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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:XPO1-USP34 (FusionGDB2 ID:99668)

Fusion Gene Summary for XPO1-USP34

Fusion gene summary

Fusion gene information	Fusion gene name: XPO1-USP34
	Fusion gene ID: 99668
		Hgene	Tgene
	Gene symbol	XPO1	USP34
	Gene ID	7514	9736
	Gene name	exportin 1	ubiquitin specific peptidase 34
	Synonyms	CRM-1\|CRM1\|emb\|exp1	-
	Cytomap	2p15	2p15
	Type of gene	protein-coding	protein-coding
	Description	exportin-1chromosome region maintenance 1 homologchromosome region maintenance 1 protein homologexportin 1 (CRM1 homolog, yeast)exportin-1 (required for chromosome region maintenance)	ubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34
	Modification date	20200327	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000401558, ENST00000404992, ENST00000406957, ENST00000481214,	ENST00000472689, ENST00000398571,
Fusion gene scores	* DoF score	12 X 15 X 9=1620	10 X 16 X 4=640
	# samples	19	15
	** MAII score	log2(19/1620*10)=-3.09192248944104 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/640*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: XPO1 [Title/Abstract] AND USP34 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	USP34(61597455)-XPO1(61761038), # samples:1 USP34(61632843)-XPO1(61711240), # samples:1 USP34(61697785)-XPO1(61729445), # samples:1 XPO1(61753554)-USP34(61434021), # samples:1 XPO1(61749746)-USP34(61448741), # samples:1 XPO1(61749746)-USP34(61449798), # samples:1 XPO1(61749746)-USP34(61647968), # samples:1 XPO1(61749746)-USP34(61528589), # samples:1
Anticipated loss of major functional domain due to fusion event.	XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. XPO1-USP34 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. USP34-XPO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. USP34-XPO1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. USP34-XPO1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. USP34-XPO1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. USP34-XPO1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	XPO1	GO:0006611	protein export from nucleus	22250199
Tgene	USP34	GO:0016579	protein deubiquitination	14715245
Tgene	USP34	GO:0071108	protein K48-linked deubiquitination	21383061
Tgene	USP34	GO:0090263	positive regulation of canonical Wnt signaling pathway	21383061

Fusion gene breakpoints across XPO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across USP34 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AC-A2BK-01A	XPO1	chr2	61749746	-	USP34	chr2	61647968	-
ChimerDB4	BRCA	TCGA-AC-A8OQ-01A	XPO1	chr2	61749746	-	USP34	chr2	61448741	-
ChimerDB4	BRCA	TCGA-AC-A8OQ-01A	XPO1	chr2	61749746	-	USP34	chr2	61449798	-
ChimerDB4	GBM	TCGA-27-2521-01A	XPO1	chr2	61749746	-	USP34	chr2	61528589	-
ChimerDB4	OV	TCGA-24-1422	XPO1	chr2	61753554	-	USP34	chr2	61434021	-

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Fusion Gene ORF analysis for XPO1-USP34

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000401558	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61448741	-
5CDS-5UTR	ENST00000401558	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61449798	-
5CDS-5UTR	ENST00000404992	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61448741	-
5CDS-5UTR	ENST00000404992	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61449798	-
5CDS-5UTR	ENST00000406957	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61448741	-
5CDS-5UTR	ENST00000406957	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61449798	-
5CDS-intron	ENST00000401558	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61647968	-
5CDS-intron	ENST00000401558	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61528589	-
5CDS-intron	ENST00000401558	ENST00000472689	XPO1	chr2	61753554	-	USP34	chr2	61434021	-
5CDS-intron	ENST00000404992	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61647968	-
5CDS-intron	ENST00000404992	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61528589	-
5CDS-intron	ENST00000404992	ENST00000472689	XPO1	chr2	61753554	-	USP34	chr2	61434021	-
5CDS-intron	ENST00000406957	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61647968	-
5CDS-intron	ENST00000406957	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61528589	-
5CDS-intron	ENST00000406957	ENST00000472689	XPO1	chr2	61753554	-	USP34	chr2	61434021	-
Frame-shift	ENST00000401558	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61647968	-
Frame-shift	ENST00000401558	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61528589	-
Frame-shift	ENST00000401558	ENST00000398571	XPO1	chr2	61753554	-	USP34	chr2	61434021	-
Frame-shift	ENST00000404992	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61647968	-
Frame-shift	ENST00000404992	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61528589	-
Frame-shift	ENST00000404992	ENST00000398571	XPO1	chr2	61753554	-	USP34	chr2	61434021	-
Frame-shift	ENST00000406957	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61647968	-
Frame-shift	ENST00000406957	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61448741	-
Frame-shift	ENST00000406957	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61449798	-
Frame-shift	ENST00000406957	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61528589	-
Frame-shift	ENST00000406957	ENST00000398571	XPO1	chr2	61753554	-	USP34	chr2	61434021	-
In-frame	ENST00000401558	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61448741	-
In-frame	ENST00000401558	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61449798	-
In-frame	ENST00000404992	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61448741	-
In-frame	ENST00000404992	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61449798	-
intron-3CDS	ENST00000481214	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61647968	-
intron-3CDS	ENST00000481214	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61448741	-
intron-3CDS	ENST00000481214	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61449798	-
intron-3CDS	ENST00000481214	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61528589	-
intron-3CDS	ENST00000481214	ENST00000398571	XPO1	chr2	61753554	-	USP34	chr2	61434021	-
intron-5UTR	ENST00000481214	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61448741	-
intron-5UTR	ENST00000481214	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61449798	-
intron-intron	ENST00000481214	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61647968	-
intron-intron	ENST00000481214	ENST00000472689	XPO1	chr2	61749746	-	USP34	chr2	61528589	-
intron-intron	ENST00000481214	ENST00000472689	XPO1	chr2	61753554	-	USP34	chr2	61434021	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000401558	XPO1	chr2	61749746	-	ENST00000398571	USP34	chr2	61448741	-	4515	1029	1050	3875	941
ENST00000404992	XPO1	chr2	61749746	-	ENST00000398571	USP34	chr2	61448741	-	4194	708	729	3554	941
ENST00000401558	XPO1	chr2	61749746	-	ENST00000398571	USP34	chr2	61449798	-	4560	1029	1038	3920	960
ENST00000404992	XPO1	chr2	61749746	-	ENST00000398571	USP34	chr2	61449798	-	4239	708	717	3599	960

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000401558	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61448741	-	0.000341326	0.9996587
ENST00000404992	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61448741	-	0.00026571	0.9997342
ENST00000401558	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61449798	-	0.000240325	0.99975973
ENST00000404992	ENST00000398571	XPO1	chr2	61749746	-	USP34	chr2	61449798	-	0.000205386	0.99979466

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Fusion Genomic Features for XPO1-USP34

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for XPO1-USP34

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:61597455/chr2:61761038)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

46_112

100

1072.0

Domain

Importin N-terminal

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

46_112

100

1072.0

Domain

Importin N-terminal

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

46_112

100

1072.0

Domain

Importin N-terminal

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

46_112

100

1072.0

Domain

Importin N-terminal

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

46_112

100

1072.0

Domain

Importin N-terminal

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

46_112

100

1072.0

Domain

Importin N-terminal

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

1_679

100

1072.0

Region

Note=Necessary for HTLV-1 Rex-mediated mRNA export

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

411_414

100

1072.0

Region

Note=Necessary for HTLV-1 Rex multimerization

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

1_679

100

1072.0

Region

Note=Necessary for HTLV-1 Rex-mediated mRNA export

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

411_414

100

1072.0

Region

Note=Necessary for HTLV-1 Rex multimerization

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

1_679

100

1072.0

Region

Note=Necessary for HTLV-1 Rex-mediated mRNA export

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

411_414

100

1072.0

Region

Note=Necessary for HTLV-1 Rex multimerization

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

1_679

100

1072.0

Region

Note=Necessary for HTLV-1 Rex-mediated mRNA export

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

411_414

100

1072.0

Region

Note=Necessary for HTLV-1 Rex multimerization

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

1_679

100

1072.0

Region

Note=Necessary for HTLV-1 Rex-mediated mRNA export

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

411_414

100

1072.0

Region

Note=Necessary for HTLV-1 Rex multimerization

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

1_679

100

1072.0

Region

Note=Necessary for HTLV-1 Rex-mediated mRNA export

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

411_414

100

1072.0

Region

Note=Necessary for HTLV-1 Rex multimerization

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

1002_1039

100

1072.0

Repeat

Note=HEAT 10

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

217_240

100

1072.0

Repeat

Note=HEAT 1

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

241_277

100

1072.0

Repeat

Note=HEAT 2

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

354_472

100

1072.0

Repeat

Note=HEAT 3

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

515_553

100

1072.0

Repeat

Note=HEAT 4

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

560_597

100

1072.0

Repeat

Note=HEAT 5

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

602_639

100

1072.0

Repeat

Note=HEAT 6

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

775_813

100

1072.0

Repeat

Note=HEAT 7

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

885_916

100

1072.0

Repeat

Note=HEAT 8

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000401558

917_954

100

1072.0

Repeat

Note=HEAT 9

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

1002_1039

100

1072.0

Repeat

Note=HEAT 10

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

217_240

100

1072.0

Repeat

Note=HEAT 1

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

241_277

100

1072.0

Repeat

Note=HEAT 2

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

354_472

100

1072.0

Repeat

Note=HEAT 3

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

515_553

100

1072.0

Repeat

Note=HEAT 4

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

560_597

100

1072.0

Repeat

Note=HEAT 5

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

602_639

100

1072.0

Repeat

Note=HEAT 6

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

775_813

100

1072.0

Repeat

Note=HEAT 7

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

885_916

100

1072.0

Repeat

Note=HEAT 8

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000404992

917_954

100

1072.0

Repeat

Note=HEAT 9

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

1002_1039

100

1072.0

Repeat

Note=HEAT 10

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

217_240

100

1072.0

Repeat

Note=HEAT 1

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

241_277

100

1072.0

Repeat

Note=HEAT 2

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

354_472

100

1072.0

Repeat

Note=HEAT 3

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

515_553

100

1072.0

Repeat

Note=HEAT 4

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

560_597

100

1072.0

Repeat

Note=HEAT 5

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

602_639

100

1072.0

Repeat

Note=HEAT 6

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

775_813

100

1072.0

Repeat

Note=HEAT 7

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

885_916

100

1072.0

Repeat

Note=HEAT 8

Hgene

XPO1

chr2:61749746

chr2:61448741

ENST00000406957

917_954

100

1072.0

Repeat

Note=HEAT 9

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

1002_1039

100

1072.0

Repeat

Note=HEAT 10

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

217_240

100

1072.0

Repeat

Note=HEAT 1

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

241_277

100

1072.0

Repeat

Note=HEAT 2

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

354_472

100

1072.0

Repeat

Note=HEAT 3

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

515_553

100

1072.0

Repeat

Note=HEAT 4

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

560_597

100

1072.0

Repeat

Note=HEAT 5

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

602_639

100

1072.0

Repeat

Note=HEAT 6

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

775_813

100

1072.0

Repeat

Note=HEAT 7

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

885_916

100

1072.0

Repeat

Note=HEAT 8

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000401558

917_954

100

1072.0

Repeat

Note=HEAT 9

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

1002_1039

100

1072.0

Repeat

Note=HEAT 10

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

217_240

100

1072.0

Repeat

Note=HEAT 1

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

241_277

100

1072.0

Repeat

Note=HEAT 2

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

354_472

100

1072.0

Repeat

Note=HEAT 3

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

515_553

100

1072.0

Repeat

Note=HEAT 4

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

560_597

100

1072.0

Repeat

Note=HEAT 5

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

602_639

100

1072.0

Repeat

Note=HEAT 6

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

775_813

100

1072.0

Repeat

Note=HEAT 7

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

885_916

100

1072.0

Repeat

Note=HEAT 8

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000404992

917_954

100

1072.0

Repeat

Note=HEAT 9

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

1002_1039

100

1072.0

Repeat

Note=HEAT 10

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

217_240

100

1072.0

Repeat

Note=HEAT 1

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

241_277

100

1072.0

Repeat

Note=HEAT 2

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

354_472

100

1072.0

Repeat

Note=HEAT 3

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

515_553

100

1072.0

Repeat

Note=HEAT 4

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

560_597

100

1072.0

Repeat

Note=HEAT 5

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

602_639

100

1072.0

Repeat

Note=HEAT 6

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

775_813

100

1072.0

Repeat

Note=HEAT 7

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

885_916

100

1072.0

Repeat

Note=HEAT 8

Hgene

XPO1

chr2:61749746

chr2:61449798

ENST00000406957

917_954

100

1072.0

Repeat

Note=HEAT 9

Tgene

USP34

chr2:61749746

chr2:61448741

ENST00000398571

1894_2239

2598

3547.0

Domain

Note=USP

Tgene

USP34

chr2:61749746

chr2:61449798

ENST00000398571

1894_2239

2583

3547.0

Domain

Note=USP

Top

Fusion Gene Sequence for XPO1-USP34

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>99668_99668_1_XPO1-USP34_XPO1_chr2_61749746_ENST00000401558_USP34_chr2_61448741_ENST00000398571_length(transcript)=4515nt_BP=1029nt
CAACCGGTTCCGAGTTTGAGGCACTAGGAGGAGGGGGAGAAGCGGCTGCAGCGGCCGCGGCAGGAGCAGCGGGAGCTACAGCATCAGCAA
GAGCAACAGTAGCTACAGCCCCGGCGGCGGTGCCTGTTCCAGTCTTTGCTGCTGCAGTCCGTGCAACCACCCAGAGGGGGAGGGGGGAAC
CACCAGTCGCTGAGGAACAAGAGAAGGGGGGAAAGTTTAGGCGAGCCTTGGGGGGGGGGGGGCCAGCGCCGGAGCCGCGTGAGAGAGGGA
GCCGTGTTTTGGTAGGGGGGAGTCGGACTGCAACTGGCAGCAGAGCGTCTCCCCGGCCGTGTGGACTCTACACCCCCTACTCCTGCCGCT
TCTGCTGCTGCCTGTGGCTGGAGGGTCCCCCTGGGGCTGAATCTTTGGGACTTGACCCCGTTCCCTCCCCCTTCCCTCACTCCCCAGCCG
GGCGGGAGCATTTATTCCCCAGATTAATTCCCCTTTTGGGGGGGGGCGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGGGGGAAG
CGTCCCTGAAATAGTAAATATTATTGAGCTCTTTTTGCCCTTTTCCTGTCCGTTTTTTTAATTTCCTTTTTTGAGGTGGGAAAACTGAAA
CCCACCTTGATTCGTCCCCTCTCCCCCCTCCCCACCTTCCCTCGCCCTAATCCCCCAACGAGGAAGGAAGGAGCAGTTGGTTCAATCTCT
GGTAATCTATGCCAGCAATTATGACAATGTTAGCAGACCATGCAGCTCGTCAGCTGCTTGATTTCAGCCAAAAACTGGATATCAACTTAT
TAGATAATGTGGTGAATTGCTTATACCATGGAGAAGGAGCCCAGCAAAGAATGGCTCAAGAAGTACTGACACATTTAAAGGAGCATCCTG
ATGCTTGGACAAGAGTCGACACAATTTTGGAATTTTCTCAGAATATGAATACGAAATACTATGGACTACAAATTTTGGAAAATGTGATAA
AAACAAGGTGGAAGATTCTTCCAAGGAACCAGTGCGAAGGCAGCCAATCCTTTCTTTAAGTTGTTGACTATGCTAATGGAGTTTGCTGGT
GGACCTCCAGGAATGCCTCCCTTTGCATCTTATATTCTGCAGAGGATATGGGAGGTGATTGAATACAATCCTTCTCAGTGTCTAGATTGG
TTGGCAGTGCAGACACCCCGAAATAAACTGGCACACAGCTGGGTCTTACAGAATATGGAAAACTGGGTCGAGCGGTTTCTTTTGGCTCAC
AATTATCCTAGAGTGAGGACTTCTGCAGCTTATCTTCTGGTGTCCCTTATACCAAGCAATTCATTCCGTCAGATGTTCCGGTCAACAAGG
TCTTTGCACATCCCAACCCGTGACCTTCCACTCAGTCCAGACACAACAGTAGTCCTACATCAGGTCTACAACGTGCTCCTTGGTTTGCTC
TCAAGAGCCAAACTTTATGTTGATGCTGCTGTTCATGGCACTACAAAGCTAGTGCCCTATTTTAGCTTTATGACTTACTGTTTAATTTCC
AAAACTGAGAAGCTGATGTTTTCCACATATTTCATGGATTTGTGGAACCTTTTCCAGCCTAAACTTTCTGAGCCAGCAATAGCTACAAAT
CACAATAAACAGGCTTTGCTTTCATTTTGGTACAATGTCTGTGCTGACTGTCCAGAGAATATCCGCCTTATTGTTCAGAACCCAGTGGTA
ACCAAGAACATTGCCTTCAATTACATCCTTGCTGACCATGATGATCAGGATGTGGTGCTTTTTAACCGTGGGATGCTGCCAGCGTACTAT
GGCATTCTGAGGCTCTGCTGTGAGCAGTCTCCTGCATTCACACGACAACTGGCTTCTCACCAGAACATCCAGTGGGCCTTTAAGAATCTT
ACACCACATGCCAGCCAATACCCTGGAGCAGTAGAAGAACTGTTTAACCTGATGCAGCTGTTTATAGCTCAGAGGCCAGATATGAGAGAA
GAAGAATTAGAAGATATTAAACAGTTCAAGAAAACAACCATAAGTTGTTACTTACGTTGCTTAGATGGCCGCTCCTGCTGGACTACTTTA
ATAAGTGCCTTCAGAATACTATTAGAATCTGATGAAGACAGACTTCTTGTTGTATTTAATCGAGGATTGATTCTAATGACAGAGTCTTTC
AACACTTTGCACATGATGTATCACGAAGCTACAGCTTGCCATGTGACTGGAGATTTAGTAGAACTTCTGTCAATATTTCTTTCGGTTTTG
AAGTCTACACGCCCTTATCTTCAGAGAAAAGATGTGAAACAAGCATTAATCCAGTGGCAGGAGCGAATTGAATTTGCCCATAAACTGTTA
ACTCTTCTTAATTCCTATAGTCCTCCAGAACTTAGAAATGCCTGTATAGATGTCCTCAAGGAACTTGTACTTTTGAGTCCCCATGATTTT
CTTCATACTCTGGTTCCCTTTCTACAACACAACCATTGTACTTACCATCACAGTAATATACCAATGTCTCTTGGACCTTATTTCCCTTGT
CGAGAAAATATCAAGCTAATAGGAGGGAAAAGCAATATTCGGCCTCCGCGCCCTGAACTCAATATGTGCCTCTTGCCCACAATGGTGGAA
ACCAGTAAGGGCAAAGATGACGTTTATGATCGTATGCTGCTAGACTACTTCTTTTCTTATCATCAGTTCATCCATCTATTATGCCGAGTT
GCAATCAACTGTGAAAAATTTACTGAAACATTAGTTAAGCTGAGTGTCCTAGTTGCCTATGAAGGTTTGCCACTTCATCTTGCACTGTTC
CCCAAACTTTGGACTGAGCTATGCCAGACTCAGTCTGCTATGTCAAAAAACTGCATCAAGCTTTTGTGTGAAGATCCTGTTTTCGCAGAA
TATATTAAATGTATCCTAATGGATGAAAGAACTTTTTTAAACAACAACATTGTCTACACGTTCATGACACATTTCCTTCTAAAGGTTCAA
AGTCAAGTGTTTTCTGAAGCAAACTGTGCCAATTTGATCAGCACTCTTATTACAAACTTGATAAGCCAGTATCAGAACCTACAGTCTGAT
TTCTCCAACCGAGTTGAAATTTCCAAAGCAAGTGCTTCTTTAAATGGGGACCTGAGGGCACTCGCTTTGCTCCTGTCAGTACACACTCCC
AAACAGTTAAACCCAGCTCTAATTCCAACTCTGCAAGAGCTTTTAAGCAAATGCAGGACTTGTCTGCAACAGAGAAACTCACTCCAAGAG
CAAGAAGCCAAAGAAAGAAAAACTAAAGATGATGAAGGAGCAACTCCCATTAAAAGGCGGCGTGTTAGCAGTGATGAGGAGCACACTGTA
GACAGCTGCATCAGTGACATGAAAACAGAAACCAGGGAGGTCCTGACCCCAACGAGCACTTCTGACAATGAGACCAGAGACTCCTCAATT
ATTGATCCAGGAACTGAGCAAGATCTTCCTTCCCCTGAAAATAGTTCTGTTAAAGAATACCGAATGGAAGTTCCATCTTCGTTTTCAGAA
GACATGTCAAATATCAGGTCACAGCATGCAGAAGAACAGTCCAACAATGGTAGATATGACGATTGTAAAGAATTTAAAGACCTCCACTGT
TCCAAGGATTCTACCCTAGCTGAGGAAGAATCTGAGTTCCCTTCTACTTCTATCTCTGCAGTTCTGTCTGACTTAGCTGACTTGAGAAGC
TGTGATGGCCAAGCTTTGCCCTCCCAGGACCCTGAGGTTGCTTTATCTCTCAGTTGTGGCCATTCCAGAGGACTCTTTAGTCATATGCAG
CAACATGACATTTTAGATACCCTGTGTAGGACCATTGAATCTACAATCCATGTCGTCACAAGGATATCTGGCAAAGGAAACCAAGCTGCT
TCTTGACATTAGGTGTAGCATGTCTACTTTTAAGTCCCTCACCCCCAACCCCCATGCTGTTTGTATAAGTTTTGCTTATTTGTTTTTGTG
CTTCAGTTTGTCCAGTGCTCTCTGCTTGAATGGCAAGATAGATTTATAGGCTTAATTCTTGGTCAGGCAGAACTCCAGATGAAAAAAACT
TGCATCTTCAGTATACTTCCTAAAGGGCAATCAGATAATGGATATGTTTTATGTAATTAAGAGTTCACTTTAGTGGCTTTCATTTAATAT
GGCTGTCTGGGAAGAACAGGGTTGCCTAGCCCTGTACAATGTAATTTAAACTTACAGCATTTTTACTGTGTATGATATGGTGTCCTCTGT
GCCAGTTTTGTACCTTATAGAGGCAGATTGCCTCCGATCGCTGTGGTTCTTATTATCAAAATTAAGTTTACTTGTATACGGAACAACCAC
AAGAAATTTGATTCTGTAAAGAATCCTCTTTAGCTGTGGCCTGGCAGTATATAAATGGTGCTTTATTTAACAGAATACCTGTGGAGGAAA
TAAAGCACACTTGATGTAAAAATAATTGTTTTATTTTTATTGACATGACTGATTGATTGATTGCTATTCTGTGCACTTAATTAAACTGAT

>99668_99668_1_XPO1-USP34_XPO1_chr2_61749746_ENST00000401558_USP34_chr2_61448741_ENST00000398571_length(amino acids)=941AA_BP=
MLTMLMEFAGGPPGMPPFASYILQRIWEVIEYNPSQCLDWLAVQTPRNKLAHSWVLQNMENWVERFLLAHNYPRVRTSAAYLLVSLIPSN
SFRQMFRSTRSLHIPTRDLPLSPDTTVVLHQVYNVLLGLLSRAKLYVDAAVHGTTKLVPYFSFMTYCLISKTEKLMFSTYFMDLWNLFQP
KLSEPAIATNHNKQALLSFWYNVCADCPENIRLIVQNPVVTKNIAFNYILADHDDQDVVLFNRGMLPAYYGILRLCCEQSPAFTRQLASH
QNIQWAFKNLTPHASQYPGAVEELFNLMQLFIAQRPDMREEELEDIKQFKKTTISCYLRCLDGRSCWTTLISAFRILLESDEDRLLVVFN
RGLILMTESFNTLHMMYHEATACHVTGDLVELLSIFLSVLKSTRPYLQRKDVKQALIQWQERIEFAHKLLTLLNSYSPPELRNACIDVLK
ELVLLSPHDFLHTLVPFLQHNHCTYHHSNIPMSLGPYFPCRENIKLIGGKSNIRPPRPELNMCLLPTMVETSKGKDDVYDRMLLDYFFSY
HQFIHLLCRVAINCEKFTETLVKLSVLVAYEGLPLHLALFPKLWTELCQTQSAMSKNCIKLLCEDPVFAEYIKCILMDERTFLNNNIVYT
FMTHFLLKVQSQVFSEANCANLISTLITNLISQYQNLQSDFSNRVEISKASASLNGDLRALALLLSVHTPKQLNPALIPTLQELLSKCRT
CLQQRNSLQEQEAKERKTKDDEGATPIKRRRVSSDEEHTVDSCISDMKTETREVLTPTSTSDNETRDSSIIDPGTEQDLPSPENSSVKEY
RMEVPSSFSEDMSNIRSQHAEEQSNNGRYDDCKEFKDLHCSKDSTLAEEESEFPSTSISAVLSDLADLRSCDGQALPSQDPEVALSLSCG

--------------------------------------------------------------
>99668_99668_2_XPO1-USP34_XPO1_chr2_61749746_ENST00000401558_USP34_chr2_61449798_ENST00000398571_length(transcript)=4560nt_BP=1029nt
CAACCGGTTCCGAGTTTGAGGCACTAGGAGGAGGGGGAGAAGCGGCTGCAGCGGCCGCGGCAGGAGCAGCGGGAGCTACAGCATCAGCAA
GAGCAACAGTAGCTACAGCCCCGGCGGCGGTGCCTGTTCCAGTCTTTGCTGCTGCAGTCCGTGCAACCACCCAGAGGGGGAGGGGGGAAC
CACCAGTCGCTGAGGAACAAGAGAAGGGGGGAAAGTTTAGGCGAGCCTTGGGGGGGGGGGGGCCAGCGCCGGAGCCGCGTGAGAGAGGGA
GCCGTGTTTTGGTAGGGGGGAGTCGGACTGCAACTGGCAGCAGAGCGTCTCCCCGGCCGTGTGGACTCTACACCCCCTACTCCTGCCGCT
TCTGCTGCTGCCTGTGGCTGGAGGGTCCCCCTGGGGCTGAATCTTTGGGACTTGACCCCGTTCCCTCCCCCTTCCCTCACTCCCCAGCCG
GGCGGGAGCATTTATTCCCCAGATTAATTCCCCTTTTGGGGGGGGGCGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGGGGGAAG
CGTCCCTGAAATAGTAAATATTATTGAGCTCTTTTTGCCCTTTTCCTGTCCGTTTTTTTAATTTCCTTTTTTGAGGTGGGAAAACTGAAA
CCCACCTTGATTCGTCCCCTCTCCCCCCTCCCCACCTTCCCTCGCCCTAATCCCCCAACGAGGAAGGAAGGAGCAGTTGGTTCAATCTCT
GGTAATCTATGCCAGCAATTATGACAATGTTAGCAGACCATGCAGCTCGTCAGCTGCTTGATTTCAGCCAAAAACTGGATATCAACTTAT
TAGATAATGTGGTGAATTGCTTATACCATGGAGAAGGAGCCCAGCAAAGAATGGCTCAAGAAGTACTGACACATTTAAAGGAGCATCCTG
ATGCTTGGACAAGAGTCGACACAATTTTGGAATTTTCTCAGAATATGAATACGAAATACTATGGACTACAAATTTTGGAAAATGTGATAA
AAACAAGGTGGAAGATTCTTCCAAGGAACCAGTGCGAAGATTGTATCTATGCTTTTCACATCAATAGCAAAGTTGACTCCTGAGGCAGCC
AATCCTTTCTTTAAGTTGTTGACTATGCTAATGGAGTTTGCTGGTGGACCTCCAGGAATGCCTCCCTTTGCATCTTATATTCTGCAGAGG
ATATGGGAGGTGATTGAATACAATCCTTCTCAGTGTCTAGATTGGTTGGCAGTGCAGACACCCCGAAATAAACTGGCACACAGCTGGGTC
TTACAGAATATGGAAAACTGGGTCGAGCGGTTTCTTTTGGCTCACAATTATCCTAGAGTGAGGACTTCTGCAGCTTATCTTCTGGTGTCC
CTTATACCAAGCAATTCATTCCGTCAGATGTTCCGGTCAACAAGGTCTTTGCACATCCCAACCCGTGACCTTCCACTCAGTCCAGACACA
ACAGTAGTCCTACATCAGGTCTACAACGTGCTCCTTGGTTTGCTCTCAAGAGCCAAACTTTATGTTGATGCTGCTGTTCATGGCACTACA
AAGCTAGTGCCCTATTTTAGCTTTATGACTTACTGTTTAATTTCCAAAACTGAGAAGCTGATGTTTTCCACATATTTCATGGATTTGTGG
AACCTTTTCCAGCCTAAACTTTCTGAGCCAGCAATAGCTACAAATCACAATAAACAGGCTTTGCTTTCATTTTGGTACAATGTCTGTGCT
GACTGTCCAGAGAATATCCGCCTTATTGTTCAGAACCCAGTGGTAACCAAGAACATTGCCTTCAATTACATCCTTGCTGACCATGATGAT
CAGGATGTGGTGCTTTTTAACCGTGGGATGCTGCCAGCGTACTATGGCATTCTGAGGCTCTGCTGTGAGCAGTCTCCTGCATTCACACGA
CAACTGGCTTCTCACCAGAACATCCAGTGGGCCTTTAAGAATCTTACACCACATGCCAGCCAATACCCTGGAGCAGTAGAAGAACTGTTT
AACCTGATGCAGCTGTTTATAGCTCAGAGGCCAGATATGAGAGAAGAAGAATTAGAAGATATTAAACAGTTCAAGAAAACAACCATAAGT
TGTTACTTACGTTGCTTAGATGGCCGCTCCTGCTGGACTACTTTAATAAGTGCCTTCAGAATACTATTAGAATCTGATGAAGACAGACTT
CTTGTTGTATTTAATCGAGGATTGATTCTAATGACAGAGTCTTTCAACACTTTGCACATGATGTATCACGAAGCTACAGCTTGCCATGTG
ACTGGAGATTTAGTAGAACTTCTGTCAATATTTCTTTCGGTTTTGAAGTCTACACGCCCTTATCTTCAGAGAAAAGATGTGAAACAAGCA
TTAATCCAGTGGCAGGAGCGAATTGAATTTGCCCATAAACTGTTAACTCTTCTTAATTCCTATAGTCCTCCAGAACTTAGAAATGCCTGT
ATAGATGTCCTCAAGGAACTTGTACTTTTGAGTCCCCATGATTTTCTTCATACTCTGGTTCCCTTTCTACAACACAACCATTGTACTTAC
CATCACAGTAATATACCAATGTCTCTTGGACCTTATTTCCCTTGTCGAGAAAATATCAAGCTAATAGGAGGGAAAAGCAATATTCGGCCT
CCGCGCCCTGAACTCAATATGTGCCTCTTGCCCACAATGGTGGAAACCAGTAAGGGCAAAGATGACGTTTATGATCGTATGCTGCTAGAC
TACTTCTTTTCTTATCATCAGTTCATCCATCTATTATGCCGAGTTGCAATCAACTGTGAAAAATTTACTGAAACATTAGTTAAGCTGAGT
GTCCTAGTTGCCTATGAAGGTTTGCCACTTCATCTTGCACTGTTCCCCAAACTTTGGACTGAGCTATGCCAGACTCAGTCTGCTATGTCA
AAAAACTGCATCAAGCTTTTGTGTGAAGATCCTGTTTTCGCAGAATATATTAAATGTATCCTAATGGATGAAAGAACTTTTTTAAACAAC
AACATTGTCTACACGTTCATGACACATTTCCTTCTAAAGGTTCAAAGTCAAGTGTTTTCTGAAGCAAACTGTGCCAATTTGATCAGCACT
CTTATTACAAACTTGATAAGCCAGTATCAGAACCTACAGTCTGATTTCTCCAACCGAGTTGAAATTTCCAAAGCAAGTGCTTCTTTAAAT
GGGGACCTGAGGGCACTCGCTTTGCTCCTGTCAGTACACACTCCCAAACAGTTAAACCCAGCTCTAATTCCAACTCTGCAAGAGCTTTTA
AGCAAATGCAGGACTTGTCTGCAACAGAGAAACTCACTCCAAGAGCAAGAAGCCAAAGAAAGAAAAACTAAAGATGATGAAGGAGCAACT
CCCATTAAAAGGCGGCGTGTTAGCAGTGATGAGGAGCACACTGTAGACAGCTGCATCAGTGACATGAAAACAGAAACCAGGGAGGTCCTG
ACCCCAACGAGCACTTCTGACAATGAGACCAGAGACTCCTCAATTATTGATCCAGGAACTGAGCAAGATCTTCCTTCCCCTGAAAATAGT
TCTGTTAAAGAATACCGAATGGAAGTTCCATCTTCGTTTTCAGAAGACATGTCAAATATCAGGTCACAGCATGCAGAAGAACAGTCCAAC
AATGGTAGATATGACGATTGTAAAGAATTTAAAGACCTCCACTGTTCCAAGGATTCTACCCTAGCTGAGGAAGAATCTGAGTTCCCTTCT
ACTTCTATCTCTGCAGTTCTGTCTGACTTAGCTGACTTGAGAAGCTGTGATGGCCAAGCTTTGCCCTCCCAGGACCCTGAGGTTGCTTTA
TCTCTCAGTTGTGGCCATTCCAGAGGACTCTTTAGTCATATGCAGCAACATGACATTTTAGATACCCTGTGTAGGACCATTGAATCTACA
ATCCATGTCGTCACAAGGATATCTGGCAAAGGAAACCAAGCTGCTTCTTGACATTAGGTGTAGCATGTCTACTTTTAAGTCCCTCACCCC
CAACCCCCATGCTGTTTGTATAAGTTTTGCTTATTTGTTTTTGTGCTTCAGTTTGTCCAGTGCTCTCTGCTTGAATGGCAAGATAGATTT
ATAGGCTTAATTCTTGGTCAGGCAGAACTCCAGATGAAAAAAACTTGCATCTTCAGTATACTTCCTAAAGGGCAATCAGATAATGGATAT
GTTTTATGTAATTAAGAGTTCACTTTAGTGGCTTTCATTTAATATGGCTGTCTGGGAAGAACAGGGTTGCCTAGCCCTGTACAATGTAAT
TTAAACTTACAGCATTTTTACTGTGTATGATATGGTGTCCTCTGTGCCAGTTTTGTACCTTATAGAGGCAGATTGCCTCCGATCGCTGTG
GTTCTTATTATCAAAATTAAGTTTACTTGTATACGGAACAACCACAAGAAATTTGATTCTGTAAAGAATCCTCTTTAGCTGTGGCCTGGC
AGTATATAAATGGTGCTTTATTTAACAGAATACCTGTGGAGGAAATAAAGCACACTTGATGTAAAAATAATTGTTTTATTTTTATTGACA

>99668_99668_2_XPO1-USP34_XPO1_chr2_61749746_ENST00000401558_USP34_chr2_61449798_ENST00000398571_length(amino acids)=960AA_BP=
MLFTSIAKLTPEAANPFFKLLTMLMEFAGGPPGMPPFASYILQRIWEVIEYNPSQCLDWLAVQTPRNKLAHSWVLQNMENWVERFLLAHN
YPRVRTSAAYLLVSLIPSNSFRQMFRSTRSLHIPTRDLPLSPDTTVVLHQVYNVLLGLLSRAKLYVDAAVHGTTKLVPYFSFMTYCLISK
TEKLMFSTYFMDLWNLFQPKLSEPAIATNHNKQALLSFWYNVCADCPENIRLIVQNPVVTKNIAFNYILADHDDQDVVLFNRGMLPAYYG
ILRLCCEQSPAFTRQLASHQNIQWAFKNLTPHASQYPGAVEELFNLMQLFIAQRPDMREEELEDIKQFKKTTISCYLRCLDGRSCWTTLI
SAFRILLESDEDRLLVVFNRGLILMTESFNTLHMMYHEATACHVTGDLVELLSIFLSVLKSTRPYLQRKDVKQALIQWQERIEFAHKLLT
LLNSYSPPELRNACIDVLKELVLLSPHDFLHTLVPFLQHNHCTYHHSNIPMSLGPYFPCRENIKLIGGKSNIRPPRPELNMCLLPTMVET
SKGKDDVYDRMLLDYFFSYHQFIHLLCRVAINCEKFTETLVKLSVLVAYEGLPLHLALFPKLWTELCQTQSAMSKNCIKLLCEDPVFAEY
IKCILMDERTFLNNNIVYTFMTHFLLKVQSQVFSEANCANLISTLITNLISQYQNLQSDFSNRVEISKASASLNGDLRALALLLSVHTPK
QLNPALIPTLQELLSKCRTCLQQRNSLQEQEAKERKTKDDEGATPIKRRRVSSDEEHTVDSCISDMKTETREVLTPTSTSDNETRDSSII
DPGTEQDLPSPENSSVKEYRMEVPSSFSEDMSNIRSQHAEEQSNNGRYDDCKEFKDLHCSKDSTLAEEESEFPSTSISAVLSDLADLRSC

--------------------------------------------------------------
>99668_99668_3_XPO1-USP34_XPO1_chr2_61749746_ENST00000404992_USP34_chr2_61448741_ENST00000398571_length(transcript)=4194nt_BP=708nt
AGCTTGGGATGGGGGAGGGAGGGGCTGCCGACTCCCTGTTCCTCCAGCAAGGAAACTCGAAAGCTCTCCGGTTTTGCAGAGTGGCATGTG
AAGTAGGAAAGATCAGTTTTTCAGGGGCCTGCACATGGGATTCCGTCTTGTAGTTCCTTTTCAGGGGTTTGAATGTGATAAGTTGGTTAA
ACCATTTACTGTTGGCCTTGTACAGTGGAGGATGCCCTGATTCTCCTTCATTCCGATGTCTGTGAGTTTGGGTTGGGTGGGAGGAAGTGG
TGTAGTAGAGGAAGCATTCAGTACTGGCTCAGCCCGGACCTCCTCTGATCACGCCGAGGCCATGCTGCATAGAGAAAGGGGCGGTGAACT
TAAGGCGCCTGGTCTAAATGCCTCCTCCGAGTAAGGGCGGGTAATCTATGCCAGCAATTATGACAATGTTAGCAGACCATGCAGCTCGTC
AGCTGCTTGATTTCAGCCAAAAACTGGATATCAACTTATTAGATAATGTGGTGAATTGCTTATACCATGGAGAAGGAGCCCAGCAAAGAA
TGGCTCAAGAAGTACTGACACATTTAAAGGAGCATCCTGATGCTTGGACAAGAGTCGACACAATTTTGGAATTTTCTCAGAATATGAATA
CGAAATACTATGGACTACAAATTTTGGAAAATGTGATAAAAACAAGGTGGAAGATTCTTCCAAGGAACCAGTGCGAAGGCAGCCAATCCT
TTCTTTAAGTTGTTGACTATGCTAATGGAGTTTGCTGGTGGACCTCCAGGAATGCCTCCCTTTGCATCTTATATTCTGCAGAGGATATGG
GAGGTGATTGAATACAATCCTTCTCAGTGTCTAGATTGGTTGGCAGTGCAGACACCCCGAAATAAACTGGCACACAGCTGGGTCTTACAG
AATATGGAAAACTGGGTCGAGCGGTTTCTTTTGGCTCACAATTATCCTAGAGTGAGGACTTCTGCAGCTTATCTTCTGGTGTCCCTTATA
CCAAGCAATTCATTCCGTCAGATGTTCCGGTCAACAAGGTCTTTGCACATCCCAACCCGTGACCTTCCACTCAGTCCAGACACAACAGTA
GTCCTACATCAGGTCTACAACGTGCTCCTTGGTTTGCTCTCAAGAGCCAAACTTTATGTTGATGCTGCTGTTCATGGCACTACAAAGCTA
GTGCCCTATTTTAGCTTTATGACTTACTGTTTAATTTCCAAAACTGAGAAGCTGATGTTTTCCACATATTTCATGGATTTGTGGAACCTT
TTCCAGCCTAAACTTTCTGAGCCAGCAATAGCTACAAATCACAATAAACAGGCTTTGCTTTCATTTTGGTACAATGTCTGTGCTGACTGT
CCAGAGAATATCCGCCTTATTGTTCAGAACCCAGTGGTAACCAAGAACATTGCCTTCAATTACATCCTTGCTGACCATGATGATCAGGAT
GTGGTGCTTTTTAACCGTGGGATGCTGCCAGCGTACTATGGCATTCTGAGGCTCTGCTGTGAGCAGTCTCCTGCATTCACACGACAACTG
GCTTCTCACCAGAACATCCAGTGGGCCTTTAAGAATCTTACACCACATGCCAGCCAATACCCTGGAGCAGTAGAAGAACTGTTTAACCTG
ATGCAGCTGTTTATAGCTCAGAGGCCAGATATGAGAGAAGAAGAATTAGAAGATATTAAACAGTTCAAGAAAACAACCATAAGTTGTTAC
TTACGTTGCTTAGATGGCCGCTCCTGCTGGACTACTTTAATAAGTGCCTTCAGAATACTATTAGAATCTGATGAAGACAGACTTCTTGTT
GTATTTAATCGAGGATTGATTCTAATGACAGAGTCTTTCAACACTTTGCACATGATGTATCACGAAGCTACAGCTTGCCATGTGACTGGA
GATTTAGTAGAACTTCTGTCAATATTTCTTTCGGTTTTGAAGTCTACACGCCCTTATCTTCAGAGAAAAGATGTGAAACAAGCATTAATC
CAGTGGCAGGAGCGAATTGAATTTGCCCATAAACTGTTAACTCTTCTTAATTCCTATAGTCCTCCAGAACTTAGAAATGCCTGTATAGAT
GTCCTCAAGGAACTTGTACTTTTGAGTCCCCATGATTTTCTTCATACTCTGGTTCCCTTTCTACAACACAACCATTGTACTTACCATCAC
AGTAATATACCAATGTCTCTTGGACCTTATTTCCCTTGTCGAGAAAATATCAAGCTAATAGGAGGGAAAAGCAATATTCGGCCTCCGCGC
CCTGAACTCAATATGTGCCTCTTGCCCACAATGGTGGAAACCAGTAAGGGCAAAGATGACGTTTATGATCGTATGCTGCTAGACTACTTC
TTTTCTTATCATCAGTTCATCCATCTATTATGCCGAGTTGCAATCAACTGTGAAAAATTTACTGAAACATTAGTTAAGCTGAGTGTCCTA
GTTGCCTATGAAGGTTTGCCACTTCATCTTGCACTGTTCCCCAAACTTTGGACTGAGCTATGCCAGACTCAGTCTGCTATGTCAAAAAAC
TGCATCAAGCTTTTGTGTGAAGATCCTGTTTTCGCAGAATATATTAAATGTATCCTAATGGATGAAAGAACTTTTTTAAACAACAACATT
GTCTACACGTTCATGACACATTTCCTTCTAAAGGTTCAAAGTCAAGTGTTTTCTGAAGCAAACTGTGCCAATTTGATCAGCACTCTTATT
ACAAACTTGATAAGCCAGTATCAGAACCTACAGTCTGATTTCTCCAACCGAGTTGAAATTTCCAAAGCAAGTGCTTCTTTAAATGGGGAC
CTGAGGGCACTCGCTTTGCTCCTGTCAGTACACACTCCCAAACAGTTAAACCCAGCTCTAATTCCAACTCTGCAAGAGCTTTTAAGCAAA
TGCAGGACTTGTCTGCAACAGAGAAACTCACTCCAAGAGCAAGAAGCCAAAGAAAGAAAAACTAAAGATGATGAAGGAGCAACTCCCATT
AAAAGGCGGCGTGTTAGCAGTGATGAGGAGCACACTGTAGACAGCTGCATCAGTGACATGAAAACAGAAACCAGGGAGGTCCTGACCCCA
ACGAGCACTTCTGACAATGAGACCAGAGACTCCTCAATTATTGATCCAGGAACTGAGCAAGATCTTCCTTCCCCTGAAAATAGTTCTGTT
AAAGAATACCGAATGGAAGTTCCATCTTCGTTTTCAGAAGACATGTCAAATATCAGGTCACAGCATGCAGAAGAACAGTCCAACAATGGT
AGATATGACGATTGTAAAGAATTTAAAGACCTCCACTGTTCCAAGGATTCTACCCTAGCTGAGGAAGAATCTGAGTTCCCTTCTACTTCT
ATCTCTGCAGTTCTGTCTGACTTAGCTGACTTGAGAAGCTGTGATGGCCAAGCTTTGCCCTCCCAGGACCCTGAGGTTGCTTTATCTCTC
AGTTGTGGCCATTCCAGAGGACTCTTTAGTCATATGCAGCAACATGACATTTTAGATACCCTGTGTAGGACCATTGAATCTACAATCCAT
GTCGTCACAAGGATATCTGGCAAAGGAAACCAAGCTGCTTCTTGACATTAGGTGTAGCATGTCTACTTTTAAGTCCCTCACCCCCAACCC
CCATGCTGTTTGTATAAGTTTTGCTTATTTGTTTTTGTGCTTCAGTTTGTCCAGTGCTCTCTGCTTGAATGGCAAGATAGATTTATAGGC
TTAATTCTTGGTCAGGCAGAACTCCAGATGAAAAAAACTTGCATCTTCAGTATACTTCCTAAAGGGCAATCAGATAATGGATATGTTTTA
TGTAATTAAGAGTTCACTTTAGTGGCTTTCATTTAATATGGCTGTCTGGGAAGAACAGGGTTGCCTAGCCCTGTACAATGTAATTTAAAC
TTACAGCATTTTTACTGTGTATGATATGGTGTCCTCTGTGCCAGTTTTGTACCTTATAGAGGCAGATTGCCTCCGATCGCTGTGGTTCTT
ATTATCAAAATTAAGTTTACTTGTATACGGAACAACCACAAGAAATTTGATTCTGTAAAGAATCCTCTTTAGCTGTGGCCTGGCAGTATA
TAAATGGTGCTTTATTTAACAGAATACCTGTGGAGGAAATAAAGCACACTTGATGTAAAAATAATTGTTTTATTTTTATTGACATGACTG

>99668_99668_3_XPO1-USP34_XPO1_chr2_61749746_ENST00000404992_USP34_chr2_61448741_ENST00000398571_length(amino acids)=941AA_BP=
MLTMLMEFAGGPPGMPPFASYILQRIWEVIEYNPSQCLDWLAVQTPRNKLAHSWVLQNMENWVERFLLAHNYPRVRTSAAYLLVSLIPSN
SFRQMFRSTRSLHIPTRDLPLSPDTTVVLHQVYNVLLGLLSRAKLYVDAAVHGTTKLVPYFSFMTYCLISKTEKLMFSTYFMDLWNLFQP
KLSEPAIATNHNKQALLSFWYNVCADCPENIRLIVQNPVVTKNIAFNYILADHDDQDVVLFNRGMLPAYYGILRLCCEQSPAFTRQLASH
QNIQWAFKNLTPHASQYPGAVEELFNLMQLFIAQRPDMREEELEDIKQFKKTTISCYLRCLDGRSCWTTLISAFRILLESDEDRLLVVFN
RGLILMTESFNTLHMMYHEATACHVTGDLVELLSIFLSVLKSTRPYLQRKDVKQALIQWQERIEFAHKLLTLLNSYSPPELRNACIDVLK
ELVLLSPHDFLHTLVPFLQHNHCTYHHSNIPMSLGPYFPCRENIKLIGGKSNIRPPRPELNMCLLPTMVETSKGKDDVYDRMLLDYFFSY
HQFIHLLCRVAINCEKFTETLVKLSVLVAYEGLPLHLALFPKLWTELCQTQSAMSKNCIKLLCEDPVFAEYIKCILMDERTFLNNNIVYT
FMTHFLLKVQSQVFSEANCANLISTLITNLISQYQNLQSDFSNRVEISKASASLNGDLRALALLLSVHTPKQLNPALIPTLQELLSKCRT
CLQQRNSLQEQEAKERKTKDDEGATPIKRRRVSSDEEHTVDSCISDMKTETREVLTPTSTSDNETRDSSIIDPGTEQDLPSPENSSVKEY
RMEVPSSFSEDMSNIRSQHAEEQSNNGRYDDCKEFKDLHCSKDSTLAEEESEFPSTSISAVLSDLADLRSCDGQALPSQDPEVALSLSCG

--------------------------------------------------------------
>99668_99668_4_XPO1-USP34_XPO1_chr2_61749746_ENST00000404992_USP34_chr2_61449798_ENST00000398571_length(transcript)=4239nt_BP=708nt
AGCTTGGGATGGGGGAGGGAGGGGCTGCCGACTCCCTGTTCCTCCAGCAAGGAAACTCGAAAGCTCTCCGGTTTTGCAGAGTGGCATGTG
AAGTAGGAAAGATCAGTTTTTCAGGGGCCTGCACATGGGATTCCGTCTTGTAGTTCCTTTTCAGGGGTTTGAATGTGATAAGTTGGTTAA
ACCATTTACTGTTGGCCTTGTACAGTGGAGGATGCCCTGATTCTCCTTCATTCCGATGTCTGTGAGTTTGGGTTGGGTGGGAGGAAGTGG
TGTAGTAGAGGAAGCATTCAGTACTGGCTCAGCCCGGACCTCCTCTGATCACGCCGAGGCCATGCTGCATAGAGAAAGGGGCGGTGAACT
TAAGGCGCCTGGTCTAAATGCCTCCTCCGAGTAAGGGCGGGTAATCTATGCCAGCAATTATGACAATGTTAGCAGACCATGCAGCTCGTC
AGCTGCTTGATTTCAGCCAAAAACTGGATATCAACTTATTAGATAATGTGGTGAATTGCTTATACCATGGAGAAGGAGCCCAGCAAAGAA
TGGCTCAAGAAGTACTGACACATTTAAAGGAGCATCCTGATGCTTGGACAAGAGTCGACACAATTTTGGAATTTTCTCAGAATATGAATA
CGAAATACTATGGACTACAAATTTTGGAAAATGTGATAAAAACAAGGTGGAAGATTCTTCCAAGGAACCAGTGCGAAGATTGTATCTATG
CTTTTCACATCAATAGCAAAGTTGACTCCTGAGGCAGCCAATCCTTTCTTTAAGTTGTTGACTATGCTAATGGAGTTTGCTGGTGGACCT
CCAGGAATGCCTCCCTTTGCATCTTATATTCTGCAGAGGATATGGGAGGTGATTGAATACAATCCTTCTCAGTGTCTAGATTGGTTGGCA
GTGCAGACACCCCGAAATAAACTGGCACACAGCTGGGTCTTACAGAATATGGAAAACTGGGTCGAGCGGTTTCTTTTGGCTCACAATTAT
CCTAGAGTGAGGACTTCTGCAGCTTATCTTCTGGTGTCCCTTATACCAAGCAATTCATTCCGTCAGATGTTCCGGTCAACAAGGTCTTTG
CACATCCCAACCCGTGACCTTCCACTCAGTCCAGACACAACAGTAGTCCTACATCAGGTCTACAACGTGCTCCTTGGTTTGCTCTCAAGA
GCCAAACTTTATGTTGATGCTGCTGTTCATGGCACTACAAAGCTAGTGCCCTATTTTAGCTTTATGACTTACTGTTTAATTTCCAAAACT
GAGAAGCTGATGTTTTCCACATATTTCATGGATTTGTGGAACCTTTTCCAGCCTAAACTTTCTGAGCCAGCAATAGCTACAAATCACAAT
AAACAGGCTTTGCTTTCATTTTGGTACAATGTCTGTGCTGACTGTCCAGAGAATATCCGCCTTATTGTTCAGAACCCAGTGGTAACCAAG
AACATTGCCTTCAATTACATCCTTGCTGACCATGATGATCAGGATGTGGTGCTTTTTAACCGTGGGATGCTGCCAGCGTACTATGGCATT
CTGAGGCTCTGCTGTGAGCAGTCTCCTGCATTCACACGACAACTGGCTTCTCACCAGAACATCCAGTGGGCCTTTAAGAATCTTACACCA
CATGCCAGCCAATACCCTGGAGCAGTAGAAGAACTGTTTAACCTGATGCAGCTGTTTATAGCTCAGAGGCCAGATATGAGAGAAGAAGAA
TTAGAAGATATTAAACAGTTCAAGAAAACAACCATAAGTTGTTACTTACGTTGCTTAGATGGCCGCTCCTGCTGGACTACTTTAATAAGT
GCCTTCAGAATACTATTAGAATCTGATGAAGACAGACTTCTTGTTGTATTTAATCGAGGATTGATTCTAATGACAGAGTCTTTCAACACT
TTGCACATGATGTATCACGAAGCTACAGCTTGCCATGTGACTGGAGATTTAGTAGAACTTCTGTCAATATTTCTTTCGGTTTTGAAGTCT
ACACGCCCTTATCTTCAGAGAAAAGATGTGAAACAAGCATTAATCCAGTGGCAGGAGCGAATTGAATTTGCCCATAAACTGTTAACTCTT
CTTAATTCCTATAGTCCTCCAGAACTTAGAAATGCCTGTATAGATGTCCTCAAGGAACTTGTACTTTTGAGTCCCCATGATTTTCTTCAT
ACTCTGGTTCCCTTTCTACAACACAACCATTGTACTTACCATCACAGTAATATACCAATGTCTCTTGGACCTTATTTCCCTTGTCGAGAA
AATATCAAGCTAATAGGAGGGAAAAGCAATATTCGGCCTCCGCGCCCTGAACTCAATATGTGCCTCTTGCCCACAATGGTGGAAACCAGT
AAGGGCAAAGATGACGTTTATGATCGTATGCTGCTAGACTACTTCTTTTCTTATCATCAGTTCATCCATCTATTATGCCGAGTTGCAATC
AACTGTGAAAAATTTACTGAAACATTAGTTAAGCTGAGTGTCCTAGTTGCCTATGAAGGTTTGCCACTTCATCTTGCACTGTTCCCCAAA
CTTTGGACTGAGCTATGCCAGACTCAGTCTGCTATGTCAAAAAACTGCATCAAGCTTTTGTGTGAAGATCCTGTTTTCGCAGAATATATT
AAATGTATCCTAATGGATGAAAGAACTTTTTTAAACAACAACATTGTCTACACGTTCATGACACATTTCCTTCTAAAGGTTCAAAGTCAA
GTGTTTTCTGAAGCAAACTGTGCCAATTTGATCAGCACTCTTATTACAAACTTGATAAGCCAGTATCAGAACCTACAGTCTGATTTCTCC
AACCGAGTTGAAATTTCCAAAGCAAGTGCTTCTTTAAATGGGGACCTGAGGGCACTCGCTTTGCTCCTGTCAGTACACACTCCCAAACAG
TTAAACCCAGCTCTAATTCCAACTCTGCAAGAGCTTTTAAGCAAATGCAGGACTTGTCTGCAACAGAGAAACTCACTCCAAGAGCAAGAA
GCCAAAGAAAGAAAAACTAAAGATGATGAAGGAGCAACTCCCATTAAAAGGCGGCGTGTTAGCAGTGATGAGGAGCACACTGTAGACAGC
TGCATCAGTGACATGAAAACAGAAACCAGGGAGGTCCTGACCCCAACGAGCACTTCTGACAATGAGACCAGAGACTCCTCAATTATTGAT
CCAGGAACTGAGCAAGATCTTCCTTCCCCTGAAAATAGTTCTGTTAAAGAATACCGAATGGAAGTTCCATCTTCGTTTTCAGAAGACATG
TCAAATATCAGGTCACAGCATGCAGAAGAACAGTCCAACAATGGTAGATATGACGATTGTAAAGAATTTAAAGACCTCCACTGTTCCAAG
GATTCTACCCTAGCTGAGGAAGAATCTGAGTTCCCTTCTACTTCTATCTCTGCAGTTCTGTCTGACTTAGCTGACTTGAGAAGCTGTGAT
GGCCAAGCTTTGCCCTCCCAGGACCCTGAGGTTGCTTTATCTCTCAGTTGTGGCCATTCCAGAGGACTCTTTAGTCATATGCAGCAACAT
GACATTTTAGATACCCTGTGTAGGACCATTGAATCTACAATCCATGTCGTCACAAGGATATCTGGCAAAGGAAACCAAGCTGCTTCTTGA
CATTAGGTGTAGCATGTCTACTTTTAAGTCCCTCACCCCCAACCCCCATGCTGTTTGTATAAGTTTTGCTTATTTGTTTTTGTGCTTCAG
TTTGTCCAGTGCTCTCTGCTTGAATGGCAAGATAGATTTATAGGCTTAATTCTTGGTCAGGCAGAACTCCAGATGAAAAAAACTTGCATC
TTCAGTATACTTCCTAAAGGGCAATCAGATAATGGATATGTTTTATGTAATTAAGAGTTCACTTTAGTGGCTTTCATTTAATATGGCTGT
CTGGGAAGAACAGGGTTGCCTAGCCCTGTACAATGTAATTTAAACTTACAGCATTTTTACTGTGTATGATATGGTGTCCTCTGTGCCAGT
TTTGTACCTTATAGAGGCAGATTGCCTCCGATCGCTGTGGTTCTTATTATCAAAATTAAGTTTACTTGTATACGGAACAACCACAAGAAA
TTTGATTCTGTAAAGAATCCTCTTTAGCTGTGGCCTGGCAGTATATAAATGGTGCTTTATTTAACAGAATACCTGTGGAGGAAATAAAGC
ACACTTGATGTAAAAATAATTGTTTTATTTTTATTGACATGACTGATTGATTGATTGCTATTCTGTGCACTTAATTAAACTGATTGTGAT

>99668_99668_4_XPO1-USP34_XPO1_chr2_61749746_ENST00000404992_USP34_chr2_61449798_ENST00000398571_length(amino acids)=960AA_BP=
MLFTSIAKLTPEAANPFFKLLTMLMEFAGGPPGMPPFASYILQRIWEVIEYNPSQCLDWLAVQTPRNKLAHSWVLQNMENWVERFLLAHN
YPRVRTSAAYLLVSLIPSNSFRQMFRSTRSLHIPTRDLPLSPDTTVVLHQVYNVLLGLLSRAKLYVDAAVHGTTKLVPYFSFMTYCLISK
TEKLMFSTYFMDLWNLFQPKLSEPAIATNHNKQALLSFWYNVCADCPENIRLIVQNPVVTKNIAFNYILADHDDQDVVLFNRGMLPAYYG
ILRLCCEQSPAFTRQLASHQNIQWAFKNLTPHASQYPGAVEELFNLMQLFIAQRPDMREEELEDIKQFKKTTISCYLRCLDGRSCWTTLI
SAFRILLESDEDRLLVVFNRGLILMTESFNTLHMMYHEATACHVTGDLVELLSIFLSVLKSTRPYLQRKDVKQALIQWQERIEFAHKLLT
LLNSYSPPELRNACIDVLKELVLLSPHDFLHTLVPFLQHNHCTYHHSNIPMSLGPYFPCRENIKLIGGKSNIRPPRPELNMCLLPTMVET
SKGKDDVYDRMLLDYFFSYHQFIHLLCRVAINCEKFTETLVKLSVLVAYEGLPLHLALFPKLWTELCQTQSAMSKNCIKLLCEDPVFAEY
IKCILMDERTFLNNNIVYTFMTHFLLKVQSQVFSEANCANLISTLITNLISQYQNLQSDFSNRVEISKASASLNGDLRALALLLSVHTPK
QLNPALIPTLQELLSKCRTCLQQRNSLQEQEAKERKTKDDEGATPIKRRRVSSDEEHTVDSCISDMKTETREVLTPTSTSDNETRDSSII
DPGTEQDLPSPENSSVKEYRMEVPSSFSEDMSNIRSQHAEEQSNNGRYDDCKEFKDLHCSKDSTLAEEESEFPSTSISAVLSDLADLRSC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for XPO1-USP34

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	XPO1	chr2:61749746	chr2:61448741	ENST00000401558	-	4	25	800_820	100.33333333333333	1072.0	HIV-1 Rev
Hgene	XPO1	chr2:61749746	chr2:61448741	ENST00000404992	-	4	25	800_820	100.33333333333333	1072.0	HIV-1 Rev
Hgene	XPO1	chr2:61749746	chr2:61448741	ENST00000406957	-	5	26	800_820	100.33333333333333	1072.0	HIV-1 Rev
Hgene	XPO1	chr2:61749746	chr2:61449798	ENST00000401558	-	4	25	800_820	100.33333333333333	1072.0	HIV-1 Rev
Hgene	XPO1	chr2:61749746	chr2:61449798	ENST00000404992	-	4	25	800_820	100.33333333333333	1072.0	HIV-1 Rev
Hgene	XPO1	chr2:61749746	chr2:61449798	ENST00000406957	-	5	26	800_820	100.33333333333333	1072.0	HIV-1 Rev
Hgene	XPO1	chr2:61749746	chr2:61448741	ENST00000401558	-	4	25	327_450	100.33333333333333	1072.0	Ran and nuclear export complex formation
Hgene	XPO1	chr2:61749746	chr2:61448741	ENST00000404992	-	4	25	327_450	100.33333333333333	1072.0	Ran and nuclear export complex formation
Hgene	XPO1	chr2:61749746	chr2:61448741	ENST00000406957	-	5	26	327_450	100.33333333333333	1072.0	Ran and nuclear export complex formation
Hgene	XPO1	chr2:61749746	chr2:61449798	ENST00000401558	-	4	25	327_450	100.33333333333333	1072.0	Ran and nuclear export complex formation
Hgene	XPO1	chr2:61749746	chr2:61449798	ENST00000404992	-	4	25	327_450	100.33333333333333	1072.0	Ran and nuclear export complex formation
Hgene	XPO1	chr2:61749746	chr2:61449798	ENST00000406957	-	5	26	327_450	100.33333333333333	1072.0	Ran and nuclear export complex formation
Hgene	XPO1	chr2:61749746	chr2:61448741	ENST00000401558	-	4	25	411_481	100.33333333333333	1072.0	RANBP3
Hgene	XPO1	chr2:61749746	chr2:61448741	ENST00000404992	-	4	25	411_481	100.33333333333333	1072.0	RANBP3
Hgene	XPO1	chr2:61749746	chr2:61448741	ENST00000406957	-	5	26	411_481	100.33333333333333	1072.0	RANBP3
Hgene	XPO1	chr2:61749746	chr2:61449798	ENST00000401558	-	4	25	411_481	100.33333333333333	1072.0	RANBP3
Hgene	XPO1	chr2:61749746	chr2:61449798	ENST00000404992	-	4	25	411_481	100.33333333333333	1072.0	RANBP3
Hgene	XPO1	chr2:61749746	chr2:61449798	ENST00000406957	-	5	26	411_481	100.33333333333333	1072.0	RANBP3

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for XPO1-USP34

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for XPO1-USP34

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source