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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:YEATS4-PARPBP (FusionGDB2 ID:99980)

Fusion Gene Summary for YEATS4-PARPBP

check button Fusion gene summary
Fusion gene informationFusion gene name: YEATS4-PARPBP
Fusion gene ID: 99980
HgeneTgene
Gene symbol

YEATS4

PARPBP

Gene ID

8089

55010

Gene nameYEATS domain containing 4PARP1 binding protein
Synonyms4930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9AROM|C12orf48|PARI
Cytomap

12q15

12q23.2

Type of geneprotein-codingprotein-coding
DescriptionYEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1PCNA-interacting partner
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000247843, ENST00000548020, 
ENST00000535811, ENST00000358383, 
ENST00000392911, ENST00000537257, 
ENST00000327680, ENST00000541394, 
ENST00000378128, ENST00000543784, 
Fusion gene scores* DoF score19 X 5 X 9=8553 X 3 X 3=27
# samples 225
** MAII scorelog2(22/855*10)=-1.9584208962486
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/27*10)=0.888968687611256
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: YEATS4 [Title/Abstract] AND PARPBP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointYEATS4(69756687)-PARPBP(102589729), # samples:1
YEATS4(69756687)-PARPBP(102589728), # samples:1
Anticipated loss of major functional domain due to fusion event.YEATS4-PARPBP seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
YEATS4-PARPBP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYEATS4

GO:0043967

histone H4 acetylation

14966270

HgeneYEATS4

GO:0043968

histone H2A acetylation

14966270


check buttonFusion gene breakpoints across YEATS4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PARPBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A23V-01AYEATS4chr12

69756687

+PARPBPchr12

102589729

+
ChimerDB4SARCTCGA-DX-A23VYEATS4chr12

69756687

+PARPBPchr12

102589728

+


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Fusion Gene ORF analysis for YEATS4-PARPBP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000247843ENST00000535811YEATS4chr12

69756687

+PARPBPchr12

102589729

+
5CDS-3UTRENST00000247843ENST00000535811YEATS4chr12

69756687

+PARPBPchr12

102589728

+
5CDS-3UTRENST00000548020ENST00000535811YEATS4chr12

69756687

+PARPBPchr12

102589729

+
5CDS-3UTRENST00000548020ENST00000535811YEATS4chr12

69756687

+PARPBPchr12

102589728

+
5CDS-intronENST00000247843ENST00000358383YEATS4chr12

69756687

+PARPBPchr12

102589729

+
5CDS-intronENST00000247843ENST00000358383YEATS4chr12

69756687

+PARPBPchr12

102589728

+
5CDS-intronENST00000247843ENST00000392911YEATS4chr12

69756687

+PARPBPchr12

102589729

+
5CDS-intronENST00000247843ENST00000392911YEATS4chr12

69756687

+PARPBPchr12

102589728

+
5CDS-intronENST00000247843ENST00000537257YEATS4chr12

69756687

+PARPBPchr12

102589729

+
5CDS-intronENST00000247843ENST00000537257YEATS4chr12

69756687

+PARPBPchr12

102589728

+
5CDS-intronENST00000548020ENST00000358383YEATS4chr12

69756687

+PARPBPchr12

102589729

+
5CDS-intronENST00000548020ENST00000358383YEATS4chr12

69756687

+PARPBPchr12

102589728

+
5CDS-intronENST00000548020ENST00000392911YEATS4chr12

69756687

+PARPBPchr12

102589729

+
5CDS-intronENST00000548020ENST00000392911YEATS4chr12

69756687

+PARPBPchr12

102589728

+
5CDS-intronENST00000548020ENST00000537257YEATS4chr12

69756687

+PARPBPchr12

102589729

+
5CDS-intronENST00000548020ENST00000537257YEATS4chr12

69756687

+PARPBPchr12

102589728

+
Frame-shiftENST00000247843ENST00000327680YEATS4chr12

69756687

+PARPBPchr12

102589729

+
Frame-shiftENST00000247843ENST00000327680YEATS4chr12

69756687

+PARPBPchr12

102589728

+
Frame-shiftENST00000247843ENST00000541394YEATS4chr12

69756687

+PARPBPchr12

102589729

+
Frame-shiftENST00000247843ENST00000541394YEATS4chr12

69756687

+PARPBPchr12

102589728

+
Frame-shiftENST00000548020ENST00000327680YEATS4chr12

69756687

+PARPBPchr12

102589729

+
Frame-shiftENST00000548020ENST00000327680YEATS4chr12

69756687

+PARPBPchr12

102589728

+
Frame-shiftENST00000548020ENST00000541394YEATS4chr12

69756687

+PARPBPchr12

102589729

+
Frame-shiftENST00000548020ENST00000541394YEATS4chr12

69756687

+PARPBPchr12

102589728

+
In-frameENST00000247843ENST00000378128YEATS4chr12

69756687

+PARPBPchr12

102589729

+
In-frameENST00000247843ENST00000378128YEATS4chr12

69756687

+PARPBPchr12

102589728

+
In-frameENST00000247843ENST00000543784YEATS4chr12

69756687

+PARPBPchr12

102589729

+
In-frameENST00000247843ENST00000543784YEATS4chr12

69756687

+PARPBPchr12

102589728

+
In-frameENST00000548020ENST00000378128YEATS4chr12

69756687

+PARPBPchr12

102589729

+
In-frameENST00000548020ENST00000378128YEATS4chr12

69756687

+PARPBPchr12

102589728

+
In-frameENST00000548020ENST00000543784YEATS4chr12

69756687

+PARPBPchr12

102589729

+
In-frameENST00000548020ENST00000543784YEATS4chr12

69756687

+PARPBPchr12

102589728

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000247843YEATS4chr1269756687+ENST00000378128PARPBPchr12102589729+2011441566156136
ENST00000247843YEATS4chr1269756687+ENST00000543784PARPBPchr12102589729+859441566156136
ENST00000548020YEATS4chr1269756687+ENST00000378128PARPBPchr12102589729+2004434559149136
ENST00000548020YEATS4chr1269756687+ENST00000543784PARPBPchr12102589729+852434559149136
ENST00000247843YEATS4chr1269756687+ENST00000378128PARPBPchr12102589728+2011441566156136
ENST00000247843YEATS4chr1269756687+ENST00000543784PARPBPchr12102589728+859441566156136
ENST00000548020YEATS4chr1269756687+ENST00000378128PARPBPchr12102589728+2004434559149136
ENST00000548020YEATS4chr1269756687+ENST00000543784PARPBPchr12102589728+852434559149136

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000247843ENST00000378128YEATS4chr1269756687+PARPBPchr12102589729+0.68853270.3114673
ENST00000247843ENST00000543784YEATS4chr1269756687+PARPBPchr12102589729+0.901517450.0984826
ENST00000548020ENST00000378128YEATS4chr1269756687+PARPBPchr12102589729+0.74269280.25730714
ENST00000548020ENST00000543784YEATS4chr1269756687+PARPBPchr12102589729+0.910937670.089062296
ENST00000247843ENST00000378128YEATS4chr1269756687+PARPBPchr12102589728+0.68853270.3114673
ENST00000247843ENST00000543784YEATS4chr1269756687+PARPBPchr12102589728+0.901517450.0984826
ENST00000548020ENST00000378128YEATS4chr1269756687+PARPBPchr12102589728+0.74269280.25730714
ENST00000548020ENST00000543784YEATS4chr1269756687+PARPBPchr12102589728+0.910937670.089062296

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Fusion Genomic Features for YEATS4-PARPBP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
YEATS4chr1269756687+PARPBPchr12102589728+0.0011818940.9988181
YEATS4chr1269756687+PARPBPchr12102589728+0.0011818940.9988181
YEATS4chr1269756687+PARPBPchr12102589728+0.0011818940.9988181
YEATS4chr1269756687+PARPBPchr12102589728+0.0011818940.9988181

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for YEATS4-PARPBP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69756687/chr12:102589729)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneYEATS4chr12:69756687chr12:102589728ENST00000247843+27178_22657228.0Coiled coilOntology_term=ECO:0000255
HgeneYEATS4chr12:69756687chr12:102589729ENST00000247843+27178_22657228.0Coiled coilOntology_term=ECO:0000255
HgeneYEATS4chr12:69756687chr12:102589728ENST00000247843+2715_15857228.0DomainYEATS
HgeneYEATS4chr12:69756687chr12:102589729ENST00000247843+2715_15857228.0DomainYEATS
HgeneYEATS4chr12:69756687chr12:102589728ENST00000247843+2793_9757228.0RegionDiacetylated histone H3 binding
HgeneYEATS4chr12:69756687chr12:102589729ENST00000247843+2793_9757228.0RegionDiacetylated histone H3 binding


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Fusion Gene Sequence for YEATS4-PARPBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99980_99980_1_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000247843_PARPBP_chr12_102589728_ENST00000378128_length(transcript)=2011nt_BP=441nt
CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG
CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG
CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT
ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT
GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGAGGGTGTAA
ATCCATCTGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAA
CCAGTCAGACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTC
AACATAAAAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAAT
GTACTGCCAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTAT
GTATCTATAAACCATTCACCAAAGACATGCTTAATTTTTAAGAGATCAAGGTGTAAATTATGATGATTTATTATTTTGGTCTACAGTGTA
TGTAAGGTTAGTATGTTAAGCATTGTTTAAAAATACTAGTAAGTCATAATTATGCAGAATTTTCACAAAGTTTAATGCACAGAGAAAGCA
TATCATTTCAGTTACTGATACATCTTAACACTACTTTCTTTTAAAACAGACATTTAACATACACAAGTTATAGTAGCAGTATGGGCTTCT
CCTCCCATTGGCAATTAAATGCTTTTATTTTCTTCTGAAAAGATGATGTGGACCAACAGGTATCAGACTTGCCAACAAGGTCGGTAGACT
CTTCCCAGCATACATCTGAGCACTGAAGGAAGAAGAAAGTTTAAATTGTTTAAAGGACTATAATTATCACACAAAATTTATTAAGAAAAA
AAGAATGGATCTAGTATAACTAATTCTGAGTAAACCAAAATGATAATAATTAATTGTTGCTATTTAATCCCACATTTTTGGCAGGTGTAA
TTGAGCCATGGTCTTATTTGATTTTGTTATGATTGCATCCAAATTCACTTTAACTCAGAGTTCTGTTTAATGGTGGTAGGATGTAAGAAT
TGAATTTTGAAAAGACTACTCACTGTCAAAATCTCTCCTTCCTATAGGAAATTTAGCTGAGTTTTCTTCATCCCCAATTTCTCTCTTTTC
TTGTGTTGATTCAGTATTCTGAACTCCATTCTCAGCTGGGAAAGCTACAGATCCTTTTAGTGCAAGATAAGGTTTTATAGCCAGATTCAG
TGGCAGACCATGATTTAAGAAATTATGTTTGGAGCCTGTGTTCTGTAAAGAGAAGGTTGATTTGGTTTTTAGCTATCGTATTCGGAGTGG
AACTATAATACAATTGTATAATATTCTTGTTGATCAATTCAAAGTTACTCTGCACTGTTTTTGACTTTTTAAAAATACCTTAGATGCAAA
TTTATAGGAGAAAAAACACTTTCAGATAAGAGGTGTTTGCTGGGATGGAAGAACTACCTGGCATGTAAGAAATATCGTCAGTCGTCCTAA
TGCATATTGTGACTGTTTGCATATACTTCTGTTTATAAAAGTATCAGTTTTACTTTTCAGAGGATTTGTAAGAATCATTTAAATTTTCAT

>99980_99980_1_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000247843_PARPBP_chr12_102589728_ENST00000378128_length(amino acids)=136AA_BP=1
MSFYFLSDWLIFLILFHFYFCPDEHFQNSFQLLIFQQMDLHPLISIWFHIYCPLMSVPIFFSFLSKIPSNITVNYWFNDSNTLYSPAGVR

--------------------------------------------------------------
>99980_99980_2_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000247843_PARPBP_chr12_102589728_ENST00000543784_length(transcript)=859nt_BP=441nt
CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG
CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG
CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT
ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT
GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGAGGGTGTAA
ATCCATCTGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAA
CCAGTCAGACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTC
AACATAAAAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAAT
GTACTGCCAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTAT

>99980_99980_2_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000247843_PARPBP_chr12_102589728_ENST00000543784_length(amino acids)=136AA_BP=1
MSFYFLSDWLIFLILFHFYFCPDEHFQNSFQLLIFQQMDLHPLISIWFHIYCPLMSVPIFFSFLSKIPSNITVNYWFNDSNTLYSPAGVR

--------------------------------------------------------------
>99980_99980_3_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000247843_PARPBP_chr12_102589729_ENST00000378128_length(transcript)=2011nt_BP=441nt
CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG
CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG
CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT
ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT
GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGAGGGTGTAA
ATCCATCTGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAA
CCAGTCAGACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTC
AACATAAAAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAAT
GTACTGCCAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTAT
GTATCTATAAACCATTCACCAAAGACATGCTTAATTTTTAAGAGATCAAGGTGTAAATTATGATGATTTATTATTTTGGTCTACAGTGTA
TGTAAGGTTAGTATGTTAAGCATTGTTTAAAAATACTAGTAAGTCATAATTATGCAGAATTTTCACAAAGTTTAATGCACAGAGAAAGCA
TATCATTTCAGTTACTGATACATCTTAACACTACTTTCTTTTAAAACAGACATTTAACATACACAAGTTATAGTAGCAGTATGGGCTTCT
CCTCCCATTGGCAATTAAATGCTTTTATTTTCTTCTGAAAAGATGATGTGGACCAACAGGTATCAGACTTGCCAACAAGGTCGGTAGACT
CTTCCCAGCATACATCTGAGCACTGAAGGAAGAAGAAAGTTTAAATTGTTTAAAGGACTATAATTATCACACAAAATTTATTAAGAAAAA
AAGAATGGATCTAGTATAACTAATTCTGAGTAAACCAAAATGATAATAATTAATTGTTGCTATTTAATCCCACATTTTTGGCAGGTGTAA
TTGAGCCATGGTCTTATTTGATTTTGTTATGATTGCATCCAAATTCACTTTAACTCAGAGTTCTGTTTAATGGTGGTAGGATGTAAGAAT
TGAATTTTGAAAAGACTACTCACTGTCAAAATCTCTCCTTCCTATAGGAAATTTAGCTGAGTTTTCTTCATCCCCAATTTCTCTCTTTTC
TTGTGTTGATTCAGTATTCTGAACTCCATTCTCAGCTGGGAAAGCTACAGATCCTTTTAGTGCAAGATAAGGTTTTATAGCCAGATTCAG
TGGCAGACCATGATTTAAGAAATTATGTTTGGAGCCTGTGTTCTGTAAAGAGAAGGTTGATTTGGTTTTTAGCTATCGTATTCGGAGTGG
AACTATAATACAATTGTATAATATTCTTGTTGATCAATTCAAAGTTACTCTGCACTGTTTTTGACTTTTTAAAAATACCTTAGATGCAAA
TTTATAGGAGAAAAAACACTTTCAGATAAGAGGTGTTTGCTGGGATGGAAGAACTACCTGGCATGTAAGAAATATCGTCAGTCGTCCTAA
TGCATATTGTGACTGTTTGCATATACTTCTGTTTATAAAAGTATCAGTTTTACTTTTCAGAGGATTTGTAAGAATCATTTAAATTTTCAT

>99980_99980_3_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000247843_PARPBP_chr12_102589729_ENST00000378128_length(amino acids)=136AA_BP=1
MSFYFLSDWLIFLILFHFYFCPDEHFQNSFQLLIFQQMDLHPLISIWFHIYCPLMSVPIFFSFLSKIPSNITVNYWFNDSNTLYSPAGVR

--------------------------------------------------------------
>99980_99980_4_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000247843_PARPBP_chr12_102589729_ENST00000543784_length(transcript)=859nt_BP=441nt
CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG
CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG
CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT
ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT
GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGAGGGTGTAA
ATCCATCTGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAA
CCAGTCAGACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTC
AACATAAAAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAAT
GTACTGCCAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTAT

>99980_99980_4_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000247843_PARPBP_chr12_102589729_ENST00000543784_length(amino acids)=136AA_BP=1
MSFYFLSDWLIFLILFHFYFCPDEHFQNSFQLLIFQQMDLHPLISIWFHIYCPLMSVPIFFSFLSKIPSNITVNYWFNDSNTLYSPAGVR

--------------------------------------------------------------
>99980_99980_5_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000548020_PARPBP_chr12_102589728_ENST00000378128_length(transcript)=2004nt_BP=434nt
CCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAGCACAGTC
GGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCGCGCGACA
GGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAATATGTTCA
AGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGT
ATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGAGGGTGTAAATCCATC
TGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAACCAGTCA
GACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTCAACATAA
AAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAATGTACTGC
CAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTATGTATCTA
TAAACCATTCACCAAAGACATGCTTAATTTTTAAGAGATCAAGGTGTAAATTATGATGATTTATTATTTTGGTCTACAGTGTATGTAAGG
TTAGTATGTTAAGCATTGTTTAAAAATACTAGTAAGTCATAATTATGCAGAATTTTCACAAAGTTTAATGCACAGAGAAAGCATATCATT
TCAGTTACTGATACATCTTAACACTACTTTCTTTTAAAACAGACATTTAACATACACAAGTTATAGTAGCAGTATGGGCTTCTCCTCCCA
TTGGCAATTAAATGCTTTTATTTTCTTCTGAAAAGATGATGTGGACCAACAGGTATCAGACTTGCCAACAAGGTCGGTAGACTCTTCCCA
GCATACATCTGAGCACTGAAGGAAGAAGAAAGTTTAAATTGTTTAAAGGACTATAATTATCACACAAAATTTATTAAGAAAAAAAGAATG
GATCTAGTATAACTAATTCTGAGTAAACCAAAATGATAATAATTAATTGTTGCTATTTAATCCCACATTTTTGGCAGGTGTAATTGAGCC
ATGGTCTTATTTGATTTTGTTATGATTGCATCCAAATTCACTTTAACTCAGAGTTCTGTTTAATGGTGGTAGGATGTAAGAATTGAATTT
TGAAAAGACTACTCACTGTCAAAATCTCTCCTTCCTATAGGAAATTTAGCTGAGTTTTCTTCATCCCCAATTTCTCTCTTTTCTTGTGTT
GATTCAGTATTCTGAACTCCATTCTCAGCTGGGAAAGCTACAGATCCTTTTAGTGCAAGATAAGGTTTTATAGCCAGATTCAGTGGCAGA
CCATGATTTAAGAAATTATGTTTGGAGCCTGTGTTCTGTAAAGAGAAGGTTGATTTGGTTTTTAGCTATCGTATTCGGAGTGGAACTATA
ATACAATTGTATAATATTCTTGTTGATCAATTCAAAGTTACTCTGCACTGTTTTTGACTTTTTAAAAATACCTTAGATGCAAATTTATAG
GAGAAAAAACACTTTCAGATAAGAGGTGTTTGCTGGGATGGAAGAACTACCTGGCATGTAAGAAATATCGTCAGTCGTCCTAATGCATAT
TGTGACTGTTTGCATATACTTCTGTTTATAAAAGTATCAGTTTTACTTTTCAGAGGATTTGTAAGAATCATTTAAATTTTCATTGAAATA

>99980_99980_5_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000548020_PARPBP_chr12_102589728_ENST00000378128_length(amino acids)=136AA_BP=1
MSFYFLSDWLIFLILFHFYFCPDEHFQNSFQLLIFQQMDLHPLISIWFHIYCPLMSVPIFFSFLSKIPSNITVNYWFNDSNTLYSPAGVR

--------------------------------------------------------------
>99980_99980_6_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000548020_PARPBP_chr12_102589728_ENST00000543784_length(transcript)=852nt_BP=434nt
CCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAGCACAGTC
GGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCGCGCGACA
GGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAATATGTTCA
AGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGT
ATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGAGGGTGTAAATCCATC
TGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAACCAGTCA
GACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTCAACATAA
AAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAATGTACTGC
CAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTATGTATCTA

>99980_99980_6_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000548020_PARPBP_chr12_102589728_ENST00000543784_length(amino acids)=136AA_BP=1
MSFYFLSDWLIFLILFHFYFCPDEHFQNSFQLLIFQQMDLHPLISIWFHIYCPLMSVPIFFSFLSKIPSNITVNYWFNDSNTLYSPAGVR

--------------------------------------------------------------
>99980_99980_7_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000548020_PARPBP_chr12_102589729_ENST00000378128_length(transcript)=2004nt_BP=434nt
CCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAGCACAGTC
GGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCGCGCGACA
GGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAATATGTTCA
AGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGT
ATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGAGGGTGTAAATCCATC
TGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAACCAGTCA
GACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTCAACATAA
AAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAATGTACTGC
CAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTATGTATCTA
TAAACCATTCACCAAAGACATGCTTAATTTTTAAGAGATCAAGGTGTAAATTATGATGATTTATTATTTTGGTCTACAGTGTATGTAAGG
TTAGTATGTTAAGCATTGTTTAAAAATACTAGTAAGTCATAATTATGCAGAATTTTCACAAAGTTTAATGCACAGAGAAAGCATATCATT
TCAGTTACTGATACATCTTAACACTACTTTCTTTTAAAACAGACATTTAACATACACAAGTTATAGTAGCAGTATGGGCTTCTCCTCCCA
TTGGCAATTAAATGCTTTTATTTTCTTCTGAAAAGATGATGTGGACCAACAGGTATCAGACTTGCCAACAAGGTCGGTAGACTCTTCCCA
GCATACATCTGAGCACTGAAGGAAGAAGAAAGTTTAAATTGTTTAAAGGACTATAATTATCACACAAAATTTATTAAGAAAAAAAGAATG
GATCTAGTATAACTAATTCTGAGTAAACCAAAATGATAATAATTAATTGTTGCTATTTAATCCCACATTTTTGGCAGGTGTAATTGAGCC
ATGGTCTTATTTGATTTTGTTATGATTGCATCCAAATTCACTTTAACTCAGAGTTCTGTTTAATGGTGGTAGGATGTAAGAATTGAATTT
TGAAAAGACTACTCACTGTCAAAATCTCTCCTTCCTATAGGAAATTTAGCTGAGTTTTCTTCATCCCCAATTTCTCTCTTTTCTTGTGTT
GATTCAGTATTCTGAACTCCATTCTCAGCTGGGAAAGCTACAGATCCTTTTAGTGCAAGATAAGGTTTTATAGCCAGATTCAGTGGCAGA
CCATGATTTAAGAAATTATGTTTGGAGCCTGTGTTCTGTAAAGAGAAGGTTGATTTGGTTTTTAGCTATCGTATTCGGAGTGGAACTATA
ATACAATTGTATAATATTCTTGTTGATCAATTCAAAGTTACTCTGCACTGTTTTTGACTTTTTAAAAATACCTTAGATGCAAATTTATAG
GAGAAAAAACACTTTCAGATAAGAGGTGTTTGCTGGGATGGAAGAACTACCTGGCATGTAAGAAATATCGTCAGTCGTCCTAATGCATAT
TGTGACTGTTTGCATATACTTCTGTTTATAAAAGTATCAGTTTTACTTTTCAGAGGATTTGTAAGAATCATTTAAATTTTCATTGAAATA

>99980_99980_7_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000548020_PARPBP_chr12_102589729_ENST00000378128_length(amino acids)=136AA_BP=1
MSFYFLSDWLIFLILFHFYFCPDEHFQNSFQLLIFQQMDLHPLISIWFHIYCPLMSVPIFFSFLSKIPSNITVNYWFNDSNTLYSPAGVR

--------------------------------------------------------------
>99980_99980_8_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000548020_PARPBP_chr12_102589729_ENST00000543784_length(transcript)=852nt_BP=434nt
CCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAGCACAGTC
GGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCGCGCGACA
GGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAATATGTTCA
AGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGT
ATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGAGGGTGTAAATCCATC
TGTTGGAAGATCAACAATTGGAACGAGTTTTGGAAATGTTCATCTGGACAGAAGTAAAAATGAAAAAGTATCAAGAAAATCAACCAGTCA
GACAGGAAATAAAAGCTCAAAAAGGAAACAGGTGGATTTGGATGGTGAAAATATTCTCTGTGATAATAGAAATGAACCACCTCAACATAA
AAATGCTAAAATACCTAAGAAATCAAATGATTCACAGAATAGATTGTACGGCAAACTAGCTAAAGTAGCAAAAAGTAATAAATGTACTGC
CAAGGACAAGTTGATTTCTGGCCAGGCAAAGTTAACTCAGTTTTTTAGACTATAAATTTGTGTCTTATATGCTTTAGGTTTATGTATCTA

>99980_99980_8_YEATS4-PARPBP_YEATS4_chr12_69756687_ENST00000548020_PARPBP_chr12_102589729_ENST00000543784_length(amino acids)=136AA_BP=1
MSFYFLSDWLIFLILFHFYFCPDEHFQNSFQLLIFQQMDLHPLISIWFHIYCPLMSVPIFFSFLSKIPSNITVNYWFNDSNTLYSPAGVR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for YEATS4-PARPBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneYEATS4chr12:69756687chr12:102589728ENST00000247843+27163_22757.0228.0MLLT10
HgeneYEATS4chr12:69756687chr12:102589729ENST00000247843+27163_22757.0228.0MLLT10
HgeneYEATS4chr12:69756687chr12:102589728ENST00000247843+27168_22757.0228.0TACC1
HgeneYEATS4chr12:69756687chr12:102589729ENST00000247843+27168_22757.0228.0TACC1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for YEATS4-PARPBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for YEATS4-PARPBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource