FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:YAP1-STIM1 (FusionGDB2 ID:99893)

Fusion Gene Summary for YAP1-STIM1

check button Fusion gene summary
Fusion gene informationFusion gene name: YAP1-STIM1
Fusion gene ID: 99893
HgeneTgene
Gene symbol

YAP1

STIM1

Gene ID

10413

6786

Gene nameYes1 associated transcriptional regulatorstromal interaction molecule 1
SynonymsCOB1|YAP|YAP2|YAP65|YKID11S4896E|GOK|IMD10|STRMK|TAM|TAM1
Cytomap

11q22.1

11p15.4

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional coactivator YAP165 kDa Yes-associated proteinYes associated protein 1protein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homologstromal interaction molecule 1
Modification date2020032920200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000282441, ENST00000524575, 
ENST00000345877, ENST00000526343, 
ENST00000528834, ENST00000531439, 
ENST00000537274, 		ENST00000527484, 
ENST00000533977, ENST00000300737, 
ENST00000527651, 
Fusion gene scores* DoF score23 X 13 X 14=418611 X 11 X 4=484
# samples 2512
** MAII scorelog2(25/4186*10)=-4.06557231159362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/484*10)=-2.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YAP1 [Title/Abstract] AND STIM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointYAP1(102080295)-STIM1(4045103), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYAP1

GO:0006974

cellular response to DNA damage stimulus

18280240

HgeneYAP1

GO:0008283

cell proliferation

17974916

HgeneYAP1

GO:0032570

response to progesterone

16772533

HgeneYAP1

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

16772533

HgeneYAP1

GO:0045893

positive regulation of transcription, DNA-templated

20368466

HgeneYAP1

GO:0045944

positive regulation of transcription by RNA polymerase II

25796446

HgeneYAP1

GO:0050767

regulation of neurogenesis

25433207

HgeneYAP1

GO:0050847

progesterone receptor signaling pathway

16772533

HgeneYAP1

GO:0060242

contact inhibition

17974916

HgeneYAP1

GO:0065003

protein-containing complex assembly

20368466

HgeneYAP1

GO:0071480

cellular response to gamma radiation

18280240

HgeneYAP1

GO:0072091

regulation of stem cell proliferation

25433207

TgeneSTIM1

GO:0002115

store-operated calcium entry

28219928

TgeneSTIM1

GO:0005513

detection of calcium ion

16005298

TgeneSTIM1

GO:0032237

activation of store-operated calcium channel activity

16005298|26322679|28219928

TgeneSTIM1

GO:0045762

positive regulation of adenylate cyclase activity

19171672

TgeneSTIM1

GO:0051924

regulation of calcium ion transport

16005298


check buttonFusion gene breakpoints across YAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STIM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A086-01AYAP1chr11

102080295

-STIM1chr11

4045103

+
ChimerDB4BRCATCGA-A8-A086-01AYAP1chr11

102080295

+STIM1chr11

4045103

+


Top

Fusion Gene ORF analysis for YAP1-STIM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000282441ENST00000527484YAP1chr11

102080295

+STIM1chr11

4045103

+
5CDS-3UTRENST00000524575ENST00000527484YAP1chr11

102080295

+STIM1chr11

4045103

+
5CDS-intronENST00000282441ENST00000533977YAP1chr11

102080295

+STIM1chr11

4045103

+
5CDS-intronENST00000524575ENST00000533977YAP1chr11

102080295

+STIM1chr11

4045103

+
In-frameENST00000282441ENST00000300737YAP1chr11

102080295

+STIM1chr11

4045103

+
In-frameENST00000282441ENST00000527651YAP1chr11

102080295

+STIM1chr11

4045103

+
In-frameENST00000524575ENST00000300737YAP1chr11

102080295

+STIM1chr11

4045103

+
In-frameENST00000524575ENST00000527651YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3CDSENST00000345877ENST00000300737YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3CDSENST00000345877ENST00000527651YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3CDSENST00000526343ENST00000300737YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3CDSENST00000526343ENST00000527651YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3CDSENST00000528834ENST00000300737YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3CDSENST00000528834ENST00000527651YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3CDSENST00000531439ENST00000300737YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3CDSENST00000531439ENST00000527651YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3CDSENST00000537274ENST00000300737YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3CDSENST00000537274ENST00000527651YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3UTRENST00000345877ENST00000527484YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3UTRENST00000526343ENST00000527484YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3UTRENST00000528834ENST00000527484YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3UTRENST00000531439ENST00000527484YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-3UTRENST00000537274ENST00000527484YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-intronENST00000345877ENST00000533977YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-intronENST00000526343ENST00000533977YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-intronENST00000528834ENST00000533977YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-intronENST00000531439ENST00000533977YAP1chr11

102080295

+STIM1chr11

4045103

+
intron-intronENST00000537274ENST00000533977YAP1chr11

102080295

+STIM1chr11

4045103

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000282441YAP1chr11102080295+ENST00000300737STIM1chr114045103+461914203883207939
ENST00000282441YAP1chr11102080295+ENST00000527651STIM1chr114045103+324514203882772794
ENST00000524575YAP1chr11102080295+ENST00000300737STIM1chr114045103+41429432622730822
ENST00000524575YAP1chr11102080295+ENST00000527651STIM1chr114045103+27689432622295677

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282441ENST00000300737YAP1chr11102080295+STIM1chr114045103+0.0048382280.99516183
ENST00000282441ENST00000527651YAP1chr11102080295+STIM1chr114045103+0.030855450.9691445
ENST00000524575ENST00000300737YAP1chr11102080295+STIM1chr114045103+0.0061554560.9938445
ENST00000524575ENST00000527651YAP1chr11102080295+STIM1chr114045103+0.025574280.97442573

Top

Fusion Genomic Features for YAP1-STIM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
YAP1chr11102080295+STIM1chr114045102+4.27E-050.9999573
YAP1chr11102080295+STIM1chr114045102+4.27E-050.9999573

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for YAP1-STIM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:102080295/chr11:4045103)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneYAP1chr11:102080295chr11:4045103ENST00000282441+6986_100344505.0Coiled coilOntology_term=ECO:0000269
HgeneYAP1chr11:102080295chr11:4045103ENST00000524575+6986_100166327.0Coiled coilOntology_term=ECO:0000269
HgeneYAP1chr11:102080295chr11:4045103ENST00000282441+693_49344505.0Compositional biasNote=Pro-rich
HgeneYAP1chr11:102080295chr11:4045103ENST00000524575+693_49166327.0Compositional biasNote=Pro-rich
HgeneYAP1chr11:102080295chr11:4045103ENST00000282441+69171_204344505.0DomainWW 1
HgeneYAP1chr11:102080295chr11:4045103ENST00000282441+69230_263344505.0DomainWW 2
TgeneSTIM1chr11:102080295chr11:4045103ENST00000300737112248_44290686.0Coiled coilOntology_term=ECO:0000269,ECO:0000269,ECO:0000269
TgeneSTIM1chr11:102080295chr11:4045103ENST00000300737112270_33690686.0Compositional biasNote=Glu-rich
TgeneSTIM1chr11:102080295chr11:4045103ENST00000300737112600_62990686.0Compositional biasNote=Pro/Ser-rich
TgeneSTIM1chr11:102080295chr11:4045103ENST00000300737112672_68590686.0Compositional biasNote=Lys-rich
TgeneSTIM1chr11:102080295chr11:4045103ENST00000300737112132_20090686.0DomainSAM
TgeneSTIM1chr11:102080295chr11:4045103ENST00000300737112642_64590686.0MotifNote=Microtubule tip localization signal
TgeneSTIM1chr11:102080295chr11:4045103ENST00000300737112334_44490686.0RegionNote=SOAR/CAD
TgeneSTIM1chr11:102080295chr11:4045103ENST00000300737112235_68590686.0Topological domainCytoplasmic
TgeneSTIM1chr11:102080295chr11:4045103ENST00000300737112214_23490686.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneYAP1chr11:102080295chr11:4045103ENST00000282441+69298_359344505.0Coiled coilOntology_term=ECO:0000255
HgeneYAP1chr11:102080295chr11:4045103ENST00000345877+17298_3590455.0Coiled coilOntology_term=ECO:0000255
HgeneYAP1chr11:102080295chr11:4045103ENST00000345877+1786_1000455.0Coiled coilOntology_term=ECO:0000269
HgeneYAP1chr11:102080295chr11:4045103ENST00000524575+69298_359166327.0Coiled coilOntology_term=ECO:0000255
HgeneYAP1chr11:102080295chr11:4045103ENST00000526343+17298_3590451.0Coiled coilOntology_term=ECO:0000255
HgeneYAP1chr11:102080295chr11:4045103ENST00000526343+1786_1000451.0Coiled coilOntology_term=ECO:0000269
HgeneYAP1chr11:102080295chr11:4045103ENST00000531439+18298_3590489.0Coiled coilOntology_term=ECO:0000255
HgeneYAP1chr11:102080295chr11:4045103ENST00000531439+1886_1000489.0Coiled coilOntology_term=ECO:0000269
HgeneYAP1chr11:102080295chr11:4045103ENST00000537274+18298_3590493.0Coiled coilOntology_term=ECO:0000255
HgeneYAP1chr11:102080295chr11:4045103ENST00000537274+1886_1000493.0Coiled coilOntology_term=ECO:0000269
HgeneYAP1chr11:102080295chr11:4045103ENST00000345877+173_490455.0Compositional biasNote=Pro-rich
HgeneYAP1chr11:102080295chr11:4045103ENST00000526343+173_490451.0Compositional biasNote=Pro-rich
HgeneYAP1chr11:102080295chr11:4045103ENST00000531439+183_490489.0Compositional biasNote=Pro-rich
HgeneYAP1chr11:102080295chr11:4045103ENST00000537274+183_490493.0Compositional biasNote=Pro-rich
HgeneYAP1chr11:102080295chr11:4045103ENST00000345877+17171_2040455.0DomainWW 1
HgeneYAP1chr11:102080295chr11:4045103ENST00000345877+17230_2630455.0DomainWW 2
HgeneYAP1chr11:102080295chr11:4045103ENST00000524575+69171_204166327.0DomainWW 1
HgeneYAP1chr11:102080295chr11:4045103ENST00000524575+69230_263166327.0DomainWW 2
HgeneYAP1chr11:102080295chr11:4045103ENST00000526343+17171_2040451.0DomainWW 1
HgeneYAP1chr11:102080295chr11:4045103ENST00000526343+17230_2630451.0DomainWW 2
HgeneYAP1chr11:102080295chr11:4045103ENST00000531439+18171_2040489.0DomainWW 1
HgeneYAP1chr11:102080295chr11:4045103ENST00000531439+18230_2630489.0DomainWW 2
HgeneYAP1chr11:102080295chr11:4045103ENST00000537274+18171_2040493.0DomainWW 1
HgeneYAP1chr11:102080295chr11:4045103ENST00000537274+18230_2630493.0DomainWW 2
HgeneYAP1chr11:102080295chr11:4045103ENST00000282441+69291_504344505.0RegionNote=Transactivation domain
HgeneYAP1chr11:102080295chr11:4045103ENST00000345877+17291_5040455.0RegionNote=Transactivation domain
HgeneYAP1chr11:102080295chr11:4045103ENST00000524575+69291_504166327.0RegionNote=Transactivation domain
HgeneYAP1chr11:102080295chr11:4045103ENST00000526343+17291_5040451.0RegionNote=Transactivation domain
HgeneYAP1chr11:102080295chr11:4045103ENST00000531439+18291_5040489.0RegionNote=Transactivation domain
HgeneYAP1chr11:102080295chr11:4045103ENST00000537274+18291_5040493.0RegionNote=Transactivation domain
TgeneSTIM1chr11:102080295chr11:4045103ENST0000030073711276_8790686.0Calcium binding.
TgeneSTIM1chr11:102080295chr11:4045103ENST0000030073711263_9890686.0DomainNote=EF-hand
TgeneSTIM1chr11:102080295chr11:4045103ENST0000030073711223_21390686.0Topological domainExtracellular


Top

Fusion Gene Sequence for YAP1-STIM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99893_99893_1_YAP1-STIM1_YAP1_chr11_102080295_ENST00000282441_STIM1_chr11_4045103_ENST00000300737_length(transcript)=4619nt_BP=1420nt
GCCGCCGCCAGGGAAAAGAAAGGGAGGAAGGAAGGAACAAGAAAAGGAAATAAAGAGAAAGGGGAGGCGGGGAAAGGCAACGAGCTGTCC
GGCCTCCGTCAAGGGAGTTGGAGGGAAAAAGTTCTCAGGCGCCGCAGGTCCGAGTGCCTCGCAGCCCCTCCCGAGGCGCAGCCGCCAGAC
CAGTGGAGCCGGGGCGCAGGGCGGGGGCGGAGGCGCCGGGGCGGGGGATGCGGGGCCGCGGCGCAGCCCCCCGGCCCTGAGAGCGAGGAC
AGCGCCGCCCGGCCCGCAGCCGTCGCCGCTTCTCCACCTCGGCCCGTGGAGCCGGGGCGTCCGGGCGTAGCCCTCGCTCGCCTGGGTCAG
GGGGTGCGCGTCGGGGGAGGCAGAAGCCATGGATCCCGGGCAGCAGCCGCCGCCTCAACCGGCCCCCCAGGGCCAAGGGCAGCCGCCTTC
GCAGCCCCCGCAGGGGCAGGGCCCGCCGTCCGGACCCGGGCAACCGGCACCCGCGGCGACCCAGGCGGCGCCGCAGGCACCCCCCGCCGG
GCATCAGATCGTGCACGTCCGCGGGGACTCGGAGACCGACCTGGAGGCGCTCTTCAACGCCGTCATGAACCCCAAGACGGCCAACGTGCC
CCAGACCGTGCCCATGAGGCTCCGGAAGCTGCCCGACTCCTTCTTCAAGCCGCCGGAGCCCAAATCCCACTCCCGACAGGCCAGTACTGA
TGCAGGCACTGCAGGAGCCCTGACTCCACAGCATGTTCGAGCTCATTCCTCTCCAGCTTCTCTGCAGTTGGGAGCTGTTTCTCCTGGGAC
ACTGACCCCCACTGGAGTAGTCTCTGGCCCAGCAGCTACACCCACAGCTCAGCATCTTCGACAGTCTTCTTTTGAGATACCTGATGATGT
ACCTCTGCCAGCAGGTTGGGAGATGGCAAAGACATCTTCTGGTCAGAGATACTTCTTAAATCACATCGATCAGACAACAACATGGCAGGA
CCCCAGGAAGGCCATGCTGTCCCAGATGAACGTCACAGCCCCCACCAGTCCACCAGTGCAGCAGAATATGATGAACTCGGCTTCAGGTCC
TCTTCCTGATGGATGGGAACAAGCCATGACTCAGGATGGAGAAATTTACTATATAAACCATAAGAACAAGACCACCTCTTGGCTAGACCC
AAGGCTTGACCCTCGTTTTGCCATGAACCAGAGAATCAGTCAGAGTGCTCCAGTGAAACAGCCACCACCCCTGGCTCCCCAGAGCCCACA
GGGAGGCGTCATGGGTGGCAGCAACTCCAACCAGCAGCAACAGATGCGACTGCAGCAACTGCAGATGGAGAAGGAGAGGCTGCGGCTGAA
ACAGCAAGAACTGCTTCGGCAGGCAATGCGGAATATCAATCCCAGCACAGCAAATTCTCCAAAATGTCAGTTCCTGAGGGAAGACCTCAA
TTACCATGACCCAACAGTGAAACACAGCACCTTCCATGGTGAGGATAAGCTCATCAGCGTGGAGGACCTGTGGAAGGCATGGAAGTCATC
AGAAGTATACAATTGGACCGTGGATGAGGTGGTACAGTGGCTGATCACATATGTGGAGCTGCCTCAGTATGAGGAGACCTTCCGGAAGCT
GCAGCTCAGTGGCCATGCCATGCCAAGGCTGGCTGTCACCAACACCACCATGACAGGGACTGTGCTGAAGATGACAGACCGGAGTCATCG
GCAGAAGCTGCAGCTGAAGGCTCTGGATACAGTGCTCTTTGGGCCTCCTCTCTTGACTCGCCATAATCACCTCAAGGACTTCATGCTGGT
GGTGTCTATCGTTATTGGTGTGGGCGGCTGCTGGTTTGCCTATATCCAGAACCGTTACTCCAAGGAGCACATGAAGAAGATGATGAAGGA
CTTGGAGGGGTTACACCGAGCTGAGCAGAGTCTGCATGACCTTCAGGAAAGGCTGCACAAGGCCCAGGAGGAGCACCGCACAGTGGAGGT
GGAGAAGGTCCATCTGGAAAAGAAGCTGCGCGATGAGATCAACCTTGCTAAGCAGGAAGCCCAGCGGCTGAAGGAGCTGCGGGAGGGTAC
TGAGAATGAGCGGAGCCGCCAAAAATATGCTGAGGAGGAGTTGGAGCAGGTTCGGGAGGCCTTGAGGAAAGCAGAGAAGGAGCTAGAATC
TCACAGCTCATGGTATGCTCCAGAGGCCCTTCAGAAGTGGCTGCAGCTGACACATGAGGTGGAGGTGCAATATTACAACATCAAGAAGCA
AAATGCTGAGAAGCAGCTGCTGGTGGCCAAGGAGGGGGCTGAGAAGATAAAAAAGAAGAGAAACACACTCTTTGGCACCTTCCACGTGGC
CCACAGCTCTTCCCTGGATGATGTAGATCATAAAATTCTAACAGCTAAGCAAGCACTGAGCGAGGTGACAGCAGCATTGCGGGAGCGCCT
GCACCGCTGGCAACAGATCGAGATCCTCTGTGGCTTCCAGATTGTCAACAACCCTGGCATCCACTCACTGGTGGCTGCCCTCAACATAGA
CCCCAGCTGGATGGGCAGTACACGCCCCAACCCTGCTCACTTCATCATGACTGACGACGTGGATGACATGGATGAGGAGATTGTGTCTCC
CTTGTCCATGCAGTCCCCTAGCCTGCAGAGCAGTGTTCGGCAGCGCCTGACGGAGCCACAGCATGGCCTGGGATCTCAGAGGGATTTGAC
CCATTCCGATTCGGAGTCCTCCCTCCACATGAGTGACCGCCAGCGTGTGGCCCCCAAACCTCCTCAGATGAGCCGTGCTGCAGACGAGGC
TCTCAATGCCATGACTTCCAATGGCAGCCACCGGCTGATCGAGGGGGTCCACCCAGGGTCTCTGGTGGAGAAACTGCCTGACAGCCCTGC
CCTGGCCAAGAAGGCATTACTGGCGCTGAACCATGGGCTGGACAAGGCCCACAGCCTGATGGAGCTGAGCCCCTCAGCCCCACCTGGTGG
CTCTCCACATTTGGATTCTTCCCGTTCTCACAGCCCCAGCTCCCCAGACCCAGACACACCATCTCCAGTTGGGGACAGCCGAGCCCTGCA
AGCCAGCCGAAACACACGCATTCCCCACCTGGCTGGCAAGAAGGCTGTGGCTGAGGAGGATAATGGCTCTATTGGCGAGGAAACAGACTC
CAGCCCAGGCCGGAAGAAGTTTCCCCTCAAAATCTTTAAGAAGCCTCTTAAGAAGTAGGCAGGATGGGGTGGCAGTAAAGGGACAGCTTG
TCCTTCCCTGGGTGTTCTGTCTCTCCTTCCCTCCCTTCCTTCAAGATAACTGGCCCCAAGAGTGGGGCATGGGAAGGGCTGGTCCAGGGG
TCTGGGCACTGTACATACCTGCCCCCTCATCCTTGGGTCCTTCATTATTATTTATTAACTGACCACCATGGCCTGCCTGCCCTGCCTCCG
TCCCAACCATGGGCTGCTGCTGTCACTCCCTCTCCACTTCAGTGCATGTCTTAGTTGCTGTTCCCTCAGCTCCCAGCTCCACCTCTGGGG
TTCAGCTTCTGTCTCTGCTGTCCCAGTTTTGAGGTTTGGTTTCTTGTTTCTGTCTCTTGCTTTCGGGCTCCTCCCTCCCACCACTCCCCA
ACTTCCCCTAGCAGTTGCAGGGAAGATAGGACGAGTAGCTTCTGACATGTGTGCCTCAGATCTGTTCCACCCCACTCACAGTGGTTCTGT
TTGCTCCAGACTGGGGCTAGGGCCTAATCTTTGAAGTTTGTTCTTTGGTATTGATGTGGGTCAGAAGGAGCCTCATCCTAATCTCACTCA
GGCCTCCAGGGATCCATGGGGGAGTGAAACCAATTCTCAGAGAACAACCCACCAGAGACTTTTAAAGAGAGGCCAGGCTTGGGAATGGGT
TGGGAGAGGCATCTGTTCATTGGAGCATGAGTGGATGCCAGAACTGTAGGTTATAAGGCAGTCACTTTTTCTCTCTACTCCCACCCACAC
CTGCCTCCCTCTTACCCCTGCTCCCCCACACTGCAGGAGGATTTGTCTCTAAGAGGTGCTGCCCCAAAGCTCCCCAAGCATCAATACTCC
TAGGGCTCAGGACAAGTGGCTCCCCTGGCCAGGAGAGCCACAGCCATGATACAGGGCTCTTATGGAGCCCTGGAGTTGTTGGGCAAGGAT
GCTGTCATTTTTTGAACCAAAAGACAAACAGGTTAAAAGGAAAAAAAGTAATCTGAATTTCCCAAGTGCCTACGCTGCATATTCCCCTTG
TTAGATCCCATTTTCATGTTACTTTGTAGCCTTGGCCAGAGGCTCAAAAAGGACACAACCAGTTTGGGGAAGGGGTGGCTAAGGAAGATG
GTATAGGTGAAGGCGGCTGTGTGACCACTTTCCCCCACCCTTCCCACCCTCTAGACAACTCTCTCCCTTACCTGTTTTTGCTATGGCTGT
AAAGGTATTTTTCCTCTGCCCCACTCCCTGCCATACCTTTATCCTGGGATCCTATTTTGGGCCTGGGGTGGGTATACCTGGGGCTGGTCT
TAGGAGGGTGCTAGGCTGCAGACTGCCTTGTACTCCCTGGACACCCTCAAATGGGGTTTTCTGTGTTATTTCATAAAATTCTTTGAAGTC

>99893_99893_1_YAP1-STIM1_YAP1_chr11_102080295_ENST00000282441_STIM1_chr11_4045103_ENST00000300737_length(amino acids)=939AA_BP=343
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMN
QRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQFLREDLNYHDPTVKHS
TFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALD
TVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKL
RDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVA
KEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRP
NPAHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRDLTHSDSESSLHMSDRQRVAPKPPQMSRAADEALNAMTSNGS
HRLIEGVHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMELSPSAPPGGSPHLDSSRSHSPSSPDPDTPSPVGDSRALQASRNTRIPH

--------------------------------------------------------------
>99893_99893_2_YAP1-STIM1_YAP1_chr11_102080295_ENST00000282441_STIM1_chr11_4045103_ENST00000527651_length(transcript)=3245nt_BP=1420nt
GCCGCCGCCAGGGAAAAGAAAGGGAGGAAGGAAGGAACAAGAAAAGGAAATAAAGAGAAAGGGGAGGCGGGGAAAGGCAACGAGCTGTCC
GGCCTCCGTCAAGGGAGTTGGAGGGAAAAAGTTCTCAGGCGCCGCAGGTCCGAGTGCCTCGCAGCCCCTCCCGAGGCGCAGCCGCCAGAC
CAGTGGAGCCGGGGCGCAGGGCGGGGGCGGAGGCGCCGGGGCGGGGGATGCGGGGCCGCGGCGCAGCCCCCCGGCCCTGAGAGCGAGGAC
AGCGCCGCCCGGCCCGCAGCCGTCGCCGCTTCTCCACCTCGGCCCGTGGAGCCGGGGCGTCCGGGCGTAGCCCTCGCTCGCCTGGGTCAG
GGGGTGCGCGTCGGGGGAGGCAGAAGCCATGGATCCCGGGCAGCAGCCGCCGCCTCAACCGGCCCCCCAGGGCCAAGGGCAGCCGCCTTC
GCAGCCCCCGCAGGGGCAGGGCCCGCCGTCCGGACCCGGGCAACCGGCACCCGCGGCGACCCAGGCGGCGCCGCAGGCACCCCCCGCCGG
GCATCAGATCGTGCACGTCCGCGGGGACTCGGAGACCGACCTGGAGGCGCTCTTCAACGCCGTCATGAACCCCAAGACGGCCAACGTGCC
CCAGACCGTGCCCATGAGGCTCCGGAAGCTGCCCGACTCCTTCTTCAAGCCGCCGGAGCCCAAATCCCACTCCCGACAGGCCAGTACTGA
TGCAGGCACTGCAGGAGCCCTGACTCCACAGCATGTTCGAGCTCATTCCTCTCCAGCTTCTCTGCAGTTGGGAGCTGTTTCTCCTGGGAC
ACTGACCCCCACTGGAGTAGTCTCTGGCCCAGCAGCTACACCCACAGCTCAGCATCTTCGACAGTCTTCTTTTGAGATACCTGATGATGT
ACCTCTGCCAGCAGGTTGGGAGATGGCAAAGACATCTTCTGGTCAGAGATACTTCTTAAATCACATCGATCAGACAACAACATGGCAGGA
CCCCAGGAAGGCCATGCTGTCCCAGATGAACGTCACAGCCCCCACCAGTCCACCAGTGCAGCAGAATATGATGAACTCGGCTTCAGGTCC
TCTTCCTGATGGATGGGAACAAGCCATGACTCAGGATGGAGAAATTTACTATATAAACCATAAGAACAAGACCACCTCTTGGCTAGACCC
AAGGCTTGACCCTCGTTTTGCCATGAACCAGAGAATCAGTCAGAGTGCTCCAGTGAAACAGCCACCACCCCTGGCTCCCCAGAGCCCACA
GGGAGGCGTCATGGGTGGCAGCAACTCCAACCAGCAGCAACAGATGCGACTGCAGCAACTGCAGATGGAGAAGGAGAGGCTGCGGCTGAA
ACAGCAAGAACTGCTTCGGCAGGCAATGCGGAATATCAATCCCAGCACAGCAAATTCTCCAAAATGTCAGTTCCTGAGGGAAGACCTCAA
TTACCATGACCCAACAGTGAAACACAGCACCTTCCATGGTGAGGATAAGCTCATCAGCGTGGAGGACCTGTGGAAGGCATGGAAGTCATC
AGAAGTATACAATTGGACCGTGGATGAGGTGGTACAGTGGCTGATCACATATGTGGAGCTGCCTCAGTATGAGGAGACCTTCCGGAAGCT
GCAGCTCAGTGGCCATGCCATGCCAAGGCTGGCTGTCACCAACACCACCATGACAGGGACTGTGCTGAAGATGACAGACCGGAGTCATCG
GCAGAAGCTGCAGCTGAAGGCTCTGGATACAGTGCTCTTTGGGCCTCCTCTCTTGACTCGCCATAATCACCTCAAGGACTTCATGCTGGT
GGTGTCTATCGTTATTGGTGTGGGCGGCTGCTGGTTTGCCTATATCCAGAACCGTTACTCCAAGGAGCACATGAAGAAGATGATGAAGGA
CTTGGAGGGGTTACACCGAGCTGAGCAGAGTCTGCATGACCTTCAGGAAAGGCTGCACAAGGCCCAGGAGGAGCACCGCACAGTGGAGGT
GGAGAAGGTCCATCTGGAAAAGAAGCTGCGCGATGAGATCAACCTTGCTAAGCAGGAAGCCCAGCGGCTGAAGGAGCTGCGGGAGGGTAC
TGAGAATGAGCGGAGCCGCCAAAAATATGCTGAGGAGGAGTTGGAGCAGGTTCGGGAGGCCTTGAGGAAAGCAGAGAAGGAGCTAGAATC
TCACAGCTCATGGTATGCTCCAGAGGCCCTTCAGAAGTGGCTGCAGCTGACACATGAGGTGGAGGTGCAATATTACAACATCAAGAAGCA
AAATGCTGAGAAGCAGCTGCTGGTGGCCAAGGAGGGGGCTGAGAAGATAAAAAAGAAGAGAAACACACTCTTTGGCACCTTCCACGTGGC
CCACAGCTCTTCCCTGGATGATGTAGATCATAAAATTCTAACAGCTAAGCAAGCACTGAGCGAGGTGACAGCAGCATTGCGGGAGCGCCT
GCACCGCTGGCAACAGATCGAGATCCTCTGTGGCTTCCAGATTGTCAACAACCCTGGCATCCACTCACTGGTGGCTGCCCTCAACATAGA
CCCCAGCTGGATGGGCAGTACACGCCCCAACCCTGCTCACTTCATCATGACTGACGACGTGGATGACATGGATGAGGAGATTGTGTCTCC
CTTGTCCATGCAGTCCCCTAGCCTGCAGAGCAGTGTTCGGCAGCGCCTGACGGAGCCACAGCATGGCCTGGGATCTCAGAGAGGATCATC
TCTAAAGGCAAACAGGCTCTCTAGTAAGGGATTTGACCCATTCCGATTCGGAGTCCTCCCTCCACATGAGTGACCGCCAGCGTGTGGCCC
CCAAACCTCCTCAGATGAGCCGTGCTGCAGACGAGGCTCTCAATGCCATGACTTCCAATGGCAGCCACCGGCTGATCGAGGGGGTCCACC
CAGGGTCTCTGGTGGAGAAACTGCCTGACAGCCCTGCCCTGGCCAAGAAGGCATTACTGGCGCTGAACCATGGGCTGGACAAGGCCCACA
GCCTGATGGAGCTGAGCCCCTCAGCCCCACCTGGTGGCTCTCCACATTTGGATTCTTCCCGTTCTCACAGCCCCAGCTCCCCAGACCCAG
ACACACCATCTCCAGTTGGGGACAGCCGAGCCCTGCAAGCCAGCCGAAACACACGCATTCCCCACCTGGCTGGCAAGAAGGCTGTGGCTG
AGGAGGATAATGGCTCTATTGGCGAGGAAACAGACTCCAGCCCAGGCCGGAAGAAGTTTCCCCTCAAAATCTTTAAGAAGCCTCTTAAGA

>99893_99893_2_YAP1-STIM1_YAP1_chr11_102080295_ENST00000282441_STIM1_chr11_4045103_ENST00000527651_length(amino acids)=794AA_BP=343
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMN
QRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQFLREDLNYHDPTVKHS
TFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALD
TVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKL
RDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVA
KEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRP

--------------------------------------------------------------
>99893_99893_3_YAP1-STIM1_YAP1_chr11_102080295_ENST00000524575_STIM1_chr11_4045103_ENST00000300737_length(transcript)=4142nt_BP=943nt
CTGCAATGTAGTTAGCCCACTCGGGATGTAACTTGAGTGGAAAGAAGAGTTACCGCCCCCACTCCCATTCCCTCTCCTATTTGCAGGCCT
GTTGTATAGTCTCCTGTCGGAGACCAAAGGGTTTTGGAACTCAGAAAAAATCACTTAACCTGATGACAAAAACCCGGGTTAAGGAGGAGG
AAAGAAGGAAAAACAATTTAGCTGCTTGCCTAAACACTTCAATTTGTCTTAGGCCAGTACTGATGCAGGCACTGCAGGAGCCCTGACTCC
ACAGCATGTTCGAGCTCATTCCTCTCCAGCTTCTCTGCAGTTGGGAGCTGTTTCTCCTGGGACACTGACCCCCACTGGAGTAGTCTCTGG
CCCAGCAGCTACACCCACAGCTCAGCATCTTCGACAGTCTTCTTTTGAGATACCTGATGATGTACCTCTGCCAGCAGGTTGGGAGATGGC
AAAGACATCTTCTGGTCAGAGATACTTCTTAAATCACATCGATCAGACAACAACATGGCAGGACCCCAGGAAGGCCATGCTGTCCCAGAT
GAACGTCACAGCCCCCACCAGTCCACCAGTGCAGCAGAATATGATGAACTCGGCTTCAGGTCCTCTTCCTGATGGATGGGAACAAGCCAT
GACTCAGGATGGAGAAATTTACTATATAAACCATAAGAACAAGACCACCTCTTGGCTAGACCCAAGGCTTGACCCTCGTTTTGCCATGAA
CCAGAGAATCAGTCAGAGTGCTCCAGTGAAACAGCCACCACCCCTGGCTCCCCAGAGCCCACAGGGAGGCGTCATGGGTGGCAGCAACTC
CAACCAGCAGCAACAGATGCGACTGCAGCAACTGCAGATGGAGAAGGAGAGGCTGCGGCTGAAACAGCAAGAACTGCTTCGGCAGGCAAT
GCGGAATATCAATCCCAGCACAGCAAATTCTCCAAAATGTCAGTTCCTGAGGGAAGACCTCAATTACCATGACCCAACAGTGAAACACAG
CACCTTCCATGGTGAGGATAAGCTCATCAGCGTGGAGGACCTGTGGAAGGCATGGAAGTCATCAGAAGTATACAATTGGACCGTGGATGA
GGTGGTACAGTGGCTGATCACATATGTGGAGCTGCCTCAGTATGAGGAGACCTTCCGGAAGCTGCAGCTCAGTGGCCATGCCATGCCAAG
GCTGGCTGTCACCAACACCACCATGACAGGGACTGTGCTGAAGATGACAGACCGGAGTCATCGGCAGAAGCTGCAGCTGAAGGCTCTGGA
TACAGTGCTCTTTGGGCCTCCTCTCTTGACTCGCCATAATCACCTCAAGGACTTCATGCTGGTGGTGTCTATCGTTATTGGTGTGGGCGG
CTGCTGGTTTGCCTATATCCAGAACCGTTACTCCAAGGAGCACATGAAGAAGATGATGAAGGACTTGGAGGGGTTACACCGAGCTGAGCA
GAGTCTGCATGACCTTCAGGAAAGGCTGCACAAGGCCCAGGAGGAGCACCGCACAGTGGAGGTGGAGAAGGTCCATCTGGAAAAGAAGCT
GCGCGATGAGATCAACCTTGCTAAGCAGGAAGCCCAGCGGCTGAAGGAGCTGCGGGAGGGTACTGAGAATGAGCGGAGCCGCCAAAAATA
TGCTGAGGAGGAGTTGGAGCAGGTTCGGGAGGCCTTGAGGAAAGCAGAGAAGGAGCTAGAATCTCACAGCTCATGGTATGCTCCAGAGGC
CCTTCAGAAGTGGCTGCAGCTGACACATGAGGTGGAGGTGCAATATTACAACATCAAGAAGCAAAATGCTGAGAAGCAGCTGCTGGTGGC
CAAGGAGGGGGCTGAGAAGATAAAAAAGAAGAGAAACACACTCTTTGGCACCTTCCACGTGGCCCACAGCTCTTCCCTGGATGATGTAGA
TCATAAAATTCTAACAGCTAAGCAAGCACTGAGCGAGGTGACAGCAGCATTGCGGGAGCGCCTGCACCGCTGGCAACAGATCGAGATCCT
CTGTGGCTTCCAGATTGTCAACAACCCTGGCATCCACTCACTGGTGGCTGCCCTCAACATAGACCCCAGCTGGATGGGCAGTACACGCCC
CAACCCTGCTCACTTCATCATGACTGACGACGTGGATGACATGGATGAGGAGATTGTGTCTCCCTTGTCCATGCAGTCCCCTAGCCTGCA
GAGCAGTGTTCGGCAGCGCCTGACGGAGCCACAGCATGGCCTGGGATCTCAGAGGGATTTGACCCATTCCGATTCGGAGTCCTCCCTCCA
CATGAGTGACCGCCAGCGTGTGGCCCCCAAACCTCCTCAGATGAGCCGTGCTGCAGACGAGGCTCTCAATGCCATGACTTCCAATGGCAG
CCACCGGCTGATCGAGGGGGTCCACCCAGGGTCTCTGGTGGAGAAACTGCCTGACAGCCCTGCCCTGGCCAAGAAGGCATTACTGGCGCT
GAACCATGGGCTGGACAAGGCCCACAGCCTGATGGAGCTGAGCCCCTCAGCCCCACCTGGTGGCTCTCCACATTTGGATTCTTCCCGTTC
TCACAGCCCCAGCTCCCCAGACCCAGACACACCATCTCCAGTTGGGGACAGCCGAGCCCTGCAAGCCAGCCGAAACACACGCATTCCCCA
CCTGGCTGGCAAGAAGGCTGTGGCTGAGGAGGATAATGGCTCTATTGGCGAGGAAACAGACTCCAGCCCAGGCCGGAAGAAGTTTCCCCT
CAAAATCTTTAAGAAGCCTCTTAAGAAGTAGGCAGGATGGGGTGGCAGTAAAGGGACAGCTTGTCCTTCCCTGGGTGTTCTGTCTCTCCT
TCCCTCCCTTCCTTCAAGATAACTGGCCCCAAGAGTGGGGCATGGGAAGGGCTGGTCCAGGGGTCTGGGCACTGTACATACCTGCCCCCT
CATCCTTGGGTCCTTCATTATTATTTATTAACTGACCACCATGGCCTGCCTGCCCTGCCTCCGTCCCAACCATGGGCTGCTGCTGTCACT
CCCTCTCCACTTCAGTGCATGTCTTAGTTGCTGTTCCCTCAGCTCCCAGCTCCACCTCTGGGGTTCAGCTTCTGTCTCTGCTGTCCCAGT
TTTGAGGTTTGGTTTCTTGTTTCTGTCTCTTGCTTTCGGGCTCCTCCCTCCCACCACTCCCCAACTTCCCCTAGCAGTTGCAGGGAAGAT
AGGACGAGTAGCTTCTGACATGTGTGCCTCAGATCTGTTCCACCCCACTCACAGTGGTTCTGTTTGCTCCAGACTGGGGCTAGGGCCTAA
TCTTTGAAGTTTGTTCTTTGGTATTGATGTGGGTCAGAAGGAGCCTCATCCTAATCTCACTCAGGCCTCCAGGGATCCATGGGGGAGTGA
AACCAATTCTCAGAGAACAACCCACCAGAGACTTTTAAAGAGAGGCCAGGCTTGGGAATGGGTTGGGAGAGGCATCTGTTCATTGGAGCA
TGAGTGGATGCCAGAACTGTAGGTTATAAGGCAGTCACTTTTTCTCTCTACTCCCACCCACACCTGCCTCCCTCTTACCCCTGCTCCCCC
ACACTGCAGGAGGATTTGTCTCTAAGAGGTGCTGCCCCAAAGCTCCCCAAGCATCAATACTCCTAGGGCTCAGGACAAGTGGCTCCCCTG
GCCAGGAGAGCCACAGCCATGATACAGGGCTCTTATGGAGCCCTGGAGTTGTTGGGCAAGGATGCTGTCATTTTTTGAACCAAAAGACAA
ACAGGTTAAAAGGAAAAAAAGTAATCTGAATTTCCCAAGTGCCTACGCTGCATATTCCCCTTGTTAGATCCCATTTTCATGTTACTTTGT
AGCCTTGGCCAGAGGCTCAAAAAGGACACAACCAGTTTGGGGAAGGGGTGGCTAAGGAAGATGGTATAGGTGAAGGCGGCTGTGTGACCA
CTTTCCCCCACCCTTCCCACCCTCTAGACAACTCTCTCCCTTACCTGTTTTTGCTATGGCTGTAAAGGTATTTTTCCTCTGCCCCACTCC
CTGCCATACCTTTATCCTGGGATCCTATTTTGGGCCTGGGGTGGGTATACCTGGGGCTGGTCTTAGGAGGGTGCTAGGCTGCAGACTGCC
TTGTACTCCCTGGACACCCTCAAATGGGGTTTTCTGTGTTATTTCATAAAATTCTTTGAAGTCCAATAAAGCATGTAGGAGATTTTAACC

>99893_99893_3_YAP1-STIM1_YAP1_chr11_102080295_ENST00000524575_STIM1_chr11_4045103_ENST00000300737_length(amino acids)=822AA_BP=226
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAML
SQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGG
SNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWT
VDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIG
VGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSR
QKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLD
DVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSP
SLQSSVRQRLTEPQHGLGSQRDLTHSDSESSLHMSDRQRVAPKPPQMSRAADEALNAMTSNGSHRLIEGVHPGSLVEKLPDSPALAKKAL
LALNHGLDKAHSLMELSPSAPPGGSPHLDSSRSHSPSSPDPDTPSPVGDSRALQASRNTRIPHLAGKKAVAEEDNGSIGEETDSSPGRKK

--------------------------------------------------------------
>99893_99893_4_YAP1-STIM1_YAP1_chr11_102080295_ENST00000524575_STIM1_chr11_4045103_ENST00000527651_length(transcript)=2768nt_BP=943nt
CTGCAATGTAGTTAGCCCACTCGGGATGTAACTTGAGTGGAAAGAAGAGTTACCGCCCCCACTCCCATTCCCTCTCCTATTTGCAGGCCT
GTTGTATAGTCTCCTGTCGGAGACCAAAGGGTTTTGGAACTCAGAAAAAATCACTTAACCTGATGACAAAAACCCGGGTTAAGGAGGAGG
AAAGAAGGAAAAACAATTTAGCTGCTTGCCTAAACACTTCAATTTGTCTTAGGCCAGTACTGATGCAGGCACTGCAGGAGCCCTGACTCC
ACAGCATGTTCGAGCTCATTCCTCTCCAGCTTCTCTGCAGTTGGGAGCTGTTTCTCCTGGGACACTGACCCCCACTGGAGTAGTCTCTGG
CCCAGCAGCTACACCCACAGCTCAGCATCTTCGACAGTCTTCTTTTGAGATACCTGATGATGTACCTCTGCCAGCAGGTTGGGAGATGGC
AAAGACATCTTCTGGTCAGAGATACTTCTTAAATCACATCGATCAGACAACAACATGGCAGGACCCCAGGAAGGCCATGCTGTCCCAGAT
GAACGTCACAGCCCCCACCAGTCCACCAGTGCAGCAGAATATGATGAACTCGGCTTCAGGTCCTCTTCCTGATGGATGGGAACAAGCCAT
GACTCAGGATGGAGAAATTTACTATATAAACCATAAGAACAAGACCACCTCTTGGCTAGACCCAAGGCTTGACCCTCGTTTTGCCATGAA
CCAGAGAATCAGTCAGAGTGCTCCAGTGAAACAGCCACCACCCCTGGCTCCCCAGAGCCCACAGGGAGGCGTCATGGGTGGCAGCAACTC
CAACCAGCAGCAACAGATGCGACTGCAGCAACTGCAGATGGAGAAGGAGAGGCTGCGGCTGAAACAGCAAGAACTGCTTCGGCAGGCAAT
GCGGAATATCAATCCCAGCACAGCAAATTCTCCAAAATGTCAGTTCCTGAGGGAAGACCTCAATTACCATGACCCAACAGTGAAACACAG
CACCTTCCATGGTGAGGATAAGCTCATCAGCGTGGAGGACCTGTGGAAGGCATGGAAGTCATCAGAAGTATACAATTGGACCGTGGATGA
GGTGGTACAGTGGCTGATCACATATGTGGAGCTGCCTCAGTATGAGGAGACCTTCCGGAAGCTGCAGCTCAGTGGCCATGCCATGCCAAG
GCTGGCTGTCACCAACACCACCATGACAGGGACTGTGCTGAAGATGACAGACCGGAGTCATCGGCAGAAGCTGCAGCTGAAGGCTCTGGA
TACAGTGCTCTTTGGGCCTCCTCTCTTGACTCGCCATAATCACCTCAAGGACTTCATGCTGGTGGTGTCTATCGTTATTGGTGTGGGCGG
CTGCTGGTTTGCCTATATCCAGAACCGTTACTCCAAGGAGCACATGAAGAAGATGATGAAGGACTTGGAGGGGTTACACCGAGCTGAGCA
GAGTCTGCATGACCTTCAGGAAAGGCTGCACAAGGCCCAGGAGGAGCACCGCACAGTGGAGGTGGAGAAGGTCCATCTGGAAAAGAAGCT
GCGCGATGAGATCAACCTTGCTAAGCAGGAAGCCCAGCGGCTGAAGGAGCTGCGGGAGGGTACTGAGAATGAGCGGAGCCGCCAAAAATA
TGCTGAGGAGGAGTTGGAGCAGGTTCGGGAGGCCTTGAGGAAAGCAGAGAAGGAGCTAGAATCTCACAGCTCATGGTATGCTCCAGAGGC
CCTTCAGAAGTGGCTGCAGCTGACACATGAGGTGGAGGTGCAATATTACAACATCAAGAAGCAAAATGCTGAGAAGCAGCTGCTGGTGGC
CAAGGAGGGGGCTGAGAAGATAAAAAAGAAGAGAAACACACTCTTTGGCACCTTCCACGTGGCCCACAGCTCTTCCCTGGATGATGTAGA
TCATAAAATTCTAACAGCTAAGCAAGCACTGAGCGAGGTGACAGCAGCATTGCGGGAGCGCCTGCACCGCTGGCAACAGATCGAGATCCT
CTGTGGCTTCCAGATTGTCAACAACCCTGGCATCCACTCACTGGTGGCTGCCCTCAACATAGACCCCAGCTGGATGGGCAGTACACGCCC
CAACCCTGCTCACTTCATCATGACTGACGACGTGGATGACATGGATGAGGAGATTGTGTCTCCCTTGTCCATGCAGTCCCCTAGCCTGCA
GAGCAGTGTTCGGCAGCGCCTGACGGAGCCACAGCATGGCCTGGGATCTCAGAGAGGATCATCTCTAAAGGCAAACAGGCTCTCTAGTAA
GGGATTTGACCCATTCCGATTCGGAGTCCTCCCTCCACATGAGTGACCGCCAGCGTGTGGCCCCCAAACCTCCTCAGATGAGCCGTGCTG
CAGACGAGGCTCTCAATGCCATGACTTCCAATGGCAGCCACCGGCTGATCGAGGGGGTCCACCCAGGGTCTCTGGTGGAGAAACTGCCTG
ACAGCCCTGCCCTGGCCAAGAAGGCATTACTGGCGCTGAACCATGGGCTGGACAAGGCCCACAGCCTGATGGAGCTGAGCCCCTCAGCCC
CACCTGGTGGCTCTCCACATTTGGATTCTTCCCGTTCTCACAGCCCCAGCTCCCCAGACCCAGACACACCATCTCCAGTTGGGGACAGCC
GAGCCCTGCAAGCCAGCCGAAACACACGCATTCCCCACCTGGCTGGCAAGAAGGCTGTGGCTGAGGAGGATAATGGCTCTATTGGCGAGG

>99893_99893_4_YAP1-STIM1_YAP1_chr11_102080295_ENST00000524575_STIM1_chr11_4045103_ENST00000527651_length(amino acids)=677AA_BP=226
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAML
SQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGG
SNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWT
VDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIG
VGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSR
QKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLD
DVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for YAP1-STIM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for YAP1-STIM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for YAP1-STIM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource