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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:ZNF7-PPIE

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF7-PPIE
FusionPDB ID: 102982
FusionGDB2.0 ID: 102982
HgeneTgene
Gene symbol

ZNF7

PPIE

Gene ID

7553

10450

Gene namezinc finger protein 7peptidylprolyl isomerase E
SynonymsHF.16|KOX4|zf30CYP-33|CYP33
Cytomap

8q24.3

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 7C2-H2 type zinc finger proteinZinc finger protein-7 (KOX4)zinc finger protein 7 (KOX 4, clone HF.16)zinc finger protein HF.16zinc finger protein KOX4zinc finger protein zfp30peptidyl-prolyl cis-trans isomerase EPPIase Ecyclophilin-33peptidylprolyl isomerase E (cyclophilin E)rotamase E
Modification date2020031320200313
UniProtAcc

Q9H7S9

Main function of 5'-partner protein: FUNCTION: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}.		.
Ensembl transtripts involved in fusion geneENST idsENST00000532393, ENST00000325217, 
ENST00000325241, ENST00000446747, 
ENST00000525266, ENST00000528130, 
ENST00000528372, ENST00000529819, 
ENST00000544249, 		ENST00000324379, 
ENST00000356511, ENST00000372830, 
ENST00000470213, ENST00000480169, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 2 X 3=308 X 9 X 3=216
# samples 610
** MAII scorelog2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/216*10)=-1.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: ZNF7 [Title/Abstract] AND PPIE [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: ZNF7 [Title/Abstract] AND PPIE [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF7(146062892)-PPIE(40205837), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF7-PPIE seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF7-PPIE seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF7-PPIE seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF7-PPIE seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPIE

GO:0000398

mRNA splicing, via spliceosome

28076346

TgenePPIE

GO:0000413

protein peptidyl-prolyl isomerization

20676357



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:146062892/chr1:40205837)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across ZNF7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPIE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000325241ZNF7chr8146062892+ENST00000324379PPIEchr140205837+16113841281258376
ENST00000325241ZNF7chr8146062892+ENST00000356511PPIEchr140205837+14163841281243371
ENST00000325241ZNF7chr8146062892+ENST00000470213PPIEchr140205837+1280384128979283
ENST00000325241ZNF7chr8146062892+ENST00000372830PPIEchr140205837+15513841281297389
ENST00000446747ZNF7chr8146062892+ENST00000324379PPIEchr140205837+1603376871250387
ENST00000446747ZNF7chr8146062892+ENST00000356511PPIEchr140205837+1408376871235382
ENST00000446747ZNF7chr8146062892+ENST00000470213PPIEchr140205837+127237687971294
ENST00000446747ZNF7chr8146062892+ENST00000372830PPIEchr140205837+1543376871289400
ENST00000525266ZNF7chr8146062892+ENST00000324379PPIEchr140205837+1570343871217376
ENST00000525266ZNF7chr8146062892+ENST00000356511PPIEchr140205837+1375343871202371
ENST00000525266ZNF7chr8146062892+ENST00000470213PPIEchr140205837+123934387938283
ENST00000525266ZNF7chr8146062892+ENST00000372830PPIEchr140205837+1510343871256389
ENST00000325217ZNF7chr8146062892+ENST00000324379PPIEchr140205837+1602375861249387
ENST00000325217ZNF7chr8146062892+ENST00000356511PPIEchr140205837+1407375861234382
ENST00000325217ZNF7chr8146062892+ENST00000470213PPIEchr140205837+127137586970294
ENST00000325217ZNF7chr8146062892+ENST00000372830PPIEchr140205837+1542375861288400
ENST00000529819ZNF7chr8146062892+ENST00000324379PPIEchr140205837+159236511239412
ENST00000529819ZNF7chr8146062892+ENST00000356511PPIEchr140205837+139736511224407
ENST00000529819ZNF7chr8146062892+ENST00000470213PPIEchr140205837+12613651960319
ENST00000529819ZNF7chr8146062892+ENST00000372830PPIEchr140205837+153236511278425
ENST00000528372ZNF7chr8146062892+ENST00000324379PPIEchr140205837+17144871261361411
ENST00000528372ZNF7chr8146062892+ENST00000356511PPIEchr140205837+15194871261346406
ENST00000528372ZNF7chr8146062892+ENST00000470213PPIEchr140205837+13834871261082318
ENST00000528372ZNF7chr8146062892+ENST00000372830PPIEchr140205837+16544871261400424
ENST00000528130ZNF7chr8146062892+ENST00000324379PPIEchr140205837+1520293371167376
ENST00000528130ZNF7chr8146062892+ENST00000356511PPIEchr140205837+1325293371152371
ENST00000528130ZNF7chr8146062892+ENST00000470213PPIEchr140205837+118929337888283
ENST00000528130ZNF7chr8146062892+ENST00000372830PPIEchr140205837+1460293371206389
ENST00000325241ZNF7chr8146062892+ENST00000324379PPIEchr140205836+16113841281258376
ENST00000325241ZNF7chr8146062892+ENST00000356511PPIEchr140205836+14163841281243371
ENST00000325241ZNF7chr8146062892+ENST00000470213PPIEchr140205836+1280384128979283
ENST00000325241ZNF7chr8146062892+ENST00000372830PPIEchr140205836+15513841281297389
ENST00000446747ZNF7chr8146062892+ENST00000324379PPIEchr140205836+1603376871250387
ENST00000446747ZNF7chr8146062892+ENST00000356511PPIEchr140205836+1408376871235382
ENST00000446747ZNF7chr8146062892+ENST00000470213PPIEchr140205836+127237687971294
ENST00000446747ZNF7chr8146062892+ENST00000372830PPIEchr140205836+1543376871289400
ENST00000525266ZNF7chr8146062892+ENST00000324379PPIEchr140205836+1570343871217376
ENST00000525266ZNF7chr8146062892+ENST00000356511PPIEchr140205836+1375343871202371
ENST00000525266ZNF7chr8146062892+ENST00000470213PPIEchr140205836+123934387938283
ENST00000525266ZNF7chr8146062892+ENST00000372830PPIEchr140205836+1510343871256389
ENST00000325217ZNF7chr8146062892+ENST00000324379PPIEchr140205836+1602375861249387
ENST00000325217ZNF7chr8146062892+ENST00000356511PPIEchr140205836+1407375861234382
ENST00000325217ZNF7chr8146062892+ENST00000470213PPIEchr140205836+127137586970294
ENST00000325217ZNF7chr8146062892+ENST00000372830PPIEchr140205836+1542375861288400
ENST00000529819ZNF7chr8146062892+ENST00000324379PPIEchr140205836+159236511239412
ENST00000529819ZNF7chr8146062892+ENST00000356511PPIEchr140205836+139736511224407
ENST00000529819ZNF7chr8146062892+ENST00000470213PPIEchr140205836+12613651960319
ENST00000529819ZNF7chr8146062892+ENST00000372830PPIEchr140205836+153236511278425
ENST00000528372ZNF7chr8146062892+ENST00000324379PPIEchr140205836+17144871261361411
ENST00000528372ZNF7chr8146062892+ENST00000356511PPIEchr140205836+15194871261346406
ENST00000528372ZNF7chr8146062892+ENST00000470213PPIEchr140205836+13834871261082318
ENST00000528372ZNF7chr8146062892+ENST00000372830PPIEchr140205836+16544871261400424
ENST00000528130ZNF7chr8146062892+ENST00000324379PPIEchr140205836+1520293371167376
ENST00000528130ZNF7chr8146062892+ENST00000356511PPIEchr140205836+1325293371152371
ENST00000528130ZNF7chr8146062892+ENST00000470213PPIEchr140205836+118929337888283
ENST00000528130ZNF7chr8146062892+ENST00000372830PPIEchr140205836+1460293371206389

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000325241ENST00000324379ZNF7chr8146062892+PPIEchr140205837+0.0020820550.99791795
ENST00000325241ENST00000356511ZNF7chr8146062892+PPIEchr140205837+0.0012121520.9987878
ENST00000325241ENST00000470213ZNF7chr8146062892+PPIEchr140205837+0.0015216060.99847835
ENST00000325241ENST00000372830ZNF7chr8146062892+PPIEchr140205837+0.0013980760.998602
ENST00000446747ENST00000324379ZNF7chr8146062892+PPIEchr140205837+0.0033151640.99668485
ENST00000446747ENST00000356511ZNF7chr8146062892+PPIEchr140205837+0.002050290.9979498
ENST00000446747ENST00000470213ZNF7chr8146062892+PPIEchr140205837+0.0029884970.99701154
ENST00000446747ENST00000372830ZNF7chr8146062892+PPIEchr140205837+0.0019605110.99803954
ENST00000525266ENST00000324379ZNF7chr8146062892+PPIEchr140205837+0.0022451590.9977549
ENST00000525266ENST00000356511ZNF7chr8146062892+PPIEchr140205837+0.0012717650.9987282
ENST00000525266ENST00000470213ZNF7chr8146062892+PPIEchr140205837+0.0016299830.99837
ENST00000525266ENST00000372830ZNF7chr8146062892+PPIEchr140205837+0.0014630330.99853694
ENST00000325217ENST00000324379ZNF7chr8146062892+PPIEchr140205837+0.0033221930.9966779
ENST00000325217ENST00000356511ZNF7chr8146062892+PPIEchr140205837+0.0020604120.9979395
ENST00000325217ENST00000470213ZNF7chr8146062892+PPIEchr140205837+0.0030344890.99696547
ENST00000325217ENST00000372830ZNF7chr8146062892+PPIEchr140205837+0.0019717140.9980282
ENST00000529819ENST00000324379ZNF7chr8146062892+PPIEchr140205837+0.0035702650.99642974
ENST00000529819ENST00000356511ZNF7chr8146062892+PPIEchr140205837+0.0020229420.9979771
ENST00000529819ENST00000470213ZNF7chr8146062892+PPIEchr140205837+0.0016692950.9983308
ENST00000529819ENST00000372830ZNF7chr8146062892+PPIEchr140205837+0.0022375330.99776244
ENST00000528372ENST00000324379ZNF7chr8146062892+PPIEchr140205837+0.0019558720.99804413
ENST00000528372ENST00000356511ZNF7chr8146062892+PPIEchr140205837+0.0012442290.9987558
ENST00000528372ENST00000470213ZNF7chr8146062892+PPIEchr140205837+0.0014625170.99853754
ENST00000528372ENST00000372830ZNF7chr8146062892+PPIEchr140205837+0.0014144070.9985856
ENST00000528130ENST00000324379ZNF7chr8146062892+PPIEchr140205837+0.0024033420.9975967
ENST00000528130ENST00000356511ZNF7chr8146062892+PPIEchr140205837+0.0012581540.9987419
ENST00000528130ENST00000470213ZNF7chr8146062892+PPIEchr140205837+0.001858050.998142
ENST00000528130ENST00000372830ZNF7chr8146062892+PPIEchr140205837+0.0014631870.9985368
ENST00000325241ENST00000324379ZNF7chr8146062892+PPIEchr140205836+0.0020820550.99791795
ENST00000325241ENST00000356511ZNF7chr8146062892+PPIEchr140205836+0.0012121520.9987878
ENST00000325241ENST00000470213ZNF7chr8146062892+PPIEchr140205836+0.0015216060.99847835
ENST00000325241ENST00000372830ZNF7chr8146062892+PPIEchr140205836+0.0013980760.998602
ENST00000446747ENST00000324379ZNF7chr8146062892+PPIEchr140205836+0.0033151640.99668485
ENST00000446747ENST00000356511ZNF7chr8146062892+PPIEchr140205836+0.002050290.9979498
ENST00000446747ENST00000470213ZNF7chr8146062892+PPIEchr140205836+0.0029884970.99701154
ENST00000446747ENST00000372830ZNF7chr8146062892+PPIEchr140205836+0.0019605110.99803954
ENST00000525266ENST00000324379ZNF7chr8146062892+PPIEchr140205836+0.0022451590.9977549
ENST00000525266ENST00000356511ZNF7chr8146062892+PPIEchr140205836+0.0012717650.9987282
ENST00000525266ENST00000470213ZNF7chr8146062892+PPIEchr140205836+0.0016299830.99837
ENST00000525266ENST00000372830ZNF7chr8146062892+PPIEchr140205836+0.0014630330.99853694
ENST00000325217ENST00000324379ZNF7chr8146062892+PPIEchr140205836+0.0033221930.9966779
ENST00000325217ENST00000356511ZNF7chr8146062892+PPIEchr140205836+0.0020604120.9979395
ENST00000325217ENST00000470213ZNF7chr8146062892+PPIEchr140205836+0.0030344890.99696547
ENST00000325217ENST00000372830ZNF7chr8146062892+PPIEchr140205836+0.0019717140.9980282
ENST00000529819ENST00000324379ZNF7chr8146062892+PPIEchr140205836+0.0035702650.99642974
ENST00000529819ENST00000356511ZNF7chr8146062892+PPIEchr140205836+0.0020229420.9979771
ENST00000529819ENST00000470213ZNF7chr8146062892+PPIEchr140205836+0.0016692950.9983308
ENST00000529819ENST00000372830ZNF7chr8146062892+PPIEchr140205836+0.0022375330.99776244
ENST00000528372ENST00000324379ZNF7chr8146062892+PPIEchr140205836+0.0019558720.99804413
ENST00000528372ENST00000356511ZNF7chr8146062892+PPIEchr140205836+0.0012442290.9987558
ENST00000528372ENST00000470213ZNF7chr8146062892+PPIEchr140205836+0.0014625170.99853754
ENST00000528372ENST00000372830ZNF7chr8146062892+PPIEchr140205836+0.0014144070.9985856
ENST00000528130ENST00000324379ZNF7chr8146062892+PPIEchr140205836+0.0024033420.9975967
ENST00000528130ENST00000356511ZNF7chr8146062892+PPIEchr140205836+0.0012581540.9987419
ENST00000528130ENST00000470213ZNF7chr8146062892+PPIEchr140205836+0.001858050.998142
ENST00000528130ENST00000372830ZNF7chr8146062892+PPIEchr140205836+0.0014631870.9985368

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ZNF7-PPIE

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
ZNF7chr8146062892PPIEchr14020583629385GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr14020583634385GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr140205836365121GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr14020583637596GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr14020583637696GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr14020583638485GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr140205836487120GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr14020583729385GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr14020583734385GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr140205837365121GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr14020583737596GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr14020583737696GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr14020583738485GAEGTEAPRTSKTGGLAEEVDDKVLH
ZNF7chr8146062892PPIEchr140205837487120GAEGTEAPRTSKTGGLAEEVDDKVLH

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Potential FusionNeoAntigen Information of ZNF7-PPIE in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ZNF7-PPIE_146062892_40205836.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ZNF7-PPIEchr8146062892chr140205836375HLA-B07:05APRTSKTGGL0.99940.5457616
ZNF7-PPIEchr8146062892chr140205836375HLA-B07:02APRTSKTGGL0.99930.5179616
ZNF7-PPIEchr8146062892chr140205836375HLA-B07:12APRTSKTGGL0.99540.6078616
ZNF7-PPIEchr8146062892chr140205836375HLA-B42:02APRTSKTGGL0.83960.5409616
ZNF7-PPIEchr8146062892chr140205836375HLA-B42:01APRTSKTGGL0.81390.5323616
ZNF7-PPIEchr8146062892chr140205836375HLA-B07:22APRTSKTGGL0.99930.5179616

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Potential FusionNeoAntigen Information of ZNF7-PPIE in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of ZNF7-PPIE

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
500APRTSKTGGLAEEVZNF7PPIEchr8146062892chr140205836375

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ZNF7-PPIE

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN500APRTSKTGGLAEEV-7.17232-7.28572
HLA-B14:023BVN500APRTSKTGGLAEEV-4.95948-5.99478
HLA-B52:013W39500APRTSKTGGLAEEV-6.80683-6.92023
HLA-B52:013W39500APRTSKTGGLAEEV-3.90062-4.93592
HLA-A11:014UQ2500APRTSKTGGLAEEV1000110000
HLA-A24:025HGA500APRTSKTGGLAEEV-8.77961-8.89301
HLA-A24:025HGA500APRTSKTGGLAEEV-5.66496-6.70026
HLA-B44:053DX8500APRTSKTGGLAEEV-5.65551-5.76891
HLA-B44:053DX8500APRTSKTGGLAEEV-3.88952-4.92482
HLA-A02:016TDR500APRTSKTGGLAEEV-4.65662-5.69192

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Vaccine Design for the FusionNeoAntigens of ZNF7-PPIE

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
ZNF7-PPIEchr8146062892chr140205836616APRTSKTGGLCACCAAGGACCTCCAAGACAGGTGGACTGG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of ZNF7-PPIE

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
OVZNF7-PPIEchr8146062892ENST00000325217chr140205836ENST00000324379TCGA-25-1633

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Potential target of CAR-T therapy development for ZNF7-PPIE

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to ZNF7-PPIE

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZNF7-PPIE

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource