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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:YBX3-RPS6KA3 (FusionGDB2 ID:99940) |
Fusion Gene Summary for YBX3-RPS6KA3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: YBX3-RPS6KA3 | Fusion gene ID: 99940 | Hgene | Tgene | Gene symbol | YBX3 | RPS6KA3 | Gene ID | 8531 | 6197 |
| Gene name | Y-box binding protein 3 | ribosomal protein S6 kinase A3 | |
| Synonyms | CSDA|CSDA1|DBPA|ZONAB | CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2 | |
| Cytomap | 12p13.2 | Xp22.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Y-box-binding protein 3DNA-binding protein AZO-1-associated nucleic acid-binding proteincold shock domain-containing protein Acold-shock domain containing A1cold-shock domain protein Asingle-strand DNA-binding protein NF-GMB | ribosomal protein S6 kinase alpha-3MAP kinase-activated protein kinase 1bMAPK-activated protein kinase 1bMAPKAP kinase 1bMAPKAPK-1bRSK-2S6K-alpha-3epididymis secretory sperm binding proteininsulin-stimulated protein kinase 1p90-RSK 3ribosomal S6 | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | P16989 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000228251, ENST00000279550, ENST00000546164, | ENST00000540702, ENST00000544447, ENST00000379548, ENST00000479809, ENST00000379565, | |
| Fusion gene scores | * DoF score | 12 X 10 X 6=720 | 10 X 8 X 5=400 |
| # samples | 12 | 10 | |
| ** MAII score | log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/400*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: YBX3 [Title/Abstract] AND RPS6KA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | YBX3(10865810)-RPS6KA3(20252932), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RPS6KA3 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 18402937 |
| Fusion gene breakpoints across YBX3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RPS6KA3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-IN-7808-01A | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
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Fusion Gene ORF analysis for YBX3-RPS6KA3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000228251 | ENST00000540702 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| 5CDS-5UTR | ENST00000228251 | ENST00000544447 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| 5CDS-5UTR | ENST00000279550 | ENST00000540702 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| 5CDS-5UTR | ENST00000279550 | ENST00000544447 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| 5CDS-intron | ENST00000228251 | ENST00000379548 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| 5CDS-intron | ENST00000228251 | ENST00000479809 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| 5CDS-intron | ENST00000279550 | ENST00000379548 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| 5CDS-intron | ENST00000279550 | ENST00000479809 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| In-frame | ENST00000228251 | ENST00000379565 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| In-frame | ENST00000279550 | ENST00000379565 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| intron-3CDS | ENST00000546164 | ENST00000379565 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| intron-5UTR | ENST00000546164 | ENST00000540702 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| intron-5UTR | ENST00000546164 | ENST00000544447 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| intron-intron | ENST00000546164 | ENST00000379548 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| intron-intron | ENST00000546164 | ENST00000479809 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000279550 | YBX3 | chr12 | 10865810 | - | ENST00000379565 | RPS6KA3 | chrX | 20252932 | - | 8410 | 769 | 73 | 2922 | 949 |
| ENST00000228251 | YBX3 | chr12 | 10865810 | - | ENST00000379565 | RPS6KA3 | chrX | 20252932 | - | 8415 | 774 | 78 | 2927 | 949 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000279550 | ENST00000379565 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - | 0.000105341 | 0.9998946 |
| ENST00000228251 | ENST00000379565 | YBX3 | chr12 | 10865810 | - | RPS6KA3 | chrX | 20252932 | - | 0.000105412 | 0.9998946 |
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Fusion Genomic Features for YBX3-RPS6KA3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for YBX3-RPS6KA3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:10865810/chrX:20252932) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| YBX3 | . |
| FUNCTION: Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | YBX3 | chr12:10865810 | chrX:20252932 | ENST00000228251 | - | 5 | 10 | 93_157 | 191 | 378.0 | Domain | Note=CSD |
| Hgene | YBX3 | chr12:10865810 | chrX:20252932 | ENST00000279550 | - | 5 | 9 | 93_157 | 191 | 353.6666666666667 | Domain | Note=CSD |
| Tgene | RPS6KA3 | chr12:10865810 | chrX:20252932 | ENST00000379565 | 0 | 22 | 328_397 | 23 | 741.0 | Domain | AGC-kinase C-terminal | |
| Tgene | RPS6KA3 | chr12:10865810 | chrX:20252932 | ENST00000379565 | 0 | 22 | 422_679 | 23 | 741.0 | Domain | Protein kinase 2 | |
| Tgene | RPS6KA3 | chr12:10865810 | chrX:20252932 | ENST00000379565 | 0 | 22 | 68_327 | 23 | 741.0 | Domain | Protein kinase 1 | |
| Tgene | RPS6KA3 | chr12:10865810 | chrX:20252932 | ENST00000379565 | 0 | 22 | 428_436 | 23 | 741.0 | Nucleotide binding | ATP | |
| Tgene | RPS6KA3 | chr12:10865810 | chrX:20252932 | ENST00000379565 | 0 | 22 | 74_82 | 23 | 741.0 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for YBX3-RPS6KA3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >99940_99940_1_YBX3-RPS6KA3_YBX3_chr12_10865810_ENST00000228251_RPS6KA3_chrX_20252932_ENST00000379565_length(transcript)=8415nt_BP=774nt GCGAGGAGCCCAAGAGAGAGCGCGCAGCACGAAGCTCGAGCCGCCTCCGCCGCGCGACCCCACCTCGGCCGCCGCCGCCTGCGCCGCGAG ATCCGCCCCGGCCTCCCCGAGAGCGAGCCCCGGCCGCCGCGACCACCAGCCGCGCTAACCGCCGACCAACCGCCACCGAGGCGCCTGAGC GAGAGCAGAGGAGGAGGAGGCATGAGTGAGGCGGGCGAGGCCACCACCACCACCACCACCACCCTCCCGCAGGCTCCGACGGAGGCGGCC GCCGCGGCTCCCCAGGACCCCGCGCCCAAGAGCCCGGTGGGCAGCGGTGCGCCCCAGGCCGCGGCCCCGGCGCCCGCCGCCCACGTCGCA GGAAACCCCGGTGGGGACGCGGCCCCCGCAGCCACGGGCACCGCGGCCGCCGCCTCTTTAGCCACCGCCGCCGGCAGCGAAGACGCGGAG AAAAAAGTTCTCGCCACCAAAGTCCTTGGCACTGTCAAATGGTTCAACGTCAGAAATGGATATGGATTTATAAATCGAAATGACACCAAA GAAGATGTATTTGTACATCAGACTGCCATCAAGAAGAATAACCCACGGAAATATCTGCGCAGTGTAGGAGATGGAGAAACTGTAGAGTTT GATGTGGTTGAAGGAGAGAAGGGTGCAGAAGCTGCCAATGTGACTGGCCCGGATGGAGTTCCTGTGGAAGGGAGTCGTTACGCTGCAGAT CGGCGCCGTTACAGACGTGGCTACTATGGAAGGCGCCGTGGCCCTCCCCGGAATAATGGACAGCAAATTATGGATGAACCTATGGGAGAG GAGGAGATTAACCCACAAACTGAAGAAGTCAGTATCAAAGAAATTGCAATCACACATCATGTAAAGGAAGGACATGAAAAGGCAGATCCT TCCCAGTTTGAACTTTTAAAAGTATTAGGGCAGGGATCATTTGGAAAGGTTTTCTTAGTTAAAAAAATCTCAGGCTCTGATGCTAGGCAG CTTTATGCCATGAAGGTATTGAAGAAGGCCACACTGAAAGTTCGAGACCGAGTTCGGACAAAAATGGAACGTGATATCTTGGTAGAGGTT AATCATCCTTTTATTGTCAAGTTGCATTATGCTTTTCAAACTGAAGGGAAGTTGTATCTTATTTTGGATTTTCTCAGGGGAGGAGATTTG TTTACACGCTTATCCAAAGAGGTGATGTTCACAGAAGAAGATGTCAAATTCTACTTGGCTGAACTTGCACTTGCTTTAGACCATCTACAT AGCCTGGGAATAATTTATAGAGACTTAAAACCAGAAAATATACTTCTTGATGAAGAAGGTCACATCAAGTTAACAGATTTCGGCCTAAGT AAAGAGTCTATTGACCATGAAAAGAAGGCATATTCTTTTTGTGGAACTGTGGAGTATATGGCTCCAGAAGTAGTTAATCGTCGAGGTCAT ACTCAGAGTGCTGACTGGTGGTCTTTTGGTGTGTTAATGTTTGAAATGCTTACTGGTACACTCCCTTTCCAAGGAAAAGATCGAAAAGAA ACAATGACTATGATTCTTAAAGCCAAACTTGGAATGCCACAGTTTTTGAGTCCTGAAGCGCAGAGTCTTTTACGAATGCTTTTCAAGCGA AATCCTGCAAACAGATTAGGTGCAGGACCAGATGGAGTTGAAGAAATTAAAAGACATTCATTTTTCTCAACGATAGACTGGAATAAACTG TATAGAAGAGAAATTCATCCGCCATTTAAACCTGCAACGGGCAGGCCTGAAGATACATTCTATTTTGATCCTGAGTTTACTGCAAAAACT CCCAAAGATTCACCTGGCATTCCACCTAGTGCTAATGCACATCAGCTTTTTCGGGGGTTTAGTTTTGTTGCTATTACCTCAGATGATGAA AGCCAAGCTATGCAGACAGTTGGTGTACATTCAATTGTTCAGCAGTTACACAGGAACAGTATTCAGTTTACTGATGGATATGAAGTAAAA GAAGATATTGGAGTTGGCTCCTACTCTGTTTGCAAGAGATGTATACATAAAGCTACAAACATGGAGTTTGCAGTGAAGATTATTGATAAA AGCAAGAGAGACCCAACAGAAGAAATTGAAATTCTTCTTCGTTATGGACAGCATCCAAACATTATCACTCTAAAGGATGTATATGATGAT GGAAAGTATGTGTATGTAGTAACAGAACTTATGAAAGGAGGTGAATTGCTGGATAAAATTCTTAGACAAAAATTTTTCTCTGAACGAGAG GCCAGTGCTGTCCTGTTCACTATAACTAAAACCGTTGAATATCTTCACGCACAAGGGGTGGTTCATAGAGACTTGAAACCTAGCAACATT CTTTATGTGGATGAATCTGGTAATCCGGAATCTATTCGAATTTGTGATTTTGGCTTTGCAAAACAGCTGAGAGCGGAAAATGGTCTTCTC ATGACTCCTTGTTACACTGCAAATTTTGTTGCACCAGAGGTTTTAAAAAGACAAGGCTATGATGCTGCTTGTGATATATGGAGTCTTGGT GTCCTACTCTATACAATGCTTACCGGTTACACTCCATTTGCAAATGGTCCTGATGATACACCAGAGGAAATATTGGCACGAATAGGTAGC GGAAAATTCTCACTCAGTGGTGGTTACTGGAATTCTGTTTCAGACACAGCAAAGGACCTGGTGTCAAAGATGCTTCATGTAGACCCTCAT CAGAGACTGACTGCTGCTCTTGTGCTCAGACATCCTTGGATCGTCCACTGGGACCAACTGCCACAATACCAACTAAACAGACAGGATGCA CCACATCTAGTAAAGGGTGCCATGGCAGCTACATATTCTGCTTTGAACCGTAATCAGTCACCAGTTTTGGAACCAGTAGGCCGCTCTACT CTTGCTCAGCGGAGAGGTATTAAAAAAATCACCTCAACAGCCCTGTGAAGTGACCTCAGTGAGATATTTGGTACCATGGTGTAAGCTGAT AGCACAAGTTCTGGCGACAGGTAGCACGTATCTGAGAGACACCTGCAAGCACACACTGTCCCAGCTGGTACCCATAATGCTGCTGTTCCT GCTGCTGCTCCTGCTTTCCTCTCTTCTCGCTTTAAATGATTGTTAGCAAGTTAGATTTTCCTGGAGCTTCGGAAGAAATGAAAATGGAAA CATGATGAAGATATAGTCACTGAATCAATGAGAAAAATAATGAACATATGAATACCACCTAAAAATACACTGAATAAAGTACACCATATA GCATTATTTTTATAGGAAATATTTCATGTCCCTTAAATATTCTTTGTTAGTTATAGGGATGGACAGTTTATGTTAAGCACTTAGCTTAAA CAATCCGTTTATATTAGCACTGTATCCCTTGTGCCATCCAACATTTTGTATGTTTTTGTAAACAGTTCATATACAGTACATTTCTGTACT GCTTTCTTTAATGTATACATGCCTTGTTTAACTTGGAATCTATTATTATTAATCAATTGACTATTAAATCTGGTTAAATAGTTCACCTGG ATTAACAGTATTGTTGGACAGTCCTAAAAATGGCCAGATTGTGGAACAGCTGTTGAATGTAATACTTCCAAAATGTACATATCTTTCCCC ACGTCTGTTTCACTGGTTCGTTCATTTGTTTGTTTCTTAAAGTCAGGTGCTCTGTCAGACTAACCTAGAGAGCTGTTATGGTAGAGAAAG TTATCATATGTGTGTGGCATGAAATCAAGAATACACCTATGAAGTTAGTCCATATACTTTGCAACTCCTTAGAGTACTTTTTTCCTTAAT TAAGGAAGTAGTCCTTGCACTTCTAATCTTACATAGCATCCATACTTAGAATTTGGCATATCATCTGGGATTTTGCCAATATACGTCAAA GCCCTTTAAGAGTCATGGTAAGGAGATGGGTGAAGGAAAATTTAGCAACAGGTAATTGAAGTCCTATTGGATATTTCATGTTTAAATAGA TATTCTATATTAAACACTAATTTAAATGTAATAAAGGCCAAAGGCCTCTGTATGAAATTGGATTTAAACTTTCTTATTTTAGGGAATAAA ACATTATTGATCAAACAGTATCTGTTCTAACCTAAAATTATAGGTAGGGCAGGCTAAGTGAACAGCATTGAGTATTTTCTGAATCCCTCA TGATAATTTATAGCCACATACTGCTTCCTTTGACTTCAGGAATGATCAGTTTTCATAATGGCCACTGGGCCTGCTTAGATTGCAGTATTC ATTATCTGCATCTAATTTGGTAGTTTCCACAATCGTATTTGATGAAAGAAACTTCAGTCCCCATTATTACCTGTGTCTTTGCCAAGCTGC CTAGCATACATCAGTATGTAATGTAAAAGACATATGAGCAAGAAAAAAGTGATTTAACTTACCTCATCAAGAATGTGCCCCTACAGGCCG GGCGCAGTGGCTCACGCCTGTAATCCCAGCATTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCC AACATGGTGAAACCCCGTCTCTACTAAAAAATACAAAAATTAGCTGGGCATGGTGGCGTGCACCTGTAATCCTAGCTACTCAGGAGGCTG AGGCAGGAGAATCGCTTGAACCTGGGAGGTGGTGGTTGCAGTGAGCCAAGATCACACCATTGCACTCCAGCCTGGGTGACAGAGTGAGAC TCTGTCTCAAGAAGGAAAAAAAAAAAAAAGAATGTACTCATACAGATTTTTGTTAGTCATCATGTAATAAGCCATTTATATCAGAAACCT TTTTTCCTGCCACAGAAGCTTTAAATTTTCCCCTAAGAGTACAAAGCCAAGAGAGTGTGGTTTATCTAAATGTCCTGAAATCCACTTGTC ATTCCTTAATTTCTCCTCTATGCAATTAAAGAGAAAGGGGAAATCTATAACATTTCTTTTGCCCAAGTGACACAAAAATGATTACTGCAT AGAAATCAAATGTAAGTTTAGCTTCTAAATGAAATAATATATAGGAGGGATATCAGAATGTCTAGATAGAGAAAGTATTTTCAAATTCTT GAATATATGGATGCTATTAAAAGCTGCTTTCCATTGCCTGGAAAGAGAGCTTTTTTCCCTCCTCTATTCAGTGTTTCAAACTTTGGTCAT CTCAAATTATTGTCACTTTTAAAATGTTAATGTCATTCTGAGCAGAAATAGATATATTTTCAGATTTTTTTACACTGATGCTACTCCGTA ATTGCTTAGGAGTATTGTCCATCATAGTATTTTAGAACTAGAAGTAAACACATAAATCCTTATAAATTACCCAATCCAACTTTCTCATAT TGCATGTAGAGAACCTGAGACACATATCAAAGTCTAGAATCCTTAACTTCTCCCCATTTTGTTTTTTTCCGCCTCATCACACCATGCTGC CTTTCCCTCATATGATCACCAACCAGTAGCTGAGTTCAAAAACTACATATTTCTTGGGCAGTCCTCTACTGGTATGTGATGCCAACTTTT ATTTCTTTCGAAGATAATTGCCTTCTTTGCCTAGCCAAGCAGCCAATTTTATTGGAGAAAAGCAAGTTATATGTTCACAAAATGGAAGGC TTTCTACCTAAATTTATTTCATCTGTGGTCCTCTTATTCTCTTCCATTGCTTTTGACATACAGTGGAAAAACTTGGCCAACGATGTGCTC TAAATATAGTGCTTGTGTTGGGTTAACTTTTCCATTAATTTCTCAACATCAATTATTCAGGCCCCTACAGTTGTGGTATTGAGGCCCCTA AAGGCTTCTGCCTTTCACCAATTAGTGCTGCCAGTTACTGAGGCTTCTCCCAAAAGGTATCAGTCCAGTCTTAAAGATATTTCATTGTGA AAGAAGAAACTAAACTATCAGGCCTCTTTTACAAAATGAGAGATTGAATTTAAGCTTGTCAAGCACGTACTGGAAGGTATGAATTACACT ACCATGTGTTTTGTATCTTCCCTTTCAAGTGATGATGTTAAATGAAGGTAAGTTTTTCATCCTTTTTTAATTTTTGTTTTTTATAAATCA TTTCAGCTTTTTCTGGTTTATAGAGGTGTCTTATTTCTAATGCAACAGACCCCCAACTTTAACAGATTTGATATGGATGCATTTATTCAC AAGCAACCCCAAAAGTCCAAAAATGTAATAATTTTGACAAGGCCCAAAGTTGAGATGCTATGAAGCTTGTGTGTGTGAAAAGTCAGTTAT GATTGTCTGGAGAGAAGCTGTGGTGTGTATGCTGTAGAGTTTCCACATTTCACATGCAGTGTACTCCAAAAAGCGGGTTTGGGTCAACCA TTTCCCATCTCTTTTTAAGAAGTGACTGCTGTTGGGGCCAGGGGACATCATGGGAGGTGGGGCTGTCCAGTTAGCTGTGCCCTGCACCTT CAGCCCAGGAAAGATTTGAACAGAGCAAAGGCTTCAAGAGAGGGCAGAATGTATTCGGCAGAAAAGGGACTCAGGTAAGCCCAGCCTGGG ATGAGAGCAGAAAAGCATTCAAGATTTGCAGGCCTTGCTATGGATGCGCTTAATCACCATGGAGGCCAGCAATACCCATCTCAGCATGGC TTTGATATTCTCTACTTCCTGGCCTTTAAAAATGACCTATAATTTTTCAGTTTGCTTTACTATATTTTATAAAGAAAATTCTATCTTATG GTTGATTGAGCATTGAGACTTATGAAGGCATTAGGATAGATAGCTCAGGAATGTAAAGGTTCAGAAAAGGTCTGTTTTCTCAGATTAACA AATATGATGGATTCCATGGCTGACCTTGGTGCTTAAACCAGGAGGTTTCAATCTAGTCCTAGAGTTGTGTCCCTCTGAAAGGCCCAATGC CATGTAACTAACTTTAAACTGGATATATACTTTGAGCCTTACTTAATTCACAGATAAGTTGACTTAACTCAGTATTTTTATTTCAATTAA TGAAAACAGTCCTCTTTTCAACCCCAGGTTGCTTACATTTTGCTGGTCTCCCCAAGTGACCATTGGTGGAGACCAATTAATGAAGGAATG AAATTCACTTTATTGGGACTGTGGTATTCAACAGAGCCACACTTAACCACTTTTTCCAATGAAGAATCTCCAGAATGATAATGCCCAAAT ATGGATGGCCAAGAAGAATTTGTATCTACGGTGTGCTTTATGTGTTTTTGACACTGCTGTATTCTGTGTGATCAAGTGATTTGCAGCTGG TTCCAATGTGACTGAGTGTTCTCAAAGATTTCTAGTAACTAAGTCAACTTAATTTTCTTAAGCCTGGTATTACTATCAGCCTCACATTTA CCACTTTGATTCTAGTTTTTTAACTGTTCATAACAGGGCATACCGAGGGTTGGGATGAGAGCCTACTTCCTACCTCTTAAGGCACTTTCC TCATTATTTTGCCATATAATCTTGAACTGCATGATAAGCTGTTTAAATGTCCATGACTTCTCCCAGAGCAACTAGCAAAGTATATGACAT TTTGAATAGAGATTAGTGGAAAGGAAAATGTAGAGATTTAAGTTCAGAGGTACAAACCTCAATAAAACCTCCTTAGAGCACATACCATGA GTAGAGTATATGTAAACGTATATGAGAAGAGAGTCGCTATAATAGTCCTCTCTAAGTAGATTAGTTCATTGTCTAATGGAAGTGAACATC TTTACTCCTGTTATCACCATAGTACTGAATGAACTGTATAATGAGTTTTTCAAACAAGTATTTAAAATAGAACTTTCACGTACAAAGCAA GGGCATAAAGATTTTGGTTTGTGTTTCTGTAAGTGTAGTTTACCATCTAAAGCTTTGGTTTTTAATTTTAAAAAAAGCTTCAAGGTATTG CCATTCCTTAGCATCCTTATTGATTATGGGTGATGAGTTTTTAACTCTTAAAATCATATACGTGTATTAGTTTATCTTAACTGTTGCCCT AAGCAAAAGGGAAGGTATACACCTAAGGGATGTACTTATTTTGCATTTTTGGTCATGGGTGGGAATGGGGTGGGTGCCTACTTAAATAGT TTTTAAAAAAGAAAAAAATCACAAATATTTTTCTACTGTTATATATGATCTTCCTTTATACTAGTTTCTCTCTAGTAAGGCATGCCAGAA GCCCAAGATACCATATCATGAATTCTTACATATTGTACCTTTTGTTGGTGGTTAAATCGCATCAGATGCTTGGCATTGCTGCCATAATTA TAAAATGCTTGTAAAGGATCAAATATCACTAAATACTTTAAATTGTTTTACTTAAGAGTCTAATCTGGGAAGTTTTCAAATCATACTATT AATGTGTAATCTAAGCTCTTCAGATGTATCCATGAATAATCCTGGAACAATATTGCTTGTATTCCTGTCATAGAACAGGTTTTGTAATCT >99940_99940_1_YBX3-RPS6KA3_YBX3_chr12_10865810_ENST00000228251_RPS6KA3_chrX_20252932_ENST00000379565_length(amino acids)=949AA_BP=232 MRREIRPGLPESEPRPPRPPAALTADQPPPRRLSESRGGGGMSEAGEATTTTTTTLPQAPTEAAAAAPQDPAPKSPVGSGAPQAAAPAPA AHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGE TVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRGYYGRRRGPPRNNGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHE KADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLR GGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN RRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTID WNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDG YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFF SEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLN -------------------------------------------------------------- >99940_99940_2_YBX3-RPS6KA3_YBX3_chr12_10865810_ENST00000279550_RPS6KA3_chrX_20252932_ENST00000379565_length(transcript)=8410nt_BP=769nt GAGCCCAAGAGAGAGCGCGCAGCACGAAGCTCGAGCCGCCTCCGCCGCGCGACCCCACCTCGGCCGCCGCCGCCTGCGCCGCGAGATCCG CCCCGGCCTCCCCGAGAGCGAGCCCCGGCCGCCGCGACCACCAGCCGCGCTAACCGCCGACCAACCGCCACCGAGGCGCCTGAGCGAGAG CAGAGGAGGAGGAGGCATGAGTGAGGCGGGCGAGGCCACCACCACCACCACCACCACCCTCCCGCAGGCTCCGACGGAGGCGGCCGCCGC GGCTCCCCAGGACCCCGCGCCCAAGAGCCCGGTGGGCAGCGGTGCGCCCCAGGCCGCGGCCCCGGCGCCCGCCGCCCACGTCGCAGGAAA CCCCGGTGGGGACGCGGCCCCCGCAGCCACGGGCACCGCGGCCGCCGCCTCTTTAGCCACCGCCGCCGGCAGCGAAGACGCGGAGAAAAA AGTTCTCGCCACCAAAGTCCTTGGCACTGTCAAATGGTTCAACGTCAGAAATGGATATGGATTTATAAATCGAAATGACACCAAAGAAGA TGTATTTGTACATCAGACTGCCATCAAGAAGAATAACCCACGGAAATATCTGCGCAGTGTAGGAGATGGAGAAACTGTAGAGTTTGATGT GGTTGAAGGAGAGAAGGGTGCAGAAGCTGCCAATGTGACTGGCCCGGATGGAGTTCCTGTGGAAGGGAGTCGTTACGCTGCAGATCGGCG CCGTTACAGACGTGGCTACTATGGAAGGCGCCGTGGCCCTCCCCGGAATAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGA GATTAACCCACAAACTGAAGAAGTCAGTATCAAAGAAATTGCAATCACACATCATGTAAAGGAAGGACATGAAAAGGCAGATCCTTCCCA GTTTGAACTTTTAAAAGTATTAGGGCAGGGATCATTTGGAAAGGTTTTCTTAGTTAAAAAAATCTCAGGCTCTGATGCTAGGCAGCTTTA TGCCATGAAGGTATTGAAGAAGGCCACACTGAAAGTTCGAGACCGAGTTCGGACAAAAATGGAACGTGATATCTTGGTAGAGGTTAATCA TCCTTTTATTGTCAAGTTGCATTATGCTTTTCAAACTGAAGGGAAGTTGTATCTTATTTTGGATTTTCTCAGGGGAGGAGATTTGTTTAC ACGCTTATCCAAAGAGGTGATGTTCACAGAAGAAGATGTCAAATTCTACTTGGCTGAACTTGCACTTGCTTTAGACCATCTACATAGCCT GGGAATAATTTATAGAGACTTAAAACCAGAAAATATACTTCTTGATGAAGAAGGTCACATCAAGTTAACAGATTTCGGCCTAAGTAAAGA GTCTATTGACCATGAAAAGAAGGCATATTCTTTTTGTGGAACTGTGGAGTATATGGCTCCAGAAGTAGTTAATCGTCGAGGTCATACTCA GAGTGCTGACTGGTGGTCTTTTGGTGTGTTAATGTTTGAAATGCTTACTGGTACACTCCCTTTCCAAGGAAAAGATCGAAAAGAAACAAT GACTATGATTCTTAAAGCCAAACTTGGAATGCCACAGTTTTTGAGTCCTGAAGCGCAGAGTCTTTTACGAATGCTTTTCAAGCGAAATCC TGCAAACAGATTAGGTGCAGGACCAGATGGAGTTGAAGAAATTAAAAGACATTCATTTTTCTCAACGATAGACTGGAATAAACTGTATAG AAGAGAAATTCATCCGCCATTTAAACCTGCAACGGGCAGGCCTGAAGATACATTCTATTTTGATCCTGAGTTTACTGCAAAAACTCCCAA AGATTCACCTGGCATTCCACCTAGTGCTAATGCACATCAGCTTTTTCGGGGGTTTAGTTTTGTTGCTATTACCTCAGATGATGAAAGCCA AGCTATGCAGACAGTTGGTGTACATTCAATTGTTCAGCAGTTACACAGGAACAGTATTCAGTTTACTGATGGATATGAAGTAAAAGAAGA TATTGGAGTTGGCTCCTACTCTGTTTGCAAGAGATGTATACATAAAGCTACAAACATGGAGTTTGCAGTGAAGATTATTGATAAAAGCAA GAGAGACCCAACAGAAGAAATTGAAATTCTTCTTCGTTATGGACAGCATCCAAACATTATCACTCTAAAGGATGTATATGATGATGGAAA GTATGTGTATGTAGTAACAGAACTTATGAAAGGAGGTGAATTGCTGGATAAAATTCTTAGACAAAAATTTTTCTCTGAACGAGAGGCCAG TGCTGTCCTGTTCACTATAACTAAAACCGTTGAATATCTTCACGCACAAGGGGTGGTTCATAGAGACTTGAAACCTAGCAACATTCTTTA TGTGGATGAATCTGGTAATCCGGAATCTATTCGAATTTGTGATTTTGGCTTTGCAAAACAGCTGAGAGCGGAAAATGGTCTTCTCATGAC TCCTTGTTACACTGCAAATTTTGTTGCACCAGAGGTTTTAAAAAGACAAGGCTATGATGCTGCTTGTGATATATGGAGTCTTGGTGTCCT ACTCTATACAATGCTTACCGGTTACACTCCATTTGCAAATGGTCCTGATGATACACCAGAGGAAATATTGGCACGAATAGGTAGCGGAAA ATTCTCACTCAGTGGTGGTTACTGGAATTCTGTTTCAGACACAGCAAAGGACCTGGTGTCAAAGATGCTTCATGTAGACCCTCATCAGAG ACTGACTGCTGCTCTTGTGCTCAGACATCCTTGGATCGTCCACTGGGACCAACTGCCACAATACCAACTAAACAGACAGGATGCACCACA TCTAGTAAAGGGTGCCATGGCAGCTACATATTCTGCTTTGAACCGTAATCAGTCACCAGTTTTGGAACCAGTAGGCCGCTCTACTCTTGC TCAGCGGAGAGGTATTAAAAAAATCACCTCAACAGCCCTGTGAAGTGACCTCAGTGAGATATTTGGTACCATGGTGTAAGCTGATAGCAC AAGTTCTGGCGACAGGTAGCACGTATCTGAGAGACACCTGCAAGCACACACTGTCCCAGCTGGTACCCATAATGCTGCTGTTCCTGCTGC TGCTCCTGCTTTCCTCTCTTCTCGCTTTAAATGATTGTTAGCAAGTTAGATTTTCCTGGAGCTTCGGAAGAAATGAAAATGGAAACATGA TGAAGATATAGTCACTGAATCAATGAGAAAAATAATGAACATATGAATACCACCTAAAAATACACTGAATAAAGTACACCATATAGCATT ATTTTTATAGGAAATATTTCATGTCCCTTAAATATTCTTTGTTAGTTATAGGGATGGACAGTTTATGTTAAGCACTTAGCTTAAACAATC CGTTTATATTAGCACTGTATCCCTTGTGCCATCCAACATTTTGTATGTTTTTGTAAACAGTTCATATACAGTACATTTCTGTACTGCTTT CTTTAATGTATACATGCCTTGTTTAACTTGGAATCTATTATTATTAATCAATTGACTATTAAATCTGGTTAAATAGTTCACCTGGATTAA CAGTATTGTTGGACAGTCCTAAAAATGGCCAGATTGTGGAACAGCTGTTGAATGTAATACTTCCAAAATGTACATATCTTTCCCCACGTC TGTTTCACTGGTTCGTTCATTTGTTTGTTTCTTAAAGTCAGGTGCTCTGTCAGACTAACCTAGAGAGCTGTTATGGTAGAGAAAGTTATC ATATGTGTGTGGCATGAAATCAAGAATACACCTATGAAGTTAGTCCATATACTTTGCAACTCCTTAGAGTACTTTTTTCCTTAATTAAGG AAGTAGTCCTTGCACTTCTAATCTTACATAGCATCCATACTTAGAATTTGGCATATCATCTGGGATTTTGCCAATATACGTCAAAGCCCT TTAAGAGTCATGGTAAGGAGATGGGTGAAGGAAAATTTAGCAACAGGTAATTGAAGTCCTATTGGATATTTCATGTTTAAATAGATATTC TATATTAAACACTAATTTAAATGTAATAAAGGCCAAAGGCCTCTGTATGAAATTGGATTTAAACTTTCTTATTTTAGGGAATAAAACATT ATTGATCAAACAGTATCTGTTCTAACCTAAAATTATAGGTAGGGCAGGCTAAGTGAACAGCATTGAGTATTTTCTGAATCCCTCATGATA ATTTATAGCCACATACTGCTTCCTTTGACTTCAGGAATGATCAGTTTTCATAATGGCCACTGGGCCTGCTTAGATTGCAGTATTCATTAT CTGCATCTAATTTGGTAGTTTCCACAATCGTATTTGATGAAAGAAACTTCAGTCCCCATTATTACCTGTGTCTTTGCCAAGCTGCCTAGC ATACATCAGTATGTAATGTAAAAGACATATGAGCAAGAAAAAAGTGATTTAACTTACCTCATCAAGAATGTGCCCCTACAGGCCGGGCGC AGTGGCTCACGCCTGTAATCCCAGCATTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACAT GGTGAAACCCCGTCTCTACTAAAAAATACAAAAATTAGCTGGGCATGGTGGCGTGCACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCA GGAGAATCGCTTGAACCTGGGAGGTGGTGGTTGCAGTGAGCCAAGATCACACCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGT CTCAAGAAGGAAAAAAAAAAAAAAGAATGTACTCATACAGATTTTTGTTAGTCATCATGTAATAAGCCATTTATATCAGAAACCTTTTTT CCTGCCACAGAAGCTTTAAATTTTCCCCTAAGAGTACAAAGCCAAGAGAGTGTGGTTTATCTAAATGTCCTGAAATCCACTTGTCATTCC TTAATTTCTCCTCTATGCAATTAAAGAGAAAGGGGAAATCTATAACATTTCTTTTGCCCAAGTGACACAAAAATGATTACTGCATAGAAA TCAAATGTAAGTTTAGCTTCTAAATGAAATAATATATAGGAGGGATATCAGAATGTCTAGATAGAGAAAGTATTTTCAAATTCTTGAATA TATGGATGCTATTAAAAGCTGCTTTCCATTGCCTGGAAAGAGAGCTTTTTTCCCTCCTCTATTCAGTGTTTCAAACTTTGGTCATCTCAA ATTATTGTCACTTTTAAAATGTTAATGTCATTCTGAGCAGAAATAGATATATTTTCAGATTTTTTTACACTGATGCTACTCCGTAATTGC TTAGGAGTATTGTCCATCATAGTATTTTAGAACTAGAAGTAAACACATAAATCCTTATAAATTACCCAATCCAACTTTCTCATATTGCAT GTAGAGAACCTGAGACACATATCAAAGTCTAGAATCCTTAACTTCTCCCCATTTTGTTTTTTTCCGCCTCATCACACCATGCTGCCTTTC CCTCATATGATCACCAACCAGTAGCTGAGTTCAAAAACTACATATTTCTTGGGCAGTCCTCTACTGGTATGTGATGCCAACTTTTATTTC TTTCGAAGATAATTGCCTTCTTTGCCTAGCCAAGCAGCCAATTTTATTGGAGAAAAGCAAGTTATATGTTCACAAAATGGAAGGCTTTCT ACCTAAATTTATTTCATCTGTGGTCCTCTTATTCTCTTCCATTGCTTTTGACATACAGTGGAAAAACTTGGCCAACGATGTGCTCTAAAT ATAGTGCTTGTGTTGGGTTAACTTTTCCATTAATTTCTCAACATCAATTATTCAGGCCCCTACAGTTGTGGTATTGAGGCCCCTAAAGGC TTCTGCCTTTCACCAATTAGTGCTGCCAGTTACTGAGGCTTCTCCCAAAAGGTATCAGTCCAGTCTTAAAGATATTTCATTGTGAAAGAA GAAACTAAACTATCAGGCCTCTTTTACAAAATGAGAGATTGAATTTAAGCTTGTCAAGCACGTACTGGAAGGTATGAATTACACTACCAT GTGTTTTGTATCTTCCCTTTCAAGTGATGATGTTAAATGAAGGTAAGTTTTTCATCCTTTTTTAATTTTTGTTTTTTATAAATCATTTCA GCTTTTTCTGGTTTATAGAGGTGTCTTATTTCTAATGCAACAGACCCCCAACTTTAACAGATTTGATATGGATGCATTTATTCACAAGCA ACCCCAAAAGTCCAAAAATGTAATAATTTTGACAAGGCCCAAAGTTGAGATGCTATGAAGCTTGTGTGTGTGAAAAGTCAGTTATGATTG TCTGGAGAGAAGCTGTGGTGTGTATGCTGTAGAGTTTCCACATTTCACATGCAGTGTACTCCAAAAAGCGGGTTTGGGTCAACCATTTCC CATCTCTTTTTAAGAAGTGACTGCTGTTGGGGCCAGGGGACATCATGGGAGGTGGGGCTGTCCAGTTAGCTGTGCCCTGCACCTTCAGCC CAGGAAAGATTTGAACAGAGCAAAGGCTTCAAGAGAGGGCAGAATGTATTCGGCAGAAAAGGGACTCAGGTAAGCCCAGCCTGGGATGAG AGCAGAAAAGCATTCAAGATTTGCAGGCCTTGCTATGGATGCGCTTAATCACCATGGAGGCCAGCAATACCCATCTCAGCATGGCTTTGA TATTCTCTACTTCCTGGCCTTTAAAAATGACCTATAATTTTTCAGTTTGCTTTACTATATTTTATAAAGAAAATTCTATCTTATGGTTGA TTGAGCATTGAGACTTATGAAGGCATTAGGATAGATAGCTCAGGAATGTAAAGGTTCAGAAAAGGTCTGTTTTCTCAGATTAACAAATAT GATGGATTCCATGGCTGACCTTGGTGCTTAAACCAGGAGGTTTCAATCTAGTCCTAGAGTTGTGTCCCTCTGAAAGGCCCAATGCCATGT AACTAACTTTAAACTGGATATATACTTTGAGCCTTACTTAATTCACAGATAAGTTGACTTAACTCAGTATTTTTATTTCAATTAATGAAA ACAGTCCTCTTTTCAACCCCAGGTTGCTTACATTTTGCTGGTCTCCCCAAGTGACCATTGGTGGAGACCAATTAATGAAGGAATGAAATT CACTTTATTGGGACTGTGGTATTCAACAGAGCCACACTTAACCACTTTTTCCAATGAAGAATCTCCAGAATGATAATGCCCAAATATGGA TGGCCAAGAAGAATTTGTATCTACGGTGTGCTTTATGTGTTTTTGACACTGCTGTATTCTGTGTGATCAAGTGATTTGCAGCTGGTTCCA ATGTGACTGAGTGTTCTCAAAGATTTCTAGTAACTAAGTCAACTTAATTTTCTTAAGCCTGGTATTACTATCAGCCTCACATTTACCACT TTGATTCTAGTTTTTTAACTGTTCATAACAGGGCATACCGAGGGTTGGGATGAGAGCCTACTTCCTACCTCTTAAGGCACTTTCCTCATT ATTTTGCCATATAATCTTGAACTGCATGATAAGCTGTTTAAATGTCCATGACTTCTCCCAGAGCAACTAGCAAAGTATATGACATTTTGA ATAGAGATTAGTGGAAAGGAAAATGTAGAGATTTAAGTTCAGAGGTACAAACCTCAATAAAACCTCCTTAGAGCACATACCATGAGTAGA GTATATGTAAACGTATATGAGAAGAGAGTCGCTATAATAGTCCTCTCTAAGTAGATTAGTTCATTGTCTAATGGAAGTGAACATCTTTAC TCCTGTTATCACCATAGTACTGAATGAACTGTATAATGAGTTTTTCAAACAAGTATTTAAAATAGAACTTTCACGTACAAAGCAAGGGCA TAAAGATTTTGGTTTGTGTTTCTGTAAGTGTAGTTTACCATCTAAAGCTTTGGTTTTTAATTTTAAAAAAAGCTTCAAGGTATTGCCATT CCTTAGCATCCTTATTGATTATGGGTGATGAGTTTTTAACTCTTAAAATCATATACGTGTATTAGTTTATCTTAACTGTTGCCCTAAGCA AAAGGGAAGGTATACACCTAAGGGATGTACTTATTTTGCATTTTTGGTCATGGGTGGGAATGGGGTGGGTGCCTACTTAAATAGTTTTTA AAAAAGAAAAAAATCACAAATATTTTTCTACTGTTATATATGATCTTCCTTTATACTAGTTTCTCTCTAGTAAGGCATGCCAGAAGCCCA AGATACCATATCATGAATTCTTACATATTGTACCTTTTGTTGGTGGTTAAATCGCATCAGATGCTTGGCATTGCTGCCATAATTATAAAA TGCTTGTAAAGGATCAAATATCACTAAATACTTTAAATTGTTTTACTTAAGAGTCTAATCTGGGAAGTTTTCAAATCATACTATTAATGT GTAATCTAAGCTCTTCAGATGTATCCATGAATAATCCTGGAACAATATTGCTTGTATTCCTGTCATAGAACAGGTTTTGTAATCTTTAAA >99940_99940_2_YBX3-RPS6KA3_YBX3_chr12_10865810_ENST00000279550_RPS6KA3_chrX_20252932_ENST00000379565_length(amino acids)=949AA_BP=232 MRREIRPGLPESEPRPPRPPAALTADQPPPRRLSESRGGGGMSEAGEATTTTTTTLPQAPTEAAAAAPQDPAPKSPVGSGAPQAAAPAPA AHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGE TVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRGYYGRRRGPPRNNGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHE KADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLR GGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN RRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTID WNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDG YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFF SEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for YBX3-RPS6KA3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for YBX3-RPS6KA3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for YBX3-RPS6KA3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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