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Fusion Protein:CAMSAP1-KCNT1

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CAMSAP1-KCNT1
	FusionPDB ID: 12725
	FusionGDB2.0 ID: 12725
		Hgene	Tgene
	Gene symbol	CAMSAP1	KCNT1
	Gene ID	157922	57582
	Gene name	calmodulin regulated spectrin associated protein 1	potassium sodium-activated channel subfamily T member 1
	Synonyms	-	EIEE14\|ENFL5\|KCa4.1\|SLACK\|Slo2.2\|bA100C15.2
	Cytomap	9q34.3	9q34.3
	Type of gene	protein-coding	protein-coding
	Description	calmodulin-regulated spectrin-associated protein 1epididymis secretory sperm binding protein	potassium channel subfamily T member 1Sequence like a calcium-activated K+ channelpotassium channel, sodium activated subfamily T, member 1potassium channel, subfamily T, member 1
	Modification date	20200313	20200313
	UniProtAcc	Q5T5Y3 Main function of 5'-partner protein: FUNCTION: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24486153, PubMed:24706919, PubMed:24117850). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269\|PubMed:19508979, ECO:0000269\|PubMed:21834987, ECO:0000269\|PubMed:24117850, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:24706919}.	Q5JUK3 Main function of 5'-partner protein: FUNCTION: Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). {ECO:0000250}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000312405, ENST00000389532, ENST00000409386, ENST00000483991,	ENST00000263604, ENST00000298480, ENST00000371757, ENST00000486577, ENST00000487664, ENST00000488444, ENST00000490355, ENST00000491806,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	11 X 10 X 7=770	2 X 4 X 2=16
	# samples	13	4
	** MAII score	log2(13/770*10)=-2.56634682255381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Fusion gene context	PubMed: CAMSAP1 [Title/Abstract] AND KCNT1 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: CAMSAP1 [Title/Abstract] AND KCNT1 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CAMSAP1(138758302)-KCNT1(138656877), # samples:3
Anticipated loss of major functional domain due to fusion event.	CAMSAP1-KCNT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CAMSAP1-KCNT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CAMSAP1-KCNT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CAMSAP1-KCNT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CAMSAP1	GO:0000226	microtubule cytoskeleton organization	24486153\|24706919
Hgene	CAMSAP1	GO:0031113	regulation of microtubule polymerization	24486153\|24706919

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:138758302/chr9:138656877)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across CAMSAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KCNT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000389532	CAMSAP1	chr9	138758302	-	ENST00000298480	KCNT1	chr9	138656877	+	4452	731	59	3466	1135
ENST00000389532	CAMSAP1	chr9	138758302	-	ENST00000487664	KCNT1	chr9	138656877	+	4452	731	59	3466	1135
ENST00000389532	CAMSAP1	chr9	138758302	-	ENST00000371757	KCNT1	chr9	138656877	+	4346	731	59	3403	1114
ENST00000389532	CAMSAP1	chr9	138758302	-	ENST00000486577	KCNT1	chr9	138656877	+	3455	731	59	3454	1132
ENST00000389532	CAMSAP1	chr9	138758302	-	ENST00000491806	KCNT1	chr9	138656877	+	3464	731	59	3460	1133
ENST00000389532	CAMSAP1	chr9	138758302	-	ENST00000488444	KCNT1	chr9	138656877	+	3464	731	59	3460	1133
ENST00000389532	CAMSAP1	chr9	138758302	-	ENST00000490355	KCNT1	chr9	138656877	+	3461	731	59	3457	1132
ENST00000389532	CAMSAP1	chr9	138758302	-	ENST00000263604	KCNT1	chr9	138656877	+	4431	731	59	3445	1128
ENST00000409386	CAMSAP1	chr9	138758302	-	ENST00000298480	KCNT1	chr9	138656877	+	4456	735	63	3470	1135
ENST00000409386	CAMSAP1	chr9	138758302	-	ENST00000487664	KCNT1	chr9	138656877	+	4456	735	63	3470	1135
ENST00000409386	CAMSAP1	chr9	138758302	-	ENST00000371757	KCNT1	chr9	138656877	+	4350	735	63	3407	1114
ENST00000409386	CAMSAP1	chr9	138758302	-	ENST00000486577	KCNT1	chr9	138656877	+	3459	735	63	3458	1131
ENST00000409386	CAMSAP1	chr9	138758302	-	ENST00000491806	KCNT1	chr9	138656877	+	3468	735	63	3464	1133
ENST00000409386	CAMSAP1	chr9	138758302	-	ENST00000488444	KCNT1	chr9	138656877	+	3468	735	63	3464	1133
ENST00000409386	CAMSAP1	chr9	138758302	-	ENST00000490355	KCNT1	chr9	138656877	+	3465	735	63	3461	1132
ENST00000409386	CAMSAP1	chr9	138758302	-	ENST00000263604	KCNT1	chr9	138656877	+	4435	735	63	3449	1128
ENST00000389532	CAMSAP1	chr9	138758301	-	ENST00000298480	KCNT1	chr9	138656876	+	4452	731	59	3466	1135
ENST00000389532	CAMSAP1	chr9	138758301	-	ENST00000487664	KCNT1	chr9	138656876	+	4452	731	59	3466	1135
ENST00000389532	CAMSAP1	chr9	138758301	-	ENST00000371757	KCNT1	chr9	138656876	+	4346	731	59	3403	1114
ENST00000389532	CAMSAP1	chr9	138758301	-	ENST00000486577	KCNT1	chr9	138656876	+	3455	731	59	3454	1132
ENST00000389532	CAMSAP1	chr9	138758301	-	ENST00000491806	KCNT1	chr9	138656876	+	3464	731	59	3460	1133
ENST00000389532	CAMSAP1	chr9	138758301	-	ENST00000488444	KCNT1	chr9	138656876	+	3464	731	59	3460	1133
ENST00000389532	CAMSAP1	chr9	138758301	-	ENST00000490355	KCNT1	chr9	138656876	+	3461	731	59	3457	1132
ENST00000389532	CAMSAP1	chr9	138758301	-	ENST00000263604	KCNT1	chr9	138656876	+	4431	731	59	3445	1128
ENST00000409386	CAMSAP1	chr9	138758301	-	ENST00000298480	KCNT1	chr9	138656876	+	4456	735	63	3470	1135
ENST00000409386	CAMSAP1	chr9	138758301	-	ENST00000487664	KCNT1	chr9	138656876	+	4456	735	63	3470	1135
ENST00000409386	CAMSAP1	chr9	138758301	-	ENST00000371757	KCNT1	chr9	138656876	+	4350	735	63	3407	1114
ENST00000409386	CAMSAP1	chr9	138758301	-	ENST00000486577	KCNT1	chr9	138656876	+	3459	735	63	3458	1131
ENST00000409386	CAMSAP1	chr9	138758301	-	ENST00000491806	KCNT1	chr9	138656876	+	3468	735	63	3464	1133
ENST00000409386	CAMSAP1	chr9	138758301	-	ENST00000488444	KCNT1	chr9	138656876	+	3468	735	63	3464	1133
ENST00000409386	CAMSAP1	chr9	138758301	-	ENST00000490355	KCNT1	chr9	138656876	+	3465	735	63	3461	1132
ENST00000409386	CAMSAP1	chr9	138758301	-	ENST00000263604	KCNT1	chr9	138656876	+	4435	735	63	3449	1128

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000389532	ENST00000298480	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.003431378	0.99656856
ENST00000389532	ENST00000487664	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.003431378	0.99656856
ENST00000389532	ENST00000371757	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.004077303	0.9959227
ENST00000389532	ENST00000486577	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.005187507	0.9948125
ENST00000389532	ENST00000491806	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.004109445	0.9958905
ENST00000389532	ENST00000488444	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.004109445	0.9958905
ENST00000389532	ENST00000490355	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.003817752	0.99618226
ENST00000389532	ENST00000263604	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.003340513	0.9966595
ENST00000409386	ENST00000298480	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.003449548	0.99655044
ENST00000409386	ENST00000487664	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.003449548	0.99655044
ENST00000409386	ENST00000371757	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.004094726	0.9959053
ENST00000409386	ENST00000486577	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.005211773	0.99478817
ENST00000409386	ENST00000491806	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.00412873	0.99587125
ENST00000409386	ENST00000488444	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.00412873	0.99587125
ENST00000409386	ENST00000490355	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.003834283	0.99616575
ENST00000409386	ENST00000263604	CAMSAP1	chr9	138758302	-	KCNT1	chr9	138656877	+	0.003358708	0.9966413
ENST00000389532	ENST00000298480	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.003431378	0.99656856
ENST00000389532	ENST00000487664	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.003431378	0.99656856
ENST00000389532	ENST00000371757	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.004077303	0.9959227
ENST00000389532	ENST00000486577	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.005187507	0.9948125
ENST00000389532	ENST00000491806	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.004109445	0.9958905
ENST00000389532	ENST00000488444	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.004109445	0.9958905
ENST00000389532	ENST00000490355	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.003817752	0.99618226
ENST00000389532	ENST00000263604	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.003340513	0.9966595
ENST00000409386	ENST00000298480	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.003449548	0.99655044
ENST00000409386	ENST00000487664	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.003449548	0.99655044
ENST00000409386	ENST00000371757	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.004094726	0.9959053
ENST00000409386	ENST00000486577	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.005211773	0.99478817
ENST00000409386	ENST00000491806	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.00412873	0.99587125
ENST00000409386	ENST00000488444	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.00412873	0.99587125
ENST00000409386	ENST00000490355	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.003834283	0.99616575
ENST00000409386	ENST00000263604	CAMSAP1	chr9	138758301	-	KCNT1	chr9	138656876	+	0.003358708	0.9966413

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for CAMSAP1-KCNT1

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
CAMSAP1	chr9	138758301	KCNT1	chr9	138656876	731	224	LKQQLLESPAHQKFEELVYLWMERQK
CAMSAP1	chr9	138758301	KCNT1	chr9	138656876	735	224	LKQQLLESPAHQKFEELVYLWMERQK
CAMSAP1	chr9	138758302	KCNT1	chr9	138656877	731	224	LKQQLLESPAHQKFEELVYLWMERQK
CAMSAP1	chr9	138758302	KCNT1	chr9	138656877	735	224	LKQQLLESPAHQKFEELVYLWMERQK

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Potential FusionNeoAntigen Information of CAMSAP1-KCNT1 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

CAMSAP1-KCNT1_138758301_138656876.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:24	AHQKFEEL	0.9998	0.7713	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:01	AHQKFEEL	0.9997	0.963	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B38:02	AHQKFEEL	0.9996	0.9794	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B38:01	AHQKFEEL	0.9996	0.9809	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:10	AHQKFEEL	0.9983	0.5871	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:37	AHQKFEEL	0.9868	0.596	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:03	QKFEELVY	0.9528	0.7608	11	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:01	HQKFEELVY	0.9998	0.7833	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B44:03	LESPAHQKF	0.9987	0.7673	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:01	LESPAHQKF	0.9982	0.5982	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:01	QKFEELVYL	0.9969	0.8772	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:06	QKFEELVYL	0.9959	0.68	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B38:01	QKFEELVYL	0.9956	0.9344	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B38:02	QKFEELVYL	0.9947	0.9373	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B13:01	LESPAHQKF	0.9941	0.6441	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-A32:13	KFEELVYLW	0.9941	0.982	12	21
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B57:01	KFEELVYLW	0.9926	0.9923	12	21
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:25	HQKFEELVY	0.9925	0.8502	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:13	QKFEELVYL	0.9919	0.8976	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B38:01	AHQKFEELV	0.9845	0.9647	9	18
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B38:02	AHQKFEELV	0.9832	0.9567	9	18
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:02	HQKFEELVY	0.9718	0.8805	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B58:01	KFEELVYLW	0.9596	0.9805	12	21
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B14:01	QKFEELVYL	0.9494	0.6396	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B14:02	QKFEELVYL	0.9494	0.6396	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B58:02	KFEELVYLW	0.9451	0.9672	12	21
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B47:01	HQKFEELVY	0.8187	0.5104	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:10	QKFEELVYL	0.7596	0.5152	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B08:01	PAHQKFEEL	0.7476	0.8018	8	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:03	HQKFEELVY	0.6336	0.6741	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-A24:14	KFEELVYLW	0.6244	0.5193	12	21
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:01	HQKFEELVY	0.6153	0.9042	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:18	HQKFEELVY	0.5249	0.6262	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:03	QKFEELVYL	0.4936	0.6882	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B47:01	QKFEELVYL	0.2555	0.5057	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B52:01	QKFEELVYL	0.1354	0.8122	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:13	LESPAHQKF	0.0807	0.7447	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B07:02	SPAHQKFEEL	0.9983	0.522	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B48:01	HQKFEELVYL	0.9712	0.5107	10	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B44:03	LLESPAHQKF	0.9427	0.8087	4	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B08:01	SPAHQKFEEL	0.9221	0.7217	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:18	AHQKFEELVY	0.9091	0.6343	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:01	AHQKFEELVY	0.8856	0.7772	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:25	AHQKFEELVY	0.8744	0.8464	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:03	AHQKFEELVY	0.8644	0.6811	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B08:09	SPAHQKFEEL	0.8636	0.7906	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-A02:21	HQKFEELVYL	0.8348	0.5064	10	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B13:01	HQKFEELVYL	0.8344	0.8609	10	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B35:03	SPAHQKFEEL	0.7681	0.7004	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:01	LLESPAHQKF	0.64	0.5912	4	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B38:01	AHQKFEELVYL	0.999	0.9461	9	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B38:02	AHQKFEELVYL	0.9988	0.9463	9	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-A32:13	QLLESPAHQKF	0.9977	0.7891	3	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-A32:13	HQKFEELVYLW	0.9948	0.9606	10	21
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B44:03	QLLESPAHQKF	0.9773	0.7969	3	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C04:07	KFEELVYL	0.9999	0.9508	12	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C04:10	KFEELVYL	0.9999	0.9567	12	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:09	AHQKFEEL	0.9998	0.8705	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:12	AHQKFEEL	0.9996	0.9639	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:05	AHQKFEEL	0.9994	0.9565	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C04:14	KFEELVYL	0.9957	0.9605	12	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B14:03	AHQKFEEL	0.9503	0.9265	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:07	HQKFEELVY	0.9996	0.5989	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:09	QKFEELVYL	0.997	0.5545	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:12	QKFEELVYL	0.9967	0.8754	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C07:95	QKFEELVYL	0.9945	0.6677	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C07:29	QKFEELVYL	0.9932	0.8986	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:04	HQKFEELVY	0.9887	0.7702	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:05	QKFEELVYL	0.9881	0.8822	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C07:13	QKFEELVYL	0.9844	0.913	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:05	AHQKFEELV	0.9832	0.9071	9	18
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:21	HQKFEELVY	0.9637	0.8434	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:05	HQKFEELVY	0.8652	0.874	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:31	HQKFEELVY	0.7688	0.8851	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B51:07	LESPAHQKF	0.4084	0.6759	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:08	LESPAHQKF	0.3957	0.5448	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C12:16	QKFEELVYL	0.2148	0.9553	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B07:12	SPAHQKFEEL	0.9957	0.6983	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:04	HQKFEELVYL	0.9861	0.6979	10	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B42:02	SPAHQKFEEL	0.9445	0.708	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B42:01	SPAHQKFEEL	0.9426	0.7041	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:07	AHQKFEELVY	0.8977	0.6271	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:05	AHQKFEELVY	0.8376	0.8784	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:04	AHQKFEELVY	0.7916	0.7868	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:10	SPAHQKFEEL	0.656	0.8401	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:05	AHQKFEELVYL	0.9976	0.8849	9	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C04:01	KFEELVYL	0.9999	0.9508	12	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C18:01	KFEELVYL	0.9998	0.9513	12	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B38:05	AHQKFEEL	0.9996	0.9809	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C04:04	KFEELVYL	0.9967	0.9691	12	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:09	AHQKFEEL	0.9953	0.8104	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:11	AHQKFEEL	0.9859	0.9225	9	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:54	QKFEELVY	0.9199	0.7616	11	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B48:02	QKFEELVY	0.9155	0.9294	11	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:27	HQKFEELVY	0.9998	0.7999	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:50	HQKFEELVY	0.9998	0.8909	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:135	HQKFEELVY	0.9998	0.7834	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:33	HQKFEELVY	0.9998	0.7833	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:34	HQKFEELVY	0.9998	0.7833	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:125	HQKFEELVY	0.9998	0.7833	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:08	HQKFEELVY	0.9996	0.7159	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:11	HQKFEELVY	0.9996	0.7067	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B35:43	HQKFEELVY	0.9995	0.7137	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:35	HQKFEELVY	0.9995	0.7686	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:24	HQKFEELVY	0.9994	0.757	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B44:26	LESPAHQKF	0.9987	0.7673	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:07	LESPAHQKF	0.9987	0.5582	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B44:13	LESPAHQKF	0.9987	0.7673	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B44:07	LESPAHQKF	0.9987	0.7673	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:12	HQKFEELVY	0.9982	0.8134	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:05	LESPAHQKF	0.9982	0.5982	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:04	LESPAHQKF	0.9981	0.6207	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:08	LESPAHQKF	0.9979	0.551	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:06	LESPAHQKF	0.9977	0.5959	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:02	QKFEELVYL	0.9974	0.8896	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:31	QKFEELVYL	0.9966	0.875	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:03	LESPAHQKF	0.9964	0.5832	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B38:05	QKFEELVYL	0.9956	0.9344	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:39	HQKFEELVY	0.9933	0.7548	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:53	HQKFEELVY	0.9928	0.7461	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B57:10	KFEELVYLW	0.9926	0.9923	12	21
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-A32:01	KFEELVYLW	0.992	0.9852	12	21
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B38:05	AHQKFEELV	0.9845	0.9647	9	18
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:11	LESPAHQKF	0.9802	0.5675	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B27:09	QKFEELVYL	0.9752	0.7476	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C07:22	QKFEELVYL	0.9372	0.732	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B57:04	KFEELVYLW	0.9161	0.8727	12	21
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:53	LESPAHQKF	0.9032	0.6049	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:54	HQKFEELVY	0.8866	0.6997	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:20	HQKFEELVY	0.8529	0.9197	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:24	LESPAHQKF	0.849	0.6876	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:11	AHQKFEELV	0.8478	0.8717	9	18
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B35:28	LESPAHQKF	0.8331	0.5489	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C06:08	QKFEELVYL	0.8272	0.9813	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B35:28	HQKFEELVY	0.8119	0.9251	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B35:20	LESPAHQKF	0.8087	0.5756	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:12	LESPAHQKF	0.8051	0.7086	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:13	HQKFEELVY	0.7786	0.6701	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:11	HQKFEELVY	0.7642	0.9001	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:04	HQKFEELVY	0.7529	0.913	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B08:18	PAHQKFEEL	0.7476	0.8018	8	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:73	HQKFEELVY	0.746	0.9049	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B35:20	HQKFEELVY	0.7305	0.9354	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B57:02	KFEELVYLW	0.7163	0.937	12	21
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:09	QKFEELVYL	0.704	0.6962	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B48:02	LESPAHQKF	0.6966	0.508	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:13	LESPAHQKF	0.6934	0.5227	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:54	LESPAHQKF	0.6802	0.5396	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:08	HQKFEELVY	0.6772	0.8282	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:07	HQKFEELVY	0.6583	0.8253	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:06	HQKFEELVY	0.6575	0.9062	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:11	QKFEELVYL	0.65	0.8732	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:13	KFEELVYLW	0.6167	0.8065	12	21
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:05	HQKFEELVY	0.6153	0.9042	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:30	HQKFEELVY	0.6014	0.7839	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:03	HQKFEELVY	0.5835	0.8937	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B48:02	QKFEELVYL	0.5822	0.9204	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C12:02	HQKFEELVY	0.4176	0.9519	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B48:02	HQKFEELVY	0.3886	0.9117	10	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C06:17	QKFEELVYL	0.324	0.9917	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-C06:02	QKFEELVYL	0.324	0.9917	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:02	LESPAHQKF	0.109	0.738	5	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:54	QKFEELVYL	0.0895	0.7153	11	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B07:09	SPAHQKFEEL	0.9983	0.5448	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B07:22	SPAHQKFEEL	0.9983	0.522	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:24	LLESPAHQKF	0.9975	0.7027	4	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:53	LLESPAHQKF	0.9968	0.5972	4	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:73	HQKFEELVYL	0.9855	0.8343	10	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:30	HQKFEELVYL	0.9788	0.7182	10	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B44:26	LLESPAHQKF	0.9427	0.8087	4	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B44:07	LLESPAHQKF	0.9427	0.8087	4	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B44:13	LLESPAHQKF	0.9427	0.8087	4	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B08:18	SPAHQKFEEL	0.9221	0.7217	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:12	AHQKFEELVY	0.9117	0.8395	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:50	AHQKFEELVY	0.9017	0.8967	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:35	AHQKFEELVY	0.8913	0.7877	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:34	AHQKFEELVY	0.8856	0.7772	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:125	AHQKFEELVY	0.8856	0.7772	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:33	AHQKFEELVY	0.8856	0.7772	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:27	AHQKFEELVY	0.8846	0.8091	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:39	AHQKFEELVY	0.8784	0.756	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:135	AHQKFEELVY	0.8733	0.7856	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:54	AHQKFEELVY	0.8563	0.689	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:53	AHQKFEELVY	0.8539	0.7297	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B48:02	AHQKFEELVY	0.8452	0.915	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B08:12	SPAHQKFEEL	0.8445	0.8132	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:20	AHQKFEELVY	0.8356	0.9223	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-A02:06	HQKFEELVYL	0.8348	0.5064	10	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:24	AHQKFEELVY	0.809	0.7749	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B35:28	AHQKFEELVY	0.8079	0.9303	9	19
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:11	LLESPAHQKF	0.7712	0.6019	4	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B67:01	SPAHQKFEEL	0.6548	0.72	7	17
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:05	LLESPAHQKF	0.64	0.5912	4	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B15:24	HQKFEELVYLW	0.9994	0.8208	10	21
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B38:05	AHQKFEELVYL	0.999	0.9461	9	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B39:11	AHQKFEELVYL	0.9819	0.9072	9	20
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B44:07	QLLESPAHQKF	0.9773	0.7969	3	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B44:26	QLLESPAHQKF	0.9773	0.7969	3	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B44:13	QLLESPAHQKF	0.9773	0.7969	3	14
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	HLA-B18:11	QLLESPAHQKF	0.9183	0.5655	3	14

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Potential FusionNeoAntigen Information of CAMSAP1-KCNT1 in HLA II

CAMSAP1-KCNT1_138758301_138656876.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	DRB5-0101	KQQLLESPAHQKFEE	1	16
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	DRB5-0104	KQQLLESPAHQKFEE	1	16
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	DRB5-0105	KQQLLESPAHQKFEE	1	16
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	DRB5-0106	KQQLLESPAHQKFEE	1	16
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	DRB5-0111	KQQLLESPAHQKFEE	1	16
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	DRB5-0112	KQQLLESPAHQKFEE	1	16
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	DRB5-0113	KQQLLESPAHQKFEE	1	16
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	731	DRB5-0114	KQQLLESPAHQKFEE	1	16

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Fusion breakpoint peptide structures of CAMSAP1-KCNT1

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
2136	ESPAHQKFEELVYL	CAMSAP1	KCNT1	chr9	138758301	chr9	138656876	731

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CAMSAP1-KCNT1

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	2136	ESPAHQKFEELVYL	-7.15543	-7.26883
HLA-B14:02	3BVN	2136	ESPAHQKFEELVYL	-4.77435	-5.80965
HLA-B52:01	3W39	2136	ESPAHQKFEELVYL	-6.80875	-6.92215
HLA-B52:01	3W39	2136	ESPAHQKFEELVYL	-4.20386	-5.23916
HLA-A11:01	4UQ2	2136	ESPAHQKFEELVYL	-7.5194	-8.5547
HLA-A11:01	4UQ2	2136	ESPAHQKFEELVYL	-6.9601	-7.0735
HLA-A24:02	5HGA	2136	ESPAHQKFEELVYL	-7.52403	-7.63743
HLA-A24:02	5HGA	2136	ESPAHQKFEELVYL	-5.82433	-6.85963
HLA-B27:05	6PYJ	2136	ESPAHQKFEELVYL	-3.28285	-4.31815
HLA-B44:05	3DX8	2136	ESPAHQKFEELVYL	-5.91172	-6.94702
HLA-B44:05	3DX8	2136	ESPAHQKFEELVYL	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of CAMSAP1-KCNT1

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	10	19	HQKFEELVY	CATCAAAAGTTCGAGGAGCTCGTCTAC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	10	20	HQKFEELVYL	CATCAAAAGTTCGAGGAGCTCGTCTACCTC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	10	21	HQKFEELVYLW	CATCAAAAGTTCGAGGAGCTCGTCTACCTCTGG
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	11	19	QKFEELVY	CAAAAGTTCGAGGAGCTCGTCTAC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	11	20	QKFEELVYL	CAAAAGTTCGAGGAGCTCGTCTACCTC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	12	20	KFEELVYL	AAGTTCGAGGAGCTCGTCTACCTC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	12	21	KFEELVYLW	AAGTTCGAGGAGCTCGTCTACCTCTGG
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	3	14	QLLESPAHQKF	CAGTTATTGGAAAGTCCAGCTCATCAAAAGTTC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	4	14	LLESPAHQKF	TTATTGGAAAGTCCAGCTCATCAAAAGTTC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	5	14	LESPAHQKF	TTGGAAAGTCCAGCTCATCAAAAGTTC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	7	17	SPAHQKFEEL	AGTCCAGCTCATCAAAAGTTCGAGGAGCTC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	8	17	PAHQKFEEL	CCAGCTCATCAAAAGTTCGAGGAGCTC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	9	17	AHQKFEEL	GCTCATCAAAAGTTCGAGGAGCTC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	9	18	AHQKFEELV	GCTCATCAAAAGTTCGAGGAGCTCGTC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	9	19	AHQKFEELVY	GCTCATCAAAAGTTCGAGGAGCTCGTCTAC
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	9	20	AHQKFEELVYL	GCTCATCAAAAGTTCGAGGAGCTCGTCTACCTC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
CAMSAP1-KCNT1	chr9	138758301	chr9	138656876	1	16	KQQLLESPAHQKFEE	AAACAACAGTTATTGGAAAGTCCAGCTCATCAAAAGTTCGAGGAG

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Information of the samples that have these potential fusion neoantigens of CAMSAP1-KCNT1

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
OV	CAMSAP1-KCNT1	chr9	138758301	ENST00000389532	chr9	138656876	ENST00000263604	TCGA-24-1553

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Potential target of CAR-T therapy development for CAMSAP1-KCNT1

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to CAMSAP1-KCNT1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CAMSAP1-KCNT1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)