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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:ZFP30-C19orf33

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZFP30-C19orf33
FusionPDB ID: 101027
FusionGDB2.0 ID: 101027
HgeneTgene
Gene symbol

ZFP30

C19orf33

Gene ID

22835

64073

Gene nameZFP30 zinc finger proteinchromosome 19 open reading frame 33
SynonymsZNF745H2RSP|IMUP|IMUP-1|IMUP-2
Cytomap

19q13.12

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 30 homologzinc finger protein 745immortalization up-regulated proteinHAI-2 related small proteinhepatocyte growth factor activator inhibitor type 2-related small proteinimmortalization-upregulated protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000392144, ENST00000589018, 
ENST00000351218, ENST00000514101, 
ENST00000586732, 		ENST00000301246, 
ENST00000588605, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 8 X 5=2801 X 2 X 1=2
# samples 82
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Fusion gene context

PubMed: ZFP30 [Title/Abstract] AND C19orf33 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: ZFP30 [Title/Abstract] AND C19orf33 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZFP30(38134166)-C19orf33(38795015), # samples:3
Anticipated loss of major functional domain due to fusion event.ZFP30-C19orf33 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZFP30-C19orf33 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZFP30-C19orf33 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZFP30-C19orf33 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZFP30-C19orf33 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZFP30-C19orf33 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:38134166/chr19:38795015)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across ZFP30 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C19orf33 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000351218ZFP30chr1938134166-ENST00000301246C19orf33chr1938795015+11377935311091186
ENST00000351218ZFP30chr1938134166-ENST00000588605C19orf33chr1938795015+11937935311028165
ENST00000514101ZFP30chr1938134166-ENST00000301246C19orf33chr1938795015+966622360920186
ENST00000514101ZFP30chr1938134166-ENST00000588605C19orf33chr1938795015+1022622360857165
ENST00000351218ZFP30chr1938134165-ENST00000301246C19orf33chr1938795014+11377935311091186
ENST00000351218ZFP30chr1938134165-ENST00000588605C19orf33chr1938795014+11937935311028165
ENST00000514101ZFP30chr1938134165-ENST00000301246C19orf33chr1938795014+966622360920186
ENST00000514101ZFP30chr1938134165-ENST00000588605C19orf33chr1938795014+1022622360857165

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000351218ENST00000301246ZFP30chr1938134166-C19orf33chr1938795015+0.0085291240.9914709
ENST00000351218ENST00000588605ZFP30chr1938134166-C19orf33chr1938795015+0.063905450.9360945
ENST00000514101ENST00000301246ZFP30chr1938134166-C19orf33chr1938795015+0.0065105340.9934895
ENST00000514101ENST00000588605ZFP30chr1938134166-C19orf33chr1938795015+0.037382610.9626174
ENST00000351218ENST00000301246ZFP30chr1938134165-C19orf33chr1938795014+0.0085291240.9914709
ENST00000351218ENST00000588605ZFP30chr1938134165-C19orf33chr1938795014+0.063905450.9360945
ENST00000514101ENST00000301246ZFP30chr1938134165-C19orf33chr1938795014+0.0065105340.9934895
ENST00000514101ENST00000588605ZFP30chr1938134165-C19orf33chr1938795014+0.037382610.9626174

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ZFP30-C19orf33

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
ZFP30chr1938134165C19orf33chr193879501462213MTSSSSSKIMARDLVMFRDVAVDFSQ
ZFP30chr1938134165C19orf33chr193879501479313MTSSSSSKIMARDLVMFRDVAVDFSQ
ZFP30chr1938134166C19orf33chr193879501562213MTSSSSSKIMARDLVMFRDVAVDFSQ
ZFP30chr1938134166C19orf33chr193879501579313MTSSSSSKIMARDLVMFRDVAVDFSQ

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Potential FusionNeoAntigen Information of ZFP30-C19orf33 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ZFP30-C19orf33_38134165_38795014.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:01IMARDLVMF0.99520.9055817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:25IMARDLVMF0.98020.9153817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A74:09MARDLVMFR0.95740.5681918
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A74:11MARDLVMFR0.95740.5681918
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A74:03MARDLVMFR0.95740.5681918
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A31:02MARDLVMFR0.92430.5103918
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A32:13IMARDLVMF0.84960.9118817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A74:03IMARDLVMFR0.97840.6519818
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A74:09IMARDLVMFR0.97840.6519818
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A74:11IMARDLVMFR0.97840.6519818
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A31:02IMARDLVMFR0.96010.6064818
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A74:09KIMARDLVMFR0.99440.5415718
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A74:03KIMARDLVMFR0.99440.5415718
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A74:11KIMARDLVMFR0.99440.5415718
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A31:02KIMARDLVMFR0.960.5136718
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:07IMARDLVMF0.99550.7579817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:05IMARDLVMF0.87960.8804817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A31:01IMARDLVMFR0.98260.5698818
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:27IMARDLVMF0.99550.9139817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:135IMARDLVMF0.99520.907817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:125IMARDLVMF0.99520.9055817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:34IMARDLVMF0.99520.9055817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:33IMARDLVMF0.99520.9055817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:50IMARDLVMF0.99410.9276817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:24IMARDLVMF0.99310.8801817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:12IMARDLVMF0.99120.8215817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:39IMARDLVMF0.97810.8442817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A74:01MARDLVMFR0.95740.5681918
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:20IMARDLVMF0.87860.9233817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B35:28IMARDLVMF0.83030.9224817
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:73KIMARDLVM0.78750.7149716
ZFP30-C19orf33chr1938134165chr1938795014793HLA-B15:30KIMARDLVM0.71420.6872716
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A32:01KIMARDLVMF0.99680.9191717
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A74:01IMARDLVMFR0.97840.6519818
ZFP30-C19orf33chr1938134165chr1938795014793HLA-A74:01KIMARDLVMFR0.99440.5415718

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Potential FusionNeoAntigen Information of ZFP30-C19orf33 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ZFP30-C19orf33_38134165_38795014.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1457ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1501ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1501MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1501IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1501RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1502ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1502MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1503ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1503MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1504ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1504MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1504IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1505ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1505MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1505IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1505RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1506ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1506MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1506IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1506RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1507ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1507MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1507IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1507RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1508ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1508MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1509ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1509MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1509IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1509RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1510ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1510MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1511ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1511MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1512ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1512MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1512IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1512RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1513ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1513MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1513IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1513RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1514ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1514MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1515ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1516ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1516MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1516IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1516RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1518ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1518MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1518IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1518RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1519ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1519MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1520ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1520MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1520IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1520RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1521ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1521MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1521IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1521RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1522ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1522MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1522IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1522RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1523ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1523MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1524ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1524MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1524IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1524RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1525ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1526ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1526MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1527ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1528ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1528MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1528IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1528RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1529ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1529MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1529IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1530ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1530MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1531ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1531MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1532ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1532MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1532IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1532RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1533ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1533MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1533IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1533RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1534ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1535ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1535MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1535IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1535RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1536ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1536MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1536IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1536RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1537ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1537MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1537IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1537RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1538ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1538MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1539ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1539MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1540ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1540MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1540IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1540RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1541ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1541MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1541IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1541RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1542ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1542MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1542IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1542RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1543ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1543MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1543IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1543RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1544ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1544MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1545ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1545MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1545IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1545RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1546ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1546MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1546IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1546RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1547ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1547MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1548ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1548MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1548IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1548RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1549ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1549MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1549IMARDLVMFRDVAVD823
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1549RDLVMFRDVAVDFSQ1126
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1605ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1607ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1610ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1614ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1615ARDLVMFRDVAVDFS1025
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1615MARDLVMFRDVAVDF924
ZFP30-C19orf33chr1938134165chr1938795014793DRB1-1615IMARDLVMFRDVAVD823

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Fusion breakpoint peptide structures of ZFP30-C19orf33

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
8689SKIMARDLVMFRDVZFP30C19orf33chr1938134165chr1938795014793

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ZFP30-C19orf33

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN8689SKIMARDLVMFRDV-7.15543-7.26883
HLA-B14:023BVN8689SKIMARDLVMFRDV-4.77435-5.80965
HLA-B52:013W398689SKIMARDLVMFRDV-6.80875-6.92215
HLA-B52:013W398689SKIMARDLVMFRDV-4.20386-5.23916
HLA-A11:014UQ28689SKIMARDLVMFRDV-7.5194-8.5547
HLA-A11:014UQ28689SKIMARDLVMFRDV-6.9601-7.0735
HLA-A24:025HGA8689SKIMARDLVMFRDV-7.52403-7.63743
HLA-A24:025HGA8689SKIMARDLVMFRDV-5.82433-6.85963
HLA-B27:056PYJ8689SKIMARDLVMFRDV-3.28285-4.31815
HLA-B44:053DX88689SKIMARDLVMFRDV-5.91172-6.94702
HLA-B44:053DX88689SKIMARDLVMFRDV-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of ZFP30-C19orf33

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
ZFP30-C19orf33chr1938134165chr1938795014716KIMARDLVMAAAGAAGATGGACTCTAGCCCTGGAGC
ZFP30-C19orf33chr1938134165chr1938795014717KIMARDLVMFAAAGAAGATGGACTCTAGCCCTGGAGCCCA
ZFP30-C19orf33chr1938134165chr1938795014718KIMARDLVMFRAAAGAAGATGGACTCTAGCCCTGGAGCCCACCT
ZFP30-C19orf33chr1938134165chr1938795014817IMARDLVMFGAAGATGGACTCTAGCCCTGGAGCCCA
ZFP30-C19orf33chr1938134165chr1938795014818IMARDLVMFRGAAGATGGACTCTAGCCCTGGAGCCCACCT
ZFP30-C19orf33chr1938134165chr1938795014918MARDLVMFRGATGGACTCTAGCCCTGGAGCCCACCT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
ZFP30-C19orf33chr1938134165chr19387950141025ARDLVMFRDVAVDFSGGACTCTAGCCCTGGAGCCCACCTCCCAGAAGCCCGGTGTGGGGG
ZFP30-C19orf33chr1938134165chr19387950141126RDLVMFRDVAVDFSQCTCTAGCCCTGGAGCCCACCTCCCAGAAGCCCGGTGTGGGGGCGG
ZFP30-C19orf33chr1938134165chr1938795014823IMARDLVMFRDVAVDGAAGATGGACTCTAGCCCTGGAGCCCACCTCCCAGAAGCCCGGTG
ZFP30-C19orf33chr1938134165chr1938795014924MARDLVMFRDVAVDFGATGGACTCTAGCCCTGGAGCCCACCTCCCAGAAGCCCGGTGTGG

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Information of the samples that have these potential fusion neoantigens of ZFP30-C19orf33

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
UCECZFP30-C19orf33chr1938134165ENST00000351218chr1938795014ENST00000301246TCGA-AJ-A3BD

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Potential target of CAR-T therapy development for ZFP30-C19orf33

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to ZFP30-C19orf33

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZFP30-C19orf33

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource