACACTGTCTTTG
CAATGATGTAAATGTAAGAAATCACTTAGCTTTAAAAGCGCAGTGGTTTGATCTTATTTATATGAAGACTTTTTAACATATCAAGAATTA
GGTGCATTGGCAGGTAGGGTTTGGGGTGTGATAACTGCTTCAGATGGAATGTTCACTTAAGCTTTGTCTTCTTAAAAATTATCAATGTGA
ATGTCATAATTATATATATTTTTGTGGAAAATTTTCTCCTAAGTATAAGTTATTGTGCAAAATATAGTGTCATTGATGCAAATAATAGTT
TAACTTTTAGTTTAGAACTCCTAAAAGATATAAATTGTATTGCATATGCATTAAAAGTTTGTTTTATTTAATTTTATGTAGATGTGTGAA
GTGTTAGGTAAAATTTTTTTCACTTATCCATTTAAACACCTTGTTACTTGAATATTGTGTTGACTGGTCTGCAACAGTGATCCATTCTGT
AATATAGCTCTTTTAACTGGGAAGGAACCACACCCCAGTTGTGCCGATTACATTAGTGTTGGCACACAGTCGGGTGCTAGTGTAACACAA
ATGCCGCGTTGTCTGGGTGTACAGTGTTTGTGGAGACGCCACTTCCTCAAAATGGTTTTTGATTGTTTTTAACCTATAAGACGTTCTGAT
GCTCACAAACCTCTATTCAACACACAAAACAAACATGAAAAGGTAGTTAGTTGGGTTGTAACAGCTTACTGGGGTGGACTCATAAAACAG
TGGCTTTCTGTTCATCTAAAGTTTCCTCAGATACCACAGACCACTGTTAAGTGTGCTCATTGTCACTTTAAATTTCAACGATACCCTATT
TTTGTCATTCTAAATATCAGATGTACTATTGGTATAATTGCACACCAAAAATAAGCCAAACAGTGCATTACGCTAACTGGATCCCTGCTT
TTATGTGAGCTAAGGAAAGATGGAGCCAACTCCAACGAGGGCCTCTTTTTCTCTCTTGTCTAGCCTGTTTCTAAACCGAATGATCCAGGA
TTCAAGCTTCTATTGTCAAGTGAAACTTTCCTCAGATGGACTCCAGGTAGCCAGGTCACCTAAACCTAGTGGTCCTGTGCGATGCTCTTT
CTGCCAGTCCCTGAATCTCTGCAGCTTCTCTTACCTGTCTTACCTGTAGTAAAGCACAATTGCAGTGGCGTCGCATTCAGAAGAAGGGAA
GGTCAGCAGAGGCTATGCATGTTGTGTGATGATGAGTGTTTACAGCCACCTTCTCCTAAAACGAAATTTATACCGGGGTGGATAGTATTC
CATTAGGTAGACTTATCGACTTTGCTAAGTGCTTTTTAGACAGCTTAAAAAATTTTCAAGATTTTAAAAGATGTATAAGGTTAAGTTTGC
AAATATAATGGAAATGCTGTATATCTTTTGAAGTGATGAAATCCACGTTGGAATTTTAAAGAAAATATGTTGTAATAATGCTGTTGTAAG
TAATATTTTAATGTCTCTTTGCCTGTTTTCTATTTCAGCACATTCATTGTGGTGAATGTTCATAGCATTATAACTGCTTAGCCATTGAAT
GATAACATTTGTTAGTGGAAATTGGAAAATTTATTTGTGAAATTCTGCAGAATTCATTTTTCTATTTCCAATATTTGCTGAGGTTAAATA

>99632_99632_3_XPC-RCOR1_XPC_chr3_14209757_ENST00000449060_RCOR1_chr14_103177272_ENST00000262241_length(amino acids)=367AA_BP=141
MARKRAAGGEPRGRELRSQKSKAKSKARREEEEEDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKD
EALSDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEAKTRERSEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKK
EKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTT
EEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLD

--------------------------------------------------------------
>99632_99632_4_XPC-RCOR1_XPC_chr3_14209757_ENST00000449060_RCOR1_chr14_103177272_ENST00000570597_length(transcript)=5173nt_BP=425nt
ATGGCTCGGAAACGCGCGGCCGGCGGGGAGCCGCGGGGACGCGAACTGCGCAGCCAGAAATCCAAGGCCAAGAGCAAGGCCCGGCGTGAG
GAGGAGGAGGAGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAGGAAAAGAGGCTGC
AGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAAGGTTATAAAGGAT
GAAGCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGCTACCATGAATGAA
GACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGCGAAGACAAGAGAAAGAAGCGAGGATGAACTGGAAGAGGCAAAT
GGAAACAATCCCATTGACATTGAGGTTGATCAAAACAAGGAAAGCAAAAAGGAGGTTCCCCCTACTGAGACAGTTCCTCAGGTCAAAAAA
GAAAAACATAGCACACAAGCTAAAAATAGAGCAAAAAGGAAACCTCCAAAAGGAATGTTTCTTTCTCAAGAAGATGTGGAGGCTGTTTCT
GCCAATGCCACTGCTGCTACCACGGTGCTGAGACAACTAGACATGGAATTGGTTTCAGTCAAACGACAGATCCAGAATATTAAACAGACA
AACAGTGCTCTCAAAGAAAAACTTGATGGTGGAATAGAACCATATCGACTTCCAGAGGTCATTCAGAAATGTAATGCACGTTGGACTACA
GAAGAGCAGCTTCTCGCCGTACAAGCCATCAGGAAATATGGCCGAGATTTTCAGGCAATCTCAGACGTGATTGGGAACAAATCAGTGGTA
CAAGTGAAAAACTTTTTTGTAAATTATCGACGCCGCTTCAACATAGATGAAGTTTTACAAGAATGGGAGGCAGAACATGGTAAAGAAGAG
ACCAATGGGCCCAGTAACCAGAAGCCTGTGAAGTCCCCAGATAATTCCATTAAGATGCCCGAAGAGGAAGACGAGGCTCCTGTTCTGGAT
GTCAGATATGCATCTGCCTCCTGAGAAACTGGTGGCTTTGAACACTTGGTGTGGACTACTGTGTTATCCGGGATATCAGGTATTATGAGA
CATCACCTAGCCATCTGCATCACATCTCTCTGGACAAGCAGCTATTACCAAAAAAGGCATATACTTCCAGTCCTGTGCTCCATCTGCCTT
AATTCTTTGCTCGTTCCTCCATGTTGGCGCCACTTCCCAGAGAGCTCCACTGCATCTCACACTCTGCCCACGTGCTGGGGAAGTCTCACG
GCCTGCACATCTCTTGTGACTCTGGGAACCGCCTCTCCCGCCGGAGCCCCCGAGCCCCACCAATGGCAGCTCTTCCCAGTCAGCAGCTTC
AGAGCAGGCAGTCTCCTTGGAAGGCCCGACTCTGTTCCTGCATGGCCTGCAGTTTCTACTTTGTGCATAGAGTCATTTTCAGAGTCACCG
CGACCCTGTTGGCCTTCTAGAAAGTTTCTTTTGTTCTTTTCTGAGACAACCACCTAAGTGATAATACGCTTTTTTGGAAACTAATATATA
TTGCCAGACTGCATCATAACCTTTATCATGCCAAGCATCCTGATGCAACTCACATTTCCCTAAACATGGGGTACAGTTATGATTTATAAA
TTGAGTTGGCTTAAATCTCCCTCTTCTCCCTTCCCAAGTGTTACAAAGATCATTTACTGCAACTGTCGTTGGACACTGTAGCTTAAAGGG
AACGTGGACCTCAATGCTTTCTGCCTTCAACTTTTCAGCATTGTGACCCCAGGGTGGTTGCCACCCCATCTTTTCCTGACCCCCCCCACC
CCCCCACCTCCAAGAGGTTCGGCCCACATCACTGTACCTGGTGCTTGTAAATTTGGAATTGGTGCCTTCTCCTTTTGGCAACCATGGTTA
TCAATCCTTTTTCTGTTTTAGTGTCTTATTTCTTCTTTCAAGTTATTTGCTAGCCAAAGATGACATCACTGAGATTAGGAGACAGGGGAG
AGCTTGCTGCAGATTCTGACAGTGCAGATTTTAAATGTCAGGATATTAGAATAGCTGGCGCTGGTTTATGAAAGCTGCGCGTTGTTCCGC
GTTCTCTCGGTGTGCCTGGCCTTTTATGTGGCACTCTGTATGTCAGTTTGTGTCCTTCATGTGCTGATGTGATTACACAAACACCATGCA
CTCTCTTTTCATATCAGAGTACAGGACAGAGAAGTGATCAATGTATTGGTCTAGTGAGACTGAGATGAAAAGAAATAACCTACAGAGTGG
TCTGTAATGCCTTTTGGTTGGACTGGGAACAAGTAAAAATTTCTAATAAACATTTTGAGACTTCCAGAATCACTTTTGTTATCTTATCAG
ACCATGGGCCTGCTGAGGGTTGAGCAGACAGCCTGCATTCTAACATACCCTGTTCCCACCCCACGGCCATTCAGACTGCACTCAATACGC
TGAAGTCGCTTTTGTTGTTGTTGTTGTTGTTTGCATCATTTGGATTTTTTTCCTGCTTTCAATACCAAAAAAATGCAGATGCTTTAAGGC
CTAAACAGAATTCTGAAGAATTTAAAATATGCAATTAAAGTTTGATATGTTTTGTCTCCCAAGCACCTTGTTTTTTGTTGTTGTTGTTGT
TGTTGAAGTCAGCTGATTTTCTCTTTAGAAAGAGGGTCAGCTAGAAACCTAGGTTTTTTGGAATTGTAAATTTTTTTTTAGTATAGTCTG
GAGAGAAAGGTCATTCAAAAGGAAAGTACAATGGGACTTGCTGCCCTTCATCATCTCGTTCCCGTGCCAGGTGTGTGTTGGTCACGTAAA
AGCCTGGGAAGCATCAGAGGAGTCCCGGATTGCTGCTGCTACCTGGAGACAGGGTTAGCAAAATAACACTAGTGATGAGGGAGAGGCTTC
TTTTCACCATAAGCCTGCTGTGTACACCGAGGGCGGCAGGAGAAGCATGGGAAGGAGTCAGCCTAAGTTTGCACATTGCATAAAGGGTAC
ACTAAGGTATGAGCTGAAGCTTTAGGTTCTCCGTGCTTCCCTCAAGACCTCCTTCTTGCTAACAGAAGCAGTAGGCAATTGCTGCAGTGC
GTTTCTCACCCTGCCAATAGGTCTGTCTGTATCTCTGTTAAGGAAAATAGCCTGGTCCCTCCTGGCAGTGCTTGGAAGCTTGATGCTAAT
TTTTATATAGCGTGGCAAACTGACCAGCAGTGCCAGGCCTTGATCTGTATTCTGCACTATCCCTTTACTTGGTTCCTGGCACTGAATGGT
CTCCAGCCCTGAAGAATCACGTGTGATCACAGCAGCTGACCTGGGCTTTCTCCCCGAGAGGAAGGGGCATGTCATTTTTATTTGACAGAG
GGAAAATGGGAGCTGTCCTTGACTGCCTTTGTTGTGCTTTCCCGCGTAAGATAGCACTGTGTTTTAAACTGTTGCATTACACTGTCTTTG
CAATGATGTAAATGTAAGAAATCACTTAGCTTTAAAAGCGCAGTGGTTTGATCTTATTTATATGAAGACTTTTTAACATATCAAGAATTA
GGTGCATTGGCAGGTAGGGTTTGGGGTGTGATAACTGCTTCAGATGGAATGTTCACTTAAGCTTTGTCTTCTTAAAAATTATCAATGTGA
ATGTCATAATTATATATATTTTTGTGGAAAATTTTCTCCTAAGTATAAGTTATTGTGCAAAATATAGTGTCATTGATGCAAATAATAGTT
TAACTTTTAGTTTAGAACTCCTAAAAGATATAAATTGTATTGCATATGCATTAAAAGTTTGTTTTATTTAATTTTATGTAGATGTGTGAA
GTGTTAGGTAAAATTTTTTTCACTTATCCATTTAAACACCTTGTTACTTGAATATTGTGTTGACTGGTCTGCAACAGTGATCCATTCTGT
AATATAGCTCTTTTAACTGGGAAGGAACCACACCCCAGTTGTGCCGATTACATTAGTGTTGGCACACAGTCGGGTGCTAGTGTAACACAA
ATGCCGCGTTGTCTGGGTGTACAGTGTTTGTGGAGACGCCACTTCCTCAAAATGGTTTTTGATTGTTTTTAACCTATAAGACGTTCTGAT
GCTCACAAACCTCTATTCAACACACAAAACAAACATGAAAAGGTAGTTAGTTGGGTTGTAACAGCTTACTGGGGTGGACTCATAAAACAG
TGGCTTTCTGTTCATCTAAAGTTTCCTCAGATACCACAGACCACTGTTAAGTGTGCTCATTGTCACTTTAAATTTCAACGATACCCTATT
TTTGTCATTCTAAATATCAGATGTACTATTGGTATAATTGCACACCAAAAATAAGCCAAACAGTGCATTACGCTAACTGGATCCCTGCTT
TTATGTGAGCTAAGGAAAGATGGAGCCAACTCCAACGAGGGCCTCTTTTTCTCTCTTGTCTAGCCTGTTTCTAAACCGAATGATCCAGGA
TTCAAGCTTCTATTGTCAAGTGAAACTTTCCTCAGATGGACTCCAGGTAGCCAGGTCACCTAAACCTAGTGGTCCTGTGCGATGCTCTTT
CTGCCAGTCCCTGAATCTCTGCAGCTTCTCTTACCTGTCTTACCTGTAGTAAAGCACAATTGCAGTGGCGTCGCATTCAGAAGAAGGGAA
GGTCAGCAGAGGCTATGCATGTTGTGTGATGATGAGTGTTTACAGCCACCTTCTCCTAAAACGAAATTTATACCGGGGTGGATAGTATTC
CATTAGGTAGACTTATCGACTTTGCTAAGTGCTTTTTAGACAGCTTAAAAAATTTTCAAGATTTTAAAAGATGTATAAGGTTAAGTTTGC
AAATATAATGGAAATGCTGTATATCTTTTGAAGTGATGAAATCCACGTTGGAATTTTAAAGAAAATATGTTGTAATAATGCTGTTGTAAG
TAATATTTTAATGTCTCTTTGCCTGTTTTCTATTTCAGCACATTCATTGTGGTGAATGTTCATAGCATTATAACTGCTTAGCCATTGAAT
GATAACATTTGTTAGTGGAAATTGGAAAATTTATTTGTGAAATTCTGCAGAATTCATTTTTCTATTTCCAATATTTGCTGAGGTTAAATA

>99632_99632_4_XPC-RCOR1_XPC_chr3_14209757_ENST00000449060_RCOR1_chr14_103177272_ENST00000570597_length(amino acids)=367AA_BP=141
MARKRAAGGEPRGRELRSQKSKAKSKARREEEEEDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKD
EALSDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEAKTRERSEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKK
EKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTT
EEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for XPC-RCOR1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	RCOR1	chr3:14209757	chr14:103177272	ENST00000570597		5	12	296_384	256.6666666666667	483.0	KDM1A

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	XPC	chr3:14209757	chr14:103177272	ENST00000285021	-	4	16	847_866	178.66666666666666	941.0	CETN2
Hgene	XPC	chr3:14209757	chr14:103177272	ENST00000449060	-	4	16	847_866	141.66666666666666	904.0	CETN2
Hgene	XPC	chr3:14209757	chr14:103177272	ENST00000285021	-	4	16	816_940	178.66666666666666	941.0	ERCC2 and GTF2H1
Hgene	XPC	chr3:14209757	chr14:103177272	ENST00000449060	-	4	16	816_940	141.66666666666666	904.0	ERCC2 and GTF2H1
Hgene	XPC	chr3:14209757	chr14:103177272	ENST00000285021	-	4	16	496_734	178.66666666666666	941.0	RAD23B
Hgene	XPC	chr3:14209757	chr14:103177272	ENST00000449060	-	4	16	496_734	141.66666666666666	904.0	RAD23B
Tgene	RCOR1	chr3:14209757	chr14:103177272	ENST00000570597		5	12	78_257	256.6666666666667	483.0	HDAC1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for XPC-RCOR1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for XPC-RCOR1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source