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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:YEATS4-SLC25A27 (FusionGDB2 ID:99983)

Fusion Gene Summary for YEATS4-SLC25A27

check button Fusion gene summary
Fusion gene informationFusion gene name: YEATS4-SLC25A27
Fusion gene ID: 99983
HgeneTgene
Gene symbol

YEATS4

SLC25A27

Gene ID

8089

9481

Gene nameYEATS domain containing 4solute carrier family 25 member 27
Synonyms4930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9UCP4
Cytomap

12q15

6p12.3

Type of geneprotein-codingprotein-coding
DescriptionYEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1mitochondrial uncoupling protein 4UCP 4uncoupling protein 4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000247843, ENST00000548020, 
ENST00000604908, ENST00000371347, 
ENST00000411689, ENST00000452689, 
Fusion gene scores* DoF score19 X 5 X 9=8554 X 3 X 3=36
# samples 223
** MAII scorelog2(22/855*10)=-1.9584208962486
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YEATS4 [Title/Abstract] AND SLC25A27 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointYEATS4(69764755)-SLC25A27(46636446), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYEATS4

GO:0043967

histone H4 acetylation

14966270

HgeneYEATS4

GO:0043968

histone H2A acetylation

14966270


check buttonFusion gene breakpoints across YEATS4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC25A27 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A7EI-01AYEATS4chr12

69764755

+SLC25A27chr6

46636446

+


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Fusion Gene ORF analysis for YEATS4-SLC25A27

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000247843ENST00000604908YEATS4chr12

69764755

+SLC25A27chr6

46636446

+
5CDS-3UTRENST00000548020ENST00000604908YEATS4chr12

69764755

+SLC25A27chr6

46636446

+
In-frameENST00000247843ENST00000371347YEATS4chr12

69764755

+SLC25A27chr6

46636446

+
In-frameENST00000247843ENST00000411689YEATS4chr12

69764755

+SLC25A27chr6

46636446

+
In-frameENST00000247843ENST00000452689YEATS4chr12

69764755

+SLC25A27chr6

46636446

+
In-frameENST00000548020ENST00000371347YEATS4chr12

69764755

+SLC25A27chr6

46636446

+
In-frameENST00000548020ENST00000411689YEATS4chr12

69764755

+SLC25A27chr6

46636446

+
In-frameENST00000548020ENST00000452689YEATS4chr12

69764755

+SLC25A27chr6

46636446

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000247843YEATS4chr1269764755+ENST00000371347SLC25A27chr646636446+28767841711136321
ENST00000247843YEATS4chr1269764755+ENST00000411689SLC25A27chr646636446+1236784171902243
ENST00000247843YEATS4chr1269764755+ENST00000452689SLC25A27chr646636446+14597841711136321
ENST00000548020YEATS4chr1269764755+ENST00000371347SLC25A27chr646636446+2707615164967267
ENST00000548020YEATS4chr1269764755+ENST00000411689SLC25A27chr646636446+1067615164733189
ENST00000548020YEATS4chr1269764755+ENST00000452689SLC25A27chr646636446+1290615164967267

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000247843ENST00000371347YEATS4chr1269764755+SLC25A27chr646636446+0.0006208250.99937916
ENST00000247843ENST00000411689YEATS4chr1269764755+SLC25A27chr646636446+0.0038988870.99610114
ENST00000247843ENST00000452689YEATS4chr1269764755+SLC25A27chr646636446+0.0020353820.9979646
ENST00000548020ENST00000371347YEATS4chr1269764755+SLC25A27chr646636446+0.0004091480.9995908
ENST00000548020ENST00000411689YEATS4chr1269764755+SLC25A27chr646636446+0.005236350.9947636
ENST00000548020ENST00000452689YEATS4chr1269764755+SLC25A27chr646636446+0.0015067630.9984932

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Fusion Genomic Features for YEATS4-SLC25A27


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
YEATS4chr1269764755+SLC25A27chr646636445+0.0007102960.99928963
YEATS4chr1269764755+SLC25A27chr646636445+0.0007102960.99928963

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for YEATS4-SLC25A27


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69764755/chr6:46636446)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneYEATS4chr12:69764755chr6:46636446ENST00000247843+6715_158171228.0DomainYEATS
HgeneYEATS4chr12:69764755chr6:46636446ENST00000247843+6793_97171228.0RegionDiacetylated histone H3 binding
TgeneSLC25A27chr12:69764755chr6:46636446ENST0000037134749226_317206324.0RepeatNote=Solcar 3
TgeneSLC25A27chr12:69764755chr6:46636446ENST0000041168947226_317206246.0RepeatNote=Solcar 3
TgeneSLC25A27chr12:69764755chr6:46636446ENST0000037134749229_248206324.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A27chr12:69764755chr6:46636446ENST0000037134749288_311206324.0TransmembraneHelical%3B Name%3D6
TgeneSLC25A27chr12:69764755chr6:46636446ENST0000041168947229_248206246.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A27chr12:69764755chr6:46636446ENST0000041168947288_311206246.0TransmembraneHelical%3B Name%3D6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneYEATS4chr12:69764755chr6:46636446ENST00000247843+67178_226171228.0Coiled coilOntology_term=ECO:0000255
TgeneSLC25A27chr12:69764755chr6:46636446ENST00000371347495_8206324.0Compositional biasNote=Poly-Glu
TgeneSLC25A27chr12:69764755chr6:46636446ENST00000411689475_8206246.0Compositional biasNote=Poly-Glu
TgeneSLC25A27chr12:69764755chr6:46636446ENST0000037134749125_217206324.0RepeatNote=Solcar 2
TgeneSLC25A27chr12:69764755chr6:46636446ENST000003713474921_115206324.0RepeatNote=Solcar 1
TgeneSLC25A27chr12:69764755chr6:46636446ENST0000041168947125_217206246.0RepeatNote=Solcar 2
TgeneSLC25A27chr12:69764755chr6:46636446ENST000004116894721_115206246.0RepeatNote=Solcar 1
TgeneSLC25A27chr12:69764755chr6:46636446ENST0000037134749127_144206324.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A27chr12:69764755chr6:46636446ENST0000037134749195_212206324.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A27chr12:69764755chr6:46636446ENST000003713474923_40206324.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A27chr12:69764755chr6:46636446ENST000003713474988_109206324.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A27chr12:69764755chr6:46636446ENST0000041168947127_144206246.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A27chr12:69764755chr6:46636446ENST0000041168947195_212206246.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A27chr12:69764755chr6:46636446ENST000004116894723_40206246.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A27chr12:69764755chr6:46636446ENST000004116894788_109206246.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for YEATS4-SLC25A27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99983_99983_1_YEATS4-SLC25A27_YEATS4_chr12_69764755_ENST00000247843_SLC25A27_chr6_46636446_ENST00000371347_length(transcript)=2876nt_BP=784nt
CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG
CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG
CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT
ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT
GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGATATGTCA
GCATATGTGAAGAAAATCCAGTTTAAATTACATGAAAGCTATGGCAATCCTTTAAGAGTTGTTACTAAACCTCCATATGAAATTACTGAA
ACAGGATGGGGTGAATTCGAAATAATCATCAAAATATTTTTCATTGACCCTAATGAAAGACCTGTAACCCTGTATCATTTGCTAAAGCTG
TTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATG
ATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATATTTAACCACTTATGATACAGTGAAA
CACTACTTGGTATTGAATACACCACTTGAGGACAATATCATGACTCACGGTTTATCAAGTTTATGTTCTGGACTGGTAGCTTCTATTCTG
GGAACACCAGCCGATGTCATCAAAAGCAGAATAATGAATCAACCACGAGATAAACAAGGAAGGGGACTTTTGTATAAATCATCGACTGAC
TGCTTGATTCAGGCTGTTCAAGGTGAAGGATTCATGAGTCTATATAAAGGCTTTTTACCATCTTGGCTGAGAATGACCCCTTGGTCAATG
GTGTTCTGGCTTACTTATGAAAAAATCAGAGAGATGAGTGGAGTCAGTCCATTTTAAACCCCTAAAGATGCAACCCTTAAAGATACAGTG
TTCAGTATTATTGAAATATGGGCATCTGCAACACATACCCCCTATTATTTCTACCTCTTTAGGAAGACACCTATTCCACAGAGACTGATT
TATAGGGGGCAGCACTTTATTTTTTTCTGGAAACCCAAGTTCTCTTTGACTCCTCTTTTTGTCCAAAAGTGATCTGGTCGGATCTCACAA
GGCCATCCAATGAGACCCCGCACAGCATTTTCTAAAGAAGAATCGAAGCCTGACCACTTTCACCTTGGGCAAGAAGGTTTGGCCTTTGAG
TTGCTATTCTATGCTGAAGAGCCTGCTTAGAGGAGGAGTACCAGGAGGGAGCCAGCATTTCAGATCTGAAGTAGACGATAGGAATGTGGA
AGAACACATACATAGTGCTTAAGAAATACATTTAACCTGTTATGTCAGTATTTATCAATGAAGTTTGATAATTCACTTTTCTGTCATTGT
TAAAGCGTACATACTGTAAATTAAAGGGAGGTGAATGGAAATTAATGAATAAACATTTTGAGTTTCCCTAGTGTTGAAGGAAGGTGTACT
TTTTCTTGTCAGAAAGATAAAAAAAATCAAGTTGAGATGATGTTTGAATTTCAAGAAAAGAGGCTGCTTTCTGTCAGTGCCCTCTCATTA
GATCTGTGTTAATTAGTTAGCACTCCACTGCACATGCTAATGACTTCCTCTGACAGCCACACACCGAATCTTGATGAAAAAAGAGAAGAG
CATTTGCCTTGTTACATAGTCTGTTACAAGCCAGATATGTTGCTAGCTCTCAAGAGTTGTAATATATTAAGAACTACAACTTATTTGATT
AAAACTCAGCTGTATAGATCCTTTTATAAAGCACCTTTTGTTAAACATCAGCCTTTCATTGGTATTTTAAAAGCAAGGCAGATAGATATG
AAGTCAGCCAACTCTGACATGCGTCCTTTCTTATCTCCCTTACCTGACACTAGGGGCTCTAGAGAGGCAGAGAGAGCACTCACAAATCAC
ACTAAAACTGCCAGCGGCCTGACTCTTACTCAGTTTAGCAAAAATTCTTGCCTAAAAAGTGATAAGTAAAAATCTGTTTATGGTATACAG
TTATGTCTCGAATCTTTGAATCAAATCCATGTTCTTATTTTAGAAAGGTAAGAGTTCTTCAAATTCAGCTACATACCACCGGCTCTCCCA
ACCTCAGACGGTGGGCATTTCTGGATGGATGGCTGCGGTTATGGATAAAGGCTGTAACTGTTAACACAGAAAAACATGAAAAGCTCAGGC
CCAAGAAAGGCCTTGGAGCCAGCCAAACAGAATTTGTTCTAATGGACATGGATGATGTTGAACAGAAAAAAGTTTACAAGTGCTTTGTGG
TTGCACTAATGTATACTCACTGCCATTTTAAGAGGGGGAAGTACATTTTAAAATATATTTGAATGTCATGTACTGATATGCAGTAGCTTA
TTGTTTTTCTAGTTGCAGAGAATGTGAAGTTTAATCTCTTAAAATATTTAGATGGTCTACTTTTTCATTGAATTTGTCAATATGTAATTG
CGTTGTAAAATATTATATATATATATATATATATATATATATATATATGCTTAACTTCCCAAGTGTTCTGCATTGAACCACTTAGGGAAA

>99983_99983_1_YEATS4-SLC25A27_YEATS4_chr12_69764755_ENST00000247843_SLC25A27_chr6_46636446_ENST00000371347_length(amino acids)=321AA_BP=205
MGPRDRSAVSEGSGDPASPGLFPWRRRLLPWDNMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNE
DMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDP
TAMMQQLLTTSRQLTLGAYKHETEYLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKS

--------------------------------------------------------------
>99983_99983_2_YEATS4-SLC25A27_YEATS4_chr12_69764755_ENST00000247843_SLC25A27_chr6_46636446_ENST00000411689_length(transcript)=1236nt_BP=784nt
CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG
CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG
CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT
ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT
GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGATATGTCA
GCATATGTGAAGAAAATCCAGTTTAAATTACATGAAAGCTATGGCAATCCTTTAAGAGTTGTTACTAAACCTCCATATGAAATTACTGAA
ACAGGATGGGGTGAATTCGAAATAATCATCAAAATATTTTTCATTGACCCTAATGAAAGACCTGTAACCCTGTATCATTTGCTAAAGCTG
TTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATG
ATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATATTTAACCACTTATGATACAGTGAAA
CACTACTTGGTATTGAATACACCACTTGAGGACAATATCATGACTCACGGTTTATCAAGTGATCTGGTCGGATCTCACAAGGCCATCCAA
TGAGACCCCGCACAGCATTTTCTAAAGAAGAATCGAAGCCTGACCACTTTCACCTTGGGCAAGAAGGTTTGGCCTTTGAGTTGCTATTCT
ATGCTGAAGAGCCTGCTTAGAGGAGGAGTACCAGGAGGGAGCCAGCATTTCAGATCTGAAGTAGACGATAGGAATGTGGAAGAACACATA
CATAGTGCTTAAGAAATACATTTAACCTGTTATGTCAGTATTTATCAATGAAGTTTGATAATTCACTTTTCTGTCATTGTTAAAGCGTAC

>99983_99983_2_YEATS4-SLC25A27_YEATS4_chr12_69764755_ENST00000247843_SLC25A27_chr6_46636446_ENST00000411689_length(amino acids)=243AA_BP=205
MGPRDRSAVSEGSGDPASPGLFPWRRRLLPWDNMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNE
DMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDP

--------------------------------------------------------------
>99983_99983_3_YEATS4-SLC25A27_YEATS4_chr12_69764755_ENST00000247843_SLC25A27_chr6_46636446_ENST00000452689_length(transcript)=1459nt_BP=784nt
CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG
CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG
CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT
ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT
GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGATATGTCA
GCATATGTGAAGAAAATCCAGTTTAAATTACATGAAAGCTATGGCAATCCTTTAAGAGTTGTTACTAAACCTCCATATGAAATTACTGAA
ACAGGATGGGGTGAATTCGAAATAATCATCAAAATATTTTTCATTGACCCTAATGAAAGACCTGTAACCCTGTATCATTTGCTAAAGCTG
TTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATG
ATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATATTTAACCACTTATGATACAGTGAAA
CACTACTTGGTATTGAATACACCACTTGAGGACAATATCATGACTCACGGTTTATCAAGTTTATGTTCTGGACTGGTAGCTTCTATTCTG
GGAACACCAGCCGATGTCATCAAAAGCAGAATAATGAATCAACCACGAGATAAACAAGGAAGGGGACTTTTGTATAAATCATCGACTGAC
TGCTTGATTCAGGCTGTTCAAGGTGAAGGATTCATGAGTCTATATAAAGGCTTTTTACCATCTTGGCTGAGAATGACCCCTTGGTCAATG
GTGTTCTGGCTTACTTATGAAAAAATCAGAGAGATGAGTGGAGTCAGTCCATTTTAAACCCCTAAAGATGCAACCCTTAAAGATACAGTG
TTCAGTATTATTGAAATATGGGCATCTGCAACACATACCCCCTATTATTTCTACCTCTTTAGGAAGACACCTATTCCACAGAGACTGATT
TATAGGGGGCAGCACTTTATTTTTTTCTGGAAACCCAAGTTCTCTTTGACTCCTCTTTTTGTCCAAAAGTGATCTGGTCGGATCTCACAA
GGCCATCCAATGAGACCCCGCACAGCATTTTCTAAAGAAGAATCGAAGCCTGACCACTTTCACCTTGGGCAAGAAGGTTTGGCCTTTGAG

>99983_99983_3_YEATS4-SLC25A27_YEATS4_chr12_69764755_ENST00000247843_SLC25A27_chr6_46636446_ENST00000452689_length(amino acids)=321AA_BP=205
MGPRDRSAVSEGSGDPASPGLFPWRRRLLPWDNMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNE
DMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDP
TAMMQQLLTTSRQLTLGAYKHETEYLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKS

--------------------------------------------------------------
>99983_99983_4_YEATS4-SLC25A27_YEATS4_chr12_69764755_ENST00000548020_SLC25A27_chr6_46636446_ENST00000371347_length(transcript)=2707nt_BP=615nt
CCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAGCACAGTC
GGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCGCGCGACA
GGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAATATGTTCA
AGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGT
ATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGTAACCCTGTATCATT
TGCTAAAGCTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACC
CAACAGCAATGATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATATTTAACCACTTATG
ATACAGTGAAACACTACTTGGTATTGAATACACCACTTGAGGACAATATCATGACTCACGGTTTATCAAGTTTATGTTCTGGACTGGTAG
CTTCTATTCTGGGAACACCAGCCGATGTCATCAAAAGCAGAATAATGAATCAACCACGAGATAAACAAGGAAGGGGACTTTTGTATAAAT
CATCGACTGACTGCTTGATTCAGGCTGTTCAAGGTGAAGGATTCATGAGTCTATATAAAGGCTTTTTACCATCTTGGCTGAGAATGACCC
CTTGGTCAATGGTGTTCTGGCTTACTTATGAAAAAATCAGAGAGATGAGTGGAGTCAGTCCATTTTAAACCCCTAAAGATGCAACCCTTA
AAGATACAGTGTTCAGTATTATTGAAATATGGGCATCTGCAACACATACCCCCTATTATTTCTACCTCTTTAGGAAGACACCTATTCCAC
AGAGACTGATTTATAGGGGGCAGCACTTTATTTTTTTCTGGAAACCCAAGTTCTCTTTGACTCCTCTTTTTGTCCAAAAGTGATCTGGTC
GGATCTCACAAGGCCATCCAATGAGACCCCGCACAGCATTTTCTAAAGAAGAATCGAAGCCTGACCACTTTCACCTTGGGCAAGAAGGTT
TGGCCTTTGAGTTGCTATTCTATGCTGAAGAGCCTGCTTAGAGGAGGAGTACCAGGAGGGAGCCAGCATTTCAGATCTGAAGTAGACGAT
AGGAATGTGGAAGAACACATACATAGTGCTTAAGAAATACATTTAACCTGTTATGTCAGTATTTATCAATGAAGTTTGATAATTCACTTT
TCTGTCATTGTTAAAGCGTACATACTGTAAATTAAAGGGAGGTGAATGGAAATTAATGAATAAACATTTTGAGTTTCCCTAGTGTTGAAG
GAAGGTGTACTTTTTCTTGTCAGAAAGATAAAAAAAATCAAGTTGAGATGATGTTTGAATTTCAAGAAAAGAGGCTGCTTTCTGTCAGTG
CCCTCTCATTAGATCTGTGTTAATTAGTTAGCACTCCACTGCACATGCTAATGACTTCCTCTGACAGCCACACACCGAATCTTGATGAAA
AAAGAGAAGAGCATTTGCCTTGTTACATAGTCTGTTACAAGCCAGATATGTTGCTAGCTCTCAAGAGTTGTAATATATTAAGAACTACAA
CTTATTTGATTAAAACTCAGCTGTATAGATCCTTTTATAAAGCACCTTTTGTTAAACATCAGCCTTTCATTGGTATTTTAAAAGCAAGGC
AGATAGATATGAAGTCAGCCAACTCTGACATGCGTCCTTTCTTATCTCCCTTACCTGACACTAGGGGCTCTAGAGAGGCAGAGAGAGCAC
TCACAAATCACACTAAAACTGCCAGCGGCCTGACTCTTACTCAGTTTAGCAAAAATTCTTGCCTAAAAAGTGATAAGTAAAAATCTGTTT
ATGGTATACAGTTATGTCTCGAATCTTTGAATCAAATCCATGTTCTTATTTTAGAAAGGTAAGAGTTCTTCAAATTCAGCTACATACCAC
CGGCTCTCCCAACCTCAGACGGTGGGCATTTCTGGATGGATGGCTGCGGTTATGGATAAAGGCTGTAACTGTTAACACAGAAAAACATGA
AAAGCTCAGGCCCAAGAAAGGCCTTGGAGCCAGCCAAACAGAATTTGTTCTAATGGACATGGATGATGTTGAACAGAAAAAAGTTTACAA
GTGCTTTGTGGTTGCACTAATGTATACTCACTGCCATTTTAAGAGGGGGAAGTACATTTTAAAATATATTTGAATGTCATGTACTGATAT
GCAGTAGCTTATTGTTTTTCTAGTTGCAGAGAATGTGAAGTTTAATCTCTTAAAATATTTAGATGGTCTACTTTTTCATTGAATTTGTCA
ATATGTAATTGCGTTGTAAAATATTATATATATATATATATATATATATATATATATATGCTTAACTTCCCAAGTGTTCTGCATTGAACC
ACTTAGGGAAAATTTTGTTTGTTTTTATGTTTTGTAATTTTTAAAATTAAGTAAAGACTGGATCAAAATAATTGCATCCAACCTGGACCG

>99983_99983_4_YEATS4-SLC25A27_YEATS4_chr12_69764755_ENST00000548020_SLC25A27_chr6_46636446_ENST00000371347_length(amino acids)=267AA_BP=151
MGPRDRSAVSEGSGDPASPGLFPWRRRLLPWDNMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNE
VTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEYLTTYDTVKHYLVLNTPLEDNIMTHGLSSL

--------------------------------------------------------------
>99983_99983_5_YEATS4-SLC25A27_YEATS4_chr12_69764755_ENST00000548020_SLC25A27_chr6_46636446_ENST00000411689_length(transcript)=1067nt_BP=615nt
CCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAGCACAGTC
GGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCGCGCGACA
GGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAATATGTTCA
AGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGT
ATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGTAACCCTGTATCATT
TGCTAAAGCTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACC
CAACAGCAATGATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATATTTAACCACTTATG
ATACAGTGAAACACTACTTGGTATTGAATACACCACTTGAGGACAATATCATGACTCACGGTTTATCAAGTGATCTGGTCGGATCTCACA
AGGCCATCCAATGAGACCCCGCACAGCATTTTCTAAAGAAGAATCGAAGCCTGACCACTTTCACCTTGGGCAAGAAGGTTTGGCCTTTGA
GTTGCTATTCTATGCTGAAGAGCCTGCTTAGAGGAGGAGTACCAGGAGGGAGCCAGCATTTCAGATCTGAAGTAGACGATAGGAATGTGG
AAGAACACATACATAGTGCTTAAGAAATACATTTAACCTGTTATGTCAGTATTTATCAATGAAGTTTGATAATTCACTTTTCTGTCATTG

>99983_99983_5_YEATS4-SLC25A27_YEATS4_chr12_69764755_ENST00000548020_SLC25A27_chr6_46636446_ENST00000411689_length(amino acids)=189AA_BP=151
MGPRDRSAVSEGSGDPASPGLFPWRRRLLPWDNMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNE
VTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEYLTTYDTVKHYLVLNTPLEDNIMTHGLSSD

--------------------------------------------------------------
>99983_99983_6_YEATS4-SLC25A27_YEATS4_chr12_69764755_ENST00000548020_SLC25A27_chr6_46636446_ENST00000452689_length(transcript)=1290nt_BP=615nt
CCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAGCACAGTC
GGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCGCGCGACA
GGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAATATGTTCA
AGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGT
ATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGTAACCCTGTATCATT
TGCTAAAGCTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACC
CAACAGCAATGATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATATTTAACCACTTATG
ATACAGTGAAACACTACTTGGTATTGAATACACCACTTGAGGACAATATCATGACTCACGGTTTATCAAGTTTATGTTCTGGACTGGTAG
CTTCTATTCTGGGAACACCAGCCGATGTCATCAAAAGCAGAATAATGAATCAACCACGAGATAAACAAGGAAGGGGACTTTTGTATAAAT
CATCGACTGACTGCTTGATTCAGGCTGTTCAAGGTGAAGGATTCATGAGTCTATATAAAGGCTTTTTACCATCTTGGCTGAGAATGACCC
CTTGGTCAATGGTGTTCTGGCTTACTTATGAAAAAATCAGAGAGATGAGTGGAGTCAGTCCATTTTAAACCCCTAAAGATGCAACCCTTA
AAGATACAGTGTTCAGTATTATTGAAATATGGGCATCTGCAACACATACCCCCTATTATTTCTACCTCTTTAGGAAGACACCTATTCCAC
AGAGACTGATTTATAGGGGGCAGCACTTTATTTTTTTCTGGAAACCCAAGTTCTCTTTGACTCCTCTTTTTGTCCAAAAGTGATCTGGTC
GGATCTCACAAGGCCATCCAATGAGACCCCGCACAGCATTTTCTAAAGAAGAATCGAAGCCTGACCACTTTCACCTTGGGCAAGAAGGTT

>99983_99983_6_YEATS4-SLC25A27_YEATS4_chr12_69764755_ENST00000548020_SLC25A27_chr6_46636446_ENST00000452689_length(amino acids)=267AA_BP=151
MGPRDRSAVSEGSGDPASPGLFPWRRRLLPWDNMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNE
VTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEYLTTYDTVKHYLVLNTPLEDNIMTHGLSSL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for YEATS4-SLC25A27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneYEATS4chr12:69764755chr6:46636446ENST00000247843+67163_227171.33333333333334228.0MLLT10
HgeneYEATS4chr12:69764755chr6:46636446ENST00000247843+67168_227171.33333333333334228.0TACC1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for YEATS4-SLC25A27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for YEATS4-SLC25A27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource