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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:XPO7-RAN (FusionGDB2 ID:99708)

Fusion Gene Summary for XPO7-RAN

Fusion gene summary

Fusion gene information	Fusion gene name: XPO7-RAN
	Fusion gene ID: 99708
		Hgene	Tgene
	Gene symbol	XPO7	RAN
	Gene ID	23039	5901
	Gene name	exportin 7	RAN, member RAS oncogene family
	Synonyms	EXP7\|RANBP16	ARA24\|Gsp1\|TC4
	Cytomap	8p21.3	12q24.33
	Type of gene	protein-coding	protein-coding
	Description	exportin-7RAN binding protein 16	GTP-binding nuclear protein RanGTPase RanOK/SW-cl.81RanGTPaseandrogen receptor-associated protein 24guanosine triphosphatase Ranmember RAS oncogene familyras-like protein TC4ras-related nuclear protein
	Modification date	20200313	20200313
	UniProtAcc	.	RGPD8
	Ensembl transtripts involved in fusion gene	ENST00000252512, ENST00000433566, ENST00000434536, ENST00000518017,	ENST00000254675, ENST00000392367, ENST00000392369, ENST00000541630, ENST00000543796,
Fusion gene scores	* DoF score	15 X 7 X 7=735	3 X 3 X 2=18
	# samples	18	3
	** MAII score	log2(18/735*10)=-2.02974734339405 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: XPO7 [Title/Abstract] AND RAN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	XPO7(21856816)-RAN(131357380), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	XPO7	GO:0006611	protein export from nucleus	11024021
Tgene	RAN	GO:0006606	protein import into nucleus	9822603
Tgene	RAN	GO:0006611	protein export from nucleus	16449645\|31075303
Tgene	RAN	GO:0032092	positive regulation of protein binding	16449645
Tgene	RAN	GO:0046039	GTP metabolic process	26272610

Fusion gene breakpoints across XPO7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GJ	XPO7	chr8	21856816	+	RAN	chr12	131357380	+

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Fusion Gene ORF analysis for XPO7-RAN

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000252512	ENST00000254675	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
5CDS-5UTR	ENST00000252512	ENST00000392367	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
5CDS-5UTR	ENST00000252512	ENST00000392369	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
5CDS-5UTR	ENST00000252512	ENST00000541630	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
5CDS-5UTR	ENST00000433566	ENST00000254675	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
5CDS-5UTR	ENST00000433566	ENST00000392367	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
5CDS-5UTR	ENST00000433566	ENST00000392369	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
5CDS-5UTR	ENST00000433566	ENST00000541630	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
5CDS-5UTR	ENST00000434536	ENST00000254675	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
5CDS-5UTR	ENST00000434536	ENST00000392367	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
5CDS-5UTR	ENST00000434536	ENST00000392369	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
5CDS-5UTR	ENST00000434536	ENST00000541630	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
In-frame	ENST00000252512	ENST00000543796	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
In-frame	ENST00000433566	ENST00000543796	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
In-frame	ENST00000434536	ENST00000543796	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
intron-3CDS	ENST00000518017	ENST00000543796	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
intron-5UTR	ENST00000518017	ENST00000254675	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
intron-5UTR	ENST00000518017	ENST00000392367	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
intron-5UTR	ENST00000518017	ENST00000392369	XPO7	chr8	21856816	+	RAN	chr12	131357380	+
intron-5UTR	ENST00000518017	ENST00000541630	XPO7	chr8	21856816	+	RAN	chr12	131357380	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000434536

XPO7

chr8

21856816

ENST00000543796

RAN

chr12

131357380

5139

2772

102

3386

1094

ENST00000252512

XPO7

chr8

21856816

ENST00000543796

RAN

chr12

131357380

5110

2743

100

3357

1085

ENST00000433566

XPO7

chr8

21856816

ENST00000543796

RAN

chr12

131357380

5068

2701

3315

1086

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000434536	ENST00000543796	XPO7	chr8	21856816	+	RAN	chr12	131357380	+	0.000318592	0.9996815
ENST00000252512	ENST00000543796	XPO7	chr8	21856816	+	RAN	chr12	131357380	+	0.00033158	0.9996685
ENST00000433566	ENST00000543796	XPO7	chr8	21856816	+	RAN	chr12	131357380	+	0.000277904	0.99972206

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Fusion Genomic Features for XPO7-RAN

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
XPO7	chr8	21856816	+	RAN	chr12	131357380	+	0.99933416	0.000665841
XPO7	chr8	21856816	+	RAN	chr12	131357380	+	0.99933416	0.000665841

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for XPO7-RAN

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:21856816/chr12:131357380)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	RAN RGPD8
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	1765

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

XPO7

chr8:21856816

chr12:131357380

ENST00000252512

30_96

881

1088.0

Domain

Importin N-terminal

Tgene

RAN

chr8:21856816

chr12:131357380

ENST00000392369

122_125

217.0

Nucleotide binding

GTP

Tgene

RAN

chr8:21856816

chr12:131357380

ENST00000392369

150_152

217.0

Nucleotide binding

GTP

Tgene

RAN

chr8:21856816

chr12:131357380

ENST00000392369

18_25

217.0

Nucleotide binding

GTP

Tgene

RAN

chr8:21856816

chr12:131357380

ENST00000392369

36_42

217.0

Nucleotide binding

GTP

Tgene

RAN

chr8:21856816

chr12:131357380

ENST00000543796

122_125

217.0

Nucleotide binding

GTP

Tgene

RAN

chr8:21856816

chr12:131357380

ENST00000543796

150_152

217.0

Nucleotide binding

GTP

Tgene

RAN

chr8:21856816

chr12:131357380

ENST00000543796

18_25

217.0

Nucleotide binding

GTP

Tgene

RAN

chr8:21856816

chr12:131357380

ENST00000543796

36_42

217.0

Nucleotide binding

GTP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for XPO7-RAN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>99708_99708_1_XPO7-RAN_XPO7_chr8_21856816_ENST00000252512_RAN_chr12_131357380_ENST00000543796_length(transcript)=5110nt_BP=2743nt
GCGCAGCGGCGACGGCGTCGGCGGCGGCGGCGGCAGCGGCTCCGGCCGAGGTGCGCGCTGGGGGGGAGGGGGGGCCGGAGAGGAGCATGA
ATGGAGCAAAATGGCGGATCATGTGCAGAGCCTGGCCCAACTAGAGAATCTGTGCAAACAGCTGTATGAAACCACAGACACAACCACTCG
ACTCCAGGCAGAGAAAGCCTTGGTTGAATTTACCAACAGCCCTGATTGCCTGAGCAAGTGCCAGCTACTCCTCGAAAGAGGAAGTTCCTC
TTACTCCCAGTTACTGGCAGCTACATGCCTTACCAAGCTTGTATCACGCACAAACAACCCCCTACCATTGGAACAGCGAATAGATATTCG
GAACTATGTGCTCAACTACCTTGCCACTCGGCCGAAGTTGGCTACTTTCGTGACACAAGCACTTATTCAGTTATATGCCAGAATCACAAA
ACTGGGCTGGTTTGACTGTCAGAAGGATGACTATGTCTTCAGAAATGCAATCACAGACGTCACAAGGTTTTTACAGGATAGTGTTGAATA
CTGCATCATTGGTGTCACAATTTTATCTCAGCTAACCAATGAAATTAATCAAGCAGACACCACCCATCCTTTAACCAAGCACAGAAAAAT
AGCCTCTTCTTTTCGCGATTCATCATTATTTGATATCTTCACACTTTCCTGCAATTTACTAAAACAGGCTTCAGGAAAGAATCTAAACTT
GAATGATGAAAGTCAGCATGGCTTGCTCATGCAACTGCTCAAGCTCACTCATAACTGCCTCAACTTTGACTTCATCGGCACTTCCACTGA
TGAGTCCTCAGACGACCTGTGTACAGTGCAGATTCCCACCAGCTGGAGATCAGCCTTCTTAGATTCTTCAACCTTGCAGCTGTTTTTTGA
CCTGTATCATTCCATCCCTCCTTCATTTTCACCTCTGGTATTATCCTGCTTGGTACAGATCGCTTCAGTCAGAAGATCCCTGTTTAACAA
TGCAGAGAGGGCCAAGTTTCTCTCTCATCTTGTTGATGGTGTTAAACGAATACTGGAAAACCCACAGAGTTTATCAGACCCAAACAATTA
CCATGAGTTTTGCAGACTACTGGCCCGATTGAAGAGTAACTATCAACTGGGAGAATTGGTAAAGGTGGAAAACTACCCTGAGGTCATCCG
ATTGATAGCCAACTTCACAGTGACCAGCCTACAGCACTGGGAATTTGCTCCAAATAGTGTGCACTATCTTCTGAGCCTGTGGCAGCGGCT
GGCAGCCTCTGTGCCGTATGTCAAAGCCACAGAGCCCCACATGCTGGAAACTTACACTCCTGAGGTCACCAAAGCCTACATCACATCCCG
GTTGGAATCTGTGCACATCATACTGAGAGATGGCCTGGAAGATCCCCTGGAGGATACGGGGCTGGTCCAGCAGCAGTTGGACCAGCTGTC
CACCATTGGGCGTTGTGAATATGAGAAGACGTGTGCACTCCTCGTGCAGTTGTTTGACCAGTCGGCCCAGTCGTACCAGGAGCTGCTACA
GAGCGCCAGCGCAAGCCCAATGGACATTGCAGTGCAGGAGGGAAGGCTGACATGGCTGGTTTACATTATTGGAGCAGTGATCGGTGGCCG
GGTTTCTTTTGCCAGCACTGATGAGCAAGACGCCATGGATGGTGAGCTTGTCTGTCGGGTGCTCCAGCTGATGAACCTAACAGATTCTCG
TTTGGCCCAGGCGGGTAATGAGAAGCTAGAGTTGGCCATGCTGAGCTTTTTTGAACAGTTTCGTAAGATCTACATTGGGGACCAAGTGCA
GAAATCCTCTAAGCTGTACCGCCGACTCTCAGAAGTTCTGGGCTTGAATGATGAGACCATGGTCCTAAGCGTCTTCATAGGAAAAATCAT
CACCAACTTGAAGTACTGGGGCCGTTGTGAACCAATCACCTCCAAGACACTACAGCTTCTCAATGACCTGTCCATTGGGTACAGTAGCGT
AAGGAAGCTAGTGAAGCTTAGTGCGGTACAGTTCATGCTGAACAATCACACGAGCGAGCACTTTTCATTTTTGGGTATTAACAATCAGTC
CAACCTGACAGACATGCGGTGTCGGACTACCTTCTACACAGCACTTGGGCGTCTCCTCATGGTGGATTTAGGAGAGGATGAAGATCAGTA
TGAGCAGTTCATGCTGCCACTCACAGCAGCATTTGAGGCTGTGGCCCAGATGTTTAGCACCAATAGTTTCAACGAGCAGGAGGCAAAGCG
AACTCTAGTTGGCCTAGTAAGAGACCTGAGAGGGATCGCTTTCGCTTTCAATGCCAAGACCAGCTTCATGATGCTCTTTGAATGGATATA
TCCATCCTATATGCCAATTCTCCAACGGGCAATTGAGCTCTGGTACCATGATCCAGCCTGTACTACACCTGTACTCAAGTTGATGGCTGA
ATTGGTTCATAATAGGTCCCAGCGACTCCAGTTTGATGTCTCTTCCCCCAATGGCATCTTACTCTTCCGAGAAACCAGCAAGATGATAAC
AATGTATGGCAATCGCATCCTGACACTAGGAGAGGTCCCAAAGGATCAGGTCTATGCTCTGAAGCTCAAGGGCATCTCCATCTGCTTCTC
CATGCTGAAGGCTGCTCTCAGTGGGAGTTACGTCAATTTCGGAGTCTTTCGTCTCTATGGAGACGATGCCCTGGACAATGCTCTGCAGAC
CTTCATCAAGCTGCTCCTCTCTATTCCTCACAGTGATCTCTTGCTTGTATTGGTTGGTGATGGTGGTACTGGAAAAACGACCTTCGTGAA
ACGTCATTTGACTGGTGAATTTGAGAAGAAGTATGTAGCCACCTTGGGTGTTGAGGTTCATCCCCTAGTGTTCCACACCAACAGAGGACC
TATTAAGTTCAATGTATGGGACACAGCCGGCCAGGAGAAATTCGGTGGACTGAGAGATGGCTATTATATCCAAGCCCAGTGTGCCATCAT
AATGTTTGATGTAACATCGAGAGTTACTTACAAGAATGTGCCTAACTGGCATAGAGATCTGGTACGAGTGTGTGAAAACATCCCCATTGT
GTTGTGTGGCAACAAAGTGGATATTAAGGACAGGAAAGTGAAGGCGAAATCCATTGTCTTCCACCGAAAGAAGAATCTTCAGTACTACGA
CATTTCTGCCAAAAGTAACTACAACTTTGAAAAGCCCTTCCTCTGGCTTGCTAGGAAGCTCATTGGAGACCCTAACTTGGAATTTGTTGC
CATGCCTGCTCTCGCCCCACCAGAAGTTGTCATGGACCCAGCTTTGGCAGCACAGTATGAGCACGACTTAGAGGTTGCTCAGACAACTGC
TCTCCCGGATGAGGATGATGACCTGTGAGAATGAAGCTGGAGCCCAGCGTCAGAAGTCTAGTTTTATAGGCAGCTGTCCTGTGATGTCAG
CGGTGCAGCGTGTGTGCCACCTCATTATTATCTAGCTAAGCGGAACATGTGCTTCATCTGTGGGATGCTGAAGGAGATGAGTGGGCTTCG
GAGTGAATGTGGCAGTTTAAAAAATAACTTCATTGTTTGGACCTGCATATTTAGCTGTTTTGGAACGCAGTTGATTCCTTGAGTTTCATA
TATAAGACTGCTGCAGTCACATCACAATATTCAGTGGTGAAATCTTGTTTGTTACTGTCATTCCCATTCCTTTTCGTTTAGAATCAGAAT
AAAGTTGTATTTCAAATATCTAAGCAAGTGAACTCATCCCTTGTTTATAAATAGCATTTGGAAACCACTAAAGTAGGGAAGTTTTATGCC
ATGTTAATATTTGAATTGCCTTGCTTTTATCACTTAATTTGAAATCTATTGGGTTAATTTCTCCCTATGTTTATTTTTGTACATTTGAGC
CATGTCACACAAACTGATGATGACAGGTCAGCAGTATTCTATTTGGTTAGAAGGGTTACATGGTGTAAATATTAGTGCAGTTAAGCTAAA
GCAGTGTTTGCTCCACCTTCATATTGGCTAGGTAGGGTCACCTAGGGAAGCACTTGCTCAAAATCTGTGACCTGTCAGAATAAAAATGTG
GTTTGTACATATCAAATAGATATTTTAAGGGTAATATTTTCTTTTATGGCAAAAGTAATCATGTTTTAATGTAGAACCTCAAACAGGATG
GAACATCAGTGGATGGCAGGAGGTTGGGAATTCTTGCTGTTAAAAATAATTACAAATTTTGCACTTTTTTGTTTGAATGTTAGATGCTTA
GTGTGAAGTTGATACGCAAGGAAAATGGTCCATGTTTACCCACAGTTTTCAGGTACTCCTAGACTTTAAAGATGTCTTGAACATTTAAGT
TCTTCAGCAGTTCACACTACACCGTTTTTTTGTTTTTTTTTCCCCCCCGGGAGGGTTTTTTTGTAGGGCAGCACAGCAGAGCAGGACATG
GATGAAATACTAGGAATATGCACAGTGGGGCAGTGTGGGGGCTTCTCAGTAATGGAGAACAGTTGGTGAAACTTTTTTTTTTTTTTAACT
AAGCATTTAATTTATCTTGCATATTTTCCACATTTAAAAATGAATTAGGTCTATTAGGATAATTAGGAGTTTGATCCCATCAACACTATT
CTTGTAGCAGTTAGGAATCTTGAGCTATTTTTTTCTCATACGATTACTATAGTCCAGTTTACCAAAGTTTTCTTTAGATGTCTGATAATC
TTGAGATGATTGCTTACCTTAAAAGGTATAGAAAGGATCACTTAAATATATGGAAAAATGAAATAAGGGTGAAGCTGAATAAAGTTCTAC
TTACTGTATTAACTGGCAACAGTTGAGTTTCTTAAGATCTGAATTGCTGTGTATGTTACGCTGTATTCAGAACCAGTTTCTAACCAGCCT
GTGAGATGGGAAGTTTTTTCCCCATAATTGGGATGAAACCTTTCATTCAGGTATTTTGAATTGAAGGTGTATGTGTTGTTTGTAACCTTG
TGGAGATTGCAAGTGGTGTTGACATTCTGGATCTTCTATGTAACAGTTGAAATTTGGAAGTGACGTCACTTACCTGTCTAACGTGGTGTG

>99708_99708_1_XPO7-RAN_XPO7_chr8_21856816_ENST00000252512_RAN_chr12_131357380_ENST00000543796_length(amino acids)=1085AA_BP=881
MADHVQSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYV
LNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASS
FRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYH
SIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRLIA
NFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLSTIG
RCEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQ
AGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKIITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKL
VKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLV
GLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITMYG
NRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLLVLVGDGGTGKTTFVKRHL
TGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCG
NKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPD

--------------------------------------------------------------
>99708_99708_2_XPO7-RAN_XPO7_chr8_21856816_ENST00000433566_RAN_chr12_131357380_ENST00000543796_length(transcript)=5068nt_BP=2701nt
GGAACCAAAGTAAGAGTTTAAAGTGCAACAGAAGAGAGTCTGCTGAACTTTAGACATGAGGGATCCAGGGAGGAAGAGCCTGGCCCAACT
AGAGAATCTGTGCAAACAGCTGTATGAAACCACAGACACAACCACTCGACTCCAGGCAGAGAAAGCCTTGGTTGAATTTACCAACAGCCC
TGATTGCCTGAGCAAGTGCCAGCTACTCCTCGAAAGAGGAAGTTCCTCTTACTCCCAGTTACTGGCAGCTACATGCCTTACCAAGCTTGT
ATCACGCACAAACAACCCCCTACCATTGGAACAGCGAATAGATATTCGGAACTATGTGCTCAACTACCTTGCCACTCGGCCGAAGTTGGC
TACTTTCGTGACACAAGCACTTATTCAGTTATATGCCAGAATCACAAAACTGGGCTGGTTTGACTGTCAGAAGGATGACTATGTCTTCAG
AAATGCAATCACAGACGTCACAAGGTTTTTACAGGATAGTGTTGAATACTGCATCATTGGTGTCACAATTTTATCTCAGCTAACCAATGA
AATTAATCAAGCAGACACCACCCATCCTTTAACCAAGCACAGAAAAATAGCCTCTTCTTTTCGCGATTCATCATTATTTGATATCTTCAC
ACTTTCCTGCAATTTACTAAAACAGGCTTCAGGAAAGAATCTAAACTTGAATGATGAAAGTCAGCATGGCTTGCTCATGCAACTGCTCAA
GCTCACTCATAACTGCCTCAACTTTGACTTCATCGGCACTTCCACTGATGAGTCCTCAGACGACCTGTGTACAGTGCAGATTCCCACCAG
CTGGAGATCAGCCTTCTTAGATTCTTCAACCTTGCAGCTGTTTTTTGACCTGTATCATTCCATCCCTCCTTCATTTTCACCTCTGGTATT
ATCCTGCTTGGTACAGATCGCTTCAGTCAGAAGATCCCTGTTTAACAATGCAGAGAGGGCCAAGTTTCTCTCTCATCTTGTTGATGGTGT
TAAACGAATACTGGAAAACCCACAGAGTTTATCAGACCCAAACAATTACCATGAGTTTTGCAGACTACTGGCCCGATTGAAGAGTAACTA
TCAACTGGGAGAATTGGTAAAGGTGGAAAACTACCCTGAGGTCATCCGATTGATAGCCAACTTCACAGTGACCAGCCTACAGCACTGGGA
ATTTGCTCCAAATAGTGTGCACTATCTTCTGAGCCTGTGGCAGCGGCTGGCAGCCTCTGTGCCGTATGTCAAAGCCACAGAGCCCCACAT
GCTGGAAACTTACACTCCTGAGGTCACCAAAGCCTACATCACATCCCGGTTGGAATCTGTGCACATCATACTGAGAGATGGCCTGGAAGA
TCCCCTGGAGGATACGGGGCTGGTCCAGCAGCAGTTGGACCAGCTGTCCACCATTGGGCGTTGTGAATATGAGAAGACGTGTGCACTCCT
CGTGCAGTTGTTTGACCAGTCGGCCCAGTCGTACCAGGAGCTGCTACAGAGCGCCAGCGCAAGCCCAATGGACATTGCAGTGCAGGAGGG
AAGGCTGACATGGCTGGTTTACATTATTGGAGCAGTGATCGGTGGCCGGGTTTCTTTTGCCAGCACTGATGAGCAAGACGCCATGGATGG
TGAGCTTGTCTGTCGGGTGCTCCAGCTGATGAACCTAACAGATTCTCGTTTGGCCCAGGCGGGTAATGAGAAGCTAGAGTTGGCCATGCT
GAGCTTTTTTGAACAGTTTCGTAAGATCTACATTGGGGACCAAGTGCAGAAATCCTCTAAGCTGTACCGCCGACTCTCAGAAGTTCTGGG
CTTGAATGATGAGACCATGGTCCTAAGCGTCTTCATAGGAAAAATCATCACCAACTTGAAGTACTGGGGCCGTTGTGAACCAATCACCTC
CAAGACACTACAGCTTCTCAATGACCTGTCCATTGGGTACAGTAGCGTAAGGAAGCTAGTGAAGCTTAGTGCGGTACAGTTCATGCTGAA
CAATCACACGAGCGAGCACTTTTCATTTTTGGGTATTAACAATCAGTCCAACCTGACAGACATGCGGTGTCGGACTACCTTCTACACAGC
ACTTGGGCGTCTCCTCATGGTGGATTTAGGAGAGGATGAAGATCAGTATGAGCAGTTCATGCTGCCACTCACAGCAGCATTTGAGGCTGT
GGCCCAGATGTTTAGCACCAATAGTTTCAACGAGCAGGAGGCAAAGCGAACTCTAGTTGGCCTAGTAAGAGACCTGAGAGGGATCGCTTT
CGCTTTCAATGCCAAGACCAGCTTCATGATGCTCTTTGAATGGATATATCCATCCTATATGCCAATTCTCCAACGGGCAATTGAGCTCTG
GTACCATGATCCAGCCTGTACTACACCTGTACTCAAGTTGATGGCTGAATTGGTTCATAATAGGTCCCAGCGACTCCAGTTTGATGTCTC
TTCCCCCAATGGCATCTTACTCTTCCGAGAAACCAGCAAGATGATAACAATGTATGGCAATCGCATCCTGACACTAGGAGAGGTCCCAAA
GGATCAGGTCTATGCTCTGAAGCTCAAGGGCATCTCCATCTGCTTCTCCATGCTGAAGGCTGCTCTCAGTGGGAGTTACGTCAATTTCGG
AGTCTTTCGTCTCTATGGAGACGATGCCCTGGACAATGCTCTGCAGACCTTCATCAAGCTGCTCCTCTCTATTCCTCACAGTGATCTCTT
GCTTGTATTGGTTGGTGATGGTGGTACTGGAAAAACGACCTTCGTGAAACGTCATTTGACTGGTGAATTTGAGAAGAAGTATGTAGCCAC
CTTGGGTGTTGAGGTTCATCCCCTAGTGTTCCACACCAACAGAGGACCTATTAAGTTCAATGTATGGGACACAGCCGGCCAGGAGAAATT
CGGTGGACTGAGAGATGGCTATTATATCCAAGCCCAGTGTGCCATCATAATGTTTGATGTAACATCGAGAGTTACTTACAAGAATGTGCC
TAACTGGCATAGAGATCTGGTACGAGTGTGTGAAAACATCCCCATTGTGTTGTGTGGCAACAAAGTGGATATTAAGGACAGGAAAGTGAA
GGCGAAATCCATTGTCTTCCACCGAAAGAAGAATCTTCAGTACTACGACATTTCTGCCAAAAGTAACTACAACTTTGAAAAGCCCTTCCT
CTGGCTTGCTAGGAAGCTCATTGGAGACCCTAACTTGGAATTTGTTGCCATGCCTGCTCTCGCCCCACCAGAAGTTGTCATGGACCCAGC
TTTGGCAGCACAGTATGAGCACGACTTAGAGGTTGCTCAGACAACTGCTCTCCCGGATGAGGATGATGACCTGTGAGAATGAAGCTGGAG
CCCAGCGTCAGAAGTCTAGTTTTATAGGCAGCTGTCCTGTGATGTCAGCGGTGCAGCGTGTGTGCCACCTCATTATTATCTAGCTAAGCG
GAACATGTGCTTCATCTGTGGGATGCTGAAGGAGATGAGTGGGCTTCGGAGTGAATGTGGCAGTTTAAAAAATAACTTCATTGTTTGGAC
CTGCATATTTAGCTGTTTTGGAACGCAGTTGATTCCTTGAGTTTCATATATAAGACTGCTGCAGTCACATCACAATATTCAGTGGTGAAA
TCTTGTTTGTTACTGTCATTCCCATTCCTTTTCGTTTAGAATCAGAATAAAGTTGTATTTCAAATATCTAAGCAAGTGAACTCATCCCTT
GTTTATAAATAGCATTTGGAAACCACTAAAGTAGGGAAGTTTTATGCCATGTTAATATTTGAATTGCCTTGCTTTTATCACTTAATTTGA
AATCTATTGGGTTAATTTCTCCCTATGTTTATTTTTGTACATTTGAGCCATGTCACACAAACTGATGATGACAGGTCAGCAGTATTCTAT
TTGGTTAGAAGGGTTACATGGTGTAAATATTAGTGCAGTTAAGCTAAAGCAGTGTTTGCTCCACCTTCATATTGGCTAGGTAGGGTCACC
TAGGGAAGCACTTGCTCAAAATCTGTGACCTGTCAGAATAAAAATGTGGTTTGTACATATCAAATAGATATTTTAAGGGTAATATTTTCT
TTTATGGCAAAAGTAATCATGTTTTAATGTAGAACCTCAAACAGGATGGAACATCAGTGGATGGCAGGAGGTTGGGAATTCTTGCTGTTA
AAAATAATTACAAATTTTGCACTTTTTTGTTTGAATGTTAGATGCTTAGTGTGAAGTTGATACGCAAGGAAAATGGTCCATGTTTACCCA
CAGTTTTCAGGTACTCCTAGACTTTAAAGATGTCTTGAACATTTAAGTTCTTCAGCAGTTCACACTACACCGTTTTTTTGTTTTTTTTTC
CCCCCCGGGAGGGTTTTTTTGTAGGGCAGCACAGCAGAGCAGGACATGGATGAAATACTAGGAATATGCACAGTGGGGCAGTGTGGGGGC
TTCTCAGTAATGGAGAACAGTTGGTGAAACTTTTTTTTTTTTTTAACTAAGCATTTAATTTATCTTGCATATTTTCCACATTTAAAAATG
AATTAGGTCTATTAGGATAATTAGGAGTTTGATCCCATCAACACTATTCTTGTAGCAGTTAGGAATCTTGAGCTATTTTTTTCTCATACG
ATTACTATAGTCCAGTTTACCAAAGTTTTCTTTAGATGTCTGATAATCTTGAGATGATTGCTTACCTTAAAAGGTATAGAAAGGATCACT
TAAATATATGGAAAAATGAAATAAGGGTGAAGCTGAATAAAGTTCTACTTACTGTATTAACTGGCAACAGTTGAGTTTCTTAAGATCTGA
ATTGCTGTGTATGTTACGCTGTATTCAGAACCAGTTTCTAACCAGCCTGTGAGATGGGAAGTTTTTTCCCCATAATTGGGATGAAACCTT
TCATTCAGGTATTTTGAATTGAAGGTGTATGTGTTGTTTGTAACCTTGTGGAGATTGCAAGTGGTGTTGACATTCTGGATCTTCTATGTA
ACAGTTGAAATTTGGAAGTGACGTCACTTACCTGTCTAACGTGGTGTGGGAGAGAATTTACAAGTCCTTTATTGAAAGAATAATTGTTGC

>99708_99708_2_XPO7-RAN_XPO7_chr8_21856816_ENST00000433566_RAN_chr12_131357380_ENST00000543796_length(amino acids)=1086AA_BP=882
MRDPGRKSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNY
VLNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIAS
SFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLY
HSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRLI
ANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLSTI
GRCEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLA
QAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKIITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRK
LVKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTL
VGLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITMY
GNRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLLVLVGDGGTGKTTFVKRH
LTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLC
GNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALP

--------------------------------------------------------------
>99708_99708_3_XPO7-RAN_XPO7_chr8_21856816_ENST00000434536_RAN_chr12_131357380_ENST00000543796_length(transcript)=5139nt_BP=2772nt
AGGCGCAGCGGCGACGGCGTCGGCGGCGGCGGCGGCAGCGGCTCCGGCCGAGGTGCGCGCTGGGGGGGAGGGGGGGCCGGAGAGGAGCAT
GAATGGAGCAAAATGGCGGATCATGTGCAGAGCCTGGCCCAACTAGAGAATCTGTGCAAACAGCTGTATGAAACCACAGACACAACCACT
CGACTCCAGGCAGAGAAAGCCTTGGTTGAATTTACCAACAGCCCTGATTGCCTGAGCAAGTGCCAGCTACTCCTCGAAAGAGGAAGTTCC
TCTTACTCCCAGTTACTGGCAGCTACATGCCTTACCAAGCTTGTATCACGCACAAACAACCCCCTACCATTGGAACAGCGAATAGATATT
CGGAACTATGTGCTCAACTACCTTGCCACTCGGCCGAAGTTGGCTACTTTCGTGACACAAGCACTTATTCAGTTATATGCCAGAATCACA
AAACTGGGCTGGTTTGACTGTCAGAAGGATGACTATGTCTTCAGAAATGCAATCACAGACGTCACAAGGTTTTTACAGGATAGTGTTGAA
TACTGCATCATTGGTGTCACAATTTTATCTCAGCTAACCAATGAAATTAATCAAGTAAGTGCTACAGCCTTCCTCATTGAAGCAGACACC
ACCCATCCTTTAACCAAGCACAGAAAAATAGCCTCTTCTTTTCGCGATTCATCATTATTTGATATCTTCACACTTTCCTGCAATTTACTA
AAACAGGCTTCAGGAAAGAATCTAAACTTGAATGATGAAAGTCAGCATGGCTTGCTCATGCAACTGCTCAAGCTCACTCATAACTGCCTC
AACTTTGACTTCATCGGCACTTCCACTGATGAGTCCTCAGACGACCTGTGTACAGTGCAGATTCCCACCAGCTGGAGATCAGCCTTCTTA
GATTCTTCAACCTTGCAGCTGTTTTTTGACCTGTATCATTCCATCCCTCCTTCATTTTCACCTCTGGTATTATCCTGCTTGGTACAGATC
GCTTCAGTCAGAAGATCCCTGTTTAACAATGCAGAGAGGGCCAAGTTTCTCTCTCATCTTGTTGATGGTGTTAAACGAATACTGGAAAAC
CCACAGAGTTTATCAGACCCAAACAATTACCATGAGTTTTGCAGACTACTGGCCCGATTGAAGAGTAACTATCAACTGGGAGAATTGGTA
AAGGTGGAAAACTACCCTGAGGTCATCCGATTGATAGCCAACTTCACAGTGACCAGCCTACAGCACTGGGAATTTGCTCCAAATAGTGTG
CACTATCTTCTGAGCCTGTGGCAGCGGCTGGCAGCCTCTGTGCCGTATGTCAAAGCCACAGAGCCCCACATGCTGGAAACTTACACTCCT
GAGGTCACCAAAGCCTACATCACATCCCGGTTGGAATCTGTGCACATCATACTGAGAGATGGCCTGGAAGATCCCCTGGAGGATACGGGG
CTGGTCCAGCAGCAGTTGGACCAGCTGTCCACCATTGGGCGTTGTGAATATGAGAAGACGTGTGCACTCCTCGTGCAGTTGTTTGACCAG
TCGGCCCAGTCGTACCAGGAGCTGCTACAGAGCGCCAGCGCAAGCCCAATGGACATTGCAGTGCAGGAGGGAAGGCTGACATGGCTGGTT
TACATTATTGGAGCAGTGATCGGTGGCCGGGTTTCTTTTGCCAGCACTGATGAGCAAGACGCCATGGATGGTGAGCTTGTCTGTCGGGTG
CTCCAGCTGATGAACCTAACAGATTCTCGTTTGGCCCAGGCGGGTAATGAGAAGCTAGAGTTGGCCATGCTGAGCTTTTTTGAACAGTTT
CGTAAGATCTACATTGGGGACCAAGTGCAGAAATCCTCTAAGCTGTACCGCCGACTCTCAGAAGTTCTGGGCTTGAATGATGAGACCATG
GTCCTAAGCGTCTTCATAGGAAAAATCATCACCAACTTGAAGTACTGGGGCCGTTGTGAACCAATCACCTCCAAGACACTACAGCTTCTC
AATGACCTGTCCATTGGGTACAGTAGCGTAAGGAAGCTAGTGAAGCTTAGTGCGGTACAGTTCATGCTGAACAATCACACGAGCGAGCAC
TTTTCATTTTTGGGTATTAACAATCAGTCCAACCTGACAGACATGCGGTGTCGGACTACCTTCTACACAGCACTTGGGCGTCTCCTCATG
GTGGATTTAGGAGAGGATGAAGATCAGTATGAGCAGTTCATGCTGCCACTCACAGCAGCATTTGAGGCTGTGGCCCAGATGTTTAGCACC
AATAGTTTCAACGAGCAGGAGGCAAAGCGAACTCTAGTTGGCCTAGTAAGAGACCTGAGAGGGATCGCTTTCGCTTTCAATGCCAAGACC
AGCTTCATGATGCTCTTTGAATGGATATATCCATCCTATATGCCAATTCTCCAACGGGCAATTGAGCTCTGGTACCATGATCCAGCCTGT
ACTACACCTGTACTCAAGTTGATGGCTGAATTGGTTCATAATAGGTCCCAGCGACTCCAGTTTGATGTCTCTTCCCCCAATGGCATCTTA
CTCTTCCGAGAAACCAGCAAGATGATAACAATGTATGGCAATCGCATCCTGACACTAGGAGAGGTCCCAAAGGATCAGGTCTATGCTCTG
AAGCTCAAGGGCATCTCCATCTGCTTCTCCATGCTGAAGGCTGCTCTCAGTGGGAGTTACGTCAATTTCGGAGTCTTTCGTCTCTATGGA
GACGATGCCCTGGACAATGCTCTGCAGACCTTCATCAAGCTGCTCCTCTCTATTCCTCACAGTGATCTCTTGCTTGTATTGGTTGGTGAT
GGTGGTACTGGAAAAACGACCTTCGTGAAACGTCATTTGACTGGTGAATTTGAGAAGAAGTATGTAGCCACCTTGGGTGTTGAGGTTCAT
CCCCTAGTGTTCCACACCAACAGAGGACCTATTAAGTTCAATGTATGGGACACAGCCGGCCAGGAGAAATTCGGTGGACTGAGAGATGGC
TATTATATCCAAGCCCAGTGTGCCATCATAATGTTTGATGTAACATCGAGAGTTACTTACAAGAATGTGCCTAACTGGCATAGAGATCTG
GTACGAGTGTGTGAAAACATCCCCATTGTGTTGTGTGGCAACAAAGTGGATATTAAGGACAGGAAAGTGAAGGCGAAATCCATTGTCTTC
CACCGAAAGAAGAATCTTCAGTACTACGACATTTCTGCCAAAAGTAACTACAACTTTGAAAAGCCCTTCCTCTGGCTTGCTAGGAAGCTC
ATTGGAGACCCTAACTTGGAATTTGTTGCCATGCCTGCTCTCGCCCCACCAGAAGTTGTCATGGACCCAGCTTTGGCAGCACAGTATGAG
CACGACTTAGAGGTTGCTCAGACAACTGCTCTCCCGGATGAGGATGATGACCTGTGAGAATGAAGCTGGAGCCCAGCGTCAGAAGTCTAG
TTTTATAGGCAGCTGTCCTGTGATGTCAGCGGTGCAGCGTGTGTGCCACCTCATTATTATCTAGCTAAGCGGAACATGTGCTTCATCTGT
GGGATGCTGAAGGAGATGAGTGGGCTTCGGAGTGAATGTGGCAGTTTAAAAAATAACTTCATTGTTTGGACCTGCATATTTAGCTGTTTT
GGAACGCAGTTGATTCCTTGAGTTTCATATATAAGACTGCTGCAGTCACATCACAATATTCAGTGGTGAAATCTTGTTTGTTACTGTCAT
TCCCATTCCTTTTCGTTTAGAATCAGAATAAAGTTGTATTTCAAATATCTAAGCAAGTGAACTCATCCCTTGTTTATAAATAGCATTTGG
AAACCACTAAAGTAGGGAAGTTTTATGCCATGTTAATATTTGAATTGCCTTGCTTTTATCACTTAATTTGAAATCTATTGGGTTAATTTC
TCCCTATGTTTATTTTTGTACATTTGAGCCATGTCACACAAACTGATGATGACAGGTCAGCAGTATTCTATTTGGTTAGAAGGGTTACAT
GGTGTAAATATTAGTGCAGTTAAGCTAAAGCAGTGTTTGCTCCACCTTCATATTGGCTAGGTAGGGTCACCTAGGGAAGCACTTGCTCAA
AATCTGTGACCTGTCAGAATAAAAATGTGGTTTGTACATATCAAATAGATATTTTAAGGGTAATATTTTCTTTTATGGCAAAAGTAATCA
TGTTTTAATGTAGAACCTCAAACAGGATGGAACATCAGTGGATGGCAGGAGGTTGGGAATTCTTGCTGTTAAAAATAATTACAAATTTTG
CACTTTTTTGTTTGAATGTTAGATGCTTAGTGTGAAGTTGATACGCAAGGAAAATGGTCCATGTTTACCCACAGTTTTCAGGTACTCCTA
GACTTTAAAGATGTCTTGAACATTTAAGTTCTTCAGCAGTTCACACTACACCGTTTTTTTGTTTTTTTTTCCCCCCCGGGAGGGTTTTTT
TGTAGGGCAGCACAGCAGAGCAGGACATGGATGAAATACTAGGAATATGCACAGTGGGGCAGTGTGGGGGCTTCTCAGTAATGGAGAACA
GTTGGTGAAACTTTTTTTTTTTTTTAACTAAGCATTTAATTTATCTTGCATATTTTCCACATTTAAAAATGAATTAGGTCTATTAGGATA
ATTAGGAGTTTGATCCCATCAACACTATTCTTGTAGCAGTTAGGAATCTTGAGCTATTTTTTTCTCATACGATTACTATAGTCCAGTTTA
CCAAAGTTTTCTTTAGATGTCTGATAATCTTGAGATGATTGCTTACCTTAAAAGGTATAGAAAGGATCACTTAAATATATGGAAAAATGA
AATAAGGGTGAAGCTGAATAAAGTTCTACTTACTGTATTAACTGGCAACAGTTGAGTTTCTTAAGATCTGAATTGCTGTGTATGTTACGC
TGTATTCAGAACCAGTTTCTAACCAGCCTGTGAGATGGGAAGTTTTTTCCCCATAATTGGGATGAAACCTTTCATTCAGGTATTTTGAAT
TGAAGGTGTATGTGTTGTTTGTAACCTTGTGGAGATTGCAAGTGGTGTTGACATTCTGGATCTTCTATGTAACAGTTGAAATTTGGAAGT
GACGTCACTTACCTGTCTAACGTGGTGTGGGAGAGAATTTACAAGTCCTTTATTGAAAGAATAATTGTTGCAAAATATATTGCTTCTACT

>99708_99708_3_XPO7-RAN_XPO7_chr8_21856816_ENST00000434536_RAN_chr12_131357380_ENST00000543796_length(amino acids)=1094AA_BP=890
MADHVQSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYV
LNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQVSATAFLIEADTTHPL
TKHRKIASSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSST
LQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVEN
YPEVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQ
QLDQLSTIGRCEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLM
NLTDSRLAQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKIITNLKYWGRCEPITSKTLQLLNDLS
IGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFN
EQEAKRTLVGLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRE
TSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLLVLVGDGGTG
KTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVC
ENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for XPO7-RAN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for XPO7-RAN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for XPO7-RAN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source