FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:XRCC5-RMDN1 (FusionGDB2 ID:99769)

Fusion Gene Summary for XRCC5-RMDN1

check button Fusion gene summary
Fusion gene informationFusion gene name: XRCC5-RMDN1
Fusion gene ID: 99769
HgeneTgene
Gene symbol

XRCC5

RMDN1

Gene ID

7520

51115

Gene nameX-ray repair cross complementing 5regulator of microtubule dynamics 1
SynonymsKARP-1|KARP1|KU80|KUB2|Ku86|NFIVCGI-90|FAM82B|RMD-1|RMD1
Cytomap

2q35

8q21.3

Type of geneprotein-codingprotein-coding
DescriptionX-ray repair cross-complementing protein 586 kDa subunit of Ku antigenATP-dependent DNA helicase 2 subunit 2ATP-dependent DNA helicase II 80 kDa subunitCTC box-binding factor 85 kDa subunitCTC85CTCBFDNA repair protein XRCC5Ku autoantigen, 80kDaKuregulator of microtubule dynamics protein 1family with sequence similarity 82, member Bmicrotubule-associated protein
Modification date2020031320200313
UniProtAcc.

Q96DB5

Ensembl transtripts involved in fusion geneENST00000471649, ENST00000392132, 
ENST00000392133, 		ENST00000406452, 
ENST00000430676, ENST00000519966, 
ENST00000523911, ENST00000518772, 
Fusion gene scores* DoF score13 X 10 X 7=9106 X 6 X 2=72
# samples 126
** MAII scorelog2(12/910*10)=-2.92283213947754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XRCC5 [Title/Abstract] AND RMDN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointXRCC5(216997110)-RMDN1(87489553), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXRCC5

GO:0002218

activation of innate immune response

28712728

HgeneXRCC5

GO:0006303

double-strand break repair via nonhomologous end joining

26359349

HgeneXRCC5

GO:0045860

positive regulation of protein kinase activity

22504299

HgeneXRCC5

GO:0071480

cellular response to gamma radiation

26359349


check buttonFusion gene breakpoints across XRCC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RMDN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4QI-01AXRCC5chr2

216997110

+RMDN1chr8

87489553

-


Top

Fusion Gene ORF analysis for XRCC5-RMDN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000471649ENST00000406452XRCC5chr2

216997110

+RMDN1chr8

87489553

-
3UTR-3CDSENST00000471649ENST00000430676XRCC5chr2

216997110

+RMDN1chr8

87489553

-
3UTR-3CDSENST00000471649ENST00000519966XRCC5chr2

216997110

+RMDN1chr8

87489553

-
3UTR-3CDSENST00000471649ENST00000523911XRCC5chr2

216997110

+RMDN1chr8

87489553

-
3UTR-intronENST00000471649ENST00000518772XRCC5chr2

216997110

+RMDN1chr8

87489553

-
5CDS-intronENST00000392132ENST00000518772XRCC5chr2

216997110

+RMDN1chr8

87489553

-
5CDS-intronENST00000392133ENST00000518772XRCC5chr2

216997110

+RMDN1chr8

87489553

-
In-frameENST00000392132ENST00000406452XRCC5chr2

216997110

+RMDN1chr8

87489553

-
In-frameENST00000392132ENST00000430676XRCC5chr2

216997110

+RMDN1chr8

87489553

-
In-frameENST00000392132ENST00000519966XRCC5chr2

216997110

+RMDN1chr8

87489553

-
In-frameENST00000392132ENST00000523911XRCC5chr2

216997110

+RMDN1chr8

87489553

-
In-frameENST00000392133ENST00000406452XRCC5chr2

216997110

+RMDN1chr8

87489553

-
In-frameENST00000392133ENST00000430676XRCC5chr2

216997110

+RMDN1chr8

87489553

-
In-frameENST00000392133ENST00000519966XRCC5chr2

216997110

+RMDN1chr8

87489553

-
In-frameENST00000392133ENST00000523911XRCC5chr2

216997110

+RMDN1chr8

87489553

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392133XRCC5chr2216997110+ENST00000406452RMDN1chr887489553-37481574711789572
ENST00000392133XRCC5chr2216997110+ENST00000523911RMDN1chr887489553-18271574711723550
ENST00000392133XRCC5chr2216997110+ENST00000519966RMDN1chr887489553-20381574711750559
ENST00000392133XRCC5chr2216997110+ENST00000430676RMDN1chr887489553-19861574711789572
ENST00000392132XRCC5chr2216997110+ENST00000406452RMDN1chr887489553-34271253561468470
ENST00000392132XRCC5chr2216997110+ENST00000523911RMDN1chr887489553-15061253561402448
ENST00000392132XRCC5chr2216997110+ENST00000519966RMDN1chr887489553-17171253561429457
ENST00000392132XRCC5chr2216997110+ENST00000430676RMDN1chr887489553-16651253561468470

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392133ENST00000406452XRCC5chr2216997110+RMDN1chr887489553-0.0003218860.99967813
ENST00000392133ENST00000523911XRCC5chr2216997110+RMDN1chr887489553-0.0012033380.9987967
ENST00000392133ENST00000519966XRCC5chr2216997110+RMDN1chr887489553-0.0008489130.9991511
ENST00000392133ENST00000430676XRCC5chr2216997110+RMDN1chr887489553-0.000754850.99924517
ENST00000392132ENST00000406452XRCC5chr2216997110+RMDN1chr887489553-0.0001599630.99984
ENST00000392132ENST00000523911XRCC5chr2216997110+RMDN1chr887489553-0.0003686980.9996313
ENST00000392132ENST00000519966XRCC5chr2216997110+RMDN1chr887489553-0.0003099270.99969006
ENST00000392132ENST00000430676XRCC5chr2216997110+RMDN1chr887489553-0.0002504020.9997496

Top

Fusion Genomic Features for XRCC5-RMDN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for XRCC5-RMDN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:216997110/chr8:87489553)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RMDN1

Q96DB5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXRCC5chr2:216997110chr8:87489553ENST00000392132+1021138_165371733.0RegionNote=Leucine-zipper
HgeneXRCC5chr2:216997110chr8:87489553ENST00000392133+1223138_165371733.0RegionNote=Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXRCC5chr2:216997110chr8:87489553ENST00000392132+1021478_519371733.0Compositional biasNote=Pro-rich
HgeneXRCC5chr2:216997110chr8:87489553ENST00000392133+1223478_519371733.0Compositional biasNote=Pro-rich
HgeneXRCC5chr2:216997110chr8:87489553ENST00000392132+1021251_460371733.0DomainNote=Ku
HgeneXRCC5chr2:216997110chr8:87489553ENST00000392133+1223251_460371733.0DomainNote=Ku
HgeneXRCC5chr2:216997110chr8:87489553ENST00000392132+1021720_728371733.0MotifNote=EEXXXDL motif
HgeneXRCC5chr2:216997110chr8:87489553ENST00000392133+1223720_728371733.0MotifNote=EEXXXDL motif
TgeneRMDN1chr2:216997110chr8:87489553ENST00000406452610168_204243315.0RepeatNote=TPR 1
TgeneRMDN1chr2:216997110chr8:87489553ENST00000406452610222_258243315.0RepeatNote=TPR 2


Top

Fusion Gene Sequence for XRCC5-RMDN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99769_99769_1_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392132_RMDN1_chr8_87489553_ENST00000406452_length(transcript)=3427nt_BP=1253nt
ACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAAGCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACAC
GGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGAGGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTA
TGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTATAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGC
GACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAGTCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGT
ATCAGAACATCACAGTGCACAGACATCTGATGCTACCAGATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAAC
AGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATGTGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAA
TATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGCTGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCT
TCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGGACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCAC
TAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGATAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAA
TTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCTTCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTG
GCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGATTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCC
TAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCTTAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGT
TCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGGATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGG
GATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCATGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCCTTAG
GCTACTTTCACAGGGCAGAACAAGTGGATCCAAACTTCTACAGCAAAAACTTACTTCTTTTAGGAAAGACATACTTGAAACTACACAACA
AAAAGCTTGCTGCTTTCTGGCTAATGAAAGCCAAGGACTATCCAGCACACACAGAGGAGGATAAACAGATACAGACAGAAGCTGCTCAGT
TGCTTACAAGTTTCAGTGAGAAGAATTGAGAACTTTTCAGAGAAGATTTATGAAATAGCTAATAAACATTGCCTTTTCTTTTAATTCTAA
ACTTAATATATGAACTATAACTGTTCTACGGCTTTTTAAATGTTGTGACCATTTAACCGTGTAAATATAAAATATTCTAGGCTTCTTCAC
AAATAATAGGGTAAAATAAATAATCGCCATAAGAGTGGTAGAAATAAATCTCCATGGCTCAGGCAAAGAGATTATTTTGCATCCTGGATA
CCAGCAATGCAAAATGGTATGAGATTTCTAAGGATTGATCACATTGGGATGGGAGATCAAGCAAAGAAATATTTGTAGAGGAGGGGAAAT
GGATCTATAGGGGATATACAGGGGGATGGATTTTCAAATTGGATTGATTCTAAGTTGAAATCTTGAAGAGAAGGTGTGGTGACAGTGGTT
AGGATGTTGTGGGTTCCTGACATAAAGTAGTTAAATGATATATCTTGGAGCTAACCTGTGTAAGTAAAGAACTAAGTAAGGAGATGACTA
AAAATGGAGTAGTTTCCTTTTTTATTTTTTTGAGACAGAGTCTCACTTTGTTTCCCAGGCTGGTGTGCAGTGGCACAATCTCGGCCCACT
GCAGCCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTTAGCCTCCTGAGTGGCTGGGATTACAGGGTTGTACCACCACACTCGGCTAA
CTTTTGTATTTTTGGTAGAGATGGGGTTTTGCCATGTTGGCTAGGCTGGTCTCAAACTCCTGGCCTCAAGTGATCTGCCCGCCTTGGCCT
CCCAAATTGCTGGGATTACAGGCGTGAGCCACCGCACCTGGCCAGTTTACTTTAAATGTGGTGTAGTCTCATGGTAAACTGAATTTGTCA
TCAGATGCAAAGTTCTATTCCCTAATGGAATGGAAGGAACACAAAACTTAAGAGTGAAATGGAATACTAAGATGTTTTTAAATAGGCAGG
ACTATGCTACTCACTTGAGGCTGGAGTGCCACCACTGCAAAATCTTTTTAAGTTTTGTAAAAAGGAGCATCTTGAATCCACTTAGATAAA
GACAGACTGTGTGTGTAGGTGGATTTTTCCCAAAGGATTTGGGAATTGTAATGTTACAATGAACTGTATGGATATGTTTGTCATGTACAT
TTTCAAACAAAAAGGAAAACTGAAAGTAGTGATCTTTGTATACCCATCTCTTAGATTCAGTGATTTTGCTATATAGGTTGTGTATCCCTT
ATCTGAAATACTTGGGACTAGTAGAAGCATCTTGGATTTGGGATGTTTTTCCAAATTTTGGAATACCTGCATACACACAATAAGATATCT
TGGAGATGGGACCCAAGTTTAAACACAAATTCACTTGTTTCATATATACCTTATGCACATAGCTTGAAGGTAACTTTATATAACATTATT
TTTAATAATTTTGTGCATTGAGACCAAGTTTGCATACCTTGAACCATCAGAAAGCAAAGGTGTCATTATCTCAGCCACTCATGTGGGTAA
TTTGTGGTTGGTTGATGTCACCATCATTCCTGACTGAATGTATATGCTACCAATAAGCAGTTATTTTCTTATACTTATTCATGCATAAGT
ACTTAACAGTAAAAAATATGACATAACTCGCACAGGAACAAGGATGGCAAAAAAAAAAATATGACACACCACTGATACAGTGAAAAAATA
ATGTGGTCAGGGTAGCTAGGCAACAGTAGCATCACCAGAAACCTGTATCAGCTGTTAAACGGCAACAACAATGGCAGGCTTTCAGTTTCC
CACTTAATGATGCTGTATTTTAAAAGGTTATTGTATACTGTAATTTTATTTTTGTAGGTGAAGAGAAACAGAAGCAGCTGAAGGGCCAGG
AAGTGGGTCTTTCTAGGGATGTGGCATTCTGCTGGATGGCTTTTTAAAATGGGTTTTTTCCTTTAGGGAGACCGAATAAACTGTGTTGTG

>99769_99769_1_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392132_RMDN1_chr8_87489553_ENST00000406452_length(amino acids)=470AA_BP=399
MPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTD
GTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIH
SLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIER
HSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMK
YKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFWLMKAKDYPAHTE

--------------------------------------------------------------
>99769_99769_2_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392132_RMDN1_chr8_87489553_ENST00000430676_length(transcript)=1665nt_BP=1253nt
ACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAAGCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACAC
GGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGAGGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTA
TGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTATAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGC
GACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAGTCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGT
ATCAGAACATCACAGTGCACAGACATCTGATGCTACCAGATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAAC
AGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATGTGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAA
TATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGCTGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCT
TCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGGACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCAC
TAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGATAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAA
TTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCTTCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTG
GCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGATTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCC
TAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCTTAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGT
TCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGGATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGG
GATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCATGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCCTTAG
GCTACTTTCACAGGGCAGAACAAGTGGATCCAAACTTCTACAGCAAAAACTTACTTCTTTTAGGAAAGACATACTTGAAACTACACAACA
AAAAGCTTGCTGCTTTCTGGCTAATGAAAGCCAAGGACTATCCAGCACACACAGAGGAGGATAAACAGATACAGACAGAAGCTGCTCAGT
TGCTTACAAGTTTCAGTGAGAAGAATTGAGAACTTTTCAGAGAAGATTTATGAAATAGCTAATAAACATTGCCTTTTCTTTTAATTCTAA
ACTTAATATATGAACTATAACTGTTCTACGGCTTTTTAAATGTTGTGACCATTTAACCGTGTAAATATAAAATATTCTAGGCTTCTTCAC

>99769_99769_2_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392132_RMDN1_chr8_87489553_ENST00000430676_length(amino acids)=470AA_BP=399
MPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTD
GTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIH
SLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIER
HSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMK
YKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFWLMKAKDYPAHTE

--------------------------------------------------------------
>99769_99769_3_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392132_RMDN1_chr8_87489553_ENST00000519966_length(transcript)=1717nt_BP=1253nt
ACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAAGCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACAC
GGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGAGGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTA
TGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTATAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGC
GACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAGTCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGT
ATCAGAACATCACAGTGCACAGACATCTGATGCTACCAGATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAAC
AGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATGTGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAA
TATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGCTGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCT
TCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGGACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCAC
TAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGATAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAA
TTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCTTCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTG
GCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGATTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCC
TAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCTTAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGT
TCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGGATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGG
GATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCATGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCCTTAG
GCTACTTTCACAGGGCAGAACAAGGAAAGACATACTTGAAACTACACAACAAAAAGCTTGCTGCTTTCTGGCTAATGAAAGCCAAGGACT
ATCCAGCACACACAGAGGAGGATAAACAGATACAGACAGAAGCTGCTCAGTTGCTTACAAGTTTCAGTGAGAAGAATTGAGAACTTTTCA
GAGAAGATTTATGAAATAGCTAATAAACATTGCCTTTTCTTTTAATTCTAAACTTAATATATGAACTATAACTGTTCTACGGCTTTTTAA
ATGTTGTGACCATTTAACCGTGTAAATATAAAATATTCTAGGCTTCTTCACAAATAATAGGGTAAAATAAATAATCGCCATAAGAGTGGT
AGAAATAAATCTCCATGGCTCAGGCAAAGAGATTATTTTGCATCCTGGATACCAGCAATGCAAAATGGTATGAGATTTCTAAGGATTGAT

>99769_99769_3_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392132_RMDN1_chr8_87489553_ENST00000519966_length(amino acids)=457AA_BP=399
MPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTD
GTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIH
SLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIER
HSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMK
YKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEALGYFHRAEQGKTYLKLHNKKLAAFWLMKAKDYPAHTEEDKQIQTEAAQLL

--------------------------------------------------------------
>99769_99769_4_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392132_RMDN1_chr8_87489553_ENST00000523911_length(transcript)=1506nt_BP=1253nt
ACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAAGCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACAC
GGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGAGGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTA
TGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTATAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGC
GACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAGTCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGT
ATCAGAACATCACAGTGCACAGACATCTGATGCTACCAGATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAAC
AGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATGTGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAA
TATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGCTGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCT
TCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGGACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCAC
TAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGATAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAA
TTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCTTCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTG
GCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGATTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCC
TAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCTTAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGT
TCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGGATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGG
GATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCATGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCCTTAG
GCTACTTTCACAGGGCAGAACAAGGAAAGACATACTTGAAACTACACAACAAAAAGCTTGCTGCTTTCTGGCTAATGAAAGCCAAGGACT
ATCCAGCACACACAGAGGAGGATAAACAGGTGAAGAGAAACAGAAGCAGCTGAAGGGCCAGGAAGTGGGTCTTTCTAGGGATGTGGCATT

>99769_99769_4_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392132_RMDN1_chr8_87489553_ENST00000523911_length(amino acids)=448AA_BP=399
MPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTD
GTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIH
SLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIER
HSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMK

--------------------------------------------------------------
>99769_99769_5_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392133_RMDN1_chr8_87489553_ENST00000406452_length(transcript)=3748nt_BP=1574nt
AGAAACCCCACAAAAATTAGCTGGGCTTGGTGGCACACACCTGTGGTCCCAGCTACCTGGGAGGCTGAGCTCTGGATCGTACAAGAAGGG
AGACAAGGACCACTGACAAGATATGCGTTTCAGGCGGCTCAAACACCACACGCTCCCGACTACGGCGGAATGGAGAGAATGTGCGCATGC
TCGGCGGGAATCTGCGCATGCTCGGCGGGAATCTGCGCATGCTCGGAGAGAATCTGCGCATGCTCGGCCGGAATCTGCGCGAGCTCGGCG
GGAATCTGCGCAAGCTCGGCGGGAATCTGCGCATGCTCAGAGTTCCGGGGCACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAA
GCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACACGGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGA
GGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTATGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTA
TAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGCGACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAG
TCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGTATCAGAACATCACAGTGCACAGACATCTGATGCTACCAG
ATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAACAGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATG
TGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAATATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGC
TGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCTTCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGG
ACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCACTAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGA
TAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAATTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCT
TCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTGGCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGA
TTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCCTAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCT
TAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGTTCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGG
ATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGGGATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCA
TGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCCTTAGGCTACTTTCACAGGGCAGAACAAGTGGATCCAAACTTCT
ACAGCAAAAACTTACTTCTTTTAGGAAAGACATACTTGAAACTACACAACAAAAAGCTTGCTGCTTTCTGGCTAATGAAAGCCAAGGACT
ATCCAGCACACACAGAGGAGGATAAACAGATACAGACAGAAGCTGCTCAGTTGCTTACAAGTTTCAGTGAGAAGAATTGAGAACTTTTCA
GAGAAGATTTATGAAATAGCTAATAAACATTGCCTTTTCTTTTAATTCTAAACTTAATATATGAACTATAACTGTTCTACGGCTTTTTAA
ATGTTGTGACCATTTAACCGTGTAAATATAAAATATTCTAGGCTTCTTCACAAATAATAGGGTAAAATAAATAATCGCCATAAGAGTGGT
AGAAATAAATCTCCATGGCTCAGGCAAAGAGATTATTTTGCATCCTGGATACCAGCAATGCAAAATGGTATGAGATTTCTAAGGATTGAT
CACATTGGGATGGGAGATCAAGCAAAGAAATATTTGTAGAGGAGGGGAAATGGATCTATAGGGGATATACAGGGGGATGGATTTTCAAAT
TGGATTGATTCTAAGTTGAAATCTTGAAGAGAAGGTGTGGTGACAGTGGTTAGGATGTTGTGGGTTCCTGACATAAAGTAGTTAAATGAT
ATATCTTGGAGCTAACCTGTGTAAGTAAAGAACTAAGTAAGGAGATGACTAAAAATGGAGTAGTTTCCTTTTTTATTTTTTTGAGACAGA
GTCTCACTTTGTTTCCCAGGCTGGTGTGCAGTGGCACAATCTCGGCCCACTGCAGCCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCT
TAGCCTCCTGAGTGGCTGGGATTACAGGGTTGTACCACCACACTCGGCTAACTTTTGTATTTTTGGTAGAGATGGGGTTTTGCCATGTTG
GCTAGGCTGGTCTCAAACTCCTGGCCTCAAGTGATCTGCCCGCCTTGGCCTCCCAAATTGCTGGGATTACAGGCGTGAGCCACCGCACCT
GGCCAGTTTACTTTAAATGTGGTGTAGTCTCATGGTAAACTGAATTTGTCATCAGATGCAAAGTTCTATTCCCTAATGGAATGGAAGGAA
CACAAAACTTAAGAGTGAAATGGAATACTAAGATGTTTTTAAATAGGCAGGACTATGCTACTCACTTGAGGCTGGAGTGCCACCACTGCA
AAATCTTTTTAAGTTTTGTAAAAAGGAGCATCTTGAATCCACTTAGATAAAGACAGACTGTGTGTGTAGGTGGATTTTTCCCAAAGGATT
TGGGAATTGTAATGTTACAATGAACTGTATGGATATGTTTGTCATGTACATTTTCAAACAAAAAGGAAAACTGAAAGTAGTGATCTTTGT
ATACCCATCTCTTAGATTCAGTGATTTTGCTATATAGGTTGTGTATCCCTTATCTGAAATACTTGGGACTAGTAGAAGCATCTTGGATTT
GGGATGTTTTTCCAAATTTTGGAATACCTGCATACACACAATAAGATATCTTGGAGATGGGACCCAAGTTTAAACACAAATTCACTTGTT
TCATATATACCTTATGCACATAGCTTGAAGGTAACTTTATATAACATTATTTTTAATAATTTTGTGCATTGAGACCAAGTTTGCATACCT
TGAACCATCAGAAAGCAAAGGTGTCATTATCTCAGCCACTCATGTGGGTAATTTGTGGTTGGTTGATGTCACCATCATTCCTGACTGAAT
GTATATGCTACCAATAAGCAGTTATTTTCTTATACTTATTCATGCATAAGTACTTAACAGTAAAAAATATGACATAACTCGCACAGGAAC
AAGGATGGCAAAAAAAAAAATATGACACACCACTGATACAGTGAAAAAATAATGTGGTCAGGGTAGCTAGGCAACAGTAGCATCACCAGA
AACCTGTATCAGCTGTTAAACGGCAACAACAATGGCAGGCTTTCAGTTTCCCACTTAATGATGCTGTATTTTAAAAGGTTATTGTATACT
GTAATTTTATTTTTGTAGGTGAAGAGAAACAGAAGCAGCTGAAGGGCCAGGAAGTGGGTCTTTCTAGGGATGTGGCATTCTGCTGGATGG

>99769_99769_5_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392133_RMDN1_chr8_87489553_ENST00000406452_length(amino acids)=572AA_BP=501
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAEN
KDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSS
RFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSES
LRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDI
VPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFW

--------------------------------------------------------------
>99769_99769_6_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392133_RMDN1_chr8_87489553_ENST00000430676_length(transcript)=1986nt_BP=1574nt
AGAAACCCCACAAAAATTAGCTGGGCTTGGTGGCACACACCTGTGGTCCCAGCTACCTGGGAGGCTGAGCTCTGGATCGTACAAGAAGGG
AGACAAGGACCACTGACAAGATATGCGTTTCAGGCGGCTCAAACACCACACGCTCCCGACTACGGCGGAATGGAGAGAATGTGCGCATGC
TCGGCGGGAATCTGCGCATGCTCGGCGGGAATCTGCGCATGCTCGGAGAGAATCTGCGCATGCTCGGCCGGAATCTGCGCGAGCTCGGCG
GGAATCTGCGCAAGCTCGGCGGGAATCTGCGCATGCTCAGAGTTCCGGGGCACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAA
GCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACACGGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGA
GGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTATGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTA
TAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGCGACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAG
TCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGTATCAGAACATCACAGTGCACAGACATCTGATGCTACCAG
ATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAACAGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATG
TGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAATATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGC
TGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCTTCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGG
ACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCACTAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGA
TAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAATTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCT
TCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTGGCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGA
TTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCCTAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCT
TAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGTTCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGG
ATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGGGATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCA
TGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCCTTAGGCTACTTTCACAGGGCAGAACAAGTGGATCCAAACTTCT
ACAGCAAAAACTTACTTCTTTTAGGAAAGACATACTTGAAACTACACAACAAAAAGCTTGCTGCTTTCTGGCTAATGAAAGCCAAGGACT
ATCCAGCACACACAGAGGAGGATAAACAGATACAGACAGAAGCTGCTCAGTTGCTTACAAGTTTCAGTGAGAAGAATTGAGAACTTTTCA
GAGAAGATTTATGAAATAGCTAATAAACATTGCCTTTTCTTTTAATTCTAAACTTAATATATGAACTATAACTGTTCTACGGCTTTTTAA
ATGTTGTGACCATTTAACCGTGTAAATATAAAATATTCTAGGCTTCTTCACAAATAATAGGGTAAAATAAATAATCGCCATAAGAGTGGT

>99769_99769_6_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392133_RMDN1_chr8_87489553_ENST00000430676_length(amino acids)=572AA_BP=501
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAEN
KDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSS
RFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSES
LRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDI
VPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFW

--------------------------------------------------------------
>99769_99769_7_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392133_RMDN1_chr8_87489553_ENST00000519966_length(transcript)=2038nt_BP=1574nt
AGAAACCCCACAAAAATTAGCTGGGCTTGGTGGCACACACCTGTGGTCCCAGCTACCTGGGAGGCTGAGCTCTGGATCGTACAAGAAGGG
AGACAAGGACCACTGACAAGATATGCGTTTCAGGCGGCTCAAACACCACACGCTCCCGACTACGGCGGAATGGAGAGAATGTGCGCATGC
TCGGCGGGAATCTGCGCATGCTCGGCGGGAATCTGCGCATGCTCGGAGAGAATCTGCGCATGCTCGGCCGGAATCTGCGCGAGCTCGGCG
GGAATCTGCGCAAGCTCGGCGGGAATCTGCGCATGCTCAGAGTTCCGGGGCACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAA
GCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACACGGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGA
GGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTATGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTA
TAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGCGACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAG
TCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGTATCAGAACATCACAGTGCACAGACATCTGATGCTACCAG
ATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAACAGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATG
TGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAATATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGC
TGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCTTCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGG
ACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCACTAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGA
TAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAATTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCT
TCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTGGCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGA
TTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCCTAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCT
TAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGTTCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGG
ATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGGGATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCA
TGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCCTTAGGCTACTTTCACAGGGCAGAACAAGGAAAGACATACTTGA
AACTACACAACAAAAAGCTTGCTGCTTTCTGGCTAATGAAAGCCAAGGACTATCCAGCACACACAGAGGAGGATAAACAGATACAGACAG
AAGCTGCTCAGTTGCTTACAAGTTTCAGTGAGAAGAATTGAGAACTTTTCAGAGAAGATTTATGAAATAGCTAATAAACATTGCCTTTTC
TTTTAATTCTAAACTTAATATATGAACTATAACTGTTCTACGGCTTTTTAAATGTTGTGACCATTTAACCGTGTAAATATAAAATATTCT
AGGCTTCTTCACAAATAATAGGGTAAAATAAATAATCGCCATAAGAGTGGTAGAAATAAATCTCCATGGCTCAGGCAAAGAGATTATTTT

>99769_99769_7_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392133_RMDN1_chr8_87489553_ENST00000519966_length(amino acids)=559AA_BP=501
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAEN
KDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSS
RFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSES
LRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDI
VPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEALGYFHRAEQGKTYLKLHNKKLAAFWLMKAKDYPAHTEE

--------------------------------------------------------------
>99769_99769_8_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392133_RMDN1_chr8_87489553_ENST00000523911_length(transcript)=1827nt_BP=1574nt
AGAAACCCCACAAAAATTAGCTGGGCTTGGTGGCACACACCTGTGGTCCCAGCTACCTGGGAGGCTGAGCTCTGGATCGTACAAGAAGGG
AGACAAGGACCACTGACAAGATATGCGTTTCAGGCGGCTCAAACACCACACGCTCCCGACTACGGCGGAATGGAGAGAATGTGCGCATGC
TCGGCGGGAATCTGCGCATGCTCGGCGGGAATCTGCGCATGCTCGGAGAGAATCTGCGCATGCTCGGCCGGAATCTGCGCGAGCTCGGCG
GGAATCTGCGCAAGCTCGGCGGGAATCTGCGCATGCTCAGAGTTCCGGGGCACGGTTTCCCCGCCCCTTTCAGGCCTAGCAGGAAACGAA
GCGGCTCTTTCCGCTATCTGCCGCTTGTCCACCGGAAGCGAGTTGCGACACGGCAGGTTCCCGCCCGGAAGAAGCGACCAAAGCGCCTGA
GGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTATGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTA
TAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGCGACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAG
TCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGTATCAGAACATCACAGTGCACAGACATCTGATGCTACCAG
ATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAACAGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATG
TGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAATATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGC
TGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCTTCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGG
ACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCACTAAAAGGAATTACCGAACAGCAAAAAGAAGGTCTTGAGA
TAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGGTTGGATGAAATTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCT
TCAAGAAAATTGAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTGGCTCCAATTTGTCTATAAGGATTGCAGCCTATAAATCGA
TTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGATGCAAAAACCCTAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCT
TAAATGATGATGATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGTTCCGCTATGGAAGTGATATAGTTCCTTTCTCTAAAGTGG
ATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTCTCTGTTTTGGGATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCA
TGGGAAATCAAGTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCCTTAGGCTACTTTCACAGGGCAGAACAAGGAAAGACATACTTGA
AACTACACAACAAAAAGCTTGCTGCTTTCTGGCTAATGAAAGCCAAGGACTATCCAGCACACACAGAGGAGGATAAACAGGTGAAGAGAA
ACAGAAGCAGCTGAAGGGCCAGGAAGTGGGTCTTTCTAGGGATGTGGCATTCTGCTGGATGGCTTTTTAAAATGGGTTTTTTCCTTTAGG

>99769_99769_8_XRCC5-RMDN1_XRCC5_chr2_216997110_ENST00000392133_RMDN1_chr8_87489553_ENST00000523911_length(amino acids)=550AA_BP=501
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAEN
KDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSS
RFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSES
LRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDI
VPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEALGYFHRAEQGKTYLKLHNKKLAAFWLMKAKDYPAHTEE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for XRCC5-RMDN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for XRCC5-RMDN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for XRCC5-RMDN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource