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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:YWHAE-SLC43A2

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: YWHAE-SLC43A2
FusionPDB ID: 100157
FusionGDB2.0 ID: 100157
HgeneTgene
Gene symbol

YWHAE

SLC43A2

Gene ID

7531

124935

Gene nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilonsolute carrier family 43 member 2
Synonyms14-3-3E|HEL2|KCIP-1|MDCR|MDSLAT4
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Description14-3-3 protein epsilon14-3-3 epsilonepididymis luminal protein 2mitochondrial import stimulation factor L subunitprotein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptidetyrosine large neutral amino acids transporter small subunit 4L-type amino acid transporter 4solute carrier family 43 (amino acid system L transporter), member 2
Modification date2020032720200313
UniProtAcc

P62258

Main function of 5'-partner protein: FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326}.		.
Ensembl transtripts involved in fusion geneENST idsENST00000264335, ENST00000571732, 
ENST00000573026, ENST00000575977, 
ENST00000498643, 		ENST00000574274, 
ENST00000301335, ENST00000382147, 
ENST00000412517, ENST00000571650, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score28 X 9 X 15=378010 X 10 X 6=600
# samples 4216
** MAII scorelog2(42/3780*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/600*10)=-1.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: YWHAE [Title/Abstract] AND SLC43A2 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: YWHAE [Title/Abstract] AND SLC43A2 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)YWHAE(1257505)-SLC43A2(1489345), # samples:2
Anticipated loss of major functional domain due to fusion event.YWHAE-SLC43A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
YWHAE-SLC43A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
YWHAE-SLC43A2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
YWHAE-SLC43A2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
YWHAE-SLC43A2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYWHAE

GO:0000165

MAPK cascade

12917326

HgeneYWHAE

GO:0034605

cellular response to heat

12917326

HgeneYWHAE

GO:0046827

positive regulation of protein export from nucleus

12917326

HgeneYWHAE

GO:0051480

regulation of cytosolic calcium ion concentration

18029012

HgeneYWHAE

GO:0060306

regulation of membrane repolarization

11953308

HgeneYWHAE

GO:1901016

regulation of potassium ion transmembrane transporter activity

11953308

HgeneYWHAE

GO:1901020

negative regulation of calcium ion transmembrane transporter activity

18029012

HgeneYWHAE

GO:1902309

negative regulation of peptidyl-serine dephosphorylation

11953308

HgeneYWHAE

GO:1905913

negative regulation of calcium ion export across plasma membrane

18029012



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:1257505/chr17:1489345)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across YWHAE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC43A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264335YWHAEchr171257504-ENST00000301335SLC43A2chr171489345-79529832021614470
ENST00000264335YWHAEchr171257504-ENST00000571650SLC43A2chr171489345-28409832021614470
ENST00000264335YWHAEchr171257504-ENST00000382147SLC43A2chr171489345-28159832021092296
ENST00000264335YWHAEchr171257504-ENST00000412517SLC43A2chr171489345-17189832021614470
ENST00000264335YWHAEchr171303340-ENST00000301335SLC43A2chr171496573-78783322008266580
ENST00000264335YWHAEchr171303340-ENST00000571650SLC43A2chr171496573-27783322020266584
ENST00000264335YWHAEchr171303340-ENST00000382147SLC43A2chr171496573-27533322020266584
ENST00000264335YWHAEchr171303340-ENST00000412517SLC43A2chr171496573-16443321609266447
ENST00000573026YWHAEchr171303340-ENST00000301335SLC43A2chr171496573-7681135181169580
ENST00000573026YWHAEchr171303340-ENST00000571650SLC43A2chr171496573-2581135182369584
ENST00000573026YWHAEchr171303340-ENST00000382147SLC43A2chr171496573-2556135182369584
ENST00000573026YWHAEchr171303340-ENST00000412517SLC43A2chr171496573-1447135141269447
ENST00000575977YWHAEchr171303340-ENST00000301335SLC43A2chr171496573-77141681844102580
ENST00000575977YWHAEchr171303340-ENST00000571650SLC43A2chr171496573-26141681856102584
ENST00000575977YWHAEchr171303340-ENST00000382147SLC43A2chr171496573-25891681856102584
ENST00000575977YWHAEchr171303340-ENST00000412517SLC43A2chr171496573-14801681445102447
ENST00000264335YWHAEchr171257505-ENST00000301335SLC43A2chr171489345-79529832021614470
ENST00000264335YWHAEchr171257505-ENST00000571650SLC43A2chr171489345-28409832021614470
ENST00000264335YWHAEchr171257505-ENST00000382147SLC43A2chr171489345-28159832021092296
ENST00000264335YWHAEchr171257505-ENST00000412517SLC43A2chr171489345-17189832021614470
ENST00000264335YWHAEchr171303341-ENST00000301335SLC43A2chr171496573-78783322008266580
ENST00000264335YWHAEchr171303341-ENST00000571650SLC43A2chr171496573-27783322020266584
ENST00000264335YWHAEchr171303341-ENST00000382147SLC43A2chr171496573-27533322020266584
ENST00000264335YWHAEchr171303341-ENST00000412517SLC43A2chr171496573-16443321609266447
ENST00000573026YWHAEchr171303341-ENST00000301335SLC43A2chr171496573-7681135181169580
ENST00000573026YWHAEchr171303341-ENST00000571650SLC43A2chr171496573-2581135182369584
ENST00000573026YWHAEchr171303341-ENST00000382147SLC43A2chr171496573-2556135182369584
ENST00000573026YWHAEchr171303341-ENST00000412517SLC43A2chr171496573-1447135141269447
ENST00000575977YWHAEchr171303341-ENST00000301335SLC43A2chr171496573-77141681844102580
ENST00000575977YWHAEchr171303341-ENST00000571650SLC43A2chr171496573-26141681856102584
ENST00000575977YWHAEchr171303341-ENST00000382147SLC43A2chr171496573-25891681856102584
ENST00000575977YWHAEchr171303341-ENST00000412517SLC43A2chr171496573-14801681445102447

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264335ENST00000301335YWHAEchr171257504-SLC43A2chr171489345-0.0031574590.9968425
ENST00000264335ENST00000571650YWHAEchr171257504-SLC43A2chr171489345-0.0042988450.99570113
ENST00000264335ENST00000382147YWHAEchr171257504-SLC43A2chr171489345-0.0016845590.99831545
ENST00000264335ENST00000412517YWHAEchr171257504-SLC43A2chr171489345-0.00368840.9963116
ENST00000264335ENST00000301335YWHAEchr171303340-SLC43A2chr171496573-0.0290818810.97091806
ENST00000264335ENST00000571650YWHAEchr171303340-SLC43A2chr171496573-0.039046180.96095383
ENST00000264335ENST00000382147YWHAEchr171303340-SLC43A2chr171496573-0.0455442440.9544558
ENST00000264335ENST00000412517YWHAEchr171303340-SLC43A2chr171496573-0.041616740.95838326
ENST00000573026ENST00000301335YWHAEchr171303340-SLC43A2chr171496573-0.027945280.9720548
ENST00000573026ENST00000571650YWHAEchr171303340-SLC43A2chr171496573-0.037969880.9620301
ENST00000573026ENST00000382147YWHAEchr171303340-SLC43A2chr171496573-0.044842010.955158
ENST00000573026ENST00000412517YWHAEchr171303340-SLC43A2chr171496573-0.042249760.95775026
ENST00000575977ENST00000301335YWHAEchr171303340-SLC43A2chr171496573-0.0283152760.97168475
ENST00000575977ENST00000571650YWHAEchr171303340-SLC43A2chr171496573-0.03783810.96216184
ENST00000575977ENST00000382147YWHAEchr171303340-SLC43A2chr171496573-0.0448513250.9551487
ENST00000575977ENST00000412517YWHAEchr171303340-SLC43A2chr171496573-0.0410899220.9589101
ENST00000264335ENST00000301335YWHAEchr171257505-SLC43A2chr171489345-0.0031574590.9968425
ENST00000264335ENST00000571650YWHAEchr171257505-SLC43A2chr171489345-0.0042988450.99570113
ENST00000264335ENST00000382147YWHAEchr171257505-SLC43A2chr171489345-0.0016845590.99831545
ENST00000264335ENST00000412517YWHAEchr171257505-SLC43A2chr171489345-0.00368840.9963116
ENST00000264335ENST00000301335YWHAEchr171303341-SLC43A2chr171496573-0.0290818810.97091806
ENST00000264335ENST00000571650YWHAEchr171303341-SLC43A2chr171496573-0.039046180.96095383
ENST00000264335ENST00000382147YWHAEchr171303341-SLC43A2chr171496573-0.0455442440.9544558
ENST00000264335ENST00000412517YWHAEchr171303341-SLC43A2chr171496573-0.041616740.95838326
ENST00000573026ENST00000301335YWHAEchr171303341-SLC43A2chr171496573-0.027945280.9720548
ENST00000573026ENST00000571650YWHAEchr171303341-SLC43A2chr171496573-0.037969880.9620301
ENST00000573026ENST00000382147YWHAEchr171303341-SLC43A2chr171496573-0.044842010.955158
ENST00000573026ENST00000412517YWHAEchr171303341-SLC43A2chr171496573-0.042249760.95775026
ENST00000575977ENST00000301335YWHAEchr171303341-SLC43A2chr171496573-0.0283152760.97168475
ENST00000575977ENST00000571650YWHAEchr171303341-SLC43A2chr171496573-0.03783810.96216184
ENST00000575977ENST00000382147YWHAEchr171303341-SLC43A2chr171496573-0.0448513250.9551487
ENST00000575977ENST00000412517YWHAEchr171303341-SLC43A2chr171496573-0.0410899220.9589101

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for YWHAE-SLC43A2

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
YWHAEchr171257504SLC43A2chr171489345983260DNLTLWTSDMQGDVGLYTSIFGVLQL
YWHAEchr171257505SLC43A2chr171489345983260DNLTLWTSDMQGDVGLYTSIFGVLQL

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Potential FusionNeoAntigen Information of YWHAE-SLC43A2 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
YWHAE-SLC43A2_1257504_1489345.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
YWHAE-SLC43A2chr171257504chr171489345983HLA-B15:02DMQGDVGLY0.67890.9618817
YWHAE-SLC43A2chr171257504chr171489345983HLA-B15:31DMQGDVGLY0.71190.9449817
YWHAE-SLC43A2chr171257504chr171489345983HLA-B15:21DMQGDVGLY0.68590.9333817
YWHAE-SLC43A2chr171257504chr171489345983HLA-B39:08SDMQGDVGL0.39750.9532716
YWHAE-SLC43A2chr171257504chr171489345983HLA-C05:09TSDMQGDVGL0.99980.9475616
YWHAE-SLC43A2chr171257504chr171489345983HLA-C08:15TSDMQGDVGL0.99940.9786616
YWHAE-SLC43A2chr171257504chr171489345983HLA-B35:28MQGDVGLY0.95120.9801917
YWHAE-SLC43A2chr171257504chr171489345983HLA-B18:04MQGDVGLY0.85160.9598917
YWHAE-SLC43A2chr171257504chr171489345983HLA-A25:01DVGLYTSIF0.99340.75641221
YWHAE-SLC43A2chr171257504chr171489345983HLA-B35:20DMQGDVGLY0.68340.9723817
YWHAE-SLC43A2chr171257504chr171489345983HLA-C05:01TSDMQGDVGL0.99980.9475616
YWHAE-SLC43A2chr171257504chr171489345983HLA-C08:02TSDMQGDVGL0.99940.9786616

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Potential FusionNeoAntigen Information of YWHAE-SLC43A2 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of YWHAE-SLC43A2

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
9634TSDMQGDVGLYTSIYWHAESLC43A2chr171257504chr171489345983

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of YWHAE-SLC43A2

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN9634TSDMQGDVGLYTSI-7.15543-7.26883
HLA-B14:023BVN9634TSDMQGDVGLYTSI-4.77435-5.80965
HLA-B52:013W399634TSDMQGDVGLYTSI-6.80875-6.92215
HLA-B52:013W399634TSDMQGDVGLYTSI-4.20386-5.23916
HLA-A11:014UQ29634TSDMQGDVGLYTSI-7.5194-8.5547
HLA-A11:014UQ29634TSDMQGDVGLYTSI-6.9601-7.0735
HLA-A24:025HGA9634TSDMQGDVGLYTSI-7.52403-7.63743
HLA-A24:025HGA9634TSDMQGDVGLYTSI-5.82433-6.85963
HLA-B27:056PYJ9634TSDMQGDVGLYTSI-3.28285-4.31815
HLA-B44:053DX89634TSDMQGDVGLYTSI-5.91172-6.94702
HLA-B44:053DX89634TSDMQGDVGLYTSI-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of YWHAE-SLC43A2

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
YWHAE-SLC43A2chr171257504chr1714893451221DVGLYTSIFACGTTGGCCTCTACACCTCCATCTTCG
YWHAE-SLC43A2chr171257504chr171489345616TSDMQGDVGLCTTCAGACATGCAGGGTGACGTTGGCCTCT
YWHAE-SLC43A2chr171257504chr171489345716SDMQGDVGLCAGACATGCAGGGTGACGTTGGCCTCT
YWHAE-SLC43A2chr171257504chr171489345817DMQGDVGLYACATGCAGGGTGACGTTGGCCTCTACA
YWHAE-SLC43A2chr171257504chr171489345917MQGDVGLYTGCAGGGTGACGTTGGCCTCTACA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of YWHAE-SLC43A2

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
LUADYWHAE-SLC43A2chr171257504ENST00000264335chr171489345ENST00000301335TCGA-55-8094

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Potential target of CAR-T therapy development for YWHAE-SLC43A2

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814365_3850570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814435_4550570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814462_4820570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814490_5100570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814516_5360570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915365_3850574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915435_4550574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915462_4820574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915490_5100574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915516_5360574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814365_3850570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814435_4550570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814462_4820570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814490_5100570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814516_5360570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915365_3850574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915435_4550574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915462_4820574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915490_5100574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915516_5360574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414177_1970570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414203_2230570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414323_3450570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414365_3850570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414435_4550570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414462_4820570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414490_5100570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414516_5360570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415177_1970574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415203_2230574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415323_3450574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415365_3850574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415435_4550574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415462_4820574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415490_5100574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415516_5360574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414177_1970570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414203_2230570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414323_3450570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414365_3850570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414435_4550570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414462_4820570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414490_5100570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414516_5360570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415177_1970574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415203_2230574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415323_3450574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415365_3850574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415435_4550574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415462_4820574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415490_5100574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415516_5360574.0TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to YWHAE-SLC43A2

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to YWHAE-SLC43A2

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneYWHAEC0036341Schizophrenia4PSYGENET
HgeneYWHAEC0005586Bipolar Disorder2PSYGENET
HgeneYWHAEC0206630Endometrial Stromal Sarcoma2ORPHANET
HgeneYWHAEC0027627Neoplasm Metastasis1CTD_human
HgeneYWHAEC0265219Miller Dieker syndrome1ORPHANET
HgeneYWHAEC0334488Clear cell sarcoma of kidney1ORPHANET
HgeneYWHAEC2750748Chromosome 17p13.3 Duplication Syndrome1ORPHANET
HgeneYWHAEC4707092Distal 17p13.3 microdeletion syndrome1ORPHANET