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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:XRCC5-ABCB4 (FusionGDB2 ID:99760)

Fusion Gene Summary for XRCC5-ABCB4

check button Fusion gene summary
Fusion gene informationFusion gene name: XRCC5-ABCB4
Fusion gene ID: 99760
HgeneTgene
Gene symbol

XRCC5

ABCB4

Gene ID

7520

5244

Gene nameX-ray repair cross complementing 5ATP binding cassette subfamily B member 4
SynonymsKARP-1|KARP1|KU80|KUB2|Ku86|NFIVABC21|GBD1|ICP3|MDR2|MDR2/3|MDR3|PFIC-3|PGY3
Cytomap

2q35

7q21.12

Type of geneprotein-codingprotein-coding
DescriptionX-ray repair cross-complementing protein 586 kDa subunit of Ku antigenATP-dependent DNA helicase 2 subunit 2ATP-dependent DNA helicase II 80 kDa subunitCTC box-binding factor 85 kDa subunitCTC85CTCBFDNA repair protein XRCC5Ku autoantigen, 80kDaKuphosphatidylcholine translocator ABCB4ATP-binding cassette sub-family B member 4ATP-binding cassette, sub-family B (MDR/TAP), member 4P-glycoprotein 3P-glycoprotein-3/multiple drug resistance-3multidrug resistance protein 3multiple drug resistance 3
Modification date2020031320200315
UniProtAcc.

P21439

Ensembl transtripts involved in fusion geneENST00000471649, ENST00000392132, 
ENST00000392133, 		ENST00000265723, 
ENST00000358400, ENST00000359206, 
ENST00000453593, ENST00000545634, 
Fusion gene scores* DoF score13 X 10 X 7=9104 X 5 X 4=80
# samples 124
** MAII scorelog2(12/910*10)=-2.92283213947754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XRCC5 [Title/Abstract] AND ABCB4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointXRCC5(216997110)-ABCB4(87031618), # samples:1
Anticipated loss of major functional domain due to fusion event.XRCC5-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
XRCC5-ABCB4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
XRCC5-ABCB4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXRCC5

GO:0002218

activation of innate immune response

28712728

HgeneXRCC5

GO:0006303

double-strand break repair via nonhomologous end joining

26359349

HgeneXRCC5

GO:0045860

positive regulation of protein kinase activity

22504299

HgeneXRCC5

GO:0071480

cellular response to gamma radiation

26359349

TgeneABCB4

GO:0032376

positive regulation of cholesterol transport

17523162

TgeneABCB4

GO:0045332

phospholipid translocation

8898203

TgeneABCB4

GO:0055088

lipid homeostasis

17523162

TgeneABCB4

GO:0061092

positive regulation of phospholipid translocation

17523162

TgeneABCB4

GO:0099040

ceramide translocation

8898203

TgeneABCB4

GO:1903413

cellular response to bile acid

17523162

TgeneABCB4

GO:2001140

positive regulation of phospholipid transport

8898203


check buttonFusion gene breakpoints across XRCC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCB4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BC-A10T-01AXRCC5chr2

216997110

+ABCB4chr7

87031618

-


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Fusion Gene ORF analysis for XRCC5-ABCB4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000471649ENST00000265723XRCC5chr2

216997110

+ABCB4chr7

87031618

-
3UTR-3CDSENST00000471649ENST00000358400XRCC5chr2

216997110

+ABCB4chr7

87031618

-
3UTR-3CDSENST00000471649ENST00000359206XRCC5chr2

216997110

+ABCB4chr7

87031618

-
3UTR-3CDSENST00000471649ENST00000453593XRCC5chr2

216997110

+ABCB4chr7

87031618

-
3UTR-3CDSENST00000471649ENST00000545634XRCC5chr2

216997110

+ABCB4chr7

87031618

-
Frame-shiftENST00000392132ENST00000359206XRCC5chr2

216997110

+ABCB4chr7

87031618

-
Frame-shiftENST00000392132ENST00000453593XRCC5chr2

216997110

+ABCB4chr7

87031618

-
Frame-shiftENST00000392132ENST00000545634XRCC5chr2

216997110

+ABCB4chr7

87031618

-
Frame-shiftENST00000392133ENST00000359206XRCC5chr2

216997110

+ABCB4chr7

87031618

-
Frame-shiftENST00000392133ENST00000453593XRCC5chr2

216997110

+ABCB4chr7

87031618

-
Frame-shiftENST00000392133ENST00000545634XRCC5chr2

216997110

+ABCB4chr7

87031618

-
In-frameENST00000392132ENST00000265723XRCC5chr2

216997110

+ABCB4chr7

87031618

-
In-frameENST00000392132ENST00000358400XRCC5chr2

216997110

+ABCB4chr7

87031618

-
In-frameENST00000392133ENST00000265723XRCC5chr2

216997110

+ABCB4chr7

87031618

-
In-frameENST00000392133ENST00000358400XRCC5chr2

216997110

+ABCB4chr7

87031618

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392133XRCC5chr2216997110+ENST00000358400ABCB4chr787031618-18321574711780569
ENST00000392133XRCC5chr2216997110+ENST00000265723ABCB4chr787031618-18281574711780569
ENST00000392132XRCC5chr2216997110+ENST00000358400ABCB4chr787031618-15111253561459467
ENST00000392132XRCC5chr2216997110+ENST00000265723ABCB4chr787031618-15071253561459467

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392133ENST00000358400XRCC5chr2216997110+ABCB4chr787031618-0.0022787490.99772125
ENST00000392133ENST00000265723XRCC5chr2216997110+ABCB4chr787031618-0.0023429120.99765706
ENST00000392132ENST00000358400XRCC5chr2216997110+ABCB4chr787031618-0.0005512360.9994487
ENST00000392132ENST00000265723XRCC5chr2216997110+ABCB4chr787031618-0.000567960.999432

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Fusion Genomic Features for XRCC5-ABCB4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for XRCC5-ABCB4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:216997110/chr7:87031618)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCB4

P21439

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571, PubMed:28012258). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity). {ECO:0000250|UniProtKB:P21440, ECO:0000269|PubMed:17523162, ECO:0000269|PubMed:21820390, ECO:0000269|PubMed:23468132, ECO:0000269|PubMed:24045840, ECO:0000269|PubMed:24594635, ECO:0000269|PubMed:24723470, ECO:0000269|PubMed:24806754, ECO:0000269|PubMed:28012258, ECO:0000269|PubMed:7957936, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9366571}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392132+1021138_165371733.0RegionNote=Leucine-zipper
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392133+1223138_165371733.0RegionNote=Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392132+1021478_519371733.0Compositional biasNote=Pro-rich
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392133+1223478_519371733.0Compositional biasNote=Pro-rich
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392132+1021251_460371733.0DomainNote=Ku
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392133+1223251_460371733.0DomainNote=Ku
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392132+1021720_728371733.0MotifNote=EEXXXDL motif
HgeneXRCC5chr2:216997110chr7:87031618ENST00000392133+1223720_728371733.0MotifNote=EEXXXDL motif
TgeneABCB4chr2:216997110chr7:87031618ENST0000026572326281034_127912181287.0DomainABC transporter 2
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628394_63012181287.0DomainABC transporter 1
TgeneABCB4chr2:216997110chr7:87031618ENST00000265723262857_35912181287.0DomainABC transmembrane type-1 1
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628711_99912181287.0DomainABC transmembrane type-1 2
TgeneABCB4chr2:216997110chr7:87031618ENST0000035840025271034_127911641233.0DomainABC transporter 2
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527394_63011641233.0DomainABC transporter 1
TgeneABCB4chr2:216997110chr7:87031618ENST00000358400252757_35911641233.0DomainABC transmembrane type-1 1
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527711_99911641233.0DomainABC transmembrane type-1 2
TgeneABCB4chr2:216997110chr7:87031618ENST0000035920626281034_127912111280.0DomainABC transporter 2
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628394_63012111280.0DomainABC transporter 1
TgeneABCB4chr2:216997110chr7:87031618ENST00000359206262857_35912111280.0DomainABC transmembrane type-1 1
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628711_99912111280.0DomainABC transmembrane type-1 2
TgeneABCB4chr2:216997110chr7:87031618ENST0000045359324261034_127911641233.0DomainABC transporter 2
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426394_63011641233.0DomainABC transporter 1
TgeneABCB4chr2:216997110chr7:87031618ENST00000453593242657_35911641233.0DomainABC transmembrane type-1 1
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426711_99911641233.0DomainABC transmembrane type-1 2
TgeneABCB4chr2:216997110chr7:87031618ENST0000054563425271034_127912111280.0DomainABC transporter 2
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527394_63012111280.0DomainABC transporter 1
TgeneABCB4chr2:216997110chr7:87031618ENST00000545634252757_35912111280.0DomainABC transmembrane type-1 1
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527711_99912111280.0DomainABC transmembrane type-1 2
TgeneABCB4chr2:216997110chr7:87031618ENST0000026572326281069_107612181287.0Nucleotide bindingATP 2
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628429_43612181287.0Nucleotide bindingATP 1
TgeneABCB4chr2:216997110chr7:87031618ENST0000035840025271069_107611641233.0Nucleotide bindingATP 2
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527429_43611641233.0Nucleotide bindingATP 1
TgeneABCB4chr2:216997110chr7:87031618ENST0000035920626281069_107612111280.0Nucleotide bindingATP 2
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628429_43612111280.0Nucleotide bindingATP 1
TgeneABCB4chr2:216997110chr7:87031618ENST0000045359324261069_107611641233.0Nucleotide bindingATP 2
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426429_43611641233.0Nucleotide bindingATP 1
TgeneABCB4chr2:216997110chr7:87031618ENST0000054563425271069_107612111280.0Nucleotide bindingATP 2
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527429_43612111280.0Nucleotide bindingATP 1
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628140_18812181287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST0000026572326281_5012181287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628211_21712181287.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628239_29612181287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628319_33212181287.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628355_71112181287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628733_75512181287.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST00000265723262874_11812181287.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628777_83112181287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628853_85312181287.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628874_93312181287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628957_97212181287.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628995_128612181287.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527140_18811641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST0000035840025271_5011641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527211_21711641233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527239_29611641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527319_33211641233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527355_71111641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527733_75511641233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST00000358400252774_11811641233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527777_83111641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527853_85311641233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527874_93311641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527957_97211641233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527995_128611641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628140_18812111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST0000035920626281_5012111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628211_21712111280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628239_29612111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628319_33212111280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628355_71112111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628733_75512111280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST00000359206262874_11812111280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628777_83112111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628853_85312111280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628874_93312111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628957_97212111280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628995_128612111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426140_18811641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST0000045359324261_5011641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426211_21711641233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426239_29611641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426319_33211641233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426355_71111641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426733_75511641233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST00000453593242674_11811641233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426777_83111641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426853_85311641233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426874_93311641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426957_97211641233.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426995_128611641233.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527140_18812111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST0000054563425271_5012111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527211_21712111280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527239_29612111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527319_33212111280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527355_71112111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527733_75512111280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST00000545634252774_11812111280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527777_83112111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527853_85312111280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527874_93312111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527957_97212111280.0Topological domainExtracellular
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527995_128612111280.0Topological domainCytoplasmic
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628119_13912181287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628189_21012181287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628218_23812181287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628297_31812181287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628333_35412181287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST00000265723262851_7312181287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628712_73212181287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628756_77612181287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628832_85212181287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628854_87312181287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628934_95612181287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628973_99412181287.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527119_13911641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527189_21011641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527218_23811641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527297_31811641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527333_35411641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST00000358400252751_7311641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527712_73211641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527756_77611641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527832_85211641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527854_87311641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527934_95611641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527973_99411641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628119_13912111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628189_21012111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628218_23812111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628297_31812111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628333_35412111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST00000359206262851_7312111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628712_73212111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628756_77612111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628832_85212111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628854_87312111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628934_95612111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628973_99412111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426119_13911641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426189_21011641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426218_23811641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426297_31811641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426333_35411641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST00000453593242651_7311641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426712_73211641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426756_77611641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426832_85211641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426854_87311641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426934_95611641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426973_99411641233.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527119_13912111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527189_21012111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527218_23812111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527297_31812111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527333_35412111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST00000545634252751_7312111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527712_73212111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527756_77612111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527832_85212111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527854_87312111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527934_95612111280.0TransmembraneHelical
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527973_99412111280.0TransmembraneHelical


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Fusion Gene Sequence for XRCC5-ABCB4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99760_99760_1_XRCC5-ABCB4_XRCC5_chr2_216997110_ENST00000392132_ABCB4_chr7_87031618_ENST00000265723_length(transcript)=1507nt_BP=1253nt
ACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAAGCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACAC
GGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGAGGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTA
TGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTATAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGC
GACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAGTCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGT
ATCAGAACATCACAGTGCACAGACATCTGATGCTACCAGATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAAC
AGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATGTGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAA
TATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGCTGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCT
TCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGGACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCAC
TAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGATAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAA
TTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCTTCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTG
GCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGATTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCC
TAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCTTAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGT
TCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGGATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGG
GATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCATGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGTTGTCC
AAGAAGCCCTGGACAAAGCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCAGACTTAATAGTGG
TGTTTCAGAATGGGAGAGTCAAGGAGCATGGCACGCATCAGCAGCTGCTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGG

>99760_99760_1_XRCC5-ABCB4_XRCC5_chr2_216997110_ENST00000392132_ABCB4_chr7_87031618_ENST00000265723_length(amino acids)=467AA_BP=399
MPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTD
GTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIH
SLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIER
HSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMK
YKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ

--------------------------------------------------------------
>99760_99760_2_XRCC5-ABCB4_XRCC5_chr2_216997110_ENST00000392132_ABCB4_chr7_87031618_ENST00000358400_length(transcript)=1511nt_BP=1253nt
ACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAAGCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACAC
GGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGAGGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTA
TGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTATAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGC
GACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAGTCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGT
ATCAGAACATCACAGTGCACAGACATCTGATGCTACCAGATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAAC
AGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATGTGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAA
TATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGCTGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCT
TCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGGACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCAC
TAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGATAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAA
TTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCTTCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTG
GCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGATTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCC
TAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCTTAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGT
TCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGGATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGG
GATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCATGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGTTGTCC
AAGAAGCCCTGGACAAAGCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCAGACTTAATAGTGG
TGTTTCAGAATGGGAGAGTCAAGGAGCATGGCACGCATCAGCAGCTGCTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGG

>99760_99760_2_XRCC5-ABCB4_XRCC5_chr2_216997110_ENST00000392132_ABCB4_chr7_87031618_ENST00000358400_length(amino acids)=467AA_BP=399
MPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTD
GTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIH
SLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIER
HSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMK
YKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ

--------------------------------------------------------------
>99760_99760_3_XRCC5-ABCB4_XRCC5_chr2_216997110_ENST00000392133_ABCB4_chr7_87031618_ENST00000265723_length(transcript)=1828nt_BP=1574nt
AGAAACCCCACAAAAATTAGCTGGGCTTGGTGGCACACACCTGTGGTCCCAGCTACCTGGGAGGCTGAGCTCTGGATCGTACAAGAAGGG
AGACAAGGACCACTGACAAGATATGCGTTTCAGGCGGCTCAAACACCACACGCTCCCGACTACGGCGGAATGGAGAGAATGTGCGCATGC
TCGGCGGGAATCTGCGCATGCTCGGCGGGAATCTGCGCATGCTCGGAGAGAATCTGCGCATGCTCGGCCGGAATCTGCGCGAGCTCGGCG
GGAATCTGCGCAAGCTCGGCGGGAATCTGCGCATGCTCAGAGTTCCGGGGCACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAA
GCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACACGGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGA
GGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTATGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTA
TAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGCGACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAG
TCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGTATCAGAACATCACAGTGCACAGACATCTGATGCTACCAG
ATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAACAGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATG
TGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAATATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGC
TGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCTTCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGG
ACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCACTAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGA
TAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAATTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCT
TCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTGGCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGA
TTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCCTAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCT
TAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGTTCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGG
ATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGGGATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCA
TGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGTTGTCCAAGAAGCCCTGGACAAAGCCAGAGAAGGCCGCACCTGCA
TTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCAGACTTAATAGTGGTGTTTCAGAATGGGAGAGTCAAGGAGCATGGCACGCATC
AGCAGCTGCTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGGACACAGAACTTATGAACTTTTGCTACAGTATATT

>99760_99760_3_XRCC5-ABCB4_XRCC5_chr2_216997110_ENST00000392133_ABCB4_chr7_87031618_ENST00000265723_length(amino acids)=569AA_BP=501
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAEN
KDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSS
RFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSES
LRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDI
VPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRV

--------------------------------------------------------------
>99760_99760_4_XRCC5-ABCB4_XRCC5_chr2_216997110_ENST00000392133_ABCB4_chr7_87031618_ENST00000358400_length(transcript)=1832nt_BP=1574nt
AGAAACCCCACAAAAATTAGCTGGGCTTGGTGGCACACACCTGTGGTCCCAGCTACCTGGGAGGCTGAGCTCTGGATCGTACAAGAAGGG
AGACAAGGACCACTGACAAGATATGCGTTTCAGGCGGCTCAAACACCACACGCTCCCGACTACGGCGGAATGGAGAGAATGTGCGCATGC
TCGGCGGGAATCTGCGCATGCTCGGCGGGAATCTGCGCATGCTCGGAGAGAATCTGCGCATGCTCGGCCGGAATCTGCGCGAGCTCGGCG
GGAATCTGCGCAAGCTCGGCGGGAATCTGCGCATGCTCAGAGTTCCGGGGCACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAA
GCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACACGGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGA
GGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTATGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTA
TAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGCGACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAG
TCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGTATCAGAACATCACAGTGCACAGACATCTGATGCTACCAG
ATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAACAGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATG
TGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAATATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGC
TGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCTTCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGG
ACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCACTAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGA
TAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAATTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCT
TCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTGGCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGA
TTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCCTAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCT
TAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGTTCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGG
ATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGGGATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCA
TGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGTTGTCCAAGAAGCCCTGGACAAAGCCAGAGAAGGCCGCACCTGCA
TTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCAGACTTAATAGTGGTGTTTCAGAATGGGAGAGTCAAGGAGCATGGCACGCATC
AGCAGCTGCTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGGACACAGAACTTATGAACTTTTGCTACAGTATATT

>99760_99760_4_XRCC5-ABCB4_XRCC5_chr2_216997110_ENST00000392133_ABCB4_chr7_87031618_ENST00000358400_length(amino acids)=569AA_BP=501
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAEN
KDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSS
RFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSES
LRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDI
VPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for XRCC5-ABCB4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneABCB4chr2:216997110chr7:87031618ENST000002657232628625_6471218.01287.0HAX1
TgeneABCB4chr2:216997110chr7:87031618ENST000003584002527625_6471164.01233.0HAX1
TgeneABCB4chr2:216997110chr7:87031618ENST000003592062628625_6471211.01280.0HAX1
TgeneABCB4chr2:216997110chr7:87031618ENST000004535932426625_6471164.01233.0HAX1
TgeneABCB4chr2:216997110chr7:87031618ENST000005456342527625_6471211.01280.0HAX1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for XRCC5-ABCB4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for XRCC5-ABCB4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource