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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:YEATS4-USP15 (FusionGDB2 ID:99987) |
Fusion Gene Summary for YEATS4-USP15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: YEATS4-USP15 | Fusion gene ID: 99987 | Hgene | Tgene | Gene symbol | YEATS4 | USP15 | Gene ID | 8089 | 9958 |
| Gene name | YEATS domain containing 4 | ubiquitin specific peptidase 15 | |
| Synonyms | 4930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9 | UNPH-2|UNPH4 | |
| Cytomap | 12q15 | 12q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | YEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1 | ubiquitin carboxyl-terminal hydrolase 15deubiquitinating enzyme 15ubiquitin thioesterase 15ubiquitin thiolesterase 15ubiquitin-specific-processing protease 15 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000247843, ENST00000548020, | ENST00000312635, ENST00000550632, ENST00000280377, ENST00000353364, ENST00000393654, | |
| Fusion gene scores | * DoF score | 19 X 5 X 9=855 | 9 X 7 X 5=315 |
| # samples | 22 | 9 | |
| ** MAII score | log2(22/855*10)=-1.9584208962486 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: YEATS4 [Title/Abstract] AND USP15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | YEATS4(69756687)-USP15(62719653), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | YEATS4 | GO:0043967 | histone H4 acetylation | 14966270 |
| Hgene | YEATS4 | GO:0043968 | histone H2A acetylation | 14966270 |
| Tgene | USP15 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 21947082 |
| Tgene | USP15 | GO:0016579 | protein deubiquitination | 16005295|22344298|27368102 |
| Tgene | USP15 | GO:0030509 | BMP signaling pathway | 21947082 |
| Tgene | USP15 | GO:0035520 | monoubiquitinated protein deubiquitination | 21947082|24399297 |
| Tgene | USP15 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination | 24526689 |
| Tgene | USP15 | GO:1900246 | positive regulation of RIG-I signaling pathway | 24399297 |
| Fusion gene breakpoints across YEATS4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across USP15 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-DX-A23V-01A | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + |
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Fusion Gene ORF analysis for YEATS4-USP15 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000247843 | ENST00000312635 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + |
| 5CDS-intron | ENST00000247843 | ENST00000550632 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + |
| 5CDS-intron | ENST00000548020 | ENST00000312635 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + |
| 5CDS-intron | ENST00000548020 | ENST00000550632 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + |
| In-frame | ENST00000247843 | ENST00000280377 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + |
| In-frame | ENST00000247843 | ENST00000353364 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + |
| In-frame | ENST00000247843 | ENST00000393654 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + |
| In-frame | ENST00000548020 | ENST00000280377 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + |
| In-frame | ENST00000548020 | ENST00000353364 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + |
| In-frame | ENST00000548020 | ENST00000393654 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000247843 | YEATS4 | chr12 | 69756687 | + | ENST00000353364 | USP15 | chr12 | 62719653 | + | 4423 | 441 | 171 | 2678 | 835 |
| ENST00000247843 | YEATS4 | chr12 | 69756687 | + | ENST00000280377 | USP15 | chr12 | 62719653 | + | 4510 | 441 | 171 | 2765 | 864 |
| ENST00000247843 | YEATS4 | chr12 | 69756687 | + | ENST00000393654 | USP15 | chr12 | 62719653 | + | 4422 | 441 | 171 | 2678 | 835 |
| ENST00000548020 | YEATS4 | chr12 | 69756687 | + | ENST00000353364 | USP15 | chr12 | 62719653 | + | 4416 | 434 | 164 | 2671 | 835 |
| ENST00000548020 | YEATS4 | chr12 | 69756687 | + | ENST00000280377 | USP15 | chr12 | 62719653 | + | 4503 | 434 | 164 | 2758 | 864 |
| ENST00000548020 | YEATS4 | chr12 | 69756687 | + | ENST00000393654 | USP15 | chr12 | 62719653 | + | 4415 | 434 | 164 | 2671 | 835 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000247843 | ENST00000353364 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + | 0.000128225 | 0.99987173 |
| ENST00000247843 | ENST00000280377 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + | 9.79E-05 | 0.9999021 |
| ENST00000247843 | ENST00000393654 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + | 0.000128726 | 0.99987125 |
| ENST00000548020 | ENST00000353364 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + | 0.000127583 | 0.99987245 |
| ENST00000548020 | ENST00000280377 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + | 9.75E-05 | 0.9999025 |
| ENST00000548020 | ENST00000393654 | YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719653 | + | 0.000128082 | 0.99987185 |
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Fusion Genomic Features for YEATS4-USP15 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719652 | + | 0.65677816 | 0.34322184 |
| YEATS4 | chr12 | 69756687 | + | USP15 | chr12 | 62719652 | + | 0.65677816 | 0.34322184 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for YEATS4-USP15 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69756687/chr12:62719653) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | USP15 | chr12:69756687 | chr12:62719653 | ENST00000280377 | 4 | 22 | 289_933 | 207 | 982.0 | Domain | USP | |
| Tgene | USP15 | chr12:69756687 | chr12:62719653 | ENST00000312635 | 4 | 7 | 289_933 | 207 | 236.0 | Domain | USP | |
| Tgene | USP15 | chr12:69756687 | chr12:62719653 | ENST00000353364 | 4 | 21 | 289_933 | 207 | 953.0 | Domain | USP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | YEATS4 | chr12:69756687 | chr12:62719653 | ENST00000247843 | + | 2 | 7 | 178_226 | 57 | 228.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | YEATS4 | chr12:69756687 | chr12:62719653 | ENST00000247843 | + | 2 | 7 | 15_158 | 57 | 228.0 | Domain | YEATS |
| Hgene | YEATS4 | chr12:69756687 | chr12:62719653 | ENST00000247843 | + | 2 | 7 | 93_97 | 57 | 228.0 | Region | Diacetylated histone H3 binding |
| Tgene | USP15 | chr12:69756687 | chr12:62719653 | ENST00000280377 | 4 | 22 | 7_118 | 207 | 982.0 | Domain | DUSP | |
| Tgene | USP15 | chr12:69756687 | chr12:62719653 | ENST00000312635 | 4 | 7 | 7_118 | 207 | 236.0 | Domain | DUSP | |
| Tgene | USP15 | chr12:69756687 | chr12:62719653 | ENST00000353364 | 4 | 21 | 7_118 | 207 | 953.0 | Domain | DUSP |
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Fusion Gene Sequence for YEATS4-USP15 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >99987_99987_1_YEATS4-USP15_YEATS4_chr12_69756687_ENST00000247843_USP15_chr12_62719653_ENST00000280377_length(transcript)=4510nt_BP=441nt CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGTATTAGTG ATAGAACAGAAAAATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAAGTCCCCAGGTGCATCCAATTTTTCAACTTTACCAAAG ATCTCTCCTTCATCTCTATCAAATAATTATAACAACATGAACAACAGAAATGTGAAAAACTCAAATTACTGTCTTCCATCATATACCGCT TATAAGAACTATGATTATTCGGAACCTGGAAGAAACAATGAACAGCCAGGCCTCTGTGGCCTAAGTAACTTGGGAAATACGTGTTTCATG AACTCAGCTATTCAGTGTTTGAGCAACACACCTCCACTTACTGAGTATTTCCTCAATGATAAGTATCAAGAAGAACTGAATTTTGACAAT CCCTTAGGAATGAGAGGTGAAATAGCTAAATCTTATGCCGAACTGATCAAGCAAATGTGGTCTGGAAAGTTTAGCTACGTCACCCCAAGA GCCTTTAAGACACAGGTAGGACGTTTTGCACCTCAGTTCTCTGGATATCAGCAGCAAGACTGTCAAGAACTGTTAGCTTTCCTATTAGAT GGATTACATGAGGATTTGAATAGAATTAGGAAAAAACCATATATACAATTAAAAGATGCAGATGGAAGGCCAGATAAGGTGGTTGCCGAA GAAGCCTGGGAAAACCATTTAAAACGAAATGATTCTATCATAGTAGATATATTTCATGGCCTTTTCAAATCAACTTTAGTTTGTCCTGAG TGTGCTAAGATTTCAGTAACATTTGATCCTTTTTGTTACTTGACACTTCCATTGCCCATGAAAAAAGAACGCACCTTGGAAGTTTACTTA GTTAGAATGGATCCACTTACCAAACCTATGCAGTACAAAGTGGTTGTCCCCAAAATTGGAAACATATTAGATCTTTGTACAGCATTGTCT GCTTTGTCAGGAATACCTGCAGATAAGATGATAGTTACTGATATATACAATCATAGATTTCACAGAATATTCGCTATGGATGAAAACCTT AGTAGTATTATGGAACGGGATGATATTTATGTGTTTGAAATTAACATCAATAGGACAGAAGATACAGAGCACGTGATTATTCCTGTTTGC CTAAGAGAAAAATTCAGACACTCGAGTTATACCCACCATACTGGTTCTTCACTTTTTGGTCAGCCCTTTCTTATGGCTGTACCACGAAAC AATACTGAAGACAAACTTTATAATCTCCTGCTCTTGAGAATGTGCCGATATGTCAAAATATCTACTGAAACTGAAGAAACTGAAGGATCC CTACACTGCTGTAAGGACCAAAATATTAATGGGAATGGCCCAAATGGCATACATGAAGAAGGCTCACCAAGTGAAATGGAAACAGATGAG CCAGATGATGAATCCAGCCAGGATCAAGAACTTCCCTCAGAGAATGAAAACAGTCAGTCTGAAGATTCAGTTGGAGGAGATAATGATTCT GAAAATGGATTATGTACTGAGGATACTTGCAAAGGTCAACTCACGGGACACAAAAAACGATTGTTTACATTCCAGTTCAACAACTTAGGC AATACTGATATCAACTACATCAAAGATGATACCAGGCATATAAGATTTGATGATAGGCAGCTTAGGCTAGATGAAAGATCTTTTCTTGCT TTGGATTGGGATCCTGATTTGAAAAAAAGATATTTTGATGAAAATGCTGCTGAGGACTTTGAAAAACATGAAAGTGTGGAGTATAAACCT CCTAAAAAACCCTTTGTGAAATTAAAAGATTGCATTGAACTTTTTACAACAAAAGAAAAGCTAGGTGCTGAAGATCCCTGGTATTGTCCG AATTGTAAAGAACATCAGCAAGCCACAAAGAAATTGGATTTATGGTCCCTGCCTCCAGTACTTGTAGTACATCTCAAGCGATTTTCTTAC AGTCGATACATGAGAGACAAGTTGGATACCTTAGTTGATTTTCCTATCAATGACTTGGATATGTCGGAATTCTTAATTAATCCAAATGCA GGTCCTTGCCGCTATAATCTGATTGCTGTTTCCAACCACTATGGAGGGATGGGAGGAGGACACTATACTGCTTTTGCAAAAAATAAAGAT GATGGAAAATGGTACTATTTTGATGACAGTAGTGTCTCCACTGCATCTGAAGACCAAATTGTGTCCAAAGCAGCATATGTACTCTTCTAC CAGAGACAAGACACTTTCAGTGGAACTGGCTTTTTTCCTCTTGACCGAGAAACTAAAGGTGCTTCAGCTGCCACTGGCATCCCATTAGAA AGTGATGAAGATAGCAATGATAATGACAATGATATAGAAAATGAAAACTGTATGCACACTAACTAATGAAAGTCCTAGAAGCCATAAAAG AGACACTTTCCTGCTGGTGGTATCTATGGAAATGATGAAGTTACCCACCACATTAAAACAAAAGTCTGAGATGGGGAGTTTCAGATAACC GAATGTAAATCCTTTATCAGATTTTAACTTGTGCAGTACTTGAAGTGAAACACAATGAAAACTTTAACAGAAATTGTCTCTTAATACATT TACAGTCTTGTATTTACAAGCTAAATATATATAGGAAATCACAAATAAATCCCTTTTAAGTTTGCTGCTGTTTTGATTAATTATGTTTCC TTTAATTTTTTGGATGTGAGTTGATGACAAATGTTAAATTTGTGGATGTTGGTCATTTATTTTGCTCTAATAATACTGCAAGAAAACTAT GGCTGAACTTAGTTTTTGGATAATCTAGTTCATGTGCATTAGGCTGCCGTATATACTACTATGATATTTAGCTGCAGTATCAATGTGGCA TAAATACTGCGGCAGCATTCTTCGAAAACCGCATTTTCAAATTTATCCCCGTAATCAATGTGGGCCTATTAAAAAACCAAATCATGATAC AAGAAACAACCTTGGAAAAGTTATTTCCCTTTGTAATACCTTTAAAAATCCAGAGTATTATATTCATTTTACTGCCACTGTGGAAACAGG TTCTAGATTTCATACTCCATCTAAAGTCATTTTTCAGTTACATGTAAGTATTATTTACTGCTATTGGGATCTATTCTTCAGATATTCAAA AACATTTTTTGCTTTAAAATGCATATCTTTAATTGGGTGTTGGTCCAAAATTAAAATTTTTGCTGTCTGTTTTTCTCTACCCCATTTTGT GGTAATTTGGCAACTTGAGCTCTCCCAATTATTGTAATATAAGGACAGACATAATAGTATTCTGTACCCATAGTAATAATTGCATCAAGC TTAGATGAGAAATTTTTTTCATATACTGGCCTTTAAATCATTAATGGACAATTGGCTATAAAGGTAGGTCTGTTAACTTTCTTTGTGTGT TCCTGATGGAATTCACCATAGCCTTACAGCTTTTCTCAGAAGGTAACTTGTTATAAGAGAAATGGCATTTGCATGTTCCAGAGTCAGAAC CTGTACAGTATATAAAGCATAAACACCTTGAATTTGATTTTAGTTCACCACATTCAAGGATCCAGGATGCCAAAAATATGTGTGAACATT TGAAACATTTTTATTTGCTGCTTTTTCCCTTTGATATAGTTGAAAGAATGTATTGTAAATTGGCATACAATACTGCCTTTAATAGAAAAC CTAAATGCTGGGGCACATTTCACATATCGACTACCTGAGAAATTGCTTTGTGTCCCACTGTTATTAAAGCAAAAAGTATAATGTTCTTCA CTTGAACTAATCAAATACAATAGATTATAAATTGTGTATTGTAAATAAAAGTTCACTCTGTGAGTGCACATTTTGGTAAATTATTTATTT ATGTTAGCATTTAAAAGTTTAAAAAAAATGCATTTGACCAGGATAAATGAGGTATGTTGATCATGGCTTTGCTTTATATCTTGATATTAA AGCTGGTTTATCATCCTGGTATTTTAAAAGCTGCTTTGGGGTTTTTTTTTTCTTTTTTTTTTTTTTAATGTAAACTAACCTCCTGCATGA CAGAGGTTAAAATTTTGTCTGCACTTGAGTTCACTTGAGTTTACATTTGAAATGTGCATGTTTATTTATATAGATTTCAATAAAGCTATT >99987_99987_1_YEATS4-USP15_YEATS4_chr12_69756687_ENST00000247843_USP15_chr12_62719653_ENST00000280377_length(amino acids)=864AA_BP=90 MGPRDRSAVSEGSGDPASPGLFPWRRRLLPWDNMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNE VLVIEQKNEDGTWPRGPSTPKSPGASNFSTLPKISPSSLSNNYNNMNNRNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNT CFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAF LLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLE VYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVII PVCLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPNGIHEEGSPSEME TDEPDDESSQDQELPSENENSQSEDSVGGDNDSENGLCTEDTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERS FLALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKR FSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYV -------------------------------------------------------------- >99987_99987_2_YEATS4-USP15_YEATS4_chr12_69756687_ENST00000247843_USP15_chr12_62719653_ENST00000353364_length(transcript)=4423nt_BP=441nt CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGTATTAGTG ATAGAACAGAAAAATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAATGTGAAAAACTCAAATTACTGTCTTCCATCATATACC GCTTATAAGAACTATGATTATTCGGAACCTGGAAGAAACAATGAACAGCCAGGCCTCTGTGGCCTAAGTAACTTGGGAAATACGTGTTTC ATGAACTCAGCTATTCAGTGTTTGAGCAACACACCTCCACTTACTGAGTATTTCCTCAATGATAAGTATCAAGAAGAACTGAATTTTGAC AATCCCTTAGGAATGAGAGGTGAAATAGCTAAATCTTATGCCGAACTGATCAAGCAAATGTGGTCTGGAAAGTTTAGCTACGTCACCCCA AGAGCCTTTAAGACACAGGTAGGACGTTTTGCACCTCAGTTCTCTGGATATCAGCAGCAAGACTGTCAAGAACTGTTAGCTTTCCTATTA GATGGATTACATGAGGATTTGAATAGAATTAGGAAAAAACCATATATACAATTAAAAGATGCAGATGGAAGGCCAGATAAGGTGGTTGCC GAAGAAGCCTGGGAAAACCATTTAAAACGAAATGATTCTATCATAGTAGATATATTTCATGGCCTTTTCAAATCAACTTTAGTTTGTCCT GAGTGTGCTAAGATTTCAGTAACATTTGATCCTTTTTGTTACTTGACACTTCCATTGCCCATGAAAAAAGAACGCACCTTGGAAGTTTAC TTAGTTAGAATGGATCCACTTACCAAACCTATGCAGTACAAAGTGGTTGTCCCCAAAATTGGAAACATATTAGATCTTTGTACAGCATTG TCTGCTTTGTCAGGAATACCTGCAGATAAGATGATAGTTACTGATATATACAATCATAGATTTCACAGAATATTCGCTATGGATGAAAAC CTTAGTAGTATTATGGAACGGGATGATATTTATGTGTTTGAAATTAACATCAATAGGACAGAAGATACAGAGCACGTGATTATTCCTGTT TGCCTAAGAGAAAAATTCAGACACTCGAGTTATACCCACCATACTGGTTCTTCACTTTTTGGTCAGCCCTTTCTTATGGCTGTACCACGA AACAATACTGAAGACAAACTTTATAATCTCCTGCTCTTGAGAATGTGCCGATATGTCAAAATATCTACTGAAACTGAAGAAACTGAAGGA TCCCTACACTGCTGTAAGGACCAAAATATTAATGGGAATGGCCCAAATGGCATACATGAAGAAGGCTCACCAAGTGAAATGGAAACAGAT GAGCCAGATGATGAATCCAGCCAGGATCAAGAACTTCCCTCAGAGAATGAAAACAGTCAGTCTGAAGATTCAGTTGGAGGAGATAATGAT TCTGAAAATGGATTATGTACTGAGGATACTTGCAAAGGTCAACTCACGGGACACAAAAAACGATTGTTTACATTCCAGTTCAACAACTTA GGCAATACTGATATCAACTACATCAAAGATGATACCAGGCATATAAGATTTGATGATAGGCAGCTTAGGCTAGATGAAAGATCTTTTCTT GCTTTGGATTGGGATCCTGATTTGAAAAAAAGATATTTTGATGAAAATGCTGCTGAGGACTTTGAAAAACATGAAAGTGTGGAGTATAAA CCTCCTAAAAAACCCTTTGTGAAATTAAAAGATTGCATTGAACTTTTTACAACAAAAGAAAAGCTAGGTGCTGAAGATCCCTGGTATTGT CCGAATTGTAAAGAACATCAGCAAGCCACAAAGAAATTGGATTTATGGTCCCTGCCTCCAGTACTTGTAGTACATCTCAAGCGATTTTCT TACAGTCGATACATGAGAGACAAGTTGGATACCTTAGTTGATTTTCCTATCAATGACTTGGATATGTCGGAATTCTTAATTAATCCAAAT GCAGGTCCTTGCCGCTATAATCTGATTGCTGTTTCCAACCACTATGGAGGGATGGGAGGAGGACACTATACTGCTTTTGCAAAAAATAAA GATGATGGAAAATGGTACTATTTTGATGACAGTAGTGTCTCCACTGCATCTGAAGACCAAATTGTGTCCAAAGCAGCATATGTACTCTTC TACCAGAGACAAGACACTTTCAGTGGAACTGGCTTTTTTCCTCTTGACCGAGAAACTAAAGGTGCTTCAGCTGCCACTGGCATCCCATTA GAAAGTGATGAAGATAGCAATGATAATGACAATGATATAGAAAATGAAAACTGTATGCACACTAACTAATGAAAGTCCTAGAAGCCATAA AAGAGACACTTTCCTGCTGGTGGTATCTATGGAAATGATGAAGTTACCCACCACATTAAAACAAAAGTCTGAGATGGGGAGTTTCAGATA ACCGAATGTAAATCCTTTATCAGATTTTAACTTGTGCAGTACTTGAAGTGAAACACAATGAAAACTTTAACAGAAATTGTCTCTTAATAC ATTTACAGTCTTGTATTTACAAGCTAAATATATATAGGAAATCACAAATAAATCCCTTTTAAGTTTGCTGCTGTTTTGATTAATTATGTT TCCTTTAATTTTTTGGATGTGAGTTGATGACAAATGTTAAATTTGTGGATGTTGGTCATTTATTTTGCTCTAATAATACTGCAAGAAAAC TATGGCTGAACTTAGTTTTTGGATAATCTAGTTCATGTGCATTAGGCTGCCGTATATACTACTATGATATTTAGCTGCAGTATCAATGTG GCATAAATACTGCGGCAGCATTCTTCGAAAACCGCATTTTCAAATTTATCCCCGTAATCAATGTGGGCCTATTAAAAAACCAAATCATGA TACAAGAAACAACCTTGGAAAAGTTATTTCCCTTTGTAATACCTTTAAAAATCCAGAGTATTATATTCATTTTACTGCCACTGTGGAAAC AGGTTCTAGATTTCATACTCCATCTAAAGTCATTTTTCAGTTACATGTAAGTATTATTTACTGCTATTGGGATCTATTCTTCAGATATTC AAAAACATTTTTTGCTTTAAAATGCATATCTTTAATTGGGTGTTGGTCCAAAATTAAAATTTTTGCTGTCTGTTTTTCTCTACCCCATTT TGTGGTAATTTGGCAACTTGAGCTCTCCCAATTATTGTAATATAAGGACAGACATAATAGTATTCTGTACCCATAGTAATAATTGCATCA AGCTTAGATGAGAAATTTTTTTCATATACTGGCCTTTAAATCATTAATGGACAATTGGCTATAAAGGTAGGTCTGTTAACTTTCTTTGTG TGTTCCTGATGGAATTCACCATAGCCTTACAGCTTTTCTCAGAAGGTAACTTGTTATAAGAGAAATGGCATTTGCATGTTCCAGAGTCAG AACCTGTACAGTATATAAAGCATAAACACCTTGAATTTGATTTTAGTTCACCACATTCAAGGATCCAGGATGCCAAAAATATGTGTGAAC ATTTGAAACATTTTTATTTGCTGCTTTTTCCCTTTGATATAGTTGAAAGAATGTATTGTAAATTGGCATACAATACTGCCTTTAATAGAA AACCTAAATGCTGGGGCACATTTCACATATCGACTACCTGAGAAATTGCTTTGTGTCCCACTGTTATTAAAGCAAAAAGTATAATGTTCT TCACTTGAACTAATCAAATACAATAGATTATAAATTGTGTATTGTAAATAAAAGTTCACTCTGTGAGTGCACATTTTGGTAAATTATTTA TTTATGTTAGCATTTAAAAGTTTAAAAAAAATGCATTTGACCAGGATAAATGAGGTATGTTGATCATGGCTTTGCTTTATATCTTGATAT TAAAGCTGGTTTATCATCCTGGTATTTTAAAAGCTGCTTTGGGGTTTTTTTTTTCTTTTTTTTTTTTTTAATGTAAACTAACCTCCTGCA TGACAGAGGTTAAAATTTTGTCTGCACTTGAGTTCACTTGAGTTTACATTTGAAATGTGCATGTTTATTTATATAGATTTCAATAAAGCT >99987_99987_2_YEATS4-USP15_YEATS4_chr12_69756687_ENST00000247843_USP15_chr12_62719653_ENST00000353364_length(amino acids)=835AA_BP=90 MGPRDRSAVSEGSGDPASPGLFPWRRRLLPWDNMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNE VLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEEL NFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDK VVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLC TALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPVCLREKFRHSSYTHHTGSSLFGQPFLMA VPRNNTEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGG DNDSENGLCTEDTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFLALDWDPDLKKRYFDENAAEDFEKHESV EYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLI NPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQDTFSGTGFFPLDRETKGASAATG -------------------------------------------------------------- >99987_99987_3_YEATS4-USP15_YEATS4_chr12_69756687_ENST00000247843_USP15_chr12_62719653_ENST00000393654_length(transcript)=4422nt_BP=441nt CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGTATTAGTG ATAGAACAGAAAAATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAATGTGAAAAACTCAAATTACTGTCTTCCATCATATACC GCTTATAAGAACTATGATTATTCGGAACCTGGAAGAAACAATGAACAGCCAGGCCTCTGTGGCCTAAGTAACTTGGGAAATACGTGTTTC ATGAACTCAGCTATTCAGTGTTTGAGCAACACACCTCCACTTACTGAGTATTTCCTCAATGATAAGTATCAAGAAGAACTGAATTTTGAC AATCCCTTAGGAATGAGAGGTGAAATAGCTAAATCTTATGCCGAACTGATCAAGCAAATGTGGTCTGGAAAGTTTAGCTACGTCACCCCA AGAGCCTTTAAGACACAGGTAGGACGTTTTGCACCTCAGTTCTCTGGATATCAGCAGCAAGACTGTCAAGAACTGTTAGCTTTCCTATTA GATGGATTACATGAGGATTTGAATAGAATTAGGAAAAAACCATATATACAATTAAAAGATGCAGATGGAAGGCCAGATAAGGTGGTTGCC GAAGAAGCCTGGGAAAACCATTTAAAACGAAATGATTCTATCATAGTAGATATATTTCATGGCCTTTTCAAATCAACTTTAGTTTGTCCT GAGTGTGCTAAGATTTCAGTAACATTTGATCCTTTTTGTTACTTGACACTTCCATTGCCCATGAAAAAAGAACGCACCTTGGAAGTTTAC TTAGTTAGAATGGATCCACTTACCAAACCTATGCAGTACAAAGTGGTTGTCCCCAAAATTGGAAACATATTAGATCTTTGTACAGCATTG TCTGCTTTGTCAGGAATACCTGCAGATAAGATGATAGTTACTGATATATACAATCATAGATTTCACAGAATATTCGCTATGGATGAAAAC CTTAGTAGTATTATGGAACGGGATGATATTTATGTGTTTGAAATTAACATCAATAGGACAGAAGATACAGAGCACGTGATTATTCCTGTT TGCCTAAGAGAAAAATTCAGACACTCGAGTTATACCCACCATACTGGTTCTTCACTTTTTGGTCAGCCCTTTCTTATGGCTGTACCACGA AACAATACTGAAGACAAACTTTATAATCTCCTGCTCTTGAGAATGTGCCGATATGTCAAAATATCTACTGAAACTGAAGAAACTGAAGGA TCCCTACACTGCTGTAAGGACCAAAATATTAATGGGAATGGCCCAAATGGCATACATGAAGAAGGCTCACCAAGTGAAATGGAAACAGAT GAGCCAGATGATGAATCCAGCCAGGATCAAGAACTTCCCTCAGAGAATGAAAACAGTCAGTCTGAAGATTCAGTTGGAGGAGATAATGAT TCTGAAAATGGATTATGTACTGAGGATACTTGCAAAGGTCAACTCACGGGACACAAAAAACGATTGTTTACATTCCAGTTCAACAACTTA GGCAATACTGATATCAACTACATCAAAGATGATACCAGGCATATAAGATTTGATGATAGGCAGCTTAGGCTAGATGAAAGATCTTTTCTT GCTTTGGATTGGGATCCTGATTTGAAAAAAAGATATTTTGATGAAAATGCTGCTGAGGACTTTGAAAAACATGAAAGTGTGGAGTATAAA CCTCCTAAAAAACCCTTTGTGAAATTAAAAGATTGCATTGAACTTTTTACAACAAAAGAAAAGCTAGGTGCTGAAGATCCCTGGTATTGT CCGAATTGTAAAGAACATCAGCAAGCCACAAAGAAATTGGATTTATGGTCCCTGCCTCCAGTACTTGTAGTACATCTCAAGCGATTTTCT TACAGTCGATACATGAGAGACAAGTTGGATACCTTAGTTGATTTTCCTATCAATGACTTGGATATGTCGGAATTCTTAATTAATCCAAAT GCAGGTCCTTGCCGCTATAATCTGATTGCTGTTTCCAACCACTATGGAGGGATGGGAGGAGGACACTATACTGCTTTTGCAAAAAATAAA GATGATGGAAAATGGTACTATTTTGATGACAGTAGTGTCTCCACTGCATCTGAAGACCAAATTGTGTCCAAAGCAGCATATGTACTCTTC TACCAGAGACAAGACACTTTCAGTGGAACTGGCTTTTTTCCTCTTGACCGAGAAACTAAAGGTGCTTCAGCTGCCACTGGCATCCCATTA GAAAGTGATGAAGATAGCAATGATAATGACAATGATATAGAAAATGAAAACTGTATGCACACTAACTAATGAAAGTCCTAGAAGCCATAA AAGAGACACTTTCCTGCTGGTGGTATCTATGGAAATGATGAAGTTACCCACCACATTAAAACAAAAGTCTGAGATGGGGAGTTTCAGATA ACCGAATGTAAATCCTTTATCAGATTTTAACTTGTGCAGTACTTGAAGTGAAACACAATGAAAACTTTAACAGAAATTGTCTCTTAATAC ATTTACAGTCTTGTATTTACAAGCTAAATATATATAGGAAATCACAAATAAATCCCTTTTAAGTTTGCTGCTGTTTTGATTAATTATGTT TCCTTTAATTTTTTGGATGTGAGTTGATGACAAATGTTAAATTTGTGGATGTTGGTCATTTATTTTGCTCTAATAATACTGCAAGAAAAC TATGGCTGAACTTAGTTTTTGGATAATCTAGTTCATGTGCATTAGGCTGCCGTATATACTACTATGATATTTAGCTGCAGTATCAATGTG GCATAAATACTGCGGCAGCATTCTTCGAAAACCGCATTTTCAAATTTATCCCCGTAATCAATGTGGGCCTATTAAAAAACCAAATCATGA TACAAGAAACAACCTTGGAAAAGTTATTTCCCTTTGTAATACCTTTAAAAATCCAGAGTATTATATTCATTTTACTGCCACTGTGGAAAC AGGTTCTAGATTTCATACTCCATCTAAAGTCATTTTTCAGTTACATGTAAGTATTATTTACTGCTATTGGGATCTATTCTTCAGATATTC AAAAACATTTTTTGCTTTAAAATGCATATCTTTAATTGGGTGTTGGTCCAAAATTAAAATTTTTGCTGTCTGTTTTTCTCTACCCCATTT TGTGGTAATTTGGCAACTTGAGCTCTCCCAATTATTGTAATATAAGGACAGACATAATAGTATTCTGTACCCATAGTAATAATTGCATCA AGCTTAGATGAGAAATTTTTTTCATATACTGGCCTTTAAATCATTAATGGACAATTGGCTATAAAGGTAGGTCTGTTAACTTTCTTTGTG TGTTCCTGATGGAATTCACCATAGCCTTACAGCTTTTCTCAGAAGGTAACTTGTTATAAGAGAAATGGCATTTGCATGTTCCAGAGTCAG AACCTGTACAGTATATAAAGCATAAACACCTTGAATTTGATTTTAGTTCACCACATTCAAGGATCCAGGATGCCAAAAATATGTGTGAAC ATTTGAAACATTTTTATTTGCTGCTTTTTCCCTTTGATATAGTTGAAAGAATGTATTGTAAATTGGCATACAATACTGCCTTTAATAGAA AACCTAAATGCTGGGGCACATTTCACATATCGACTACCTGAGAAATTGCTTTGTGTCCCACTGTTATTAAAGCAAAAAGTATAATGTTCT TCACTTGAACTAATCAAATACAATAGATTATAAATTGTGTATTGTAAATAAAAGTTCACTCTGTGAGTGCACATTTTGGTAAATTATTTA TTTATGTTAGCATTTAAAAGTTTAAAAAAAATGCATTTGACCAGGATAAATGAGGTATGTTGATCATGGCTTTGCTTTATATCTTGATAT TAAAGCTGGTTTATCATCCTGGTATTTTAAAAGCTGCTTTGGGGTTTTTTTTTTCTTTTTTTTTTTTTTAATGTAAACTAACCTCCTGCA TGACAGAGGTTAAAATTTTGTCTGCACTTGAGTTCACTTGAGTTTACATTTGAAATGTGCATGTTTATTTATATAGATTTCAATAAAGCT >99987_99987_3_YEATS4-USP15_YEATS4_chr12_69756687_ENST00000247843_USP15_chr12_62719653_ENST00000393654_length(amino acids)=835AA_BP=90 MGPRDRSAVSEGSGDPASPGLFPWRRRLLPWDNMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNE VLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEEL NFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDK VVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLC TALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPVCLREKFRHSSYTHHTGSSLFGQPFLMA VPRNNTEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGG DNDSENGLCTEDTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFLALDWDPDLKKRYFDENAAEDFEKHESV EYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLI NPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQDTFSGTGFFPLDRETKGASAATG -------------------------------------------------------------- >99987_99987_4_YEATS4-USP15_YEATS4_chr12_69756687_ENST00000548020_USP15_chr12_62719653_ENST00000280377_length(transcript)=4503nt_BP=434nt CCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAGCACAGTC GGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCGCGCGACA GGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAATATGTTCA AGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGT ATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGTATTAGTGATAGAAC AGAAAAATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAAGTCCCCAGGTGCATCCAATTTTTCAACTTTACCAAAGATCTCTC CTTCATCTCTATCAAATAATTATAACAACATGAACAACAGAAATGTGAAAAACTCAAATTACTGTCTTCCATCATATACCGCTTATAAGA ACTATGATTATTCGGAACCTGGAAGAAACAATGAACAGCCAGGCCTCTGTGGCCTAAGTAACTTGGGAAATACGTGTTTCATGAACTCAG CTATTCAGTGTTTGAGCAACACACCTCCACTTACTGAGTATTTCCTCAATGATAAGTATCAAGAAGAACTGAATTTTGACAATCCCTTAG GAATGAGAGGTGAAATAGCTAAATCTTATGCCGAACTGATCAAGCAAATGTGGTCTGGAAAGTTTAGCTACGTCACCCCAAGAGCCTTTA AGACACAGGTAGGACGTTTTGCACCTCAGTTCTCTGGATATCAGCAGCAAGACTGTCAAGAACTGTTAGCTTTCCTATTAGATGGATTAC ATGAGGATTTGAATAGAATTAGGAAAAAACCATATATACAATTAAAAGATGCAGATGGAAGGCCAGATAAGGTGGTTGCCGAAGAAGCCT GGGAAAACCATTTAAAACGAAATGATTCTATCATAGTAGATATATTTCATGGCCTTTTCAAATCAACTTTAGTTTGTCCTGAGTGTGCTA AGATTTCAGTAACATTTGATCCTTTTTGTTACTTGACACTTCCATTGCCCATGAAAAAAGAACGCACCTTGGAAGTTTACTTAGTTAGAA TGGATCCACTTACCAAACCTATGCAGTACAAAGTGGTTGTCCCCAAAATTGGAAACATATTAGATCTTTGTACAGCATTGTCTGCTTTGT CAGGAATACCTGCAGATAAGATGATAGTTACTGATATATACAATCATAGATTTCACAGAATATTCGCTATGGATGAAAACCTTAGTAGTA TTATGGAACGGGATGATATTTATGTGTTTGAAATTAACATCAATAGGACAGAAGATACAGAGCACGTGATTATTCCTGTTTGCCTAAGAG AAAAATTCAGACACTCGAGTTATACCCACCATACTGGTTCTTCACTTTTTGGTCAGCCCTTTCTTATGGCTGTACCACGAAACAATACTG AAGACAAACTTTATAATCTCCTGCTCTTGAGAATGTGCCGATATGTCAAAATATCTACTGAAACTGAAGAAACTGAAGGATCCCTACACT GCTGTAAGGACCAAAATATTAATGGGAATGGCCCAAATGGCATACATGAAGAAGGCTCACCAAGTGAAATGGAAACAGATGAGCCAGATG ATGAATCCAGCCAGGATCAAGAACTTCCCTCAGAGAATGAAAACAGTCAGTCTGAAGATTCAGTTGGAGGAGATAATGATTCTGAAAATG GATTATGTACTGAGGATACTTGCAAAGGTCAACTCACGGGACACAAAAAACGATTGTTTACATTCCAGTTCAACAACTTAGGCAATACTG ATATCAACTACATCAAAGATGATACCAGGCATATAAGATTTGATGATAGGCAGCTTAGGCTAGATGAAAGATCTTTTCTTGCTTTGGATT GGGATCCTGATTTGAAAAAAAGATATTTTGATGAAAATGCTGCTGAGGACTTTGAAAAACATGAAAGTGTGGAGTATAAACCTCCTAAAA AACCCTTTGTGAAATTAAAAGATTGCATTGAACTTTTTACAACAAAAGAAAAGCTAGGTGCTGAAGATCCCTGGTATTGTCCGAATTGTA AAGAACATCAGCAAGCCACAAAGAAATTGGATTTATGGTCCCTGCCTCCAGTACTTGTAGTACATCTCAAGCGATTTTCTTACAGTCGAT ACATGAGAGACAAGTTGGATACCTTAGTTGATTTTCCTATCAATGACTTGGATATGTCGGAATTCTTAATTAATCCAAATGCAGGTCCTT GCCGCTATAATCTGATTGCTGTTTCCAACCACTATGGAGGGATGGGAGGAGGACACTATACTGCTTTTGCAAAAAATAAAGATGATGGAA AATGGTACTATTTTGATGACAGTAGTGTCTCCACTGCATCTGAAGACCAAATTGTGTCCAAAGCAGCATATGTACTCTTCTACCAGAGAC AAGACACTTTCAGTGGAACTGGCTTTTTTCCTCTTGACCGAGAAACTAAAGGTGCTTCAGCTGCCACTGGCATCCCATTAGAAAGTGATG AAGATAGCAATGATAATGACAATGATATAGAAAATGAAAACTGTATGCACACTAACTAATGAAAGTCCTAGAAGCCATAAAAGAGACACT TTCCTGCTGGTGGTATCTATGGAAATGATGAAGTTACCCACCACATTAAAACAAAAGTCTGAGATGGGGAGTTTCAGATAACCGAATGTA AATCCTTTATCAGATTTTAACTTGTGCAGTACTTGAAGTGAAACACAATGAAAACTTTAACAGAAATTGTCTCTTAATACATTTACAGTC TTGTATTTACAAGCTAAATATATATAGGAAATCACAAATAAATCCCTTTTAAGTTTGCTGCTGTTTTGATTAATTATGTTTCCTTTAATT TTTTGGATGTGAGTTGATGACAAATGTTAAATTTGTGGATGTTGGTCATTTATTTTGCTCTAATAATACTGCAAGAAAACTATGGCTGAA CTTAGTTTTTGGATAATCTAGTTCATGTGCATTAGGCTGCCGTATATACTACTATGATATTTAGCTGCAGTATCAATGTGGCATAAATAC TGCGGCAGCATTCTTCGAAAACCGCATTTTCAAATTTATCCCCGTAATCAATGTGGGCCTATTAAAAAACCAAATCATGATACAAGAAAC AACCTTGGAAAAGTTATTTCCCTTTGTAATACCTTTAAAAATCCAGAGTATTATATTCATTTTACTGCCACTGTGGAAACAGGTTCTAGA TTTCATACTCCATCTAAAGTCATTTTTCAGTTACATGTAAGTATTATTTACTGCTATTGGGATCTATTCTTCAGATATTCAAAAACATTT TTTGCTTTAAAATGCATATCTTTAATTGGGTGTTGGTCCAAAATTAAAATTTTTGCTGTCTGTTTTTCTCTACCCCATTTTGTGGTAATT TGGCAACTTGAGCTCTCCCAATTATTGTAATATAAGGACAGACATAATAGTATTCTGTACCCATAGTAATAATTGCATCAAGCTTAGATG AGAAATTTTTTTCATATACTGGCCTTTAAATCATTAATGGACAATTGGCTATAAAGGTAGGTCTGTTAACTTTCTTTGTGTGTTCCTGAT GGAATTCACCATAGCCTTACAGCTTTTCTCAGAAGGTAACTTGTTATAAGAGAAATGGCATTTGCATGTTCCAGAGTCAGAACCTGTACA GTATATAAAGCATAAACACCTTGAATTTGATTTTAGTTCACCACATTCAAGGATCCAGGATGCCAAAAATATGTGTGAACATTTGAAACA TTTTTATTTGCTGCTTTTTCCCTTTGATATAGTTGAAAGAATGTATTGTAAATTGGCATACAATACTGCCTTTAATAGAAAACCTAAATG CTGGGGCACATTTCACATATCGACTACCTGAGAAATTGCTTTGTGTCCCACTGTTATTAAAGCAAAAAGTATAATGTTCTTCACTTGAAC TAATCAAATACAATAGATTATAAATTGTGTATTGTAAATAAAAGTTCACTCTGTGAGTGCACATTTTGGTAAATTATTTATTTATGTTAG CATTTAAAAGTTTAAAAAAAATGCATTTGACCAGGATAAATGAGGTATGTTGATCATGGCTTTGCTTTATATCTTGATATTAAAGCTGGT TTATCATCCTGGTATTTTAAAAGCTGCTTTGGGGTTTTTTTTTTCTTTTTTTTTTTTTTAATGTAAACTAACCTCCTGCATGACAGAGGT TAAAATTTTGTCTGCACTTGAGTTCACTTGAGTTTACATTTGAAATGTGCATGTTTATTTATATAGATTTCAATAAAGCTATTCAAGGCC >99987_99987_4_YEATS4-USP15_YEATS4_chr12_69756687_ENST00000548020_USP15_chr12_62719653_ENST00000280377_length(amino acids)=864AA_BP=90 MGPRDRSAVSEGSGDPASPGLFPWRRRLLPWDNMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNE VLVIEQKNEDGTWPRGPSTPKSPGASNFSTLPKISPSSLSNNYNNMNNRNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNT CFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAF LLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLE VYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVII PVCLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPNGIHEEGSPSEME TDEPDDESSQDQELPSENENSQSEDSVGGDNDSENGLCTEDTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERS FLALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKR FSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYV -------------------------------------------------------------- >99987_99987_5_YEATS4-USP15_YEATS4_chr12_69756687_ENST00000548020_USP15_chr12_62719653_ENST00000353364_length(transcript)=4416nt_BP=434nt CCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAGCACAGTC GGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCGCGCGACA GGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAATATGTTCA AGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGT ATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGTATTAGTGATAGAAC AGAAAAATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAATGTGAAAAACTCAAATTACTGTCTTCCATCATATACCGCTTATA AGAACTATGATTATTCGGAACCTGGAAGAAACAATGAACAGCCAGGCCTCTGTGGCCTAAGTAACTTGGGAAATACGTGTTTCATGAACT CAGCTATTCAGTGTTTGAGCAACACACCTCCACTTACTGAGTATTTCCTCAATGATAAGTATCAAGAAGAACTGAATTTTGACAATCCCT TAGGAATGAGAGGTGAAATAGCTAAATCTTATGCCGAACTGATCAAGCAAATGTGGTCTGGAAAGTTTAGCTACGTCACCCCAAGAGCCT TTAAGACACAGGTAGGACGTTTTGCACCTCAGTTCTCTGGATATCAGCAGCAAGACTGTCAAGAACTGTTAGCTTTCCTATTAGATGGAT TACATGAGGATTTGAATAGAATTAGGAAAAAACCATATATACAATTAAAAGATGCAGATGGAAGGCCAGATAAGGTGGTTGCCGAAGAAG CCTGGGAAAACCATTTAAAACGAAATGATTCTATCATAGTAGATATATTTCATGGCCTTTTCAAATCAACTTTAGTTTGTCCTGAGTGTG CTAAGATTTCAGTAACATTTGATCCTTTTTGTTACTTGACACTTCCATTGCCCATGAAAAAAGAACGCACCTTGGAAGTTTACTTAGTTA GAATGGATCCACTTACCAAACCTATGCAGTACAAAGTGGTTGTCCCCAAAATTGGAAACATATTAGATCTTTGTACAGCATTGTCTGCTT TGTCAGGAATACCTGCAGATAAGATGATAGTTACTGATATATACAATCATAGATTTCACAGAATATTCGCTATGGATGAAAACCTTAGTA GTATTATGGAACGGGATGATATTTATGTGTTTGAAATTAACATCAATAGGACAGAAGATACAGAGCACGTGATTATTCCTGTTTGCCTAA GAGAAAAATTCAGACACTCGAGTTATACCCACCATACTGGTTCTTCACTTTTTGGTCAGCCCTTTCTTATGGCTGTACCACGAAACAATA CTGAAGACAAACTTTATAATCTCCTGCTCTTGAGAATGTGCCGATATGTCAAAATATCTACTGAAACTGAAGAAACTGAAGGATCCCTAC ACTGCTGTAAGGACCAAAATATTAATGGGAATGGCCCAAATGGCATACATGAAGAAGGCTCACCAAGTGAAATGGAAACAGATGAGCCAG ATGATGAATCCAGCCAGGATCAAGAACTTCCCTCAGAGAATGAAAACAGTCAGTCTGAAGATTCAGTTGGAGGAGATAATGATTCTGAAA ATGGATTATGTACTGAGGATACTTGCAAAGGTCAACTCACGGGACACAAAAAACGATTGTTTACATTCCAGTTCAACAACTTAGGCAATA CTGATATCAACTACATCAAAGATGATACCAGGCATATAAGATTTGATGATAGGCAGCTTAGGCTAGATGAAAGATCTTTTCTTGCTTTGG ATTGGGATCCTGATTTGAAAAAAAGATATTTTGATGAAAATGCTGCTGAGGACTTTGAAAAACATGAAAGTGTGGAGTATAAACCTCCTA AAAAACCCTTTGTGAAATTAAAAGATTGCATTGAACTTTTTACAACAAAAGAAAAGCTAGGTGCTGAAGATCCCTGGTATTGTCCGAATT GTAAAGAACATCAGCAAGCCACAAAGAAATTGGATTTATGGTCCCTGCCTCCAGTACTTGTAGTACATCTCAAGCGATTTTCTTACAGTC GATACATGAGAGACAAGTTGGATACCTTAGTTGATTTTCCTATCAATGACTTGGATATGTCGGAATTCTTAATTAATCCAAATGCAGGTC CTTGCCGCTATAATCTGATTGCTGTTTCCAACCACTATGGAGGGATGGGAGGAGGACACTATACTGCTTTTGCAAAAAATAAAGATGATG GAAAATGGTACTATTTTGATGACAGTAGTGTCTCCACTGCATCTGAAGACCAAATTGTGTCCAAAGCAGCATATGTACTCTTCTACCAGA GACAAGACACTTTCAGTGGAACTGGCTTTTTTCCTCTTGACCGAGAAACTAAAGGTGCTTCAGCTGCCACTGGCATCCCATTAGAAAGTG ATGAAGATAGCAATGATAATGACAATGATATAGAAAATGAAAACTGTATGCACACTAACTAATGAAAGTCCTAGAAGCCATAAAAGAGAC ACTTTCCTGCTGGTGGTATCTATGGAAATGATGAAGTTACCCACCACATTAAAACAAAAGTCTGAGATGGGGAGTTTCAGATAACCGAAT GTAAATCCTTTATCAGATTTTAACTTGTGCAGTACTTGAAGTGAAACACAATGAAAACTTTAACAGAAATTGTCTCTTAATACATTTACA GTCTTGTATTTACAAGCTAAATATATATAGGAAATCACAAATAAATCCCTTTTAAGTTTGCTGCTGTTTTGATTAATTATGTTTCCTTTA ATTTTTTGGATGTGAGTTGATGACAAATGTTAAATTTGTGGATGTTGGTCATTTATTTTGCTCTAATAATACTGCAAGAAAACTATGGCT GAACTTAGTTTTTGGATAATCTAGTTCATGTGCATTAGGCTGCCGTATATACTACTATGATATTTAGCTGCAGTATCAATGTGGCATAAA TACTGCGGCAGCATTCTTCGAAAACCGCATTTTCAAATTTATCCCCGTAATCAATGTGGGCCTATTAAAAAACCAAATCATGATACAAGA AACAACCTTGGAAAAGTTATTTCCCTTTGTAATACCTTTAAAAATCCAGAGTATTATATTCATTTTACTGCCACTGTGGAAACAGGTTCT AGATTTCATACTCCATCTAAAGTCATTTTTCAGTTACATGTAAGTATTATTTACTGCTATTGGGATCTATTCTTCAGATATTCAAAAACA TTTTTTGCTTTAAAATGCATATCTTTAATTGGGTGTTGGTCCAAAATTAAAATTTTTGCTGTCTGTTTTTCTCTACCCCATTTTGTGGTA ATTTGGCAACTTGAGCTCTCCCAATTATTGTAATATAAGGACAGACATAATAGTATTCTGTACCCATAGTAATAATTGCATCAAGCTTAG ATGAGAAATTTTTTTCATATACTGGCCTTTAAATCATTAATGGACAATTGGCTATAAAGGTAGGTCTGTTAACTTTCTTTGTGTGTTCCT GATGGAATTCACCATAGCCTTACAGCTTTTCTCAGAAGGTAACTTGTTATAAGAGAAATGGCATTTGCATGTTCCAGAGTCAGAACCTGT ACAGTATATAAAGCATAAACACCTTGAATTTGATTTTAGTTCACCACATTCAAGGATCCAGGATGCCAAAAATATGTGTGAACATTTGAA ACATTTTTATTTGCTGCTTTTTCCCTTTGATATAGTTGAAAGAATGTATTGTAAATTGGCATACAATACTGCCTTTAATAGAAAACCTAA ATGCTGGGGCACATTTCACATATCGACTACCTGAGAAATTGCTTTGTGTCCCACTGTTATTAAAGCAAAAAGTATAATGTTCTTCACTTG AACTAATCAAATACAATAGATTATAAATTGTGTATTGTAAATAAAAGTTCACTCTGTGAGTGCACATTTTGGTAAATTATTTATTTATGT TAGCATTTAAAAGTTTAAAAAAAATGCATTTGACCAGGATAAATGAGGTATGTTGATCATGGCTTTGCTTTATATCTTGATATTAAAGCT GGTTTATCATCCTGGTATTTTAAAAGCTGCTTTGGGGTTTTTTTTTTCTTTTTTTTTTTTTTAATGTAAACTAACCTCCTGCATGACAGA GGTTAAAATTTTGTCTGCACTTGAGTTCACTTGAGTTTACATTTGAAATGTGCATGTTTATTTATATAGATTTCAATAAAGCTATTCAAG >99987_99987_5_YEATS4-USP15_YEATS4_chr12_69756687_ENST00000548020_USP15_chr12_62719653_ENST00000353364_length(amino acids)=835AA_BP=90 MGPRDRSAVSEGSGDPASPGLFPWRRRLLPWDNMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNE VLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEEL NFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDK VVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLC TALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPVCLREKFRHSSYTHHTGSSLFGQPFLMA VPRNNTEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGG DNDSENGLCTEDTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFLALDWDPDLKKRYFDENAAEDFEKHESV EYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLI NPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQDTFSGTGFFPLDRETKGASAATG -------------------------------------------------------------- >99987_99987_6_YEATS4-USP15_YEATS4_chr12_69756687_ENST00000548020_USP15_chr12_62719653_ENST00000393654_length(transcript)=4415nt_BP=434nt CCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAGCACAGTC GGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCGCGCGACA GGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAATATGTTCA AGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGT ATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGTATTAGTGATAGAAC AGAAAAATGAAGATGGAACATGGCCAAGGGGTCCTTCTACTCCTAATGTGAAAAACTCAAATTACTGTCTTCCATCATATACCGCTTATA AGAACTATGATTATTCGGAACCTGGAAGAAACAATGAACAGCCAGGCCTCTGTGGCCTAAGTAACTTGGGAAATACGTGTTTCATGAACT CAGCTATTCAGTGTTTGAGCAACACACCTCCACTTACTGAGTATTTCCTCAATGATAAGTATCAAGAAGAACTGAATTTTGACAATCCCT TAGGAATGAGAGGTGAAATAGCTAAATCTTATGCCGAACTGATCAAGCAAATGTGGTCTGGAAAGTTTAGCTACGTCACCCCAAGAGCCT TTAAGACACAGGTAGGACGTTTTGCACCTCAGTTCTCTGGATATCAGCAGCAAGACTGTCAAGAACTGTTAGCTTTCCTATTAGATGGAT TACATGAGGATTTGAATAGAATTAGGAAAAAACCATATATACAATTAAAAGATGCAGATGGAAGGCCAGATAAGGTGGTTGCCGAAGAAG CCTGGGAAAACCATTTAAAACGAAATGATTCTATCATAGTAGATATATTTCATGGCCTTTTCAAATCAACTTTAGTTTGTCCTGAGTGTG CTAAGATTTCAGTAACATTTGATCCTTTTTGTTACTTGACACTTCCATTGCCCATGAAAAAAGAACGCACCTTGGAAGTTTACTTAGTTA GAATGGATCCACTTACCAAACCTATGCAGTACAAAGTGGTTGTCCCCAAAATTGGAAACATATTAGATCTTTGTACAGCATTGTCTGCTT TGTCAGGAATACCTGCAGATAAGATGATAGTTACTGATATATACAATCATAGATTTCACAGAATATTCGCTATGGATGAAAACCTTAGTA GTATTATGGAACGGGATGATATTTATGTGTTTGAAATTAACATCAATAGGACAGAAGATACAGAGCACGTGATTATTCCTGTTTGCCTAA GAGAAAAATTCAGACACTCGAGTTATACCCACCATACTGGTTCTTCACTTTTTGGTCAGCCCTTTCTTATGGCTGTACCACGAAACAATA CTGAAGACAAACTTTATAATCTCCTGCTCTTGAGAATGTGCCGATATGTCAAAATATCTACTGAAACTGAAGAAACTGAAGGATCCCTAC ACTGCTGTAAGGACCAAAATATTAATGGGAATGGCCCAAATGGCATACATGAAGAAGGCTCACCAAGTGAAATGGAAACAGATGAGCCAG ATGATGAATCCAGCCAGGATCAAGAACTTCCCTCAGAGAATGAAAACAGTCAGTCTGAAGATTCAGTTGGAGGAGATAATGATTCTGAAA ATGGATTATGTACTGAGGATACTTGCAAAGGTCAACTCACGGGACACAAAAAACGATTGTTTACATTCCAGTTCAACAACTTAGGCAATA CTGATATCAACTACATCAAAGATGATACCAGGCATATAAGATTTGATGATAGGCAGCTTAGGCTAGATGAAAGATCTTTTCTTGCTTTGG ATTGGGATCCTGATTTGAAAAAAAGATATTTTGATGAAAATGCTGCTGAGGACTTTGAAAAACATGAAAGTGTGGAGTATAAACCTCCTA AAAAACCCTTTGTGAAATTAAAAGATTGCATTGAACTTTTTACAACAAAAGAAAAGCTAGGTGCTGAAGATCCCTGGTATTGTCCGAATT GTAAAGAACATCAGCAAGCCACAAAGAAATTGGATTTATGGTCCCTGCCTCCAGTACTTGTAGTACATCTCAAGCGATTTTCTTACAGTC GATACATGAGAGACAAGTTGGATACCTTAGTTGATTTTCCTATCAATGACTTGGATATGTCGGAATTCTTAATTAATCCAAATGCAGGTC CTTGCCGCTATAATCTGATTGCTGTTTCCAACCACTATGGAGGGATGGGAGGAGGACACTATACTGCTTTTGCAAAAAATAAAGATGATG GAAAATGGTACTATTTTGATGACAGTAGTGTCTCCACTGCATCTGAAGACCAAATTGTGTCCAAAGCAGCATATGTACTCTTCTACCAGA GACAAGACACTTTCAGTGGAACTGGCTTTTTTCCTCTTGACCGAGAAACTAAAGGTGCTTCAGCTGCCACTGGCATCCCATTAGAAAGTG ATGAAGATAGCAATGATAATGACAATGATATAGAAAATGAAAACTGTATGCACACTAACTAATGAAAGTCCTAGAAGCCATAAAAGAGAC ACTTTCCTGCTGGTGGTATCTATGGAAATGATGAAGTTACCCACCACATTAAAACAAAAGTCTGAGATGGGGAGTTTCAGATAACCGAAT GTAAATCCTTTATCAGATTTTAACTTGTGCAGTACTTGAAGTGAAACACAATGAAAACTTTAACAGAAATTGTCTCTTAATACATTTACA GTCTTGTATTTACAAGCTAAATATATATAGGAAATCACAAATAAATCCCTTTTAAGTTTGCTGCTGTTTTGATTAATTATGTTTCCTTTA ATTTTTTGGATGTGAGTTGATGACAAATGTTAAATTTGTGGATGTTGGTCATTTATTTTGCTCTAATAATACTGCAAGAAAACTATGGCT GAACTTAGTTTTTGGATAATCTAGTTCATGTGCATTAGGCTGCCGTATATACTACTATGATATTTAGCTGCAGTATCAATGTGGCATAAA TACTGCGGCAGCATTCTTCGAAAACCGCATTTTCAAATTTATCCCCGTAATCAATGTGGGCCTATTAAAAAACCAAATCATGATACAAGA AACAACCTTGGAAAAGTTATTTCCCTTTGTAATACCTTTAAAAATCCAGAGTATTATATTCATTTTACTGCCACTGTGGAAACAGGTTCT AGATTTCATACTCCATCTAAAGTCATTTTTCAGTTACATGTAAGTATTATTTACTGCTATTGGGATCTATTCTTCAGATATTCAAAAACA TTTTTTGCTTTAAAATGCATATCTTTAATTGGGTGTTGGTCCAAAATTAAAATTTTTGCTGTCTGTTTTTCTCTACCCCATTTTGTGGTA ATTTGGCAACTTGAGCTCTCCCAATTATTGTAATATAAGGACAGACATAATAGTATTCTGTACCCATAGTAATAATTGCATCAAGCTTAG ATGAGAAATTTTTTTCATATACTGGCCTTTAAATCATTAATGGACAATTGGCTATAAAGGTAGGTCTGTTAACTTTCTTTGTGTGTTCCT GATGGAATTCACCATAGCCTTACAGCTTTTCTCAGAAGGTAACTTGTTATAAGAGAAATGGCATTTGCATGTTCCAGAGTCAGAACCTGT ACAGTATATAAAGCATAAACACCTTGAATTTGATTTTAGTTCACCACATTCAAGGATCCAGGATGCCAAAAATATGTGTGAACATTTGAA ACATTTTTATTTGCTGCTTTTTCCCTTTGATATAGTTGAAAGAATGTATTGTAAATTGGCATACAATACTGCCTTTAATAGAAAACCTAA ATGCTGGGGCACATTTCACATATCGACTACCTGAGAAATTGCTTTGTGTCCCACTGTTATTAAAGCAAAAAGTATAATGTTCTTCACTTG AACTAATCAAATACAATAGATTATAAATTGTGTATTGTAAATAAAAGTTCACTCTGTGAGTGCACATTTTGGTAAATTATTTATTTATGT TAGCATTTAAAAGTTTAAAAAAAATGCATTTGACCAGGATAAATGAGGTATGTTGATCATGGCTTTGCTTTATATCTTGATATTAAAGCT GGTTTATCATCCTGGTATTTTAAAAGCTGCTTTGGGGTTTTTTTTTTCTTTTTTTTTTTTTTAATGTAAACTAACCTCCTGCATGACAGA GGTTAAAATTTTGTCTGCACTTGAGTTCACTTGAGTTTACATTTGAAATGTGCATGTTTATTTATATAGATTTCAATAAAGCTATTCAAG >99987_99987_6_YEATS4-USP15_YEATS4_chr12_69756687_ENST00000548020_USP15_chr12_62719653_ENST00000393654_length(amino acids)=835AA_BP=90 MGPRDRSAVSEGSGDPASPGLFPWRRRLLPWDNMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNE VLVIEQKNEDGTWPRGPSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEEL NFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDK VVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLC TALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVIIPVCLREKFRHSSYTHHTGSSLFGQPFLMA VPRNNTEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGG DNDSENGLCTEDTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFLALDWDPDLKKRYFDENAAEDFEKHESV EYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFLI NPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQDTFSGTGFFPLDRETKGASAATG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for YEATS4-USP15 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | YEATS4 | chr12:69756687 | chr12:62719653 | ENST00000247843 | + | 2 | 7 | 163_227 | 57.0 | 228.0 | MLLT10 |
| Hgene | YEATS4 | chr12:69756687 | chr12:62719653 | ENST00000247843 | + | 2 | 7 | 168_227 | 57.0 | 228.0 | TACC1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for YEATS4-USP15 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for YEATS4-USP15 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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